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Streptococcus mutans

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https://www.readbyqxmd.com/read/27907988/kr12-peptide-associated-with-cyclodextrin-antimicrobial-and-antitumor-activities
#1
Karina I R Teixeira, Maria E Cortés, Robson A S Santos, Flávio Oliveira, Ruben D Sinisterra
The aim of this study was to determine the physical properties and antimicrobial and antiproliferative effects of the KR12 peptide complexed with 2-hydroxypropyl-β-cyclodextrin (Hp-βCd) in vitro. The KR12:Hp-βCd composition was evaluated for particle size and its zeta (ζ)-potential in the presence and absence of cells. Antimicrobial activity against Streptococcus mutans, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis for the peptide alone or associated was evaluated by minimal inhibitory concentration...
December 1, 2016: Biointerphases
https://www.readbyqxmd.com/read/27907861/in-situ-time-lapse-study-of-extracellular-polymeric-substance-discharge-in-streptococcus-mutans-biofilm
#2
Bernard Haochih Liu, Li-Chieh Yu
Streptococcus mutans is one of the main pathogens that cause tooth decay. By metabolizing carbohydrates, S. mutans emits extracellular polymeric substance (EPS) that adheres to the tooth surface and forms layers of biofilm. Periodontal disease occurs due to the low pH environment created by S. mutans biofilm, and such an acidic environment gradually erodes tooth enamel. Since the existence of EPS is essential in the formation of biofilm, the in-situ investigation of its generation and distribution in real time is the key to the control and suppression of S...
November 24, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27901206/antimicrobial-activity-of-different-disinfectants-against-cariogenic-microorganisms
#3
Esra Uzer Celik, Ayse Tugce Tunac, Mustafa Ates, Bilge Hakan Sen
The aim of this study was to assess the in vitro antimicrobial effects of chlorhexidine digluconate (CHX), polyhexamethylene biguanide (PHBM), and octenidine dihydrochloride (OCT) on cariogenic microorganisms by using their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). CHX, PHBM, and OCT were diluted in distilled water to the final test concentrations. Using the in-tube dilution method, Streptococcus mutans, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Actinomyces viscosus were cultivated on blood agar and Mueller-Hinton broth (MHB) at 37°C for 48 h...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27898021/salivary-microbiome-diversity-in-caries-free-and-caries-affected-children
#4
Shan Jiang, Xiaoli Gao, Lijian Jin, Edward C M Lo
Dental caries (tooth decay) is an infectious disease. Its etiology is not fully understood from the microbiological perspective. This study characterizes the diversity of microbial flora in the saliva of children with and without dental caries. Children (3-4 years old) with caries (n = 20) and without caries (n = 20) were recruited. Unstimulated saliva (2 mL) was collected from each child and the total microbial genomic DNA was extracted. DNA amplicons of the V3-V4 hypervariable region of the bacterial 16S rRNA gene were generated and subjected to Illumina Miseq sequencing...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27892838/effect-of-bioactive-primers-on-bacterial-induced-secondary-caries-at-the-tooth-resin-interface
#5
G E Kim, A A Leme-Kraus, R Phansalkar, G Viana, C Wu, S-N Chen, G F Pauli, Akb Bedran-Russo
Secondary caries at the tooth-resin interface is the primary reason for replacement of resin composite restorations. The tooth-resin interface is formed by the interlocking of resin material with hydroxyapatite crystals in enamel and collagen mesh structure in dentin. Efforts to strengthen the tooth-resin interface have identified chemical agents with dentin collagen cross-linking potential and antimicrobial activities. The purpose of the present study was to assess protective effects of bioactive primer against secondary caries development around enamel and dentin margins of class V restorations, using an in vitro bacterial caries model...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27891311/comparison-of-antibacterial-efficacy-of-coconut-oil-and-chlorhexidine-on-streptococcus-mutans-an-in-vivo-study
#6
Faizal C Peedikayil, Vimal Remy, Seena John, T P Chandru, Prathima Sreenivasan, Gufran Ahmed Bijapur
AIMS: Streptococcus mutans is the most common organism causing dental caries. Various chemotherapeutic agents are available that help in treating the bacteria, with each having their own merits and demerits. Recent research has shown that coconut oil has anti-inflammatory and antimicrobial action. Therefore, the present was conducted to determine the antibacterial efficacy of coconut oil and to compare it with chlorhexidine. MATERIALS AND METHODS: A total of fifty female children aged 8-12 years were included in the study...
September 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27891308/comparative-evaluation-of-the-efficacy-of-fluoride-varnish-and-casein-phosphopeptide-amorphous-calcium-phosphate-in-reducing-streptococcus-mutans-counts-in-dental-plaque-of-children-an-in-vivo-study
#7
Shweta Chandak, Ashish Bhondey, Amit Bhardwaj, Jitesh Pimpale, Manisha Chandwani
AIM: To assess the comparative efficacy of fluoride varnish and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) complex visa viz. Streptococcus mutans in plaque, and thereby the role that these two agents could play in the prevention of dental caries. MATERIALS AND METHODS: A cluster sample of 120 caries inactive individuals belonging to moderate and high caries risk group were selected from 3-5-year-old age group based on the criteria given by Krassee and were randomized to four groups, namely, fluoride varnish - Group I, CPP-ACP complex - Group II, mixture of CPP-ACP complex -Gourp III, and fluoride and routine oral hygiene procedures as control - Group IV...
September 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27887775/bactericidal-dental-nanocomposites-containing-1-2-3-triazolium-functionalized-poss-additive-prepared-through-thiol-ene-click-polymerization
#8
Saeed Beigi Burujeny, Hamid Yeganeh, Mohammad Atai, Hoshyar Gholami, Marzieh Sorayya
OBJECTIVE: Deterioration of mechanical strength for the dental composite containing ionic bactericidal compounds restricts the widespread utilization of this class of useful materials. This problem is originated from the reduction of the intermolecular interaction of polymeric network due to plasticization effect of absorbed water molecules penetrated between the chain segments. The main goal of this study is the synthesis of the highly efficient bactericidal additive with low hydrophilicity and consequently the least adverse effect on the final mechanical strength of the dental composite...
November 22, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27885785/osteogenic-activity-and-antibacterial-effect-of-porous-titanium-modified-with-metal-organic-framework-films
#9
Junyu Chen, Xin Zhang, Chao Huang, He Cai, Shanshan Hu, Qianbing Wan, Xibo Pei, Jian Wang
As a new class of crystalline nanoporous materials, metal-organic frameworks (MOFs) have recently been used for biomedical applications due to their large surface area, high porosity, and theoretically infinite structures. To improve the biological performance of titanium, MOF films were applied to surface modification of titanium. Zn-based MOF films composed of zeolitic imidazolate framework-8 (ZIF-8) crystals with nanoscale and microscale sizes (nanoZIF-8 and microZIF-8) were prepared on porous titanium surfaces by hydrothermal and solvothermal methods, respectively...
November 5, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27880799/treatment-of-oral-biofilms-by-a-d-enantiomeric-peptide
#10
Tian Zhang, Zhejun Wang, Robert E W Hancock, César de la Fuente-Núñez, Markus Haapasalo
Almost all dental diseases are caused by biofilms that consist of multispecies communities. DJK-5, which is a short D-enantiomeric, protease-resistant peptide with broad-spectrum anti-biofilm activity, was tested for its effect on oral multispecies biofilms. Peptide DJK-5 at 10 μg/mL effectively prevented the growth of these microbes in culture media in a time-dependent manner. In addition to the prevention of growth, peptide DJK-5 completely killed both Streptococcus mutans and Enterococcus faecalis suspended from biofilms after 30 minutes of incubation in liquid culture media...
2016: PloS One
https://www.readbyqxmd.com/read/27869143/genome-mining-unveils-widespread-natural-product-biosynthetic-capacity-in-human-oral-microbe-streptococcus-mutans
#11
Liwei Liu, Tingting Hao, Zhoujie Xie, Geoff P Horsman, Yihua Chen
Streptococcus mutans is a major pathogen causing human dental caries. As a Gram-positive bacterium with a small genome (about 2 Mb) it is considered a poor source of natural products. Due to a recent explosion in genomic data available for S. mutans strains, we were motivated to explore the natural product production potential of this organism. Bioinformatic characterization of 169 publically available genomes of S. mutans from human dental caries revealed a surprisingly rich source of natural product biosynthetic gene clusters...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853108/efficacy-and-safety-of-a-therapeutic-apparatus-using-hydrogen-peroxide-photolysis-to-treat-dental-and-periodontal-infectious-diseases
#12
Hirohisa Sato, Yoshimi Niwano, Keisuke Nakamura, Takayuki Mokudai, Hiroyo Ikai, Taro Kanno, Hiroshi Egusa
The present study aimed to evaluate the acute locally injurious property of our most current hydroxyl radical generation system by hydrogen peroxide (H2O2) photolysis. This system, which releases 3% H2O2 with a 405-nm laser, was developed in our laboratory for the treatment of dental and periodontal infectious diseases. First, the hydroxyl radical yield generated by H2O2 photolysis was examined by applying an electron spin resonance-spin trapping technique. Second, the bactericidal effect of the device was examined under a simulant condition in which Streptococcus mutans, a pathogenic bacterial species that causes caries, was irrigated with running 3% H2O2 concomitantly with laser irradiation...
2016: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/27849122/streptococcus-mutans-adhesion-on-nickel-titanium-niti-and-copper-niti-archwires-a-comparative-prospective-clinical-study
#13
Kirubaharan S Abraham, Nithya Jagdish, Vignesh Kailasam, Sridevi Padmanabhan
OBJECTIVES: To compare the adhesion of Streptococcus mutans to nickel titanium (NiTi) and copper-NiTi (Cu-NiTi) archwires and to correlate the adhesion to surface characteristics (surface free energy and surface roughness) of these wires. MATERIALS AND METHODS: A total of 16 patients undergoing orthodontic treatment with preadjusted edgewise appliances were included in the study. 0.016" and 0.016" × 0.022" NiTi and Cu-NiTi archwires in as-received condition and after 4 weeks of intraoral use were studied for S mutans adhesion using real-time polymerase chain reaction...
November 16, 2016: Angle Orthodontist
https://www.readbyqxmd.com/read/27847749/comparative-assessment-of-antibacterial-activity-of-different-glass-ionomer-cements-on-cariogenic-bacteria
#14
Rahul Gaybarao Naik, Arun Suresh Dodamani, Mahesh Ravindra Khairnar, Harish Chaitram Jadhav, Manjiri Abhay Deshmukh
OBJECTIVES: Glass ionomer cements (GICs), which are biocompatible and adhesive to the tooth surface, are widely used nowadays for tooth restoration. They inhibit the demineralization and promote the remineralization of the tooth structure adjacent to the restoration, as well as interfere with bacterial growth. Hence, the present study was conducted to assess and compare the antimicrobial activity of three commercially available GICs against two cariogenic bacteria. MATERIALS AND METHODS: An agar plate diffusion test was used for evaluating the antimicrobial effect of three different GICs (Fuji IX, Ketac Molar, and d-tech) on Streptococcus mutans (S...
November 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27847746/elemental-analysis-of-caries-affected-root-dentin-and-artificially-demineralized-dentin
#15
Young-Hye Sung, Ho-Hyun Son, Keewook Yi, Juhea Chang
OBJECTIVES: This study aimed to analyze the mineral composition of naturally- and artificially-produced caries-affected root dentin and to determine the elemental incorporation of resin-modified glass ionomer (RMGI) into the demineralized dentin. MATERIALS AND METHODS: Box-formed cavities were prepared on buccal and lingual root surfaces of sound human premolars (n = 15). One cavity was exposed to a microbial caries model using a strain of Streptococcus mutans. The other cavity was subjected to a chemical model under pH cycling...
November 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27843252/a-comparative-evaluation-of-the-efficacy-of-different-caries-excavation-techniques-in-reducing-the-cariogenic-flora-an-in-vivo-study
#16
REVIEW
Afrah Fatima Hassan, Gunjan Yadav, Abhay Mani Tripathi, Mridul Mehrotra, Sonali Saha, Nishita Garg
BACKGROUND: Caries excavation is a noninvasive technique of caries removal with maximum preservation of healthy tooth structure. AIM: To compare the efficacy of three different caries excavation techniques in reducing the count of cariogenic flora. MATERIALS AND METHODS: Sixty healthy primary molars were selected from 26 healthy children with occlusal carious lesions without pulpal involvement and divided into three groups in which caries excavation was done with the help of (1) carbide bur; (2) polymer bur using slow-speed handpiece; and (3) ultrasonic tip with ultrasonic machine...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27843246/evaluation-and-comparison-of-the-antibacterial-activity-against-streptococcus-mutans-of-grape-seed-extract-at-different-concentrations-with-chlorhexidine-gluconate-an-in-vitro-study
#17
REVIEW
Milan Swadas, Bhavna Dave, Soham M Vyas, Nupur Shah
INTRODUCTION: Streptococcus mutans has been implicated as primary microorganisms which cause dental caries in humans. There has been an increased interest in the therapeutic properties of some medicinal plants and natural compounds which have demonstrated antibacterial activities. Grape is one of the plants of this group which contains tannin and polyphenolic compound. AIM: To evaluate and compare antibacterial activity of grape seed extract at different concentrations with chlorhexidine gluconate against S...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27837345/molecular-detection-of-bacteria-associated-to-caries-activity-in-dentinal-lesions
#18
Beatriz Gonçalves Neves, Rafael Nóbrega Stipp, Daniela da Silva Bezerra, Sarah Florindo de Figueiredo Guedes, Lidiany Karla Azevedo Rodrigues
OBJECTIVES: This study aimed at identifying and quantifying Actinomyces naeslundii, Bifidobacterium spp., Streptococcus mitis group, Lactobacillus acidophilus, Lactobacillus casei group, Streptococcus gordonii, and Streptococcus mutans in active and inactive carious dentine lesions of children with early childhood caries by using quantitative polymerase chain reaction. MATERIAL AND METHODS: Fifty-six dentin lesion samples, classified as active (n = 39) or inactive (n = 17), were collected from children aged from 2 to 5 years old...
November 12, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27833895/evaluation-of-antibacterial-activity-of-achyranthes-aspera-extract-against-streptococcus-mutans-an-in-vitro-study
#19
Roma Yadav, Radhika Rai, Abhishek Yadav, Meetika Pahuja, Savita Solanki, Himani Yadav
Dental caries and periodontal diseases have historically been considered the most important global oral health burdens. Many chemicals and synthetic drugs have marked the side effects. Hence, there has been a paradigm shift from the use of modern drugs to the age-old herbs. Achyranthes aspera is one such important plant with various established pharmaceutical properties. The aim of this study was to assess the antibacterial activity of the A. aspera extract against Streptococcus mutans. Aqueous extract of A...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833139/contributions-of-streptococcus-mutans-cnm-and-pa-antigens-to-aggravation-of-non-alcoholic-steatohepatitis-in-mice
#20
Shuhei Naka, Rina Hatakeyama, Yukiko Takashima, Michiyo Matsumoto-Nakano, Ryota Nomura, Kazuhiko Nakano
Streptococcus mutans, a major pathogen of dental caries, can cause infective endocarditis after invading the bloodstream. Recently, intravenous administration of specific S. mutans strains was shown to aggravate non-alcoholic steatohepatitis (NASH) in a mouse model fed a high-fat diet. Here, we investigated the mechanism of this aggravation in a NASH mouse model by focusing on the S. mutans cell surface collagen-binding protein (Cnm) and the 190-kDa protein antigen (PA). Mice that were intravenously administered a S...
November 11, 2016: Scientific Reports
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