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https://www.readbyqxmd.com/read/28740375/clinical-and-economic-burden-of-dyspnea-and-other-copd-symptoms-in-a-managed-care-setting
#1
Judith J Stephenson, Debra Wertz, Tao Gu, Jeetvan Patel, Anand A Dalal
PURPOSE: The degree to which symptoms such as dyspnea affect patients with COPD is individualized. To address the gap between clinical symptom measures and self-perceived disease burden, we investigated the symptom status of adult patients with COPD and followed with an administrative claims analysis of health care resource utilization and costs. METHODS: This was a hybrid US observational study consisting of a cross-sectional patient survey followed by a retrospective analysis of administrative claims data...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28732818/adherence-to-copd-treatment-myth-and-reality
#2
REVIEW
Paola Rogliani, Josuel Ora, Ermanno Puxeddu, Maria Gabriella Matera, Mario Cazzola
COPD is a chronic disease in which effective management requires long-term adherence to pharmacotherapies but the level of adhesion to the prescribed medications is very low and this has a negative influence on outcomes. There are several approaches to detect non-adherence, such as pharmacy refill methods, electronic monitoring, and self-report measures, but they are all burdened with important limitations. Medication adherence in COPD is multifactorial and is affected by patients (health beliefs, cognitive abilities, self-efficacy, comorbidities, psychological profile, conscientiousness), physicians (method of administration, dosing regimen, polypharmacy, side effects), and society (patient-prescriber relationship, social support, access to medication, device training, follow-up)...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28721079/burden-of-air-leak-complications-in-thoracic-surgery-estimated-using-a-national-hospital-billing-database
#3
Andrew Yoo, Sudip K Ghosh, Walter Danker, Edmund Kassis, Iftekhar Kalsekar
BACKGROUND: One of the most common outcomes of lung resections are parenchymal air leaks. These air leaks are most often self-limited and spontaneously resolve several days after surgery. Historically, only prolonged air leaks have been considered to have a significant effect on patient outcomes. This study aims to evaluate the impact of any air leak complications (aALCs) on resource utilization and mortality. METHODS: The Premier Perspective(®) database was used to identify all elective primary lobectomy, segmentectomy, and wedge resections performed from 2012 to 2014; aALC was defined as a composite of air leak and pneumothorax...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28720336/baseline-symptom-score-impact-on-benefits-of-glycopyrrolate-formoterol-mdi-in-copd
#4
Fernando J Martinez, Leonardo M Fabbri, Gary T Ferguson, Chad Orevillo, Patrick Darken, Ubaldo J Martin, Colin Reisner
BACKGROUND: Chronic obstructive pulmonary disease (COPD) clinical severity is presently categorized by symptom burden and exacerbation risk. Previous 24-week Phase III trials (NCT01854645 and NCT01854658) that demonstrated better improvement of lung function with GFF MDI, a metered dose inhaler fixed-dose combination of glycopyrrolate/formoterol fumarate 18/9.6 μg, over individual monocomponent MDIs included a cross-section of patients with moderate-to-very severe airflow limitation and a broad range of COPD symptoms...
July 15, 2017: Chest
https://www.readbyqxmd.com/read/28713217/the-burden-of-illness-related-to-chronic-obstructive-pulmonary-disease-exacerbations-in-qu%C3%A3-bec-canada
#5
Tam Dang-Tan, Shiyuan Zhang, Ruben V Tavares, Melissa Stutz, Afisi S Ismaila, Julie Vaillancourt, Diane Corriveau, Richard H Stanford, Xiwu Lin, Gilbert A Nadeau, Alexander Simidchiev, Daria Parsons, John S Sampalis
BACKGROUND: Chronic obstructive pulmonary disease (COPD) prevalence in Canada has risen over time. COPD-related exacerbations contribute to the increased health care utilization (HCU) in this population. This study investigated the impact of exacerbations on COPD-related HCU. METHODS: This retrospective observational cohort study used patient data from the Québec provincial health insurance databases. Eligible patients with a new HCU claim with a diagnostic billing for COPD during 2001-2010 were followed until March 31, 2011...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28707495/individualizing-the-selection-of-long-acting-bronchodilator-therapy-for-patients-with-copd-considerations-in-primary-care
#6
Brian W Carlin, Sandra K Schuldheisz, Imre Noth, Gerard J Criner
Chronic obstructive pulmonary disease (COPD) is a common condition encountered in primary care settings. COPD remains the third leading cause of death in the United States and carries a significant burden to both patients and the healthcare system. COPD is a chronic, progressive, irreversible lung disease associated with high morbidity and mortality. Proper assessment and diagnosis requires spirometry which is currently underutilized in primary care. Management is focused on adequate symptom control, improving quality of breathing and quality of life, and preventing exacerbations and hospitalizations...
July 24, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28687678/occupational-exposure-to-pesticides-are-associated-with-fixed-airflow-obstruction-in-middle-age
#7
Sheikh M Alif, Shyamali C Dharmage, Geza Benke, Martine Dennekamp, John A Burgess, Jennifer L Perret, Caroline J Lodge, Stephen Morrison, David Peter Johns, Graham G Giles, Lyle C Gurrin, Paul S Thomas, John Llewelyn Hopper, Richard Wood-Baker, Bruce R Thompson, Iain H Feather, Roel Vermeulen, Hans Kromhout, E Haydn Walters, Michael J Abramson, Melanie Claire Matheson
RATIONALE: Population-based studies have found evidence of a relationship between occupational exposures and Chronic Obstructive Pulmonary Disease (COPD), but these studies are limited by the use of prebronchodilator spirometry. Establishing this link using postbronchodilator is critical, because occupational exposures are a modifiable risk factor for COPD. OBJECTIVES: To investigate the associations between occupational exposures and fixed airflow obstruction using postbronchodilator spirometry...
July 7, 2017: Thorax
https://www.readbyqxmd.com/read/28684907/anti-p-benzoquinone-antibody-level-as-a-prospective-biomarker-to-identify-smokers-at-risk-for-copd
#8
Santanu Banerjee, Parthasarathi Bhattacharyya, Subhra Mitra, Somenath Kundu, Samiran Panda, Indu B Chatterjee
BACKGROUND AND OBJECTIVE: Identification of smokers having predisposition to COPD is important for early intervention to reduce the huge global burden of the disease. Using a guinea pig model, we have shown that p-benzoquinone (p-BQ) derived from cigarette smoke (CS) in the lung is a causative factor for CS-induced emphysema. p-BQ is also derived from CS in smokers and it elicits the production of anti-p-BQ antibody in humans. We therefore hypothesized that anti-p-BQ antibody might have a protective role against COPD and could be used as a predictive biomarker for COPD in smokers...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28680574/chronic-use-of-pah-specific-therapy-in-world-health-organization-group-iii-pulmonary-hypertension-a-systematic-review-and-meta-analysis
#9
Kurt W Prins, Sue Duval, Jeremy Markowitz, Marc Pritzker, Thenappan Thenappan
Pulmonary hypertension (PH) complicating chronic obstructive pulmonary disease (COPD-PH) and interstitial lung disease (ILD-PH) (World Health Organization [WHO] Group III PH) increases medical costs and reduces survival. Despite limited data, many clinicians are using pulmonary arterial hypertension (PAH)-specific therapy to treat WHO Group III PH patients. To further investigate the utility of PAH-specific therapy in WHO Group III PH, we performed a systematic review and meta-analysis. Relevant studies from January 2000 through May 2016 were identified in the MEDLINE, EMBASE, and COCHRANE electronic databases and www...
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28668356/frequency-of-exacerbations-in-patients-with-chronic-obstructive-pulmonary-disease-an-analysis-of-the-spiromics-cohort
#10
MeiLan K Han, Pedro M Quibrera, Elizabeth E Carretta, R Graham Barr, Eugene R Bleecker, Russell P Bowler, Christopher B Cooper, Alejandro Comellas, David J Couper, Jeffrey L Curtis, Gerard Criner, Mark T Dransfield, Nadia N Hansel, Eric A Hoffman, Richard E Kanner, Jerry A Krishnan, Carlos H Martinez, Cheryl B Pirozzi, Wanda K O'Neal, Stephen Rennard, Donald P Tashkin, Jadwiga A Wedzicha, Prescott Woodruff, Robert Paine, Fernando J Martinez
BACKGROUND: Present treatment strategies to stratify exacerbation risk in patients with chronic obstructive pulmonary disease (COPD) rely on a history of two or more events in the previous year. We aimed to understand year to year variability in exacerbations and factors associated with consistent exacerbations over time. METHODS: In this longitudinal, prospective analysis of exacerbations in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) cohort, we analysed patients aged 40-80 years with COPD for whom 3 years of prospective data were available, identified through various means including care at academic and non-academic medical centres, word of mouth, and existing patient registries...
June 28, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28657170/the-past-decade-in-bench-research-into-pulmonary-infectious-diseases-what-do-clinicians-need-to-know
#11
REVIEW
Simon Finch, Holly R Keir, Alison J Dicker, James D Chalmers
Respiratory infections are primarily treated with antibiotics, drugs that are mostly inexpensive and have been widely available since the 1940s and 1950s. Nevertheless, despite antibiotics, the burden of disease in pneumonia, bronchiectasis, cystic fibrosis, COPD and rare respiratory infections remains exceptionally high. There is an urgent need for translational studies to develop new treatments or new biomarkers to improve outcomes in these conditions. The 'translational gaps' between bench science and clinical practice are particularly challenging in respiratory infections...
June 28, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28656664/poor-adherence-to-chronic-obstructive-pulmonary-disease-medications-in-primary-care-role-of-age-disease-burden-and-polypharmacy
#12
Davide L Vetrano, Elisa Bianchini, Graziano Onder, Iacopo Cricelli, Claudio Cricelli, Roberto Bernabei, Germano Bettoncelli, Francesco Lapi
AIM: The aim of the present study was to assess the occurrence and determinants of poor adherence to pharmacological treatment in a cohort of primary care patients with chronic obstructive pulmonary disease (COPD), paying special attention to the role of age, comorbidity and polypharmacy. METHODS: We identified a cohort of COPD patients using the primary care Italian Health Search - IMS Longitudinal Patient Database. We assessed 1-year adherence to COPD maintenance pharmacotherapy (encompassing inhaled corticosteroids, long-acting beta agonists and long-acting anticholinergics)...
June 28, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28652720/development-of-a-training-program-to-support-health-care-professionals-to-deliver-the-space-for-copd-self-management-program
#13
Claire Blackmore, Vicki L Johnson-Warrington, Johanna Ea Williams, Lindsay D Apps, Hannah Ml Young, Claire LA Bourne, Sally J Singh
BACKGROUND: With the growing burden of COPD and associated morbidity and mortality, a need for self-management has been identified. The Self-management Programme of Activity, Coping and Education for Chronic Obstructive Pulmonary Disease (SPACE for COPD) manual was developed to support self-management in COPD patients. Currently, there is no literature available regarding health care professionals' training needs when supporting patients with COPD on self-management. AIM: This study sought to identify these needs to inform, design and develop a training program for health care professionals being trained to deliver a self-management program in COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28652718/an-analysis-of-the-economic-and-patient-outcome-impact-of-an-integrated-copd-service-in-east-london
#14
Anna Garner, Matthew Hodson, Georgios Ketsetzis, Laurence Pulle, Janelle Yorke, Angshu Bhowmik
Exacerbations of COPD carry a huge burden of morbidity and a significant economic impact. It has been shown that home care may be useful for exacerbations of COPD. This article presents a review of an integrated COPD service in east London. Hospital Episode Statistics, Public Health Mortality Files and clinical data were used to analyze differences in health care usage and COPD patient outcomes, including COPD assessment test (CAT) scores for a subsample, before and after the introduction of the integrated service...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28636425/ats-nhlbi-asthma-copd-overlap-aco-workshop-report
#15
Prescott G Woodruff, Maarten van den Berge, Richard C Boucher, Christopher Brightling, Esteban G Burchard, Stephanie A Christenson, MeiLan K Han, Michael J Holtzman, Monica Kraft, David A Lynch, Fernando D Martinez, Helen K Reddel, Don D Sin, George R Washko, Sally E Wenzel, Antonello Punturieri, Michelle M Freemer, Robert A Wise
Asthma and COPD are highly prevalent chronic obstructive lung diseases with an associated high burden of disease. Asthma, which is often allergic in origin, frequently begins in infancy or childhood with variable airflow obstruction and intermittent wheezing, cough, and dyspnea. Patients with COPD, in contrast, are usually current or former smokers who present after the age of 40 years with symptoms (often persistent), including dyspnea and a productive cough. Based on age and smoking history, it is often easy to distinguish between asthma and COPD...
June 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28626506/impact-of-nonadherence-to-inhaled-corticosteroid-laba-therapy-on-copd-exacerbation-rates-and-healthcare-costs-in-a-commercially-insured-us-population
#16
Jill R Davis, Bingcao Wu, David M Kern, Ozgur Tunceli, Kathleen M Fox, John Horton, Randall F Legg, Frank Trudo
BACKGROUND: Evidence of poor patient adherence to medications for chronic obstructive pulmonary disease (COPD) is well-documented, but its impact on disease exacerbation rates and associated healthcare costs remains unclear. OBJECTIVE: To assess the association between adherence levels to different inhaled corticosteroid/long-acting ß2-adrenergic agonist (LABA) and COPD exacerbation rates and costs in a commercially insured population. METHODS: In this observational cohort study, patients with COPD (aged ≥40 years) who were treatment-naïve to inhaled corticosteroid/LABA and were initiating budesonide plus formoterol or fluticasone plus salmeterol between March 1, 2009, and January 31, 2014, were identified in a national representative claims database and were followed for up to 12 months...
April 2017: American Health & Drug Benefits
https://www.readbyqxmd.com/read/28617814/risk-of-pneumonia-in-obstructive-lung-disease-a-real-life-study-comparing-extra-fine-and-fine-particle-inhaled-corticosteroids
#17
Samatha Sonnappa, Richard Martin, Elliot Israel, Dirkje Postma, Wim van Aalderen, Annie Burden, Omar S Usmani, David B Price
BACKGROUND: Regular use of inhaled corticosteroids (ICS) in patients with obstructive lung diseases has been associated with a higher risk of pneumonia, particularly in COPD. The risk of pneumonia has not been previously evaluated in relation to ICS particle size and dose used. METHODS: Historical cohort, UK database study of 23,013 patients with obstructive lung disease aged 12-80 years prescribed extra-fine or fine-particle ICS. The endpoints assessed during the outcome year were diagnosis of pneumonia, acute exacerbations and acute respiratory events in relation to ICS dose...
2017: PloS One
https://www.readbyqxmd.com/read/28615937/patient-perceived-treatment-burden-of-chronic-obstructive-pulmonary-disease
#18
Nathan Harb, Juliet M Foster, Claudia C Dobler
BACKGROUND: While chronic morbidity and mortality from COPD is well documented, little is known about the treatment burden faced by patients with COPD. SUBJECTS AND METHODS: Patients with severe airflow obstruction (forced expiratory volume in 1 second [FEV1] <50% predicted) representing different age-groups, sex, and number of comorbidities participated in a semistructured interview. Interviews were conducted until thematic saturation was reached. Interviews were recorded, transcribed, and analyzed thematically using an established treatment-burden framework...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28610666/informal-caregiving-in-copd-a-systematic-review-of-instruments-and-their-measurement-properties
#19
REVIEW
Joana Cruz, Alda Marques, Ana Machado, Sachi O'Hoski, Roger Goldstein, Dina Brooks
BACKGROUND: Increasing symptoms and activity restriction associated with COPD progression greatly impact on the lives of their informal caregivers, who play a vital role in maintaining their health. An understanding of this impact is important for clinicians to support caregivers and maintain a viable patient environment at home. This systematic review aimed to identify the instruments commonly used to assess informal caregiving in COPD and describe their measurement properties in this population...
July 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28605262/chronic-obstructive-pulmonary-disease-from-injury-to-genomic-stability
#20
Luiz Philippe da Silva Sergio, Flavia de Paoli, Andre Luiz Mencalha, Adenilson de Souza da Fonseca
Chronic obstructive pulmonary disease (COPD) is the fourth cause of death in the world and it is currently presenting a major global public health challenge, causing premature death from pathophysiological complications and rising economic and social burdens. COPD develops from a combination of factors following exposure to pollutants and cigarette smoke, presenting a combination of both emphysema and chronic obstructive bronchitis, which causes lung airflow limitations that are not fully reversible by bronchodilators...
June 12, 2017: COPD
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