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recognition memory

Elvira Boere, Astrid M Kamperman, Arianne E van 't Hoog, Walter W van den Broek, Tom K Birkenhäger
Electroconvulsive therapy (ECT) is considered an effective treatment for major depression with melancholic features. However, neurocognitive side-effects such as anterograde amnesia still regularly occur. The present study aims to evaluate the severity and course of anterograde amnesia in severely depressed patients undergoing ECT. In a prospective naturalistic study, anterograde memory function was assessed among inpatients who underwent ECT (n = 11). Subjects met DSM-IV criteria for major depressive disorder...
2016: PloS One
Neila Maria R de Lima, Emerson de O Ferreira, Mara Yone S D Fernandes, Francisco Arnaldo V de Lima, Kelly Rose T Neves, Marta Regina S do Carmo, Geanne M de Andrade
Inflammation plays a pivotal role in the development of ischemic brain damage. Astrocyte activation promotes the production of several proinflammatory mediators, such as TNF-α and iNOS. Eventually, neuronal death occurs, leading to the development of motor and memory deficits in patients. Boldine is the main alkaloid in the leaves and bark of the Peumus boldus Molina, and has anti-inflammatory and antioxidant properties. The aim of this work was to investigate the neuroprotective effect of boldine on neuroinflammation and memory deficits induced by permanent middle cerebral artery occlusion (pMCAO) in mice...
October 19, 2016: Behavioural Pharmacology
Rosemary Fama, Edith V Sullivan, Stephanie A Sassoon, Adolf Pfefferbaum, Natalie M Zahr
BACKGROUND: Executive functioning and episodic memory impairment occur in HIV infection (HIV) and chronic alcoholism (ALC). Comorbidity of these conditions (HIV + ALC) is prevalent and heightens risk of vulnerability to separate and compounded deficits. Age and disease-related variables can also serve as mediators of cognitive impairment and should be considered, given the extended longevity of HIV-infected individuals in this era of improved pharmacological therapy. METHODS: HIV, ALC, HIV + ALC, and normal controls (NC) were administered traditional and computerized tests of executive function and episodic memory...
October 19, 2016: Alcoholism, Clinical and Experimental Research
Ji-Won Lee, Bill X Huang, HeungSun Kwon, Md Abdur Rashid, Giorgi Kharebava, Abhishek Desai, Samarjit Patnaik, Juan Marugan, Hee-Yong Kim
Docosahexaenoic acid (DHA, 22:6n-3) is an omega-3 fatty acid essential for proper brain development. N-docosahexaenoylethanolamine (synaptamide), an endogenous metabolite of DHA, potently promotes neurogenesis, neuritogenesis and synaptogenesis; however, the underlying molecular mechanism is not known. Here, we demonstrate orphan G-protein coupled receptor 110 (GPR110, ADGRF1) as the synaptamide receptor, mediating synaptamide-induced bioactivity in a cAMP-dependent manner. Mass spectrometry-based proteomic characterization and cellular fluorescence tracing with chemical analogues of synaptamide reveal specific binding of GPR110 to synaptamide, which triggers cAMP production with low nM potency...
October 19, 2016: Nature Communications
R John Sawyer, S Marc Testa, Moira Dux
OBJECTIVE: Various research studies and neuropsychology practice organizations have reiterated the importance of developing embedded performance validity tests (PVTs) to detect potentially invalid neurocognitive test data. This study investigated whether measures within the Hopkins Verbal Learning Test - Revised (HVLT-R) and the Brief Visuospatial Memory Test - Revised (BVMT-R) could accurately classify individuals who fail two or more PVTs during routine clinical assessment. METHOD: The present sample of 109 United States military veterans (Mean age = 52...
October 19, 2016: Clinical Neuropsychologist
Steve D Charman, Andrea Reyes, Daniella K Villalba, Jacqueline R Evans
Some innocent suspects rely on the memory of strangers to corroborate their alibis. However, no research has examined whether such potential alibi corroborators can accurately recognize an innocent suspect with whom they previously interacted. We developed a novel alibi corroboration paradigm in which undergraduate students (representing innocent suspects who would later provide an alibi) interacted with naïve university employees (representing potential alibi corroborators). Each student briefly interacted with a different naïve university employee (n = 60), and were also each yoked to a different employee with whom they did not interact (n = 60)...
October 19, 2016: Behavioral Sciences & the Law
María Díez-Cirarda, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, Olaia Lucas-Jiménez, Juan Carlos Gómez-Esteban, Maria Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson's disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy)...
October 18, 2016: Brain Imaging and Behavior
Changtae Hahn, Chang-Uk Lee, Wang Yeon Won, Soo-Hyun Joo, Hyun Kook Lim
OBJECTIVE: This study aimed to investigate thalamic shape alterations and their relationships with various episodic memory impairments in subjects with amnestic mild cognitive impairment (aMCI). METHODS: We compared volumes and morphological alterations of the thalamus between aMCI subjects and healthy controls. In addition, we investigated the correlation between thalamic deformations and various memory impairments in aMCI subjects using a comprehensive neuropsychological battery...
September 2016: Psychiatry Investigation
Bettina K Steiger, Hennric Jokeit
Social bonds are at the center of our daily living and are an essential determinant of our quality of life. In people with epilepsy, numerous factors can impede cognitive and affective functions necessary for smooth social interactions. Psychological and psychiatric complications are common in epilepsy and may hinder the processing of social information. In addition, neuropsychological deficits such as slowed processing speed, memory loss or attentional difficulties may interfere with enjoyable reciprocity of social interactions...
October 11, 2016: Seizure: the Journal of the British Epilepsy Association
Andresa H Betti, Camila B Antonio, Thais E T Pompeu, Thaise S Martins, Vivian Herzfeldt, Eveline D Stolz, Carlos A M Fraga, Eliezer Barreiro, François Noël, Stela M K Rates
Aiming to identify new antipsychotic lead-compounds, our group has been working on the design and synthesis of new N-phenylpiperazine derivatives. Here, we characterized LASSBio-1422 as a pharmacological prototype of this chemical series. Adult male Wistar rats and CF1 mice were used for in-vitro and in-vivo assays, respectively. LASSBio-1422 [1 and 5 mg/kg, postoperatively (p.o.)] inhibited apomorphine-induced climbing as well as ketamine-induced hyperlocomotion (1 and 5 mg/kg, p.o.), animal models predictive of efficacy on positive symptoms...
October 13, 2016: Behavioural Pharmacology
Maria Teresa Turano, Maria Pia Viggiano
The relationship between face recognition ability and socioemotional functioning has been widely explored. However, how aging modulates this association regarding both objective performance and subjective-perception is still neglected. Participants, aged between 18 and 81 years, performed a face memory test and completed subjective face recognition and socioemotional questionnaires. General and social anxiety, and neuroticism traits account for the individual variation in face recognition abilities during adulthood...
October 18, 2016: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Adam I Ramsaran, Hollie R Sanders, Mark E Stanton
Since the seminal report on novel object recognition in the rat (Ennaceur & Delacour, 1988), novelty recognition paradigms have become increasingly prevalent in learning and memory research. Novelty recognition tasks do not require extensive training or complex behaviors, and thus are especially suitable for studying the ontogeny of various forms of memory (e.g., object, spatial, and contextual memory). However, relatively little is known about the determinants of recognition memory during development. The present study extends our recent research on the development of recognition memory by further characterizing the ontogeny of contextual recognition (Ramsaran, Westbrook, & Stanton, 2016)...
November 2016: Developmental Psychobiology
Harlene Hayne, Katja Jaeger, Trine Sonne, Julien Gross
The visual recognition memory (VRM) paradigm has been widely used to measure memory during infancy and early childhood; it has also been used to study memory in human and nonhuman adults. Typically, participants are familiarized with stimuli that have no special significance to them. Under these conditions, greater attention to the novel stimulus during the test (i.e., novelty preference) is used as the primary index of memory. Here, we took a novel approach to the VRM paradigm and tested 1-, 2-, and 3-year olds using photos of meaningful stimuli that were drawn from the participants' own environment (e...
November 2016: Developmental Psychobiology
Claudia Balducci, Angelisa Frasca, Margherita Zotti, Pietro La Vitola, Emanuela Mhillaj, Emanuele Grigoli, Martina Iacobellis, Federica Grandi, Massimo Messa, Laura Colombo, Monica Molteni, Luigia Trabace, Carlo Rossetti, Mario Salmona, Gianluigi Forloni
[Background] Amyloid-β oligomers (AβO) are species mainly involved in the synaptic and cognitive dysfunction in Alzheimer's disease. Although their action has been described mainly at neuronal level, it is now clear that glial cells govern synaptic activity in their resting state, contributing to new learning and memory establishment. In contrast, when activated, they may lead to synaptic and cognitive dysfunction. Using a reliable acute AβO-mediated mouse model of AD, we explored whether the memory alteration AβOs induce relies on the activation of glial cells, and if Toll-like receptor 4 (TLR4), pivotal in the initiation of an immune response, is involved...
October 14, 2016: Brain, Behavior, and Immunity
Clive R Rosenthal, David Soto
Cortical regions as early as primary visual cortex have been implicated in recognition memory. Here, we outline the challenges that this presents for neurobiological accounts of recognition memory. We conclude that understanding the role of early visual cortex (EVC) in this process will require the use of protocols that mask stimuli from visual awareness.
October 14, 2016: Trends in Neurosciences
Nicola Jones, Leigh M Riby, Michael A Smith
BACKGROUND AND AIMS: Older adults with type 2 diabetes mellitus (DM2) exhibit accelerated decline in some domains of cognition including verbal episodic memory. Few studies have investigated the influence of DM2 status in older adults on recognition memory for more complex stimuli such as faces. In the present study we sought to compare recognition memory performance for words, objects and faces under conditions of relatively low and high cognitive load. METHODS: Healthy older adults with good glucoregulatory control (n = 13) and older adults with DM2 (n = 24) were administered recognition memory tasks in which stimuli (faces, objects and words) were presented under conditions of either i) low (stimulus presented without a background pattern) or ii) high (stimulus presented against a background pattern) cognitive load...
July 2016: Archives of Medical Research
Madeleine M Uys, Mohammed Shahid, Jukka Sallinen, Brian H Harvey
Depression involves deficits in monoaminergic neurotransmission. Differential roles for α2A, B and C subtypes of the α2-adrenoceptor (AR) are evident, with selective α2C-AR antagonists purported to have antidepressant and procognitive properties. However, this has not been demonstrated in a genetic animal model of depression. The role of the α2C-AR in modulating two key depression-related behaviours in the Flinders Sensitive Line (FSL) rat was studied using a dose-response analysis following subcutaneous administration with the selective α2C-AR antagonist ORM-10921 (0...
September 30, 2016: Behavioural Pharmacology
Pierre Bordaberry, Christian Gerlach, Quentin Lenoble
: Background/Study Context: The objective of this study was to investigate the object recognition deficit in aging. Age-related declines were examined from the presemantic account of category effects (PACE) theory perspective (Gerlach, 2009, Cognition, 111, 281-301). This view assumes that the structural similarity/dissimilarity inherent in living and nonliving objects, respectively, can account for a wide range of category-specific effects. METHODS: In two experiments on object recognition, young (36 participants, 18-27 years) and older (36 participants, 53-69 years) adult participants' performances were compared...
October 2016: Experimental Aging Research
Aurélia Bugaiska, Alain Méot, Patrick Bonin
: Background/Study Context: It has been found that young adults remember animates better than inanimates. According to the adaptive view of human memory, this is due to the fact that animates are more important for fitness purposes than inanimates. This effect has been ascribed to episodic memory, where older people exhibit difficulties. METHODS: Here the authors investigated whether the animacy effect in memory also occurs for healthy older adults. Older and young adults categorized words for their animacy characteristics and were then given an unexpected recognition test on the words using the Remember/Know paradigm...
October 2016: Experimental Aging Research
Michael J Armson, Hervé Abdi, Brian Levine
Autobiographical memory tests provide a naturalistic counterpoint to the artificiality of laboratory research methods, yet autobiographical events are uncontrolled and, in most cases, unverifiable. In this study, we capitalised on a scripted, complex naturalistic event - the mask fit test (MFT), a standardised procedure required of hospital employees - to bridge the gap between naturalistic and laboratory memory assessment. We created a test of recognition memory for the MFT and administered it to 135 hospital employees who had undertaken the MFT at various points over the past five years...
October 17, 2016: Memory
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