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https://www.readbyqxmd.com/read/28813109/assessment-of-inhibitory-control-in-crack-and-or-cocaine-users-a-systematic-review
#1
Fernanda Rasch Czermainski, Alice Rodrigues Willhelm, Álvaro Zaneti Santos, Mayra Pacheco Pachado, Rosa Maria Martins de Almeida
Objective: Impairments involving inhibitory control have been considered central deficits in drug users, but it appears that dysfunctions may be specific to users' drug of choice. This article aims to review recent findings on inhibitory control impairment in samples of crack and/or cocaine users. Methods: Searches were conducted on the PubMed, PsycINFO, and Web of Knowledge databases in two stages according to eligibility criteria. Initially, databases were searched and the titles and abstracts of results were analyzed and then selected articles were read in full...
August 14, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28810125/cheminformatic-analysis-of-anti-malarial-chemical-space-illuminates-therapeutic-mechanisms-and-offers-strategies-for-therapy-development
#2
Julia Nogueira Varela, María Fernanda Fernanda Lammoglia Cobo, Sandip V Pawar, Vikramaditya G Yadav
The clear and present danger of malaria, which has been amplified in recent years by climate change, and the progressive thinning of our drug arsenal over the past two decades raise uncomfortable questions about the current state and future of anti-malarial drug development. Besides suffering from many of the same technical challenges that affect drug development in other disease areas, the quest for new anti-malarial therapies is also hindered by the complex, dynamic life cycle of the malaria parasite, P. falciparum, in its mosquito and human hosts, and its role thereof in the elicitation of drug resistance...
August 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28808636/in-vivo-assessment-of-accuracy-of-propex-ii-root-zx-ii-and-radiographic-measurements-for-location-of-the-major-foramen
#3
Fernanda Garcia Tampelini, Marcelo Santos Coelho, Marcos de Azevêdo Rios, Carlos Eduardo Fontana, Daniel Guimarães Pedro Rocha, Sergio Luiz Pinheiro, Carlos Eduardo da Silveira Bueno
OBJECTIVES: The aim of this in vivo study was to assess the accuracy of 2 third-generation electronic apex locators (EALs), Propex II (Dentsply Maillefer) and Root ZX II (J. Morita), and radiographic technique for locating the major foramen (MF). MATERIALS AND METHODS: Thirty-two premolars with single canals that required extraction were included. Following anesthesia, access, and initial canal preparation with size 10 and 15 K-flex files and SX and S1 rotary ProTaper files, the canals were irrigated with 2...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28807655/first-clinical-consensus-and-national-recommendations-on-tracheostomized-children-of-the-brazilian-academy-of-pediatric-otorhinolaryngology-abope-and-brazilian-society-of-pediatrics-sbp
#4
Melissa A G Avelino, Rebecca Maunsell, Fabiana Cardoso Pereira Valera, José Faibes Lubianca Neto, Cláudia Schweiger, Carolina Sponchiado Miura, Vitor Guo Chein, Dayse Manrique, Raquel Oliveira, Fabiano Gavazzoni, Isabela Furtado de Mendonça Picinin, Paulo Bittencourt, Paulo Camargos, Fernanda Peixoto, Marcelo Braciela Brandão, Tania Maria Sih, Wilma Terezinha Anselmo-Lima
INTRODUCTION: Tracheostomy is a procedure that can be performed in any age group, including children under 1year of age. Unfortunately health professionals in Brazil have great difficulty dealing with this condition due to the lack of standard care orientation. OBJECTIVE: This clinical consensus by Academia Brasileira de Otorrinolaringologia Pediátrica (ABOPe) and Sociedade Brasileira de Pediatria (SBP) aims to generate national recommendations on the care concerning tracheostomized children...
June 27, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28807400/incx3-plasmid-harboring-a-non-tn4401-genetic-element-ntekpc-in-a-hospital-associated-clone-of-kpc-2-producing-klebsiella-pneumoniae-st340-cg258
#5
Louise T Cerdeira, Marcos P V Cunha, Gabriela R Francisco, Maria Fernanda C Bueno, Bruna F Araujo, Rosineide M Ribas, Paulo P Gontijo-Filho, Terezinha Knöbl, Doroti de Oliveira Garcia, Nilton Lincopan
IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most blaKPC- and blaNDM-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTEKPC) of tnpR-tnpA (partial)-blaKPC-2-ΔISKpn6/traN, originating from a hospital-associated lineage of K...
July 1, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28807284/first-description-of-cryptosporidium-parvum-in-carrier-pigeons-columba-livia
#6
Bruno César Miranda Oliveira, Elis Domingos Ferrari, Mariele Fernanda da Cruz Panegossi, Alex Akira Nakamura, Flávio Sader Corbucci, Walter Bertequini Nagata, Bianca Martins Dos Santos, Jancarlo Ferreira Gomes, Marcelo Vasconcelos Meireles, Giovanni Widmer, Katia Denise Saraiva Bresciani
The carrier pigeon and the domestic pigeon are different breeds of the species Columba livia. Carrier pigeons are used for recreational activities such as bird contests and exhibitions. Due to the close contact with humans, these birds may potentially represent a public health risk, since they can host and disseminate zoonotic parasites, such as those belonging to the genus Cryptosporidium (phylum Apicomplexa). The purpose of this work was the detection by microscopic and molecular techniques of Cryptosporidium spp...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28806559/assessment-of-chemicals-released-in-the-marine-environment-by-dielectric-elastomers-useful-as-active-elements-in-wave-energy-harvesters
#7
Mirela-Fernanda Zaltariov, Adrian Bele, Lavinia Vasiliu, Luiza Gradinaru, Nicoleta Vornicu, Carmen Racles, Maria Cazacu
A series of elastomers, either natural or synthetic (some of them commercial, while others prepared in the laboratory), suitable for use as active elements in devices for wave energy harvesting, were evaluated concerning their behavior and effects on the marine environment. In this aim, the elastomer films, initially evaluated regarding their aspect, structure, surface wettability, and tolerance of microorganisms growth, were immersed in synthetic seawater (SSW) within six months for assessing compounds released...
August 4, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28804633/fractalkine-c-x3-c-motif-chemokine-ligand-1-as-a-potential-biomarker-for-depression-and-anxiety-in-colorectal-cancer-patients
#8
Diego Oliveira Miranda, Elen Anatriello, Lucas Ribeiro Azevedo, Jessica Cristina Santos, Jessica Fernanda Correa Cordeiro, Fernanda Maris Peria, Milena Flória-Santos, Gabriela Pereira-Da-Silva
Fractalkine, a unique chemokine of the CX3C subfamily, is involved in the pathogenesis of different types of cancer and also in non-immune mechanisms associated with psychiatric disorders. The aim of the present study was to investigate whether there is a correlation between anxiety, depression and fractalkine serum levels in colorectal cancer (CRC) patients in different stages of antitumor therapy. Four groups of patients undergoing treatment (n=20 per group) were evaluated: Patients with CRC who did not undergo surgical resection of the tumor; patients who underwent resection and who did not start adjuvant therapy; patients undergoing chemotherapy for ~3 months; and patients who had completed adjuvant chemotherapy regimen for ~6 months...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28803905/azithromycin-treatment-is-able-to-control-the-infection-by-two-genotypes-of-toxoplasma-gondii-in-human-trophoblast-bewo-cells
#9
Mayara Ribeiro, Priscila Silva Franco, Janice Buiate Lopes-Maria, Mariana Bodini Angeloni, Bellisa de Freitas Barbosa, Angelica de Oliveira Gomes, Andressa Silva Castro, Rafaela José da Silva, Fernanda Chaves de Oliveira, Iliana Claudia Balga Milian, Olindo Assis Martins-Filho, Francesca Ietta, José Roberto Mineo, Eloisa Amália Vieira Ferro
Trophoblast infection by Toxoplasma gondii plays a pivotal role in the vertical transmission of toxoplasmosis. Here, we investigate whether the antibiotic therapy with azithromycin, spiramycin and sulfadiazine/pyrimethamine are effective to control trophoblast infection by two Brazilian T. gondii genotypes, TgChBrUD1 or TgChBrUD2. Two antibiotic protocols were evaluated, as follow: i) pre-treatment of T. gondii-tachyzoites with selected antibiotics prior trophoblast infection and ii) post-treatment of infected trophoblasts...
August 10, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28803133/predictive-value-of-multiple-cytokines-and-chemokines-for-mortality-in-an-admixed-population-15-year-follow-up-of-the-bambui-epigen-brazil-cohort-study-of-aging
#10
Maria Fernanda Lima-Costa, Juliana Vaz de Melo Mambrini, Karen Cecília de Lima Torres, Sérgio Viana Peixoto, Cesar de Oliveira, Eduardo Tarazona-Santos, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho
Inflammation, particularly elevated IL-6 serum levels, has been associated with increased mortality risk, mostly in Caucasians. The influence of genetic ethno-racial background on this association is unknown. We examined associations between baseline serum levels of Interleukin-6 (IL-6) and other cytokines (IL1-2, TNF, IL-10, and IL1β) and chemokines (CCL2, CCL5, CXCL8, CXCL9 and CXCL10) with 15-year mortality in 1,191 admixed Brazilians aged 60years and over. Elevated IL6 level (but not other biomarkers) was associated with increased risk of deaths with fully adjusted hazard ratios of 1...
August 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28803094/brief-psychoeducation-for-bipolar-disorder-evaluation-of-trophic-factors-serum-levels-in-young-adults
#11
Carolina David Wiener, Mariane Lopez Molina, Fernanda Pedrotti Moreira, Miguel Bezerra Dos Passos, Karen Jansen, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Jean Pierre Oses
The aim of this study was to evaluate the impact of psychoeducation in serum levels of BDNF, NGF and GDNF in young adults presenting bipolar disorder (BD). This is a randomized clinical trial including 39 young adults (18-29 years) diagnosed with BD through the Structured Clinical Interview for DSM-IV (SCID-CV). Participants were randomized in two treatment groups: usual treatment (medication) and combined intervention (medication plus psychoeducation). Depressive symptoms were assessed using the Hamilton Depression Rating Scale (HDRS) and severity of manic and hypomanic symptoms was evaluated through the Young Mania Rating Scale (YMRS)...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28802239/synergistic-antinociceptive-interaction-of-syzygium-aromaticum-or-rosmarinus-officinalis-coadministered-with-ketorolac-in-rats
#12
Karla Lyzet Beltrán-Villalobos, Myrna Déciga-Campos, Hidemi Aguilar-Mariscal, María Eva González-Trujano, María Fernanda Martínez-Salazar, María de Los Ángeles Ramírez-Cisneros, María Yolanda Rios, Francisco Javier López-Muñoz
Syzygium aromaticum (L.) Merr. & L.M. Perry (Mirtaceae) and Rosmarinus officinalis L. (Lamiaceae) are both medicinal plants used for centuries to alleviate pain. The aim of the study was to demonstrate the therapeutic potential utility of herb-drug association of S. aromaticum essential oil or R. officinalis ethanolic extract coadministered with ketorolac. Antinociceptive pharmacological interaction was investigated by an isbolographic study using the formalin test in rats. Both alone and in combination with ketorolac; S...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28801530/rhythmic-behavior-is-controlled-by-the-srm160-splicing-factor-in-drosophila-melanogaster
#13
Esteban J Beckwith, Carlos E Hernando, Sofía Polcowñuk, Agustina P Bertolin, Estefania Mancini, M Fernanda Ceriani, Marcelo J Yanovsky
Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that modulate these rhythms remain largely unexplored. A genome-wide assessment of the alterations of gene expression in a null mutant of the alternative splicing regulator SR-related matrix protein of 160 kD (SRm160) revealed the extent to which alternative splicing impacts on behavior-related genes...
August 11, 2017: Genetics
https://www.readbyqxmd.com/read/28801090/leptin-concentrations-and-scd-1-indices-in-classical-homocystinuria-evidence-for-the-role-of-sulfur-amino-acids-in-the-regulation-of-lipid-metabolism
#14
Soraia Poloni, Poli Mara Spritzer, Roberta H Mendes, Vânia D'almeida, Kamila Castro, Fernanda Sperb-Ludwig, Johanna Kugele, Sara Tucci, Henk J Blom, Ida V D Schwartz
BACKGROUND: We describe body composition, lipid metabolism and Stearoyl-CoA desaturase-1 (SCD-1) indices in patients with classical homocystinuria (HCU). METHODS: Eleven treated HCU patients and 16 healthy controls were included. Body composition and bone mineral density were assessed by dual X-ray absorptiometry. Sulfur-containing amino acids (SAA) and their derivatives (total homocysteine, cysteine, methionine, S-adenosylmethionine, S-adenosylhomocysteine, and glutathione), lipids (free fatty acids, acylcarnitines, triglycerides and lipoproteins), glucose, insulin, leptin, adiponectin, and isoprostanes were measured in plasma...
August 8, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28800709/the-major-outer-membrane-protein-mopb-is-required-for-twitching-movement-and-affects-biofilm-formation-and-virulence-in-two-xylella-fastidiosa-strains
#15
Hongyu Chen, Prem Prasad Kandel, Luisa Fernanda Cruz, Paul Anthony Cobine, Leonardo De La Fuente
MopB is a major outer membrane protein in Xylella fastidiosa, a bacterial plant pathogen that causes losses on many economically important crops. Based on in silico analysis, the uncharacterized MopB protein of X. fastidiosa contains a β-barrel structure with an OmpA-like domain and a predicted calcium-binding motif. Here, MopB function was studied by mutational analysis taking advantage of the natural competence of X. fastidiosa. Mutants of mopB were constructed in two different X. fastidiosa strains, the type strain 'Temecula' and the more virulent 'WM1-1'...
August 11, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28800692/does-the-developmental-stage-and-composition-of-riparian-forest-stand-affect-ecosystem-functioning-in-streams
#16
Sahadevan Seena, Francisco Carvalho, Fernanda Cássio, Cláudia Pascoal
A common watershed restoration practice to improve water quality and stream ecosystem functions and services is replanting riparian corridors with plant species that may differ from those of natural communities. This restoration practice may have consequences on the aquatic ecosystem processes because organisms obtain energy from leaf litter inputs of the riparian zones. Leaf litter decomposition in streams is a vital ecosystem-level process, which depends on the activity of microorganisms and invertebrates...
August 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28799895/arginine-and-aerobic-training-prevent-endothelial-and-metabolic-alterations-in-rats-at-high-risk-for-the-development-of-the-metabolic-syndrome
#17
Renata F Medeiros, Thaiane G Gaique, Thais Bento-Bernardes, Raquel Kindlovits, Tamiris M B Gomes, Nadia Alice V Motta, Fernanda Carla Brito, Caroline Fernandes-Santos, Karen J Oliveira, Antonio Claudio L Nóbrega
Endothelial function is a key mechanism in the development of CVD. Arginine and exercise are important non-pharmacological strategies for mitigating the impact of metabolic changes in the metabolic syndrome, but the effect of their combined administration is unknown. Thus, the aim of this study was to investigate the isolated and combined effects of aerobic training and arginine supplementation on metabolic variables and vascular reactivity in rats at high risk for developing the metabolic syndrome. Wistar rats were divided into two groups: control and fructose (F - water with 10 % fructose)...
July 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28799345/positron-and-electron-scattering-by-glycine-and-alanine-shape-resonances-and-methylation-effect
#18
Fernanda B Nunes, Márcio H F Bettega, Sergio d'Almeida Sanchez
We report integral cross sections (ICSs) for both positron and electron scattering by glycine and alanine amino acids. These molecules differ only by a methyl group. We computed the scattering cross sections using the Schwinger multichannel method for both glycine and alanine in different levels of approximation for both projectiles. The alanine ICSs are greater in magnitude than the glycine ICSs for both positron and electron scattering, probably due to the larger size of the molecule. In electron scattering calculations, we found two resonances for each molecule...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28798803/preparation-of-a-nanoemulsion-with-carapa-guianensis-aublet-meliaceae-oil-by-a-low-energy-solvent-free-method-and-evaluation-of-its-preliminary-residual-larvicidal-activity
#19
Flávia L M Jesus, Fernanda B de Almeida, Jonatas L Duarte, Anna E M F M Oliveira, Rodrigo A S Cruz, Raimundo N P Souto, Ricardo M A Ferreira, Regina Gendzelevski Kelmann, José C T Carvalho, Ana C Lira-Guedes, Marcelino Guedes, Conxita Solans, Caio P Fernandes
Andiroba (Carapa guianensis) seeds are the source of an oil with a wide range of biological activities and ethnopharmacological uses. However, few studies have devoted attention to innovative formulations, including nanoemulsions. The present study aimed to obtain a colloidal system with the andiroba oil using a low-energy and organic-solvent-free method. Moreover, the preliminary residual larvicidal activity of the nanoemulsion against Aedes aegypti was evaluated. Oleic and palmitic acids were the major fatty acids, in addition to the phytosterol β-sitosterol and limonoids (tetranortriterpenoids)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28798182/draft-genome-sequences-of-yersinia-frederiksenii-yersinia-intermedia-and-yersinia-kristensenii-strains-from-brazil
#20
Priscilla Fernanda Martins Imori, Fábio Campioni, Guojie Cao, George Kastanis, Maria Sanchez Leon, Marc William Allard, Juliana Pfrimer Falcão
Yersinia enterocolitica-like strains are usually understudied. In this work, we reported the draft genome sequences of two Yersinia frederiksenii, two Yersinia intermedia, and two Yersinia kristensenii strains isolated from humans, animals, food, and the environment in Brazil. These draft genomes will provide better molecular characterizations of these species.
August 10, 2017: Genome Announcements
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