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https://www.readbyqxmd.com/read/28315373/memory-for-objects-and-startle-responsivity-in-the-immediate-aftermath-of-exposure-to-the-trier-social-stress-test
#1
Nadja Herten, Dennis Pomrehn, Oliver T Wolf
Previously we observed enhanced long-term memory for objects used (central objects) by committee members in the Trier Social Stress Test (TSST) on the next day. In addition, startle responsivity was increased. However, response specificity to an odour involved in the stressful episode was lacking and recognition memory for the odour was poor. In the current experiments, immediate effects of the stressor on memory and startle responsivity were investigated. We hypothesised memory for central objects of the stressful episode and startle response specificity to an odour ambient during the TSST to be enhanced shortly after it in contrast to the control condition (friendly TSST)...
March 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28315340/in-vivo-pharmacological-profile-of-s-38093-a-novel-histamine-h3-receptor-inverse-agonist
#2
Fany Panayi, Aurore Sors, Lionel Bert, Brigitte Martin, Gaelle Rollin-Jego, Rodolphe Billiras, Isabelle Carrié, Karine Albinet, Laurence Danober, Nathalie Rogez, Jean-Yves Thomas, Luigi Pira, Valérie Bertaina-Anglade, Pierre Lestage
S 38093, a novel histamine H3 receptor inverse agonist, was tested in a series of neurochemical and behavioral paradigms designed to evaluate its procognitive and arousal properties. In intracerebral microdialysis studies performed in rats, S 38093 dose-dependently increased histamine extracellular levels in the prefrontal cortex and facilitated cholinergic transmission in the prefrontal cortex and hippocampus of rats after acute and chronic administration (10mg/kg i.p.). Acute oral administration of S 38093 at 0...
March 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28314160/difference-in-imaging-biomarkers-of-neurodegeneration-between-early-and-late-onset-amnestic-alzheimer-s-disease
#3
Anne-Laure Aziz, Bernard Giusiano, Sven Joubert, Lauréline Duprat, Mira Didic, Claude Gueriot, Lejla Koric, José Boucraut, Olivier Felician, Jean-Philippe Ranjeva, Eric Guedj, Mathieu Ceccaldi
Neuroimaging biomarkers differ between patients with early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD). Whether these changes reflect cognitive heterogeneity or differences in disease severity is still unknown. This study aimed at investigating changes in neuroimaging biomarkers, according to the age of onset of the disease, in mild amnestic Alzheimer's disease patients with positive amyloid biomarkers in cerebrospinal fluid. Both patient groups were impaired on tasks assessing verbal and visual recognition memory...
February 21, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28306349/utility-of-critical-items-within-the-recognition-memory-test-and-word-choice-test
#4
Laszlo A Erdodi, Bradley T Tyson, Christopher A Abeare, Brandon G Zuccato, Jaspreet K Rai, Kristian R Seke, Sanya Sagar, Robert M Roth
This study was designed to examine the clinical utility of critical items within the Recognition Memory Test (RMT) and the Word Choice Test (WCT). Archival data were collected from a mixed clinical sample of 202 patients clinically referred for neuropsychological testing (54.5% male; mean age = 45.3 years; mean level of education = 13.9 years). The credibility of a given response set was psychometrically defined using three separate composite measures, each of which was based on multiple independent performance validity indicators...
March 17, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28303965/effect-of-1-8%C3%A2-ghz-radiofrequency-electromagnetic-radiation-on-novel-object-associative-recognition-memory-in-mice
#5
Kai Wang, Jun-Mei Lu, Zhen-He Xing, Qian-Ru Zhao, Lin-Qi Hu, Lei Xue, Jie Zhang, Yan-Ai Mei
Mounting evidence suggests that exposure to radiofrequency electromagnetic radiation (RF-EMR) can influence learning and memory in rodents. In this study, we examined the effects of single exposure to 1.8 GHz RF-EMR for 30 min on subsequent recognition memory in mice, using the novel object recognition task (NORT). RF-EMR exposure at an intensity of >2.2 W/kg specific absorption rate (SAR) power density induced a significant density-dependent increase in NORT index with no corresponding changes in spontaneous locomotor activity...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303372/ellagic-acid-ameliorates-learning-and-memory-deficits-in-a-rat-model-of-alzheimer-s-disease-an-exploration-of-underlying-mechanisms
#6
Zahra Kiasalari, Rana Heydarifard, Mohsen Khalili, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Elham Zahedi, Ashkan Sanaierad, Mehrdad Roghani
RATIONALE: Alzheimer's disease (AD) is a neurodegenerative disorder with irreversible loss of intellectual abilities. Current therapies for AD are still insufficient. OBJECTIVE: In this study, the effect of ellagic acid on learning and memory deficits was evaluated in intrahippocampal amyloid beta (Aβ25-35)-microinjected rats and its modes of action were also explored. METHODS: AD rat model was induced by bilateral intrahippocampal microinjection of Aβ25-35 and ellagic acid was daily administered (10, 50, and 100 mg/kg), and learning, recognition memory, and spatial memory were evaluated in addition to histochemical assessment, oxidative stress, cholinesterases activity, and level of nuclear factor-kappaB (NF-κB), Toll-like receptor 4 (TLR4), and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)...
March 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28302196/-association-between-intelligence-development-and-facial-expression-recognition-ability-in-children-with-autism-spectrum-disorder
#7
Ning Pan, Gui-Hua Wu, Ling Zhang, Ya-Fen Zhao, Han Guan, Cai-Juan Xu, Jin Jing, Yu Jin
OBJECTIVE: To investigate the features of intelligence development, facial expression recognition ability, and the association between them in children with autism spectrum disorder (ASD). METHODS: A total of 27 ASD children aged 6-16 years (ASD group, full intelligence quotient >70) and age- and gender-matched normally developed children (control group) were enrolled. Wechsler Intelligence Scale for Children Fourth Edition and Chinese Static Facial Expression Photos were used for intelligence evaluation and facial expression recognition test...
March 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28302161/cognitive-profile-in-prodromal-dementia-with-lewy-bodies
#8
Jennifer Kemp, Nathalie Philippi, Clélie Phillipps, Catherine Demuynck, Timothée Albasser, Catherine Martin-Hunyadi, Catherine Schmidt-Mutter, Benjamin Cretin, Frédéric Blanc
BACKGROUND: Cortical and subcortical cognitive impairments have been found in dementia with Lewy bodies (DLB). Roughly, they comprise visuoconstructive and executive dysfunction, whereas memory would remain relatively spared. However, the cognitive profile of patients with prodromal DLB remains poorly illustrated to date. METHODS: We included 37 patients with prodromal DLB (age 67.2 ± 8.6 years, 18 men, Mini Mental State Examination [MMSE] score 27.4 ± 2) and 29 healthy control subjects (HCs; age 68...
March 16, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28301185/embodied-memory-allows-accurate-and-stable-perception-of-hidden-objects-despite-orientation-change
#9
Jing Samantha Pan, Ned Bingham, Geoffrey P Bingham
Rotating a scene in a frontoparallel plane (rolling) yields a change in orientation of constituent images. When using only information provided by static images to perceive a scene after orientation change, identification performance typically decreases (Rock & Heimer, 1957). However, rolling generates optic flow information that relates the discrete, static images (before and after the change) and forms an embodied memory that aids recognition. The embodied memory hypothesis predicts that upon detecting a continuous spatial transformation of image structure, or in other words, seeing the continuous rolling process and objects undergoing rolling observers should accurately perceive objects during and after motion...
March 16, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28294340/neuroprotective-effects-of-artemisinin-against-isoflurane-induced-cognitive-impairments-and-neuronal-cell-death-involve-jnk-erk1-2-signalling-and-improved-hippocampal-histone-acetylation-in-neonatal-rats
#10
Guang Xu, Yun-Li Huang, Ping-le Li, Hai-Ming Guo, Xue-Ping Han
OBJECTIVE: This study was performed to assess the effect of artemisinin against isoflurane-induced neuronal apoptosis and cognitive impairment in neonatal rats. METHODS: Artemisinin (50, 100 or 200 mg/kg b.wt/day; oral gavage) was administered to separate groups of neonatal rats starting from postnatal day 3 (P3) to postnatal day 21 (P21). On postnatal day 7 (P7), animals were exposed to inhalation anaesthetic isoflurane (0.75%) for 6 h. KEY FINDINGS: Neuronal apoptosis following anaesthetic exposure was significantly reduced by artemisinin...
March 12, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28294132/5-ht2c-agonists-modulate-schizophrenia-like-behaviors-in-mice
#11
Vladimir M Pogorelov, Ramona M Rodriguiz, Jianjun Cheng, Mei Huang, Claire M Schmerberg, Herbert Y Meltzer, Bryan L Roth, Alan P Kozikowski, William C Wetsel
All FDA-approved antipsychotic drugs (APDs) target primarily dopamine D2 or serotonin (5-HT2A) receptors, or both; however, these medications are not universally effective, they may produce undesirable side-effects, and provide only partial amelioration of negative and cognitive symptoms. The heterogeneity of pharmacological responses in schizophrenic patients suggests additional drug-targets may be effective in improving aspects of this syndrome. Recent evidence suggests that 5-HT2C receptors may be a promising target for schizophrenia since their activation reduces mesolimbic nigrostriatal dopamine release (which conveys antipsychotic action), they are expressed almost exclusively in CNS, and have weight-loss promoting capabilities...
March 15, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28293729/altered-cortico-striatal-crosstalk-underlies-object-recognition-memory-deficits-in-the-sub-chronic-phencyclidine-model-of-schizophrenia
#12
Aman Asif-Malik, Daniel Dautan, Andrew M J Young, Todor V Gerdjikov
The neural mechanisms underlying cognitive deficits in schizophrenia are poorly understood. Sub-chronic treatment with the NMDA antagonist phencyclidine (PCP) produces cognitive abnormalities in rodents that reliably model aspects of the neurocognitive alterations observed in schizophrenia. Given that network activity across regions encompassing medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) plays a significant role in motivational and cognitive tasks, we measured activity across cortico-striatal pathways in PCP-treated rats to characterize neural enabling and encoding of task performance in a novel object recognition task...
March 14, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28292834/functional-connectivity-of-multiple-brain-regions-required-for-the-consolidation-of-social-recognition-memory
#13
Toshiyuki Tanimizu, Justin W Kenney, Emiko Okano, Kazune Kadoma, Paul W Frankland, Satoshi Kida
Social recognition memory is an essential and basic component of social behavior to discriminate familiar and novel animals/humans. Previous studies have shown the importance of several brain regions for social recognition memories; however, the mechanisms underlying the consolidation of social recognition memory at the molecular and anatomic levels remain unknown. Here, we show a brain network necessary for the generation of social recognition memory in mice. A mouse genetic study showed that cAMP-responsive element-binding protein (CREB)-mediated transcription is required for the formation of social recognition memory...
March 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28292217/influence-of-social-anxiety-on-recognition-memory-for-happy-and-angry-faces-comparison-between-own-and-other-race-faces
#14
Mariko Kikutani
The reported experiment investigated memory of unfamiliar faces and how it is influenced by race, facial expression, direction of gaze, and observers' level of social anxiety. Eighty- seven Japanese participants initially memorized images of Oriental and Caucasian faces displaying either happy or angry expressions with direct or averted gaze. They then saw the previously seen faces and additional distractor faces displaying neutral expressions, and judged if they had seen them before. Their level of social anxiety was measured with a questionnaire...
March 15, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28291777/adolescent-but-not-adult-ethanol-binge-drinking-modulates-cocaine-withdrawal-symptoms-in-mice
#15
Juan Carlos Ledesma, Maria A Aguilar, Pablo Giménez-Gómez, José Miñarro, Marta Rodríguez-Arias
BACKGROUND: Ethanol (EtOH) binge drinking is an increasingly common behavior among teenagers that induces long-lasting neurobehavioral alterations in adulthood. An early history of EtOH abuse during adolescence is highly correlated with cocaine addiction in adulthood. Abstinence of cocaine abuse can cause psychiatric symptoms, such as anxiety, psychosis, depression, and cognitive impairments. This study assessed the consequences of adolescent exposure to EtOH on the behavioral alterations promoted by cocaine withdrawal in adulthood...
2017: PloS One
https://www.readbyqxmd.com/read/28289940/the-effect-of-hippocampal-function-volume-and-connectivity-on-posterior-cingulate-cortex-functioning-during-episodic-memory-fmri-in-mild-cognitive-impairment
#16
Janne M Papma, Marion Smits, Marius de Groot, Francesco U Mattace Raso, Aad van der Lugt, Henri A Vrooman, Wiro J Niessen, Peter J Koudstaal, John C van Swieten, Frederik M van der Veen, Niels D Prins
OBJECTIVES: Diminished function of the posterior cingulate cortex (PCC) is a typical finding in early Alzheimer's disease (AD). It is hypothesized that in early stage AD, PCC functioning relates to or reflects hippocampal dysfunction or atrophy. The aim of this study was to examine the relationship between hippocampus function, volume and structural connectivity, and PCC activation during an episodic memory task-related fMRI study in mild cognitive impairment (MCI). METHOD: MCI patients (n = 27) underwent episodic memory task-related fMRI, 3D-T1w MRI, 2D T2-FLAIR MRI and diffusion tensor imaging...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28289600/conflict-processing-in-juvenile-patients-with-neurofibromatosis-type-1-nf1-and-healthy-controls-two-pathways-to-success
#17
Annet Bluschke, Maja von der Hagen, Katharina Papenhagen, Veit Roessner, Christian Beste
Neurofibromatosis Type 1 (NF1) is a monogenetic autosomal-dominant disorder with a broad spectrum of clinical symptoms and is commonly associated with cognitive deficits. Patients with NF1 frequently exhibit cognitive impairments like attention problems, working memory deficits and dysfunctional inhibitory control. The latter is also relevant for the resolution of cognitive conflicts. However, it is unclear how conflict monitoring processes are modulated in NF1. To examine this question in more detail, we used a system neurophysiological approach combining high-density ERP recordings with source localisation analyses in juvenile patients with NF1 and controls during a flanker task...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28288948/memory-and-depressive-effect-on-male-and-female-swiss-mice-exposed-to-tannery-effluent
#18
Abraão Tiago Batista Guimarães, Raíssa de Oliveira Ferreira, Aline Sueli de Lima Rodrigues, Guilherme Malafaia
Although tannery industries generate substantial profits to the countries they are located in, they work with one of the most environmentally harmful human activities. Tannery effluents (TE) are highly toxic; thus, their improper release into water bodies may cause severe problems to individuals depending on this water. Therefore, the aim of the current study is to assess the effects of oral exposure to TE on the anxiety-, memory deficit- and depression-predictive behaviors in male and female Swiss adult mice...
March 10, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28287764/pushing-typists-back-on-the-learning-curve-memory-chunking-improves-retrieval-of-prior-typing-episodes
#19
Motonori Yamaguchi, James M Randle, Thomas L Wilson, Gordon D Logan
Hierarchical control of skilled performance depends on chunking of several lower-level units into a single higher-level unit. The present study examined the relationship between chunking and recognition of trained materials in the context of typewriting. In 3 experiments, participants were trained with typing nonwords and were later tested on their recognition of the trained materials. In Experiment 1, participants typed the same words or nonwords in 5 consecutive trials while performing a concurrent memory task...
March 13, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28287047/how-nursing-home-residents-with-dementia-respond-to-the-interactive-art-installation-venster-a-pilot-study
#20
Tom Luyten, Susy Braun, Gaston Jamin, Susan van Hooren, Luc de Witte
The goal of this study was (1) to determine whether and how nursing home residents with dementia respond to the interactive art installation in general and (2) to identify whether responses change when the content type and, therefore, the nature of the interaction with the artwork changes. The interactive art installation 'VENSTER' evokes responses in nursing home residents with dementia, illustrating the potential of interactive artworks in the nursing home environment. Frequently observed responses were naming, recognizing or asking questions about depicted content and how the installation worked, physically gesturing towards or tapping on the screen and tapping or singing along to the music...
March 12, 2017: Disability and Rehabilitation. Assistive Technology
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