keyword
MENU ▼
Read by QxMD icon Read
search

perirhinal cortex

keyword
https://www.readbyqxmd.com/read/29454154/age-related-functional-changes-in-domain-specific-medial-temporal-lobe-pathways
#1
David Berron, Katja Neumann, Anne Maass, Hartmut Schütze, Klaus Fliessbach, Verena Kiven, Frank Jessen, Magdalena Sauvage, Dharshan Kumaran, Emrah Düzel
There is now converging evidence from studies in animals and humans that the medial temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and scene information. Recent functional magnetic resonance imaging studies in humans suggest that this domain-specific organization may be associated with a functional preference of the anterior-lateral part of the entorhinal cortex (alErC) for objects and the posterior-medial entorhinal cortex (pmErC) for scenes. As MTL subregions are differentially affected by aging and neurodegenerative diseases, the question was raised whether aging may affect the 2 pathways differentially...
January 31, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29449430/a-critical-role-for-the-nucleus-reuniens-in-long-term-but-not-short-term-associative-recognition-memory-formation
#2
G R I Barker, E C Warburton
Recognition memory for single items requires the perirhinal cortex (PRH), while recognition of an item and its associated location, requires a functional interaction between the PRH, hippocampus (HPC) and medial prefrontal cortex (mPFC). While the precise mechanisms through which these interactions are effected are unknown, the nucleus reuniens (NRe) has bidirectional connections with each regions and hence may play a role in recognition memory. Here we investigated, in male rats, whether specific manipulations of NRe function affected performance of recognition memory for single items, object location or object-in-place associations...
February 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29417380/assessing-long-term-neuroinflammatory-responses-to-encephalopathy-using-mri-approaches-in-a-rat-endotoxemia-model
#3
Rheal A Towner, D Saunders, N Smith, W Towler, M Cruz, S Do, J E Maher, K Whitaker, M Lerner, K A Morton
Sepsis-associated encephalopathy (SAE) induces neuroinflammation, which is associated with cognitive impairment (CI). CI is also correlated with aging. We used contrast-enhanced magnetic resonance imaging (MRI), perfusion MRI, and MR spectroscopy to assess long-term alterations in BBB permeability, microvascularity, and metabolism, respectively, in a rat lipopolysaccharide-induced SAE model. Free radical-targeted molecular MRI was used to detect brain radical levels at 24 h and 1 week post-LPS injection. CE-MRI showed increased Gd-DTPA uptake in LPS rat brains at 24 h in cerebral cortex, hippocampus, thalamus, and perirhinal cortex regions...
February 7, 2018: GeroScience
https://www.readbyqxmd.com/read/29393853/integrative-and-distinctive-coding-of-visual-and-conceptual-object-features-in-the-ventral-visual-stream
#4
Chris B Martin, Danielle Douglas, Rachel N Newsome, Louisa Ly Man, Morgan Barense
A significant body of research in cognitive neuroscience is aimed at understanding how object concepts are represented in the human brain. However, it remains unknown whether and where the visual and abstract conceptual features that define an object concept are integrated. We addressed this issue by comparing the neural pattern similarities among object-evoked fMRI responses with behavior-based models that independently captured the visual and conceptual similarities among these stimuli. Our results revealed evidence for distinctive coding of visual features in lateral occipital cortex, and conceptual features in the temporal pole and parahippocampal cortex...
February 2, 2018: ELife
https://www.readbyqxmd.com/read/29373631/physiological-and-anatomical-outputs-of-rat-genital-cortex
#5
Constanze Lenschow, Michael Brecht
Rat somatosensory genital cortex contains a large sexually monomorphic representation of the penis in males and the clitoris in females. Genital cortex microstimulation-evoked movements of legs, trunk and genitals, which showed sex-specific differences related to mating behaviors and included thrusting in males and lordosis-like movements in females. Erections/tumescence of penis or clitoris could not be evoked, however. Anterograde tracer injections into penis/clitoris cortex revealed eleven corticocortical and 10 subcortical projection targets, which were qualitatively similar in both sexes...
January 24, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29341361/parvalbumin-interneuron-mediated-feedforward-inhibition-controls-signal-output-in-the-deep-layers-of-the-perirhinal-entorhinal-cortex
#6
Janske G P Willems, Wytse J Wadman, Natalie L M Cappaert
The perirhinal (PER) and lateral entorhinal (LEC) cortex form an anatomical link between the neocortex and the hippocampus. However, neocortical activity is transmitted through the PER and LEC to the hippocampus with a low probability, suggesting the involvement of the inhibitory network. This study explored the role of interneuron mediated inhibition, activated by electrical stimulation in the agranular insular cortex (AiP), in the deep layers of the PER and LEC. Activated synaptic input by AiP stimulation rarely evoked action potentials in the PER-LEC deep layer excitatory principal neurons, most probably because the evoked synaptic response consisted of a small excitatory and large inhibitory conductance...
January 17, 2018: Hippocampus
https://www.readbyqxmd.com/read/29302902/current-topics-regarding-the-function-of-the-medial-temporal-lobe-memory-system
#7
Robert E Clark
The first clear insight that the medial temporal lobe of the human brain was in fact a system of anatomically connected structures that were organized into a memory system came in 1957 from the observations by Brenda Milner of the noted amnesic patient H.M. Subsequent work in humans, monkeys, and rodents has identified all of the components of the medial temporal lobe (MTL) that formed the memory system. Currently, work is ongoing to identify the specific contributions each structure in the medial temporal lobe makes towards the formation and storage of long-term declarative memory...
January 5, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29283632/award-for-distinguished-scientific-early-career-contributions-to-psychology-sara-n-burke
#8
(no author information available yet)
The APA Awards for Distinguished Scientific Early Career Contributions to Psychology recognize psychologists who have demonstrated excellence early in their careers and have held a doctoral degree for no more than 9 years. One of the 2017 award winners is Sara N. Burke, for her groundbreaking work on the impact of age on the perirhinal cortex and associative memory and perception processes. Burke's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29280734/interactions-between-stimulus-and-response-types-are-more-strongly-represented-in-the-entorhinal-cortex-than-in-its-upstream-regions-in-rats
#9
Eun-Hye Park, Jae-Rong Ahn, Inah Lee
Previously we reported results which suggested that response types are critical in dissociating the lateral entorhinal cortex (LEC) from the medial entorhinal cortex (MEC) in a scene memory task (Yoo and Lee, 2017). Here, we investigated whether the perirhinal cortex (PER) and postrhinal cortex (POR), the upstream regions of the LEC and MEC, respectively, could be dissociated similarly. We conducted four tasks by combining different stimulus and response types. Our results suggest that the PER is important whenever object recognition is required and, together with prior findings, imply that PER-LEC networks are essential in goal-directed interactions with objects...
December 27, 2017: ELife
https://www.readbyqxmd.com/read/29246979/dissociable-contributions-of-thalamic-nuclei-to-recognition-memory-novel-evidence-from-a-case-of-medial-dorsal-thalamic-damage
#10
Rachel N Newsome, Alexandra N Trelle, Celia Fidalgo, Bryan Hong, Victoria M Smith, Alexander Jacob, Jennifer D Ryan, R Shayna Rosenbaum, Rosemary A Cowell, Morgan D Barense
The thalamic nuclei are thought to play a critical role in recognition memory. Specifically, the anterior thalamic nuclei and medial dorsal nuclei may serve as critical output structures in distinct hippocampal and perirhinal cortex systems, respectively. Existing evidence indicates that damage to the anterior thalamic nuclei leads to impairments in hippocampal-dependent tasks. However, evidence for the opposite pattern following medial dorsal nuclei damage has not yet been identified. In the present study, we investigated recognition memory in NC, a patient with relatively selective medial dorsal nuclei damage, using two object recognition tests with similar foils: a yes/no (YN) test that requires the hippocampus, and a forced choice corresponding test (FCC) that is supported by perirhinal cortex...
January 2018: Learning & Memory
https://www.readbyqxmd.com/read/29228757/disrupted-functional-connectivity-between-perirhinal-and-parahippocampal-cortices-with-hippocampal-subfields-in-patients-with-mild-cognitive-impairment-and-alzheimer-s-disease
#11
Yu Sun, Yafei Wang, Jiaming Lu, Rengyuan Liu, Christopher G Schwarz, Hui Zhao, Yue Zhang, Lingyi Xu, Bin Zhu, Bing Zhang, Bing Liu, Suiren Wan, Yun Xu
Most patients with mild cognitive impairment and Alzheimer's disease can initially present memory loss. The medial temporal lobes are the brain regions most associated with declarative memory function. As sub-components of the MTL, the perirhinal cortex, parahippocampal cortex and hippocampus have also been identified as playing important roles in memory. The functional connectivity between hippocampus subfields and perirhnial cortices as well as parahippocampal cortices among normal cognition controls (NC group, n=33), mild cognitive impairment (MCI group, n=31) and Alzheimer's disease (AD group, n=27) was investigated in this study...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29192021/contributions-of-primate-prefrontal-cortex-and-medial-temporal-lobe-to-temporal-order-memory
#12
Yuji Naya, He Chen, Cen Yang, Wendy A Suzuki
Neuropsychological and neurophysiological studies have emphasized the role of the prefrontal cortex (PFC) in maintaining information about the temporal order of events or items for upcoming actions. However, the medial temporal lobe (MTL) has also been considered critical to bind individual events or items to their temporal context in episodic memory. Here we characterize the contributions of these brain areas by comparing single-unit activity in the dorsal and ventral regions of macaque lateral PFC (d-PFC and v-PFC) with activity in MTL areas including the hippocampus (HPC), entorhinal cortex, and perirhinal cortex (PRC) as well as in area TE during the encoding phase of a temporal-order memory task...
November 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29184495/polygalae-radix-extract-prevents-axonal-degeneration-and-memory-deficits-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#13
Tomoharu Kuboyama, Keisuke Hirotsu, Tetsuya Arai, Hiroo Yamasaki, Chihiro Tohda
Memory impairments in Alzheimer's disease (AD) occur due to degenerated axons and disrupted neural networks. Since only limited recovery is possible after the destruction of neural networks, preventing axonal degeneration during the early stages of disease progression is necessary to prevent AD. Polygalae Radix (roots of Polygala tenuifolia; PR) is a traditional herbal medicine used for sedation and amnesia. In this study, we aimed to clarify and analyze the preventive effects of PR against memory deficits in a transgenic AD mouse model, 5XFAD...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29175539/intact-perceptual-ability-but-impaired-familiarity-judgment-after-neonatal-perirhinal-lesions-in-rhesus-macaques
#14
Alison R Weiss, Wendi Guo, Rebecca Richardson, Jocelyne Bachevalier
The perirhinal cortex is known to support high-level perceptual abilities as well as familiarity judgments that may affect recognition memory. We tested whether poor perceptual abilities or a loss of familiarity judgment contributed to the recognition memory impairments reported earlier in monkeys with PRh lesions received in infancy (Neo-PRh) (Weiss and Bachevalier, 2016; Zeamer et al., 2015). Perceptual abilities were assessed using a version of the Visual Paired Comparison task with black&white (B&W) stimuli, and familiarity judgments were assessed using the Constant Negative task requiring repeated familiarization exposures...
October 31, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29108942/how-landmark-suitability-shapes-recognition-memory-signals-for-objects-in-the-medial-temporal-lobes
#15
Chris B Martin, Jacqueline A Sullivan, Jessey Wright, Stefan Köhler
A role of perirhinal cortex (PrC) in recognition memory for objects has been well established. Contributions of parahippocampal cortex (PhC) to this function, while documented, remain less well understood. Here, we used fMRI to examine whether the organization of item-based recognition memory signals across these two structures is shaped by object category, independent of any difference in representing episodic context. Guided by research suggesting that PhC plays a critical role in processing landmarks, we focused on three categories of objects that differ from each other in their landmark suitability as confirmed with behavioral ratings (buildings > trees > aircraft)...
November 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/29073645/integration-of-objects-and-space-in-perception-and-memory
#16
REVIEW
Charles E Connor, James J Knierim
Distinct processing of objects and space has been an organizing principle for studying higher-level vision and medial temporal lobe memory. Here, however, we discuss how object and spatial information are in fact closely integrated in vision and memory. The ventral, object-processing visual pathway carries precise spatial information, transformed from retinotopic coordinates into relative dimensions. At the final stages of the ventral pathway, including the dorsal anterior temporal lobe (TEd), object-sensitive neurons are intermixed with neurons that process large-scale environmental space...
October 26, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29067330/differential-medial-temporal-lobe-morphometric-predictors-of-item-and-relational-encoded-memories-in-healthy-individuals-and-in-individuals-with-mild-cognitive-impairment-and-alzheimer-s-disease
#17
Jesus J Gomar, J Daniel Ragland, Aziz M Uluğ, Amber Sousa, Edward D Huey, Concepcion Conejero-Goldberg, Peter Davies, Terry E Goldberg
INTRODUCTION: Episodic memory processes are supported by different subregions of the medial temporal lobe (MTL). In contrast to a unitary model of memory recognition supported solely by the hippocampus, a current model suggests that item encoding engages perirhinal cortex, whereas relational encoding engages parahippocampal cortex and the hippocampus. However, this model has not been examined in the context of aging, neurodegeneration, and MTL morphometrics. METHODS: Forty-four healthy subjects (HSs) and 18 cognitively impaired subjects (nine mild cognitive impairment [MCI] and nine Alzheimer's disease [AD] patients) were assessed with the relational and item-specific encoding task (RISE) and underwent 3T magnetic resonance imaging...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29030298/linking-muscarinic-receptor-activation-to-ups-mediated-object-memory-destabilization-implications-for-long-term-memory-modification-and-storage
#18
Mikaela L Stiver, Jacob M Cloke, Natalie Nightingale, Julian Rizos, William S Messer, Boyer D Winters
Consolidated memories can become destabilized during reactivation, resulting in a transient state of instability, a process that has been hypothesized to underlie long-term memory updating. Consistent with this notion, relatively remote memories, which are resistant to standard destabilization procedures, are reliably destabilized when novel information (i.e., the opportunity for memory updating) is present during reactivation. We have also shown that cholinergic muscarinic receptor (mAChR) activation can similarly destabilize consolidated object memories...
October 10, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28966591/age-related-changes-in-perirhinal-cortex-sensitivity-to-configuration-and-part-familiarity-and-connectivity-to-visual-cortex
#19
Laura Cacciamani, Erica Wager, Mary A Peterson, Paige E Scalf
The perirhinal cortex (PRC) is a medial temporal lobe (MTL) structure known to be involved in assessing whether an object is familiar (i.e., meaningful) or novel. Recent evidence shows that the PRC is sensitive to the familiarity of both whole object configurations and their parts, and suggests the PRC may modulate part familiarity responses in V2. Here, using functional magnetic resonance imaging (fMRI), we investigated age-related decline in the PRC's sensitivity to part/configuration familiarity and assessed its functional connectivity to visual cortex in young and older adults...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28956946/neonatal-perirhinal-cortex-lesions-impair-monkeys-ability-to-modulate-their-emotional-responses
#20
Nathan S Ahlgrim, Jessica Raper, Emily Johnson, Jocelyne Bachevalier
The medial temporal lobe (MTL) is a collection of brain regions best known for their role in perception, memory, and emotional behavior. Within the MTL, the perirhinal cortex (PRh) plays a critical role in perceptual representation and recognition memory, although its contribution to emotional regulation is still debated. Here, rhesus monkeys with neonatal perirhinal lesions (Neo-PRh) and controls (Neo-C) were tested on the Human Intruder (HI) task at 2 months, 4.5 months, and 5 years of age to assess the role of the PRh in the development of emotional behaviors...
October 2017: Behavioral Neuroscience
keyword
keyword
105833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"