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Caroline A Yao, Thomas Imahiyerobo, Jordan Swanson, Allyn Auslander, Diego De Cardenas, Jane C Figueiredo, Meghan McCullough, Melinda Costa, Richard Vanderburg, William P Magee
BACKGROUND: Unilateral cleft lip has a spectrum of disease morphology but severity assessments are difficult given the absence of an accessible, objective assessment tools or reference data. We characterize the spectrum of cleft morphology before and after surgical repair for a large, multi-ethnic population using easily identifiable facial landmarks collected through a novel smart phone-based application. METHODS: Anthropometric measurements and standardized photographs were prospectively collected in Morocco, Bolivia, Vietnam and Madagascar during medical missions in 2015 utilizing an application designed specifically for the study...
September 14, 2017: Plastic and Reconstructive Surgery
Nuno Martinho, Liana C Silva, Helena F Florindo, Steve Brocchini, Teresa Barata, Mire Zloh
Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and structural determination, which can be overcome by judicious use of molecular modelling and molecular simulations. A major difficulty to utilise in silico studies to design dendrimers lies in the laborious generation of their structures. Current modelling tools utilise automated assembly of simpler dendrimers or the inefficient manual assembly of monomer precursors to generate more complicated dendrimer structures...
September 15, 2017: Journal of Computer-aided Molecular Design
Erdem Ayyıldız, Enes Tan, Hakan Keklik, Ahmet A Celebi, Matheus M Pithon
This study aimed to compare the perception of smile esthetics and alterations among dentistry degree students and laypeople to identify differences in the esthetic perception of black spaces between the maxillary central incisors among Turkish laypeople and students in different study years. Photographs altered to include black spaces of various sizes at the midline were evaluated by 208 dentistry students in years 1-5 and 45 Turkish laypeople. Perceptional differences in different photographs were statistically significant...
2017: Journal of Oral Science
Howard Wolinsky
Price, 62, with pure white hair, rimless glasses, and an easy, slightly cherubic smile, comes across like a friendly, family doctor, not the ambitious, politically-minded orthopedic surgeon that he is. He calls the ACA "useless" because of the high deductibles.
August 2017: Managed Care
(no author information available yet)
An evaluation of the influence of teeth and the labial soft tissues on the perceived aesthetics of a smile.
September 8, 2017: British Dental Journal
M A Alagha, X Ju, S Morley, A Ayoub
The aim of this study was to assess the reproducibility of non-verbal facial expressions in unilateral facial paralysis using dynamic four-dimensional (4D) imaging. The Di4D system was used to record five facial expressions of 20 adult patients. The system captured 60 three-dimensional (3D) images per second; each facial expression took 3-4seconds which was recorded in real time. Thus a set of 180 3D facial images was generated for each expression. The procedure was repeated after 30min to assess the reproducibility of the expressions...
September 4, 2017: International Journal of Oral and Maxillofacial Surgery
Yong Woo Ji, Minseo Kim, David Sung Yong Kang, Dan Z Reinstein, Timothy J Archer, Jin Young Choi, Eung Kweon Kim, Hyung Keun Lee, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To determine the effect of lowering femtosecond laser energy on the surface quality of the intrastromal interface during small incision lenticule extraction (SMILE). METHODS: Forty age- and diopter-matched female patients (40 eyes) with moderate myopia received SMILE with different energy levels (100 to 150 nJ) and fixed spot separation (4.5 μm). Five human corneal lenticules from each energy group were evaluated by atomic force microscopy and scanning electron microscopy (SEM)...
September 1, 2017: Journal of Refractive Surgery
Marina Kalashnikova, Christopher Carignan, Denis Burnham
When addressing their young infants, parents systematically modify their speech. Such infant-directed speech (IDS) contains exaggerated vowel formants, which have been proposed to foster language development via articulation of more distinct speech sounds. Here, this assumption is rigorously tested using both acoustic and, for the first time, fine-grained articulatory measures. Mothers were recorded speaking to their infant and to another adult, and measures were taken of their acoustic vowel space, their tongue and lip movements and the length of their vocal tract...
August 2017: Royal Society Open Science
Ahmed A Karim, Britta Lützenkirchen, Eman Khedr, Radwa Khalil
Have you ever noticed that in watch advertisements the time is usually set at 10:10? The reasons and psychological effects of this default time setting are elusive. In Experiment 1, we hypothesized that watches showing a time setting resembling a smiling face (10:10) would enhance emotional valence and intention to buy compared to a neutral time setting (11:30), whereas a time setting resembling a sad face (8:20) would have the opposite effect. Moreover, we investigated a possible interaction effect with the gender of the participants...
2017: Frontiers in Psychology
Ben F M Wijnen, Iris Mosweu, Marian H J M Majoie, Leone Ridsdale, Reina J A de Kinderen, Silvia M A A Evers, Paul McCrone
OBJECTIVE: To investigate the responsiveness of and correlation between the EQ-5D-5L and the QOLIE-31P in patients with epilepsy, and develop a mapping function to predict EQ-5D-5L values based on the QOLIE-31P for use in economic evaluations. METHODS: The dataset was derived from two clinical trials, the ZMILE study in the Netherlands and the SMILE study in the UK. In both studies, patients' quality of life using the EQ-5D-5L and QOLIE-31P was measured at baseline and 12 months follow-up...
September 4, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
Stefano Del Monte, Kelvin I Afrashtehfar, Elham Emami, Samer Abi Nader, Faleh Tamimi
STATEMENT OF PROBLEM: An objective definition of the characteristics that render a smile esthetically acceptable in the eye of laypeople is lacking. PURPOSE: The purpose of this systematic review was to identify, appraise, and synthesize the available evidence on the opinion of laypeople regarding the dentogingival characteristics that render a smile esthetically acceptable. The evidence was collected by surveying with standardized digitally modified smile images...
September 1, 2017: Journal of Prosthetic Dentistry
Yuan-Yuan Han, Xiao-Dong Wang, Li Liu, Hong-Mei Guo, Wei Cong, Wen-Wen Yan, Jun-Ni Huang, Peng Xiao, Chu-Hua Li
Although L-type voltage-dependent calcium channels (VDCCs) have been reported to display different even contrary actions on cognitive functions and long-term potentiation (LTP) formation, there is little information regarding the role of L-type VDCCs in behavioral LTP, a learning-induced LTP model, in the intact brain of freely behaving animals. Here we investigated the effects of verapamil, a non-selective blocker of L-type VDCCs, on behavioral LTP and cognitive functions. Population spikes (PS) were recorded by using electrophysiological methods to examine the role of verapamil in behavioral LTP in the hippocampal dentate gyrus (DG) region...
September 1, 2017: Neurobiology of Learning and Memory
Krystyna Adams, Jeremy Snyder, Valorie A Crooks, Nicole S Berry
Los Algodones, Mexico is characteristic of other medical border towns whose proximity to the Mexico-United States border enables American and Canadian patients to take advantage of economic asymmetries on either side of the border to access desired health care. Los Algodones is unique, however, in its focus on the provision of dental care and claims by local residents that it has the highest concentration of dentists per capita in the world. In this paper, we present an analysis of interviews with employees working in Los Algodones' dental tourism industry to examine interviewees' participation in practices related to reputational management of the industry site...
August 24, 2017: Social Science & Medicine
Marzio Gerbella, Fausto Caruana, Giacomo Rizzolatti
The aim of the present review is to discuss the localization of circuits that allow recognition of emotional facial expressions in blindsight patients. Because recognition of facial expressions is function of different centers, and their localization is not always clear, we decided to discuss here three emotional facial expression - smiling, disgust, and fear - whose anatomical localization in the pregenual sector of the anterior cingulate cortex (pACC), anterior insula (AI), and amygdala, respectively, is well established...
August 29, 2017: Neuropsychologia
Monique Solon Mello, Renata P M V L Milioni, Gustavo O Dos Santos, Leandro Martins, Raphael V Monte Alto
Several factors, including anomalies of shape, color, or size, or positioning of the teeth, may interfere with smile esthetics. A 26-year-old woman was dissatisfied with the esthetics of her maxillary lateral incisors, which had defective composite resin restorations with alterations of color and shape. The aim of this article is to present a step-by-step description of the technique used to fabricate esthetic restorations for the conoid maxillary lateral incisors with a minimum of dental preparation. The successful outcome demonstrates the importance of correct planning for successful restorations...
September 2017: General Dentistry
Jennifer Chmura, Joshua Rosing, Steven Collazos, Shikha J Goodwin
Brain-computer interfaces (BCIs) are an emerging technology that are capable of turning brain electrical activity into commands for an external device. Motor imagery (MI)-when a person imagines a motion without executing it-is widely employed in BCI devices for motor control because of the endogenous origin of its neural control mechanisms, and the similarity in brain activation to actual movements. Challenges with translating a MI-BCI into a practical device used outside laboratories include the extensive training required, often due to poor user engagement and visual feedback response delays; poor user flexibility/freedom to time the execution/inhibition of their movements, and to control the movement type (right arm vs...
2017: Frontiers in Neurorobotics
Chen Chen, Hongmin He
Extranodal NK/T cell lymphoma (ENKL) is a rare entity, associated with an aggressive clinical behavior and poor prognosis. The optimal treatment strategies, particularly for relapsed patients, have not been clearly determined. A 40-year-old female ENKL patient with orbital involvement as the first presentation was initially suspected to have an orbital pseudotumor. When the patient developed disease progression following treatment with methylprednisolone, biopsy of the orbital mass was performed. Histopathological examination of the biopsy specimen was consistent with the diagnosis of ENKL (Ann Arbor stage IE)...
October 2017: Molecular and Clinical Oncology
Donny M Camera, Jatin G Burniston, Mark A Pogson, William J Smiles, John A Hawley
It is generally accepted that muscle adaptation to resistance exercise (REX) training is underpinned by contraction-induced, increased rates of protein synthesis and dietary protein availability. By using dynamic proteome profiling (DPP), we investigated the contribution of both synthesis and breakdown to changes in abundance on a protein-by-protein basis in human skeletal muscle. Age-matched, overweight males consumed 9 d of a high-fat, low-carbohydrate diet during which time they either undertook 3 sessions of REX or performed no exercise...
August 30, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Shao-Feng Wang, Xiao-Ping Cao, Yang Li
We develop a highly efficient aryl migration from an aryl ether to ester ether via retro-Smiles rearrangement by visible-light photoredox catalysis at ambient temperature. Transition metals, stoichiometric oxidant and base are avoided during the transformation. Inspired by the high efficiency of this transformation and the fundamental importance of C-O bond cleavage, a novel approach to C-O cleavage of biaryl ether for two phenolic compounds is demonstrated by a one-pot, two-step gram-scale reaction under mild conditions...
August 28, 2017: Angewandte Chemie
J Burazovitch, D Naguzeswski, T Beuste, M Guillard
OBJECTIVE: To determine whether the visual outcomes of the refractive surgery technique, small incision lenticule extraction (SMILE), are stable, effective, and predictable for high myopia over a four-year period. RESEARCH DESIGN: This is a retrospective study. The data were collected between March 2012 and July 2016. PARTICIPANTS: Two hundred and forty-eight patients participated in the study; that is, 496 eyes: 140 eyes of 70 patients (52 women/18 men) were classified in the highly myopic group (refraction measured in spherical equivalent [RMSE]>-6D), and 356 eyes of 178 patients (98 women/80 men) in the control group (RMSE≤-6D)...
September 2017: Journal Français D'ophtalmologie
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