keyword
MENU ▼
Read by QxMD icon Read
search

perirhinal cortex

keyword
https://www.readbyqxmd.com/read/28424398/-brodmann-areas-27-28-36-and-37-the-parahippocampal-and-the-fusiform-gyri
#1
Satoshi Eifuku
First, Brodmann areas 27, 28, 36 and 37, were anatomically defined in the beginning of this review. These areas exist in the parahippocampal or fusiform gyrus of the ventral temporal lobe in humans. Subsequently, the current understanding of their functions was summarized on the basis of recent findings mainly through human functional neuroimaging studies and animal studies. Rodent studies have shown the existence of neuronal activities for representing space, such as those involving head-direction cells or grid cells, in areas 27 (the parasubicular cortex) and 28 (the ventral entorhinal cortex)...
April 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28424397/-spatial-cognition-and-episodic-memory-formation-in-the-limbic-cortex
#2
Yasushi Kobayashi
The limbic lobe defined by Broca is a cortical region with highly diverse structure and functions, and comprises the paleo-, archi-, and neocortices as well as their transitional zones. In the limbic lobe, Brodmann designated areas 27, 28, 34, 35, and 36 adjacent to the hippocampus, and areas 23, 24, 25, 26, 29, 30, 31, 32, and 33 around the corpus callosum. In the current literature, areas 27 and 28 correspond to the presubiculum and entorhinal cortex, respectively. Area 34 represents the cortico-medial part of the amygdaloid complex...
April 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28419566/perirhinal-accumulation-of-neuronal-alpha-synuclein-in-a-multiple-system-atrophy-patient-with-dementia
#3
Mari Saito, Makoto Hara, Momoko Ebashi, Akihiko Morita, Kyoko Okada, Taku Homma, Masahiko Sugitani, Kentaro Endo, Toshiki Uchihara, Satoshi Kamei
We report the case of a 79-year-old Japanese woman who developed cerebellar ataxia followed by rigidity, dysautonomia and cognitive disorders, and was thus clinically diagnosed as having possible MSA with dementia. Neuropathological findings demonstrated not only olivopontocerebellar and striatonigral degeneration with frequent glial cytoplasmic inclusions (GCIs), but also degenerative changes in the parahippocampal region, accentuated in the anterior portion of perirhinal cortex, where neuronal cytoplasmic inclusions (NCIs) and NFTs were numerous while GCIs were limited...
April 16, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28411272/disconnection-of-the-perirhinal-and-postrhinal-cortices-impairs-recognition-of-objects-in-context-but-not-contextual-fear-conditioning
#4
Victoria R Heimer-McGinn, D L Poeta, K Aghi, M Udawatta, R D Burwell
The perirhinal cortex (PER) is known to process object information, whereas the rodent postrhinal cortex (POR), homolog to the parahippocampal cortex (PHC) in primates, is thought to process spatial information. A number of studies, however, provide evidence that both areas are involved in processing contextual information. In this study, we tested the hypothesis that the rat POR relies on object information received from the PER to form complex representations of context. Using three fear conditioning paradigms (signaled, unsignaled, and renewal) and two context-guided object recognition tasks (with 3-dimensional and 2-dimensional objects), we examined the effects of crossed excitotoxic lesions to the POR and the contralateral PER...
April 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28389337/recognition-memory-induced-gene-expression-in-the-perirhinal-cortex-a-transcriptomic-analysis
#5
Hannah Scott, Mark F Rogers, Helen L Scott, Colin Campbell, Elizabeth C Warburton, James B Uney
We have used transcriptome analysis to identify genes and pathways that are activated during recognition memory formation in the perirhinal cortex. Rats were exposed to objects either repeatedly, so that the objects become familiar, or to novel objects in a bow-tie maze over six consecutive days. On the final day, one hour after the last exposure to the series of objects, RNA from the perirhinal cortex was sequenced to compare the transcriptome of naïve control rats and rats exposed to either novel or familiar stimuli...
April 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28367410/contrasting-roles-for-dna-methyltransferases-and-histone-deacetylases-in-single-item-and-associative-recognition-memory
#6
Hannah Scott, Anna E Smith, Gareth R Barker, James B Uney, E Clea Warburton
Recognition memory enables us to judge whether we have encountered a stimulus before and to recall associated information, including where the stimulus was encountered. The perirhinal cortex (PRh) is required for judgment of stimulus familiarity, while hippocampus (HPC) and medial prefrontal cortex (mPFC) are additionally involved when spatial information associated with a stimulus needs to be remembered. While gene expression is known to be essential for the consolidation of long-term recognition memory, the underlying regulatory mechanisms are not fully understood...
March 2017: Neuroepigenetics
https://www.readbyqxmd.com/read/28347878/memory-guided-drawing-training-increases-granger-causal-influences-from-the-perirhinal-cortex-to-v1-in-the-blind
#7
Laura Cacciamani, Lora T Likova
The perirhinal cortex (PRC) is a medial temporal lobe structure that has been implicated in not only visual memory in the sighted, but also tactile memory in the blind (Cacciamani & Likova, 2016). It has been proposed that, in the blind, the PRC may contribute to modulation of tactile memory responses that emerge in low-level "visual" area V1 as a result of training-induced cortical reorganization (Likova, 2012, 2015). While some studies in the sighted have indicated that the PRC is indeed structurally and functionally connected to the visual cortex (Clavagnier, Falchier, & Kennedy, 2004; Peterson, Cacciamani, Barense, & Scalf, 2012), the PRC's direct modulation of V1 is unknown-particularly in those who lack the visual input that typically stimulates this region...
March 24, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28342259/rodent-age-related-impairments-in-discriminating-perceptually-similar-objects-parallel-those-observed-in-humans
#8
Sarah A Johnson, Sean M Turner, Lindsay A Santacroce, Katelyn N Carty, Leila Shafiq, Jennifer L Bizon, Andrew P Maurer, Sara N Burke
The ability to accurately remember distinct episodes is supported by high-level sensory discrimination. Performance on mnemonic similarity tasks, which test high-level discrimination, declines with advancing age in humans and these deficits have been linked to altered activity in hippocampal CA3 and dentate gyrus. Lesion studies in animal models, however, point to the perirhinal cortex as a brain region critical for sensory discriminations that serve memory. Reconciliation of the contributions of different regions within the cortical-hippocampal circuit requires the development of a discrimination paradigm comparable to the human mnemonic similarity task that can be used in rodents...
March 25, 2017: Hippocampus
https://www.readbyqxmd.com/read/28340966/recognition-memory-is-selectively-impaired-in-adult-rats-exposed-to-binge-like-doses-of-ethanol-during-early-postnatal-life
#9
Nicole M MacIlvane, Joseph M Pochiro, Nicole R Hurwitz, Molly J Goodfellow, Derick H Lindquist
Exposure to alcohol in utero can induce a variety of physical and mental impairments, collectively known as fetal alcohol spectrum disorders (FASD). This study explores the persistent cognitive consequences of ethanol administration in rat pups over postnatal days (PD) 4-9, modeling human third trimester consumption. Between PD65-70, ethanol-exposed (5E) and control rats were evaluated in two variants of recognition memory, the spontaneous novel object recognition (NOR) task, using 20 and 240 min sample-to-test delays, and the associative object-in-context (OIC) task, using a 20 min delay...
December 2016: Alcohol
https://www.readbyqxmd.com/read/28304286/family-history-of-alzheimer-s-disease-is-associated-with-impaired-perceptual-discrimination-of-novel-objects
#10
Emily J Mason, Erin P Hussey, Robert J Molitor, Philip C Ko, Manus J Donahue, Brandon A Ally
Early detection may be the key to developing therapies that will combat Alzheimer's disease (AD). It has been consistently demonstrated that one of the main pathologies of AD, tau, is present in the brain decades before a clinical diagnosis. Tau pathology follows a stereotypical route through the medial temporal lobe beginning in the entorhinal and perirhinal cortices. If early pathology leads to very subtle changes in behavior, it may be possible to detect these changes in subjects years before a clinical diagnosis can currently be made...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28289278/cafeteria-diet-and-probiotic-therapy-cross-talk-among-memory-neuroplasticity-serotonin-receptors-and-gut-microbiota-in-the-rat
#11
J E Beilharz, N O Kaakoush, J Maniam, M J Morris
The western diet is known to have detrimental effects on cognition and the gut microbiota, but few studies have investigated how these may be related. Here, we examined whether a probiotic could prevent diet-induced memory deficits. Rats were pre-exposed to vehicle, low or high doses of VSL#3 for 2 weeks before half were switched from chow to a cafeteria diet (Caf) for 25 days; VSL#3 treatment continued until death. High-dose VSL#3 prevented the diet-induced memory deficits on the hippocampal-dependent place task, but the probiotic caused deficits on the perirhinal-dependent object task, irrespective of diet or dose...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28236751/perirhinal-cortex-tracks-degree-of-recent-as-well-as-cumulative-lifetime-experience-with-object-concepts
#12
Devin Duke, Chris B Martin, Ben Bowles, Ken McRae, Stefan Köhler
Evidence from numerous sources indicates that recognition of the prior occurrence of objects requires computations of perirhinal cortex (PrC) in the medial temporal lobe. Extant research has primarily probed recognition memory based on item exposure in a recent experimental study episode. Outside the laboratory, however, familiarity for objects typically accrues gradually with learning across many different episodic contexts, which can be distributed over a lifetime of experience. It is currently unknown whether PrC also tracks this cumulative lifetime experience with object concepts...
January 31, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28169319/early-life-stress-impairs-recognition-memory-and-perturbs-the-functional-maturation-of-prefrontal-hippocampal-perirhinal-networks
#13
Samuel A J Reincke, Ileana L Hanganu-Opatz
Early life exposure to stressful situations impairs cognitive performance of adults and contributes to the etiology of several psychiatric disorders. Most of affected cognitive abilities rely on coupling by synchrony within complex neuronal networks, including prefrontal cortex (PFC), hippocampus (HP), and perirhinal cortex (PRH). Yet it remains poorly understood how early life stress (ELS) induces dysfunction within these networks during the course of development. Here we used intermittent maternal separation during the first 2 postnatal weeks to mimic ELS and monitored the recognition memory and functional coupling within prefrontal-hippocampal-perirhinal circuits in juvenile rats...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28100028/perirhinal-cortex-involvement-in-allocentric-spatial-learning-in-the-rat-evidence-from-doubly-marked-tasks
#14
Juan M J Ramos
It has recently been suggested that the different cortices of the medial temporal lobe support a mixture of object and spatial processing functions, challenging the anterior model that emphasized a strict functional differentiation between regions. However, for some structures, the perirhinal cortex (Prh) for example, a number of studies using lesion methods have shown a profound deficit exclusively in tasks involving object learning but not allocentric spatial learning. It may be that the learning paradigms used in previous studies have not been sensitive enough to detect a possible allocentric deficit in Prh-lesioned animals...
May 2017: Hippocampus
https://www.readbyqxmd.com/read/28073651/i-know-i-ve-seen-you-before-distinguishing-recent-single-exposure-based-familiarity-from-pre-existing-familiarity
#15
Sarah I Gimbel, James B Brewer, Anat Maril
This study examines how individuals differentiate recent-single-exposure-based familiarity from pre-existing familiarity. If these are two distinct cognitive processes, are they supported by the same neural bases? This study examines how recent-single-exposure-based familiarity and multiple-previous-exposure-based familiarity are supported and represented in the brain using functional MRI. In a novel approach, we first behaviorally show that subjects can divide retrieval of items in pre-existing memory into judgments of recollection and familiarity...
January 7, 2017: Brain Research
https://www.readbyqxmd.com/read/28032674/parahippocampal-and-retrosplenial-connections-of-rat-posterior-parietal-cortex
#16
Grethe M Olsen, Shinya Ohara, Toshio Iijima, Menno P Witter
The posterior parietal cortex has been implicated in spatial functions, including navigation. The hippocampal and parahippocampal region and the retrosplenial cortex are crucially involved in navigational processes and connections between the parahippocampal/retrosplenial domain and the posterior parietal cortex have been described. However, an integrated account of the organization of these connections is lacking. Here, we investigated parahippocampal connections of each posterior parietal subdivision and the neighboring secondary visual cortex using conventional retrograde and anterograde tracers as well as transsynaptic retrograde tracing with a modified rabies virus...
December 29, 2016: Hippocampus
https://www.readbyqxmd.com/read/27987389/structural-differences-in-hippocampal-subfields-among-schizophrenia-patients-major-depressive-disorder-patients-and-healthy-subjects
#17
Miho Ota, Noriko Sato, Shinsuke Hidese, Toshiya Teraishi, Norihide Maikusa, Hiroshi Matsuda, Kotaro Hattori, Hiroshi Kunugi
Many MRI studies have reported a volume reduction of the hippocampus in psychiatric diseases. However, disease-related volume differences in hippocampus subfields remain unclear. Here we compared the volumes of hippocampus subfields in patients with schizophrenia, patients with major depressive disorder (MDD), and healthy subjects as controls. T2-weighted images were acquired in 20 patients with schizophrenia, 36 with MDD, and 35 healthy volunteers by 3-Tesla MRI. Hippocampal subfields were segmented using an automatic algorithm, Automatic Segmentation of Hippocampal Subfields (ASHS)...
January 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27932305/scavenging-of-highly-reactive-gamma-ketoaldehydes-attenuates-cognitive-dysfunction-associated-with-epileptogenesis
#18
Jennifer N Pearson, Eric Warren, Li-Ping Liang, L Jackson Roberts, Manisha Patel
Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available. Isoketals and neuroketals, collectively known as gamma-ketoaldehydes are formed via the non-enzymatic, free radical catalyzed oxidation of arachidonic acid and docosahexaenoic acid, respectively. They are attractive candidates for oxidative protein damage and resultant cognitive dysfunction due to their formation within the plasma membrane and their high proclivity to form cytotoxic adducts on protein lysine residues...
February 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/27815215/medial-prefrontal-perirhinal-cortical-communication-is-necessary-for-flexible-response-selection
#19
Abbi R Hernandez, Jordan E Reasor, Leah M Truckenbrod, Katelyn N Lubke, Sarah A Johnson, Jennifer L Bizon, Andrew P Maurer, Sara N Burke
The ability to use information from the physical world to update behavioral strategies is critical for survival across species. The prefrontal cortex (PFC) supports behavioral flexibility; however, exactly how this brain structure interacts with sensory association cortical areas to facilitate the adaptation of response selection remains unknown. Given the role of the perirhinal cortex (PER) in higher-order perception and associative memory, the current study evaluated whether PFC-PER circuits are critical for the ability to perform biconditional object discriminations when the rule for selecting the rewarded object shifted depending on the animal's spatial location in a 2-arm maze...
January 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27764659/laminar-differences-in-associative-memory-signals-in-monkey-perirhinal-cortex
#20
Rufin Vogels
New research published in Neuron describes assignment of cortical layer to single neurons recorded in awake monkeys. Applying the procedure to perirhinal cortex, Koyano et al. (2016) found marked and unsuspected differences among layers in the coding of associative memory signals.
October 19, 2016: Neuron
keyword
keyword
105833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"