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https://www.readbyqxmd.com/read/28319269/withdrawn-trimetazidine-for-stable-angina
#1
REVIEW
Agustín Ciapponi, Rudolf Pizarro, Jeff Harrison
BACKGROUND: Patients with stable angina not controlled by monotherapy with nitrates, beta blockers, or calcium channel blockers are often treated with combinations of these drugs. There may be adverse effects from, or contraindications to, the use of combinations. In low risk groups, medical treatment appears to be as good an option as percutaneous transluminal coronary angioplasty in terms of averting myocardial infarction, death, or subsequent revascularization. Revascularization procedures are too costly or inaccessible for many patients in developing countries therefore effective and safe medical treatment is needed...
March 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28294866/-treatment-of-patients-with-stable-ischemic-heart-disease-in-real-clinical-practice-in-russia-the-choice-2-program
#2
G Glezer M, On Behalf Of The Choice-Study Participants On Behalf Of The Choice-Study Participants
OBJECTIVE: in the framework of an open post-marketing observational national program CHOICE-2 to assess correspondence between recommendations for management of patients with stable angina and actual clinical practice, as well as to assess effect of treatment with cytoprotector trimetazidine on clinical course of the disease. MATERIAL AND METHODS: Participating physicians (n=185 from 46 regions of Russian Federation) recruited 896 patients with ischemic heart disease (IHD)...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28282906/gsk3%C3%AE-and-vdac-involvement-in-er-stress-and-apoptosis-modulation-during-orthotopic-liver-transplantation
#3
Mohamed Amine Zaouali, Arnau Panisello, Alexandre Lopez, Carlos Castro, Emma Folch, Teresa Carbonell, Anabela Rolo, Carlos Marques Palmeira, Agustin Garcia-Gil, René Adam, Joan Roselló-Catafau
We investigated the involvement of glycogen synthase kinase-3β (GSK3β) and the voltage-dependent anion channel (VDAC) in livers subjected to cold ischemia-reperfusion injury (I/R) associated with orthotopic liver transplantation (OLT). Rat livers were preserved in University of Wisconsin (UW) and Institute Georges Lopez (IGL-1) solution, the latter enriched or not with trimetazidine, and then subjected to OLT. Transaminase (ALT) and HMGB1 protein levels, glutamate dehydrogenase (GLDH), and oxidative stress (MDA) were measured...
March 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28261829/trimetazidine-has-protective-effects-on-spermatogenesis-in-a-streptozotocin-induced-diabetic-rat-model
#4
M F Ozcan, E R Hekimoglu, K Ener, M Namuslu, R Altintas, H T Celik, Z Akbulut, S Altinova
The aim of this study was to investigate the protective effects of trimetazidine (TMZ), as an antioxidant agent, on streptozotocin (STZ)-induced diabetic rats. A total of 50 male Sprague Dawley rats were randomly classified into five groups as follows: Group 1 (control), Group 2 (STZ-induced diabetic rats), Group 3 (STZ-induced diabetic rats treated orally with 1 cc/day isotonic saline), Group 4 (diabetic rats treated orally with 10 mg/kg/day TMZ) and Group 5 (diabetic rats treated orally with 20 mg/kg/day TMZ)...
March 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28260320/-impact-of-trimetazidine-pre-treatment-on-5-hydroxytryptamine-and-serotonin-transporter-in-rats-with-experimental-myocardial-infarction-and-depression
#5
M Y Liu, L J Zhang
Objective: To explore the effect of trimetazidine pre-treatments on serum 5-hydroxytryptamine (5-HT) and serotonin transporter (SERT), platelet 5-HT and SERT in the Sprague Dawley rats with myocardial infarction(MI), depression, and myocardial infarction co-exist with depression (MI+ depression) and in sham operated rats. Methods: Eighty rats were divided into treatment group and placebo (saline) group by the random number table method (n=40 each group). After 4 weeks' treatment with trimetazidine, or saline, these rats were assigned to respective sham subgroup, depression subgroup, MI subgroup, MI + depression subgroup (n=10 each subgroup)...
February 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28256321/trimetazidine-in-conditions-other-than-coronary-disease-old-drug-new-tricks
#6
REVIEW
Hai Zou, Xing-Xing Zhu, Ya-Hui Ding, Qin-Yang Jin, Lin-Yan Qian, Dong-Sheng Huang, Xue-Jiang Cen
Trimetazidine (TMZ) has traditionally been used as an anti-ischemic drug for coronary artery disease by selectively inhibiting the mitochondrial long-chain 3-ketoacyl-CoA thiolase. Recently, new applications for this therapy have been investigated. This article reviews alternative uses for TMZ in non-coronary artery diseases, such as non-ischemic cardiomyopathy, sepsis, myocardial dysfunction induced by anti-cancer drugs, diabetic cardiomyopathy and contrast-induced nephropathy.
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28248861/clinical-effect-of-trimetazidine-on-prevention-of-contrast-induced-nephropathy-in-patients-with-renal-insufficiency-an-updated-systematic-review-and-meta-analysis
#7
REVIEW
Ziliang Ye, Haili Lu, Qiang Su, Wenqin Guo, Weiran Dai, Hongqing Li, Huafeng Yang, Lang Li
BACKGROUND: With the continuous development of cardiac interventional medicine, the incidence of contrast-induced nephropathy (CIN) is increasing every year, which is a serious threat to people's physical and mental health. Trimetazidine (TMZ) is a type of anti-ischemic drug developed in recent years, which can significantly reduce the incidence of CIN. At present, a systematic review and meta-analysis was conducted to evaluate the clinical effect of TMZ on prevention of CIN in patients with renal insufficiency...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28238270/effects-of-trimetazidine-on-interleukin-2-and-interleukin-8-concentrations-in-patients-with-coronary-artery-disease
#8
Aleksander Danikiewicz, Janusz Szkodziński, Bartosz Hudzik, Ilona Korzonek-Szlacheta, Mariusz Gasior, Barbara Zubelewicz-Szkodzińska
Trimetazidine (TMZ) exhibits metabolic and cardioprotective effects. The aim of this study was to access the effects of TMZ on IL-2 and IL-8 serum concentrations in 156 patients with stable coronary artery disease. They underwent treadmill exercise test (TET) before and after 3-month TMZ treatment. IL-2 and IL-8 concentrations were determined before and after each TET. Before treatment, TET didn't influence IL-2 concentrations, whereas IL-8 concentrations increased. TMZ treatment led to a decrease in IL-2 concentrations before TET, as well as it made the observed difference in IL-8 concentrations become statistically insignificant following the second TET...
February 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28220388/real-world-evidence-for-the-antianginal-efficacy-of-trimetazidine-from%C3%A2-the%C3%A2-russian-observational-choice-2-study
#9
Maria Glezer
INTRODUCTION: The guidelines recommend a beta-blocker or calcium channel blocker as the first-line medication for angina, supplemented by other agents for additional symptoms. One such agent is trimetazidine (TMZ), which has been shown to reduce the frequency of anginal episodes and improve exercise performance without affecting haemodynamic parameters. However, extensive real-world evidence for its efficacy in combination with first-line therapies has been lacking. METHODS: The aim of this large-scale, Russian, multicentre, 6-month, open-label, prospective observational study was to assess the effect of adding TMZ modified release 35 mg bid to background antianginal therapy in the real-world clinical setting...
February 20, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28188510/medication-use-and-risk-of-falls-among-nursing-home-residents-a-retrospective-cohort-study
#10
Andrea Bor, Mária Matuz, Márta Csatordai, Gábor Szalai, András Bálint, Ria Benkő, Gyöngyvér Soós, Péter Doró
Background Geriatric falls are leading causes of hospital trauma admissions and injury-related deaths. Medication use is a crucial element among extrinsic risk factors for falls. To reduce fall risk and the prevalence of adverse drug reactions, potentially inappropriate medication (PIM) lists are widely used. Objective Our aim was to investigate the possible predictors of geriatric falls annualized over a 5-year-long period, as well as to evaluate the medication use of nursing home residents. Setting Nursing home residents were recruited from the same institution between 2010 and 2015 in Szeged, Hungary...
February 10, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28177664/trimetazidine-potentiates-the-antiepileptic-activity-and-ameliorates-the-metabolic-changes-associated-with-pentylentetrazole-kindling-in-rats-treated-with-valproic-acid
#11
Amina Ahmed Sedky, Osama Mahmod Elserafy, Olfat A Hassan, Hala Salah Abdel Kawy, Amany Hasanin, Mona Hussein Raafat
Oxidative stress is implicated in epileptogenesis as well as in the metabolic changes associated with increased risk of atherosclerotic vascular disease in epilepsy. The present work investigated the impact of the antioxidants trimetazidine (TMZ) on the antiepileptic activity of valproic acid (VAP) and on the metabolic and histological changes in hippocampal, aortic and hepatic tissues associated with epilepsy and/or VPA. Rats were divided into: Non-Pentylentetrazole (PTZ) group; subdivided into: control and VPA treated groups, PTZ-treated group subdivided into: PTZ, PTZ/VPA, PTZ/TMZ, PTZ/VPA+TMZ groups...
January 29, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28151965/prevention-of-contrast-induced-acute-kidney-injury-in-patients-undergoing-cardiovascular-procedures-a-systematic-review-and-network-meta-analysis
#12
Eliano P Navarese, Paul A Gurbel, Felicita Andreotti, Michalina Marta Kołodziejczak, Suetonia C Palmer, Sofia Dias, Antonino Buffon, Jacek Kubica, Mariusz Kowalewski, Tomasz Jadczyk, Michał Laskiewicz, Marek Jędrzejek, Maximillian Brockmeyer, Flavio Airoldi, Marinella Ruospo, Stefano De Servi, Wojciech Wojakowski, Christopher O' Connor, Giovanni F M Strippoli
BACKGROUND: Interventional diagnostic and therapeutic procedures requiring intravascular iodinated contrast steadily increase patient exposure to the risks of contrast-induced acute kidney injury (CIAKI), which is associated with death, nonfatal cardiovascular events, and prolonged hospitalization. The aim of this study was to investigate the efficacy of pharmacological and non-pharmacological treatments for CIAKI prevention in patients undergoing cardiovascular invasive procedures with iodinated contrast...
2017: PloS One
https://www.readbyqxmd.com/read/27931552/effects-of-sustained-release-trimetazidine-on-chronically-dysfunctional-myocardium-of-ischemic-dilated-cardiomyopathy-six-months-follow-up-result
#13
A Momen, M Ali, P K Karmakar, M Z Ali, A Haque, M R Khan, M I Khalil, M S Hossain, R M Huda, M N Goni
BACKGROUND: Ischemic cardiomyopathy is a growing burden in third world countries. So far, benefits of trimetazidine in this group of patients have been suggested by clinical trials mainly conducted in Europe. We evaluated the effect of trimetazidine on ischemic dilated cardiomyopathy in our population. METHODS AND RESULTS: 98 patients (aged 58.5±9.2 years), admitted with decompensated heart failure with previous history of MI and/or documentation of significant CAD with previous CAG, were chosen for the study...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931551/metabolic-manipulation-in-dilated-cardiomyopathy-assessing-the-role-of-trimetazidine
#14
Suman Jatain, Aditya Kapoor, Archana Sinha, Roopali Khanna, Sudeep Kumar, Naveen Garg, Satyendra Tewari, Pravin Goel
OBJECTIVES: To study the role of metabolic modulator (trimetazidine: TMZ) in dilated cardiomyopathy (DCM). Optimizing altered substrate metabolism in heart failure (HF) with metabolic modulators allows more efficacious energy production from glucose than from free fatty acids. METHODS: 100 patients of DCM (47.7 years, NYHA class 2.17, LVEF 27.3%) were randomized to TMZ (20mg tid, n=50) vs conventional therapy (n=50). Functional status, BNP and various echocardiographic parameters were assessed at 3-6 months...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27882023/effects-of-bisoprolol-in-combination-with-trimetazidine-on-the-treatment-of-heart-failure-and-concomitant-chronic-obstructive-pulmonary-disease
#15
Yuanyuan Ke, Dingli Xu, Minxiong Li, Zenglong Wu, Yongpeng Huang
OBJECTIVE: To evaluate the effects of bisoprolol combined with trimetazidine on the treatment of heart failure patients having concomitant chronic obstructive pulmonary disease (COPD); in comparison with control group treated with standard therapy only. METHODS: A total of 120 heart failure patients having concomitant COPD were selected and randomly divided into a control group and a treatment group according to different treatment methods (n=60). The control group was given continuous low flow oxygen inhalation and inotropic agents, and their cardiac stress was also reduced...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27855650/trimetazidine-attenuates-pressure-overload-induced-early-cardiac-energy-dysfunction-via-regulation-of-neuropeptide-y-system-in-a-rat-model-of-abdominal-aortic-constriction
#16
Ailan Chen, Wanglin Li, Xinyu Chen, Yuechun Shen, Wenjun Dai, Qi Dong, Xinchun Li, Caiwen Ou, Minsheng Chen
BACKGROUND: Metabolism remodeling has been recognized as an early event following cardiac pressure overload. However, its temporal association with ventricular hypertrophy has not been confirmed. Moreover, whether trimetazidine could favorably affect this process also needs to be determined. The aim of the study was to explore the temporal changes of myocardial metabolism remodeling following pressure-overload induced ventricular hypertrophy and the potential favorable effect of trimetazidine on myocardial metabolism remodeling...
November 17, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27803779/the-effect-of-oral-and-intraurethral-trimetazidine-use-on-urethral-healing
#17
Ali Ayyildiz, Sema Nur Ayyildiz, Erdal Benli, Havva Erdem, Selma Cirrik, Tevfik Noyan, R Cankon Germiyanoglu, Abdullah Çirakoglu
OBJECTIVES: We aimed to study the effect of trimetazidine (TMZ) on urethral wound repair. MATERIALS AND METHODS: A total of 52 male rats were used; 8 groups were formed: 1-week and 3-week control (C1, C3), sham (S1, S3), oral (OT1, OT3), and intraurethral TMZ (IUT1, IUT3) groups. Serum and urine total antioxidant capacity (TAC), total oxidant capacity (TOC), and 8-hydroxy-deoxy-guanosine (8-OHdG) were studied. Hematoxyline-Eosin was used for the histopathological study...
September 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27802805/erratum-to-early-administration-of-trimetazidine-attenuates-diabetic-cardiomyopathy-in-rats-by-alleviating-fibrosis-reducing-apoptosis-and-enhancing-autophagy
#18
Lei Zhang, Wen-Yuan Ding, Zhi-Hao Wang, Meng-Xiong Tang, Feng Wang, Ya Li, Ming Zhong, Yun Zhang, Wei Zhang
No abstract text is available yet for this article.
November 1, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27686005/emerging-drugs-for-the-treatment-of-angina-pectoris
#19
Cher-Rin Chong, Gao J Ong, John D Horowitz
Angina pectoris, or symptomatic myocardial ischaemia, reflects an impairment of coronary blood flow, and usually a deficiency of available myocardial energetics. Treatment options vary with the precise cause, which may vary with regards to the roles of increased myocardial oxygen demand versus reduced supply. Traditionally, organic nitrates, β-adrenoceptor antagonists, and non-dihydropyridine calcium antagonists were the only commonly used prophylactic anti-anginal agents. However, many patients failed to respond adequately to such therapy, and/or were unsuitable for their use...
December 2016: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/27678370/economic-evaluation-of-trimetazidine-in-the-management-of-chronic-stable-angina-in-greece
#20
Georgia Kourlaba, George Gourzoulidis, George Andrikopoulos, Konstantinos Tsioufis, Alexandra Beletsi, Nikos Maniadakis
BACKGROUND: To evaluate the cost-effectiveness of trimetazidine (TMZ) as add-on therapy to standard-of-care (SoC) compared to SoC alone in patients with chronic stable angina who did not respond adequately to first line therapy with b-blockers, nitrates or calcium channel antagonists in Greece. METHODS: A Markov model with 3-month cycles and 1-year time horizon was developed to assess the comparators. The analysis was conducted from a third-party payer perspective...
September 27, 2016: BMC Health Services Research
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