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https://www.readbyqxmd.com/read/27890989/the-burden-of-segregated-respiratory-diseases-in-india-and-the-quality-of-care-in-these-patients-results-from-the-asia-pacific-burden-of-respiratory-diseases-study
#1
Aloke Gopal Ghoshal, G D Ravindran, Paras Gangwal, Girish Rajadhyaksha, Sang-Heon Cho, Abdul Razak Bin Abdul Muttalif, Horng-Chyuan Lin, Sanguansak Thanaviratananich, Shalini Bagga, Rab Faruqi, Shiva Sajjan, Pradeep Shetty, Raeesuddin Syed, Kim K Hamrosi, De Yun Wang
BACKGROUND: Chronic respiratory diseases such as asthma, allergic rhinitis (AR), chronic obstructive pulmonary disease (COPD), and rhinosinusitis are becoming increasingly prevalent in the Asia-Pacific region. The Asia-Pacific Burden of Respiratory Diseases study examined the disease and economic burden of AR, asthma, COPD, and rhinosinusitis across the Asia-Pacific and more specifically India. OBJECTIVES: To estimate the proportion of adults receiving care for asthma, AR, COPD, and rhinosinusitis and assess the economic burden, both direct and indirect of these chronic respiratory disease...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27888995/efficacy-of-non-invasive-ventilation-as-a-rescue-therapy-for-relieving-dyspnea-in-patients-with-stable-severe-copd
#2
Yong-Er Ou, Zhi-Min Lin, Wei-Liang Wu, Qun Luo, Rong-Chang Chen
Exertional Dyspnea is a troublesome symptom in chronic obstructive pulmonary disease (COPD) even after optimal therapy, which is a physiological and perceptional burden to limit their activities. Non-invasive ventilation (NIV) might provide rescue therapy for this population to relieve exertional dyspnea. This was a randomized crossover study in 18 patients with stable severe COPD. Exertional dyspnea was induced with maximal symptom-limited incremental cycle exercise. Then the patients would randomly receive oxygen or NIV plus oxygen therapy...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27886849/prevalence-and-burden-of-comorbidities-in-chronic-obstructive-pulmonary-disease
#3
REVIEW
Alexandru Corlateanu, Serghei Covantev, Alexander G Mathioudakis, Victor Botnaru, Nikolaos Siafakas
The classical definition of Chronic Obstructive Pulmonary Disease (COPD) as a lung condition characterized by irreversible airway obstruction is outdated. The systemic involvement in patients with COPD, as well as the interactions between COPD and its comorbidities, justify the description of chronic systemic inflammatory syndrome. The pathogenesis of COPD is closely linked with aging, as well as with cardiovascular, endocrine, musculoskeletal, renal, and gastrointestinal pathologies, decreasing the quality of life of patients with COPD and, furthermore, complicating the management of the disease...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27881915/copd-care-delivery-pathways-in-five-european-union-countries-mapping-and-health-care-professionals-perceptions
#4
Reem Kayyali, Bassel Odeh, Inéz Frerichs, Nikki Davies, Eleni Perantoni, Shona D'arcy, Anouk W Vaes, John Chang, Martijn A Spruit, Brenda Deering, Nada Philip, Roshan Siva, Evangelos Kaimakamis, Ioanna Chouvarda, Barbara Pierscionek, Norbert Weiler, Emiel Fm Wouters, Andreas Raptopoulos, Shereen Nabhani-Gebara
BACKGROUND: COPD is among the leading causes of chronic morbidity and mortality in the European Union with an estimated annual economic burden of €25.1 billion. Various care pathways for COPD exist across Europe leading to different responses to similar problems. Determining these differences and the similarities may improve health and the functioning of health services. OBJECTIVE: The aim of this study was to compare COPD patients' care pathway in five European Union countries including England, Ireland, the Netherlands, Greece, and Germany and to explore health care professionals' (HCPs) perceptions about the current pathways...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27861566/findings-on-thoracic-computed-tomography-scans-and-respiratory-outcomes-in-persons-with-and-without-chronic-obstructive-pulmonary-disease-a-population-based-cohort-study
#5
Wan C Tan, Cameron J Hague, Jonathon Leipsic, Jean Bourbeau, Liyun Zheng, Pei Z Li, Don D Sin, Harvey O Coxson, Miranda Kirby, James C Hogg, Rekha Raju, Jeremy Road, Denis E O'Donnell, Francois Maltais, Paul Hernandez, Robert Cowie, Kenneth R Chapman, Darcy D Marciniuk, J Mark FitzGerald, Shawn D Aaron
BACKGROUND: Thoracic computed tomography (CT) scans are widely performed in clinical practice, often leading to detection of airway or parenchymal abnormalities in asymptomatic or minimally symptomatic individuals. However, clinical relevance of CT abnormalities is uncertain in the general population. METHODS: We evaluated data from 1361 participants aged ≥40 years from a Canadian prospective cohort comprising 408 healthy never-smokers, 502 healthy ever-smokers, and 451 individuals with spirometric evidence of chronic obstructive pulmonary disease (COPD) who had thoracic CT scans...
2016: PloS One
https://www.readbyqxmd.com/read/27853654/tumor-necrosis-factor-links-chronic-obstructive-pulmonary-disease-and-k-ras-mutant-lung-cancer-through-induction-of-an-immunosuppressive-pro-tumor-microenvironment
#6
Lei Gong, Mauricio da Silva Caetano, Amber M Cumpian, Soudabeh Daliri, Alejandra Garza Flores, Seon Hee Chang, Cesar E Ochoa, Christopher M Evans, Zhentao Yu, Seyed Javad Moghaddam
Tumor necrosis factor (TNF) is known as an important regulator of tumor microenvironment and inflammation. TNF levels are markedly elevated in the bronchoalveolar lavage fluid (BALF) of patients with chronic obstructive pulmonary disease (COPD), which is an independent risk factor for lung cancer. We have previously shown that COPD-like airway inflammation promotes lung cancer in a K-ras mutant mouse model (CC-LR mouse). This was associated with a significant increase of neutrophils in BALF, accompanied by a marked increase in TNF level, suggesting a link between COPD, TNF, and lung cancer promotion...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27853362/comparative-analysis-of-budesonide-formoterol-and-fluticasone-salmeterol-combinations-in-copd-patients-findings-from-a-real-world-analysis-in-an-italian-setting
#7
Valentina Perrone, Diego Sangiorgi, Stefano Buda, Luca Degli Esposti
AIM: The objective of this study was to evaluate the different outcomes associated with the use of budesonide/formoterol compared to fluticasone/salmeterol in fixed combinations in patients with COPD in a "real-world" setting. The outcomes included exacerbation rates and health care costs. PATIENTS AND METHODS: An observational retrospective cohort analysis, based on administrative databases of three local health units, was conducted. Patients with at least one prescription of fixed-dose combination of inhaled corticosteroids and long-acting β2-agonists (budesonide/formoterol or fluticasone/salmeterol), at dosages and formulations approved for COPD in Italy, between January 1, 2009 and December 31, 2011 (inclusion period), were included...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27853139/-to-use-or-not-to-use-a-qualitative-study-to-evaluate-experiences-of-healthcare-providers-and-patients-with-the-assessment-of-burden-of-copd-abc-tool
#8
Annerika H M Slok, Mascha Twellaar, Leslie Jutbo, Daniel Kotz, Niels H Chavannes, Sebastiaan Holverda, Philippe L Salomé, P N Richard Dekhuijzen, Maureen P M H Rutten-van Mölken, Denise Schuiten, Johannes C C M In 't Veen, Onno C P van Schayck
In the management of chronic conditions, such as chronic obstructive pulmonary disease (COPD), there is a shift from doctor-driven care to patient-centred integrated care with active involvement of and self-management by the patient. A recently developed tool, the assessment of burden of COPD (ABC) tool, can be used in this transition to facilitate self-management support and shared decision-making. We performed a qualitative study, in which we collected and analysed the data using the methods of conventional content analyses...
November 17, 2016: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/27843852/prevalence-of-chronic-respiratory-disorders-in-a-rural-area-of-north-west-india-a-population-based-study
#9
Vinod Sharma, Rajiv Kumar Gupta, D S Jamwal, Sunil Kumar Raina, Bhavana Langer, Rashmi Kumari
INTRODUCTION: Chronic respiratory diseases are an important cause of disability across the globe. The global burden of these diseases is showing a discernible upward trend. It is estimated that 500 million people suffer from them. MATERIALS AND METHODS: The study was conducted with the aim to estimate the prevalence of chronic obstructive pulmonary disease (COPD) in a rural Indian population. For this, a population-based survey was conducted using modified British Medical Research Council questionnaire...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27843851/predictors-of-outcome-in-patients-admitted-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-in-a-rural-tertiary-care-center
#10
Abraham M Ittyachen, Smitha Krishnamoorthy, Arun N Bhatt, Shanavas Abdulla, Jijo Oommen Roy, M Sugathan, Kevin Ambadan, Jelty Kuriakose
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with a high degree of mortality and morbidity around the world with the burden of the disease being more in the developing countries. In the Indian context data is limited. This study was carried out to determine the predictors of outcome in patients admitted with acute exacerbation of COPD in a rural Tertiary Care Center in the state of Kerala. MATERIALS AND METHODS: This was a prospective cohort study...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27842552/circulating-biomarkers-of-oxidative-stress-in-chronic-obstructive-pulmonary-disease-a-systematic-review
#11
REVIEW
Elisabetta Zinellu, Angelo Zinellu, Alessandro Giuseppe Fois, Ciriaco Carru, Pietro Pirina
Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airflow limitation associated with an abnormal inflammatory response of the lungs to noxious particles and gases, caused primarily by cigarette smoking. Increased oxidative burden plays an important role in the pathogenesis of COPD. There is a delicate balance between the toxicity of oxidants and the protective function of the intracellular and extracellular antioxidant defense systems, which is critically important for the maintenance of normal pulmonary functions...
November 14, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27823697/impact-of-chronic-obstructive-pulmonary-disease-on-prognosis-in-atrial-fibrillation-a-report-from-the-eurobservational-research-programme-pilot-survey-on-atrial-fibrillation-eorp-af-general-registry
#12
Marco Proietti, Cécile Laroche, Marcin Drozd, Johan Vijgen, Dragos C Cozma, Jaroslaw Drozdz, Aldo P Maggioni, Giuseppe Boriani, Gregory Y H Lip
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common chronic disease, being associated with both high rates of morbidity and mortality. Similarly, atrial fibrillation (AF) is associated with a higher risk of both cardiovascular (CV) events and overall mortality. The AF and COPD often coexist, but the impact of COPD on prognosis in European AF patients is unknown. METHODS: We evaluated COPD prevalence in patients enrolled in the EURObservational Research Programme Pilot Survey on Atrial Fibrillation Registry Pilot Phase...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27822028/effect-of-endurance-versus-resistance-training-on-quadriceps-muscle-dysfunction-in-copd-a-pilot-study
#13
Ulrik Winning Iepsen, Gregers Druedal Wibe Munch, Mette Rugbjerg, Anders Rasmussen Rinnov, Morten Zacho, Stefan Peter Mortensen, Niels H Secher, Thomas Ringbaek, Bente Klarlund Pedersen, Ylva Hellsten, Peter Lange, Pia Thaning
INTRODUCTION: Exercise is an important countermeasure to limb muscle dysfunction in COPD. The two major training modalities in COPD rehabilitation, endurance training (ET) and resistance training (RT), may both be efficient in improving muscle strength, exercise capacity, and health-related quality of life, but the effects on quadriceps muscle characteristics have not been thoroughly described. METHODS: Thirty COPD patients (forced expiratory volume in 1 second: 56% of predicted, standard deviation [SD] 14) were randomized to 8 weeks of ET or RT...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27821164/the-evaluation-of-a-remote-support-program-on-quality-of-life-and-evolution-of-disease-in-copd-patients-with-frequent-exacerbations
#14
Bernardino Alcazar, Pilar de Lucas, Joan B Soriano, Alonso Fernández-Nistal, Antonia Fuster, Jose Miguel Rodríguez González-Moro, Aurelio Arnedillo, Patricia García Sidro, María José Espinosa de Los Monteros
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients often present considerable individual medical burden in their symptoms, limitations, and well-being that complicate medical treatment. To improve their overall health status, while reducing the number of exacerbations, a multidisciplinary approach including different elements of care is needed. The aim of this study was to evaluate the effects of a remote support program on COPD patients at high risk of experiencing worsening of their disease and other health-related outcomes...
November 8, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27819513/can-assessment-of-disease-burden-prior-to-changes-in-initial-copd-maintenance-treatment-provide-insight-into-remaining-unmet-needs-a-retrospective-database-study-in-uk-primary-care
#15
Sarah H Landis, Keele Wurst, Hoa Van Le, Kerina Bonar, Yogesh S Punekar
This retrospective cohort study aimed to assess treatment patterns over 24 months amongst patients with chronic obstructive pulmonary disease (COPD), initiating a new COPD maintenance treatment, and to understand clinical indicators of treatment change. Patients included in the study initiated a long-acting β2-agonist (LABA), a long-acting muscarinic antagonist (LAMA), or a combination of LABA and an inhaled corticosteroid (ICS/LABA) between January 1, 2009, and November 30, 2013, as recorded in the United Kingdom Clinical Practice Research Datalink (UK CPRD)...
November 7, 2016: COPD
https://www.readbyqxmd.com/read/27816445/improving-the-management-of-copd-in-women
#16
REVIEW
Christine R Jenkins, Kenneth R Chapman, James F Donohue, Nicolas Roche, Ioanna Tsiligianni, MeiLan K Han
Chronic obstructive pulmonary disease (COPD) is a highly debilitating disease that represents a substantial and growing health burden in women. There is increasing evidence for gender-related differences in COPD risk, progression and outcomes. However, the disease receives scant attention as a women's health issue. Thus, a multifaceted approach is required to address COPD in women, including greater awareness, minimisation of risk and further elucidation of the gender-specific factors (biological and cultural) that affect risk, disease progression and treatment success...
November 2, 2016: Chest
https://www.readbyqxmd.com/read/27806533/epidemiologic-correlates-of-chronic-respiratory-infections-in-adults-an-urban-slum-of-bhubaneswar-odisha-india
#17
Sonali Kar, Ipsa Mohapatra, Amrita Konar
INTRODUCTION: Urbanization is marked by emergence of slum areas, wherein migrants from the nearby villages stay in temporary establishments for seeking avenues of employment. These dwellings lack most of the essential living conditions like safe water, healthy living conditions and access to health services. This population is also vulnerable to social evils like alcohol and tobacco addiction. KIMS, a medical college in Bhubaneswar, Odisha, India has an Urban Health Training Centre (UHTC) that caters to a slum population of nearly 12,000 population for their primary health needs...
August 4, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27805538/-effectiveness-of-the-assessment-of-burden-of-copd-tool-a-cluster-randomised-controlled-trial
#18
O C P van Schayck, A H M Slok, D Kotz, G van Breukelen, N H Chavannes, M P M H Rutten-van Mölken, H A M Kerstjens, T van der Molen, G M Asijee, P N R Dekhuijzen, S Holverda, P L Salomé, L M A Goossens, M Twellaar, J C C M In 't Veen
OBJECTIVE: Assessment of the effectiveness of the Assessment of Burden of COPD (ABC) tool on disease-specific quality of life in patients with Chronic Obstructive Pulmonary Disease (COPD). DESIGN: Cluster-randomised controlled trial. METHOD: This concerned a trial in 39 Dutch primary care practices and 17 hospitals, involving 357 patients with COPD (postbronchodilator FEV1/FVC ratio < 0.7) aged ≥ 40 years. Healthcare providers were randomized to an intervention or control group...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27799761/costs-of-chronic-obstructive-pulmonary-disease-in-urban-areas-of-china-a-cross-sectional-study-in-four-cities
#19
Xiaoying Chen, Na Wang, Yue Chen, Tian Xiao, Chaowei Fu, Biao Xu
PURPOSE: The economic burden of COPD has not been well studied in China. This study investigated the total costs caused by COPD and the influencing factors for the high economic burden in urban areas of China. PATIENTS AND METHODS: A cross-sectional study was carried out among 678 COPD patients in four cities in China in 2011. The average annual direct medical costs (DMCs), direct nonmedical costs (DNMCs), and indirect costs (ICs) on COPD were measured by median and mean (± standard deviation)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27795984/pulmonary-predictors-of-incident-diabetes-in-smokers
#20
Gregory L Kinney, Emma H Baker, Oana L Klein, Jennifer L Black-Shinn, Emily S Wan, Barry Make, Elizabeth Regan, Russell P Bowler, Sharon M Lutz, Kendra A Young, Lindsey M Duca, George R Washko, Edwin K Silverman, James D Crapo, John E Hokanson
BACKGROUND: Diabetes mellitus and its complications are a large and increasing burden for health care worldwide. Reduced pulmonary function has been observed in diabetes (both type 1 and type 2), and this reduction is thought to occur prior to diagnosis. Other measures of pulmonary health are associated with diabetes, including lower exercise tolerance, greater dyspnea, lower quality of life (as measured by the St. George's Respiratory Questionaire [SGRQ]) and susceptibility to lung infection and these measures may also predate diabetes diagnosis...
2016: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
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