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Ankylosis spondylitis

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https://www.readbyqxmd.com/read/29090349/bone-disease-in-axial-spondyloarthritis
#1
REVIEW
Margot Van Mechelen, Giulia Rossana Gulino, Kurt de Vlam, Rik Lories
Axial spondyloarthritis is a chronic inflammatory skeletal disorder with an important burden of disease, affecting the spine and sacroiliac joints and typically presenting in young adults. Ankylosing spondylitis, diagnosed by the presence of structural changes to the skeleton, is the prototype of this disease group. Bone disease in axial spondyloarthritis is a complex phenomenon with the coexistence of bone loss and new bone formation, both contributing to the morbidity of the disease, in addition to pain caused by inflammation...
October 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29067775/dual-phase-hybrid-18-f-fluoride-positron-emission-tomography-mri-in-ankylosing-spondylitis-investigating-the-link-between-mri-bone-changes-regional-hyperaemia-and-increased-osteoblastic-activity
#2
Lino M Sawicki, Susanne Lütje, Xenofon Baraliakos, Jürgen Braun, Julian Kirchner, Johannes Boos, Philipp Heusch, Verena Ruhlmann, Ken Herrmann, Lale Umutlu, Harald H Quick, Gerald Antoch, Christian Buchbender
INTRODUCTION: Focal (18) F-Fluoride uptake on blood-pool phase PET represents regional hyperaemia, while it indicates osteoblastic activity on mineralization phase PET. This study investigates the link between regional hyperaemia and osteoblastic activity in inflammatory and chronic lesions of ankylosing spondylitis (AS) of the sacroiliac joints (SIJ) using dual-phase (18) F-Fluoride PET/MRI. METHODS: Thirteen patients (six men, seven women, age: 37 ± 10 years) with active AS prospectively underwent dual-phase (18) F-Fluoride PET/MRI...
October 25, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28968836/limited-reliability-of-radiographic-assessment-of-spinal-progression-in-ankylosing-spondylitis
#3
Sibel Zehra Aydin, Esen Kasapoglu Gunal, Esra Kurum, Servet Akar, Halit Eyyup Mungan, Fatma Alibaz-Oner, Robert G Lambert, Pamir Atagunduz, Helena Marzo Ortega, Dennis McGonagle, Walter P Maksymowych
Objectives: Conventional radiography is key to assessing AS-related spinal involvement and has become increasingly important given that spinal fusion may continue under biologic therapy. We aimed to compare the reliability of radiographic scoring of the spine by using different approaches to understand how different readers agree on overall scores and on individual findings. Method: Six investigators scored 68 plain radiographs of the cervical and lumbar spine of 34 patients with a 2-year interval, for erosions, sclerosis, squaring, syndesmophytes and ankyloses using the Spondyloarthritis Radiography (SPAR) module...
September 15, 2017: Rheumatology
https://www.readbyqxmd.com/read/28944904/triptolide-inhibits-proliferation-differentiation-and-induces-apoptosis-of-osteoblastic-mc3t3%C3%A2-e1-cells
#4
Wei Ji, Shijia Liu, Xia Zhao, Yunke Guo, Sha Xia, Yueyang Lu, Menyun Yin, Xiao Xu
Ankylosing spondylitis (AS) is characterized by the formation of bony spurs. Treatment of the resulting ankylosis, excessive bone formation and associated functional impairment, remain the primary therapeutic aims in research regarding this condition. Triptolide is the primary active component of the perennial vine Tripterygium wilfordii Hook. f., and has previously been demonstrated to exert anti‑tumor activities including inhibition of cell growth and the induction of apoptosis, however, the effect of triptolide on osteoblasts remains to be elucidated...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28879048/no-evidence-for-a-direct-role-of-hla-b27-in-pathological-bone-formation-in-axial-spa
#5
Barbara Neerinckx, Simon Kollnberger, Jacqueline Shaw, Rik Lories
OBJECTIVE: The strong genetic association between HLA-B27 and ankylosing spondylitis has been known for over 40 years. HLA-B27 positivity is possibly associated with severity of ankylosis. We studied the in vitro and in vivo impact of HLA-B27 in models of chondrogenesis and osteogenesis. METHODS: Different in vitro differentiation systems were used to mimic endochondral and direct bone formation. ATDC5 cells and primary human periosteum-derived cells (hPDCs) were transduced with lentiviral vectors expressing HLA-B27 or HLA-B7...
2017: RMD Open
https://www.readbyqxmd.com/read/28810926/the-association-between-sonographic-enthesitis-and-radiographic-damage-in-psoriatic-arthritis
#6
Ari Polachek, Richard Cook, Vinod Chandran, Dafna D Gladman, Lihi Eder
BACKGROUND: To examine the association between sonographic enthesitis and the severity of radiographic features of damage in the peripheral and axial joints in psoriatic arthritis (PsA). METHODS: A cross-sectional analysis was conducted in patients with PsA. The MAdrid Sonography Enthesitis Index (MASEI) scoring system was used to quantify the extent of sonographic entheseal abnormalities. Radiographic damage in the peripheral joints and spine was assessed by the modified Steinbrocker score (mSS), Modified New York Criteria for sacroiliitis, and the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS)...
August 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28743287/genome-wide-dna-methylation-profile-analysis-identifies-differentially-methylated-loci-associated-with-ankylosis-spondylitis
#7
Jiangcan Hao, Yang Liu, Jiawen Xu, Wenyu Wang, Yan Wen, Awen He, Qianrui Fan, Xiong Guo, Feng Zhang
BACKGROUND: Ankylosing spondylitis (AS) is a chronic rheumatic and autoimmune disease. Little is known about the potential role of DNA methylation in the pathogenesis of AS. This study was undertaken to explore the potential role of DNA methylation in the genetic mechanism of AS. METHODS: In this study, we compared the genome-wide DNA methylation profiles of peripheral blood mononuclear cells (PBMCs) between five AS patients and five healthy subjects, using the Illumina Infinium HumanMethylation450 BeadChip...
July 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28732137/prevalence-of-sacroiliitis-in-inflammatory-bowel-disease-using-a-standardized-ct-scoring-system
#8
Jonathan Chan, Ismail Sari, David Salonen, Mark S Silverberg, Nigil Haroon, Robert D Inman
OBJECTIVES: There is an increasing emphasis on early identification and treatment of ankylosing spondylitis (AS) of which the hallmark is sacroiliitis. Patients with inflammatory bowel disease (IBD) are at increased risk of AS and often receive CT scans of their abdomen affording clinicians the opportunity to determine the presence of sacroiliitis. Previous studies using CT have relied only on radiologist's gestalt or a non-validated adaptation of the mNY criteria. Our aim is to assess the prevalence of sacroiliitis in IBD using a validated screening tool and to determine how frequently these patients are referred for rheumatologic evaluation...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28682112/etanercept-for-treating-axial-spondyloarthritis
#9
Xavier Guillot, Clément Prati, Maxime Sondag, Daniel Wendling
Axial spondyloarthritis is an inflammatory rheumatic disease causing back pain, functional impairment and potential ankylosis in the advanced stage. In this context, TNF blockers have been a major therapeutic advance. Etanercept is a soluble recombinant TNF receptor fusion protein in this vain. Areas covered: The aim of this review is to summarize the current published data concerning the efficacy and tolerance of etanercept in axial spondyloarthrits. The authors performed a systematic review on PubMed, using 'etanercept' and 'spondyloarthritis', 'axial spondyloarthritis' or 'ankylosing spondylitis' keywords...
September 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28681364/treatment-of-a-case-of-ulcerative-colitis-with-sacroiliitis-using-granulocyte-and-monocyte-adsorption-apheresis
#10
Hitoshi Ichikawa, Jin Imai, Hajime Mizukami, Takayuki Shirai, Norihito Watanabe
In Japan, sacroiliitis is a very rare extraintestinal manifestation in patients with ulcerative colitis (UC), and it typically presents with intestinal symptoms. Radiography is used for diagnosis, and reveals erosions, sclerosis, and ankylosis, but magnetic resonance imaging is more useful for early detection. The treatment of spondyloarthropathy such as sacroiliitis and spondylitis includes physiotherapy, nonsteroidal anti-inflammatory drugs, sulfasalazine, and immunomodulators. In patients intolerant or cases refractory to these treatments, anti-tumor necrosis factor agents are recommended...
July 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/28589411/accelerated-osteogenic-differentiation-of-human-bone-derived-cells-in-ankylosing-spondylitis
#11
Sungsin Jo, Suman Kang, Jinil Han, Seung Hyun Choi, Ye-Soo Park, Il-Hoon Sung, Tae-Hwan Kim
Ankylosing spondylitis (AS) is characterized by excessive bone formation with syndesmophytes, leading to bony ankylosis. The contribution of osteoblasts to the pathogenesis of ankylosis is poorly understood. The aim of this study was to determine molecular differences between disease controls (Ct) and AS bone-derived cells (BdCs) during osteogenic differentiation with or without inflammation using AS patient serum. We confirmed osteoblastic differentiation of Ct and AS BdCs under osteogenic medium by observing morphological changes and measuring osteoblastic differentiation markers...
June 6, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28558827/early-anti-inflammatory-intervention-ameliorates-axial-disease-in-the-proteoglycan-induced-spondylitis-mouse-model-of-ankylosing-spondylitis
#12
Hsu-Wen Tseng, Tibor T Glant, Matthew A Brown, Tony J Kenna, Gethin P Thomas, Allison R Pettit
BACKGROUND: Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversial, fuelled by the unclear efficacy of anti-inflammatory treatments on radiographic progression. In proteoglycan-induced spondylitis (PGISp), a mouse model of AS, inflammation is the prerequisite for osteoproliferation as osteoproliferation was only observed following inflammation-driven intervertebral disc (IVD) destruction...
May 30, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28469937/fat-metaplasia-on-mri-of-the-sacroiliac-joints-increases-the-propensity-for-disease-progression-in-the-spine-of-patients-with-spondyloarthritis
#13
W P Maksymowych, S Wichuk, P Chiowchanwisawakit, R G Lambert, S J Pedersen
OBJECTIVE: We tested the hypothesis that fat metaplasia on MRI of the sacroiliac joints (SIJ) increases the propensity for new bone formation in the spine of patients with spondyloarthritis. METHODS: We assessed baseline T1-weighted and short τ inversion recovery SIJ MRIs from patients in the Follow Up Research Cohort in Ankylosing Spondylitis (FORCAST). Radiographic progression was assessed using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Structural and inflammatory lesions were scored using the Spondyloarthritis Research Consortium of Canada (SPARCC) SIJ structural and SPARCC SIJ inflammation scores, respectively...
2017: RMD Open
https://www.readbyqxmd.com/read/28361330/the-paradox-of-bone-formation-and-bone-loss-in-ankylosing-spondylitis-evolving-new-concepts-of-bone-formation-and-future-trends-in-management
#14
REVIEW
Marina N Magrey, Muhammad A Khan
PURPOSE OF REVIEW: The purpose of the study is to briefly review the molecular mechanisms that leads to structural damage in ankylosing spondylitis (AS), defined as new bone formation resulting in complete or incomplete ankylosis of the spine, and the impact of treatment with biologics to retard this process. RECENT FINDINGS: The understanding of molecular mechanisms leading to new bone formation in AS has significantly improved but is still incomplete. Availability of biologics has greatly enhanced the treatment of patients with AS, but its impact on slowing the structural damage is still a matter of debate, although a few observational studies have shown that long term use of TNF-α blockers may slow radiographic progression...
April 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28217617/temporomandibular-joint-ankylosis-in-ankylosing-spondylitis-a-case-report-and-review-of-literature
#15
Nishtha Gupta, Nikhil Gupta, Laxmikant Ramkumarsingh Tomar, Nikhil Nair
Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder. It primarily affects the axial skeleton through involvement of the peripheral joint scan occurs. Temporomandibular joint (TMJ) involvement in AS varies from 4% to 35%. Here, we present a case of a 35-year-old male, follow-up of AS from last 8 years on nonsteroidal anti-inflammatory drugs, presented with fresh complaints of painfully restricted movements of jaw during swallowing. Computer tomography of patient demonstrates articular cartilage changes with disc and joint abnormalities...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28125786/ct-abnormalities-in-the-sacroiliac-joints-of-patients-with-diffuse-idiopathic-skeletal-hyperostosis
#16
Naama Leibushor, Einat Slonimsky, Dvora Aharoni, Merav Lidar, Iris Eshed
OBJECTIVE: The purpose of this study is to characterize sacroiliac joints (SIJs) findings at CT of patients with diffuse idiopathic skeletal hyperostosis (DISH), a condition characterized (using the Resnick classification criteria) by ossification of at least four contiguous vertebrae in the thoracic spine and preserved disk space, but without radiographic evidence of intraarticular SIJ abnormalities. MATERIALS AND METHODS: Pelvic CT examinations of 104 patients with DISH (fulfilling the Resnick criteria on spinal CT) and 106 age- and sex-matched control subjects whose entire spine lacked CT evidence of DISH (total, 149 men and 61 women; mean [± SD] age, 72...
April 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28124744/-inflammatory-spinal-diseases-axial-spondyloarthritis-central-importance-of-imaging
#17
REVIEW
X Baraliakos, M Fruth, U Kiltz, J Braun
The diagnosis of axial spondyloarthritis (axSpA) includes classical ankylosing spondylitis (AS) as well as earlier stages and abortive courses of the disease, in which structural alterations have not yet occurred. These are classified as non-radiographic axSpA (nr-axSpa). Inflammatory changes in the entire axial skeleton are characteristic for axSpA and can be visualized by magnetic resonance imaging (MRI), while in most patients structural alterations, such as new bone formation with syndesmophytes and ankylosis develop in the later course of the disease...
March 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28040243/radiographic-damage-and-progression-of-the-cervical-spine-in-ankylosing-spondylitis-patients-treated-with-tnf-%C3%AE-inhibitors-facet-joints-vs-vertebral-bodies
#18
Fiona Maas, Anneke Spoorenberg, Elisabeth Brouwer, Eveline van der Veer, Hendrika Bootsma, Reinhard Bos, Freke R Wink, Suzanne Arends
OBJECTIVES: To investigate radiographic damage and 4-year progression of the cervical facet joints in a prospective observational cohort of AS patients treated with TNF-α inhibitors, to compare this with damage and progression of the cervical vertebral bodies, and to study the relation with patient characteristics and clinical outcome. METHODS: Patients from the Groningen Leeuwarden AS (GLAS) cohort starting TNF-α inhibitors with baseline and 4-year radiographs were included...
April 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27913376/axial-disease-in-psoriatic-arthritis-study-defining-the-clinical-and-radiographic-phenotype-of-psoriatic-spondyloarthritis
#19
COMPARATIVE STUDY
Deepak R Jadon, Raj Sengupta, Alison Nightingale, Mark Lindsay, Eleanor Korendowych, Graham Robinson, Amelia Jobling, Gavin Shaddick, Jing Bi, Robert Winchester, Jon T Giles, Neil J McHugh
OBJECTIVES: To compare the prevalence, clinical and radiographic characteristics of psoriatic spondyloarthritis (PsSpA) in psoriatic arthritis (PsA), with ankylosing spondylitis (AS). METHODS: A prospective single-centre cross-sectional observational study recruited consecutive PsA and AS cases. Participants completed outcome measures, and underwent clinical examination, axial radiographic scoring and HLA-sequencing. Multivariable analyses are presented. RESULTS: The 402 enrolled cases (201 PsA, 201 AS; fulfilling classification criteria for respective conditions) were reclassified based upon radiographic axial disease and psoriasis, as: 118 PsSpA, 127 peripheral-only PsA (pPsA), and 157 AS without psoriasis (AS) cases...
April 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27900509/conversion-of-hip-fusion-to-total-hip-arthroplasty-clinical-radiological-outcomes-and-complications-in-40-hips
#20
Mustafa Celiktas, Ozkan Kose, Adil Turan, Ferhat Guler, Cagri Ors, Emre Togrul
OBJECTIVE: The purpose of this retrospective study is to report the clinical and radiological outcome of total hip arthroplasty in patients with previous hip arthrodesis. PATIENTS AND METHODS: We retrospectively reviewed 28 (40 hips) prospectively followed patients in whom ankylosed hips were converted to total hip arthroplasty (THA) between 2010 and 2014 in our institution. The average age at the time of the conversion operation was 40.8 ± 9.8 years (range 24-62)...
January 2017: Archives of Orthopaedic and Trauma Surgery
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