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Copd burden

Hang Qiu, Kun Tan, Feiyu Long, Liya Wang, Haiyan Yu, Ren Deng, Hu Long, Yanlong Zhang, Jingping Pan
Evidence on the burden of chronic obstructive pulmonary disease (COPD) morbidity attributable to the interaction between ambient air pollution and temperature has been limited. This study aimed to examine the modification effect of temperature on the association of ambient air pollutants (including particulate matter (PM) with aerodynamic diameter <10 μm (PM10 ) and <2.5 μm (PM2.5 ), nitrogen dioxide (NO₂), sulfur dioxide (SO₂), carbon monoxide (CO) and ozone (O₃)) with risk of hospital admissions (HAs) for COPD, as well as the associated morbidity burden in urban areas of Chengdu, China, from 2015 to 2016...
March 11, 2018: International Journal of Environmental Research and Public Health
Jinsong Zhang, Anastasia Miller, Yongxia Li, Qinqin Lan, Ning Zhang, Yanling Chai, Bing Hai
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a serious chronic condition with a global impact. Symptoms of COPD include progressive dyspnea, breathlessness, cough, and sputum production, which have a considerable impact on the lives of patients. In addition to the human cost of living with COPD and the resulting death, COPD entails a huge economic burden on the Chinese population, with patients spending up to one-third of the average family income on COPD management in some regions is clinically beneficial to adopt preventable measures via prudent COPD care utilization, monetary costs, and hospitalizations...
March 7, 2018: Tuberculosis and Respiratory Diseases
Liza Cragg, Siân Williams, Thys van der Molen, Mike Thomas, Jaime Correia de Sousa, Niels H Chavannes
There is growing awareness amongst healthcare planners, providers and researchers of the need to make better use of routinely collected health data by translating it into actionable information that improves efficiency of healthcare and patient outcomes. There is also increased acceptance of the importance of real world research that recruits patients representative of primary care populations and evaluates interventions realistically delivered by primary care professionals. The UNLOCK Group is an international collaboration of primary care researchers and practitioners from 15 countries...
March 8, 2018: NPJ Primary Care Respiratory Medicine
Thermite Mara, Long-Teng Ma, Shuo Wang, Ling Wang, Fan Yang, Jia-Hui Song, Yi-Chun Cao, Jian-Hua Yin, Guang-Wen Cao
BACKGROUND: Chronic diseases cause a tremendous burden to the military medical system. However, the prevalence rates of major chronic diseases among military officers remain unclear in China. METHODS: China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database for Chinese Technical Periodicals (VIP), PubMed and Web of Science were searched for studies (from 2000 to 2016) concerning 6 major chronic diseases: hypertension, hyperlipidemia, diabetes mellitus, heart diseases, cerebrovascular diseases, and chronic obstructive pulmonary diseases (COPD) in Chinese military officers following strict inclusion and exclusion criteria...
January 30, 2018: Military Medical Research
Joel T Zelt, Joshua H Jones, Daniel M Hirai, Trevor J King, Danilo C Berton, Kyra E Pyke, Denis E O'Donnell, J Alberto Neder
BACKGROUND: Cardiovascular diseases play a major role in morbidity and mortality in the earlier stages of COPD. We hypothesized that systemic vascular dysfunction would be present even in patients who are currently considered at "low-risk" for negative cardiovascular outcomes, i.e., those with largely preserved FEV1 , few exacerbations and only mild burden of respiratory symptoms (GOLD spirometric grade 1, clinical group A). METHODS: 16 patients (FEV1  = 86 ± 13%) and 16 age- and gender-matched controls underwent measurements of: a) central arterial stiffness by pulse wave velocity, b) brachial flow-mediated dilation and c) forearm muscle oxygenation by near-infrared spectroscopy...
March 2018: Respiratory Medicine
Karin Lisspers, Christer Janson, Kjell Larsson, Gunnar Johansson, Gunilla Telg, Marcus Thuresson, Björn Ställberg
BACKGROUND: Asthma is often associated with other diseases. To identify and manage comorbidities is important, as these conditions may increase the disease burden. OBJECTIVE: To describe the prevalence of comorbidities, disease burden and mortality across age groups in a large Swedish primary care real-life asthma population. METHODS: Observational cohort study of asthma patients, all ages, identified from electronic medical records by ICD-10-CM code, data from 36 primary care centers...
March 2018: Respiratory Medicine
Mihai Mareș, Valentina Ruxandra Moroti-Constantinescu, David W Denning
OBJECTIVE: To estimate for the first time the burden of fungal infections in Romania. METHODS: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations, and published annual reports on local epidemiology were used in the present study. When no data were available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters...
March 1, 2018: Journal of Fungi (Basel, Switzerland)
Jelena Ostojić, Hrvoje Pintarić
Chronic obstructive pulmonary disease (COPD) and heart failure (HF) both are global epidemics with substantial burden on morbidity and mortality. They present major challenges to healthcare providers and often coexsist. Multiple interactions exist between these conditions. COPD is often responsible for delayed diagnosis of HF and vice versa, since both conditions have similar symptoms such as dyspnea and poor exercise tolerance based on the skeletal myopathic response rather than the primary organ failure. Patients with COPD also have an increased risk of developing HF and higher hospitalization and death rates compared with HF patients without COPD...
June 2017: Acta Clinica Croatica
Olorunfemi A Oshagbemi, Andrea M Burden, Kimberly N Shudofsky, Johanna H M Driessen, Peter Vestergaard, Andreas Krings, Frits Franssen, Joop van den Bergh, Frank de Vries
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is characterised by persistent airflow obstruction and respiratory symptoms. While short course systemic GCs are prescribed in patients with acute COPD exacerbations, little is known of the risk of fractures with intermittent exposure to high-dose GC and the effect of proxies of disease severity. METHODS: A case-control study was conducted using the Danish National Hospital Discharge Registry (NHDR) between January 1996 to December 2011...
February 17, 2018: Bone
Philippe Lachapelle, Meina Li, Jo Douglass, Alastair Stewart
The transforming growth factor (TGF)-β cytokines play a central role in development and progression of chronic respiratory diseases. TGF-β overexpression in chronic inflammation, remodeling, fibrotic process and susceptibility to viral infection is established in the most prevalent chronic respiratory diseases including asthma, COPD, lung cancer and idiopathic pulmonary fibrosis. Despite the overwhelming burden of respiratory diseases in the world, new pharmacological therapies have been limited in impact...
February 17, 2018: Pharmacology & Therapeutics
Tristan Bonnevie, Francis-Edouard Gravier, David Debeaumont, Catherine Viacroze, Jean-François Muir, Antoine Cuvelier, Marie Netchitaïlo, Anne Laure Roy, Jean Quieffin, Marie-Hélène Marques, Clément Médrinal, Johan Dupuis, Catherine Tardif
OBJECTIVE: To assess the additional effect of a home-based neuro muscular electrical stimulation (NMES) program as an add-on to pulmonary rehabilitation (PR), on functional capacity in subjects with chronic obstructive pulmonary disease (COPD). DESIGN: Single-blind, multicenter randomized trial. SETTING: Three PR centers. PARTICIPANTS: Subjects with severe to very severe COPD referred for PR (n=73; median FEV1, 1 (0...
February 16, 2018: Archives of Physical Medicine and Rehabilitation
Tara Ballav Adhikari, Dinesh Neupane, Per Kallestrup
Background: COPD is a globally significant public health problem and is the second leading cause of mortality. This study presents the health burden of COPD in Nepal using the Global Burden of Disease (GBD) study 2016 dataset. Methods: This study used the data from the GBD repository presenting morbidity and mortality attributed to COPD, by sex and age. In GBD 2016, due to a lack of the primary source of data in Nepal, estimations on morbidity and mortality of COPD were based on its predictive covariates...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Guy B Marks
No abstract text is available yet for this article.
February 14, 2018: Thorax
Chloe I Bloom, Bhavan Slaich, Daniel R Morales, Liam Smeeth, Patrick Stone, Jennifer K Quint
Mortality and symptom burden from chronic obstructive pulmonary disease (COPD) and lung cancer are similar but there is thought to be an inequality in palliative care support (PCS) between diseases. This nationally representative study assessed PCS for COPD patients within primary care in the UK.This was a cohort study using electronic healthcare records (2004-2015). Factors associated with receiving PCS were assessed using logistic regression for the whole cohort and deceased patients.There were 92 365 eligible COPD patients, of which 26 135 died...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Michael G Crooks, Timothy Brown, Alyn H Morice
Chronic obstructive pulmonary disease is predicted to become the 4th leading cause of death worldwide by 2030. The natural history of the disease includes progressive symptoms punctuated by acute exacerbations during which symptoms rapidly deteriorate. The resulting disability places significant burden on health and social care systems. Cough is the second most common symptom reported by COPD patients, is a source of significant distress and is associated with adverse outcomes. We discuss the importance of cough in COPD, its mechanism and the relationship between cough and COPD exacerbations...
February 10, 2018: Respiratory Physiology & Neurobiology
A Dudina, S Lane, M Butler, M-T Cooney, I Graham
Background: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic obstructive pulmonary disease (COPD) and such patients tend to carry a heavy burden of risk factors for CVD. There is little information on the documentation and management of CVD risk factors in COPD patients. Aim: To audit the recording and management of CVD risk factors in 200 COPD patients attending the respiratory out-patient clinics at two University teaching hospitals...
February 8, 2018: QJM: Monthly Journal of the Association of Physicians
B W Allwood, R Gillespie, M Bateman, H Olckers, L Taborda-Barata, G L Calligaro, R Van Zyl-Smit, C B Cooper, N Beyers, E D Bateman
BACKGROUND: A community-based prevalence survey performed in two suburbs in Cape Town, South Africa (SA), in 2005, using the international Burden of Obstructive Lung Disease (BOLD) method, confirmed a prevalence of chronic airflow obstruction (CAO) in 23.1% of adults aged &gt;40 years. OBJECTIVES: To study the clinical course and prognosis over 5 years of patients with CAO identified in the 2005 survey. METHODS: Patients with CAO in 2005 were invited to participate...
February 1, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Hualiang Lin, Zhengmin Min Qian, Yanfei Guo, Yang Zheng, Siqi Ai, Jian Hang, Xiaojie Wang, Lingli Zhang, Tao Liu, Weijie Guan, Xing Li, Jianpeng Xiao, Weilin Zeng, Hong Xian, Steven W Howard, Wenjun Ma, Fan Wu
BACKGROUND: The linkage between ambient fine particle pollution (PM2.5 ) and chronic obstructive pulmonary disease (COPD) and the attributable risk remained largely unknown. This study determined the cross-sectional association between ambient PM2.5 and prevalence of COPD among adults ≥50 years of age. METHODS: We surveyed 29,290 participants aged 50 years and above in this study. The annual average concentrations of PM2.5 derived from satellite data were used as the exposure indicator...
February 5, 2018: Environment International
Andrea S Gershon, Deva Thiruchelvam, Kenneth R Chapman, Shawn D Aaron, Matthew B Stanbrook, Jean Bourbeau, Wan Tan, Teresa To
BACKGROUND: Misdiagnosis of chronic obstructive pulmonary disease (COPD) is common. We aimed to quantify the health services burden of undiagnosed and overdiagnosed COPD in a real world, North American population. METHODS: A population-based cohort study was conducted. Presence of COPD using spirometry was ascertained in randomly selected adults age 40 or older from Ontario, Canada who participated in the Canadian Obstructive Lung Disease study. Presence of physician diagnosed COPD was ascertained for the same people using linked health administrative data...
February 6, 2018: Chest
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