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https://www.readbyqxmd.com/read/28097856/-transition-experience-of-patients-with-neuromuscular-disease
#1
Valeria Greif, Florencia Ugo, M Fernanda de Castro Pérez, Julieta Mozzoni, Verónica Aguerre, Milagros Saldías, M Soledad Monges
Neuromuscular diseases are mostly genetic disorders, with chronic and progressive course. Affected people are at high risk of developing physical and emotional disabilities. In the last decades, the advance in technology and science has increased chronic pediatric patients survival rate, thus requiring an ongoing assistance in adult hospitals, making the transition a necessity and a challenge. This article reports the clinical practice designed between Hospital Garrahan and Hospital Ramos Mejía for the transition of 27 adolescents during 2015, setting achievements, findings and challenges resulting from this experience...
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28097012/pharmacokinetics-and-pharmacodynamics-of-antibiotics-in-critically-ill-acute-kidney-injury-patients
#2
REVIEW
Welder Zamoner, Fernanda M de Freitas, Durval S S Garms, Mariele Gobo de Oliveira, André L Balbi, Daniela Ponce
Sepsis is the most common cause of death in critically ill patients and is associated with multiorgan failure, including acute kidney injury (AKI). This situation can require acute renal support and increase mortality. Therefore, it is essential to administer antimicrobials in doses that achieve adequate serum levels, avoiding both overdosing and drug toxicity as well as underdosing and the risk of antibiotic resistance and higher mortality. Currently, there are no validated guidelines on antibiotic dose adjustments in septic patients with AKI...
December 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28096687/coaching-and-barriers-to-weight-loss-an-integrative-review
#3
REVIEW
Karen Fernanda Muñoz Obino, Caroline Aguiar Pereira, Rafaela Siviero Caron-Lienert
INTRODUCTION: Coaching is proposed to raise a patient's awareness and responsibility for their health behaviour change by transforming the professional-patient relationship. OBJECTIVE: To review the scientific literature on how coaching can assist in weight loss and improve a patient's state of health. METHODOLOGY: An integrative literature search was performed using PubMed, Latin American and Caribbean Literature in Health Sciences, and Scientific Electronic Library Online...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28096433/sex-differences-in-the-development-of-prolactinoma-in-mice-overexpressing-hcg%C3%AE-role-of-tgf%C3%AE-1
#4
Erika Yanil Faraoni, María Andrea Camilletti, Alejandra Inés Abeledo Machado, Laura Daniela Ratner, Fernanda De Fino, Ilpo T Huhtaniemi, Susana B Rulli, Graciela Diaz-Torga
Female transgenic mice that overexpress the human chorionic gonadotrophin β subunit (hCGβ+) develop prolactinomas, while hCGβ+ males do not. The high levels of circulating hCG induces massive luteinization in the ovary of hCGβ+ females, and progesterone becomes the primary steroid hormone produced, but estradiol remains at physiological level. The involvement of high levels of progesterone in lactotroph proliferation is not clearly understood; hence the pathogenesis of prolactinomas in hCGβ+ females remains unclear...
January 17, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28095942/association-of-neighbourhood-food-availability-with-the-consumption-of-processed-and-ultra-processed-food-products-by-children-in-a-city-of-brazil-a-multilevel-analysis
#5
Fernanda Helena Marrocos Leite, Elena de Carvalho Cremm, Débora Silva Costa de Abreu, Maria Aparecida de Oliveira, Nadine Budd, Paula Andrea Martins
OBJECTIVE: To investigate the association between neighbourhood food availability and the consumption of ready-to-consume products (RCP), either processed or ultra-processed, and unprocessed/minimally processed foods (UF-MPF) by children. DESIGN: Cross-sectional. 24 h Dietary recalls were collected from children from January 2010 to June 2011. Neighbourhood food availability data were collected from 672 food stores located within 500 m of participants' homes, using an adapted and validated instrument...
January 18, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28095682/superparamagnetic-nanoparticles-as-high-efficiency-magnetic-resonance-imaging-t2-contrast-agent
#6
Fernanda Sousa, Barbara Sanavio, Alessandra Saccani, Yun Tang, Ileana Zucca, Tamara M Carney, Alfonso Mastropietro, Paulo H Jacob Silva, Randy P Carney, Kurt Schenk, Arash O Omrani, Ping Huang, Lin Yang, Henrik M Rønnow, Francesco Stellacci, Silke Krol
Nanoparticle-based magnetic resonance imaging T2 negative agents are of great interest, and much effort is devoted to increasing cell-loading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, bimetallic gold/iron nanoparticles (Au/Fe NPs) synthesized by a two-step method are presented. Their structure, surface composition, and magnetic properties are characterized. The two classes of sulfonated Au/Fe NPs, with an average diameter of 4 nm, have an average atomic ratio of Au to Fe equal to 7 or 8, which enables the Au/Fe NPs to be superparamagnetic with a blocking temperature of 56 K and 96 K...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28095490/costs-and-tradeoffs-of-resistance-and-tolerance-to-belowground-herbivory-in-potato
#7
Etzel Garrido, Maria Fernanda Díaz, Hugo Bernal, Carlos Eduardo Ñustez, Jennifer Thaler, Georg Jander, Katja Poveda
The success of sustainable crop production depends on our ability to select or create varieties that can allocate resources to both growth and defence. However, breeding efforts have emphasized increases in yields but have partially neglected defence traits against pests. Estimating the costs of multiple defences against tuber herbivores and the tradeoffs among them, as well as understanding the relationship between yield and multiple defences is still unknown but relevant to both basic and applied ecology...
2017: PloS One
https://www.readbyqxmd.com/read/28095484/experimental-diabetes-alters-the-morphology-and-nano-structure-of-the-achilles-tendon
#8
Rodrigo Ribeiro de Oliveira, Rômulo Medina de Mattos, Luciana Magalhães Rebelo, Fernanda Guimarães Meireles Ferreira, Fernanda Tovar-Moll, Luiz Eurico Nasciutti, Gerly Anne de Castro Brito
Although of several studies that associate chronic hyperglycemia with tendinopathy, the connection between morphometric changes as witnessed by magnetic resonance (MR) images, nanostructural changes, and inflammatory markers have not yet been fully established. Therefore, the present study has as a hypothesis that the Achilles tendons of rats with diabetes mellitus (DM) exhibit structural changes. The animals were randomly divided into two experimental groups: Control Group (n = 06) injected with a vehicle (sodium citrate buffer solution) and Diabetic Group (n = 06) consisting of rats submitted to intraperitoneal administration of streptozotocin...
2017: PloS One
https://www.readbyqxmd.com/read/28094218/cribriform-adenocarcinoma-of-the-soft-palate-with-multiple-lymph-node-metastasis-and-long-term-follow-up
#9
Fernanda Viviane Mariano, Renata Freitas Varanda, Luciana Schultz, Marcelo Brum Correa, Oslei Paes de Almeida, Albina Atemani, Márcio Ajudarte Lopes
INTRODUCTION: Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a recently described entity, with most cases previously published as polymorphous low-grade adenocarcinoma (PLGA). Typical cases share some main characteristics, such as oral sites (mainly tongue), regional lymph node metastasis, and morphology resembling solid and follicular variants of papillary thyroid carcinoma. OBJECTIVE: To present a CATMSG and emphasize the importance of reclassifying PLGAs with unusual behavior...
November 1, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28093976/chemoinformatics-profiling-of-the-chromone-nucleus-as-a-mao-b-a2aar-dual-binding-scaffold
#10
Maykel Cruz-Monteagudo, Fernanda Borges, M Natália D S Cordeiroc, Aliuska Morales Helguerad, Eduardo Tejerab, Cesar Paz-Y-Miñob, Aminael Sánchez-Rodrígueze, Yunier Perera-Sardiñaf, Yunierkis Perez-Castillo
BACKGROUND: In the context of the current drug discovery efforts to find disease modifying therapies for Parkinson´s disease (PD) the current single target strategy has proved inefficient. Consequently, the search for multi-potent agents is attracting more and more attention due to the multiple pathogenetic factors implicated in PD. Multiple evidences points to the dual inhibition of the monoamine oxidase B (MAO-B), as well as adenosine A2A receptor (A2AAR) blockade, as a promising approach to prevent the neurodegeneration involved in PD...
January 16, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28093357/are-the-innate-and-adaptive-immune-systems-setting-hypertension-on-fire
#11
REVIEW
Gisele F Bomfim, Fernanda Luciano Rodrigues, Fernando S Carneiro
Hypertension is the most common chronic cardiovascular disease and is associated with several pathological states, being an important cause of morbidity and mortality around the world. Low-grade inflammation plays a key role in hypertension and the innate and adaptive immune systems seem to contribute to hypertension development and maintenance. Hypertension is associated with vascular inflammation, increased vascular cytokines levels and infiltration of immune cells in the vasculature, kidneys and heart. However, the mechanisms that trigger inflammation and immune system activation in hypertension are completely unknown...
January 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28093334/in-vitro-antitumor-and-antiangiogenic-effects-of-bothropoidin-a-metalloproteinase-from-bothrops-pauloensis-snake-venom
#12
Denise de Oliveira Guimarães, Daiana Silva Lopes, Fernanda Van Petten Vasconcelos Azevedo, Sarah Natalie Gimenes, Makswell Almeida Silva, David Collares Achê, Mário Sérgio Rocha Gomes, Lara Vecchi, Luiz Ricardo Goulart, Kelly Aparecida Geraldo Yoneyama, Renata Santos Rodrigues, Veridiana de Melo Rodrigues
Breast cancer is a highly malignant carcinoma and remains the second leading cause of mortality among women. The antitumor effects of metalloproteinases and disintegrins from snake venom on various types of cancer cells have been investigated. In this study, we evaluated the antitumor and antiangiogenic effects on MDA-MB-231 human breast cancer cells and endothelial cells induced by Bothropoidin, a disintegrin-like metalloproteinase isolated from Bothrops pauloensis snake venom. At 24h after treatment at 100μg/mL, Bothropoidin exerted a moderate cytotoxic effect of 30% on MDA-MB-231 versus 10% cytotoxicity against MCF10A (a non-tumorigenic breast cell line), a significant difference that suggests a possible preference by this protein for targets in cancer cells...
January 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28092765/cytotoxic-genotoxic-and-mutagenic-evaluation-of-surface-waters-from-a-coal-exploration-region
#13
Cynthia Silva Porta, Débora Lemes Dos Santos, Hélio Vieira Bernardes, Bruno Corrêa Bellagamba, Anaí Duarte, Johnny Ferraz Dias, Fernanda Rabaioli da Silva, Mauricio Lehmann, Juliana da Silva, Rafael Rodrigues Dihl
Coal mining generates a considerable amount of waste, which is disposed of in piles or dams near mining sites. As a result, leachates may reach rivers and streams, promoting the wide dispersion of contaminants in solution and as particulate matter. The present study evaluated the cytotoxic, genotoxic, and mutagenic action of surface waters collected around a thermoelectric power plant and the largest mining area in Brazil (Candiota). Four sites in Candiota stream were selected, and samples were collected in winter and summer...
January 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28091892/bariatric-roux-en-y-gastric-bypass-surgery-adipocyte-proteins-involved-in-increased-bone-remodeling-in-humans
#14
Maria Fernanda G Biagioni, Adriana L Mendes, Célia Regina Nogueira, Celso V Leite, Loraine Gollino, Gláucia Mfs Mazeto
PURPOSE: Bariatric surgery has been associated with bone remodeling changes. The action of adipokines on the expression of receptor activator of nuclear factor kappa β ligand (RANKL) and osteoprotegerin (OPG) and on an increase in sclerostin could be related to these changes. MATERIALS AND METHODS: This study aimed to assess the repercussions of weight loss, fat mass (FM), and fat-free mass (FFM) loss and biochemical and hormonal changes on bone remodeling markers after Roux-en-Y gastric bypass (RYGB)...
January 13, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28089947/hepatic-xanthine-oxidase-activity-and-purine-nucleosides-levels-as-physiological-mediators-to-analyze-a-subcutaneous-treatment-with-phse-2-in-mice-infected-by-toxoplasma-gondii
#15
Pedro H Doleski, Daniela B R Leal, Vanessa Machado, Nathieli B Bottari, Emerson A Casali, Cesar E J Moritz, Giovana Camillo, Fernanda F Vogel, Lenita M Stefani, Aleksandro Schafer da Silva
The aim of this study was to evaluate the levels of purine nucleosides and xanthine oxidase (XO) activity in the liver of mice chronically infected by Toxoplasma gondii and treated with diphenyl diselenide (PhSe)2. For this experiment, forty Swiss mice were used. Twenty animals were orally infected by approximately 50 bradizoites of a cystogenic ME-49 strain of T. gondii, and the same number of uninfected mice was used as a control group. Ten infected and ten uninfected mice were subcutaneously treated twice (days 1 and 20 post-infection (PI)) with 5 μmol kg(-1) of (PhSe)2...
January 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28089739/the-influence-of-seasonality-on-the-content-of-goyazensolide-and-on-anti-inflammatory-and-anti-hyperuricemic-effects-of-the-ethanolic-extract-of-lychnophora-passerina-brazilian-arnica
#16
Bruno César de Albuquerque Ugoline, Jacqueline de Souza, Fernanda Cristina Ferrari, Zilma Schimith Ferraz Filha, Grazielle Brandão Coelho, Dênia Antunes Saúde-Guimarães
ETHNOPHARMACOLOGICAL RELEVANCE: Lychnophora passerina (Mart ex DC) Gardn (Asteraceae), popularly known as Brazilian arnica, is used in Brazilian folk medicine to treat pain, rheumatism, bruises, inflammatory diseases and insect bites. AIM OF THE STUDY: Investigate the influence of the seasons on the anti-inflammatory and anti-hyperuricemic activities of ethanolic extract of L. passerina and the ratio of the goyazensolide content, main chemical constituent of the ethanolic extract, with these activities...
January 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28088929/morphologic-analysis-of-sperm-from-two-neotropical-primate-species-comparisons-between-the-squirrel-monkeys-saimiri-collinsi-and-saimiri-vanzolinii
#17
Wlaisa V Sampaio, Karol G Oliveira, Danuza L Leão, Maria C Caldas-Bussiere, Helder L Queiroz, Fernanda P Paim, Regiane R Santos, Sheyla F S Domingues
Sperm morphometry can be applied to identify different animal groups and species and to evaluate sperm quality. Furthermore, knowledge on species-specific differences will help to enhance biological information, as well as to develop efficient reproductive technologies. The aims in the present study were to describe sperm morphometry from the recently characterized species S. collinsi and S. vanzolinii, to verify if the morphometric sperm patterns are similar or different between both species, and to determine if the sperm morphometry is affected by the levels of sperm defects using the S...
January 16, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28088247/first-molecular-identification-of-echinococcus-vogeli-and-echinococcus-granulosus-sensu-stricto-g1-revealed-in-feces-of-domestic-dogs-canis-familiaris-from-acre-brazil
#18
Leandro Batista das Neves, Paulo Eduardo Ferlini Teixeira, Sidnei Silva, Fernanda Bittencourt de Oliveira, Daniel Daipert Garcia, Fernanda Barbosa de Almeida, Rosângela Rodrigues-Silva, José Roberto Machado-Silva
BACKGROUND: Echinococcus granulosus (sensu lato) (s.l.) and Echinococcus vogeli are causative agents of chronic zoonotic diseases such as cystic and polycystic echinococcosis, respectively. In Brazil, polycystic echinococcosis has a restricted geographical distribution in the North Region, while cystic echinococcosis is observed in the South Region. Domestic dogs (Canis familiaris) fed with raw viscera represent a risk factor for E. granulosus (s.l.) infection in the South Region. Although this practice is frequent, it remains unclear whether domestic dogs are infected with E...
January 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28087053/six-minute-walk-test-results-predict-risk-of-hospitalization-for-youths-with-cystic-fibrosis-a-5-year-follow-up-study
#19
Márcio V F Donadio, João P Heinzmann-Filho, Fernanda M Vendrusculo, Patrícia X H Frasson, Paulo J C Marostica
OBJECTIVE: To evaluate the association of 6-minute walk test (6MWT) and other variables (anthropometry, chronic Pseudomonas aeroginosa colonization, pulmonary function, and respiratory muscle strength) with the risk of hospitalization for pulmonary exacerbation in children and adolescents with cystic fibrosis (CF). STUDY DESIGN: Cohort study that included patients with CF aged 6-18 years. All participants underwent spirometry, manovacuometry, and 6MWT during the 5-year follow-up...
January 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28081494/a-cockspur-for-the-dss-cells-erythrina-crista-galli-sensitizers
#20
Paula Enciso, Jean-David Decoppet, Michael Grätzel, Michael Wörner, Franco M Cabrerizo, María Fernanda Cerdá
Dye sensitized solar cells were assembled employing a mixture of anthocyanins extracted from red ceibo's flowers. At the literature different extraction procedures are reported to extract anthocyanins from natural products and sensitize the cells. In order to compare them, different methods were followed to set the cells under the same conditions. Assembled cells showed very interesting conversion efficiency values, reaching a 0.73% value for extracts purified using C18 column, in open cells under illumination using a solar light simulator, 1 sun, 1...
January 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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