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Hox regulation

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https://www.readbyqxmd.com/read/28798948/hoxb13-mutations-and-binding-partners-in-prostate-development-and-cancer-function-clinical-significance-and-future-directions
#1
Hannah Brechka, Raj R Bhanvadia, Calvin VanOpstall, Donald J Vander Griend
The recent and exciting discovery of germline HOXB13 mutations in familial prostate cancer has brought HOX signaling to the forefront of prostate cancer research. An enhanced understanding of HOX signaling, and the co-factors regulating HOX protein specificity and transcriptional regulation, has the high potential to elucidate novel approaches to prevent, diagnose, stage, and treat prostate cancer. Toward our understanding of HOX biology in prostate development and prostate cancer, basic research in developmental model systems as well as other tumor sites provides a mechanistic framework to inform future studies in prostate biology...
June 2017: Genes & Diseases
https://www.readbyqxmd.com/read/28795084/multi-species-alignments-of-c-elegans-lin-11-intronic-sequences-and-putative-transcriptional-regulators
#2
Siavash Amon, Bhagwati P Gupta
This data article contains multi-species alignments of the regulatory region of C. elegans LIM-HOX gene lin-11 and lists of transcription factors that are predicted to bind to lin-11 enhancers and regulate expression in amphid neurons. For further details and experimental findings please refer to the article by Amon and Gupta in Developmental Biology (S. Amon, B.P. Gupta, 2017) [1].
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28790414/modelling-the-evolution-of-transcription-factor-binding-preferences-in-complex-eukaryotes
#3
Antonio Rosanova, Alberto Colliva, Matteo Osella, Michele Caselle
Transcription factors (TFs) exert their regulatory action by binding to DNA with specific sequence preferences. However, different TFs can partially share their binding sequences due to their common evolutionary origin. This "redundancy" of binding defines a way of organizing TFs in "motif families" by grouping TFs with similar binding preferences. Since these ultimately define the TF target genes, the motif family organization entails information about the structure of transcriptional regulation as it has been shaped by evolution...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771970/segmental-arithmetic-summing-up-the-hox-gene-regulatory-network-for-hindbrain-development-in-chordates
#4
REVIEW
Hugo J Parker, Robb Krumlauf
Organization and development of the early vertebrate hindbrain are controlled by a cascade of regulatory interactions that govern the process of segmentation and patterning along the anterior-posterior axis via Hox genes. These interactions can be assembled into a gene regulatory network that provides a framework to interpret experimental data, generate hypotheses, and identify gaps in our understanding of the progressive process of hindbrain segmentation. The network can be broadly separated into a series of interconnected programs that govern early signaling, segmental subdivision, secondary signaling, segmentation, and ultimately specification of segmental identity...
August 3, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28764892/expression-and-function-of-spineless-orthologs-correlate-with-distal-deutocerebral-appendage-morphology-across-arthropoda
#5
Emily V W Setton, Logan E March, Erik D Nolan, Tamsin E Jones, Holly Cho, Ward C Wheeler, Cassandra G Extavour, Prashant P Sharma
The deutocerebral (second) head segment is putatively homologous across Arthropoda, in spite of remarkable disparity of form and function of deutocerebral appendages. In Mandibulata this segment bears a pair of sensory antennae, whereas in Chelicerata the same segment bears a pair of feeding appendages called chelicerae. Part of the evidence for the homology of deutocerebral appendages is the conserved function of homothorax (hth), which has been shown to specify antennal or cheliceral fate in the absence of Hox signaling, in both mandibulate and chelicerate exemplars...
July 29, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28731193/promotion-of-glycolysis-by-hotair-through-glut1-upregulation-via-mtor-signaling
#6
Shibo Wei, Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Zhihong Zong, Xiangdong Hua, Dongming Su, Hongzhi Sun, Hangyu Li, Zhen Liu
The long non-coding RNA HOX transcript antisense RNA (HOTAIR) plays a key role in the progression of various carcinomas. However, whether or not HOTAIR influences glucose metabolism and the specific underlying mechanism in hepatocellular carcinoma (HCC) cells remain unclear. In the present study, we found markedly increased HOTAIR expression in 84 HCC tissues and demonstrated that HOTAIR overexpression promoted cell proliferation using Cell Counting Kit-8. The effect on glucose metabolism regulated by HOTAIR in HCC cells was determined by detecting lactate and glucose levels: HOTAIR promoted glycolysis by upregulating glucose transporter isoform 1 (GLUT1) and activating mammalian target of rapamycin (mTOR) signaling, whereas knockdown of HOTAIR suppressed this effect...
July 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28723696/advanced-glycation-end-products-downregulate-hoxa9ec-through-activation-of-nuclear-factor-kappa-b-by-reciprocal-interaction
#7
Qian-Qian Zhu, Dong-Lin Li, Yang-Yan He, Zi-Heng Wu, Lu Tian, Cheng-Fei Zheng, Nan Zhang, Hong-Kun Zhang
Advanced glycation end-products (AGEs) have been recognized as an important pathophysiological mechanism in endothelial dysfunction during diabetic atherogenesis. Homeobox (Hox) genes have been identified as playing a regulatory role in the adult cardiovascular system. Regulation of HoxA9EC is involved in diabetic endothelial dysfunction, but the mechanism of HoxA9EC regulation has remained undefined. Here, we sought to investigate how HoxA9EC is regulated in AGE-induced endothelial dysfunction and to explore the mechanism involved...
July 20, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28715417/a-hox-complex-activates-and-potentiates-the-epidermal-growth-factor-signaling-pathway-to-specify-drosophila-oenocytes
#8
Guolun Wang, Lisa Gutzwiller, David Li-Kroeger, Brian Gebelein
Hox transcription factors specify distinct cell types along the anterior-posterior axis of metazoans by regulating target genes that modulate signaling pathways. A well-established example is the induction of Epidermal Growth Factor (EGF) signaling by an Abdominal-A (Abd-A) Hox complex during the specification of Drosophila hepatocyte-like cells (oenocytes). Previous studies revealed that Abd-A is non-cell autonomously required to promote oenocyte fate by directly activating a gene (rhomboid) that triggers EGF secretion from sensory organ precursor (SOP) cells...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28698559/repression-of-abd-b-by-polycomb-is-critical-for-cell-identity-maintenance-in-adult-drosophila-testis
#9
Shuo Zhang, Chenyu Pan, Xiangdong Lv, Wei Wu, Hao Chen, Wenqing Wu, Hailong Wu, Lei Zhang, Yun Zhao
Hox genes play a fundamental role in regulating animal development. However, less is known about their functions on homeostasis maintenance in adult stem cells. Here, we report that the repression of an important axial Hox gene, Abdominal-B (Abd-B), in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695962/gdf11-smad-signalling-and-cdx-proteins-cooperate-to-activate-the-hoxc8-early-enhancer-in-hepg2-cells
#10
Stephen J Gaunt
Developing anatomy along the head-tail axis of bilaterian embryos is specified, to a large extent, by the overlapping patterns of expression of the Hox genes. Hox gene enhancers respond to a variety of signals in order to regulate these discreet domains of expression. For mouse Hoxc8, the 399bp "early enhancer" plays a major role. Activation of this enhancer is now examined using luciferase expression constructs transfected into HepG2 cells. Constructs are activated by the combined actions of Gdf11/Smad and Cdx protein signalling pathways, both of which are functional in early embryos...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/28694486/ctcf-binding-landscape-in-jawless-fish-with-reference-to-hox-cluster-evolution
#11
Mitsutaka Kadota, Yuichiro Hara, Kaori Tanaka, Wataru Takagi, Chiharu Tanegashima, Osamu Nishimura, Shigehiro Kuraku
The nuclear protein CCCTC-binding factor (CTCF) contributes as an insulator to chromatin organization in animal genomes. Currently, our knowledge of its binding property is confined mainly to mammals. In this study, we identified CTCF homologs in extant jawless fishes and performed ChIP-seq for the CTCF protein in the Arctic lamprey. Our phylogenetic analysis suggests that the lamprey lineage experienced gene duplication that gave rise to its unique paralog, designated CTCF2, which is independent from the previously recognized duplication between CTCF and CTCFL...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674422/increased-methylation-and-decreased-expression-of-homeobox-genes-tlx1-hoxa10-and-dlx5-in-human-placenta-are-associated-with-trophoblast-differentiation
#12
Boris Novakovic, Thierry Fournier, Lynda K Harris, Joanna James, Claire T Roberts, Hannah E J Yong, Bill Kalionis, Danièle Evain-Brion, Peter R Ebeling, Euan M Wallace, Richard Saffery, Padma Murthi
Homeobox genes regulate embryonic and placental development, and are widely expressed in the human placenta, but their regulatory control by DNA methylation is unclear. DNA methylation analysis was performed on human placentae from first, second and third trimesters to determine methylation patterns of homeobox gene promoters across gestation. Most homeobox genes were hypo-methylated throughout gestation, suggesting that DNA methylation is not the primary mechanism involved in regulating HOX genes expression in the placenta...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28669171/hotair-long-noncoding-rna-is-not-a-biomarker-for-acute-myeloid-leukemia-aml-in-iranian-patients
#13
Arezou Sayad, Abbas Hajifathali, Amir Ali Hamidieh, Elham Roshandel, Mohammad Taheri
Accumulating evidence indicates that lncRNAs may have potential as new biomarkers to predict prognosis of different human cancers. HOTAIR lncRNA, transcribed from the human HOX locus, has been suggested to regulate gene expression of important target genes and up-regulation has been noted in malignancies. The role of HOX transcript antisense RNA in acute myeloid leukemia (AML) was investigated in the present case control study. HOTAIR expression was evaluated in blood samples of twenty five de novo AML patients and fifty healthy controls using real-time quantitative reverse transcription-PCR (qRT-PCR)...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28649807/microrna-196-regulates-hox-gene-expression-in-human-gluteal-adipose-tissue
#14
Adeline Divoux, Hui Xie, Jian-Liang Li, Kalypso Karastergiou, Ranjan J Perera, R Jeffrey Chang, Susan K Fried, Steven R Smith
OBJECTIVE: Lower body fat is associated with diminishing cardiometabolic risk. Physiological differences between gluteofemoral and abdominal subcutaneous adipocyte functions are known, but the molecular basis for depot differences in adipocyte function is poorly understood. The objective of this study was to identify depot differences in microRNA (miRNA) expression in human abdominal and gluteofemoral subcutaneous adipose tissues and their implication in gene regulation. METHODS: Abdominal and gluteofemoral adipose tissue aspirates obtained from 18 participants (9 male and 9 female, age 30 ± 1...
August 2017: Obesity
https://www.readbyqxmd.com/read/28649178/hotair-a-key-regulator-in-gynecologic-cancers
#15
REVIEW
Jing Li, Jing Wang, Yan Zhong, Ruixia Guo, Danxia Chu, Haifeng Qiu, Zhongfu Yuan
Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes. HOTAIR promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and signaling pathways. HOTAIR is deregulated in many human cancers; despite its critical roles in health and disease, the underlying mechanisms governing HOTAIR function are unknown...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28642242/specific-expression-and-function-of-the-six3-optix-in-drosophila-serially-homologous-organs
#16
Amer Al Khatib, Natalia Siomava, Antonella Iannini, Nico Posnien, Fernando Casares
Organ size and pattern results from the integration of two positional information systems. One global information system, encoded by the Hox genes, links organ type with position along the main body axis. Within specific organs, local information is conveyed by signaling molecules that regulate organ growth and pattern. The mesothoracic (T2) wing and the metathoracic (T3) haltere of Drosophila represent a paradigmatic example of this coordination. The Hox gene Ultrabithorax (Ubx), expressed in the developing T3, selects haltere identity by, among other processes, modulating the production and signaling efficiency of Dpp, a BMP2-like molecule that acts as a major regulator of size and pattern...
August 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28621427/adhfe1-a-novel-enzyme-involved-in-retinoic-acid-dependent-hox-activation
#17
Yehuda Shabtai, Natalie Shukrun, Abraham Fainsod
Retinoic acid (RA) signaling is a central pathway regulating anterior-posterior patterning of the embryo through its targets, the Hox genes. RA is produced by two sequential oxidations from vitamin A (retinol) and this biosynthesis has to be regulated temporally, spatially and quantitatively. Mining Xenopus embryonic expression databases identified a novel component of the RA metabolic network, ADHFe1. Using Xenopus laevis embryos as our experimental system we determined the temporal and spatial pattern of AdhFe1 expression...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/28614722/quantitative-analysis-of-the-dna-methylation-sensitivity-of-transcription-factor-complexes
#18
Judith F Kribelbauer, Oleg Laptenko, Siying Chen, Gabriella D Martini, William A Freed-Pastor, Carol Prives, Richard S Mann, Harmen J Bussemaker
Although DNA modifications play an important role in gene regulation, the underlying mechanisms remain elusive. We developed EpiSELEX-seq to probe the sensitivity of transcription factor binding to DNA modification in vitro using massively parallel sequencing. Feature-based modeling quantifies the effect of cytosine methylation ((5)mC) on binding free energy in a position-specific manner. Application to the human bZIP proteins ATF4 and C/EBPβ and three different Pbx-Hox complexes shows that (5)mCpG can both increase and decrease affinity, depending on where the modification occurs within the protein-DNA interface...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28609438/peg3-control-on-the-mammalian-msl-complex
#19
An Ye, Hana Kim, Joomyeong Kim
Peg3 (paternally expressed gene 3) encodes a DNA-binding protein that functions as a transcriptional repressor. Recent studies revealed that PEG3 binds to Msl1 (male-specific lethal 1) and Msl3, the two main components of the MSL complex. In the current study, we investigated potential roles of Peg3 in controlling its downstream genes through H4K16ac, the histone modification by the MSL complex. According to the results, complete removal of PEG3 resulted in up-regulation of Msl1 and Msl3, and subsequently an increase in the global levels of H4K16ac, confirming PEG3 as a transcriptional repressor for MSL during mammalian development...
2017: PloS One
https://www.readbyqxmd.com/read/28605223/homeobox-c10-inhibits-the-osteogenic-differentiation-potential-of-mesenchymal-stem-cells
#20
Guoqing Li, Nannan Han, Haoqing Yang, Liping Wang, Xiao Lin, Shu Diao, Juan Du, Rui Dong, Songlin Wang, Zhipeng Fan
PURPOSE: Mesenchymal stem cells (MSCs) are a reliable cell source for tissue regeneration. However, the molecular mechanisms underlying the directed differentiation of MSCs remain unclear which impedes potential clinical applications. Recent studies have discovered that HOX genes are involved in the differentiation regulation of MSCs and bone formation. In this study, we investigate the HOXC10 function in the osteogenic differentiation potential of MSCs. MATERIALS AND METHODS: Stem cells from apical papilla (SCAPs) and adipose-derived stem cells (ADSCs) were used in this study...
June 12, 2017: Connective Tissue Research
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