Gizem Tatar Yilmaz, Nurettin Yayli, Tamer Tüzüner, Gözde Bozdal, Merve Salmanli, Gülin Renda, Büşra Korkmaz, Arif Bozdeveci, Şengül Alpay Karaoğlu
Sortase A (SrtA) is an attractive target for developing new anti-infective drugs that aim to interfere with essential virulence mechanisms, such as adhesion to host cells and biofilm formation. Herein, twenty hydroxy, nitro, bromo, fluoro, and methoxy substituted chalcone compounds T1-20 were synthesized, antimicrobial activities and molecular modeling strategies against the SrtA enzyme were investigated. The most active compounds were found to be T2, T4, and T19 against Streptococcus mutans (S. mutans) with the MIC values; 1...
February 26, 2024: Chemistry & Biodiversity