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https://www.readbyqxmd.com/read/28188652/water-temperature-and-dietary-histidine-affect-cataract-formation-in-atlantic-salmon-salmo-salar-l-diploid-and-triploid-yearling-smolt
#1
F Sambraus, P G Fjelldal, S C Remø, E M Hevrøy, T O Nilsen, A Thorsen, T J Hansen, R Waagbø
The aim of the present study was to investigate cataract development in diploid (2N) and triploid (3N) Atlantic salmon smolts and post-smolts at two water temperatures (10 and 16 °C) given diets with different histidine supplementation (LH, 10.4 and HH, 13.1 g kg(-1) ) before and after seawater transfer. In freshwater, a severe cataract outbreak was recorded in both ploidies reared at 16 °C. The cataract score was significantly higher in triploids compared to diploids, and the severity was lower in both ploidies fed the HH diet...
February 11, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28123157/olive-and-ginkgo-extracts-as-potential-cataract-therapy-with-differential-inhibitory-activity-on-aldose-reductase
#2
Diaaeldin Mohamed Abdelkawi Elimam, Ahmed Salah Uddin Ibrahim, Gregory Ing Liou, Farid Abd-Elrehim Abd-Elaziz Badria
Aldose reductase (AR) has been the leading target in the treatment of diabetic cataract. Although numerous synthetic AR inhibitors (ARI) have been identified, their adverse side effects currently preclude their use. Olive leaf extract (OLE) as well as ginkgo leaf extract (GLE) are natural supplements that have wide therapeutic indices and a plethora of salutary effects during diabetes that so far untested on sugar cataract progression. As such, the present study sought to evaluate the AR-inhibiting properties of OLE and GLE using the isolated enzyme from rabbit lens...
January 26, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28056318/-clinical-characteristics-of-adult-onset-primary-hypoparathyroidism-a-retrospective-analysis-of-200-cases
#3
T T Quan, Y P Li, O Wang, Y Jiang, W B Xia, M Li, X Q Cheng, X W Meng, X P Xing
Objective: To study the clinical characteristics of primary hypoparathyroidism in adults. Methods: The clinical data of 200 cases with adult-onset primary hypoparathyroidism in Peking Union Medical College Hospital during December 1987 to December 2015 were collected and analyzed retrospectively. Among them, 128 cases were followed up for a median period of 3 years. Results: The major manifestations at their first visits were tetany and numbness in the distal extremities(81.5%, 163/200 and 62.0%, 124/200). Thirty-two percent of the cases (62 cases) had history of seizures, and 60...
January 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27982689/the-effect-of-laurus-nobilis-on-the-blood-and-lenses-antioxidant-activity-in-rabbit-under-fat-enriched-diet
#4
D Casamassima, F Chiosi, F Vizzarri, M Palazzo, C Costagliola
Fat-enriched diet is strongly associated with cataract development. Laurus nobilis shows antioxidant activity. Herein we evaluated the effect of Laurus nobilis oral administration on the blood and lenses antioxidant activity in rabbits under fat-enriched-diet. Sixty rabbits divided into 4 groups were used. One group represented the control (N-CTR). The second group (P-CTR) fed a diet supplemented with 2.5% of pig fat; the third group (EXP1) received a diet supplemented with 2.5% of pig fat and 1 g/kg of dried-bay leaves; the fourth group (EXP2) was treated with dried-bay leaves at the rate of 1 g/kg of feed...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27752786/selenite-and-ebselen-supplementation-attenuates-d-galactose-induced-oxidative-stress-and-increases-expression-of-selr-and-sep15-in-rat-lens
#5
Jie Dai, Jun Zhou, Hongmei Liu, Kaixun Huang
Selenite and ebselen supplementation has been shown to possess anti-cataract potential in some experimental animal models of cataract, however, the underlying mechanisms remain unclear. The present study was designed to evaluate the anti-cataract effects and the underlying mechanisms of selenite and ebselen supplementation on galactose induced cataract in rats, a common animal model of sugar cataract. Transmission electron microscopy images of lens fiber cells (LFC) and lens epithelial cells (LEC) were observed in D-galactose-induced experimental cataractous rats treated with or without selenite and ebselen, also redox homeostasis and expression of proteins such as selenoprotein R (SELR), 15kD selenoprotein (SEP15), superoxide dismutase 1 (SOD1), catalase (CAT), β-crystallin protein, aldose reductase (AR) and glucose-regulated protein 78 (GRP78) were estimated in the lenses...
October 17, 2016: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/27728893/magnesium-taurate-prevents-cataractogenesis-via-restoration-of-lenticular-oxidative-damage-and-atpase-function-in-cadmium-chloride-induced-hypertensive-experimental-animals
#6
Rajesh Choudhary, Surendra H Bodakhe
Previously we found that hypertension potentiates the risk the cataractogenesis. In the present study, we investigated the protective effects of magnesium taurate (MgT) on hypertension and associated lenticular damages against cadmium chloride (CdCl2)-induced hypertensive animals. Male Sprague-Dawley albino rats (150-180g) were assigned to five experimental groups (n=6). Among the five groups, normal group received 0.3% carboxymethyl cellulose (10ml/kg/day, p.o.). Hypertension control group received CdCl2 (0...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27703849/atlantic-salmon-salmo-salar-require-increased-dietary-levels-of-b-vitamins-when-fed-diets-with-high-inclusion-of-plant-based-ingredients
#7
Gro-Ingunn Hemre, Erik-Jan Lock, Pål Asgeir Olsvik, Kristin Hamre, Marit Espe, Bente Elisabeth Torstensen, Joana Silva, Ann-Cecilie Hansen, Rune Waagbø, Johan S Johansen, Monica Sanden, Nini H Sissener
Aiming to re-evaluate current recommendations for nutrient supplementations when Atlantic salmon are fed diets based on plant ingredients, two regression experiments, with parr and post-smolt, were conducted. A control diet was included to evaluate if ingredients supplied sufficient nutrients without any added nutrient package (NP). The nutrient package consisted of vitamins B, C, E, minerals, cholesterol, methionine, taurine and histidine. This paper focus on B-vitamins. In parr, growth, health and welfare parameters responded on NP additions, but this was not observed in the seawater stage...
2016: PeerJ
https://www.readbyqxmd.com/read/27685794/in-vitro-and-in-vivo-inhibition-of-aldose-reductase-and-advanced-glycation-end-products-by-phloretin-epigallocatechin-3-gallate-and-6-gingerol
#8
Chethan Sampath, Shengmin Sang, Mohamed Ahmedna
Hyperglycemic stress activates polyol pathway and aldose reductase (AR) key enzyme responsible for generating secondary complications during diabetes. In this study the therapeutic potential of phloretin, epigallocatechin 3-gallate (EGCG) and [6]-gingerol were evaluated for anti-glycating and AR inhibitory activity in vitro and in vivo systems. Human retinal pigment epithelial (HRPE) cells were induced with high glucose supplemented with the phloretin, EGCG and [6]-gingerol. Aldose reductase activity, total advanced glycation end products (AGEs) and enzyme inhibitor kinetics were assessed...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27639366/design-and-synthesis-of-chiral-2h-chromene-n-imidazolo-amino-acid-conjugates-as-aldose-reductase-inhibitors
#9
Gudipudi Gopinath, Venu Sankeshi, Shaym Perugu, Malini D Alaparthi, Srinivas Bandaru, Vijay K Pasala, Prasad Rao Chittineni, G L David Krupadanam, Someswar R Sagurthi
Aldose reductase (ALR2) inhibitors provide a viable mode to fight against diabetic complications. ALR2 exhibit plasticity in the active site vicinities and possible shifts in the nearby two supporting alpha helices. Therefore, a novel series of amino acid conjugates of chromene-3-imidazoles (13-15) were designed and synthesized based on natural isoflavonoids. The compounds were identified on the basis of spectral ((1)H NMR, (13)C NMR and MS) data and tested in vitro for ALR2 inhibitory activity with an IC50 value ranges from 0...
November 29, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27479624/vision-loss-in-older-adults
#10
Allen L Pelletier, Ledy Rojas-Roldan, Janis Coffin
Vision loss affects 37 million Americans older than 50 years and one in four who are older than 80 years. The U.S. Preventive Services Task Force concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for impaired visual acuity in adults older than 65 years. However, family physicians play a critical role in identifying persons who are at risk of vision loss, counseling patients, and referring patients for disease-specific treatment. The conditions that cause most cases of vision loss in older patients are age-related macular degeneration, glaucoma, ocular complications of diabetes mellitus, and age-related cataracts...
August 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27277218/differentiation-of-severe-bilateral-panuveitis-following-phacoemulsification-a-case-report
#11
Xi Peng, Junjun Zhang
BACKGROUND: Cataract surgery typically offers instant visual rehabilitation with rare postoperative complications. However, if complications occur, these complications may be confusing and threatening. We present a case of severe bilateral panuveitis following phacoemulsification and intraocular lens implantation and discuss the importance of a correct diagnosis and management. CASE PRESENTATION: A 75-year-old Asian male with bilateral phacoemulsification and intraocular lens implantation developed severe inflammation with sharp vision loss in both eyes after the surgeries...
June 8, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27211876/assessing-resident-cataract-surgery-outcomes-using-medicare-physician-quality-reporting-system-measures
#12
Avni P Finn, Sheila Borboli-Gerogiannis, Stacey Brauner, Han-Ying Peggy Chang, Sherleen Chen, Matthew Gardiner, Scott H Greenstein, Carolyn Kloek, Joan W Miller, Teresa C Chen
OBJECTIVES: To assess resident cataract surgery outcomes at an academic teaching institution using 2 Physician Quality Reporting System (PQRS) cataract measures, which are intended to serve as a proxy for quality of surgical care. DESIGN: A retrospective review comparing cataract surgery outcomes of resident and attending surgeries using 2 PQRS measures: (1) 20/40 or better best-corrected visual acuity following cataract surgery and (2) complications within 30 days following cataract surgery requiring additional surgical procedures...
September 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27150288/dietary-supplements-and-disease-prevention-a-global-overview
#13
REVIEW
Susanne Rautiainen, JoAnn E Manson, Alice H Lichtenstein, Howard D Sesso
Dietary supplements are widely used and offer the potential to improve health if appropriately targeted to those in need. Inadequate nutrition and micronutrient deficiencies are prevalent conditions that adversely affect global health. Although improvements in diet quality are essential to address these issues, dietary supplements and/or food fortification could help meet requirements for individuals at risk of deficiencies. For example, supplementation with vitamin A and iron in developing countries, where women of reproductive age, infants and children often have deficiencies; with folic acid among women of reproductive age and during pregnancy; with vitamin D among infants and children; and with calcium and vitamin D to ensure bone health among adults aged ≥65 years...
July 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27091854/relationship-between-macular-pigment-and-visual-function-in-subjects-with-early-age-related-macular-degeneration
#14
Kwadwo Owusu Akuffo, John M Nolan, Tunde Peto, Jim Stack, Irene Leung, Laura Corcoran, Stephen Beatty
PURPOSE: To investigate the relationship between macular pigment (MP) and visual function in subjects with early age-related macular degeneration (AMD). METHODS: 121 subjects with early AMD enrolled as part of the Central Retinal Enrichment Supplementation Trial (CREST; ISRCTN13894787) were assessed using a range of psychophysical measures of visual function, including best corrected visual acuity (BCVA), letter contrast sensitivity (CS), mesopic and photopic CS, mesopic and photopic glare disability (GD), photostress recovery time (PRT), reading performance and subjective visual function, using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25)...
April 18, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27037095/effect-of-polysaccharide-from-bacillus-subtilis-sp-on-cardiovascular-diseases-and-atherogenic-indices-in-diabetic-rats
#15
Mona A M Ghoneim, Amal I Hassan, Manal G Mahmoud, Mohsen S Asker
BACKGROUND: Diabetes mellitus induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy, and polyneuropathy. The main aim of the study was to isolate and identify both of bacterial strain and exopolysaccharide to assess the possible efficiency of exopolysaccharide (BSEPS) from Bacillus subtilus sp .suppress on cardiovascular diseases, atherogenic and coronary risk indices in diabetic rats. METHODS: The bacterial strain used was isolated from mangrove tree sediment by serial dilution and the spread-plate technique and identified by morphological, physiological, and biochemical characteristics, and by 16S rRNA analysis...
March 31, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27016950/genetic-and-dietary-factors-influencing-the-progression-of-nuclear-cataract
#16
Ekaterina Yonova-Doing, Zoe A Forkin, Pirro G Hysi, Katie M Williams, Tim D Spector, Clare E Gilbert, Christopher J Hammond
PURPOSE: To determine the heritability of nuclear cataract progression and to explore prospectively the effect of dietary micronutrients on the progression of nuclear cataract. DESIGN: Prospective cohort study. PARTICIPANTS: Cross-sectional nuclear cataract and dietary measurements were available for 2054 white female twins from the TwinsUK cohort. Follow-up cataract measurements were available for 324 of the twins (151 monozygotic and 173 dizygotic twins)...
June 2016: Ophthalmology
https://www.readbyqxmd.com/read/26948785/effect-of-a-multimedia-assisted-informed-consent-procedure-on-the-information-gain-satisfaction-and-anxiety-of-cataract-surgery-patients
#17
RANDOMIZED CONTROLLED TRIAL
Saskia M Tipotsch-Maca, Ralph M Varsits, Christian Ginzel, Pia V Vecsei-Marlovits
PURPOSE: To assess whether a multimedia-assisted preoperative informed consent procedure has an effect on patients' knowledge concerning cataract surgery, satisfaction with the informed consent process, and reduction in anxiety levels. SETTING: Hietzing Hospital, Vienna, Austria. DESIGN: Prospective randomized controlled clinical trial. METHODS: Patients participated in an informed consent procedure for age-related cataract surgery that included the standard approach only (reading the information brochure and having a standardized face-to-face discussion) or supplemented with a computer-animated video...
January 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26903189/an-eye-on-nutrition-the-role-of-vitamins-essential-fatty-acids-and-antioxidants-in-age-related-macular-degeneration-dry-eye-syndrome-and-cataract
#18
Meagen M McCusker, Khayyam Durrani, Michael J Payette, Jeanine Suchecki
Visual impairment is a global epidemic. In developing countries, nutritional deficiency and cataracts continue to be the leading cause of blindness, whereas age-related macular degeneration (AMD) and cataracts are the leading causes in developed nations. The World Health Organization has instituted VISION 2020: "The Right to Sight" as a global mission to put an end to worldwide blindness. In industrialized societies, patients, physicians, researchers, nutritionists, and biochemists have been looking toward vitamins and nutrients to prevent AMD, cataracts, and dry eye syndrome (DES)...
March 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/26872132/thymoquinone-rescues-t-lymphocytes-from-gamma-irradiation-induced-apoptosis-and-exhaustion-by-modulating-pro-inflammatory-cytokine-levels-and-pd-1-bax-and-bcl-2-signaling
#19
Mona Samy Guida, Ali Abd El-Aal, Yehya Kafafy, Safwat Farid Salama, Badr Mohamed Badr, Gamal Badr
BACKGROUND/AIMS: Recent studies have shown that thymoquinone (TQ) exerts protective effects against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats. Nevertheless, there is no published work investigated the effects of TQ on T cell development and biology in animal models exposed to gamma radiation. Therefore, in the present study we focused on determining the effects of TQ on radiation damage in the thymus, radiation-induced T cell imbalance, and on immune dysfunction induced by gamma-rays...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26856427/correlational-analysis-of-objective-and-subjective-measures-of-cataract-quantification
#20
MULTICENTER STUDY
Béatrice Cochener, Sunni R Patel, Florence Galliot
PURPOSE: To evaluate whether correlations exist between objective and subjective measures of vision quality as a consequence of cataract and whether this may qualify the Objective Scatter Index as a supplementary means of cataract assessment. METHODS: A prospective multicenter, cross-sectional study was conducted in 10 centers across France in patients undergoing cataract extraction surgery (lens opacity evaluated with the Lens Opacities Classification System III)...
February 2016: Journal of Refractive Surgery
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