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Santosh R Alluri, Patrick J Riss
A variety of substituted non-racemic aziridine-2-carboxylates equivalent to amino acids were prepared and subjected to ring opening reaction by [18F/19F]fluoride. The regio and stereospecific ring opening depends on the substituents on the nitrogen as well as both the carbons of aziridines. The applicability of the methods to afford access to 3-[18F/19F]fluoro amino acids are illustrated.
March 16, 2018: Organic & Biomolecular Chemistry
Ruili Shi, Pengju Wang, Lingli Tang, Xiaoming Huang, Yonggang Chen, Yan Su, Jijun Zhao
Using a genetic algorithm incorporated in density functional theory, we explore the ground state structures of fluoride anion-water clusters F-(H2O)n with n = 1-10. The F-(H2O)n clusters prefer structures in which the F- anion remains at the surface of the structure and coordinates with four water molecules, as the F-(H2O)n clusters have strong F--H2O interactions as well as strong hydrogen bonds between H2O molecules. The strong interaction between the F- anion and adjacent H2O molecule leads to a longer O-H distance in the adjacent molecule than in an individual water molecule...
March 16, 2018: Journal of Physical Chemistry. A
Marc A Bjurlin, Baris Turkbey, Andrew B Rosenkrantz, Sonia Gaur, Peter L Choyke, Samir S Taneja
Imaging is critically important for the diagnosis, staging, and management of men with high-risk prostate cancer. Conventional imaging modalities, including computed tomography and radionuclide bone scan have been employed for local and metastatic staging, but their performance has generally been poor. Sodium fluoride positron emission tomography is recommended when there is high suspicion for bone metastases despite a negative or indeterminate bone scan. Magnetic resonance imaging has advantages in local staging but its value depends on the extent of disease...
March 12, 2018: Urology
Stefanie Amend, Roland Frankenberger, Susanne Lücker, Eugen Domann, Norbert Krämer
OBJECTIVES: The present study aimed to establish Lactobacillus casei in a completely automated Streptococcus mutans-based artificial mouth model and to investigate secondary caries inhibiting properties of glass ionomer cements / resin composite groups in vitro. METHODS: Sixty extracted, caries-free human third molars were used for preparation of standardized class-V-cavities. Specimens were restored with a resin-modified (Photac Fil; PF) as well as a conventional glass ionomer cement (Ketac Molar; KM) and one resin composite bonded with and without conduction of etch-and-rinse technique (Prime&Bond NT, Ceram X mono; C+ERT, C)...
March 12, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Alejandro Amor-Coarasa, James Kelly, Shashikanth Ponnala, Yogindra Vedvyas, Anastasia Nikolopoulou, Clarence Williams, Moonsoo M Jin, J David Warren, John W Babich
INTRODUCTION: CXCR4 specific [18 F]-labeled positron emission tomography (PET) imaging agents are needed which would enable general distribution of the radiotracer for clinical investigation. We sought to synthesize, radiolabel and evaluate [18 F]RPS-544, a novel non-peptide CXCR4 antagonist as a CXCR4 specific probe. We compared [18 F]RPS-544 with the previously published [18 F]-3 ([18 F]RPS-510 in this paper) in a bi-lateral tumor model of differential CXCR4 expression for its ability to selectively target CXCR4 expression...
January 31, 2018: Nuclear Medicine and Biology
Clarisse Ribeiro, Carlos M Costa, Daniela M Correia, João Nunes-Pereira, Juliana Oliveira, Pedro Martins, Renato Gonçalves, Vanessa F Cardoso, Senentxu Lanceros-Méndez
Poly(vinylidene fluoride) (PVDF) and its copolymers are the polymers with the highest dielectric constants and electroactive responses, including piezoelectric, pyroelectric and ferroelectric effects. This semicrystalline polymer can crystallize in five different forms, each related to a different chain conformation. Of these different phases, the β phase is the one with the highest dipolar moment and the highest piezoelectric response; therefore, it is the most interesting for a diverse range of applications...
April 2018: Nature Protocols
Yogesh Patil, Panayiotis Bilalis, Georgios Polymeropoulos, Sarah R Almahdali, Nikos Hadjichristidis, Valentin O Rodionov
A well-defined amphiphilic miktoarm polymer incorporating poly(vinylidene fluoride) (PVDF), polystyrene (PS), and poly(ethylene glycol) (PEG) blocks was synthesized via a combination of atom-transfer radical polymerization (ATRP), iodine transfer radical polymerization (ITP), and copper-catalyzed azide-alkyne cycloaddition (CuAAC). Morphology and self-assembly of this star polymer were examined in organic solvents and in water. The aggregates formed in water were found to possess unusual frustrated topology due to immiscibility of PS and PVDF...
March 15, 2018: Molecular Pharmaceutics
Artur Lik, Sangeth Jenthra, Lars Fritze, Lars Müller, Khai-Nghi Truong, Holger Helten
The application of our newly developed B-C coupling method by catalytic Si/B exchange is demonstrated for the synthesis of a series of triarylboranes (1), monodisperse thienyl- and furylborane dimers (2) and trimers (9), extended oligomers (3) and polymers (3'), as well as mixed (oligo)thienyl-/furylboranes. The structures of 1aaTip, 1bbTip, and 2bbbMes*, determined by X-ray crystallography, reveal largely coplanar hetarene rings and BR3 environments, being most pronounced in the furylborane species. Photophysical investigations, supported by TD-DFT calculations, revealed pronounced pi-electron delocalization over the hetarene backbones including the boron centers...
March 15, 2018: Chemistry: a European Journal
Beatriz Bernardo-Maestro, Elisa Garrido-Martín, Fernando López-Arbeloa, Joaquín Pérez-Pariente, Luis Gómez-Hortigüela
In an attempt to promote the crystallization of chiral inorganic frameworks, we explore the ability of chiral (1R,2S)-ephedrine and its diastereoisomer (1S,2S)-pseudoephedrine to act as organic building blocks for the crystallization of hybrid organo-inorganic aluminophosphate frameworks in the presence of fluoride. These molecules were selected because of their particular molecular asymmetric structure, which enables a rich supramolecular chemistry and a potential chiral recognition phenomenon during crystallization...
March 15, 2018: Physical Chemistry Chemical Physics: PCCP
Mahmood Yousefi, Mehdi Yaseri, Ramin Nabizadeh, Elham Hooshmand, Mohsen Jalilzadeh, Amir Hossein Mahvi, Ali Akbar Mohammadi
Hypertension is becoming a global epidemic for both rural and urban populations; it is a major public health challenge in Iran. Fluoride can be a risk factor for hypertension. Cross-sectional analysis was conducted in two study areas to assess the relation of fluoride with blood pressure prevalence, BMI, waist circumference, and waist-to-hip ratio (WHR) among different age groups in both sexes. The mean value of fluoride concentration in the drinking water from the four study villages varied from 0.68 to 10...
March 14, 2018: Biological Trace Element Research
Vahid Kazemi Moghaddam, Mahmood Yousefi, Ahmad Khosravi, Mehdi Yaseri, Amir Hossein Mahvi, Mostafa Hadei, Ali Akbar Mohammadi, Zahrasadat Robati, Adel Mokammel
The presence of fluoride in drinking water can be either beneficial or harmful for human health, depending on its concentration. Most adverse effects of fluoride are observed at high concentrations (above 1.5 mg/L). This study was aimed to evaluate the effect of fluoride concentrations in drinking water on spontaneous abortion in two regions: one with low fluoride concentration and another with high fluoride concentration. The results showed that there is a relationship between the concentration of fluoride in drinking water and abortion, so that the risk of abortion increased at high concentrations of fluoride...
March 14, 2018: Biological Trace Element Research
Kai Lu, Wen Huang, Junxiong Guo, Tianxun Gong, Xiongbang Wei, Bing-Wei Lu, Si-Yi Liu, Bin Yu
A flexible 4 × 4 sensor array with 16 micro-scale capacitive units has been demonstrated based on flexible piezoelectric poly(vinylidene fluoride) (PVDF) film. The piezoelectricity and surface morphology of the PVDF were examined by optical imaging and piezoresponse force microscopy (PFM). The PFM shows phase contrast, indicating clear interface between the PVDF and electrode. The electro-mechanical properties show that the sensor exhibits excellent output response and an ultra-high signal-to-noise ratio...
March 14, 2018: Nanoscale Research Letters
Adimalla Narsimha
Fluoride beyond desirable amounts(0.6-1.5 mg/L) in groundwater is a major problem and fluorosis is a very dangerous and deadly disease affecting millions of people across the World (Bell and Ludwig, 1970; Adimalla and Venkatayogi, 2017; Narsimha and Sudarshan, 2013, 2017a, 2017b) [1], [2], [3], [4], [5]. The investigated area is located in north-eastern part of Medak district, Telangana state and fluoride concentration in groundwater samples was measured by ion selective electrode method and its ranges from 0...
February 2018: Data in Brief
Glen M Blake, Tanuj Puri, Musib Siddique, Michelle L Frost, Amelia E B Moore, Ignac Fogelman
Dynamic positron emission tomography (PET) imaging with fluorine-18 labelled sodium fluoride ([18 F]NaF) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. Today, hybrid PET and computed tomography (CT) dual-modality systems (PET/CT) are widely available, and [18 F]NaF PET/CT offers a convenient non-invasive method of studying bone formation at the important osteoporotic fracture sites at the hip and spine, as well as sites of pure cortical or trabecular bone...
February 2018: Quantitative Imaging in Medicine and Surgery
Joshua N Edokpayi, John O Odiyo, Elizabeth O Popoola, Titus A M Msagati
Background: Access to clean and safe drinking water is still a problem in developing countries and more pronounced in rural areas. Due to erratic supply of potable, rural dwellers often seek for an alternative source of water to meet their basic water needs. The objective of this study is to monitor the microbiological and physicochemical water quality parameters of Nzhelele River which is a major alternative source of drinking water to villages along its course in Limpopo province of South Africa...
2018: Open Microbiology Journal
A Augusto Peluso, Jesper Bork Bertelsen, Kenneth Andersen, Tenna Pavia Mortensen, Pernille B Hansen, Colin Sumners, Michael Bader, Robson A Santos, U Muscha Steckelings
The angiotensin AT2 receptor (AT2 R) promotes vasodilation by nitric oxide (NO) release from endothelial cells. However, the mechanisms underlying the AT2 R-induced stimulation of endothelial NO synthase (eNOS) is still not completely understood. Therefore, we investigated whether in addition to the known AT2 R-mediated phosphorylation of eNOS at Ser1177, activation of phosphatases and dephosphorylation of eNOS at Tyr657 and Thr495 are also involved. Human Aortic Endothelial Cells (HAEC) were stimulated with the AT2 R-agonist C21 (1µM) in the presence or absence of either PD123319 (10µM; AT2 R-antagonist), L-NAME (10µM; eNOS inhibitor), MK-2206 (100nM; Akt-inhibitor) sodium fluoride (1nM; serine/threonine-phosphatase inhibitor) or sodium orthovanadate (10nM; tyrosine-phosphatase inhibitor)...
March 14, 2018: Clinical Science (1979-)
Eva Cepova, Martina Cicvakova, Peter Kolarcik, Neda Markovska, Andrea Madarasova Geckova
BACKGROUND: Modification of health literacy (HL) is an important factor for improving and maintaining oral health. The aim of the study is to examine the association of HL with oral health-promoting behaviour (OHPB) and assess possible mediating effects of HL on the impact of socioeconomic status on OHPB. METHODS: A cross-sectional questionnaire survey on the Slovak general adult population (N = 360, mean age 39) was conducted in 2014 and 2015. The association of HL (9 domains of the Health Literacy Questionnaire) and OHPB was analysed using logistic regression models adjusted for gender, age and educational level...
March 14, 2018: BMC Oral Health
Sushovan Paladhi, In-Soo Hwang, Eun Jeong Yoo, Do Hyun Ryu, Choong Eui Song
A practical and highly enantioselective nonenzymatic kinetic resolution of racemic β-hydroxy carbonyl (aldol) compounds through enantioselective dehydration process was developed using a cation-binding Song's oligoethylene glycol (oligoEG) catalyst with potassium fluoride (KF) as base. A wide range of racemic aldols was resolved with extremely high selectivity factors ( s = up to 2393) under mild reaction conditions. This protocol is easily scalable. It provides an alternative approach for the syntheses of diverse biologically and pharmaceutically relevant chiral aldols in enantiomerically pure form...
March 14, 2018: Organic Letters
Zihan An, Fengying Dai, Chenjie Wei, Yiping Zhao, Li Chen
Membrane surface design is significant for the development and application of synthetic polymer hemodialysis membranes. In this study, the influence of zwitterionic cysteine on poly(vinylidene fluoride) (PVDF) hollow fiber membrane was investigated. The polydopamine layer was formed through dopamine self-polymerization on PVDF membrane surface, and then cysteine was covalent grafted onto the layer to improve the anti-biofouling property and hemocompatibility. The elementary composition of membrane surfaces was characterized by X-ray photoelectron spectroscopy...
March 14, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Ane Urtiaga, Alvaro Soriano, Jordi Carrillo-Abad
The concerns about the undesired impacts on human health and the environment of long chain perfluorinated alkyl substances (PFASs) have driven industrial initiatives to replace PFASs by shorter chain fluorinated homologues. 6:2 fluorotelomer sulfonic acid (6:2 FTSA) is applied as alternative to PFOS in metal plating and fluoropolymer manufacture. This study reports the electrochemical treatment of aqueous 6:2 FTSA solutions on microcrystalline BDD anodes. Bench scale batch experiments were performed, focused on assessing the effect of the electrolyte and the applied current density (5-600 A m-2 ) on the removal of 6:2 FTSA, the reduction of total organic carbon (TOC) and the fluoride release...
March 7, 2018: Chemosphere
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