keyword
https://read.qxmd.com/read/38445144/antimicrobial-activity-of-zinc-oxide-nanoparticles-synthesized-using-ocimum-tenuiflorum-and-ocimum-gratissimum-herbal-formulation-against-oral-pathogens
#21
JOURNAL ARTICLE
Remmiya Mary Varghese, Aravind Kumar S, Rajeshkumar Shanmugam
Background This study deals with the antimicrobial efficacy of zinc oxide nanoparticles (ZnONPs) synthesized through green methods employing extracts from Ocimum tenuiflorum and Ocimum gratissimum  and assessed for their antimicrobial properties against a range of oral pathogens. Methods Zinc oxide nanoparticles (ZnONPs) were synthesized using extracts from Ocimum tenuiflorum  and Ocimum gratissimum  through a green synthesis approach. Antimicrobial activity was determined using the agar-well diffusion assay to evaluate the consistency of inhibition zones against oral pathogens...
February 2024: Curēus
https://read.qxmd.com/read/38440286/genetic-characterization-of-glyoxalase-pathway-in-oral-streptococci-and-its-contribution-to-interbacterial-competition
#22
JOURNAL ARTICLE
Lin Zeng, Payam Noeparvar, Robert A Burne, Benjamin S Glezer
OBJECTIVES: To analyze contributions to microbial ecology of Reactive Electrophile Species (RES), including methylglyoxal, generated during glycolysis. METHODS: Genetic analyses were performed on the glyoxalase pathway in Streptococcus mutans (SM) and Streptococcus sanguinis (SS), followed by phenotypic assays and transcription analysis. RESULTS: Deleting glyoxalase I (lguL) reduced RES tolerance to a far greater extent in SM than in SS, decreasing the competitiveness of SM against SS...
2024: Journal of Oral Microbiology
https://read.qxmd.com/read/38440002/miswak-infused-glass-ionomer-cement-a-comparative-in-vitro-analysis-of-antibacterial-efficacy-and-compressive-strength
#23
JOURNAL ARTICLE
Kamala Devi, Jessy Paulraj, Rajeshkumar Shanmugam, Subhabrata Maiti
BACKGROUND: Glass ionomer cement (GIC) restorations are commonly used in primary dentition, due to their aesthetic appeal, self-adhesive nature, and biocompatibility. However, the material's limited antibacterial activity and inadequate mechanical strength highlight the necessity for modifying the material. AIM: The study aims to evaluate and compare the antimicrobial potency and compressive strength of GIC-incorporated Miswak extract with that of conventional GIC...
February 2024: Curēus
https://read.qxmd.com/read/38435891/assessment-of-antimicrobial-activity-of-nanocomposites-based-on-nano-hydroxyapatite-hap-chitosan-and-vitamin-k2
#24
JOURNAL ARTICLE
Revathi Duraisamy, Dhanraj Ganapathy, Rajeshkumar Shanmugam, Ezhilarasan Devaraj, Amrutha Shenoy
OBJECTIVE: The objective of this study was to evaluate the antimicrobial potential of nanocomposites containing vitamin K2, hydroxyapatite nanoparticles (nHAP), and chitosan (Chito)-coated dental implants against clinically relevant microbial strains. MATERIALS AND METHODS: Four test compounds were prepared: vitamin K2 + nHAP, K2 + Chito + nHAP, vitamin K2, and vitamin K2 + Chito. Agar well diffusion test was conducted to assess the antimicrobial activity of these compounds against Staphylococcus aureus (S...
January 2024: Curēus
https://read.qxmd.com/read/38433291/antibacterial-coating-of-orthodontic-elastomeric-ligatures-with-silver-and-bismuth-nanofilms-by-magnetron-sputtering-%C3%A2-a%C3%A2-feasibility-study
#25
JOURNAL ARTICLE
Andrea Schubert, Carolin Griesmüller, Nikolaus Gersdorff, Ralf Bürgers, Bernhard Wiechens, Torsten Wassmann
OBJECTIVES: Magnetron sputtering was evaluated to equip surfaces of orthodontic elastomeric ligatures with silver and bismuth nanofilms. MATERIAL AND METHODS: Antibacterial properties were evaluated by the adhesion of Streptococcus mutans. Polyurethane-based elastomeric ligatures were coated with silver and bismuth nanofilms via direct current magnetron sputtering. Surface roughness (Ra ) and surface-free energy (SFE) were assessed. Coated specimens were incubated with S...
April 2024: Clinical and Experimental Dental Research
https://read.qxmd.com/read/38431610/inhibitory-and-preventive-effects-of-arnebia-euchroma-royle-johnst-root-extract-on-streptococcus-mutans-and-dental-caries-in-rats
#26
JOURNAL ARTICLE
Zeyu Wu, Jie Song, Yangyang Zhang, Xiyu Yuan, Jin Zhao
BACKGROUND: Dental caries is one of the prevalent conditions that threaten oral health. Arnebia euchroma (Royle) Johnst. root (AR) extracts exhibit anti-inflammatory, anti-cancer, and antibacterial properties. This study was designed to investigate the antibacterial impact of AR extract on Streptococcus mutans (S. mutans) UA159 and the anti-caries effect on rats. METHODS: The antibacterial activity of AR extract against S. mutans and its biofilm was determined using the bacterial sensitivity test, the biofilm sensitivity test, and the live-dead staining technique...
March 2, 2024: BDJ Open
https://read.qxmd.com/read/38425324/antimicrobial-properties-of-glass-ionomer-cement-incorporated-with-nano-hydroxyapatite-against-mutans-streptococci-and-lactobacilli-under-orthodontic-bands-an-in-vivo-split-mouth-study
#27
JOURNAL ARTICLE
Maryam Shirazi, Aydin Pirzeh, Marzieh Atashgaran
BACKGROUND: Fixed orthodontic appliances enhance dental plaque accumulation. Glass ionomer (GI) is among the most popular orthodontic cement. It possesses antibacterial properties; however, its antibacterial activity may not be sufficient for caries prevention. Although evidence shows that the addition of 8wt% nano-hydroxyapatite (nHA) may enhance the antibacterial properties of GI, no clinical study has been conducted in this respect. Thus, this study aimed to assess the subgingival accumulation of Streptococcus mutans (S...
2024: Dental Research Journal
https://read.qxmd.com/read/38425046/flavonoids-effects-against-bacteria-associated-to-periodontal-disease-and-dental-caries-a-scoping-review
#28
REVIEW
Bruna Tavares Carneiro, Fernanda Novais Arantes Maciel de Castro, Francine Benetti, Gabriel Nima, Thais Yumi Umeda Suzuki, Carolina Bosso André
This scoping review focused on exploring the efficacy of flavonoids against bacteria associated with dental caries and periodontal diseases. Inclusion criteria comprise studies investigating the antibacterial effects of flavonoids against bacteria linked to caries or periodontal diseases, both pure or diluted in vehicle forms. The search, conducted in August 2023, in databases including PubMed/MEDLINE, Scopus, Web of Science, Embase, LILACS, and Gray Literature. Out of the initial 1125 studies, 79 met the inclusion criteria, majority in vitro studies...
February 29, 2024: Biofouling
https://read.qxmd.com/read/38414799/microbiome-friendly-ps-pvp-electrospun-fibrous-membrane-with-antibiofilm-properties-for-dental-engineering
#29
JOURNAL ARTICLE
Jiamin Chen, Jia Guo, Xueyun Lu, Derong Yin, Cuisong Zhou, Yuqing Li, Xuedong Zhou
Dental caries is one of the most prevalent and biofilm-associated oral diseases in humans. Streptococcus mutans , with a high ability to form biofilms by adhering to hard surfaces, has been established as an important etiological agent for dental caries. Therefore, it is crucial to find a way to prevent the formation of cariogenic biofilm. Here, we report an electrospun fibrous membrane that could inhibit the adhesion and biofilm formation of S. mutans . Also, the polystyrene (PS)/polyvinyl pyrrolidone (PVP) electrospun fibrous membrane altered the 3D biofilm architecture and decreased water-insoluble extracellular polysaccharide production...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38414694/evaluation-of-antibacterial-and-anti-oxidant-activities-of-suaeda-monoica-extract-for-its-potential-application
#30
JOURNAL ARTICLE
Akitha Shakthi, Joseph Linoj, Vasugi Suresh, Mohammed Asif Hussein, Muthamizh Selvamani
BACKGROUND:  An assessment of Suaeda monoica extract's antimicrobial and antioxidant properties was undertaken in light of its possible application as an oral care product. The maintenance of optimal dental health is just as important as overall wellness. Food particles become trapped in the mouth cavity, making it easy for oral bacteria to infect. AIM:  The study sought to ascertain the antibacterial and antioxidant properties of salt marsh Suaeda monoica extract...
January 2024: Curēus
https://read.qxmd.com/read/38414676/comparison-of-the-antibacterial-efficacy-of-bamboo-shoot-ethanol-extract-with-chlorhexidine-mouth-rinse-against-salivary-streptococcus-mutans-and-lactobacillus-acidophilus-an-ex-vivo-study
#31
JOURNAL ARTICLE
Divya Bharathi S, Priya Deepa Lakshmi K, Gunasekaran M, Venkata Lakshmi S, Anjali Reji, Kathija Sulthana F
Background Dental caries is the most prevalent polymicrobial oral infectious disease tormenting individuals' healthy lifestyles and presents a significant public health problem. The objective of this study was to evaluate and compare the antibacterial properties of different concentrations of bamboo shoot ethanol extract with chlorhexidine mouth rinse on isolates of salivary Streptococcus mutans ( S. mutans ) and Lactobacillus acidophilus ( L. acidophilus ) . Materials and methods Non-stimulated salivary samples from 30 young adults were treated ex vivo with bamboo shoot ethanolic extract at concentrations of 30 µg/ml, 40 µg/ml, 50 µg/ml, and 60 µg/ml...
January 2024: Curēus
https://read.qxmd.com/read/38411065/opposing-genetic-polymorphisms-of-two-abc-transporters-contribute-to-the-variation-of-nukacin-resistance-in-streptococcus-mutans
#32
JOURNAL ARTICLE
Naoki Sadaoka, Mi Nguyen-Tra Le, Miki Kawada-Matsuo, Sopongselamuny Eng, Takeshi Zendo, Jun Nakanishi, Katsuhiro Takeda, Hideki Shiba, Hitoshi Komatsuzawa
Streptococcus mutans is a cariogenic bacterium that produces a variety of bacteriocins and retains resistance to these bacteriocins. In this study, we investigated the susceptibility of 127 S . mutans strains to nukacins produced by Staphylococcus spp., which are commensal bacteria in humans. We detected diverse susceptibilities among strains. Nineteen strains had a disrupted LctF (type I), which is responsible for nukacin susceptibility, whereas the remaining 108 strains had an intact LctF (type II) and displayed resistance to nukacins...
February 27, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38407541/synthesis-antimicrobial-activities-and-%C3%A2-molecular-modeling-studies-of-agents-for-the-sortase-a-enzyme
#33
JOURNAL ARTICLE
Gizem Tatar Yilmaz, Nurettin Yayli, Tamer Tüzüner, Gözde Bozdal, Merve Salmanli, Gülin Renda, Büşra Korkmaz, Arif Bozdeveci, Şengül Alpay Karaoğlu
Sortase A (SrtA) is an attractive target for developing new anti-infective drugs that aim to interfere with essential virulence mechanisms, such as adhesion to host cells and biofilm formation. Herein, twenty hydroxy, nitro, bromo, fluoro, and methoxy substituted chalcone compounds T1-20 were synthesized, antimicrobial activities and molecular modeling strategies against the SrtA enzyme were investigated. The most active compounds were found to be T2, T4, and T19 against Streptococcus mutans (S. mutans) with the MIC values; 1...
February 26, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38406557/fluoride-releasing-in-polymer-blends-of-poly-ethylene-oxide-and-poly-methyl-methacrylate
#34
JOURNAL ARTICLE
Tianxiao Wang, Menghong Li, Ziyan Gu, Chengjuan Qu, Jonas Segervald, Roushdey Salh, Thomas Wågberg, Jia Wang, Wen Kou
Introduction: Polymethyl methacrylate is a polymer commonly used in clinical dentistry, including denture bases, occlusal splints and orthodontic retainers. Methods: To augment the polymethyl methacrylate-based dental appliances in counteracting dental caries, we designed a polymer blend film composed of polymethyl methacrylate and polyethylene oxide by solution casting and added sodium fluoride. Results: Polyethylene oxide facilitated the dispersion of sodium fluoride, decreased the surface average roughness, and positively influenced the hydrophilicity of the films...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38405599/oxidative-stress-response-a-critical-factor-affecting-the-ecological-competitiveness-of-streptococcus-mutans
#35
REVIEW
Xingqun Cheng, Xin Xu, Xuedong Zhou, Jia Ning
Oral microecological balance is closely associated with the development of dental caries. Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community. Streptococcus mutans is linked to the occurrence and development of dental caries. The ability of S. mutans to withstand oxidative stress affects its survival competitiveness in biofilms. The oxidative stress regulatory mechanisms of S. mutans include synthesis of reductase, regulation of metal ions uptake, regulator PerR, transcription regulator Spx, extracellular uptake of glutathione, and other related signal transduction systems...
2024: Journal of Oral Microbiology
https://read.qxmd.com/read/38402755/rapid-multiplex-real-time-pcr-assay-using-a-portable-device-for-the-detection-of-oral-pathogens
#36
JOURNAL ARTICLE
Wit Yee Wint, Mayu Miyanohara, Hidenori Yamada, Takako Nakatsuka, Masaaki Okamoto, Koufuchi Ryo, Tomoko Tanaka, Nobuhiro Hanada, Takatoshi Murata
Colonization by several oral pathogens and the onset of oral diseases, such as dental caries and periodontal diseases, are closely related. Therefore, the analysis of pathogens in oral specimens would be helpful for the risk assessment of oral diseases. We developed a rapid multiplex real-time polymerase chain reaction (PCR) method using a portable device and newly designed probe/primer sets to detect the oral pathogens Streptococcus mutans, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia...
February 15, 2024: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/38399269/anti-cariogenic-effects-of-s-cerevisiae-and-s-boulardii-in-s-mutans-c-albicans-cross-kingdom-in-vitro-models
#37
JOURNAL ARTICLE
Dina Yousif, Yan Wu, Alexandria Azul Gonzales, Christa Mathieu, Yan Zeng, Lee Sample, Sabrina Terando, Ting Li, Jin Xiao
Despite the well-documented health benefits of the probiotic Saccharomyces , its application in oral health has not been comprehensively assessed. Dental caries is a transmissible disease initiated by acid production of cariogenic bacteria and yeast, such as Streptococcus mutans and Candida albicans , on tooth enamel and followed by subsequent enamel demineralization. Here, we investigated the effect of two Saccharomyces strains ( Saccharomyces boulardii and Saccharomyces cerevisiae ) on S. mutans - C. albicans cross-kingdom interactions using a cariogenic planktonic model...
February 1, 2024: Pharmaceutics
https://read.qxmd.com/read/38399151/development-of-antibacterial-resin-composites-incorporating-poly-metac-clusters
#38
JOURNAL ARTICLE
Tomoki Kohno, Haruaki Kitagawa, Ririko Tsuboi, Fan Deng, Hirohiko Sakai, Tingyi Wu, Yo-Shiuan Fan, Linghao Xiao, Satoshi Imazato
This study examined the antibacterial effects and physical properties of a novel resin composite incorporating poly[{2-(methacryloyloxy)ethyl}trimethylammonium chloride] (poly(METAC)), a methacrylate cationic polymer comprising quaternary ammonium compounds (QACs). Resin composites incorporating poly(METAC) were fabricated by adding 6 wt.% METAC aqueous solution to a commercially available resin composite. The FE-SEM/EDS and Raman spec-troscopy analyses showed that METAC was assembled and polymerized in the resin composites after curing...
February 15, 2024: Materials
https://read.qxmd.com/read/38398630/antibacterial-activity-of-plant-polyphenols-belonging-to-the-tannins-against-streptococcus-mutans-potential-against-dental-caries
#39
JOURNAL ARTICLE
Krzysztof Czerkas, Ewa Olchowik-Grabarek, Magdalena Łomanowska, Nodira Abdulladjanova, Szymon Sękowski
Dental caries (DC) is the most common oral pathology. The main bacteria responsible for DC is Streptococcus mutans . One of the strategies that can decrease or eliminate the risk of DC development is using compounds that will inhibit both the growth and virulence factors of S. mutans . Tannins are plant polyphenols that have strong antibacterial activity. The purpose of this study was to assess the antibacterial activity of three tannins against S. mutans. In this investigation, microbiological tests (MIC and MBC) and physicochemical techniques like the fluorescence measurements of tannins' interaction with S...
February 16, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38395246/antimicrobial-photodynamic-therapy-against-a-dual-species-cariogenic-biofilm-using-a-ruthenium-loaded-resin-based-dental-material
#40
JOURNAL ARTICLE
Maria Luísa Leite, Patricia Comeau, Sana Aghakeshmiri, Dirk Lange, Lidiany Karla Azevedo Rodrigues, Neil Branda, Adriana Pigozzo Manso
BACKGROUND: Streptococcus mutans and Candida albicans are associated with caries recurrence. Therefore, this study evaluated the combination of a Ru(II)-loaded resin-based dental material (RDM) and antimicrobial photodynamic therapy (aPDT) against a dual-species biofilm of S. mutans and C. albicans. METHODS: An aPDT protocol was established evaluating Ru(II)'s photocatalytic activity and antimicrobial potential under blue LED irradiation (440-460 nm, 22.55 mW/cm2 ) at different energy densities (0...
February 21, 2024: Photodiagnosis and Photodynamic Therapy
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