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https://www.readbyqxmd.com/read/29777660/chronic-obstructive-pulmonary-disease-exacerbations-a-need-for-action
#1
Antonio Anzueto, Marc Miravitlles
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality, with exacerbations contributing strongly to the overall severity and burden of disease at the individual level. Many patients with COPD are managed predominantly in the primary care setting; therefore, primary care physicians (PCPs) must have awareness and understanding of the causes, effects, and management of exacerbations in COPD. This review offers practical information regarding how exacerbations are defined in the treatment setting, pathogenic and environmental causes, options for exacerbation treatment and prevention, and suggestions for improving care in the clinic...
May 16, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29774778/an-overview-of-glycopyrrolate-eflow%C3%A2-cs-in-copd
#2
Edward Kerwin, Gary T Ferguson
COPD is highly prevalent in the US and globally, requiring new treatment strategies due to the high disease burden and increase in the aging population. Here, we profile the newly FDA-approved LONHALA MAGNAIR (glycopyrrolate [GLY]/eFlow® Closed System [CS]; 25 mcg twice daily), a nebulized long-acting muscarinic antagonist (LAMA) for the long-term maintenance treatment of COPD, including chronic bronchitis and/or emphysema. Areas covered: An overview of COPD and the treatment landscape, focusing on GLY/eFlow CS, is reported by reviewing the published literature pertinent to the drug/device combination...
May 18, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29769489/pattern-of-disease-among-patients-attending-cardiology-outpatient-department-of-a-private-hospital-of-mymensingh-bangladesh
#3
G K Paul, B Sen, M K Khan, T K Bhowmik, T A Khan, A K Roy
Epidemiologic transition is taking place in every part of the world. Cardiovascular diseases became the most common cause of death accounting for 30% of deaths worldwide, with 80% of the burden now occurring in developing countries. The objective of the study was to assess the Pattern of disease among patients attending Cardiology outpatient department of a private hospital. The cross sectional descriptive type of observational study was conducted among 550 patients attending Cardiology outpatient department (COPD) of Sodesh Hospital, Mymensingh, Bangladesh from March 2016 to June 2016...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29767774/common-and-rare-variants-genetic-association-analysis-of-cigarettes-per-day-among-ever-smokers-in-copd-cases-and-controls
#4
Sharon M Lutz, Brittni Frederiksen, Ferdouse Begum, Merry-Lynn McDonald, Michael H Cho, Brian Hobbs, Margaret M Parker, Dawn L DeMeo, Craig P Hersh, Marissa Eringher, Kendra Young, Lai Jiang, Marilyn G Foreman, Greg L Kinney, Barry J Make, David A Lomas, Per Bakke, Amund Gulsvik, James D Crapo, Edwin K Silverman, Terri H Beaty, John E Hokanson
Introduction: Cigarette smoking is a major environmental risk factor for many diseases, including chronic obstructive pulmonary disease (COPD). There are shared genetic influences on cigarette smoking and COPD. Genetic risk factors for cigarette smoking in cohorts enriched for COPD are largely unknown. Methods: We performed genome-wide association analyses for average cigarettes per day (CPD) across the COPDGene Non-Hispanic White (NHW) (n=6,659) and African American (AA) (n=3,260), GenKOLS (n=1,671), and ECLIPSE (n=1,942) cohorts...
May 15, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29755807/assessing-the-prevalence-and-incidence-of-asthma-and-chronic-obstructive-pulmonary-disease-in-the-eastern-mediterranean-region
#5
Mohammadreza Masjedi, Elaheh Ainy, Faried Zayeri, Rogayeh Paydar
OBJECTIVES: This study conducted in 2016 aimed to assess the prevalence and incidence of asthma and chronic obstructive pulmonary disease (COPD) in the Eastern Mediterranean Region (EMR). MATERIAL AND METHODS: A meta-analysis to evaluate the published research relating to asthma and COPD was conducted using data from 23 EMR Office (EMRO) countries and searching using the web of science, PubMed, SciVerse Scopus, Google scholar, and MEDLINE databases. The keywords entered were all EMRO countries (Afghanistan, Bahrain, Djibouti, Egypt, Islamic republic Iran, Iraq, Jordan, Kuwait, Lebanon, Libyan Arab Jamahiriya, Morocco, Oman, Pakistan, Palestine, Qatar, Saudi Arab, Somalia, Sudan, Syrian Arab Republic, Tunisia, the United Arab Emirates, Yemen republic, and Cyprus) and asthma OR chronic obstructive pulmonary disease (COPD) OR (chronic bronchitis)...
April 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29752708/coexistence-of-chronic-bronchitis-in-chronic-obstructive-lung-disease
#6
Filip Mejza, Paweł Nastałek, Agnieszka Mastalerz-Migas, Zbigniew Doniec, Wojciech Skucha
The incidence of chronic obstructive pulmonary disease (COPD) is on the rise worldwide. Chronic bronchitis is a frequent accompaniment of COPD, which increases the burden of COPD in affected individuals. The aim of this study was to characterize the phenotype of chronic bronchitis in COPD patients. The study was based on the survey data retrospectively retrieved from the Action Health-Lung Cancer Prophylaxis and Health Care Improvement screening program that concerned all the inhabitants, aged over 40, of the Proszowice administrative region situated in the Lesser Poland Voivodeship in southern Poland...
May 12, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29742472/impact-of-postherpetic-neuralgia-a-six-year-population-based-analysis-on-people-aged-50-years-or-older-%C3%A2-%C3%A2-%C3%A2
#7
Cintia Muñoz-Quiles, Mónica López-Lacort, Alejandro Orrico-Sánchez, Javier Díez-Domingo
OBJECTIVES: To estimate the incidence and burden of postherpetic neuralgia (PHN) and to investigate risk factors for PHN in the Valencia Region of Spain. METHODS: Data were extracted from population and healthcare databases from the Valencia Region (2009-2014). Herpes zoster (HZ) and PHN were defined using ICD-9 codes and drug prescriptions in people aged ≥ 50 years. The risk of HZ patients for developing PHN and potential risk factors (diabetes mellitus, COPD and heart failure) were investigated...
May 6, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29738276/psychosocial-risk-factors-and-asthma-among-adults-in-puerto-rico
#8
Yueh-Ying Han, Erick Forno, Glorisa Canino, Juan C Celedón
OBJECTIVE: Asthma and psychosocial stressors are common among Puerto Rican adults living in the United States. We estimated the prevalence of current asthma, and examined potential psychosocial risk factors and current asthma, among adults in Puerto Rico. METHODS: Cross-sectional study of 3,049 Puerto Ricans aged 18-64 years living in Puerto Rico between May 2014 and June 2016. A structured interview was conducted to obtain information on demographics, lifestyles, mental disorders, and respiratory health...
May 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29731624/symptomatic-burden-of-copd-for-patients-receiving-dual-or-triple-therapy
#9
Stephanie Chen, Mark Small, Leandro Lindner, Xiao Xu
Background: COPD is associated with a large disease burden. The use of dual (two maintenance treatments) and triple (combination of any three treatments) therapy has shown efficacy for symptom relief; however, some patients with COPD remain symptomatic despite these therapies. This study assessed the scope and magnitude of the symptomatic burden for patients with COPD receiving dual or triple therapy. Patients and methods: Cross-sectional data from three Adelphi COPD surveys (2013-2016) conducted in the USA, Europe, Japan, and China were analyzed for patients with COPD and forced expiratory volume in 1 second ≤65% receiving dual or triple therapy for ≥3 months...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29731623/disease-burden-of-copd-in-china-a-systematic-review
#10
REVIEW
Bifan Zhu, Yanfang Wang, Jian Ming, Wen Chen, Luying Zhang
Chronic obstructive pulmonary disease (COPD) is one of the main contributors to the global burden of disease. The aim of this systematic review was to quantify the disease burden of COPD in China and to determine the risk factors of the disease. The number of studies included in the review was 47 with an average quality assessment score of 7.70 out of 10. Reported COPD prevalence varied between 1.20% and 8.87% in different provinces/cities across China. The prevalence rate of COPD was higher among men (7.76%) than women (4...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29719384/influence-of-deprivation-on-health-care-use-health-care-costs-and-mortality-in-copd
#11
Peter F Collins, Rebecca J Stratton, Ramesh J Kurukulaaratchy, Marinos Elia
Background and aim: Deprivation is associated with the incidence of COPD, but its independent impact on clinical outcomes is still relatively unknown. This study aimed to explore the influence of deprivation on health care use, costs, and survival. Methods: A total of 424 outpatients with COPD were assessed for deprivation across two hospitals. The English Index of Multiple Deprivation (IMD) was used to establish a deprivation score for each patient. The relationship between deprivation and 1-year health care use, costs, and mortality was examined, controlling for potential confounding variables (age, malnutrition risk, COPD severity, and smoking status)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29715564/risk-factors-for-return-to-the-emergency-department-for-asthma-a-population-based-study
#12
Teresa To, Jingqin Zhu, Kandace Ryckman, Andrea Gershon
BACKGROUND: A substantial proportion of asthma patients return after being discharged from the emergency department (ED). Given the high economic burden of acute care claims, and the impact on productivity and quality of life, better understanding risk factors for ED return is of interest. OBJECTIVE: To quantify the rate and determine factors associated with return to the ED for asthma within 1-year of an asthma ED visit. METHODS: Individuals aged 5 to 99 years living in Ontario, Canada with an asthma ED visit in 2008-2014 were included...
April 28, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29715272/one-year-survival-rate-and-healthcare-costs-after-cardiac-arrest-in-taiwan-2006-2012
#13
Yi-Ming Weng, Chip-Jin Ng, Chen-June Seak, Cheng-Yu Chien, Kuan-Fu Chen, Jr-Rung Lin, Chee-Jen Chang
OBJECTIVES: The annual increase in costs and the quality of life of survivors of cardiac arrest are major concerns. This study used National Health Insurance Research Database (NHIRD) of Taiwan to evaluate the 1-year survival rate and the annual healthcare costs of survivors after cardiac arrest. METHODS: This retrospective, fixed-cohort study conducted from 2006 to 2012, involved 2 million individuals randomly selected from the NHIRD of Taiwan. Adult patients at least 18 years old who were diagnosed with cardiac arrest were enrolled...
2018: PloS One
https://www.readbyqxmd.com/read/29713158/heterogeneity-of-asthma-and-copd-overlap
#14
Min-Hye Kim, Chin Kook Rhee, Kyungjoo Kim, Sang Hyun Kim, Jung Yeon Lee, Yee Hyung Kim, Kwang Ha Yoo, Young-Joo Cho, Ki-Suck Jung, Jin Hwa Lee
Background: Asthma and COPD are heterogeneous diseases. Patients with both disease features (asthma-COPD overlap [ACO]) are common. However, clinical characteristics and socio-economic burden of ACO are still controversial. The aim of this study was to identify the heterogeneity of ACO and to find out the subtypes with clinical impact among ACO subtypes. Methods: In the Korean National Health and Nutrition Examination Survey (KNHANES) conducted between 2007 and 2012, subjects who were ≥40 years and had prebronchodilator FEV1 /FVC <0...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29705784/coexisting-heart-failure-and-chronic-obstructive-pulmonary-disease-report-of-two-cases-treated-with-indacaterol-glycopyrronium
#15
Eugenio Roberto Cosentino, Daniela Degli Esposti, Rinaldo Miceli, Crescenzio Bentivenga, Matteo Landolfo, Ilaria Ricci Iamino, Luca Spinardi, Gianluigi Magri, Claudio Borghi
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide, and it is associated with a high economic burden. Heart failure shares some general symptoms with COPD; thus, diagnosing COPD is difficult in subjects with a history of heart failure, and spi-rometry is mandatory for confirmation. Moreover, COPD is a highly prevalent comorbidity negatively impacting the outcome of heart failure patients. We document here the treatment with indacaterol/glycopyrronium in 2 patients with concomitant COPD and heart failure...
2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29701390/ascending-aorta-aneurysms-in-octogenarians
#16
Jorge Pinheiro Santos, Álvaro Laranjeira, António Cruz Tomás, Daniela Varela-Afonso, José Fragata
INTRODUCTION: Older age is often regarded as a relative contraindication for open surgery for aortic aneurysms. These individuals often have a greater comorbidity burden that predispose them for development of postoperative complications. The aim of our study is to evaluate the surgical outcomes of selected octogenarians after open aortic surgery. METHODS: We performed a retrospective observational study. We collected data from patients operated on by our team between January of 2012 to September of 2017...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29697272/mortality-related-to-chronic-obstructive-pulmonary-disease-and-co-morbidities-in-the-united-states-a-multiple-causes-of-death-analysis
#17
Jennifer Obi, Alem Mehari, Richard Gillum
Chronic obstructive pulmonary disease (COPD) mortality based on the underlying cause of death (UCOD) underestimates disease burden. We aimed to determine the current COPD mortality rate, trends and the distribution of co-morbidities using United States (US) multiple-cause of death (MCOD) records. All 38,905,575 death certificates of decedents aged ≥45 years in the United States were analyzed for 1999-2015. COPD was defined by ICD-10 codes J40-J44 and J47 based either on the UCOD or up to 20 contributing causes coded...
April 26, 2018: COPD
https://www.readbyqxmd.com/read/29695902/randomized-double-blind-placebo-controlled-trial-to-assess-the-efficacy-and-safety-of-three-doses-of-co-suspension-delivery-technology-glycopyrronium-mdi-in-japanese-patients-with-moderate-to-severe-copd
#18
Yasushi Fukushima, Yuji Nakatani, Yumiko Ide, Hisakuni Sekino, Earl St Rose, Shahid Siddiqui, Andrea Maes, Colin Reisner
Purpose: Due to the burden of COPD in Japan, new pharmacologic treatments are needed to meet patient requirements. This study assessed the efficacy and safety of glycopyrronium (GP) delivered via metered dose inhaler (MDI) in Japanese patients with moderate-to-severe COPD. Methods: This Phase IIb, multicenter, randomized, double-blind, 7-day, crossover study compared GP MDI 28.8, 14.4, and 7.2 μg with placebo MDI (all administered as two inhalations, twice daily)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29695236/associations-between-comorbidities-their-treatment-and-survival-in-patients-with-interstitial-lung-diseases-a-claims-data-analysis
#19
Larissa Schwarzkopf, Sabine Witt, Julia Waelscher, Markus Polke, Michael Kreuter
BACKGROUND: Interstitial lung diseases (ILDs) are associated with a high burden of disease. However, data on the prognostic impact of comorbidities and comorbidity-related pharmaceutical treatments in patients with various ILDs remain sparse. METHODS: Using longitudinal claims data from a German Statutory Health Insurance Fund, we assessed comorbidity in ILD subtypes and associated drug treatments. Baseline comorbidity was assessed via the Elixhauser Comorbidity Index that was amended by ILD-relevant conditions...
April 25, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29695056/burden-of-serious-fungal-infections-in-argentina
#20
Fernando O Riera, Juan P Caeiro, David W Denning
The number of fungal infections at any given time in Argentina is not known. Here we estimate the burden of serious fungal infections in Argentina for the first time. Specific population statistics were searched from multiple sources, local literature was identified, and estimates made. Some additional data were sourced from the Ministry of Health, the Global Initiative for Asthma (GINA) program, and national haematology and transplant societies. Argentina has a population of 43.8 million, with 25% of this total being children under 15 years...
April 24, 2018: Journal of Fungi (Basel, Switzerland)
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