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https://www.readbyqxmd.com/read/29677533/proresolving-protein-annexin-a1-the-role-in-type-2-diabetes-mellitus-and-obesity
#1
Nathalia T Pietrani, Cláudia N Ferreira, Kathryna F Rodrigues, Luiza O Perucci, Fernanda S Carneiro, Adriana A Bosco, Marina C Oliveira, Solange S Pereira, Antônio L Teixeira, Jacqueline I Alvarez-Leite, Adaliene V Ferreira, Lirlândia P Sousa, Karina B Gomes
BACKGROUND: Annexin A1 (AnxA1) is a protein involved in inflammation resolution that might be altered in obesity-associated type 2 diabetes mellitus (DM), which is a chronic inflammatory disease. The aim of this study was to evaluate AnxA1 serum levels in individuals with and without DM stratified according to the body mass index (BMI), and the dynamic of AnxA1 expression in adipose tissue from humans with obesity and non-obesity. METHODS: Serum samples were obtained from 41 patients with DM (lean, overweight and obese) and 40 controls, and adipose tissue samples were obtained from 16 individuals with obesity (with or without DM), and 15 controls...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677186/morphophysiological-changes-in-the-splenic-extracellular-matrix-of-leishmania-infantum-naturally-infected-dogs-is-associated-with-alterations-in-lymphoid-niches-and-the-cd4-t-cell-frequency-in-spleens
#2
Aurea Virginia Andrade da Silva, Fabiano Borges Figueiredo, Rodrigo Caldas Menezes, Arthur Augusto Mendes-Junior, Luisa Helena Monteiro de Miranda, Elisa Cupolillo, Renato Porrozzi, Fernanda Nazaré Morgado
The spleen is one of the main affected organs in canine visceral leishmaniasis (CVL). Disorganization of the splenic white pulp (SWP) has been associated with immunosuppression and disease progression. This study aims to assess structural and cellular changes in the splenic extracellular matrix of dogs with CVL, correlating these changes with the parasite load and clinical signs. Splenic fragments were collected from 41 naturally infected animals for parasite load quantification by quantitative PCR, histopathological analysis and immunohistochemistry for CD3+, CD4+, and CD8+ T cells; CD21+ B cells; Ki-67+, IFN-γ+, and IL-10+ cells; and the MMP-9 and ADAM-10 enzymes...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29676866/detecci%C3%A3-n-y-expresi%C3%A3-n-de-superant%C3%A3-genos-y-de-resistencia-antimicrobiana-en-aislamientos-obtenidos-de-mujeres-portadoras-de-staphylococcus-aureus-que-cuidan-y-alimentan-ni%C3%A3-os
#3
Yina Marcela Guaca-González, Gladys Fernanda Flórez-Restrepo, José Ignacio Moncayo-Ortíz, Jorge Santacruz-Ibarra, Adalucy Álvarez-Aldana
Introducción. Staphylococcus aureus coloniza mucosas y piel, y causa graves infecciones en el hombre y los animales. Es importante establecer el estatus de portadoras de cepas enterotoxigénicas de este microorganismo en manipuladoras de alimentos, con el fin de prevenir intoxicaciones alimentarias.Objetivo. Establecer las correlaciones entre los genes de enterotoxinas clásicas, el gen tsst-1, la producción de toxinas en cultivo y la resistencia antimicrobiana en aislamientos de S. aureus provenientes de manipuladoras de alimentos que cuidan niños en sus comunidades...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29676607/meeting-report-iups-and-adinstruments-2017-teaching-workshop
#4
Fernanda Klein Marcondes, Lais Tono Cardozo, Kelly Cristina Gaviao Luchi, Muhammad Irfannuddin, Christina Karatzaferi, Maria José Rocha, Robert G Carroll
Every 4 yr, the International Union of Physiological Sciences (IUPS) Teaching Workshop is held as a traditional satellite event of the IUPS Congress. The 2017 satellite workshop was held August 5-8, 2017 in Búzios, Rio de Janeiro, Brazil. The workshop provided an opportunity for discussion and experiences in physiology teaching for educators at various levels, graduate students, and undergraduate students. This report describes the workshop activities and reports the participants' perceptions of this event...
June 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29676198/blockade-of-at1-type-receptors-for-angiotensin-ii-prevents-cardiac-microvascular-fibrosis-induced-by-chronic-stress-in-sprague-dawley-rats
#5
Lília Taddeo Firoozmand, Andrea Sanches, Nilsa Regina Damaceno-Rodrigues, Juliana Dinéia Perez, Danielle Sanches Aragão, Rodolfo Mattar Rosa, Fernanda Klein Marcondes, Dulce Elena Casarini, Elia Garcia Caldini, Tatiana Sousa Cunha
To test the effects of chronic-stress on the cardiovascular system, the model of chronic mild unpredictable stress (CMS) has been widely used. The CMS protocol consists of the random, intermittent, and unpredictable exposure of laboratory animals to a variety of stressors, during 3 consecutive weeks. In this study, we tested the hypothesis that exposure to the CMS protocol leads to left ventricle microcirculatory remodeling that can be attenuated by angiotensin II receptor blockade. Male Sprague-Dawley rats were randomly assigned into four groups: Control, Stress, Control + losartan, and Stress + losartan (N = 6, each group, losartan: 20 mg/kg/day)...
April 20, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29675005/effects-of-acetone-fraction-from-buchenavia-tomentosa-aqueous-extract-and-gallic-acid-on-candida-albicans-biofilms-and-virulence-factors
#6
Guilherme R Teodoro, Aline V L Gontijo, Marcos J Salvador, Márcia H Tanaka, Fernanda L Brighenti, Alberto C B Delbem, Ádina C B Delbem, Cristiane Y Koga-Ito
A promising anti- Candida activity of Buchenavia tomentosa extracts was recently described. In the present work, experiments were carried out to determine the fraction with higher antifungal activity from a B. tomentosa extract. Acetone fraction (AF) was obtained from the aqueous extract from dried leaves (5 min/100°C) and it was the most effective one. Gallic acid (GA) was identified by electrospray ionization mass spectrometry (ESI-MS) and also chosen to perform antifungal tests due to its promising activity on Candida albicans ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674506/diagnostic-and-prognostic-roles-of-circulating-exosomal-micrornas-in-acquired-aplastic-anemia-and-myelodysplastic-syndromes
#7
Valentina Giudice, Lauren G Banaszak, Fernanda Gutierrez-Rodrigues, Sachiko Kajigaya, Reema Panjwani, Maria Del Pilar Fernandez Ibanez, Olga Rios, Christopher K Bleck, Erin S Stempinski, Diego Quinones Raffo, Danielle M Townsley, Neal S Young
Exosomal microRNAs modulate cancer cell metabolism and the immune response. Specific exosomal microRNAs have been reported to be reliable biomarkers of several solid and hematologic malignancies. We examined the possible diagnostic and prognostic values of exosomal microRNAs in two human bone marrow failure diseases, aplastic anemia and myelodysplastic syndromes. After screening of 372 microRNAs in a discovery set (n=42) of plasma exosome samples, we constructed a custom microRNA PCR plate, including 42 microRNAs, for validation in a larger cohort (n=99), and we identified 25 differentially expressed exosomal microRNAs uniquely or frequently present in aplastic anemia and/or myelodysplastic syndromes...
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29674111/pre-operative-factors-associated-with-increased-mortality-in-elderly-patients-with-a-hip-fracture-a-cohort-study-in-a-developing-country
#8
Kristian A Espinosa, Amparo Gómez Gélvez, Liliana P Torres, María Fernanda García, Omar R Peña
BACKGROUND: Hip fractures are a public health problem worldwide, and several factors are involved with post-operative mortality. The aim of this study was to identify the pre-operative factors associated with increased mortality in elderly patients with hip fractures in a developing country during the first post-operative year. METHODS: An ambidirectional cohort study was conducted with patients ≥ 65 years of age who underwent hip surgery due to a hip fracture caused by a fall from a standing position...
April 13, 2018: Injury
https://www.readbyqxmd.com/read/29673610/low-exertional-inspiratory-capacity-is-not-related-to-dynamic-inspiratory-muscle-weakness-in-heart-failure
#9
Franciele Plachi, Fernanda Machado Balzan, Ricardo Gass, Rui Gustavo Dorneles, Reisi Zambiazi, Danton Pereira da Silva, Paulo R Sanches, Nadine Oliveira Clausell, Danilo C Berton
Reduction in inspiratory capacity (IC) during exercise has been reported in chronic heart failure (CHF). Since inspiratory muscle dysfunction may be present to a variable degree, the assumption that IC reduction during exercise represents an increase in end-expiratory lung volume must be made with caution. This interpretation is flawed if patients develop dynamic inspiratory muscle strength reduction, i.e., progressively lower esophageal (Pes) pressures as the IC maneuvers are repeated. Sixteen CHF patients and 9 age-matched controls performed an incremental exercise test with serial IC and respiratory pressure measurements...
April 16, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29673501/association-of-sarcopenia-with-nutritional-parameters-quality-of-life-hospitalization-and-mortality-rates-of-elderly-patients-on-hemodialysis
#10
Juliana Giglio, Maria Ayako Kamimura, Fernando Lamarca, Juliana Rodrigues, Fernanda Santin, Carla Maria Avesani
OBJECTIVE: This study aimed to assess whether diminished muscle mass, diminished muscle strength, or both conditions (sarcopenia) are associated with worse nutritional status, poor quality of life (QoL), and hard outcomes, such as hospitalization and mortality, in elderly patients on maintenance hemodialysis (MHD). DESIGN AND SUBJECTS: This is a multicenter observational longitudinal study that included 170 patients on MHD (age 70 ± 7 years, 65% male) from 6 dialysis centers...
May 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29673030/dengue-fever-and-aedes-aegypti-in-indigenous-brazilians-seroprevalence-risk-factors-knowledge-and-practices
#11
Luciano Pamplona de Góes Cavalcanti, Rafael Henrique Machado Sacramento, Fernanda Montenegro de Carvalho Araújo, Danielle Malta Lima, Carlos Carlos Henrique Alencar, Victor Emanuel Pessoa Martins, Lucas Venâncio Araújo, Tais Castelo de Oliveira
OBJECTIVE: Dengue remains an important public health problem in Brazil. We estimated the associated factors of dengue seroprevalence among native Indians of the Tremembé ethnic and their knowledge about the aspects related to the presence of mosquitoes of the genus Aedes. METHODS: An analytical cross-sectional study and a prospective environmental study to monitor the trapping of mosquito eggs monthly were performed. The serological portion of the study involved indigenous people living in the village of Tapera in northeastern Brazil...
April 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29671677/health-promotion-practices-in-primary-care-groups
#12
Ivonete Teresinha Schulter Buss Heidemann, Maria Fernanda Baeta Neves Alonso da Costa, Patrícia Madalena Vieira Hermida, Cláudia Cossentino Bruck Marçal, Fabiano Oliveira Antonini, Camilla Costa Cypriano
This is a descriptive-exploratory study using a qualitative approach, conducted in ten municipalities in southern Brazil. Data were obtained by talking to 21 nurses from February to November 2012, through semi-structured interviews using questions to probe their health promotion practices. Data were analyzed through thematic analysis focused on health promotion concepts. We identified four themes about health promotion practices of family health nurses in Brazil: a) training of nurses for health promotion practice was weak; b) nurses formed health promotion groups around diseases and life stages; c) nurses formed groups to meet community needs; and d) nurses used health promotion techniques in group work...
April 1, 2018: Global Health Promotion
https://www.readbyqxmd.com/read/29671631/antimicrobial-sonodynamic-and-photodynamic-therapies-against-candida-albicans
#13
Fernanda Alves, Ana Cláudia Pavarina, Ewerton Garcia de Oliveira Mima, Anthony P McHale, John Francis Callan
Candida albicans biofilms exhibit unique characteristics and are highly resistant to antifungal agents. Antimicrobial photodynamic therapy (aPDT) is an alternative treatment limited to treating superficial infections due to the poor light penetration. In this manuscript, the antifungal properties of sonodynamic therapy (SDT) were assessed. SDT uses ultrasound instead of light, enabling the treatment of deeper infections. Planktonic cells and biofilms of C. albicans were treated with aPDT or SDT, in addition to combined aPDT/SDT, with cell survival determined using colony forming units...
April 19, 2018: Biofouling
https://www.readbyqxmd.com/read/29671197/distinct-response-to-gdf15-knockdown-in-pediatric-and-adult-glioblastoma-cell-lines
#14
Mirella Baroni, Suely Kazue Nagahashi Marie, Paola Fernanda Fedatto, Augusto Faria Andrade, Veridiana Kill Suazo, Gustavo Alencastro Veiga Cruzeiro, Rosane de Paula Queiroz, Luiz Gonzaga Tone, Carlos Alberto Scrideli
INTRODUCTION: Glioblastoma (GBM) is the most common malignant primary brain tumor affecting adults. In pediatric patients, GBM exhibits genetic variations distinct from those identified in the adult GBM phenotype. This tumor exhibits complex genetic changes leading to malignant progression and resistance to standard therapies including radiotherapy and temozolomide treatment. The GDF15 gene codes for a growth factor whose expression is altered in the presence of inflammations and malignancies...
April 18, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29671120/retraction-note-to-compensatory-role-of-the-nbcn1-sodium-bicarbonate-cotransporter-on-ca-2-induced-mitochondrial-swelling-in-hypertrophic-hearts
#15
Lorena A Vargas, Fernanda Carrizo Velasquez, Bernardo V Alvarez
The authors have retracted this article [1] because of modifications in the control lanes of Figs. 2a and 8a of the COX1 blot obtained for 18-week-old rats (rotation, horizontal flipping and re-use of the control lanes for the 35-week-old rats blot). In light of the concerns raised, the conclusions drawn in this article cannot be relied upon.
April 18, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29670630/helminth-infections-recognition-and-modulation-of-the-immune-response-by-innate-immune-cells
#16
REVIEW
Claudia Cristina Motran, Leonardo Silvane, Laura Silvina Chiapello, Martin Gustavo Theumer, Laura Fernanda Ambrosio, Ximena Volpini, Daiana Pamela Celias, Laura Cervi
The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the release of danger signals that induce the recruitment of various cells, including innate immune cells such as macrophages (Mo), dendritic cells (DCs), eosinophils, basophils, and mast cells. In this scenario, these cells are able to secrete soluble factors, which orchestrate immune effector mechanisms that depend on the different niches these parasites inhabit...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670574/editorial-new-advanced-wireless-technologies-for-objective-monitoring-of-motor-symptoms-in-parkinson-s-disease
#17
EDITORIAL
Fernanda Irrera, Joan Cabestany, Antonio Suppa
No abstract text is available yet for this article.
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29669110/chronic-occupational-exposure-endured-by-tobacco-farmers-from-brazil-and-association-with-dna-damage
#18
Vívian F Silva Kahl, Varinderpal Singh Dhillon, Daniel Simon, Fernanda Rabaioli da Silva, Mirian Salvador, Cátia Dos Santos Branco, Mónica Cappetta, Wilner Martínez-López, Flávia V Thiesen, Johnny F Dias, Claudia Telles de Souza, Michael Fenech, Juliana da Silva
Tobacco farming is an important economic income in Brazil, although it has been challenged as regard the occupational exposure to both pesticides and nicotine endured by farmers. Chronic occupational exposure to complex mixtures can lead to health hazardous. We examined genomic instability and epigenetic changes in tobacco farmers occupationally exposed to pesticide mixtures and nicotine at tobacco fields. DNA damage was assessed by alkaline comet assay in blood cells. Genomic DNA was isolated, and telomere length was measured using quantitative polymerase chain reaction assay...
April 13, 2018: Mutagenesis
https://www.readbyqxmd.com/read/29668817/adverse-events-of-vaccines-and-the-consequences-of-non-vaccination-a-critical-review
#19
Luana Raposo de Melo Moraes Aps, Marco Aurélio Floriano Piantola, Sara Araujo Pereira, Julia Tavares de Castro, Fernanda Ayane de Oliveira Santos, Luís Carlos de Souza Ferreira
OBJECTIVE: To analyze the risks related to vaccines and the impacts of non-vaccination on the world population. METHODS: This is a narrative review that has considered information present in the bibliographic databases NCBI-PubMed, Medline, Lilacs, and Scientific Electronic Library Online (SciELO), between November 2015 and November 2016. For the analysis of outbreaks caused by non-vaccination, we considered the work published between 2010 and 2016. RESULTS: We have described the main components of the vaccines offered by the Brazilian public health system and the adverse events associated with these elements...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29668805/influence-of-hesperidin-and-vitamin-c-on-glycemic-parameters-lipid-profile-and-dna-damage-in-rats-treated-with-sucrose-overload
#20
Silvia I R Franke, Patrícia Molz, Camila Mai, Joel H Ellwanger, Fernanda F Zenkner, Jorge A Horta, Daniel Prá
We evaluated the influence of hesperidin and vitamin C (VitC) on glycemic parameters, lipid profile, and DNA damage in male Wistar rats treated with sucrose overload. Rats were divided into six experimental groups: I-water control; II-sucrose control; III-hesperidin control; IV-VitC control; V-co-treatment of sucrose plus hesperidin; VI-co-treatment of sucrose plus VitC. We measured the levels of triglycerides, total cholesterol, HDL-c, LDL-c, fasting glucose, and glycated hemoglobin (A1C). DNA damage was evaluated in blood and brain cells using the comet assay and the micronucleus test was used to evaluate chromosomal damages in the rat bone marrow...
April 16, 2018: Anais da Academia Brasileira de Ciências
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