keyword
MENU ▼
Read by QxMD icon Read
search

perirhinal cortex

keyword
https://www.readbyqxmd.com/read/29649304/sedentary-behavior-associated-with-reduced-medial-temporal-lobe-thickness-in-middle-aged-and-older-adults
#1
Prabha Siddarth, Alison C Burggren, Harris A Eyre, Gary W Small, David A Merrill
Atrophy of the medial temporal lobe (MTL) occurs with aging, resulting in impaired episodic memory. Aerobic fitness is positively correlated with total hippocampal volume, a heavily studied memory-critical region within the MTL. However, research on associations between sedentary behavior and MTL subregion integrity is limited. Here we explore associations between thickness of the MTL and its subregions (namely CA1, CA23DG, fusiform gyrus, subiculum, parahippocampal, perirhinal and entorhinal cortex,), physical activity, and sedentary behavior...
2018: PloS One
https://www.readbyqxmd.com/read/29604176/deficits-in-prospective-memory-following-damage-to-the-medial-subdivision-of-the-mediodorsal-thalamic-nucleus
#2
Giorgia Cona, Gianvito Laera, Nicola Edelstyn, Patrizia S Bisiacchi
Identifying the neurocognitive mechanisms that lead individuals remembering to execute an intention at the right moment (prospective memory, PM) and how such mechanisms are influenced by the features of that intention is a fundamental theoretical challenge. In particular, the functional contribution of subcortical regions to PM is still unknown. This study was aimed at investigating the role of the medial subdivision of the mediodorsal thalamic nucleus (mMDT) in PM, with particular focus on the processes that are mediated by the projections from/to this structure...
March 31, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29593501/chronic-stress-reduces-nectin-1-mrna-levels-and-disrupts-dendritic-spine-plasticity-in-the-adult-mouse-perirhinal-cortex
#3
Qian Gong, Yun-Ai Su, Chen Wu, Tian-Mei Si, Jan M Deussing, Mathias V Schmidt, Xiao-Dong Wang
In adulthood, chronic exposure to stressful experiences disrupts synaptic plasticity and cognitive function. Previous studies have shown that perirhinal cortex-dependent object recognition memory is impaired by chronic stress. However, the stress effects on molecular expression and structural plasticity in the perirhinal cortex remain unclear. In this study, we applied the chronic social defeat stress (CSDS) paradigm and measured the mRNA levels of nectin-1, nectin-3 and neurexin-1, three synaptic cell adhesion molecules (CAMs) implicated in the adverse stress effects, in the perirhinal cortex of wild-type (WT) and conditional forebrain corticotropin-releasing hormone receptor 1 conditional knockout (CRHR1-CKO) mice...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29589322/current-topics-regarding-the-function-of-the-medial-temporal-lobe-memory-system
#4
Robert E Clark
The first clear insight that the medial temporal lobe of the human brain was in fact a system of anatomically connected structures that were organized into a memory system came in 1957 from the observations by Brenda Milner of the noted amnesic patient H.M. Subsequent work in humans, monkeys, and rodents has identified all of the components of the medial temporal lobe (MTL) that formed the memory system. Currently, work is ongoing to identify the specific contributions each structure in the medial temporal lobe makes towards the formation and storage of long-term declarative memory...
2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29555181/shared-functions-of-perirhinal-and-parahippocampal-cortices-implications-for-cognitive-aging
#5
REVIEW
Sara N Burke, Leslie S Gaynor, Carol A Barnes, Russell M Bauer, Jennifer L Bizon, Erik D Roberson, Lee Ryan
A predominant view of perirhinal cortex (PRC) and postrhinal/parahippocampal cortex (POR/PHC) function contends that these structures are tuned to represent objects and spatial information, respectively. However, known anatomical connectivity, together with recent electrophysiological, neuroimaging, and lesion data, indicate that both brain areas participate in spatial and nonspatial processing. Instead of content-based organization, the PRC and PHC/POR may participate in two computationally distinct cortical-hippocampal networks: one network that is tuned to process coarse information quickly, forming gist-like representations of scenes/environments, and a second network tuned to process information about the specific sensory details that are necessary for discrimination across sensory modalities...
March 16, 2018: Trends in Neurosciences
https://www.readbyqxmd.com/read/29540322/persistent-nature-of-alterations-in-cognition-and-neuronal-circuit-excitability-after-exposure-to-simulated-cosmic-radiation-in-mice
#6
Vipan K Parihar, Mattia Maroso, Amber Syage, Barrett D Allen, Maria C Angulo, Ivan Soltesz, Charles L Limoli
Of the many perils associated with deep space travel to Mars, neurocognitive complications associated with cosmic radiation exposure are of particular concern. Despite these realizations, whether and how realistic doses of cosmic radiation cause cognitive deficits and neuronal circuitry alterations several months after exposure remains unclear. In addition, even less is known about the temporal progression of cosmic radiation-induced changes transpiring over the duration of a time period commensurate with a flight to Mars...
March 11, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29524468/characterizing-age-related-decline-of-recognition-memory-and-brain-activation-profile-in-mice
#7
Hassina Belblidia, Marianne Leger, Abdelouadoud Abdelmalek, Anne Quiedeville, Floriane Calocer, Michel Boulouard, Christelle Jozet-Alves, Thomas Freret, Pascale Schumann-Bard
Episodic memory decline is one of the earlier deficits occurring during normal aging in humans. The question of spatial versus non-spatial sensitivity to age-related memory decline is of importance for a full understanding of these changes. Here, we characterized the effect of normal aging on both non-spatial (object) and spatial (object location) memory performances as well as on associated neuronal activation in mice. Novel-object (NOR) and object-location (OLR) recognition tests, respectively assessing the identity and spatial features of object memory, were examined at different ages...
March 7, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29516634/diminution-of-context-association-memory-structure-in-subjects-with-subjective-cognitive-decline
#8
Ling-Yun Fan, Ya-Mei Lai, Ta-Fu Chen, Yung-Chin Hsu, Pin-Yu Chen, Kuo-Zhou Huang, Ting-Wen Cheng, Wen-Yi Isaac Tseng, Mau-Sun Hua, Ya-Fang Chen, Ming-Jang Chiu
Alzheimer's disease (AD) progresses insidiously from the preclinical stage to dementia. While people with subjective cognitive decline (SCD) have normal cognitive performance, some may be in the preclinical stage of AD. Neurofibrillary tangles appear first in the transentorhinal cortex, followed by the entorhinal cortex in the clinically silent stage of AD. We expected the earliest changes in subjects with SCD to occur in medial temporal subfields other than the hippocampal proper. These selective structural changes would affect specific memory subcomponents...
March 8, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29493506/in-sight-in-mind
#9
Mariam Aly
A region of the brain called the perirhinal cortex represents both what things look like and what they mean.
March 1, 2018: ELife
https://www.readbyqxmd.com/read/29484523/muscarinic-receptor-dependent-long-term-depression-in-the-perirhinal-cortex-and-recognition-memory-are-impaired-in-the-rtg4510-mouse-model-of-tauopathy
#10
Sarah E Scullion, Gareth R I Barker, E Clea Warburton, Andrew D Randall, Jonathan T Brown
Neurodegenerative diseases affecting cognitive dysfunction, such as Alzheimer's disease and fronto-temporal dementia, are often associated impairments in the visual recognition memory system. Recent evidence suggests that synaptic plasticity, in particular long term depression (LTD), in the perirhinal cortex (PRh) is a critical cellular mechanism underlying recognition memory. In this study, we have examined novel object recognition and PRh LTD in rTg4510 mice, which transgenically overexpress tauP301L . We found that 8-9 month old rTg4510 mice had significant deficits in long- but not short-term novel object recognition memory...
February 26, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29464195/danger-changes-the-way-the-mammalian-brain-stores-information-about-innocuous-events-a-study-of-sensory-preconditioning-in-rats
#11
Nathan M Holmes, Mukesh Raipuria, Omar A Qureshi, Simon Killcross, Fred Westbrook
The amygdala is a critical substrate for learning about cues that signal danger. Less is known about its role in processing innocuous or background information. The present study addressed this question using a sensory preconditioning protocol in male rats. In each experiment, rats were exposed to pairings of two innocuous stimuli in stage 1, S2 and S1, and then to pairings of S1 and shock in stage 2. As a consequence of this training, control rats displayed defensive reactions (freezing) when tested with both S2 and S1...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29454154/age-related-functional-changes-in-domain-specific-medial-temporal-lobe-pathways
#12
David Berron, Katja Neumann, Anne Maass, Hartmut Schütze, Klaus Fliessbach, Verena Kiven, Frank Jessen, Magdalena Sauvage, Dharshan Kumaran, Emrah Düzel
There is now converging evidence from studies in animals and humans that the medial temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and scene information. Recent functional magnetic resonance imaging studies in humans suggest that this domain-specific organization may be associated with a functional preference of the anterior-lateral part of the entorhinal cortex (alErC) for objects and the posterior-medial entorhinal cortex (pmErC) for scenes. As MTL subregions are differentially affected by aging and neurodegenerative diseases, the question was raised whether aging may affect the 2 pathways differentially...
January 31, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29449430/a-critical-role-for-the-nucleus-reuniens-in-long-term-but-not-short-term-associative-recognition-memory-formation
#13
G R I Barker, E C Warburton
Recognition memory for single items requires the perirhinal cortex (PRH), while recognition of an item and its associated location, requires a functional interaction between the PRH, hippocampus (HPC) and medial prefrontal cortex (mPFC). While the precise mechanisms through which these interactions are effected are unknown, the nucleus reuniens (NRe) has bidirectional connections with each regions and hence may play a role in recognition memory. Here we investigated, in male rats, whether specific manipulations of NRe function affected performance of recognition memory for single items, object location or object-in-place associations...
February 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29417380/assessing-long-term-neuroinflammatory-responses-to-encephalopathy-using-mri-approaches-in-a-rat-endotoxemia-model
#14
Rheal A Towner, D Saunders, N Smith, W Towler, M Cruz, S Do, J E Maher, K Whitaker, M Lerner, K A Morton
Sepsis-associated encephalopathy (SAE) induces neuroinflammation, which is associated with cognitive impairment (CI). CI is also correlated with aging. We used contrast-enhanced magnetic resonance imaging (MRI), perfusion MRI, and MR spectroscopy to assess long-term alterations in BBB permeability, microvascularity, and metabolism, respectively, in a rat lipopolysaccharide-induced SAE model. Free radical-targeted molecular MRI was used to detect brain radical levels at 24 h and 1 week post-LPS injection. CE-MRI showed increased Gd-DTPA uptake in LPS rat brains at 24 h in cerebral cortex, hippocampus, thalamus, and perirhinal cortex regions...
February 7, 2018: GeroScience
https://www.readbyqxmd.com/read/29393853/integrative-and-distinctive-coding-of-visual-and-conceptual-object-features-in-the-ventral-visual-stream
#15
Chris B Martin, Danielle Douglas, Rachel N Newsome, Louisa Ly Man, Morgan Barense
A significant body of research in cognitive neuroscience is aimed at understanding how object concepts are represented in the human brain. However, it remains unknown whether and where the visual and abstract conceptual features that define an object concept are integrated. We addressed this issue by comparing the neural pattern similarities among object-evoked fMRI responses with behavior-based models that independently captured the visual and conceptual similarities among these stimuli. Our results revealed evidence for distinctive coding of visual features in lateral occipital cortex, and conceptual features in the temporal pole and parahippocampal cortex...
February 2, 2018: ELife
https://www.readbyqxmd.com/read/29373631/physiological-and-anatomical-outputs-of-rat-genital-cortex
#16
Constanze Lenschow, Michael Brecht
Rat somatosensory genital cortex contains a large sexually monomorphic representation of the penis in males and the clitoris in females. Genital cortex microstimulation-evoked movements of legs, trunk and genitals, which showed sex-specific differences related to mating behaviors and included thrusting in males and lordosis-like movements in females. Erections/tumescence of penis or clitoris could not be evoked, however. Anterograde tracer injections into penis/clitoris cortex revealed eleven corticocortical and 10 subcortical projection targets, which were qualitatively similar in both sexes...
April 1, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29341361/parvalbumin-interneuron-mediated-feedforward-inhibition-controls-signal-output-in-the-deep-layers-of-the-perirhinal-entorhinal-cortex
#17
Janske G P Willems, Wytse J Wadman, Natalie L M Cappaert
The perirhinal (PER) and lateral entorhinal (LEC) cortex form an anatomical link between the neocortex and the hippocampus. However, neocortical activity is transmitted through the PER and LEC to the hippocampus with a low probability, suggesting the involvement of the inhibitory network. This study explored the role of interneuron mediated inhibition, activated by electrical stimulation in the agranular insular cortex (AiP), in the deep layers of the PER and LEC. Activated synaptic input by AiP stimulation rarely evoked action potentials in the PER-LEC deep layer excitatory principal neurons, most probably because the evoked synaptic response consisted of a small excitatory and large inhibitory conductance...
January 17, 2018: Hippocampus
https://www.readbyqxmd.com/read/29302902/current-topics-regarding-the-function-of-the-medial-temporal-lobe-memory-system
#18
Robert E Clark
The first clear insight that the medial temporal lobe of the human brain was in fact a system of anatomically connected structures that were organized into a memory system came in 1957 from the observations by Brenda Milner of the noted amnesic patient H.M. Subsequent work in humans, monkeys, and rodents has identified all of the components of the medial temporal lobe (MTL) that formed the memory system. Currently, work is ongoing to identify the specific contributions each structure in the medial temporal lobe makes towards the formation and storage of long-term declarative memory...
January 5, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29283632/award-for-distinguished-scientific-early-career-contributions-to-psychology-sara-n-burke
#19
(no author information available yet)
The APA Awards for Distinguished Scientific Early Career Contributions to Psychology recognize psychologists who have demonstrated excellence early in their careers and have held a doctoral degree for no more than 9 years. One of the 2017 award winners is Sara N. Burke, for her groundbreaking work on the impact of age on the perirhinal cortex and associative memory and perception processes. Burke's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29280734/interactions-between-stimulus-and-response-types-are-more-strongly-represented-in-the-entorhinal-cortex-than-in-its-upstream-regions-in-rats
#20
Eun-Hye Park, Jae-Rong Ahn, Inah Lee
Previously we reported results which suggested that response types are critical in dissociating the lateral entorhinal cortex (LEC) from the medial entorhinal cortex (MEC) in a scene memory task (Yoo and Lee, 2017). Here, we investigated whether the perirhinal cortex (PER) and postrhinal cortex (POR), the upstream regions of the LEC and MEC, respectively, could be dissociated similarly. We conducted four tasks by combining different stimulus and response types. Our results suggest that the PER is important whenever object recognition is required and, together with prior findings, imply that PER-LEC networks are essential in goal-directed interactions with objects...
December 27, 2017: ELife
keyword
keyword
105833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"