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https://www.readbyqxmd.com/read/28651192/efficient-photocatalytic-degradation-of-toxic-dyes-from-aqueous-environment-using-gelatin-zr-iv-phosphate-nanocomposite-and-its-antimicrobial-activity
#1
Manita Thakur, Gaurav Sharma, Tansir Ahamad, Ayman A Ghfar, Deepak Pathania, Mu Naushad
In the present study, gelatin-Zr(IV) phosphate nanocomposite (GT/ZPNC) was synthesized by sol-gel method by mixing the gelatin gel into the inorganic part Zr (IV) phosphate (ZP). The GT/ZPNC was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy (SEM), transmission electron micron scope (TEM), X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The photodegradation activity of GT/ZPNC was explored for the removal of methylene blue (MB) and fast green (FG) dyes from aqueous solution...
June 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28651154/new-comprehensive-studies-of-a-gold-iii-dithiocarbamate-complex-with-proven-anticancer-properties-aqueous-dissolution-with-cyclodextrins-pharmacokinetics-and-upstream-inhibition-of-the-ubiquitin-proteasome-pathway
#2
Marianna F Tomasello, Chiara Nardon, Valeria Lanza, Giuseppe Di Natale, Nicolò Pettenuzzo, Stefano Salmaso, Danilo Milardi, Paolo Caliceti, Giuseppe Pappalardo, Dolores Fregona
The gold(III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS,kS')-N-methylglycinate] gold(III)), is endowed with promising in vitro/in vivo antitumor activity and toxicological profile. Here, we report our recent strategies to improve its water solubility and stability under physiological conditions along with our efforts for unravelling its tangled mechanism of action. We used three types of α-cyclodextrins (CDs), namely β-CD, Me-β-CD and HP-β-CD to prepare aqueous solutions of AuL12...
June 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28651008/production-and-purification-of-human-hsp90%C3%AE-in-escherichia-coli
#3
Martina Radli, Dmitry B Veprintsev, Stefan G D Rüdiger
The molecular chaperone Hsp90 is an essential member of the cellular proteostasis system. It plays an important role in the stabilisation and activation of a large number of client proteins and is involved in fatal disease processes, e.g. Alzheimer disease, cancer and cystic fibrosis. This makes Hsp90 a crucial protein to study. Mechanistic studies require large amounts of protein but the production and purification of recombinant human Hsp90 in Escherichia coli is challenging and laborious. Here we identified conditions that influence Hsp90 production, and optimised a fast and efficient purification protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28650111/photochromic-dopamine-receptor-ligands-based-on-dithienylethenes-and-fulgides
#4
Daniel Lachmann, Carolin Studte, Barbara Männel, Harald Huebner, Peter Gmeiner, Burkhard König
We describe the incorporation of the well-investigated class of photochromic dithienylethenes (DTEs) and fulgides into known dopamine receptor ligands like 1,4-disubstituted aromatic and hydroxybenzoxazinone piperazines as well as aminoindanes. Subtype and functional selective photochromic ligands were obtained and characterized by NMR and UV-VIS spectroscopic measurements. The photophysical properties of the DTE based dopamine ligands revealed a high fatigue resistance for the diarylmaleimides, but the ringclosure could not be accomplished in polar solvents due to a known twisted intramolecular charge transfer (TICT)...
June 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28650085/immunogenicity-of-plant-produced-african-horse-sickness-virus-like-particles-implications-for-a-novel-vaccine
#5
Susan J Dennis, Ann E Meyers, Alan J Guthrie, Inga I Hitzeroth, Edward P Rybicki
African horse sickness (AHS) is a debilitating and often fatal viral disease affecting horses in much of Africa, caused by the dsRNA orbivirus African horse sickness virus (AHSV). Vaccination remains the single most effective weapon in combatting AHS, as there is no treatment for the disease apart from good animal husbandry. However, the only commercially available vaccine is a live attenuated version of the virus (LAV). The threat of outbreaks of the disease outside its endemic region and the fact that the LAV is not licensed for use elsewhere in the world, have spurred attempts to develop an alternative safer, yet cost-effective recombinant vaccine...
June 26, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28649965/pawflim-reducing-bias-and-uncertainty-to-enable-lower-photon-count-in-flim-experiments
#6
Mauro Silberberg, Hernán E Grecco
Förster resonant energy transfer measured by fluorescence lifetime imaging microscopy (FRET-FLIM) is the method of choice for monitoring the spatio-temporal dynamics of protein interactions in living cells. To obtain an accurate estimate of the molecular fraction of interacting proteins requires a large number of photons, which usually precludes the observation of a fast process, particularly with time correlated single photon counting (TCSPC) based FLIM. In this work, we propose a novel method named pawFLIM (phasor analysis via wavelets) that allows the denoising of FLIM datasets by adaptively and selectively adjusting the desired compromise between spatial and molecular resolution...
June 26, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28648696/integrating-behaviour-into-the-pace-of-life-continuum-divergent-levels-of-activity-and-information-gathering-in-fast-and-slow-living-snakes
#7
Eric J Gangloff, Melinda Chow, Vianey Leos-Barajas, Stephanie Hynes, Brooke Hobbs, Amanda M Sparkman
An animal's life history, physiology, and behaviour can be shaped by selection in a manner that favours strong associations among these aspects of an integrated phenotype. Recent work combining animal personality and life-history theory proposes that animals with faster life-history strategies (i.e., fast growth, high annual reproductive rate, short lifespan) should exhibit higher general activity levels relative to those with slower life-history strategies, but empirical tests of within-species variation in these traits are lacking...
June 22, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28648259/semisynthesis-and-spectral-characterization-of-5-methylpyranopelargonidin-and-4-methylfuropelargonidin-and-their-separation-and-detection-in-strawberry-fruit-wine
#8
Ondřej Kurka, Lukáš Kučera, Helena Pelantová, Marek Kuzma, Vladimír Havlíček, Petr Bednář
Condensation of anthocyanins and their aglycons with small organic molecules yields more stable natural dyes, e.g. pyranoanthocyanins arising spontaneously in various food products. Reaction of pelargonidin with acetone produces two isomeric anthocyanidin dyes - 5-methylpyranopelargonidin and 4-methylfuropelargonidin. A robust semipreparative liquid chromatographic method was developed to isolate both derivatives from a simple aged solution of pelargonidin in methanol: acetone: 37% aqueous hydrochloric acid (1:1:0...
June 17, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28648117/alteration-of-sarcoplasmic-reticulum-ca-2-atpase-expression-in-lower-limb-ischemia-caused-by-atherosclerosis-obliterans
#9
J Fodor, A Gomba-Tóth, T Oláh, E Zádor, Zs Cs Tóth, I Ioannis, B Molnár, I Kovács, L Csernoch
Atherosclerosis is a disease caused by a build-up of fatty plaques and cholesterol in the arteries. The lumen of the vessels is obliterated resulting in restricted blood supply to tissues. In ischemic conditions, the cytosolic Ca(2+) level of skeletal muscle may increase, indicating the alteration of Ca(2+) removal mechanisms. Ca(2+) is transported from cytosol into the sarcoplasmic reticulum by Ca(2+) ATPase (SERCA), with its 1a isoform expressed in adult, while its 1b isoform in neonatal and regenerating fast-twitch skeletal muscle...
June 26, 2017: Physiology International
https://www.readbyqxmd.com/read/28648070/magnetic-resonance-imaging-quantification-of-fasted-state-colonic-liquid-pockets-in-healthy-humans
#10
Kathryn Murray, Caroline L Hoad, Deanna M Mudie, Jeff Wright, Khaled Heissam, Nichola Abrehart, Susan E Pritchard, Salem Al Atwah, Penny A Gowland, Martin C Garnett, Gregory E Amidon, Robin C Spiller, Gordon L Amidon, Luca Marciani
The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT). However, little is known about the time course of GIT liquid volumes after drinking a glass of water (8 oz), particularly in the colon, which is a targeted site for both locally and systemically acting drug products. Previous Magnetic Resonance Imaging (MRI) studies offered novel insights on GIT liquid distribution in fasted humans in the stomach and small intestine, and showed that freely mobile liquid in the intestine collects in fairly distinct regions or 'pockets'...
June 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28647339/the-effects-of-amoxicillin-and-vancomycin-on-parameters-reflecting-cholesterol-metabolism
#11
S Baumgartner, D Reijnders, M C J M Konings, A K Groen, D Lütjohann, G H Goossens, E E Blaak, J Plat
BACKGROUND: Changes in the microbiota composition have been implicated in the development of obesity and type 2 diabetes. However, not much is known on the involvement of gut microbiota in lipid and cholesterol metabolism. In addition, the gut microbiota might also be a potential source of plasma oxyphytosterol and oxycholesterol concentrations (oxidation products of plant sterols and cholesterol). Therefore, the aim of this study was to modulate the gut microbiota by antibiotic therapy to investigate effects on parameters reflecting cholesterol metabolism and oxyphytosterol concentrations...
June 21, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28646476/the-relationship-between-circulating-adiponectin-leptin-and-vaspin-with-bone-mineral-density-bmd-arterial-calcification-and-stiffness-a-cross-sectional-study-in-post-menopausal-women
#12
N Tanna, K Patel, A E Moore, D Dulnoan, S Edwards, G Hampson
OBJECTIVE: To explore the relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial stiffness and vascular calcification in post-menopausal women. We hypothesised that adipokines produced by adipose tissue may be mediators of bone and cardiovascular disease (CVD) and explain, in part, the observed association between osteoporosis and CVD. DESIGN: We studied 386 ambulant community dwelling postmenopausal women aged (mean [SD] 61 [6...
June 23, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28646177/hyperspectral-imaging-for-presymptomatic-detection-of-tobacco-disease-with-successive-projections-algorithm-and-machine-learning-classifiers
#13
Hongyan Zhu, Bingquan Chu, Chu Zhang, Fei Liu, Linjun Jiang, Yong He
We investigated the feasibility and potentiality of presymptomatic detection of tobacco disease using hyperspectral imaging, combined with the variable selection method and machine-learning classifiers. Images from healthy and TMV-infected leaves with 2, 4, and 6 days post infection were acquired by a pushbroom hyperspectral reflectance imaging system covering the spectral range of 380-1023 nm. Successive projections algorithm was evaluated for effective wavelengths (EWs) selection. Four texture features, including contrast, correlation, entropy, and homogeneity were extracted according to grey-level co-occurrence matrix (GLCM)...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645753/multi-immunoreaction-based-dual-color-capillary-electrophoresis-for-enhanced-diagnostic-reliability-of-thyroid-gland-disease
#14
Nain Woo, Su-Kang Kim, Seong Ho Kang
Thyroid-stimulating hormone (TSH) secretion plays a critical role in regulating thyroid gland function and circulating thyroid hormones (i.e., thyroxine (T4) and triiodothyronine (T3)). A novel multi-immunoreaction-based dual-color capillary electrophoresis (CE) technique was investigated in this study to assess its reliability in diagnosing thyroid gland disease via simultaneous detection of TSH, T3, and T4 in a single run of CE. Compared to the conventional immunoreaction technique, multi-immunoreaction of biotinylated streptavidin antibodies increased the selectivity and sensitivity for individual hormones in human blood samples...
June 16, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28645050/land-use-affects-total-dissolved-nitrogen-and-nitrate-concentrations-in-tropical-montane-streams-in-kenya
#15
Suzanne R Jacobs, Lutz Breuer, Klaus Butterbach-Bahl, David E Pelster, Mariana C Rufino
African tropical montane forests are facing fast and dynamic changes in land use. However, the impacts of these changes on stream water quality are understudied. This paper aims at assessing the effect of land use and physical catchment characteristics on stream water concentrations of dissolved organic carbon (DOC), total dissolved nitrogen (TDN), nitrate (NO3-N) and dissolved organic nitrogen (DON) in the Mau Forest, the largest tropical montane forest in Kenya. We conducted five synoptic stream water sampling campaigns at the outlets of 13-16 catchments dominated by either natural forest, smallholder agriculture or commercial tea and tree plantations...
June 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28644911/interictal-oscillations-and-focal-epileptic-disorders
#16
Maxime Lévesque, Pariya Salami, Zahra Shiri, Massimo Avoli
Neuronal network oscillations represent a main feature of the brain activity recorded in the EEG under normal and pathological conditions such as epilepsy. Specific oscillations occur between seizures in patients and in animal models of focal epilepsy, and thus they are termed interictal. According to their shape and intrinsic signal frequency, interictal oscillations are classified as spikes and high frequency oscillations (HFOs). Interictal spikes are recorded in the "wideband" EEG signal and consist of large-amplitude events that usually last less than 1 s; HFOs, in contrast, are extracted by amplifying the appropriately filtered EEG signal, and are usually categorized as ripples (80-200 Hz) and fast ripples (250-500 Hz)...
June 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28644810/action-recognition-using-3d-histograms-of-texture-and-a-multi-class-boosting-classifier
#17
Baochang Zhangm, Yun Yangm, Chen Chen, Linlin Yang, Jungong Han, Ling Shao
Human action recognition is an important yet challenging task. This paper presents a low-cost descriptor called 3D Histograms of Texture (3DHoTs) to extract discriminant features from a sequence of depth maps. 3DHoTs are derived from projecting depth frames onto three orthogonal Cartesian planes, i.e., the frontal, side and top planes, and thus compactly characterize the salient information of a specific action, on which texture features are calculated to represent the action. Besides this fast feature descriptor, a new multi-class boosting classifier (MBC) is also proposed to efficiently exploit different kinds of features in a unified framework for action classification...
June 21, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28644727/impact-of-time-and-assisted-donning-on-respirator-fit
#18
Brian Rembialkowski, Margaret Sietsema, Lisa Brosseau
The goal of this study was to examine the impact of assistance with donning and time on quantitative fit factors (FF) and pass rates for subjects wearing an N95 filtering facepiece respirator (FFR) and a non-certified adhesive mask. Fit factors were measured using two side-by-side TSI Portacount instruments sampling second-by-second simultaneous inside- and outside-facepiece concentrations. Naïve subjects made two visits at least one week apart. At each visit subjects first donned either the respirator or adhesive mask without assistance and performed a five-exercise fast fit test...
June 23, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28643695/highly-fluorescent-and-superparamagnetic-nanosystem-for-biomedical-applications
#19
Mariana P Cabrera, Paulo E Cabral Filho, Camila M C M Silva, Rita M Oliveira, Carlos F G C Geraldes, M Margarida C A Castro, Benilde F O Costa, Marta S C Henriques, José A Paixão, Luiz B Carvalho, Beate S Santos, Fernando Hallwass, Adriana Fontes, Giovannia A L Pereira
This work reports on highly fluorescent and superparamagnetic bimodal nanoparticles (BNPs) obtained by a simple and efficient method as probes for fluorescence analysis and/or contrast agents for MRI. These promising BNPs with small dimensions (ca. 17 nm) consist of superparamagnetic iron oxide nanoparticles (SPIONs) covalently bound with CdTe quantum dots (ca. 3 nm). The chemical structure of the magnetic part of BNPs is predominantly magnetite, with minor goethite and maghemite contributions, as shown by Mössbauer spectroscopy, which is compatible with the x-ray diffraction data...
July 14, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28643406/prussian-blue-nanocubes-with-an-open-framework-structure-coated-with-pedot-as-high-capacity-cathodes-for-lithium-sulfur-batteries
#20
Dawei Su, Michael Cortie, Hongbo Fan, Guoxiu Wang
It is shown that Prussian blue analogues (PBAs) can be a very competitive sulfur host for lithium-sulfur (Li-S) batteries. Sulfur stored in the large interstitial sites of a PBA host can take advantage of reversible and efficient insertion/extraction of both Li(+) and electrons, due to the well-trapped mobile dielectron redox centers in the well-defined host. It is demonstrated that Na2 Fe[Fe(CN)6 ] has a large open framework, and as a cathode, it both stores sulfur and acts as a polysulfide diffusion inhibitor based on the Lewis acid-base bonding effect...
June 23, 2017: Advanced Materials
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