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https://www.readbyqxmd.com/read/28811592/high-performance-therapeutic-quercetin-doped-adhesive-for-adhesive-dentin-interfaces
#1
Hongye Yang, Kang Li, Huiyi Yan, Siying Liu, Yake Wang, Cui Huang
Almost half of dental restorations have failed in less than 10 years, and approximately 60% of practice time has been consumed to replace these dental restorations. As such, contemporary dentin adhesives should be modified to treat secondary caries and prevent the degradation of adhesive-dentin interfaces. To achieve this goal, we developed a versatile therapeutic adhesive in the present study by incorporating quercetin, which is a naturally derived plant extract, into a commercial adhesive at three concentrations (100, 500 and 1000 µg/mL)...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808691/fluoride-depletes-acidogenic-taxa-in-oral-but-not-gut-microbial-communities-in-mice
#2
Koji Yasuda, Tiffany Hsu, Carey A Gallini, Lauren J Mclver, Emma Schwager, Andy Shi, Casey R DuLong, Randall N Schwager, Galeb S Abu-Ali, Eric A Franzosa, Wendy S Garrett, Curtis Huttenhower, Xochitl C Morgan
Fluoridation of drinking water and dental products prevents dental caries primarily by inhibiting energy harvest in oral cariogenic bacteria (such as Streptococcus mutans and Streptococcus sanguinis), thus leading to their depletion. However, the extent to which oral and gut microbial communities are affected by host fluoride exposure has been underexplored. In this study, we modeled human fluoride exposures to municipal water and dental products by treating mice with low or high levels of fluoride over a 12-week period...
July 2017: MSystems
https://www.readbyqxmd.com/read/28808327/spontaneous-detachment-of-streptococcus-mutans-biofilm-by-synergistic-effect-between-zwitterion-and-sugar-alcohol
#3
Jong Hyun Lim, Sang-Hun Song, Hyun-Sub Park, Jeong Rae Lee, Sang-Min Lee
A biofilm, a community of microorganisms, is highly resistant to antibiotics, resulting in massive losses in various areas. We herein present a strategy to remove Streptococcus mutans biofilms through a spontaneous exfoliation by the synergistic effect between zwitterion and sugar alcohols. It is assumed that the anionic site of zwitterion can be coupled with sugar alcohols and the cationic site remains in the state of lacking electrons. The cationic site allows the complexes to be delivered to negatively charged exopolysaccharides of biofilms...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808205/farnesol-inhibits-development-of-caries-by-augmenting-oxygen-sensitivity-and-suppressing-virulence-associated-gene-expression-instreptococcus-mutans
#4
Li Cao, Zhen-Zhen Zhang, Shuang-Bo Xu, Ming Ma, Xin Wei
Streptococcus mutans is a primary etiological agent of dental caries. Farnesol, as a potential antimicrobial agent, inhibits the development ofS. mutans biofilm. In this study, we hypothesized that farnesol inhibits caries development in vitro and interferes with biofilm formation by regulating virulence-associated gene expression. The inhibitory effects of farnesol to S. mutans biofilms on enamel surfaces were investigated by determining micro-hardness and calcium measurements. Additionally, the morphological changes ofS...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28808131/intercellular-communication-via-the-comx-inducing-peptide-xip-of-streptococcus-mutans
#5
Justin Kaspar, Simon A M Underhill, Robert C Shields, Adrian Reyes, Suzanne Rosenzweig, Stephen J Hagen, Robert A Burne
Gram-positive bacteria utilize exported peptides to coordinate genetic and physiological processes required for biofilm formation, stress responses and ecological competitiveness. One example is activation of natural genetic competence by ComR and the comX-inducing peptide (XIP) in Streptococcus mutans Although the competence pathway can be activated by addition of synthetic XIP in defined medium, the hypothesis that XIP is able to function as an intercellular signal molecule has not been rigorously tested...
August 14, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28807573/axially-substituted-silicon-iv-phthalocyanine-and-its-quaternized-derivative-as-photosensitizers-towards-tumor-cells-and-bacterial-pathogens
#6
İpek Ömeroğlu, Esra Nur Kaya, Meltem Göksel, Vesselin Kussovski, Vanya Mantareva, Mahmut Durmuş
Axially di-(alpha,alpha-diphenyl-4-pyridylmethoxy) silicon(IV) phthalocyanine (3) and its quaternized derivative (3Q) were synthesized and tested as photosensitizers against tumor and bacterial cells. These new phthalocyanines were characterized by elemental analysis, and different spectroscopic methods such as FT-IR, UV-Vis, MALDI-TOF and (1)H NMR. The photophysical properties such as absorption and fluorescence, and the photochemical properties such as singlet oxygen generation of both phthalocyanines were investigated in solutions...
August 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28791813/an-evaluation-of-selected-oral-health-indicators-and-cariogenic-bacteria-titer-in-patients-with-helicobacter-pylori
#7
Jakub Urban, Rafał Koszowski, Anna Płachetka, Andrzej Wiczkowski
BACKGROUND: Studies based on polymerase chain reaction (PCR) techniques indicate that Helicobacter pylori can be constantly or temporarily present in the oral cavity in virulent or non-virulent form. Streptococcus mutans exerts a strong inhibitory effect on H. pylori. OBJECTIVES: The aim of the present study was to investigate the prevalence and virulence of H. pylori in the oral cavity and the correlation of these factors with oral health and cariogenic bacteria titer...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28783550/characterization-of-the-clustered-regularly-interspaced-short-palindromic-repeats-sites-in-streptococcus-mutans-isolated-from-early-childhood-caries-patients
#8
Jing Chen, Tiancheng Li, Xuedong Zhou, Lei Cheng, Yuanyuan Huo, Jing Zou, Yuqing Li
OBJECTIVE: The aim of this study was to analyze the characteristics of the clustered regularly interspaced short palindromic repeats (CRISPR) sites in 45 clinical Streptococcus mutans strains and their relationship to the clinical manifestations of early childhood caries (ECC). METHODS: Forty-five S. mutans strains were isolated from the plaque samples taken from sixty-three children. CRISPR sites were sequenced and BLAST was used to compare these sites to those in the CRISPRTarget database...
July 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28783506/nanoscale-silver-depositions-inhibit-microbial-colonization-and-improve-biocompatibility-of-titanium-abutments
#9
Supriya Kheur, Nimisha Singh, Dhananjay Bodas, Jean-Yves Rauch, Shantanu Jambhekar, Mohit Kheur, Jyutika Rajwade
Although titanium dental implants are biocompatible, exhibit excellent corrosion resistance and high mechanical resistance, the material fails in providing resistance to infection because it exhibits poor antimicrobial activity. To address these issues, we deposited silver onto titanium abutments (Grade 5 titanium discs) using direct current (DC) sputtering and assessed the antimicrobial activity and biocompatibility of the modified implant material. Atomic absorption spectrometry and X-ray photoelectron spectroscopy were employed to investigate the concentration and elemental composition of the deposited silver...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28775282/ecological-effect-of-arginine-on-oral-microbiota
#10
Xin Zheng, Jinzhi He, Lin Wang, Shuangshuang Zhou, Xian Peng, Shi Huang, Liwei Zheng, Lei Cheng, Yuqing Hao, Jiyao Li, Jian Xu, Xin Xu, Xuedong Zhou
Dental caries is closely associated with the microbial dybiosis between acidogenic/aciduric pathogens and alkali-generating commensal bacteria colonized in the oral cavity. Our recent studies have shown that arginine may represent a promising anti-caries agent by modulating microbial composition in an in vitro consortium. However, the effect of arginine on the oral microbiota has yet to be comprehensively delineated in either clinical cohort or in vitro biofilm models that better represent the microbial diversity of oral cavity...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774430/modulation-of-streptococcus-mutans-virulence-by-dental-adhesives-containing-anti-caries-agents
#11
Carolina Bosso André, Pedro Luiz Rosalen, L C C Galvão, Bruna Marin Fronza, Glaucia Maria Bovi Ambrosano, Jack Liborio Ferracane, Marcelo Giannini
OBJECTIVES: The aim of this in vitro study was to analyze the effect of the incorporation of two anti-caries agents into dental adhesives on the reduction of the virulence of Streptococcus mutans and on the adhesion to dentin. METHODS: Apigenin (1mM) and tt-Farnesol (5mM) were added separately and in combination to a self-etch adhesive (CS3 - Clearfil S3 Bond Plus) and to an each-and-rinse adhesive (OPT - OptiBond S). Biofilm of S. mutans was grown on adhesive-coated hydroxyapatite disks for 115h and bacterial viability, dry-weight, alkali soluble, water soluble, intracellular polysaccharides and protein were quantified...
July 31, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28773004/anti-caries-effects-of-dental-adhesives-containing-quaternary-ammonium-methacrylates-with-different-chain-lengths
#12
Qi Han, Bolei Li, Xuedong Zhou, Yang Ge, Suping Wang, Mingyun Li, Biao Ren, Haohao Wang, Keke Zhang, Hockin H K Xu, Xian Peng, Mingye Feng, Michael D Weir, Yu Chen, Lei Cheng
The objectives of this study were to investigate the effects of dental adhesives containing quaternary ammonium methacrylates (QAMs) with different alkyl chain lengths (CL) on ecological caries prevention in vitro. Five QAMs were synthesized with a CL = 3, 6, 9, 12, and 16 and incorporated into adhesives. Micro-tensile bond strength and surface charge density were used to measure the physical properties of the adhesives. The proportion change in three-species biofilms consisting of Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii was tested using the TaqMan real-time polymerase chain reaction...
June 12, 2017: Materials
https://www.readbyqxmd.com/read/28772546/epigallocatechin-3-gallate-and-epigallocatechin-3-o-3-o-methyl-gallate-enhance-the-bonding-stability-of-an-etch-and-rinse-adhesive-to-dentin
#13
Hao-Han Yu, Ling Zhang, Fan Yu, Fang Li, Zheng-Ya Liu, Ji-Hua Chen
This study evaluated epigallocatechin-3-gallate (EGCG) and epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG-3Me) modified etch-and-rinse adhesives (Single Bond 2, SB 2) for their antibacterial effect and bonding stability to dentin. EGCG-3Me was isolated and purified with column chromatography and preparative high performance liquid chromatography. EGCG and EGCG-3Me were incorporated separately into the adhesive SB 2 at concentrations of 200, 400, and 600 µg/mL. The effect of cured adhesives on the growth of Streptococcus mutans (S...
February 15, 2017: Materials
https://www.readbyqxmd.com/read/28772391/novel-dental-adhesive-with-biofilm-regulating-and-remineralization-capabilities
#14
Yang Ge, Biao Ren, Xuedong Zhou, Hockin H K Xu, Suping Wang, Mingyun Li, Michael D Weir, Mingye Feng, Lei Cheng
The mechanical properties and anti-caries effect of a novel anti-caries adhesive containing poly (amidoamine) dendrimer (PAMAM) and dimethylaminododecyl methacrylate (DMADDM) were investigated for the first time. Microtensile bond strength and surface charge density were measured for the novel anti-caries adhesives. Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii were chosen to form three-species biofilms. Lactic acid assay, MTT (3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, exopolysaccharide staining and live/dead staining were performed to study anti-biofilm effect of the adhesive...
January 3, 2017: Materials
https://www.readbyqxmd.com/read/28767890/chemical-composition-antioxidant-and-antibacterial-activities-of-essential-oils-from-leaves-and-flowers-of-eugenia-klotzschiana-berg-myrtaceae
#15
Nárgella S Carneiro, Cassia C F Alves, José M Alves, Mariana B Egea, Carlos H G Martins, Thayná S Silva, Lizandra C Bretanha, Maira P Balleste, Gustavo A Micke, Eduardo V Silveira, Mayker L D Miranda
Many essential oils (EOs) of different plant species possess interesting antimicrobial effects on buccal bacteria and antioxidant properties. Eugenia klotzschiana Berg (pêra-do-cerrado, in Portuguese) is a species of Myrtaceae with restricted distribution in the Cerrado. The essential oils were extracted through the hydrodistillation technique using a modified Clevenger apparatus (2 hours) and chemically characterized by GC-MS. The major compounds were α-copaene (10.6 %) found in oil from leaves in natura, β-bisabolene (17...
July 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28766815/rhamnolipids-and-lactonic-sophorolipids-natural-antimicrobial-surfactants-for-oral-hygiene
#16
M Elshikh, I Moya-Ramírez, H Moens, S Roelants, W Soetaert, R Marchant, I M Banat
AIMS: To assess the efficacy of rhamnolipid (mixture of mono- and di-rhamnolipid congeners, purified monorhamnolipid, dirhamnolipid and lactonic sophorolipid biosurfactants against pathogens important for oral hygiene. METHODS AND RESULTS: Acquired and produced biosurfactants were fully characterised to allow the antimicrobial activity to be assigned to the biosurfactant congeners. Antimicrobial activity was assessed using the resazurin aided microdilution method...
August 2, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28764202/antimicrobial-effect-of-leaves-of-phyllanthus-niruri-and-solanum-nigrum-on-caries-causing-bacteria-an-in-vitro-study
#17
J Sunitha, Swathy Krishna, R Ananthalakshmi, J Sathiya Jeeva, As Smiline Girija, Nadeem Jeddy
INTRODUCTION: Solanum nigrum and Phyllanthus niruri are common herbs which are indigeneous to India. Solanum nigrum commonly called 'manathakkali Keerai' in Tamil, forms an indispensable part of South Indian diet. Phyllanthus niruri (keezhanelli in Tamil) is a widely used medicinal plant, the leaves of which have been used extensively in Ayurveda and native medicine to cure various liver ailments. The herbs Solanumnigrum and Phyllanthus niruri have been found to be effective against numerous enteropathogens in various in vitro studies...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28762343/assessment-of-maternal-risk-factors-and-its-relationship-with-early-childhood-caries-among-preschool-children-in-mangaluru-city
#18
Sham S Bhat, Sundeep Hegde, Vidya Bhat, K M Ramya, Praveen Jodalli
AIM: The aim of this study is to assess the maternal risk factors and its relationship with early childhood caries (ECC) among preschoolchildren in Mangaluru city. METHODS: Children aged 3-5 years attending preschool (Anganwadi) and their mothers were included in the study. A total of 120 child-mother pairs participated in the study. The maternal risk factors were assessed by a pretested questionnaire. After obtaining the consent, the mother and their children were clinically examined for dental caries using the WHO criteria (1997)...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28762193/probiotic-features-of-lactic-acid-bacteria-isolated-from-a-diverse-pool-of-traditional-greek-dairy-products-regarding-specific-strain-host-interactions
#19
Georgia Zoumpopoulou, Alexandra Tzouvanou, Eleni Mavrogonatou, Voula Alexandraki, Marina Georgalaki, Rania Anastasiou, Marina Papadelli, Eugenia Manolopoulou, Maria Kazou, Dimitris Kletsas, Konstantinos Papadimitriou, Effie Tsakalidou
The increased consumers' interest on the positive role of food in wellbeing and health underscores the need to determine new probiotic microorganisms. Triggered by the fact that artisanal food products can be a valuable source of novel probiotic strains, 106 lactic acid bacteria, all isolated from traditional Greek dairy products, namely Feta, Kasseri, Xynotyri, Graviera, Formaela, Galotyri, and Kefalotyri cheeses as well as yogurt and milk, were studied for probiotic properties. Based on their survival at pH 2...
July 31, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28759297/self-assembling-anticaries-mucosal-vaccine-containing-ferritin-cage-nanostructure-and-glucan-binding-region-of-s-mutans-glucosyltransferase-effectively-prevents-caries-formation-in-rodents
#20
Xi-Xi Cao, Yu-Hong Li, Qian-Lin Ye, Tian-Feng Wang, Ming-Wen Fan
Anticaries protein vaccines that induce a mucosal immune response are not effective. Therefore, development of effective and convenient anticaries vaccines is a priority of dental research. Here we generated self-assembling nanoparticles by linking the glucan-binding region of Streptococcus mutans glucosyltransferase (GLU) to the N-terminal domain of ferritin to determine whether these novel nanoparticles enhanced the immunogenicity of an anticaries protein vaccine against GLU in rodents. We constructed the expression plasmid pET28a-GLU-FTH and purified the proteins from bacteria using size-exclusion chromatography...
July 31, 2017: Human Vaccines & Immunotherapeutics
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