keyword
MENU ▼
Read by QxMD icon Read
search

perirhinal cortex

keyword
https://www.readbyqxmd.com/read/29030298/linking-muscarinic-receptor-activation-to-ups-mediated-object-memory-destabilization-implications-for-long-term-memory-modification-and-storage
#1
Mikaela L Stiver, Jacob M Cloke, Natalie Nightingale, Julian Rizos, William S Messer, Boyer D Winters
Consolidated memories can become destabilized during reactivation, resulting in a transient state of instability, a process that has been hypothesized to underlie long-term memory updating. Consistent with this notion, relatively remote memories, which are resistant to standard destabilization procedures, are reliably destabilized when novel information (i.e., the opportunity for memory updating) is present during reactivation. We have also shown that cholinergic muscarinic receptor (mAChR) activation can similarly destabilize consolidated object memories...
October 10, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28966591/age-related-changes-in-perirhinal-cortex-sensitivity-to-configuration-and-part-familiarity-and-connectivity-to-visual-cortex
#2
Laura Cacciamani, Erica Wager, Mary A Peterson, Paige E Scalf
The perirhinal cortex (PRC) is a medial temporal lobe (MTL) structure known to be involved in assessing whether an object is familiar (i.e., meaningful) or novel. Recent evidence shows that the PRC is sensitive to the familiarity of both whole object configurations and their parts, and suggests the PRC may modulate part familiarity responses in V2. Here, using functional magnetic resonance imaging (fMRI), we investigated age-related decline in the PRC's sensitivity to part/configuration familiarity and assessed its functional connectivity to visual cortex in young and older adults...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28956946/neonatal-perirhinal-cortex-lesions-impair-monkeys-ability-to-modulate-their-emotional-responses
#3
Nathan S Ahlgrim, Jessica Raper, Emily Johnson, Jocelyne Bachevalier
The medial temporal lobe (MTL) is a collection of brain regions best known for their role in perception, memory, and emotional behavior. Within the MTL, the perirhinal cortex (PRh) plays a critical role in perceptual representation and recognition memory, although its contribution to emotional regulation is still debated. Here, rhesus monkeys with neonatal perirhinal lesions (Neo-PRh) and controls (Neo-C) were tested on the Human Intruder (HI) task at 2 months, 4.5 months, and 5 years of age to assess the role of the PRh in the development of emotional behaviors...
October 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28922852/magnesium-sulfate-prevents-neurochemical-and-long-term-behavioral-consequences-of-neonatal-excitotoxic-lesions-comparison-between-male-and-female-mice
#4
Ismaël Daher, Bérénice Le Dieu-Lugon, Nathalie Dourmap, Matthieu Lecuyer, Lauriane Ramet, Cathy Gomila, Jérôme Ausseil, Stéphane Marret, Philippe Leroux, Vincent Roy, Salah El Mestikawy, Stéphanie Daumas, Bruno Gonzalez, Isabelle Leroux-Nicollet, Carine Cleren
Magnesium sulfate (MgSO4) administration to mothers at risk of preterm delivery is proposed as a neuroprotective strategy against neurological alterations such as cerebral palsy in newborns. However, long-term beneficial or adverse effects of MgSO4 and sex-specific sensitivity remain to be investigated. We conducted behavioral and neurochemical studies of MgSO4 effects in males and females, from the perinatal period to adolescence in a mouse model of cerebral neonatal lesion. The lesion was produced in 5-day-old (P5) pups by ibotenate intracortical injection...
October 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28890301/antibody-recognizing-4-sulfated-chondroitin-sulfate-proteoglycans-restores-memory-in-tauopathy-induced-neurodegeneration
#5
Sujeong Yang, Sam Hilton, João Nuno Alves, Lisa M Saksida, Timothy Bussey, Russell T Matthews, Hiroshi Kitagawa, Maria Grazia Spillantini, Jessica C F Kwok, James W Fawcett
Chondroitin sulfate proteoglycans (CSPGs) are the main active component of perineuronal nets (PNNs). Digestion of the glycosaminoglycan chains of CSPGs with chondroitinase ABC or transgenic attenuation of PNNs leads to prolongation of object recognition memory and activation of various forms of plasticity in the adult central nervous system. The inhibitory properties of the CSPGs depend on the pattern of sulfation of their glycosaminoglycans, with chondroitin 4-sulfate (C4S) being the most inhibitory form. In this study, we tested a number of candidates for functional blocking of C4S, leading to selection of an antibody, Cat316, which specifically recognizes C4S and blocks its inhibitory effects on axon growth...
November 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28881444/gabaergic-inhibition-gates-excitatory-ltp-in-perirhinal-cortex
#6
Vibhakar C Kotak, Ana Mirallave, Todd M Mowery, Dan H Sanes
The perirhinal cortex (PRh) is a key region downstream of auditory cortex (ACx) that processes familiarity linked mnemonic signaling. In gerbils, ACx-driven EPSPs recorded in PRh neurons are largely shunted by GABAergic inhibition (Kotak et al. 2015). To determine whether inhibitory shunting prevents the induction of excitatory long-term potentiation (e-LTP), we stimulated ACx-recipient PRh in a brain slice preparation using theta burst stimulation (TBS). Under control conditions, without GABA blockers, the majority of PRh neurons exhibited long-term depression...
September 7, 2017: Hippocampus
https://www.readbyqxmd.com/read/28856235/regional-tau-deposition-and-subregion-atrophy-of-medial-temporal-structures-in-early-alzheimer-s-disease-a-combined-positron-emission-tomography-magnetic-resonance-imaging-study
#7
Daichi Sone, Etsuko Imabayashi, Norihide Maikusa, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Masayo Ogawa, Harumasa Takano, Yuma Yokoi, Masuhiro Sakata, Tadashi Tsukamoto, Koichi Kato, Hiroshi Matsuda
INTRODUCTION: Molecular imaging and selective hippocampal subfield atrophy are a focus of recent Alzheimer's disease (AD) research. Here, we investigated correlations between molecular imaging and hippocampal subfields in early AD. METHODS: We investigated 18 patients with early AD and 18 healthy control subjects using (11)C-Pittsburgh compound-B (PIB) positron emission tomography (PET) and (18)F-THK5351 PET and automatic segmentation of hippocampal subfields with high-resolution T2-weighted magnetic resonance imaging...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28852933/extracellular-cytosolic-aspartate-aminotransferase-promotes-axonal-growth-and-object-recognition-memory
#8
Ryo Kobayashi, Chihiro Tohda
Previous proteome analysis studies from other groups have shown that cAST might be secreted from neurons and that cAST was detected in human cerebrospinal fluid. However, none of these studies focused on its role or significance. We therefore investigated the role of extracellular cAST for neurons. cAST was detected in conditioned medium from cultured cortical neurons, but not in fresh medium. Recombinant cAST treatment of cortical neurons significantly extended axonal length. Continuous intracerebroventricular administration of recombinant cAST in normal mice for 14 days significantly enhanced object recognition ability...
August 29, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28828966/chronic-cerebral-hypoperfusion-induced-by-bilateral-carotid-artery-stenosis-causes-selective-recognition-impairment-in-adult-mice
#9
Arati Patel, Alimohammad Moalem, Hank Cheng, Robin M Babadjouni, Kaleena Patel, Drew M Hodis, Deep Chandegara, Steven Cen, Shuhan He, Qinghai Liu, William J Mack
OBJECTIVES: Chronic cerebral hypoperfusion (CCH) can result in vascular dementia and small vessel white matter ischemic injury. These findings have previously been demonstrated in a murine experimental model of CCH secondary to bilateral common carotid artery stenosis (BCAS). This study sought to elucidate the effects of CCH on recognition memory as assessed by the novel object recognition (NOR) test and histological analysis of the hippocampus and perirhinal cortex. METHODS: Studies were performed on ten-week-old male mice using bilateral 0...
October 2017: Neurological Research
https://www.readbyqxmd.com/read/28821661/attenuated-activity-across-multiple-cell-types-and-reduced-monosynaptic-connectivity-in-the-aged-perirhinal-cortex
#10
Andrew P Maurer, Sara N Burke, Kamran Diba, Carol A Barnes
The perirhinal cortex (PER), which is critical for associative memory and stimulus discrimination, has been described as a wall of inhibition between the neocortex and hippocampus. With advanced age, rats show deficits on PER-dependent behavioral tasks and fewer PER principal neurons are activated by stimuli, but the role of PER interneurons in these altered circuit properties in old age has not been characterized. In the present study, PER neurons were recorded while rats traversed a circular track bidirectionally in which the track was either empty or contained eight novel objects evenly spaced around the track...
September 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28818944/conversion-of-object-identity-to-object-general-semantic-value-in-the-primate-temporal-cortex
#11
Keita Tamura, Masaki Takeda, Rieko Setsuie, Tadashi Tsubota, Toshiyuki Hirabayashi, Kentaro Miyamoto, Yasushi Miyashita
At the final stage of the ventral visual stream, perirhinal neurons encode the identity of memorized objects through learning. However, it remains elusive whether and how object percepts alone, or concomitantly a nonphysical attribute of the objects ("learned"), are decoded from perirhinal activities. By combining monkey psychophysics with optogenetic and electrical stimulations, we found a focal spot of memory neurons where both stimulations led monkeys to preferentially judge presented objects as "already seen...
August 18, 2017: Science
https://www.readbyqxmd.com/read/28807794/flavor-and-object-recognition-memory-impairment-induced-by-excitotoxic-lesions-of-the-perirhinal-cortex
#12
E Morillas, B Gómez-Chacón, M Gallo
Recognition memory is based on the ability to assess the familiarity of a previously encountered stimulus. It can be approached using tests for different sensorial modalities. Excitotoxic lesions of the perirhinal cortex (Prh) were performed in order to assess the relevance of its integrity for object and flavor recognition memory. Object recognition memory was impaired with a 24h retention interval. Flavor neophobia attenuation was prevented on a second encounter with the tastant. These results support a role of the perirhinal cortex in mediating the transition from novel to familiar, both in object and flavor recognition memory...
August 12, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28798130/two-areas-for-familiar-face-recognition-in-the-primate-brain
#13
Sofia M Landi, Winrich A Freiwald
Familiarity alters face recognition: Familiar faces are recognized more accurately than unfamiliar ones and under difficult viewing conditions when unfamiliar face recognition fails. The neural basis for this fundamental difference remains unknown. Using whole-brain functional magnetic resonance imaging, we found that personally familiar faces engage the macaque face-processing network more than unfamiliar faces. Familiar faces also recruited two hitherto unknown face areas at anatomically conserved locations within the perirhinal cortex and the temporal pole...
August 11, 2017: Science
https://www.readbyqxmd.com/read/28790897/regional-specific-evidence-for-memory-load-dependent-activity-in-the-dorsal-subiculum-and-the-lateral-entorhinal-cortex
#14
Shih-Pi Ku, Nozomu H Nakamura, Nicolas Maingret, Liv Mahnke, Motoharu Yoshida, Magdalena M Sauvage
The subiculum and the lateral entorhinal cortex (LEC) are the main output areas of the hippocampus which contribute to spatial and non-spatial memory. The proximal part of the subiculum (bordering CA1) receives heavy projections from the perirhinal cortex and the distal part of CA1 (bordering the subiculum), both known for their ties to object recognition memory. However, the extent to which the proximal subiculum contributes to non-spatial memory is still unclear. Comparatively, the involvement of the LEC in non-spatial information processing is quite well known...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28765070/prefrontal-connections-of-the-perirhinal-and-postrhinal-cortices-in-the-rat
#15
Eunkyu Hwang, Bailey S Willis, Rebecca D Burwell
Knowing how prefrontal regions interact with medial temporal lobe structures is important for understanding memory and cognition. Using anterograde and retrograde tract tracing methods in the rat, we report a detailed study of the perirhinal (PER) and postrhinal (POR) connections with the lateral, ventrolateral, and medial orbitofrontal cortices (ORBl, ORBvl, ORBm), infralimbic and prelimbic cortices (IL, PL), ventral and dorsal anterior cingulate cortices (ACAv, ACAd), and secondary motor cortex (MOs). Our analyses included the topography and laminar patterns of these connections...
July 29, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28761928/familiarity-deficits-in-cognitively-normal-aging-individuals-with-apoe-%C3%AE%C2%B54-a-follow-up-investigation-of-medial-temporal-lobe-structural-correlates
#16
Dorothee Schoemaker, Judes Poirier, D Louis Collins, Serge Gauthier, Jens C Pruessner
INTRODUCTION: The apolipoprotein E ε4 (APOE ε4) allele is a well-documented risk factor for Alzheimer's disease (AD). Accordingly, aging individuals carrying one or more ε4 alleles are at considerably greater risk of developing AD over time. In an effort to characterize early cognitive manifestations of AD, we previously outlined selective deficits in familiarity-based recognition in otherwise asymptomatic carriers of the APOE ε4 allele (Schoemaker et al., 2016). In this follow-up report, we aimed to explore the neural correlates of this selective cognitive impairment...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28752156/accounting-for-the-confound-of-meninges-in-segmenting-entorhinal-and-perirhinal-cortices-in-t1-weighted-mri
#17
Long Xie, Laura E M Wisse, Sandhitsu R Das, Hongzhi Wang, David A Wolk, Jose V Manjón, Paul A Yushkevich
Quantification of medial temporal lobe (MTL) cortices, including entorhinal cortex (ERC) and perirhinal cortex (PRC), from in vivo MRI is desirable for studying the human memory system as well as in early diagnosis and monitoring of Alzheimer's disease. However, ERC and PRC are commonly over-segmented in T1-weighted (T1w) MRI because of the adjacent meninges that have similar intensity to gray matter in T1 contrast. This introduces errors in the quantification and could potentially confound imaging studies of ERC/PRC...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28701931/architecture-of-the-entorhinal-cortex-a-review-of-entorhinal-anatomy-in-rodents-with-some-comparative-notes
#18
REVIEW
Menno P Witter, Thanh P Doan, Bente Jacobsen, Eirik S Nilssen, Shinya Ohara
The entorhinal cortex (EC) is the major input and output structure of the hippocampal formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes including two or many more subdivisions have been proposed, but here we will argue that subdividing EC into two components, the lateral EC (LEC) and medial EC (MEC) might suffice to describe the functional architecture of EC. This subdivision then leads to an anatomical interpretation of the different phenotypes of LEC and MEC. First, we will briefly summarize the cytoarchitectonic differences and differences in hippocampal projection patterns on which the subdivision between LEC and MEC traditionally is based and provide a short comparative perspective...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28685167/medial-temporal-pathways-for-contextual-learning-network-c-fos-mapping-in-rats-with-or-without-perirhinal-cortex-lesions
#19
Lisa Kinnavane, Eman Amin, Cristian M Olarte-Sánchez, John P Aggleton
BACKGROUND: In the rat brain, context information is thought to engage network interactions between the postrhinal cortex, medial entorhinal cortex, and the hippocampus. In contrast, object information is thought to be more reliant on perirhinal cortex and lateral entorhinal cortex interactions with the hippocampus. METHOD: The 'context network' was explored by mapping expression of the immediate-early gene, c-fos, after exposure to a new spatial environment. RESULTS: Structural equation modelling of Fos counts produced networks of good fit that closely matched prior predictions based on anatomically-grounded functional models...
March 14, 2017: Brain and neuroscience advances
https://www.readbyqxmd.com/read/28652965/a-protocol-for-manual-segmentation-of-medial-temporal-lobe-subregions-in-7%C3%A2-tesla-mri
#20
D Berron, P Vieweg, A Hochkeppler, J B Pluta, S-L Ding, A Maass, A Luther, L Xie, S R Das, D A Wolk, T Wolbers, P A Yushkevich, E Düzel, L E M Wisse
Recent advances in MRI and increasing knowledge on the characterization and anatomical variability of medial temporal lobe (MTL) anatomy have paved the way for more specific subdivisions of the MTL in humans. In addition, recent studies suggest that early changes in many neurodegenerative and neuropsychiatric diseases are better detected in smaller subregions of the MTL rather than with whole structure analyses. Here, we developed a new protocol using 7 Tesla (T) MRI incorporating novel anatomical findings for the manual segmentation of entorhinal cortex (ErC), perirhinal cortex (PrC; divided into area 35 and 36), parahippocampal cortex (PhC), and hippocampus; which includes the subfields subiculum (Sub), CA1, CA2, as well as CA3 and dentate gyrus (DG) which are separated by the endfolial pathway covering most of the long axis of the hippocampus...
2017: NeuroImage: Clinical
keyword
keyword
105833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"