Read by QxMD icon Read

Ankylosis spondylitis

Xenofon Baraliakos, Juergen Braun
Inflammatory and chronic structural changes are objective signs of axial spondyloarthritis. In the sacroiliac joints (SIJs), inflammation (sacroiliitis) can be visualized as bone marrow edema, whereas chronic structural changes are visualized as fat metaplasia, erosions, sclerosis, or ankylosis in the area of the SIJ. In the spine, bone marrow edema in the vertebral bodies represents spondylitis but can also affect the facet and the costovertebral and costotransverse joints (arthritis), whereas structural changes are visualized as fat metaplasia, sclerosis or syndesmophytes and ankylosis at the vertebral edges...
November 2016: Rheumatic Diseases Clinics of North America
Dong-Xu Feng, Kun Zhang, Yu-Min Zhang, Yue-Wen Nian, Jun Zhang, Xiao-Min Kang, Shu-Fang Wu, Yang-Jun Zhu
OBJECTIVES: Total hip arthroplasty is a reliable therapeutic intervention in patients with ankylosing spondylitis, in whom the aims of surgery are to reduce pain, restore hip function and improve quality of life. The current study is a retrospective analysis of the clinical and radiographic findings in a consecutive series of patients with hip ankylosis associated with severe ankylosing spondylitis who underwent bilateral primary total hip arthroplasty using non-cemented components. METHODS: From June 2008 to May 2012, total hip arthroplasty was performed on 34 hips in 17 patients with bilateral ankylosis caused by ankylosing spondylitis...
August 2016: Orthopaedic Surgery
Yavuz Saglam, Irfan Ozturk, Mehmet Fevzi Cakmak, Mustafa Ozdemir, Onder Yazicioglu
INTRODUCTION: The aim of this study was to evaluate the clinical and radiological outcomes of total hip arthroplasty (THA) in patients with Ankylosing Spondylitis (AS). PATIENTS AND METHODS: One hundred five hips of 61 AS patients (mean age: 41.3 ± 10.2 years) who underwent THA between 1997 and 2012 were included into the study. Dorr's classification of proximal femoral geometry, acetabular protrusio, bone ankylosis, acetabular protrusion, Brooker classification of heterotopic ossification (HO), Gruen and Charnley classifications of implant loosening were used in radiographic assessments...
August 2016: Acta Orthopaedica et Traumatologica Turcica
Jong Ki Shin, Jung Sub Lee, Sung Shik Kang, Jae Myung Lee, Bu Hyun Youn
STUDY DESIGN: Prospective study. OBJECTIVE: To test the inter- and intra-observer reliabilities of five specific measures of global cervical sagittal alignment in patients with ankylosing spondylitis (AS), and to suggest a better means of measuring cervical sagittal alignment. SUMMARY OF BACKGROUND DATA: The intraobserver and interobserver reliabilities of several different methods of measuring cervical lordosis have been reported. However, they have not been studied till yet in patients with AS...
June 3, 2016: Clinical Spine Surgery
Kai Song, Xiaojing Su, Yonggang Zhang, Chao Liu, Xiangyu Tang, Guoying Zhang, Guoquan Zheng, Geng Cui, Xuesong Zhang, Keya Mao, Zheng Wang, Yan Wang
PURPOSE: Chin-brow vertical angle (CBVA) is very important in correction of thoracolumbar kyphotic deformity in ankylosing spondylitis (AS), especially for the patients with cervical ankylosis. In previous study, Suk et al. stated that the patients with CBVA between -10° and 10° had better horizontal gaze. Unfortunately, in our clinical practice, we found the patients with CBVA between -10° and 10° after surgery usually complained of difficulty in cooking, cleaning, desk working and the like, although they had excellent horizontal gaze...
August 2016: European Spine Journal
Janine Bleil, Rene Maier, Axel Hempfing, Joachim Sieper, Heiner Appel, Uta Syrbe
OBJECTIVE: We previously suggested that fibroblast-rich granulation tissue eroding the subchondral bone is instrumental in the joint remodeling that occurs in ankylosing spondylitis (AS). The purpose of this study was to determine if this granulation tissue also carries bone-forming capabilities, which we approached by searching for bone-forming cells (hypertrophic chondrocytes, osteoblasts) in its vicinity. We also assessed adipogenic tissue transformation, which has been suggested to be an intermediate feature in AS bone formation based on imaging studies...
October 2016: Arthritis & Rheumatology
Zheng Li, Sunny H Wong, Jianxiong Shen, Matthew T V Chan, William Ka Kei Wu
Ankylosing spondylitis (AS) is a common and genetically heterozygous inflammatory rheumatic disease characterized by new bone formation, ankylosis and inflammation of hip, sacroiliac joints and spine. Until now, there is no method for early diagnosis of AS and the effective treatment available for AS patients remain largely undefined.We searched articles indexed in PubMed (MEDLINE) database using Medical Subject Heading (MeSH) or Title/Abstract words ("microRNA" and "ankylosing spondylitis") from inception up to November 2015...
April 2016: Medicine (Baltimore)
Jia Li, Jinzhu Zhao, Chongru He, Wenwen Tong, Yuming Zou, Weidong Xu
BACKGROUND: This study was conducted to compare the blood loss during primary total hip arthroplasty (THA) between ankylosing spondylitis (AS) and hip osteoarthritis (OA). METHODS: We reviewed 120 THAs in 68 patients comprising 3 groups: AS with total bony ankylosis of the hips (ASB), AS with stiff hips (ASS), and OA. Demographics, perioperative laboratory values, intraoperative data, blood loss, transfusion rate, transfusion reactions, surgical complications, hospitalization cost, and length of stay (LOS) were collected and analyzed among ASB, ASS, and OA groups...
July 2016: Journal of Arthroplasty
Lovro Lamot, Mandica Vidović, Marija Perica, Lana Tambić Bukovac, Miroslav Harjacek
Spondyloarthritis or spondyloarthropathy (SpA) is a multifactorial disease in which a disturbed interplay occurs between the immune system and environmental factors on a predisposing genetic background, which leads to inflammation and structural damage of target tissue. Many recent researches on development of SpA showed important role of innate and adaptive immunity as well as of prominent bone tissue remodeling which leads to osteoproliferation and ankylosis. It is believed that possible sites of inflammation in SpA are entheses, sinovium and gut...
2015: Reumatizam
Maria A C van der Weijden, J Christiaan van Denderen, Willem F Lems, Michael T Nurmohamed, Ben A C Dijkmans, Irene E van der Horst-Bruinsma
OBJECTIVE: Ankylosing spondylitis (AS) is characterized by chronic inflammation leading to ankylosis, but also to low bone mineral density (BMD) and vertebral fractures (VFx). Treatment with tumor necrosis factor-α blockers decreases inflammation and has shown to be effective in increasing BMD. We studied the effects of etanercept (ETN) on BMD and VFx in patients with AS after 2 years of treatment. Further, we studied changes in bone turnover markers and radiological damage. METHODS: Patients with active AS, treated with ETN for 2 years, were included...
April 2016: Journal of Rheumatology
Hsu-Wen Tseng, Miranda E Pitt, Tibor T Glant, Allan F McRae, Tony J Kenna, Matthew A Brown, Allison R Pettit, Gethin P Thomas
BACKGROUND: Ankylosing spondylitis (AS) is an immune-mediated arthritis particularly targeting the spine and pelvis and is characterised by inflammation, osteoproliferation and frequently ankylosis. Current treatments that predominately target inflammatory pathways have disappointing efficacy in slowing disease progression. Thus, a better understanding of the causal association and pathological progression from inflammation to bone formation, particularly whether inflammation directly initiates osteoproliferation, is required...
2016: Arthritis Research & Therapy
Ke Li, Qingmeng Zhang, Heng Li, Rui Li, Chi Xu, Jiying Chen
OBJECTIVE: To evaluate the inflammatory markers in patients with ankylosing spondylitis (AS) or non-inflammatory diseases undergoing total hip arthroplasty (THA) and to ascertain the variation trend of perioperative inflammatory markers and the influence of inflammation markers after THA. METHODS: Between January 2013 and December 2014, 153 consecutive patients with AS were included. According to the range of motion (ROM), the patients were divided into ankylosis group (ROM: 0 degrees; group A, n = 92) and stiff group (ROM: 3-46 degrees; group B, n = 61); 120 non-inflammatory diseases patients having no bacterial infection and undergoing primary THA served as non-inflammatory group (group C)...
October 2015: Chinese Journal of Reparative and Reconstructive Surgery
Neeraj Patni, Abhidha Shah, Vithal Rangarajan, Atul Goel
Patients with ankylosing spondylitis (AS) are at an increased risk of spinal fractures due to the altered spinal biomechanics. Moreover, it is difficult to treat these fractures due to the combination of ankylosis and osteoporosis. We report successful management of a C6-C7 vertebral fracture in a patient with AS. The patient improved in his neurological status and a good fusion was seen at a follow-up of 24 months.
October 2015: Journal of Craniovertebral Junction and Spine
Bon San Koo, Yoonah Song, Kyung Bin Joo, Seunghun Lee, Tae-Hwan Kim
OBJECTIVE: We aimed to evaluate the involvement of the symphysis pubis in patients with ankylosing spondylitis (AS), and to assess the correlations between symphysis pubis changes and clinical findings. METHODS: We retrospectively evaluated a total of 222 male patients with AS who underwent pelvic and cervical/lumbar spine radiography at the Hanyang University Hospital for Rheumatic Diseases from August 2004 to February 2014. Radiographs were examined by 2 experienced radiologists, and radiographic damage was scored as follows: 0 (no damage), 1 (subtle irregularity and/or subchondral sclerosis), 2 (erosion), 3 (partial ankylosis), and 4 (total ankylosis)...
February 2016: Journal of Rheumatology
Bettina G Weiss, Lucas M Bachmann, Christian W A Pfirrmann, Rudolf O Kissling, Veronika Zubler
OBJECTIVE: Discrimination of diffuse idiopathic skeletal hyperostosis (DISH) and ankylosing spondylitis (AS) can be challenging. Usefulness of whole-body magnetic resonance imaging (WB-MRI) in diagnosing spondyloarthritis has been recently proved. We assessed the value of clinical variables alone and in combination with WB-MRI to distinguish between DISH and AS. METHODS: Diagnostic case-control study: 33 patients with AS and 15 patients with DISH were included. All patients underwent 1...
February 2016: Journal of Rheumatology
Eun-Ju Lee, Eun-Jin Lee, Yeon-Ho Chung, Da-Hyun Song, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Tae-Hwan Kim, Ye-Soo Park, Soo-Hyun Kim, Eun-Ju Chang, Yong-Gil Kim
BACKGOUND: The formation of bony spurs and ankylosis is a key pathognomic feature in ankylosing spondylitis (AS) and results in functional impairment. The aim of this study was to investigate the role of IL-32γ in osteoblast (OB) differentiation and its association with the pathogenesis of AS. METHODS: The concentration and expression of IL-32γ were evaluated in synovial fluid and tissue from patients with AS, rheumatoid arthritis (RA) and osteoarthritis (OA), using enzyme-linked immunosorbent assay and immunohistochemistry...
2015: Arthritis Research & Therapy
Wanqing Xie, Lijiang Zhou, Shan Li, Tianqian Hui, Di Chen
Spondyloarthritis (SpA) is a group of diseases consisting of psoriatic arthritis (PsA), reactive arthritis, arthritis related to inflammatory bowel disease (a subgroup of juvenile idiopathic arthritis), and ankylosing spondylitis (the prototype of SpA). Axial bone formation and the combination of concurrent erosion and new bone formation are specific characteristics of SpA disease. The use of antiproinflammatory cytokines, such as inhibitors of tumor necrosis factor α (TNF-α), appears to be the greatest advance in the treatment of SpA over the past 20 years...
January 2016: Annals of the New York Academy of Sciences
S E Putnis, G K Wartemberg, W S Khan, S Agarwal
Ankylosing spondylitis is a spondyloarthropathy affecting the sacro-iliac joints with subsequent progression to the spine and the hip joints. The hip joints are affected by synovitis, enthesial inflammation, involvement of medullary bone, progressive degeneration and secondary osteoarthritis. Clinical presentation is usually in the form of pain and stiffness progressing to disabling fixed flexion contractures and in some instances, complete ankylosis. Hip arthroplasty should be considered for hip pain, postural and functional disability, or pain in adjacent joints due to hip stiffness...
2015: Open Orthopaedics Journal
Jeong-Won Lee, Ji-Hyoun Kang, Yi-Rang Yim, Ji-Eun Kim, Lihui Wen, Kyung-Eun Lee, Dong-Jin Park, Tae-Jong Kim, Yong-Wook Park, Shin-Seok Lee
The aim of this study was to investigate the potential predictors of switching tumor necrosis factor (TNF)-α inhibitors in Korean patients with ankylosing spondylitis (AS). The patients who had been treated with TNF-α inhibitors were divided into two groups depending on whether they had switched TNF-α inhibitors. Demographic, clinical, laboratory, and treatment data at the time of initiation of TNF-α inhibitor treatment were compared between switchers and non-switchers, and within switchers according to the reasons for switching...
2015: PloS One
Christian Buchbender, Benedikt Ostendorf, Verena Ruhlmann, Philipp Heusch, Falk Miese, Karsten Beiderwellen, Matthias Schneider, Juergen Braun, Gerald Antoch, Xenofon Baraliakos
OBJECTIVE: The biologically active molecule used in positron emission tomography (PET) for depiction of osteoblastic activity is 18F-labeled fluoride (18F-F). We examined whether inflammatory or chronic changes on magnetic resonance imaging (MRI) in the sacroiliac joints (SIJ) and the spines of patients with active ankylosing spondylitis (AS) are linked to osteoblastic activity, assessed by PET/MRI. METHODS: Thirteen patients with AS (mean age 37.8 ± 11.4 yrs, Bath AS Disease Activity Index > 4, no anti-TNF treatment) underwent 3-Tesla whole-spine and SIJ PET/MRI...
September 2015: Journal of Rheumatology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"