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https://www.readbyqxmd.com/read/28092781/social-consequences-of-subclinical-negative-symptoms-an-emg-study-of-facial-expressions-within-a-social-interaction
#1
Marcel Riehle, Tania M Lincoln
BACKGROUND AND OBJECTIVES: The negative symptoms of schizophrenia are related to lower social functioning even in non-clinical samples, but little is known about the distinct social consequences of motivational and expressive negative symptoms. In this study we focused on expressive negative symptoms and examined how these symptoms and varying degrees of pro-social facial expressiveness (smiling and mimicry of smiling) relate to the social evaluations by face-to-face interaction partners and to social support...
January 10, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28092692/smile-seq-identifies-binding-motifs-of-single-and-dimeric-transcription-factors
#2
Alina Isakova, Romain Groux, Michael Imbeault, Pernille Rainer, Daniel Alpern, Riccardo Dainese, Giovanna Ambrosini, Didier Trono, Philipp Bucher, Bart Deplancke
Resolving the DNA-binding specificities of transcription factors (TFs) is of critical value for understanding gene regulation. Here, we present a novel, semiautomated protein-DNA interaction characterization technology, selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq). SMiLE-seq is neither limited by DNA bait length nor biased toward strong affinity binders; it probes the DNA-binding properties of TFs over a wide affinity range in a fast and cost-effective fashion. We validated SMiLE-seq by analyzing 58 full-length human, mouse, and Drosophila TFs from distinct structural classes...
January 16, 2017: Nature Methods
https://www.readbyqxmd.com/read/28087576/circulating-modified-metabolites-and-a-risk-of-esrd-in-patients-with-type-1-diabetes-and-chronic-kidney-disease
#3
Monika A Niewczas, Anna V Mathew, Stephanie Croall, Jaeman Byun, Melissa Major, Venkatta S Sabisetti, Adam Smiles, Joseph V Bonventre, Subramaniam Pennathur, Andrzej S Krolewski
OBJECTIVE: Patients with type 1 diabetes (T1D) with impaired renal function are at increased risk for end-stage renal disease (ESRD). Although the rate of progression varies, determinants and mechanisms of this variation are unknown. RESEARCH DESIGN AND METHODS: We examined serum metabolomic profiles associated with variation in renal function decline in participants with T1D (the Joslin Kidney Study prospective cohort). One hundred fifty-eight patients with proteinuria and chronic kidney disease stage 3 were followed for a median of 11 years to determine estimated glomerular filtration rate slopes from serial measurements of serum creatinine and to ascertain time to onset of ESRD...
January 13, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28087422/nano-qsar-in-cell-biology-model-of-cell-viability-as-a-mathematical-function-of-available-eclectic-data
#4
Alla P Toropova, Andrey A Toropov
The prediction of biochemical endpoints is an important task of the modern medicinal chemistry, cell biology, and nanotechnology. Simplified molecular input-line entry system (SMILES) is a tool for representation of the molecular structure. In particular, SMILES can be used to build up the quantitative structure - property / activity relationships (QSPRs/QSARs). The QSPR/QSAR is a tool to predict an endpoint for a new substance, which has not been examined in experiment. Quasi-SMILES are representation of eclectic data related to an endpoint...
January 10, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28079793/oral-health-related-quality-of-life-in-pediatric-patients-under-general-anesthesia-a-prospective-study
#5
Lanlan Li, Hongwei Wang, Xueping Han
Our goal was to evaluate how dental treatments under general anesthesia (GA) affect the quality of life by a prospective pair-matched design. Pediatric patients, who had received dental treatments under GA, were enrolled and were asked to complete the Early Childhood Oral Health Impact Scale (ECOHIS) before the treatment and 1 month after the treatment. To shield the observed impacts, a pair-matched control group was performed. Patients in the control group were also required to complete the ECOHIS at these different points in time...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28068443/possible-risk-factors-and-clinical-effects-of-opaque-bubble-layer-in-small-incision-lenticule-extraction-smile
#6
Gisung Son, Junghyun Lee, Cheolwon Jang, Ki Yong Choi, Beom Jin Cho, Tae Hyung Lim
PURPOSE: To report the development of an opaque bubble layer (OBL) during small incision lenticule extraction (SMILE) and analyze its potential risk factors and the clinical outcome. METHODS: A retrospective review of medical records was performed. The patients were divided into two groups in terms of OBL area following a posterior lenticule cut: OBL less than 5% of cornea and OBL greater than 5% of cornea. Preoperative parameters and clinical outcomes were compared...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28068441/changes-in-astigmatism-densitometry-and-aberrations-after-smile-for-low-to-high-myopic-astigmatism-a-12-month-prospective-study
#7
Iben Bach Pedersen, Anders Ivarsen, Jesper Hjortdal
PURPOSE: To evaluate 12-month changes in refraction, visual outcome, corneal densitometry, and postoperative aberrations after small incision lenticule extraction (SMILE) for myopic astigmatism. METHODS: This 12-month prospective clinical trial comprised 101 eyes (101 patients) treated with SMILE for myopic astigmatism with cylinder of 0.75 to 4.00 diopters (D). The preoperative, 1-week, and 1-, 3-, 6-, 9-, and 12-month examinations included measurement of manifest refraction, uncorrected distance visual acuity (UDVA), and corrected (CDVA) distance visual acuity...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28060071/corneal-lenticule-allotransplantation-after-femtosecond-laser-small-incision-lenticule-extraction-in-rabbits
#8
Jing Zhao, Yang Shen, Mi Tian, Ling Sun, Yu Zhao, Xiaoyu Zhang, Xingtao Zhou
PURPOSE: To investigate the feasibility of allotransplanting extracted lenticules after femtosecond laser-assisted small incision lenticule extraction (SMILE) in rabbits and the subsequent healing process. METHODS: Fourteen New Zealand white rabbits were divided evenly into 2 groups. The rabbits in group A received SMILE procedures with a -6.00 D correction. The lenticules from group A were immediately inserted into a femtosecond laser-created corneal stromal pocket in group B...
February 2017: Cornea
https://www.readbyqxmd.com/read/28059619/comparison-of-iatrogenic-pain-between-rotavirus-vaccination-before-and-after-vaccine-injection-in-2-month-old-infants
#9
Hui-Chu Yin, Whei-Mei Shih, Hsiu-Lan Lee, Huei-Jing Yang, Yu-Li Chen, Shao-Wen Cheng, Chun-Yuh Yang, Ya-Wen Chiu, Yi-Hao Weng
Oral rotavirus vaccine (RV) administration in conjunction with other injectable vaccines has been used worldwide. However, whether the sequence of RV administration is associated with the reduction of injection-induced pain remains unclear. In this randomized controlled trial, we enrolled 6-12-wk-old healthy infants. The pain response of the infants was scored on the basis of their crying, irritability, facial expression, gagging and distress. A multivariate logistic regression model was used to compare the pain response after adjustment for possible confounders...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28059576/twitter-analysis-of-the-orthodontic-patient-experience-with-braces-vs-invisalign
#10
Daniel Noll, Brendan Mahon, Bhavna Shroff, Caroline Carrico, Steven J Lindauer
OBJECTIVE: To examine the orthodontic patient experience having braces compared with Invisalign by means of a large-scale Twitter sentiment analysis. MATERIALS AND METHODS: A custom data collection program was created that collected tweets containing the words "braces" or "Invisalign" for a period of 5 months. A hierarchal Naïve Bayes sentiment analysis classifier was developed to sort the tweets into five categories: positive, negative, neutral, advertisement, or not applicable...
January 6, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28058160/long-term-results-of-small-incision-lenticule-extraction-in-high-myopia
#11
Yusuf Yıldırım, Cengiz Alagöz, Abdülvahit Demir, Onur Ölçücü, Mehmet Özveren, Alper Ağca, Engin Bilge Özgürhan, Ahmet Demirok
OBJECTIVES: To evaluate two-year results of small-incision lenticule extraction (SMILE) for correction of high myopia. MATERIALS AND METHODS: Forty-five eyes of 35 patients with mean spherical equivalent (SE) of -7.10±0.95 D who underwent routine SMILE by a single surgeon and were followed for at least 2 years were analyzed by retrospective chart review. SMILE was performed with a Visumax femtosecond laser (Carl Zeiss Meditec, Jena, Germany). Follow-up intervals were at 1, 6, 12, and 24 months after surgery...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28056566/large-scale-classification-of-p-glycoprotein-inhibitors-using-smiles-based-descriptors
#12
V Prachayasittikul, A Worachartcheewan, A P Toropova, A A Toropov, N Schaduangrat, V Prachayasittikul, C Nantasenamat
P-glycoprotein (Pgp) inhibition has been considered as an effective strategy towards combating multidrug-resistant cancers. Owing to the substrate promiscuity of Pgp, the classification of its interacting ligands is not an easy task and is an ongoing issue of debate. Chemical structures can be represented by the simplified molecular input line entry system (SMILES) in the form of linear string of symbols. In this study, the SMILES notations of 2254 Pgp inhibitors including 1341 active, and 913 inactive compounds were used for the construction of a SMILE-based classification model using CORrelation And Logic (CORAL) software...
January 6, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28054792/minimally-invasive-dentistry-a-conservative-approach-to-smile-makeover
#13
Jeffrey M Rosenberg
The concept of minimally invasive dentistry is based on preserving tooth structure, especially enamel. A conservative method to treat discolored teeth that have diastemas is a freehand additive technique using composite resin. While selecting the correct shade of resin can be challenging, newer composite resin formulations are being developed with optical properties that enable the material to more effectively blend into the dentition. This case report describes the use of conservative approaches and materials to treat discolored, unevenly spaced teeth and restore harmony and balance to a patient's smile...
January 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28045724/out-of-hospital-perimortem-cesarean-delivery-performed-in-a-woman-at-32-weeks-of-gestation-a-case-report
#14
Harald Lenz, Liv Berit Stenseth, Nina Meidell, Hans Julius Heimdal
A 34-year-old pregnant woman experienced cardiac arrest at home. Out-of-hospital perimortem cesarean delivery was performed 27 minutes after the collapse. Both mother and child were resuscitated and had return of spontaneous circulation before they were transported to a university hospital. The mother underwent hysterectomy and developed disseminated intravascular coagulation. Despite intensive treatment, she died 8.5 hours after arrival. The infant was extubated the next day, and her subsequent hospital course was uneventful...
December 30, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/28032172/effects-of-the-rhinoplasty-maneuvers-on-upper-lip-position-and-incisor-show
#15
Hongyang Pi, David E Kurlander, Bahman Guyuron
BACKGROUND: Smiling involves dynamic movements that include nasal tip descent and upper lip ascent. The effect of rhinoplasty on upper lip position is poorly described. METHODS: One hundred charts were reviewed in reverse chronologic order. Inclusion criteria were receiving one of the rhinoplasty maneuvers of interest, at least 6 months of follow-up, and pre- and postoperative photographs by a professional medical photographer with matching maximum smile extent and size...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28028418/buccal-corridors-a-fact-or-a-myth-in-the-eyes-of-laymen
#16
Omnia A Elhiny, Asmaa Y Harhash
AIM: This study aimed to investigate laymen knowledge of the existence of the buccal corridor and whether it was an important factor for them in judging smile attractiveness and the effect of introducing the knowledge to them on their further judgment. MATERIALS AND METHODS: Nine subjects were randomly selected with variable buccal corridor percentages. They were coached to smile in a posed fashion and full face smile photographs were taken from a standardised distance...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28024491/-children-s-nk-t-cell-lymphoma-associated-hemophagocytic-syndrome-clinical-analysis-of-6-cases
#17
Yong-Zhi Zheng, Hao Zheng, Jian Li, Shao-Hua LE, Xue-Ling Hua, Zai-Sheng Chen, Ling Zheng, Mei Li, Yi-Qiao Chen, Qin-Li Gao, Jing-Hui Yang, Jian-Da Hu
OBJECTIVE: To study the clinical features, treatment and prognosis of patients with NK/T cell lymphoma-associated hemophagocytic syndrome(NK/T-LAHPS). METHODS: Retrospective analysis was used to explore the clinical data of 6 children with NK/T-LAHPS who were admitted in Department of Pediatric Hematology of Fujian Medical University Union Hospital from July 2012 to June 2016. The 6 patients included 4 boys and 2 girls, with a median age of 4 years(range 1.75 to 11)...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28011182/dynamic-facial-asymmetry-in-patients-with-repaired-cleft-lip-using-4d-imaging-video-stereophotogrammetry
#18
Rami R Hallac, Jennifer Feng, Alex A Kane, James R Seaward
BACKGROUND: Unilateral cleft lip is a profoundly asymmetrical condition affecting all hard and soft tissue layers from the nose to the upper lip. Although the asymmetry is minimized through cleft lip repair, a degree of asymmetry inevitably persists. Studies investigating asymmetry in patients with cleft lip have used facial measurements, and static 2D and 3D photography. The nose/lip/mouth area, however, is rarely static in our day to day social interactions. METHODS: Non-syndromic patients with cleft lip and palate, and a control group without orofacial clefts underwent 50 frames per second 4D imaging while generating facial expressions including smiling and pouting...
January 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28009597/a-review-of-treatment-for-breast-cancer-related-lymphedema-paradigms-for-clinical-practice
#19
Timothy D Smile, Rahul Tendulkar, Graham Schwarz, Douglas Arthur, Stephen Grobmyer, Stephanie Valente, Frank Vicini, Chirag Shah
OBJECTIVES: Breast cancer-related lymphedema (BCRL) represents a major complication of breast cancer treatment, impacting the quality of life for breast cancer survivors that develop it. The purpose of this review is to evaluate the literature surrounding BCRL treatment modalities to guide clinicians regarding risk-stratified treatment options. METHODS: A review of studies over a 10-year period (January 2006 to February 2016) was performed. Noninvasive strategies evaluated included compression therapy, manual lymphatic drainage, and complex decongestive therapy (CDT)...
December 22, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28005772/correction-of-residual-static-and-dynamic-labial-deviations-in-a-paralyzed-face-after-free-gracilis-muscle-transplantation
#20
Ricardo Horta, Inês Correia-Sá, Ricardo Nascimento, Alvaro Silva, José Amarante
Free muscle flap transfer is currently the procedure of choice for longstanding facial paralysis to restore symmetry both at rest and when smiling. However, movements obtained are generally localized, unidirectional, and philtrum centralization and lower lip movement is not proportionally achieved. The stability of free flap insertion at the lips also interferes with the results, as gradual disinsertion and shifting of the nasolabial fold can be caused by repetitive movements. Asymmetry of smile can also be caused by lip depressor inactivity due to marginal mandibular paralysis, and both dynamic and static procedures are often required after dynamic reanimation...
November 2016: Journal of Craniofacial Surgery
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