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Pyelonephritis

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https://www.readbyqxmd.com/read/28717547/emphysematous-pyelonephritis-changing-trend-of-clinical-spectrum-pathogenesis-management-and-outcome
#1
Ashok Kumar Sokhal, Manoj Kumar, Bimalesh Purkait, Ankur Jhanwar, Kawaljit Singh, Ankur Bansal, Satyanarayan Sankhwar
OBJECTIVE: To highlight changing trend of clinical spectrum, comparing management options and predictors of outcome of emphysematous pyelonephritis. MATERIAL AND METHODS: This study included patients who were diagnosed as emphysematous pyelonephritis between August, 2001 to July, 2015. We excluded other possible causes of gas in renal system. Baseline patient characteristics, clinical spectrum, serum and urinary biochemical parameters, radiological findings, management and outcomes were recorded...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28716390/impact-of-cytokine-genetic-polymorphisms-on-the-risk-of-renal-parenchymal-infection-in-children
#2
Almontaser Hussein, Eman Askar, Ahlam Badawy, Khaled Saad, Asmaa Zahran, Ahmad A Elderwy
BACKGROUND: Acute pyelonephritis is associated with renal scarring in up to 30% of patients. Renal scarring may cause significant long-term morbidity. The pathogenesis of acute pyelonephritis remains unclear, although it involves interaction among uroepithelium, the immune system cells, and the locally produced cytokines. That some UTI-prone children develop acute pyelonephritis, and eventually renal parenchymal scarring, suggests a genetic role. Interleukin-6, interleukin-8, chemokine receptor-1 (CXCR1), and tumor necrosis factor-alpha (TNFα), the key regulators of the host immune responses, are proteins whose secretion is controlled by genes...
July 3, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28716317/long-term-complications-of-the-neurogenic-bladder
#3
REVIEW
Unwanaobong Nseyo, Yahir Santiago-Lastra
It is widely accepted that neurogenic lower urinary tract dysfunction, when left untreated, has a natural history that has a potential for causing deterioration of renal function over time. However, certain patient profiles are at risk for this and other complications. This can be linked to their underlying neurologic disease process. Identifying risk profiles allows the provider to determine what surveillance strategies might be adopted. Risk factors for upper urinary tract deterioration include loss of bladder compliance, repeated bouts of pyelonephritis, and chronic indwelling catheterization...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28711547/interobserver-variability-for-interpretation-of-dmsa-scans-in-the-rivur-trial
#4
Tej K Mattoo, Steven J Skoog, Lisa Gravens-Mueller, Russell W Chesney, Alejandro Hoberman, Ranjiv Mathews, Marva Moxey-Mims, Anastasia Ivanova, Saul P Greenfield, Myra A Carpenter
INTRODUCTION: Technetium-99m dimercaptosuccinic acid (DMSA) renal scans are used in the diagnosis of renal scarring. In the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial that randomized 607 children, DMSA renal scans were used for evaluating the presence and the severity of renal scarring. OBJECTIVE: The aim was to determine interobserver variability in reporting of DMSA renal scans in the RIVUR trial. STUDY DESIGN: We compared DMSA renal scan reports for renal scarring and acute pyelonephritis from all non-reference local radiologists (ALRs) at study sites with adjudicated as well as non-adjudicated reports from two reference radiologists (RRs) of the RIVUR trial...
June 1, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28711077/acute-kidney-injury-in-pregnancy
#5
Belinda Jim, Vesna D Garovic
Pregnancy-related acute kidney injury (AKI) has declined in incidence in the last three decades, although it remains an important cause of maternal and fetal morbidity and mortality. Pregnancy-related causes of AKI such as preeclampsia, acute fatty liver of pregnancy, HELLP (Hemolysis, Elevated Liver function tests, Low Platelets) syndrome, and the thrombotic microangiopathies (thrombotic thrombocytopenic purpura, atypical hemolytic-uremic syndrome [HUS]) exhibit overlapping features and often present as diagnostic dilemmas...
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28710643/-vesicoureteral-reflux-watchful-waiting-surgery-or-antibiotic-prophylaxis
#6
REVIEW
A Schröder
Primary vesicoureteral reflux (VUR) is a dynamic disease with several factors influencing its course. Therapeutic options range from watchful waiting to open surgery. Multiple risk factors for the development of pyelonephritis are identified, which then determine the decision for the appropriate treatment option. They include age, gender, history of pyelonephritis and renal scarring, bladder and bowel dysfunction (BBD), circumcision status and parental preference. The use of continuous antibiotic prophylaxis (CAP) is becoming increasingly controversial with antibiotic resistance being a major concern...
July 14, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28709609/adenovirus-pyelonephritis-in-the-late-posttransplant-period
#7
Gyl Eanes Barros Silva, Valdair Francisco Muglia, Natalino Salgado Filho, Eduardo Medeiros de Araújo, Joyce Santos Lages, Teresa Cristina Alves Ferreira, Roberto Silva Costa, Márcio Dantas
No abstract text is available yet for this article.
August 2017: Kidney International
https://www.readbyqxmd.com/read/28701203/discovery-of-a-novel-dominant-mutation-in-the-ren-gene-after-forty-years-of-renal-disease-a-case-report
#8
Rhian L Clissold, Helen C Clarke, Olivera Spasic-Boskovic, Kim Brugger, Stephen Abbs, Coralie Bingham, Charles Shaw-Smith
BACKGROUND: Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been described in the published literature to date. We report a novel dominant REN mutation discovered in an individual after forty years of renal disease. CASE PRESENTATION: A 57 year old Caucasian woman with chronic kidney disease stage five was reviewed in a regional joint renal genetics clinic...
July 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28697495/electrolyte-and-acid-base-abnormalities-in-infants-with-community-acquired-acute-pyelonephritis-prospective-cross-sectional-study
#9
Gregorio P Milani, Angela Grava, Mario G Bianchetti, Sebastiano A G Lava, Laura Dell'Era, Thomas Teatini, Emilio F Fossali
BACKGROUND: Retrospective case series suggest that abnormalities in fluid, electrolyte, and acid-base homeostasis may occur among infants with a febrile urinary tract infection. Potentially inaccurate laboratory methods of sodium testing have often been used. METHODS: Between January 2009 and June 2016, we managed 80 previously healthy infants (52 males and 28 females) ≥4 weeks to ≤24 months of age with their first episode of acute pyelonephritis. Ionized sodium, ionized potassium and ionized chloride were determined by direct potentiometry, as recommended by the International Federation of Clinical Chemistry...
July 12, 2017: Nephron
https://www.readbyqxmd.com/read/28695238/predictive-risk-factors-for-systemic-inflammatory-response-syndrome-following-ureteroscopic-laser-lithotripsy
#10
Yusuke Uchida, Ryoji Takazawa, Sachi Kitayama, Toshihiko Tsujii
The objective of this study was to investigate risk factors for the development of systemic inflammatory response syndrome following ureteroscopic laser lithotripsy. We retrospectively collected data of 469 patients who underwent ureteroscopic laser lithotripsy at our single institution from February 2008 to June 2016. Details for the patient, the stone, and the surgical factors that potentially contributed to postoperative infection were extracted. Using a logistic regression model, we analyzed how the clinical factors affected the incidence of systemic inflammatory response syndrome...
July 10, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28694560/peritransplant-soluble-cd30-as-a-risk-factor-for-slow-kidney-allograft-function-early-acute-rejection-worse-long-term-allograft-function-and-patients-survival
#11
Andriy V Trailin, Tetyana I Ostapenko, Tamara N Nykonenko, Svitlana N Nesterenko, Olexandr S Nykonenko
BACKGROUND: We aimed to determine whether serum soluble CD30 (sCD30) could identify recipients at high risk for unfavorable early and late kidney transplant outcomes. METHODS: Serum sCD30 was measured on the day of kidney transplantation and on the 4th day posttransplant. We assessed the value of these measurements in predicting delayed graft function, slow graft function (SGF), acute rejection (AR), pyelonephritis, decline of allograft function after 6 months, and graft and patient survival during 5 years of follow-up in 45 recipients...
2017: Disease Markers
https://www.readbyqxmd.com/read/28694079/distal-ureteral-diameter-ratio-is-predictive-of-breakthrough-febrile-urinary-tract-infection
#12
Angela M Arlen, Traci Leong, Paul J Guidos, Siobhan E Alexander, Christopher S Cooper
PURPOSE: Distal ureteral diameter ratio (UDR) is an objective measure that is prognostic of spontaneous vesicoureteral reflux (VUR) resolution. Along with likelihood of resolution, improved identification of children at risk for recurrent febrile urinary tract infections (fUTI) may impact management decisions. We evaluated the utility of UDR as a predictive factor for breakthrough fUTI. MATERIALS AND METHODS: Children with primary VUR and detailed voiding cystourethrogram (VCUG) were identified...
July 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28683358/distinctive-inflammatory-profile-between-acute-focal-bacterial-nephritis-and-acute-pyelonephritis-in-children
#13
Makoto Mizutani, Shunji Hasegawa, Takeshi Matsushige, Naoki Ohta, Setsuaki Kittaka, Madoka Hoshide, Takeshi Kusuda, Kazumasa Takahashi, Kiyoshi Ichihara, Shouichi Ohga
BACKGROUND: Acute focal bacterial nephritis (AFBN) is a severe form of upper urinary tract infection (UTI) with neurological manifestations and focal renal mass lesions on computed tomography (CT). Prolonged antibiotic therapy may improve the renal outcome, but the early differential diagnosis of AFBN from acute pyelonephritis (APN) is challenging. We searched for effective biomarkers of AFBN based on the pathophysiology of upper UTIs. METHODS: Of 52 upper UTI cases treated at Yamaguchi University between 2009 and 2016, 38 pediatric patients with AFBN (n=17) or APN (n=21) who underwent ultrasonography and/or CT were enrolled...
July 3, 2017: Cytokine
https://www.readbyqxmd.com/read/28665281/experimental-model-for-acute-kidney-injury-caused-by-uropathogenic-escherichia-coli
#14
Beata Skowron, Agnieszka Baranowska, Jolanta Kaszuba-Zwoińska, Grażyna Więcek, Anna Malska-Woźniak, Piotr Heczko, Magdalena Strus
INTRODUCTION: Acute kidney injury (AKI) is the rapid deterioration of renal function, diagnosed on the basis of an increase in serum creatinine and abnormal urinary parameters. AKI is associated with increased risk of mortality or chronic kidney disease (CKD). The aim of the study was to develop an experimental model for AKI resulting from Escherichia coli-induced pyelonephritis. E. coli was isolated from a patient with clinical symptoms of urinary tract infection (UTI). MATERIAL/METHODS: The study included three groups of female Wistar rats (groups 1, 2 and 3), in which pyelonephritis was induced by transurethral inoculation with highly virulent E...
June 19, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28660334/follow-up-of-acute-pyelonephritis-what-causes-the-diffusion-weighted-magnetic-resonance-imaging-recovery-to-lag-clinical-recovery
#15
Riccardo Faletti, Marco Gatti, Serena Bassano, Daniela Finocchietti, Stefano Fiore, Loredana Colla, Laura Bergamasco, Maria Carla Cassinis, Paolo Fonio
PURPOSE: To analyze with diffusion-weighted magnetic resonance imaging (DW-MRI) the evolution and progress to resolution of acute pyelonephritis (APN) foci over a period of 3 months after onset. METHODS: 30 women (age 22-51 years) with clinical, laboratory (white blood cell and C-reactive protein), and DW-MRI (4b-values 0, 50, 600, 1000 s/mm(2)) diagnosis of APN were prospectively enrolled. Two double-blinded radiologists evaluated the number of APN foci, and for each of them dimension (D), absolute diffusion coefficient (ADC), and its ratio R to the ADC of unaffected parenchyma...
June 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28644363/allergic-interstitial-nephritis-masquerading-as-pyelonephritis-in-a-pediatric-patient-with-crohn-disease
#16
Jason R Lomboy, Folashade Jose
No abstract text is available yet for this article.
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28638940/laparoscopic-vesico-ureteral-reimplantation-with-lich-gregoir-approach-in-children-medium-term-results-of-159-renal-units-in-117-children
#17
Victor Soulier, Aure Lien Scalabre, Manuel Lopez, Chi-Ying Li, Sodara Thach, Sophie Vermersch, Franc Ois Varlet
PURPOSE: Vesico-ureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. Surgery is an important part of its management. Laparoscopic ureteric reimplantation using the Lich-Gregoir technique is an option for VUR. The aim of this study is to assess short- and medium-term outcomes of this approach. MATERIALS AND METHODS: This is a retrospective study including all children with VUR treated by laparoscopic extravesical ureteral reimplantation with the Lich-Gregoir technique in University Hospital of Saint-Etienne from August 2007 to May 2016...
June 21, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28638665/a-rare-case-of-septic-shock-secondary-to-emphysematous-hepatitis
#18
Khaled M Nada, Ibrahim El Husseini, Mohammad E Abu Hishmeh, Neerav S Shah, Nadezhda Ibragimova, Riyad Basir
OBJECTIVE: To describe a case of emphysematous hepatitis which is a rare clinical entity, characterized by a fatal, rapidly progressive infection of the liver with a radiological appearance simulating emphysematous pyelonephritis and to help provide more data about the causative organisms and precipitating factors of this pathology. DATA SOURCES AND SYNTHESIS: Relevant literature was reviewed and, to the best of our knowledge, there is limited data regarding the pathogenesis, causative organisms, and management of this condition...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28638336/emphysematous-pyelonephritis-and-cystitis-unusual-adverse-events-during-concurrent-chemoradiotherapy-for-lung-cancer
#19
Tetsuya Yokoyama, Seiji Shinozaki, Hidenobu Arimura, Keita Nakatomi, Hiroshi Wataya
Various adverse events can occur during antineoplastic therapy. A 67-year-old diabetic woman developed an emphysematous urinary tract infection (UTI) associated with chemoradiotherapy for lung cancer. She had received weekly carboplatin plus paclitaxel with thoracic radiotherapy and developed a fever on day 19. Computed tomography showed a large quantity of gas within the urinary tract. She was therefore diagnosed with emphysematous UTI. Poor diabetes control due to the weekly administration of dexamethasone, an existing urinary tract obstruction, and bone marrow suppression were involved in her serious infection...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28631909/-characterization-of-microbial-flora-in-patients-suspected-of-having-urogenital-tuberculosis
#20
A G Cherednichenko, E V Kulchavenya
INTRODUCTION: In the structure of tuberculosis morbidity, urogenital tuberculosis (UGT) ranks second or third only to pulmonary tuberculosis. Every fourth patient has the stage of cavern formation at first presentation. Seventy five percent of nephrotuberculosis cases co-occur with nonspecific pyelonephritis, which excludes "sterile pyuria". We aimed to determine the microbial spectrum of urine and gonadal appendages in patients with suspected UGT and to investigate the susceptibility of the isolated microorganisms to the main antibacterial drugs...
June 2017: Urologii︠a︡
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