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zebrafish katp channels

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https://www.readbyqxmd.com/read/25993315/synergistic-potentials-of-coffee-on-injured-pancreatic-islets-and-insulin-action-via-katp-channel-blocking-in-zebrafish
#1
Youn Hee Nam, Bin Na Hong, Isabel Rodriguez, Min Gun Ji, Keonwoo Kim, Ung-Jin Kim, Tong Ho Kang
Pancreatic islets (PIs) are damaged under diabetic conditions, resulting in decreased PI size. This study examined the regenerative effects of coffee and its components (caffeine, CFI; trigonelline, TRG; chlorogenic acid, CGA) on zebrafish larval PIs and β-cells damaged by administration of alloxan (AX). In addition, the influence of coffee and its active components on KATP channels was investigated using diazoxide (DZ) as a KATP channel activator. PI size and fluorescence intensity were significantly increased in the coffee-treated group relative to the no-treatment group (P < 0...
June 17, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/24473439/overnutrition-induces-%C3%AE-cell-differentiation-through-prolonged-activation-of-%C3%AE-cells-in-zebrafish-larvae
#2
Mingyu Li, Lisette A Maddison, Patrick Page-McCaw, Wenbiao Chen
Insulin from islet β-cells maintains glucose homeostasis by stimulating peripheral tissues to remove glucose from circulation. Persistent elevation of insulin demand increases β-cell number through self-replication or differentiation (neogenesis) as part of a compensatory response. However, it is not well understood how a persistent increase in insulin demand is detected. We have previously demonstrated that a persistent increase in insulin demand by overnutrition induces compensatory β-cell differentiation in zebrafish...
April 1, 2014: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/16317080/identification-and-characterization-of-a-novel-member-of-the-atp-sensitive-k-channel-subunit-family-kir6-3-in-zebrafish
#3
Changliang Zhang, Takashi Miki, Tadao Shibasaki, Masaaki Yokokura, Atsunori Saraya, Susumu Seino
ATP-sensitive K+ (KATP) channels play a crucial role in coupling cellular metabolism to membrane potential. In addition to the orthologs corresponding to Kir6.1 and Kir6.2 of mammals, we have identified a novel member, designated Kir6.3 (zKir6.3), of the inward rectifier K+ channel subfamily Kir6.x in zebrafish. zKir6.3 is a protein of 432 amino acids that shares 66% identity with mammalian Kir6.2 but differs considerably from mammalian Kir6.1 and Kir6.2 in the COOH terminus, which contain an Arg-Lys-Arg (RKR) motif, an endoplasmic reticulum (ER) retention signal...
February 14, 2006: Physiological Genomics
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