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https://www.readbyqxmd.com/read/28905537/the-relationship-between-airway-inflammation-and-exacerbation-in-chronic-obstructive-pulmonary-disease
#1
REVIEW
Diahn Warng Perng, Pei Ku Chen
Chronic obstructive pulmonary disease (COPD) is associated with abnormal inflammatory response and airflow limitation. Acute exacerbation involves increased inflammatory burden leading to worsening respiratory symptoms, including dyspnea and sputum production. Some COPD patients have frequent exacerbations (two or more exacerbations per year). A substantial proportion of COPD patients may remain stable without exacerbation. Bacterial and viral infections are the most common causative factors that breach airway stability and lead to exacerbation...
September 4, 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28892934/why-do-patients-undergoing-chronic-obstructive-pulmonary-disease-treatment-turn-defaulters-a-follow-up-study-in-a-tertiary-care-hospital-in-jamnagar-india
#2
Amrita Sarkar, Abhay Javia, Pradeep Pithadia, Dipesh Parmar
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD), a progressive respiratory illness requiring long-term treatment, is a significant cause of morbidity, mortality and economic burden on the family as well as the country. In the tertiary health care facility where the study was carried out, it was observed that many COPD patients did not come for regular follow up. In these patients, treatment interruption may lead to increased morbidity and mortality. AIM: This study aimed to find out the reasons for defaulting follow up and treatment in COPD patients...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28889106/prevention-of-copd-exacerbations-a-european-respiratory-society-american-thoracic-society-guideline
#3
Jadwiga A Wedzicha, Peter M A Calverley, Richard K Albert, Antonio Anzueto, Gerard J Criner, John R Hurst, Marc Miravitlles, Alberto Papi, Klaus F Rabe, David Rigau, Pawel Sliwinski, Thomy Tonia, Jørgen Vestbo, Kevin C Wilson, Jerry A Krishnan
This document provides clinical recommendations for the prevention of chronic obstructive pulmonary disease (COPD) exacerbations. It represents a collaborative effort between the European Respiratory Society and the American Thoracic Society.Comprehensive evidence syntheses were performed to summarise all available evidence relevant to the Task Force's questions. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach and the results were summarised in evidence profiles...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28875459/once-daily-triple-therapy-in-patients-with-advanced-copd-healthcare-resource-utilization-data-and-associated-costs-from-the-fulfil-trial
#4
Afisi S Ismaila, Ruby Birk, Dhvani Shah, Shiyuan Zhang, Noushin Brealey, Nancy A Risebrough, Maggie Tabberer, Chang-Qing Zhu, David A Lipson
INTRODUCTION: Chronic obstructive pulmonary disease is associated with a high healthcare resource and cost burden. Healthcare resource utilization was analyzed in patients with symptomatic chronic obstructive pulmonary disease at risk of exacerbations in the FULFIL study. Patients received either once-daily, single inhaler triple therapy (fluticasone furoate/umeclidinium/vilanterol) 100 µg/62.5 µg/25 µg or twice-daily dual inhaled corticosteroid/long-acting beta agonist therapy (budesonide/formoterol) 400 µg/12 µg...
September 5, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28869224/evaluation-of-tuberculosis-associated-chronic-obstructive-pulmonary-disease-at-a-tertiary-care-hospital-a-case-control-study
#5
Deepak Aggarwal, Anubhav Gupta, A K Janmeja, Manisha Bhardwaj
CONTEXT: Irreversible airway obstruction is important sequelae of pulmonary tuberculosis (TB) that might contribute to a significant proportion of chronic obstructive pulmonary disease (COPD). India has the highest TB burden in the world. However, there are limited data on the prevalence and presentation of TB-associated COPD from this region. AIMS: This study aims to evaluate the prevalence of TB-associated COPD among COPD patients presenting to a tertiary care hospital...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28862879/chronic-obstructive-pulmonary-disease-in-hispanics-a-9-year-update
#6
Alejandro Díaz, Bartolomé Celli, Juan C Celedón
Hispanics are the largest minority in the U.S., now encompassing 56.6 million people. A Hispanic or Latino is an individual whose ancestry can be traced to Spain or territories previously under Spanish control. The Hispanic population in the U.S. and Latin America is very diverse for country of origin, nativity, and racial ancestry. Over the last nine years, our knowledge of COPD in Hispanics has improved, due to a better understanding of differences in COPD burden and risk factors across Hispanic subgroups, development of subgroup-specific spirometry reference equations, genetic studies, and better knowledge of barriers and needs in the diagnosis and management of COPD in the Hispanic population...
September 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28860735/skin-condition-and-its-relationship-to-systemic-inflammation-in-chronic-obstructive-pulmonary-disease
#7
Sebastian Majewski, Anna Pietrzak, Damian Tworek, Karolina Szewczyk, Anna Kumor-Kisielewska, Zofia Kurmanowska, Paweł Górski, Anna Zalewska-Janowska, Wojciech Jerzy Piotrowski
BACKGROUND: The systemic (extrapulmonary) effects and comorbidities of chronic obstructive pulmonary disease (COPD) contribute substantially to its burden. The supposed link between COPD and its systemic effects on distal organs could be due to the low-grade systemic inflammation. The aim of this study was to investigate whether the systemic inflammation may influence the skin condition in COPD patients. MATERIALS AND METHODS: Forty patients with confirmed diagnosis of COPD and a control group consisting of 30 healthy smokers and 20 healthy never-smokers were studied...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28856801/high-rates-of-respiratory-symptoms-and-airways-disease-in-mental-health-inpatients-in-a-tertiary-centre
#8
Andrew J Burke, Karen Hay, Alex Chadwick, Dan Siskind, Judith Sheridan
BACKGROUND: People with severe mental illness (SMI) have a lower life expectancy in part due to a higher prevalence of cardiac and metabolic disease. Less is known of the prevalence of respiratory disease in this group. AIMS: This cross sectional, observational study aimed to assess the prevalence of symptoms associated with respiratory disease in patients admitted to an inpatient mental health unit. METHODS: A convenience sample of eighty-two inpatients had a structured interview and questionnaire completed...
August 30, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28851860/a-qualitative-study-of-gp-nurse-and-practice-manager-views-on-using-targeted-case-finding-to-identify-patients-with-copd-in-primary-care
#9
Rachael H Summers, Taniya Sharmeen, Kate Lippiett, Kate Gillett, Carla Astles, Linh Vu, Mark Stafford-Watson, Anne Bruton, Mike Thomas, Tom Wilkinson
'Finding the missing millions' with chronic obstructive pulmonary disease became part of the Department of Health strategy for England in 2010. Targeted case-finding within primary care is one potential pro-active strategy, but currently little is known about the views of healthcare professionals on this approach. In this study, 36 healthcare professionals (12 GPs, 14 nurses, and 10 practice managers) from 34 UK practices participated in semi-structured telephone interviews about targeted case-finding. Interviews followed an interview guide, were audio-recorded, transcribed verbatim, coded and analysed using 'Framework Approach'...
August 29, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28846483/palliative-care-needs-in-an-acute-internal-medicine-ward-in-mexico
#10
Tania Zertuche-Maldonado, Rodrigo Tellez-Villarreal, Antonio Pascual, Salvador B Valdovinos-Chavez, Abel Jesus Barragan-Berlanga, Maria Teresa Sanchez-Avila, Leonardo Bracho-Vela, Adria Tinoco-Aranda, Eduardo Bruera
BACKGROUND: Palliative care is an evolving but underdeveloped practice in Mexico. OBJECTIVE: The primary end point of this prospective observational study was to identify internal medicine inpatients fulfilling advanced criteria within a second-level hospital. Secondary end points were symptom burden, treatment, resource utilization, and one-year survival. DESIGN AND MEASUREMENTS: The 390-sample size calculation was based on previous studies where 15% of inpatients fulfilled palliative care needs...
August 28, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28839989/factors-affecting-satisfaction-with-education-program-for-chronic-airway-disease-in-primary-care-settings
#11
Andrew Kim, Yong Il Hwang, Joo Hee Kim, Seung Hun Jang, Sunghoon Park, Ji Young Park, Ki-Suck Jung, Kwang Ha Yoo, Yong Bum Park, Hyoung Kyu Yoon, Chin Kook Rhee, Deog Kyeom Kim, Ho-Kee Yum
BACKGROUND: A well-organized education program improved the patients' knowledge about their disease, inhaler technique and quality of life in asthma and chronic obstructive pulmonary disease (COPD) patients. The effectiveness of the education program can be evaluated by assessing patients' satisfaction with the education program as well. In this study, we compared the patients' satisfaction with education program between COPD and asthma patients. METHODS: A total of 284 asthma and COPD patients were enrolled...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28831249/multicenter-study-of-the-copd-6-screening-device-feasible-for-early-detection-of-chronic-obstructive-pulmonary-disease-in-primary-care
#12
Peter Kjeldgaard, Jesper Lykkegaard, Heidi Spillemose, Charlotte Suppli Ulrik
BACKGROUND AND AIM: Early detection of COPD may reduce the future burden of the disease. We aimed to investigate whether prescreening with a COPD-6 screening device (measuring FEV1 and FEV6) facilitates early detection of COPD in primary care. METHODS: In primary care, individuals at high risk of COPD (ie, age ≥35 years, relevant exposure, and at least one respiratory symptom) and no previous diagnosis of obstructive lung disease were examined with a COPD-6 screening device...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28831247/validity-of-physician-diagnosed-copd-in-relation-to-spirometric-definitions-of-copd-in-a-general-population-aged-50-64-years-the-scapis-pilot-study
#13
Kjell Torén, Nicola Murgia, Anna-Carin Olin, Jan Hedner, John Brandberg, Annika Rosengren, Göran Bergström
BACKGROUND: In epidemiological studies, items about physician-diagnosed COPD are often used. There is a lack of validation and standardization of these items. MATERIALS AND METHODS: In a general population-based study, 1,050 subjects completed a questionnaire and performed spirometry, including forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) after inhalation of 400 µg of salbutamol. COPD was defined as the ratio of FEV1/FVC <0.7 after bronchodilation...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28830839/the-potential-for-targeted-rewriting-of-epigenetic-marks-in-copd-as-a-new-therapeutic-approach
#14
REVIEW
Dan-Dan Wu, Juan Song, Sabine Bartel, Susanne Krauss-Etschmann, Marianne G Rots, Machteld N Hylkema
Chronic obstructive pulmonary disease (COPD) is an age and smoking related progressive, pulmonary disorder presenting with poorly reversible airflow limitation as a result of chronic bronchitis and emphysema. The prevalence, disease burden for the individual, and mortality of COPD continues to increase, whereas no effective treatment strategies are available. For many years now, a combination of bronchodilators and anti-inflammatory corticosteroids has been most widely used for therapeutic management of patients with persistent COPD...
August 19, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28822787/global-regional-and-national-deaths-prevalence-disability-adjusted-life-years-and-years-lived-with-disability-for-chronic-obstructive-pulmonary-disease-and-asthma-1990-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#15
(no author information available yet)
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods and disease and risk estimates for COPD and asthma from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2015 study. The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year...
September 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28799856/severity-of-airflow-obstruction-in-chronic-obstructive-pulmonary-disease-copd-proposal-for-a-new-classification
#16
Sonia Coton, William M Vollmer, Eric Bateman, Guy B Marks, Wan Tan, Filip Mejza, Sanjay Juvekar, Christer Janson, Kevin Mortimer, Mahesh P A, A Sonia Buist, Peter G J Burney
Current classifications of Chronic Obstructive Pulmonary Disease (COPD) severity are complex and do not grade levels of obstruction. Obstruction is a simpler construct and independent of ethnicity. We constructed an index of obstruction severity based on the FEV1/FVC ratio, with cut-points dividing the Burden of Obstructive Lung Disease (BOLD) study population into four similarly sized strata to those created by the GOLD criteria that uses FEV1. We measured the agreement between classifications and the validity of the FEV1-based classification in identifying the level of obstruction as defined by the new groupings...
August 11, 2017: COPD
https://www.readbyqxmd.com/read/28790817/emerging-pharmaceutical-therapies-for-copd
#17
REVIEW
Sowmya P Lakshmi, Aravind T Reddy, Raju C Reddy
COPD, for which cigarette smoking is the major risk factor, remains a worldwide burden. Current therapies provide only limited short-term benefit and fail to halt progression. A variety of potential therapeutic targets are currently being investigated, including COPD-related proinflammatory mediators and signaling pathways. Other investigational compounds target specific aspects or complications of COPD such as mucus hypersecretion and pulmonary hypertension. Although many candidate therapies have shown no significant effects, other emerging therapies have improved lung function, pulmonary hypertension, glucocorticoid sensitivity, and/or the frequency of exacerbations...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28758310/the-global-burden-of-respiratory-infections-in-indigenous-children-and-adults-a-review
#18
REVIEW
Thilini L Basnayake, Lucy C Morgan, Anne B Chang
This review article focuses on common lower respiratory infections (LRIs) in indigenous populations in both developed and developing countries, where data is available. Indigenous populations across the world share some commonalities including poorer health and socio-economic disadvantage compared with their non-indigenous counterparts. Generally, acute and chronic respiratory infections are more frequent and more severe in both indigenous children and adults, often resulting in substantial consequences including higher rates of bronchiectasis and poorer outcomes for patients with chronic obstructive pulmonary disease (COPD)...
July 30, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28751416/excess-economic-burden-of-comorbidities-in-copd-a-15-year-population-based-study
#19
Wenjia Chen, J Mark FitzGerald, Don D Sin, Mohsen Sadatsafavi
A better understanding of the true burden of chronic obstructive pulmonary disease (COPD) needs to consider the implications of comorbidities. This study comprehensively examined the impact of comorbidities on excess direct medical costs in COPD patients.From health administrative data in British Columbia, Canada (1996-2012), we created a propensity-score-matched cohort of incident COPD patients and individuals without COPD. Health services use records were compiled into 16 major disease categories based on International Classification of Diseases codes...
July 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28751367/imaging-approaches-to-understand-disease-complexity-chronic-obstructive-pulmonary-disease-as-a-clinical-model
#20
Karin Jc Sanders, Samuel Y Ash, George R Washko, Felix M Mottaghy, Annemie M W J Schols
The clinical manifestations of chronic obstructive pulmonary disease (COPD) reflect an aggregate of multiple pulmonary and extra-pulmonary processes. It is increasingly clear that full assessment of these processes is essential to characterize disease burden and to tailor therapy. Medical imaging has advanced such that it is now possible to obtain in vivo insight in the presence and severity of lung disease associated features. In this review we have assembled data from multiple disciplines of medical imaging research to review the role of imaging in characterization of COPD...
July 27, 2017: Journal of Applied Physiology
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