keyword
MENU ▼
Read by QxMD icon Read
search

perirhinal cortex

keyword
https://www.readbyqxmd.com/read/28528847/independent-contributions-of-fmri-familiarity-and-novelty-effects-to-recognition-memory-and-their-stability-across-the-adult-lifespan
#1
Marianne de Chastelaine, Julia T Mattson, Tracy H Wang, Brian E Donley, Michael D Rugg
The impact of age on the neural correlates of familiarity-driven recognition memory has received relatively little attention. Here, the relationships between age, the neural correlates of familiarity, and memory performance were investigated using an associative recognition test in young, middle-aged and older participants. Test items comprised studied, rearranged (items studied on different trials) and new word pairs. fMRI 'familiarity effects' were operationalized as greater activity for studied test pairs incorrectly identified as 'rearranged' than for correctly rejected new pairs...
May 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28488186/functional-organization-of-the-medial-temporal-lobe-memory-system-following-neonatal-hippocampal-lesion-in-rhesus-monkeys
#2
Loïc J Chareyron, Pamela Banta Lavenex, David G Amaral, Pierre Lavenex
Hippocampal damage in adult humans impairs episodic and semantic memory, whereas hippocampal damage early in life impairs episodic memory but leaves semantic learning relatively preserved. We have previously shown a similar behavioral dissociation in nonhuman primates. Hippocampal lesion in adult monkeys prevents allocentric spatial relational learning, whereas spatial learning persists following neonatal lesion. Here, we quantified the number of cells expressing the immediate-early gene c-fos, a marker of neuronal activity, to characterize the functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion...
May 9, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28484388/aging-impairs-hippocampal-dependent-recognition-memory-and-ltp-and-prevents-the-associated-ryr-up-regulation
#3
Alejandra Arias-Cavieres, Tatiana Adasme, Gina Sánchez, Pablo Muñoz, Cecilia Hidalgo
Recognition memory comprises recollection judgment and familiarity, two different processes that engage the hippocampus and the perirhinal cortex, respectively. Previous studies have shown that aged rodents display defective recognition memory and alterations in hippocampal synaptic plasticity. We report here that young rats efficiently performed at short-term (5 min) and long-term (24 h) hippocampus-associated object-location tasks and perirhinal cortex-related novel-object recognition tasks. In contrast, aged rats successfully performed the object-location and the novel-object recognition tasks only at short-term...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28473640/anterolateral-entorhinal-cortex-volume-predicted-by-altered-intra-item-configural-processing
#4
Lok-Kin Yeung, Rosanna K Olsen, Hannah E P Bild-Enkin, Maria C D'Angelo, Arber Kacollja, Douglas A McQuiggan, Anna Keshabyan, Jennifer D Ryan, Morgan D Barense
Recent functional imaging studies have proposed that the human entorhinal cortex is subdivided into functionally distinct anterolateral (alERC) and posteromedial (pmERC) subregions. The alERC overlaps with regions that are affected earliest by Alzheimer's disease pathology, yet its cognitive function remains poorly understood. Previous human fMRI studies have focused on its role in object memory, but rodent studies on the putatively homologous lateral entorhinal cortex suggest that it also plays an important role in representing spatial properties of objects...
May 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28456521/visual-integration-enhances-associative-memory-equally-for-young-and-older-adults-without-reducing-hippocampal-encoding-activation
#5
Molly Memel, Lee Ryan
The ability to remember associations between previously unrelated pieces of information is often impaired in older adults (Naveh-Benjamin, 2000). Unitization, the process of creating a perceptually or semantically integrated representation that includes both items in an associative pair, attenuates age-related associative deficits (Bastin et al., 2013; Ahmad et al., 2015; Zheng et al., 2015). Compared to non-unitized pairs, unitized pairs may rely less on hippocampally-mediated binding associated with recollection, and more on familiarity-based processes mediated by perirhinal cortex (PRC) and parahippocampal cortex (PHC)...
April 26, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28444371/neural-correlates-of-both-perception-and-memory-for-objects-in-the-rodent-perirhinal-cortex
#6
Jae-Rong Ahn, Inah Lee
Despite its anatomical positioning as an interface between the perceptual and memory systems, the perirhinal cortex (PER) has long been considered dedicated for object recognition memory. Whether the PER is also involved in object perception has been intensely debated in recent studies, but physiological evidence has been lacking. We recorded single units from the PER while the rat made categorical responses immediately after sampling a visual object as the originally learned objects were ambiguously morphed to varying degrees...
April 24, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28424398/-brodmann-areas-27-28-36-and-37-the-parahippocampal-and-the-fusiform-gyri
#7
Satoshi Eifuku
First, Brodmann areas 27, 28, 36 and 37, were anatomically defined in the beginning of this review. These areas exist in the parahippocampal or fusiform gyrus of the ventral temporal lobe in humans. Subsequently, the current understanding of their functions was summarized on the basis of recent findings mainly through human functional neuroimaging studies and animal studies. Rodent studies have shown the existence of neuronal activities for representing space, such as those involving head-direction cells or grid cells, in areas 27 (the parasubicular cortex) and 28 (the ventral entorhinal cortex)...
April 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28424397/-spatial-cognition-and-episodic-memory-formation-in-the-limbic-cortex
#8
Yasushi Kobayashi
The limbic lobe defined by Broca is a cortical region with highly diverse structure and functions, and comprises the paleo-, archi-, and neocortices as well as their transitional zones. In the limbic lobe, Brodmann designated areas 27, 28, 34, 35, and 36 adjacent to the hippocampus, and areas 23, 24, 25, 26, 29, 30, 31, 32, and 33 around the corpus callosum. In the current literature, areas 27 and 28 correspond to the presubiculum and entorhinal cortex, respectively. Area 34 represents the cortico-medial part of the amygdaloid complex...
April 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28419566/perirhinal-accumulation-of-neuronal-alpha-synuclein-in-a-multiple-system-atrophy-patient-with-dementia
#9
Mari Saito, Makoto Hara, Momoko Ebashi, Akihiko Morita, Kyoko Okada, Taku Homma, Masahiko Sugitani, Kentaro Endo, Toshiki Uchihara, Satoshi Kamei
We report the case of a 79-year-old Japanese woman who developed cerebellar ataxia followed by rigidity, dysautonomia and cognitive disorders, and was thus clinically diagnosed as having possible MSA with dementia. Neuropathological findings demonstrated not only olivopontocerebellar and striatonigral degeneration with frequent glial cytoplasmic inclusions (GCIs), but also degenerative changes in the parahippocampal region, accentuated in the anterior portion of perirhinal cortex, where neuronal cytoplasmic inclusions (NCIs) and NFTs were numerous while GCIs were limited...
April 16, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28411272/disconnection-of-the-perirhinal-and-postrhinal-cortices-impairs-recognition-of-objects-in-context-but-not-contextual-fear-conditioning
#10
Victoria R Heimer-McGinn, Devon L Poeta, Krishan Aghi, Methma Udawatta, Rebecca D Burwell
The perirhinal cortex (PER) is known to process object information, whereas the rodent postrhinal cortex (POR), homolog to the parahippocampal cortex in primates, is thought to process spatial information. A number of studies, however, provide evidence that both areas are involved in processing contextual information. In this study, we tested the hypothesis that the rat POR relies on object information received from the PER to form complex representations of context. Using three fear-conditioning (FC) paradigms (signaled, unsignaled, and renewal) and two context-guided object recognition tasks (with 3D and 2D objects), we examined the effects of crossed excitotoxic lesions to the POR and the contralateral PER...
May 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28389337/recognition-memory-induced-gene-expression-in-the-perirhinal-cortex-a-transcriptomic-analysis
#11
Hannah Scott, Mark F Rogers, Helen L Scott, Colin Campbell, Elizabeth C Warburton, James B Uney
We have used transcriptome analysis to identify genes and pathways that are activated during recognition memory formation in the perirhinal cortex. Rats were exposed to objects either repeatedly, so that the objects become familiar, or to novel objects in a bow-tie maze over six consecutive days. On the final day, one hour after the last exposure to the series of objects, RNA from the perirhinal cortex was sequenced to compare the transcriptome of naïve control rats and rats exposed to either novel or familiar stimuli...
April 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28367410/contrasting-roles-for-dna-methyltransferases-and-histone-deacetylases-in-single-item-and-associative-recognition-memory
#12
Hannah Scott, Anna E Smith, Gareth R Barker, James B Uney, E Clea Warburton
Recognition memory enables us to judge whether we have encountered a stimulus before and to recall associated information, including where the stimulus was encountered. The perirhinal cortex (PRh) is required for judgment of stimulus familiarity, while hippocampus (HPC) and medial prefrontal cortex (mPFC) are additionally involved when spatial information associated with a stimulus needs to be remembered. While gene expression is known to be essential for the consolidation of long-term recognition memory, the underlying regulatory mechanisms are not fully understood...
March 2017: Neuroepigenetics
https://www.readbyqxmd.com/read/28347878/memory-guided-drawing-training-increases-granger-causal-influences-from-the-perirhinal-cortex-to-v1-in-the-blind
#13
Laura Cacciamani, Lora T Likova
The perirhinal cortex (PRC) is a medial temporal lobe structure that has been implicated in not only visual memory in the sighted, but also tactile memory in the blind (Cacciamani & Likova, 2016). It has been proposed that, in the blind, the PRC may contribute to modulation of tactile memory responses that emerge in low-level "visual" area V1 as a result of training-induced cortical reorganization (Likova, 2012, 2015). While some studies in the sighted have indicated that the PRC is indeed structurally and functionally connected to the visual cortex (Clavagnier, Falchier, & Kennedy, 2004; Peterson, Cacciamani, Barense, & Scalf, 2012), the PRC's direct modulation of V1 is unknown-particularly in those who lack the visual input that typically stimulates this region...
March 24, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28342259/rodent-age-related-impairments-in-discriminating-perceptually-similar-objects-parallel-those-observed-in-humans
#14
Sarah A Johnson, Sean M Turner, Lindsay A Santacroce, Katelyn N Carty, Leila Shafiq, Jennifer L Bizon, Andrew P Maurer, Sara N Burke
The ability to accurately remember distinct episodes is supported by high-level sensory discrimination. Performance on mnemonic similarity tasks, which test high-level discrimination, declines with advancing age in humans and these deficits have been linked to altered activity in hippocampal CA3 and dentate gyrus. Lesion studies in animal models, however, point to the perirhinal cortex as a brain region critical for sensory discriminations that serve memory. Reconciliation of the contributions of different regions within the cortical-hippocampal circuit requires the development of a discrimination paradigm comparable to the human mnemonic similarity task that can be used in rodents...
March 25, 2017: Hippocampus
https://www.readbyqxmd.com/read/28340966/recognition-memory-is-selectively-impaired-in-adult-rats-exposed-to-binge-like-doses-of-ethanol-during-early-postnatal-life
#15
Nicole M MacIlvane, Joseph M Pochiro, Nicole R Hurwitz, Molly J Goodfellow, Derick H Lindquist
Exposure to alcohol in utero can induce a variety of physical and mental impairments, collectively known as fetal alcohol spectrum disorders (FASD). This study explores the persistent cognitive consequences of ethanol administration in rat pups over postnatal days (PD) 4-9, modeling human third trimester consumption. Between PD65-70, ethanol-exposed (5E) and control rats were evaluated in two variants of recognition memory, the spontaneous novel object recognition (NOR) task, using 20 and 240 min sample-to-test delays, and the associative object-in-context (OIC) task, using a 20 min delay...
December 2016: Alcohol
https://www.readbyqxmd.com/read/28304286/family-history-of-alzheimer-s-disease-is-associated-with-impaired-perceptual-discrimination-of-novel-objects
#16
Emily J Mason, Erin P Hussey, Robert J Molitor, Philip C Ko, Manus J Donahue, Brandon A Ally
Early detection may be the key to developing therapies that will combat Alzheimer's disease (AD). It has been consistently demonstrated that one of the main pathologies of AD, tau, is present in the brain decades before a clinical diagnosis. Tau pathology follows a stereotypical route through the medial temporal lobe beginning in the entorhinal and perirhinal cortices. If early pathology leads to very subtle changes in behavior, it may be possible to detect these changes in subjects years before a clinical diagnosis can currently be made...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28289278/cafeteria-diet-and-probiotic-therapy-cross-talk-among-memory-neuroplasticity-serotonin-receptors-and-gut-microbiota-in-the-rat
#17
J E Beilharz, N O Kaakoush, J Maniam, M J Morris
The western diet is known to have detrimental effects on cognition and the gut microbiota, but few studies have investigated how these may be related. Here, we examined whether a probiotic could prevent diet-induced memory deficits. Rats were pre-exposed to vehicle, low or high doses of VSL#3 for 2 weeks before half were switched from chow to a cafeteria diet (Caf) for 25 days; VSL#3 treatment continued until death. High-dose VSL#3 prevented the diet-induced memory deficits on the hippocampal-dependent place task, but the probiotic caused deficits on the perirhinal-dependent object task, irrespective of diet or dose...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28236751/perirhinal-cortex-tracks-degree-of-recent-as-well-as-cumulative-lifetime-experience-with-object-concepts
#18
Devin Duke, Chris B Martin, Ben Bowles, Ken McRae, Stefan Köhler
Evidence from numerous sources indicates that recognition of the prior occurrence of objects requires computations of perirhinal cortex (PrC) in the medial temporal lobe. Extant research has primarily probed recognition memory based on item exposure in a recent experimental study episode. Outside the laboratory, however, familiarity for objects typically accrues gradually with learning across many different episodic contexts, which can be distributed over a lifetime of experience. It is currently unknown whether PrC also tracks this cumulative lifetime experience with object concepts...
January 31, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28169319/early-life-stress-impairs-recognition-memory-and-perturbs-the-functional-maturation-of-prefrontal-hippocampal-perirhinal-networks
#19
Samuel A J Reincke, Ileana L Hanganu-Opatz
Early life exposure to stressful situations impairs cognitive performance of adults and contributes to the etiology of several psychiatric disorders. Most of affected cognitive abilities rely on coupling by synchrony within complex neuronal networks, including prefrontal cortex (PFC), hippocampus (HP), and perirhinal cortex (PRH). Yet it remains poorly understood how early life stress (ELS) induces dysfunction within these networks during the course of development. Here we used intermittent maternal separation during the first 2 postnatal weeks to mimic ELS and monitored the recognition memory and functional coupling within prefrontal-hippocampal-perirhinal circuits in juvenile rats...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28100028/perirhinal-cortex-involvement-in-allocentric-spatial-learning-in-the-rat-evidence-from-doubly-marked-tasks
#20
Juan M J Ramos
It has recently been suggested that the different cortices of the medial temporal lobe support a mixture of object and spatial processing functions, challenging the anterior model that emphasized a strict functional differentiation between regions. However, for some structures, the perirhinal cortex (Prh) for example, a number of studies using lesion methods have shown a profound deficit exclusively in tasks involving object learning but not allocentric spatial learning. It may be that the learning paradigms used in previous studies have not been sensitive enough to detect a possible allocentric deficit in Prh-lesioned animals...
May 2017: Hippocampus
keyword
keyword
105833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"