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https://www.readbyqxmd.com/read/28737911/platform-for-unified-molecular-analysis-puma
#1
Mariana González-Medina, Jose Luis Medina-Franco
We introduce a free platform for chemoinformatic-based diversity analysis and visualization of chemical space of user supplied data sets. Platform for Unified Molecular Analysis (PUMA) integrates metrics used to characterize compound databases including visualization of chemical space, scaffold content, and analysis of chemical diversity. The user's input is a file with SMILES, database names, and compound IDs. PUMA computes molecular properties of pharmaceutical relevance, Murcko scaffolds, and diversity analysis...
July 24, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28733805/onabotulinumtoxina-botox-in-the-treatment-of-crow-s-feet-lines-in-japanese-subjects
#2
Kiyonori Harii, Makoto Kawashima, Nobutaka Furuyama, Xiaofang Lei, René Hopfinger, Elisabeth Lee
BACKGROUND: This study evaluated the safety and efficacy of onabotulinumtoxinA in Japanese subjects with crow's feet lines (CFL). METHODS: This phase 3, multicenter, double-blind, randomized study included 2 treatment periods: 6-month placebo-controlled period followed by a 7-month open-label period. In period 1, subjects with moderate to severe CFL received onabotulinumtoxinA 24 U (n = 104) or 12 U (n = 99), or placebo (n = 97). In period 2, placebo subjects switched to onabotulinumtoxinA 24 U or 12 U (double-blind dose)...
July 21, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28733297/behind-the-smile-qualitative-study-of-caregivers-anguish-and-management-responses-while-caring-for-someone-living-with-heart-failure
#3
Jennifer Wingham, Julia Frost, Nicky Britten
BACKGROUND: Caregivers support self-management in heart failure but often experience stress, anxiety and ill health as a result of providing care. AIMS: 1. To identify the factors that contribute to the experience of anguish.2. To understand how caregivers learn to live with what is frequently a challenging and demanding role. METHODS: Individual interviews with caregivers who had been caring for someone with heart failure for a minimum of 6 months...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28732617/vector-analysis-of-astigmatic-changes-after-small-incision-lenticule-extraction-and%C3%A2-wavefront-guided-laser-in-situ-keratomileusis
#4
Mounir A Khalifa, Ahmed M Ghoneim, Mohamed Shafik Shaheen, David P Piñero
PURPOSE: To evaluate and compare the efficacy of the astigmatic correction after wavefront-guided laser in situ keratomileusis (LASIK) and small-incision lenticule extraction (SMILE) and in myopic eyes. DESIGN: Prospective case series. SETTING: Horus Vision Correction Center and Ellite Vision Correction Center, Alexandria, Egypt. METHODS: Myopic eyes with astigmatism up to 4.00 diopters (D) had wavefront-guided LASIK or small-incision lenticule extraction...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28732615/new-parameters-for-evaluating-corneal-biomechanics-and-intraocular-pressure-after-small-incision-lenticule-extraction-by%C3%A2-scheimpflug-based-dynamic-tonometry
#5
Joaquín Fernández, Manuel Rodríguez-Vallejo, Javier Martínez, Ana Tauste, Patrizia Salvestrini, David P Piñero
PURPOSE: To evaluate parameters and dynamic corneal densitometry with a new dynamic Scheimpflug analyzer (Corvis ST) in eyes having small-incision lenticule extraction (SMILE). SETTING: Qvision, Vithas Virgen del Mar Hospital, Almería, Spain. DESIGN: Retrospective case series. METHODS: The study comprised eyes from the same institution having small-incision lenticule extraction surgery. Preoperative and 1-month postoperative measurements were taken...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28732614/incidence-and-management-of-intraoperative-complications-during-small-incision-lenticule-extraction-in-3004-cases
#6
Yan Wang, Jiaonan Ma, Jiamei Zhang, Rui Dou, Hui Zhang, Liuyang Li, Wei Zhao, Pinghui Wei
PURPOSE: To assess the intraoperative complications during small-incision lenticule extraction (SMILE) for myopia and myopic astigmatism correction and evaluate visual outcomes 6 months postoperatively. SETTING: Tianjin Eye Hospital, Tianjin, China. DESIGN: Retrospective case series. METHODS: Patients who had small-incision lenticule extraction surgery were examined 1 day, 7 days, 1 month, 3 months, and 6 months postoperatively...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28729585/glasgow-creates-world-s-biggest-smile
#7
(no author information available yet)
No abstract text is available yet for this article.
July 21, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28727462/tridimensional-reconstruction-of-a-complex-iatrogenic-defect-using-orthodontic-forced-eruption-and-minimally-invasive-bone-grafting
#8
Ernesto A Lee
As the use of dental implants has become more common, so has the frequency of complications and unforeseen outcomes. This article describes the treatment of a complex iatrogenic defect secondary to a failed implant (No. 7) and multiple bone-grafting attempts in the maxillary anterior region. The patient's revealing smile line and high-risk circumstances demanded the use of an interdisciplinary treatment approach with high potential for predictable esthetic results. Forced eruption was performed to restore the alveolar height deficit and develop the compromised hard and soft tissues around teeth Nos...
July 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28725127/assessment-of-the-influence-of-gender-and-skin-color-on-the-preference-of-tooth-shade-in-saudi-population
#9
Nawaf Labban, Hanan Al-Otaibi, Abdulaziz Alayed, Khaled Alshankiti, Mohammad A Al-Enizy
AIM: The aim of the study was to evaluate the influence of gender and skin color on the preference of different teeth shades in general population. MATERIALS AND METHODS: Two standardized frontal smile photographs of male and female subjects were manipulated using photoshop to represent 4 skin colors [(type II, III, IV, and V) (Fitzpatrick scale)]. The teeth shades under each skin color were digitally manipulated to represent one of 6 teeth shades (BL1, BL2, BL3, BL4, B1 and A1)...
July 2017: Saudi Dental Journal
https://www.readbyqxmd.com/read/28717794/the-influence-of-maxillary-incisor-torque-on-the-esthetic-perception-%C3%A2-of-the-smile
#10
Javier Giron de Velasco, Pablo de la Cuadra, Gorka Urizar
PURPOSE: An esthetically pleasing smile is one of our patients' main goals. However, it is not always clear that the esthetic perceptions of patients and clinicians are the same. The purpose of this study was to evaluate and quantify the discrepancies in the esthetic perception of maxillary incisor torque among professionals, and between professionals and the general public. MATERIALS AND METHODS: A photograph of a 30-year-old woman was digitally manipulated to obtain nine smile images and nine full-profile images with various maxillary incisor torques, while maintaining the overjet...
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28716616/relationship-between-spirituality-meaning-in-life-psychological-distress-wish-for-hastened-death-and-their-influence-on-quality-of-life-in-palliative-care-patients
#11
Mathieu Bernard, Florian Strasser, Claudia Gamondi, Giliane Braunschweig, Michaela Forster, Karin Kaspers-Elekes, Silvia Walther Veri, Gian Domenico Borasio
CONTEXT: Spiritual, existential, and psychological issues represent central components of quality of life (QOL) in palliative care. A better understanding of the dynamic underlying these components is essential for the development of interventions tailored to the palliative context. OBJECTIVES: The aims were to explore (i) the relationship between spirituality, meaning in life, wishes for hastened death and psychological distress in palliative patients, and (ii) the extent to which these non-physical determinants influence QOL...
July 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28713600/periodontics-implantology-and-prosthodontics-integrated-the-zenith-driven-rehabilitation
#12
Fausto Frizzera, Mateus Tonetto, Guilherme Cabral, Jamil Awad Shibli, Elcio Marcantonio
A customized treatment plan is important to reach results that will satisfy the patient providing esthetics, function, and long-term stability. This type of oral rehabilitation requires professionals from different dental specialties where communication is a major key point. Digital Smile Design allows the practitioners to plan and discuss the patient's condition to establish the proper treatment plan, which must be driven by the desired zenith position. The ideal gingival position will guide the professionals and determine the need to perform surgical procedures or orthodontic movement before placing the final restorations...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28712192/journey-from-black-to-pink-gums-management-of-melanin-induced-physiological-gingival-hyper-pigmentation
#13
Huma Farid, Muhammad Saad Shinwari, Farhan Raza Khan, Farzin Tanwir
Smile is an expression of happiness, self-confidence, kindness and beauty. Along with teeth and lips, gingiva is also a vital component of smile. Melanin induced gingival hyper pigmentation may appear un-aesthetic especially when it is associated with high smile line, upper anterior labial segment and is uneven in appearance. It affects individuals from all races. Generally, it is believed that melanin induced gingival hyper pigmentation is confined to individuals from dark races. But studies have shown that Iranian, Indian, Italian, Arabian, Greek...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28708898/retreatment-strategies-following-small-incision-lenticule-extraction-smile-in-vivo-tissue-responses
#14
Andri K Riau, Yu-Chi Liu, Chris H L Lim, Nyein C Lwin, Ericia P Teo, Gary H Yam, Donald T Tan, Jodhbir S Mehta
With any refractive correction, including Small Incision Lenticule Extraction (SMILE), there may be a residual refractive error that requires a retreatment. Here, we investigated the tissue responses following various retreatment procedures in a rabbit model of SMILE. All rabbits underwent a -6.00D correction with SMILE. Two weeks later, they underwent -1.00D enhancement by: (i) VisuMax Circle, followed by excimer ablation (S+C); (ii) secondary SMILE anterior to the primary procedure (S+SE); or (iii) surface ablation (S+P), and were examined for 28 days...
2017: PloS One
https://www.readbyqxmd.com/read/28708795/proposal-of-a-video-recording-system-for-the-assessment-of-bell-s-palsy-methodology-and-preliminary-results
#15
Simonetta Monini, Franco Marinozzi, Francesca Atturo, Fabiano Bini, Silvia Marchelletta, Maurizio Barbara
HYPOTHESIS: To propose a new objective video-recording procedure to assess and monitor over time the severity of facial nerve palsy. BACKGROUND: No objective methods for facial palsy (FP) assessment are universally accepted. METHODS: The face of subjects presenting with different degrees of facial nerve deficit, as measured by the House-Brackmann (HB) grading system, was videotaped after positioning, at specific points, 10 gray circular markers made of a retroreflective material...
July 13, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28707557/the-cheek-of-a-cheater-effects-of-posing-the-left-and-right-hemiface-on-the-perception-of-trustworthiness
#16
Matia Okubo, Kenta Ishikawa, Akihiro Kobayashi
Our cognitive mechanisms are designed to detect cheaters in social exchanges. However, cheater detection can be thwarted by a posed smile, which cheaters display with greater emotional intensity than cooperators. The present study investigated the role of hemifacial asymmetries in the perception of trustworthiness using face photographs with left and right cheek poses. Participants (N = 170) observed face photographs of cheaters and cooperators in an economic game. In the photographs, models expressed happiness or anger and turned slightly to the left or right to show their left or right cheeks to the camera...
July 14, 2017: Laterality
https://www.readbyqxmd.com/read/28705589/a-simple-technique-for-the-correction-of-maxillonasal-dysplasia-using-customized-expanded-polytetrafluoroethylene-eptfe-implants
#17
Jiao Wei, Jiawen Luo, Tanja Herrler, Hua Xu, Ning Deng, Qingfeng Li, Chuanchang Dai
BACKGROUND: The treatment of maxillonasal dysplasia in Binder's syndrome using autologous costal bone and cartilage is well established, but postoperative results may be compromised by scarring, unpredictable absorption of transferred autologous tissue, and donor site morbidity. Here, we propose a simple surgical technique to improve maxillonasal dysplasia using an expanded polytetrafluoroethylene (ePTFE) implant. MATERIALS AND METHODS: From February 1999 to May 2014, fifty-eight patients affected by maxillonasal dysplasia with different degrees of flattened nose and midfacial depression underwent surgical correction by augmentation of the nasal dorsum using an "L"-shaped ePTFE and subperiosteal implantation of an inverted "m"-shaped ePTFE at the base of the piriform aperture...
July 5, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28702490/sigma-2-receptor-ligands-qsar-model-dataset
#18
Antonio Rescifina, Giuseppe Floresta, Agostino Marrazzo, Carmela Parenti, Orazio Prezzavento, Giovanni Nastasi, Maria Dichiara, Emanuele Amata
The data have been obtained from the Sigma-2 Receptor Selective Ligands Database (S2RSLDB) and refined according to the QSAR requirements. These data provide information about a set of 548 Sigma-2 (σ2) receptor ligands selective over Sigma-1 (σ1) receptor. The development of the QSAR model has been undertaken with the use of CORAL software using SMILES, molecular graphs and hybrid descriptors (SMILES and graph together). Data here reported include the regression for σ2 receptor pKi QSAR models. The QSAR model was also employed to predict the σ2 receptor pKi values of the FDA approved drugs that are herewith included...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28697723/implementation-fidelity-of-a-self-management-course-for-epilepsy-method-and-assessment
#19
G Wojewodka, S Hurley, S J C Taylor, A J Noble, L Ridsdale, L H Goldstein
BACKGROUND: Complex interventions such as self-management courses are difficult to evaluate due to the many interacting components. The way complex interventions are delivered can influence the effect they have for patients, and can impact the interpretation of outcomes of clinical trials. Implementation fidelity evaluates whether complex interventions are delivered according to protocol. Such assessments have been used for one-to-one psychological interventions; however, the science is still developing for group interventions...
July 11, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28689904/correlation-between-iris-diameter-and-the-width-of-the-maxillary-central-incisor-with-digital-image-analysis
#20
Kumaravel Hemalatha, Naveen Gopi Chander, Kuttae Vishwanathan Anitha
STATEMENT OF PROBLEM: Various methods have been suggested for determining the width of maxillary anterior teeth for complete dentures. A straightforward and reliable technique for anterior tooth selection in complete denture is still needed. PURPOSE: The purpose of this clinical study was to determine the correlation between the horizontal visible iris diameter (HVID) of the eye and the mesiodistal width of the maxillary central incisor tooth in a dentate Indian population...
July 7, 2017: Journal of Prosthetic Dentistry
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