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https://www.readbyqxmd.com/read/28637308/three-dimensional-right-ventricular-regional-deformation-and-survival-in-pulmonary-hypertension
#1
Pamela Moceri, Nicolas Duchateau, Delphine Baudouy, Elie-Dan Schouver, Sylvie Leroy, Fabien Squara, Emile Ferrari, Maxime Sermesant
Aims: Survival in pulmonary hypertension (PH) relates to right ventricular (RV) function. However, the RV unique anatomy and structure limit 2D analysis and its regional 3D function has not been studied yet. The aim of this study was to assess the implications of global and regional 3D RV deformation on clinical condition and survival in adults with PH and healthy controls. Methods and results: We collected a prospective longitudinal cohort of 104 consecutive PH patients and 34 healthy controls between September 2014 and December 2015...
June 15, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28637147/musculoskeletal-complaints-in-individuals-with-finger-or-partial-hand-amputations-in-the-netherlands-a-cross-sectional-study
#2
Sjoukje E Bouma, Sietke G Postema, Raoul M Bongers, Pieter U Dijkstra, Corry K van der Sluis
PURPOSE: To compare the prevalence of musculoskeletal complaints (MSCs) in individuals with finger or partial hand amputations (FPHAs) with a control group and to explore the effect and predictors of MSCs in individuals with FPHAs. METHOD: A questionnaire-based cross-sectional study was conducted. The primary outcome measures were: prevalence of MSCs, health status, pain-related disability, physical work demands, work productivity, and hand function. RESULTS: The response rate was 61%...
February 24, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28637143/validity-and-reliability-of-an-activity-monitor-to-quantify-arm-movements-and-activity-in-adults-following-distal-radius-fracture
#3
Andrea M Bruder, Jodie A McClelland, Nora Shields, Karen J Dodd, Raphael Hau, Alexander T M van de Water, Nicholas F Taylor
PURPOSE: To examine the validity and reliability of an activity monitor to estimate upper limb activity. METHODS: Thirty-two adults after distal radial fracture were recruited. 15 adults performed five upper limb activities during two testing sessions, one week apart to investigate criterion validity against the criterion reference of three-dimensional motion analysis, convergent validity, and test-retest reliability. 17 adults in two therapy groups wore monitors for three consecutive days at baseline and six weeks post-intervention...
February 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28636915/probing-the-structural-dynamics-of-the-nmda-receptor-activation-by-coarse-grained-modeling
#4
Wenjun Zheng, Han Wen, Gary J Iacobucci, Gabriela K Popescu
N-Methyl-D-aspartate (NMDA) receptors are glutamate-gated excitatory channels that play essential roles in brain functions. High-resolution structures have been solved for an allosterically inhibited and agonist-bound form of a functional NMDA receptor; however, other key functional states (particularly the active open-channel state) were only resolved at moderate resolutions by cryo-electron microscopy (cryo-EM). To decrypt the mechanism of the NMDA receptor activation, structural modeling is essential to provide presently missing information about structural dynamics...
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28636347/the-structure-and-dynamics-of-alginate-gels-crosslinked-by-polyvalent-ions-probed-via-solid-state-nmr-spectroscopy
#5
Jiří Brus, Martina Urbanová, Jiri Czernek, Miroslava Pavelkova, Katerina Kubova, Jakub Vyslouzil, Sabina Abbrent, Rafal Konefal, Jiri Horsky, David Vetchy, Jan Vysloužil, Pavel Kulich
Alginate gels are an outstanding biomaterial widely applicable in tissue engineering, medicine, and pharmacy for cell transplantation, wound healing and efficient bioactive agent delivery, respectively. This contribution provides new and comprehensive insight into the atomic-resolution structure and dynamics of polyvalent ion-crosslinked alginate gels in microbead formulations. By applying various advanced solid-state NMR (ssNMR) spectroscopy techniques, we verified the homogenous distribution of the crosslinking ions in the alginate gels and the high degree of ion exchange...
June 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28636076/prevalence-and-impact-of-obesity-in-people-with-haemophilia-review-of-literature-and-expert-discussion-around-implementing-weight-management-guidelines
#6
REVIEW
S Kahan, A Cuker, R F Kushner, J Maahs, M Recht, T Wadden, T Willis, S Majumdar, D Ungar, D Cooper
Obesity affects more than 35% of Americans, increasing the risk of more than 200 comorbid conditions, impaired quality of life and premature mortality. This review aimed to summarize literature published over the past 15 years regarding the prevalence and impact of obesity in people with haemophilia (PWH) and to discuss implementing general guidelines for weight management in the context of the haemophilia comprehensive care team. Although few studies have assessed the effects of obesity on haemophilia-specific outcomes, existing evidence indicates an important impact of weight status on lower extremity joint range of motion and functional disability, with potentially important effects on overall quality of life...
June 21, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28635403/psychomotor-skills-assessment-by-motion-analysis-in-minimally-invasive-surgery-on-an-animal-organ
#7
Erlend Fagertun Hofstad, Cecilie Våpenstad, Lars Eirik Bø, Thomas Langø, Esther Kuhry, Ronald Mårvik
BACKGROUND: A high level of psychomotor skills is required to perform minimally invasive surgery (MIS) safely. To be able to measure these skills is important in the assessment of surgeons, as it enables constructive feedback during training. The aim of this study was to test the validity of an objective and automatic assessment method using motion analysis during a laparoscopic procedure on an animal organ. MATERIAL AND METHODS: Experienced surgeons in laparoscopy (experts) and medical students (novices) performed a cholecystectomy on a porcine liver box model...
February 8, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28634743/comminuted-olecranon-fractures-biomechanical-testing-of-locked-versus-minifragment-non-locked-plate-fixation
#8
David S Wellman, Scott M Tucker, Josh R Baxter, Nadine C Pardee, Lionel E Lazaro, Christopher S Smith, Dean G Lorich, David L Helfet
INTRODUCTION: Open reduction and internal fixation has long been accepted as optimal treatment for displaced olecranon fractures based on poor results seen with conservative management. With the presence of comminution, tension-band wiring constructs are contraindicated due to tendency to compress through fragments, thereby shortening the articular segment. Therefore, plate fixation is typically employed. Our hypothesis was that in a comminuted fracture model, 2.7 mm reconstruction plating without locking screws will perform equally to 3...
June 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28634634/pain-and-fracture-related-limitations-persist-6%C3%A2-months-after-a-fragility-fracture
#9
Joanna E M Sale, Lucy Frankel, Stephen Thielke, Larry Funnell
Our objective was to examine the experience of pain after a fracture beyond the conventional healing duration of 6 months. We conducted a phenomenological study in participants who were deemed high risk for future fracture and recruited through an urban fracture clinic in Toronto, Canada. In-depth interviews were conducted with questions addressing the experience of pain, the status of recovery from the fracture, ways in which the fracture affected one's daily activities, and interactions with health care providers...
June 20, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28634376/structural-basis-to-stabilize-the-domain-motion-of-bard1-ard-brct-by-cstf50
#10
Rajan Kumar Choudhary, Mohd Quadir Siddiqui, Pankaj S Thapa, Nikhil Gadewal, Senthil Kumar Nachimuthu, Ashok K Varma
BRCA1 associated ring domain protein 1(BARD1) is a tumor suppressor protein having a wide role in cellular processes like cell-cycle checkpoint, DNA damage repair and maintenance of genomic integrity. Germ-line mutation Gln 564 His discovered in linker region of BARD1 leads to loss of binding to Cleavage stimulating factor (CstF50), which in turn instigates the premature mRNA transcript formation and apoptosis. We have studied the dynamics of ARD domain present in the BARD1 wild-type and mutant protein in association with CstF50 using biophysical, biochemical and molecular dynamics simulations...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633995/quantitative-mri-study-of-the-permeability-of-peritumoral-brain-edema-in-lung-cancer-patients-with-brain-metastases
#11
Dan Wang, Ming-Liang Wang, Yue-Hua Li
PURPOSE: To use Ktrans to evaluate the aggressiveness and vascular permeability of peritumoral edema in cases of lung cancer brain metastases. MATERIALS AND METHODS: A total of 68 lung cancer patients with 92 metastatic brain lesions were enrolled (20 metastatic lesions only in the gray matter -group 1; and 72 metastatic lesions located in the gray and white matter junction -group 2). All patients underwent MRI examination, which involved a dual angle (2° and 15°) enhanced T1W-VIBE (volume interpolated breath-hold examination) sequence to calculate the T1 parameter map...
June 17, 2017: Brain Research
https://www.readbyqxmd.com/read/28632753/mait-cells-launch-a-rapid-robust-and-distinct-hyperinflammatory-response-to-bacterial-superantigens-and-quickly-acquire-an-anergic-phenotype-that-impedes-their-cognate-antimicrobial-function-defining-a-novel-mechanism-of-superantigen-induced-immunopathology
#12
Christopher R Shaler, Joshua Choi, Patrick T Rudak, Arash Memarnejadian, Peter A Szabo, Mauro E Tun-Abraham, Jamie Rossjohn, Alexandra J Corbett, James McCluskey, John K McCormick, Olivier Lantz, Roberto Hernandez-Alejandro, S M Mansour Haeryfar
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome (TSS). Given the rapidity with which TSS develops, designing timely and truly targeted therapies for this syndrome requires identification of key mediators of the cytokine storm's initial wave. Equally important, early host responses to SAgs can be accompanied or followed by a state of immunosuppression, which in turn jeopardizes the host's ability to combat and clear infections...
June 2017: PLoS Biology
https://www.readbyqxmd.com/read/28632333/from-chemical-topology-to-molecular-machines-nobel-lecture
#13
REVIEW
Jean-Pierre Sauvage
To a large extent, the field of "molecular machines" started after several groups were able to prepare, reasonably easily, interlocking ring compounds (named catenanes for compounds consisting of interlocking rings and rotaxanes for rings threaded by molecular filaments or axes). Important families of molecular machines not belonging to the interlocking world were also designed, prepared, and studied but, for most of them, their elaboration was more recent than that of catenanes or rotaxanes. Since the creation of interlocking ring molecules is so important in relation to the molecular machinery area, we will start with this aspect of our work...
June 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28632061/the-effect-of-unilateral-arm-swing-motion-on-lower-extremity-running-mechanics-associated-with-injury-risk
#14
Cristine Agresta, Christian R Ward, W Geoffrey Wright, Carole A Tucker
Many field sports involve equipment that restricts one or both arms from moving while running. Arm swing during running has been examined from a biomechanical and physiologic perspective but not from an injury perspective. Moreover, only bilateral arm swing suppression has been studied with respect to running. The purpose of this study was to determine the influence of running with one arm restrained on lower extremity mechanics associated with running or sport-related injury. Fifteen healthy participants ran at a self-selected speed with typical arm swing, with one arm restrained and with both arms restrained...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28632058/assessment-of-model-based-image-matching-for-future-reconstruction-of-unhelmeted-sport-head-impact-kinematics
#15
Gregory J Tierney, Hamed Joodaki, Tron Krosshaug, Jason L Forman, Jeff R Crandall, Ciaran K Simms
Player-to-player contact inherent in many unhelmeted sports means that head impacts are a frequent occurrence. Model-Based Image-Matching (MBIM) provides a technique for the assessment of three-dimensional linear and rotational motion patterns from multiple camera views of a head impact event, but the accuracy is unknown for this application. The goal of this study is to assess the accuracy of the MBIM method relative to reflective marker-based motion analysis data for estimating six degree of freedom head displacements and velocities in a staged pedestrian impact scenario at 40 km/h...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28632057/rotation-sequence-to-report-humerothoracic-kinematics-during-3d-motion-involving-large-horizontal-component-application-to-the-tennis-forehand-drive
#16
Thomas Creveaux, Violaine Sevrez, Raphaël Dumas, Laurence Chèze, Isabelle Rogowski
The aim of this study was to examine the respective aptitudes of three rotation sequences (YtXf'Yh'', ZtXf'Yh'', and XtZf'Yh'') to effectively describe the orientation of the humerus relative to the thorax during a movement involving a large horizontal abduction/adduction component: the tennis forehand drive. An optoelectronic system was used to record the movements of eight elite male players, each performing ten forehand drives. The occurrences of gimbal lock, phase angle discontinuity and incoherency in the time course of the three angles defining humerothoracic rotation were examined for each rotation sequence...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28632049/kinematic-comparison-of-the-seoi-nage-judo-technique-between-elite-and-college-athletes
#17
Takanori Ishii, Michiyoshi Ae, Yuta Suzuki, Yasuto Kobayashi
This study sought to identify biomechanical factors that determine fast and skilful execution of the seoi-nage (shoulder throw) technique by comparing kinematics between elite and college judo athletes. Three-dimensional motion data were captured using a VICON-MX system with 18 cameras operating at 250 Hz as three male elite and seven male college judo athletes performed seoi-nage. No significant difference was found in motion phase time of the turning phase between the two groups, indicating that motion phase time is not necessarily a factor contributing quickness in seoi-nage...
February 24, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28631616/on-the-dynamics-of-perching-manoeuvres-with-low-aspect-ratio-planforms
#18
J N Fernando, D E Rival
The dynamics of a simple perching manoeuvre are investigated using circular and aspect-ratio-two elliptical flat plates, as abstractions of low-aspect-ratio planforms observed in highly-manoeuvrable birds. The perching kinematic investigated in this study involves a pitch-up motion from an angle of attack of [Formula: see text] to [Formula: see text], while simultaneously decelerating. This motion is defined by the shape change number, [Formula: see text], which acts as a measure of the relative contributions of added-mass and circulatory effects...
June 20, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28631166/morphology-and-the-gradient-of-a-symmetric-potential-predict-gait-transitions-of-dogs
#19
Simon Wilshin, G Clark Haynes, Jack Porteous, Daniel Koditschek, Shai Revzen, Andrew J Spence
Gaits and gait transitions play a central role in the movement of animals. Symmetry is thought to govern the structure of the nervous system, and constrain the limb motions of quadrupeds. We quantify the symmetry of dog gaits with respect to combinations of bilateral, fore-aft, and spatio-temporal symmetry groups. We tested the ability of symmetries to model motion capture data of dogs walking, trotting and transitioning between those gaits. Fully symmetric models performed comparably to asymmetric with only a [Formula: see text] increase in the residual sum of squares and only one-quarter of the parameters...
June 19, 2017: Biological Cybernetics
https://www.readbyqxmd.com/read/28630833/anti-inflammatory-prophylaxis-prevents-heterotopic-ossification-in-contralateral-side-hip-arthroscopy-a-case-report
#20
Yaniv Warschawski, Zachary T Sharfman, Eyal Amar, Ehud Rath
INTRODUCTION: Heterotopic ossification (HO) after hip surgery is the formation of bone in non-skeletal tissue, usually between the muscle and the joint capsule. HO after hip surgery may be associated with clinical sequelae such as pain, impingement and decreased range of motion, compromising surgical outcomes. CASE REPORT: A 20-year-old basketball player presented with a 2-year duration of the left groin pain after a basketball-related injury. Due to continued disability and failure of conservative management the patient underwent hip arthroscopy...
January 2017: Journal of Orthopaedic Case Reports
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