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Streptococcus mutans

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https://www.readbyqxmd.com/read/28719833/in-silico-search-of-inhibitors-of-streptococcus-mutans-for-the-control-of-dental-plaque
#1
Rodrigo Ochoa, María Cecilia Martínez-Pabón, María Adelaida Arismendi-Echeverri, Willer Leandro Rendón-Osorio, Carlos Enrique Muskus-López
Biofilm is an extremely complex microbial community arranged in a matrix of polysaccharides and attached to a substrate. Its development is crucial in the pathophysiology of oral infections like dental caries, as well as in periodontal, pulp, and periapical diseases. Streptococcus mutans is one of the most effective microorganisms in lactic acid production of the dental biofilm. Identifying essential Streptococcus mutans proteins using bioinformatics methods helps to search for alternative therapies. To this end, the bacterial genomes of several Streptococcus mutans strains and representative strains of other cariogenic and non-cariogenic bacteria were analysed by identifying pathogenicity islands and alignments with other bacteria, and by detecting the exclusive genes of cariogenic species in comparison to the non-pathogenic ones...
July 1, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28717847/exploring-the-genomic-diversity-and-cariogenic-differences-of-streptococcus-mutans-strains-through-pan-genome-and-comparative-genome-analysis
#2
Peiqi Meng, Chang Lu, Qian Zhang, Jiuxiang Lin, Feng Chen
Pan-genome refers to the sum of genes that can be found in a given bacterial species, including the core-genome and the dispensable genome. In this study, the genomes from 183 Streptococcus mutans (S. mutans) isolates were analyzed from the pan-genome perspective. This analysis revealed that S. mutans has an "open" pan-genome, implying that there are plenty of new genes to be found as more genomes are sequenced. Additionally, S. mutans has a limited core-genome, which is composed of genes related to vital activities within the bacterium, such as metabolism and hereditary information storage or processing, occupying 35...
July 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28717846/effects-of-xylitol-and-sucrose-mint-products-on-streptococcus-mutans-colonization-in-a-dental-simulator-model
#3
Krista M Salli, Ulvi K Gürsoy, Eva M Söderling, Arthur C Ouwehand
Few laboratory methods exist for evaluating the cariogenicity of food ingredients. In this study, a dental simulator was used to determine the effects of commercial sucrose and xylitol mint products on the adherence and planktonic growth of Streptococcus mutans. Solutions (3% w/v) of sucrose, xylitol, sucrose mints, xylitol mints, xylitol with 0.02% peppermint oil (PO), and 0.02% PO alone were used to test the levels of planktonic and adhered S. mutans. A dental simulator with continuous artificial saliva flow, constant temperature, and mixing was used as a test environment and hydroxyapatite (HA) discs were implemented into the model to simulate the tooth surface...
July 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28715508/biofilm-extracellular-polysaccharides-degradation-during-starvation-and-enamel-demineralization
#4
Bárbara Emanoele Costa Oliveira, Jaime Aparecido Cury, Antônio Pedro Ricomini Filho
This study was conducted to evaluate if extracellular polysaccharides (EPS) are used by Streptococcus mutans (Sm) biofilm during night starvation, contributing to enamel demineralization increasing occurred during daily sugar exposure. Sm biofilms were formed during 5 days on bovine enamel slabs of known surface hardness (SH). The biofilms were exposed to sucrose 10% or glucose + fructose 10.5% (carbohydrates that differ on EPS formation), 8x/day but were maintained in starvation during the night. Biofilm samples were harvested during two moments, on the end of the 4th day and in the morning of the 5th day, conditions of sugar abundance and starvation, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28709424/genotypic-diversity-and-phenotypic-traits-of-streptococcus-mutans-isolates-and-their-relation-to-severity-of-early-childhood-caries
#5
Remberto Marcelo Argandoña Valdez, Cristiane Duque, Karina Sampaio Caiaffa, Vanessa Rodrigues Dos Santos, Maria Luiza de Aguiar Loesch, Natalia Helena Colombo, Rodrigo Alex Arthur, Thais de Cássia Negrini, Marcelo Fabiano Gomes Boriollo, Alberto Carlos Botazzo Delbem
BACKGROUND: Early childhood caries (ECC) is an aggressive condition that can affect teeth of young children. This study aimed to evaluate genotypic diversity and phenotypic traits of S. mutans isolated from dental biofilms of children with different caries status in comparison with caries free (CF) children. METHODS: Streptococcus mutans strains were isolated from supragingival biofilm samples of CF, ECC and severe-ECC (S-ECC) children and genotyped by arbitrary-primer polymerase chain reaction - AP-PCR...
July 14, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28709393/microbiome-associated-with-severe-caries-in-canadian-first-nations-children
#6
M Agnello, J Marques, L Cen, B Mittermuller, A Huang, N Chaichanasakul Tran, W Shi, X He, R J Schroth
Young Indigenous children in North America suffer from a higher degree of severe early childhood caries (S-ECC) than the general population, leading to speculation that the etiology and characteristics of the disease may be distinct in this population. To address this knowledge gap, we conducted the first microbiome analysis of an Indigenous population using modern molecular techniques. We investigated the caries-associated microbiome among Canadian First Nations children with S-ECC. Thirty First Nations children <72 mo of age with S-ECC and 20 caries-free children were recruited in Winnipeg, Canada...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28708089/effects-of-consuming-xylitol-on-gut-microbiota-and-lipid-metabolism-in-mice
#7
Takashi Uebanso, Saki Kano, Ayumi Yoshimoto, Chisato Naito, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi
The sugar alcohol xylitol inhibits the growth of some bacterial species including Streptococcus mutans. It is used as a food additive to prevent caries. We previously showed that 1.5-4.0 g/kg body weight/day xylitol as part of a high-fat diet (HFD) improved lipid metabolism in rats. However, the effects of lower daily doses of dietary xylitol on gut microbiota and lipid metabolism are unclear. We examined the effect of 40 and 200 mg/kg body weight/day xylitol intake on gut microbiota and lipid metabolism in mice...
July 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28705510/the-chemical-composition-of-the-pharmacologically-active-thymus-species-its-antibacterial-activity-against-streptococcus-mutans-and-the-antiadherent-effects-of-t-vulgaris-on-the-bacterial-colonization-of-the-in-situ-pellicle
#8
Gesche Schött, Stefanie Liesegang, Franziska Gaunitz, Alexandra Gleß, Sabine Basche, Christian Hannig, Karl Speer
The pharmacological active genus Thymus L. comprises over 200 species. Besides its traditional pharmacological use, thyme may reduce the risk of caries disease, however, there is very little respective literature. The pharmacological effects can be attributed to the secondary plant metabolites. The composition of the essential oil and the polyphenols is important for the evaluation of the pharmacological activity. Nevertheless, there are no studies regarding a comparative analysis of the different pharmacological thyme species...
July 10, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28705197/genetic-polymorphism-of-scra-gene-of-streptococcus-mutans-isolates-is-not-associated-with-biofilm-formation-in-severe-early-childhood-caries
#9
Yan Zhou, Lixia Yu, Ye Tao, Qinghui Zhi, Huancai Lin
BACKGROUND: To explore and analyse the association between biofilm and the genetic polymorphisms of scrA gene of EnzymeIIscr found in clinical isolates of Streptococcus mutans (S. mutans) from severe early childhood caries (S-ECC) in 3 years old children. METHODS: Clinical strains of S. mutans were conserved from a previous study. Thirty strains of S. mutans from the S-ECC group and 30 strains of S. mutans from the caries free (CF) group were selected. Biomass and viability of biofilm formed by the strains were evaluated by crystal violet and alamar blue assay...
July 14, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28702060/oral-health-status-salivary-ph-status-and-streptococcus-mutans-counts-in-dental-plaques-and-saliva-of-children-with-acute-lymphoblastic-leukemia
#10
Romina Mazaheri, Ebrahim Jabbarifar, Elnaz Ghasemi, Elahe Akkafzadeh, Elmira Poursaeid
BACKGROUND: Acute lymphoblastic leukemia (ALL), accounting for 23% of all malignancies in children, is the most prevalent pediatric malignancy. This study compared dental caries, oral hygiene status, salivary pH, and Streptococcus mutans counts in dental plaques and saliva of children with leukemia with those of healthy controls. MATERIALS AND METHODS: This case-control cross-sectional study assessed 32 children with ALL and 32 healthy children (4-9-year-old) for gingival bleeding index (GBI), decayed, missing, and filled/decayed, missing, and filled surfaces (DMF/dmfs), and plaque index (PI)...
May 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28698734/methods-of-biotyping-of-streptococcus-mutans-species-with-the-routine-test-as-a-prognostic-value-in-early-childhood-caries
#11
Wirginia Krzyściak, Dorota Kościelniak, Monika Papież, Anna Jurczak, Palina Vyhouskaya
PURPOSE: In order to investigate the suitability of Streptococcus mutans species biotyping by measuring the activity of selected enzymes from a commercial test, criteria were established for biotyping clinical strains from children with dental caries. In addition, the relationships between the selected biotypes, sensitivity to commonly used antibiotics, and early childhood caries were determined. METHODS: A total of 142 S. mutans isolates from dental plaque of children with caries were divided into different biotypes...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28692914/antibiofilm-potential-of-16-oxo-cleroda-3-13-14-e-diene-15-oic-acid-and-its-five-new-%C3%AE-amino-%C3%AE-lactone-derivatives-against-methicillin-resistant-staphylococcus-aureus-and-streptococcus-mutans
#12
Anum Khalid Khan, Ayaz Ahmed, Mustafa Hussain, Ishtiaq Ahmad Khan, Syed Abid Ali, Ahsana Dar Farooq, Shaheen Faizi
The clerodane diterpenoids 16-oxo-cleroda-3, 13(14) E-diene-15 oic acid (1) and kolavenic acid (2) isolated from Polyalthia longifolia var. pendula (Linn.) were previously reported for their antimicrobial activity. Thus present study was designed to investigate the biofilm inhibiting potential of these diterpenoids (1-2) and five new lactone derivatives (3-7) of 1 against methicillin resistant Staphylococcus aureus (MRSA), Streptococcus mutans, Klebsiella pneumoniae and Proteus mirabilis. Compounds 1 and 3 at 10-20 μg/mL were found to be bacteriostatic and significantly reduced the biofilm formation and metabolically active cells of MRSA and S...
June 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28687645/deficiency-of-rgpg-causes-major-defects-in-cell-division-and-biofilm-formation-and-deficiency-of-lcp-proteins-leads-to-accumulation-of-cell-wall-antigens-in-culture-medium-by-streptococcus-mutans
#13
Arpan De, Sumei Liao, Jacob P Bitoun, Randy Roth, Wandy L Beatty, Hui Wu, Zezhang T Wen
S. mutans is known to possess rhamnose-glucose polysaccharides (RGP), a major cell wall antigen. S. mutans strains deficient of rgpG, encoding the first enzyme of the RGP biosynthesis pathway, were constructed by allelic exchange. The rgpG deficiency had no effect on growth rate, but caused major defects in cell division and altered cell morphology. Unlike the coccoid wild-type, the rgpG mutant existed primarily in chains of swollen, squarish dividing cells. Deficiency of rgpG also causes significant reduction in biofilm formation (P<0...
July 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28683409/thymus-vulgaris-l-extract-has-antimicrobial-and-anti-inflammatory-effects-in-the-absence-of-cytotoxicity-and-genotoxicity
#14
Jonatas Rafael de Oliveira, Daiane de Jesus Viegas, Ana Paula Réquia Martins, Cláudio Antonio Talge Carvalho, Cristina Pacheco Soares, Samira Esteves Afonso Camargo, Antonio Olavo Cardoso Jorge, Luciane Dias de Oliveira
OBJECTIVES: This study evaluated the biological effects of the T. vulgaris L. extract., such as antimicrobial activity on planktonic cultures and mono- and polymicrobial biofilms, cytotoxicity, anti-inflammatory activity and genotoxicity. METHODS: Monomicrobial biofilms of Candida albicans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans and Pseudomonas aeruginosa and polymicrobial biofilms composed by C. albicans with each bacterium were formed for 48h and exposed for 5min to the plant extract...
June 27, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28681586/effects-on-cytotoxicity-and-antibacterial-properties-of-the-incorporations-of-silver-nanoparticles-into-the-surface-coating-of-dental-alloys
#15
Xiao-Ting Shen, Yan-Zhen Zhang, Fang Xiao, Jing Zhu, Xiao-Dong Zheng
The aim of this study was to research the changes in cytotoxicity and antibacterial properties after silver nanoparticles (AgNPs) were incorporated into the surface coating of dental alloys. AgNPs were attached to cobalt chromium alloys and pure titanium using a hydrothermal method, according to the reaction: AgNO3+NaBH4→ Ag+1/2H2+1/2B2H6+NaNO3. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to evaluate the cytotoxicity of the alloys when in contact with osteogenic precursor cells (MC3T3-E1) from mice and mesenchymal stem cells (BMSC) from rats...
July 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28680554/characterization-and-antimicrobial-efficacy-of-portland-cement-impregnated-with-silver-nanoparticles
#16
Ki Young Nam
PURPOSE: This study investigated the effects of silver nanoparticle (SN) loading into hydraulic calcium silicate-based Portland cement on its mechanical, antibacterial behavior and biocompatibility as a novel dental bone substitute. MATERIALS AND METHODS: Chemically reduced colloidal SN were combined with Portland cement (PC) by the concentrations of 0 (control), 1.0, 3.0, and 5.0 wt%. The physico-mechanical properties of silver-Portland cement nanocomposites (SPNC) were investigated through X-ray diffraction (XRD), setting time, compressive strength, solubility, and silver ion elution...
June 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28678943/salivary-density-of-streptococcus-mutans-and-streptococcus-sobrinus-and-dental-caries-in-children-and-adolescents-with-down-syndrome
#17
Flávia Scalioni, Camila Carrada, Fernanda Machado, Karina Devito, Luiz Cláudio Ribeiro, Dionéia Cesar, Rosangela Ribeiro
Objective: To assess and compare dental caries experience and salivary S. mutans, S. sobrinus, and streptococci counts between groups of Down syndrome and non-Down syndrome children and adolescents. Material and Methods: This study included a sample of 30 Down syndrome children and adolescents (G-DS) and 30 age- and sex-matched non-Down syndrome subjects (G-ND). Dental caries experience was estimated by the number of decayed, missing, and filled teeth in the primary dentition and the permanent dentition...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28678838/the-oral-bacterial-microbiome-of-occlusal-surfaces-in-children-and-its-association-with-diet-and-caries
#18
Apoena Aguiar Ribeiro, Maria Andrea Azcarate-Peril, Maria Belen Cadenas, Natasha Butz, Bruce J Paster, Tsute Chen, Eric Bair, Roland R Arnold
Dental caries is the most prevalent disease in humans globally. Efforts to control it have been invigorated by an increasing knowledge of the oral microbiome composition. This study aimed to evaluate the bacterial diversity in occlusal biofilms and its relationship with clinical surface diagnosis and dietary habits. Anamneses were recorded from thirteen 12-year-old children. Biofilm samples collected from occlusal surfaces of 46 permanent second molars were analyzed by 16S rRNA amplicon sequencing combined with the BLASTN-based search algorithm for species identification...
2017: PloS One
https://www.readbyqxmd.com/read/28675006/-construction-of-a-low-ph-sensing-system-in-streptococcus-mutans
#19
Kang Di, Li Yuqing, Zhou Xuedong
OBJECTIVE: To construct a low-pH-sensing system in Streptococcus mutans (S. mutans) and to visually detect the pH in situ. METHODS: Promoter of ureaseⅠ(PureⅠ) and green fluorescence protein (gfp) DNA fragments were amplified by polymerase chain reaction (PCR) from the genome of Streptococcus salivarius 57.I and S. mutans containing the gfp fragment. The two amplified DNA fragments were ligated together and further integrated into pDL278 to construct the recombinant plasmid pDL278-pureⅠ-gfp...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28674707/propolis-extracted-from-the-stingless-bee-trigona-sirindhornae-inhibited-s-mutans-activity-in-vitro
#20
Kusumawadee Utispan, Bordin Chitkul, Paopanga Monthanapisut, Ladda Meesuk, Kamolparn Pugdee, Sittichai Koontongkaew
PURPOSE: The aim of this study was to determine the antimicrobial effects of propolis extracted from an endemic species of stingless bee, T. sirindhornae, on the cariogenic bacterium Streptococcus mutans. MATERIALS AND METHODS: Dichloromethane extracts (DME) of propolis (DMEP) were prepared and analysed by reverse-phase high-performance liquid chromatography. The antibacterial growth and antibiofilm formation effects of DMEP on S. mutans were compared with those of apigenin, a commercial propolis product...
2017: Oral Health & Preventive Dentistry
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