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https://www.readbyqxmd.com/read/29334434/the-case-for-stabilized-stannous-fluoride-dentifrice-an-advanced-formulation-designed-for-patient-preference
#1
Tao He, Svetlana Farrell
Oral diseases, particularly caries and gingivitis, continue to be widespread. Incorporating a stabilized stannous fluoride dentifrice into patients' daily oral hygiene routine is a convenient, cost effective approach to improve and protect their oral health and the appearance of their smile. Unlike other common fluorides that only provide anti-caries benefits (e.g., sodium fluoride and sodium monofluorophosphate), stabilized stannous fluoride formulations have demonstrated broader and significantly greater protection, also reducing plaque, gingivitis, erosion, sensitivity, and halitosis...
December 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29332601/quantitative-structure-activity-relationship-study-of-betulinic-acid-derivatives-against-hiv-using-smiles-based-descriptors
#2
Apilak Worachartcheewan, Alla P Toropova, Andrey A Toropov, Suphakit Siriwong, Jatupat Prapojanasomboon, Virapong Prachayasittikul, Chanin Nanatasenamat
BACKGROUND: Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS) that imposes a global health burden. Therefore, HIV therapeutic agents have been discovery and development. OBJECTIVE: To construct quantitative-structure activity relationship (QSAR) models of betulinic acid derivatives with anti-HIV activity using simplified molecular-input line-entry system (SMILES)-based descriptors Methods: A data set of 107 betulinic acid derivatives and their anti-HIV activity was used to develop QSAR models...
January 11, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29329266/relative-validity-of-a-24-h-recall-in-assessing-intake-of-key-nutrients-in-a-cohort-of-australian-toddlers
#3
Elizabeth Beaton, Janine Wright, Gemma Devenish, Loc Do, Jane Scott
There is limited information concerning the dietary intake of toddlers in Australia. Consequently, there is a need for studies investigating toddler intake that use dietary assessment measures that are valid and place a low participant burden on caregivers. The aim of this study was to determine the relative validity of a single 24-h dietary recall (24HR) in measuring the intake of five nutrients in a cohort of Australian toddlers compared to a combined 24HR and 2-day estimated food record (2DFR). A single 24HR and a 2DFR were collected from a cohort of Australian toddlers (n = 699) at approximately 12 months of age as part of the Study of Mothers' and Infants' Life Events affecting oral health (SMILE) project...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29325861/crystallographic-and-morphological-analysis-of-sandblasted-highly-translucent-dental-zirconia
#4
Masanao Inokoshi, Haruki Shimizu, Kosuke Nozaki, Tomohiro Takagaki, Kumiko Yoshihara, Noriyuki Nagaoka, Fei Zhang, Jozef Vleugels, Bart Van Meerbeek, Shunsuke Minakuchi
OBJECTIVE: To assess the influence of alumina sandblasting on four highly translucent dental zirconia grades. METHODS: Fully sintered zirconia disk-shaped specimens (15-mm diameter; 0.5-mm thickness) of four highly translucent yttria partially stabilized zirconia (Y-PSZ) grades (KATANA HT, KATANA STML, KATANA UTML, Kuraray Noritake; Zpex Smile, Tosoh) were sandblasted with 50-μm alumina (Al2O3) sand (Kulzer) or left 'as-sintered' (control) (n=5). For each zirconia grade, the translucency was measured using a colorimeter...
January 8, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29322603/the-nerve-supply-of-zygomaticus-major-variability-and-distinguishing-zygomatic-from-buccal-facial-nerve-branches
#5
A Kehrer, S Engelmann, R Bauer, C Taeger, S Grechenig, M Kehrer, L Prantl, E Tamm, Rlaw Bleys, V Mandlik
INTRODUCTION The zygomaticus major (ZM) is important for the human smile. There are conflicting data about whether the zygomatic or buccal branches of the facial nerve are responsible for its motor innervation. The literature provides no precise distinction of the transition zone between these two branch systems. In this study, a definition to distinguish the facial nerve branches at the level of the body of the zygoma is proposed. In the light of this definition, we conducted an anatomical study to determine how the source of innervation of the ZM was distributed...
January 11, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29319225/de-novo-design-of-bioactive-small-molecules-by-artificial-intelligence
#6
Daniel Merk, Lukas Friedrich, Francesca Grisoni, Gisbert Schneider
Generative artificial intelligence offers a fresh view on molecular design. We present the first-time prospective application of a deep learning model for designing new druglike compounds with desired activities. For this purpose, we trained a recurrent neural network to capture the constitution of a large set of known bioactive compounds represented as SMILES strings. By transfer learning, this general model was fine-tuned on recognizing retinoid X and peroxisome proliferator-activated receptor agonists. We synthesized five top-ranking compounds designed by the generative model...
January 10, 2018: Molecular Informatics
https://www.readbyqxmd.com/read/29318281/she-smiled-as-she-walked-away
#7
Kathleen C Gallagher
No abstract text is available yet for this article.
January 9, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29315436/energy-setting-and-visual-outcomes-in-smile-a-retrospective-cohort-study
#8
Liuyang Li, Julie M Schallhorn, Jiaonan Ma, Tong Cui, Yan Wang
PURPOSE: To assess the independent effect of energy setting on postoperative uncorrected distance visual acuity (UDVA) in small incision lenticule extraction (SMILE) and further investigate an optimal energy setting for the 4.5-μm spot-track-distance, which is in wide clinical use. METHODS: A total of 1,130 eyes were included in a retrospective cohort study from Tianjin Eye Hospital, Tianjin Medical University from April 2015 to July 2016. Energy settings and baseline characteristics were recorded and 3-month UDVA was tested by a nurse blinded to the energy settings used...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29303856/maxillary-sagittal-position-in-relation-to-the-forehead-a-target-for-orthognathic-surgery
#9
Cory M Resnick, Carly E Calabrese, Anthea S Resnick
The relationship of the maxillary incisor to forehead position and angulation may be a predictor for the esthetic antero-posterior maxillary position in orthognathic surgery, but this has not been fully explored in the existing literature. Additionally, this analysis requires a lateral smiling photograph, which is not typically included in orthodontic/orthognathic records. This is a bidirectional study of Caucasian orthodontic patients with malocclusions correctable with nonsurgical and nonextraction treatment...
January 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29301406/do-general-practitioners-record-alcohol-abuse-in-the-electronic-medical-records-a-comparison-of-survey-and-medical-record-data
#10
L Abidi, A Oenema, Marjan van den Akker, D van de Mheen
OBJECTIVE: Primary care professionals are encouraged to screen patients for alcohol abuse. However, patients with alcohol abuse are often underdiagnosed as well as under-registered in medical records in general practices. This study aims to report on the registration rates of alcohol abuse diagnoses in general practices in comparison to patients' self-reported rates of alcohol use disorder. RESEARCH DESIGN AND METHODS: Data of a total number of 2349 patients were analysed from the SMILE study, a large prospective cohort study conducted in The Netherlands...
January 4, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29301376/sistematx-an-online-web-based-cheminformatics-tool-for-data-management-of-secondary-metabolites
#11
Marcus Tullius Scotti, Chonny Herrera-Acevedo, Tiago Branquinho Oliveira, Renan Paiva Oliveira Costa, Silas Yudi Konno de Oliveira Santos, Ricardo Pereira Rodrigues, Luciana Scotti, Fernando Batista Da-Costa
The traditional work of a natural products researcher consists in large part of time-consuming experimental work, collecting biota to prepare and analyze extracts and to identify innovative metabolites. However, along this long scientific path, much information is lost or restricted to a specific niche. The large amounts of data already produced and the science of metabolomics reveal new questions: Are these compounds known or new? How fast can this information be obtained? To answer these and other relevant questions, an appropriate procedure to correctly store information on the data retrieved from the discovered metabolites is necessary...
January 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29288546/the-impact-of-dental-caries-and-its-treatment-by-conventional-or-biological-approaches-on-the-oral-health-related-quality-of-life-of-children-and-carers
#12
Alaa BaniHani, Chris Deery, Jack Toumba, Theresa Munyombwe, Monty Duggal
BACKGROUND: The effect of untreated dental caries and the approaches taken to its treatment have not been extensively elucidated in children. AIM: To investigate the impact of untreated dental caries on children aged 4-9 years and whether its treatment with either a conventional or a biological approach influenced the oral health-related quality of life (OHRQoL) of the children and their carers. DESIGN: Children (n = 110) and their carers attending two specialist centres for treatment of carious primary teeth completed the Early Childhood Oral Health Impact Scale and the Self-reported Scale of Oral Health Outcomes for 5-year-old Children at baseline prior to dental treatment and at 3-6 months following completion of dental care...
December 30, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29287659/effect-of-nonextraction-and-extraction-orthodontic-treatments-on-smile-esthetics-for-different-malocclusions
#13
Hsin-Chung Cheng, Yi-Chun Wang
INTRODUCTION: Smile esthetics is a critical factor for evaluating orthodontic treatment outcomes. In this study, we evaluated the differences in esthetic perceptions and smile variables between extraction and nonextraction treatments for different malocclusions. METHODS: Ninety participants were divided into 3 groups according to their pretreatment overjet (group I, 0-4 mm; group II, >4 mm; group III, <0 mm), with 15 extraction participants and 15 nonextraction participants in each group...
January 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29287638/surgery-first-using-skeletal-anchorage-with-tandem-mechanics-for-mandibular-molar-distalization
#14
Carlos Alberto Estevanell Tavares, Miguel Angelo R Sheffer, Susiane Allgayer
This case report describes the orthodontic retreatment a patient with a skeletal Class III malocclusion. The clinical examination showed a concave profile caused by a retruded maxilla and a prognathic mandible, an occlusal cant, and absence of all first premolars. A surgery-first approach was combined with skeletal anchorage implants in the maxillary arch and tandem mechanics. The esthetic facial profile, pleasant smile, appropriate occlusion, and overall good treatment outcomes remained stable 5 years after active orthodontic treatment...
January 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29287637/long-term-changes-of-the-anterior-palatal-alveolar-bone-after-treatment-with-bialveolar-protrusion-evaluated-with-computed-tomography
#15
Seong-Min Bae, Ho-Jin Kim, Hee-Moon Kyung
This case report describes the treatment of a 31-year-old woman with a convex profile, protrusive maxilla, retrusive mandible, and gummy smile. Four premolars were extracted, and micro-implant anchorage was used to retract the anterior teeth. Lip protrusion and the gummy smile were improved, but the computed tomography images showed dehiscence on the palatal alveolar bone of the maxillary incisors. Approximately 10 years after treatment, significant alveolar bone apposition was seen on the palatal surface of the maxillary anterior teeth...
January 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29285855/esthetics-and-smile-related-characteristics-assessed-by-laypersons
#16
Cui Wang, Wen-Jie Hu, Ling-Zhi Liang, Yan-Ling Zhang, Kwok-Hung Chung
PURPOSE: This study aimed to identify the characteristics of full-smile images assessed by laypersons using visual analog scale measurement. MATERIALS AND METHODS: A total of 176 young Chinese subjects (88 males and 88 females; 20-35 years of age) with healthy dentogingival tissue were recruited to have their dynamic smiles captured using digital technology. A full-smile frame image of each subject was selected and evaluated by 22 laypersons (11 males and 11 females; 20-35 years of age) using visual analog scale measurement...
December 29, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29285853/development-and-validation-of-a-new-condition-specific-instrument-for-evaluation-of-smile-esthetics-related-quality-of-life
#17
Ema Saltovic, Vlatka Lajnert, Sabina Saltovic, Daniela Kovacevic Pavicic, Andrej Pavlic, Stjepan Spalj
OBJECTIVE: Orofacial esthetics raises psychosocial issues. The purpose was to create and validate new short instrument for psychosocial impacts of altered smile esthetics. MATERIALS AND METHODS: A team of an orthodontist, two prosthodontists, psychologist, and a dental student generated items that could draw up specific hypothetical psychosocial dimensions (69 items initially, 39 in final analysis). The sample consisted of 261 Caucasian subjects attending local high schools and university (26% male) aged 14 to 28 years that have self-administrated the designed questionnaire...
December 29, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29283117/refractive-lenticule-extraction-small-incision-lenticule-extraction-a-new-refractive-surgery-paradigm
#18
REVIEW
Sri Ganesh, Sheetal Brar, Raghavender Reddy Arra
Small incision lenticule extraction (SMILE), a variant of refractive lenticule extraction technology is becoming increasingly popular, as a flapless and minimally invasive form of laser vision correction (LVC) for the treatment of myopia and myopic astigmatism. This review aims at summarizing the principles, surgical technique, and clinical outcomes in terms of visual and refractive results, safety, efficacy, postoperative dry eye, aberrations, and biomechanics of SMILE and its comparison with other conventional techniques of LVC, such as laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK)...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29281931/mutagenicity-anticancer-activity-and-blood-brain-barrier-similarity-and-dissimilarity-of-molecular-alerts
#19
Andrey A Toropov, Alla P Toropova, Emilio Benfenati, Mario Salmona
The aim of the present work is an attempt to define computable measure of similarity between different endpoints. The similarity of structural alerts of different biochemical endpoints can be used to solve tasks of medicinal chemistry. Optimal descriptors are a tool to build up models for different endpoints. The optimal descriptor is calculated with simplified molecular input-line entry system (SMILES). A group of elements (single symbol or pair of symbols) can represent any SMILES. Each element of SMILES can be represented by so-called correlation weight i...
December 27, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29279765/investigation-of-the-cytotoxicity-of-thermoplastic-denture-base-resins
#20
Jung-Hwan Lee, Soo-Kyung Jun, Si-Chul Kim, Chikahiro Okubo, Hae-Hyoung Lee
PURPOSE: The purpose of this study was to investigate the in vitro cytotoxicity of thermoplastic denture base resins and to identify the possible adverse effects of these resins on oral keratinocytes in response to hot water/food intake. MATERIALS AND METHODS: Six dental thermoplastic resin materials were evaluated: three polyamide materials (Smile tone, ST; Valplast, VP; and Luciton FRS, LF), two acrylic materials (Acrytone, AT; and Acryshot, AS), and one polypropylene resin material (Unigum, UG)...
December 2017: Journal of Advanced Prosthodontics
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