Lauren J Hodkinson, Connor Smith, H Skye Comstra, Bukola A Ajani, Eric H Albanese, Kawsar Arsalan, Alvaro Perez Daisson, Katherine B Forrest, Elijah H Fox, Matthew R Guerette, Samia Khan, Madeleine P Koenig, Shivani Lam, Ava S Lewandowski, Lauren J Mahoney, Nasserallah Manai, JonCarlo Miglay, Blake A Miller, Olivia Milloway, Nhi Ngo, Vu D Ngo, Nicole F Oey, Tanya A Punjani, HaoMin SiMa, Hollis Zeng, Casey A Schmidt, Leila E Rieder
BACKGROUND: Cells orchestrate histone biogenesis with strict temporal and quantitative control. To efficiently regulate histone biogenesis, the repetitive Drosophila melanogaster replication-dependent histone genes are arrayed and clustered at a single locus. Regulatory factors concentrate in a nuclear body known as the histone locus body (HLB), which forms around the locus. Historically, HLB factors are largely discovered by chance, and few are known to interact directly with DNA. It is therefore unclear how the histone genes are specifically targeted for unique and coordinated regulation...
September 21, 2023: BMC genomic data