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https://www.readbyqxmd.com/read/28431503/understanding-the-impact-of-symptoms-on-the-burden-of-copd
#1
REVIEW
Marc Miravitlles, Anna Ribera
Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on individuals with the disease, which can include a range of symptoms (breathlessness, cough, sputum production, wheeze, chest tightness) of varying severities. We present an overview of the biomedical literature describing reported relationships between COPD symptoms and disease burden in terms of quality of life, health status, daily activities, physical activity, sleep, comorbid anxiety, and depression, as well as risk of exacerbations and disease prognosis...
April 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28425194/unlocking-the-limitations-living-with-chronic-obstructive-pulmonary-disease-and-receiving-care-through-telemedicine-a-phenomenological-study
#2
Tina Lien Barken, Elin Thygesen, Ulrika Söderhamn
AIMS AND OBJECTIVES: The aim of this study was to describe the lived experiences of quality of life among a group of patients living with chronic obstructive pulmonary disease (COPD) who were included in a telemedical intervention after hospitalization for disease exacerbation. BACKGROUND: Patients with COPD have high symptom burden, poor control of symptoms, and a need for greater requirements in care. Telemedicine (TM) can provide benefits for patients with COPD by improving self-management...
April 20, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28409741/impact-of-comorbidities-among-medicaid-enrollees-with-chronic-obstructive-pulmonary-disease-united-states-2009
#3
Gloria Westney, Marilyn G Foreman, Junjun Xu, Marshaleen Henriques King, Eric Flenaugh, George Rust
INTRODUCTION: Multimorbidity, the presence of 2 or more chronic conditions, frequently affects people with chronic obstructive pulmonary disease (COPD). Many have high-cost, highly complex conditions that have a substantial impact on state Medicaid programs. We quantified the cost of Medicaid-insured patients with COPD co-diagnosed with other chronic disorders. METHODS: We used nationally representative Medicaid claims data to analyze the impact of comorbidities (other chronic conditions) on the disease burden, emergency department (ED) use, hospitalizations, and total health care costs among 291,978 adult COPD patients...
April 13, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28399427/clinical-and-cost-effectiveness-of-nurse-led-self-management-interventions-for-patients-with-copd-in-primary-care-a-systematic-review
#4
REVIEW
Elizabeth Baker, Francis Fatoye
BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease is increasing in prevalence and constitutes a major cause of morbidity and mortality globally. As well as contributing to a significant decline in health status in many patients, this condition creates a considerable burden on healthcare providers. Self-management interventions are frequently implemented in community settings to limit the impact of chronic obstructive pulmonary disease on everyday life of individuals and to manage pressure on health systems...
March 31, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28399185/prevalence-and-risk-factors-of-airflow-limitation-in-a-mongolian-population-in-ulaanbaatar-cross-sectional-studies
#5
Motoyuki Nakao, Keiko Yamauchi, Yoko Ishihara, Hisamitsu Omori, Bandi Solongo, Dashtseren Ichinnorov
The burden of chronic obstructive pulmonary disease (COPD) is expected to increase in the coming decades. In Ulaanbaatar, Mongolia, air pollution, which has been suggested to correlate with COPD, is a growing concern. However, the COPD prevalence in Ulaanbaatar is currently unknown. This study aims to estimate the prevalence of airflow limitation and investigate the association between airflow limitation and putative risk factors in the Mongolian population. Five cross-sectional studies were carried out in Ulaanbaatar...
2017: PloS One
https://www.readbyqxmd.com/read/28397992/mucoactive-agents-for-chronic-non-cystic-fibrosis-lung-disease-a-systematic-review-and-meta-analysis
#6
REVIEW
Benjamin J Tarrant, Caitlin Le Maitre, Lorena Romero, Ranjana Steward, Brenda M Button, Bruce R Thompson, Anne E Holland
Inhaled mucoactive agents are used in respiratory disease to improve mucus properties and enhance secretion clearance. The effect of mannitol, recombinant human deoxyribonuclease/dornase alfa (rhDNase) and hypertonic saline (HS) or normal saline (NS) are not well described in chronic lung conditions other than cystic fibrosis (CF). The aim of this review was to determine the benefit and safety of inhaled mucoactive agents outside of CF. We searched Medline, Embase, CINAHL and CENTRAL for randomized controlled trials investigating the effects of mucoactive agents on lung function, adverse events (AEs), health-related quality of life (HRQOL), hospitalization, length of stay, exacerbations, sputum clearance and inflammation...
April 11, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28393718/comorbidities-and-their-impact-on-chronic-obstructive-pulmonary-disease
#7
Neşe Dursunoğlu, Nurdan Köktürk, Ayşe Baha, Ahmet Kaya Bilge, Şermin Börekçi, Fatma Çiftçi, Makbule Gezmen Karadağ, Ebru Çalık Kütükçü, Ayşın Noyan, Mehmet Polatlı, Zeynep Pınar Önen, Sevinç Sarınç, Sema Umut, Esra Uzaslan, Ayşe Kubat Üzüm, Öznur Akkoca Yıldız
Chronic obstructive pulmonary disease (COPD) is a complex disease that is associated with devastating outcomes resulting from lung involvement and several comorbidities. Comorbidities could impact on symptomology, quality of life, the complications, the management, economic burden and the mortality of the disease. The importance of comorbidities originates from their impact on the outcome of COPD. The most frequent comorbidities in COPD are cardiovascular, endocrinological, musculoskeletal, phycological disorders and lung cancer...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28388301/procalcitonin-biomarker-algorithm-reduces-antibiotic-prescriptions-duration-of-therapy-and-costs-in-chronic-obstructive-pulmonary-disease-a-comparison-in-the-netherlands-germany-and-the-united-kingdom
#8
Marloes E van der Maas, Gertjan Mantjes, Lotte M G Steuten
Antibiotics are often recommended as treatment for patients with chronic obstructive pulmonary disease (COPD) exacerbations. However, not all COPD exacerbations are caused by bacterial infections and there is consequently considerable misuse and overuse of antibiotics among patients with COPD. This poses a severe burden on healthcare resources such as increased risk of developing antibiotic resistance. The biomarker procalcitonin (PCT) displays specificity to distinguish bacterial inflammations from nonbacterial inflammations and may therefore help to rationalize antibiotic prescriptions...
April 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28382766/patients-and-families%C3%A2-realizing%C3%A2-their-future-with-chronic-obstructive-pulmonary-disease-a-qualitative-study
#9
Gudrun H Bragadottir, Bryndis S Halldorsdottir, T Soley Ingadottir, Helga Jonsdottir
AIMS AND OBJECTIVES: To gain insight into the lived experience of learning about having Chronic Obstructive Pulmonary Disease (COPD) for patients and their families. BACKGROUND: COPD often progresses for years. Adjustment to declining health is gradual and the disease may have developed considerably when health care is sought and people are diagnosed. Reaching patients at early stages is necessary to delay progression of the disease. DESIGN: Interpretive phenomenology...
April 5, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28382660/the-effects-of-threshold-inspiratory-muscle-training-in-patients-with-chronic-obstructive-pulmonary-copd-disease-a-randomized-experimental-study
#10
Han-Yu Chuang, Hsiao Yun Chang, Yueh-Yen Fang, Su-Er Guo
AIMS: To investigate the effects of threshold inspiratory muscle training (IMT) in patients with stages II through IV chronic obstructive pulmonary disease (COPD) using maximum inspiratory pressure (PImax), baseline dyspnoea index (BDI), 6-minute walk test (6MWT), and quality of life (QoL). BACKGROUND: A threshold inspiratory muscle training device provides pressure for inspiratory muscle strength, but there is limited information on the effects of threshold inspiratory muscle training starting at low pressure training...
April 5, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28366142/-comorbidities-and-their-impact-on-chronic-obstructive-pulmonary-disease
#11
Neşe Dursunoğlu, Nurdan Köktürk, Ayşe Baha, Ahmet Kaya Bilge, Şermin Börekçi, Fatma Çiftçi, Makbule Gezmen Karadağ, Ebru Çalık Kütükçü, Ayşın Noyan, Mehmet Polatlı, Zeynep Pınar Önen, Sevinç Sarınç, Sema Umut, Esra Uzaslan, Ayşe Kubat Üzüm, Öznur Akkoca Yıldız
Chronic obstructive pulmonary disease (COPD) is a complex disease that is associated with devastating outcomes resulting from lung involvement and several comorbidities. Comorbidities could impact on symptomology, quality of life, the complications, the management, economic burden and the mortality of the disease. The importance of comorbidities originates from their impact on the outcome of COPD. The most frequent comorbidities in COPD are cardiovascular, endocrinological, musculoskeletal, phycological disorders and lung cancer...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28360517/greater-dyspnea-is-associated-with-lower-health-related-quality-of-life-among-european-patients-with-copd
#12
Jean-Bernard Gruenberger, Jeffrey Vietri, Dorothy L Keininger, Donald A Mahler
OBJECTIVE: Dyspnea is a defining symptom in the classification and treatment of chronic obstructive pulmonary disease (COPD). However, the degree of variation in burden among symptomatic COPD patients and the possible correlates of burden remain unclear. This study was conducted to characterize patients in Europe currently being treated for COPD according to the level of dyspnea in terms of sociodemographics, health-related quality of life, work productivity impairment, and health care resource use assessed by patient reports...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28356728/impact-of-a-copd-comprehensive-case-management-program-on-hospital-length-of-stay-and-readmission-rates
#13
Abdulmajeed Alshabanat, Michael C Otterstatter, Don D Sin, Jeremy Road, Carmen Rempel, Jane Burns, Stephan F van Eeden, J M FitzGerald
BACKGROUND: COPD accounts for the highest rate of hospital admissions among major chronic diseases. COPD hospitalizations are associated with impaired quality of life, high health care utilization, and poor prognosis and result in an economic and a social burden that is both substantial and increasing. AIM: The aim of this study is to determine the efficacy of a comprehensive case management program (CCMP) in reducing length of stay (LOS) and risk of hospital admissions and readmissions in patients with COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28356123/epidemiology-of-chronic-obstructive-pulmonary-disease-in-the-global-hiv-infected-population-a-systematic-review-and-meta-analysis-protocol
#14
Jean Joel R Bigna, Angeladine Malaha Kenne, Serra Lem Asangbeh
BACKGROUND: Evidence suggests a relationship between human immunodeficiency virus (HIV) infection and chronic obstructive pulmonary disease (COPD). Although the high burden of COPD and the HIV disease is clearly demonstrated, to the best of our knowledge, there is a lack of summary and meta-analysis data on the epidemiology of COPD in the global HIV-infected population to date. The present protocol for a systematic review and meta-analysis intends to summarize existing data on the prevalence, incidence, and risk factors of COPD in the global HIV-infected population...
March 29, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28353374/prediction-of-poor-short-term-prognosis-and-unmet-needs-in-advanced-chronic-obstructive-pulmonary-disease-use-of-the-two-minute-walking-distance-extracted-from-a-six-minute-walk-test
#15
Han-Yee Neo, Hui-Ying Xu, Huei-Yaw Wu, Allyn Hum
OBJECTIVES: Prognostic challenges hinder the identification of patients with advanced chronic obstructive pulmonary disease (COPD) for timely palliative interventions. We postulate that a two-minute derivative (two-minute walking distance [2MWD]) of a standard six-minute walk test (6MWT) can identify frail subjects with poorer survival for early palliative intervention. The primary outcome of interest is mortality at 18 months. Secondary objectives include evaluation of the relationship between the 2MWD and ability to self-care, dyspnea-related disabilities, nutrition, forced expiratory volume in first second (FEV1), quality of life (QoL), and comorbidity burden...
March 29, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28351441/-oxygen-therapy-not-required-for-all-copd-patients
#16
L E G W Vanfleteren
Long-term oxygen therapy in patients with pronounced hypoxia is an important and life-extending therapy. Many patients have only mild hypoxia, do not experience nocturnal desaturation, or experience desaturation only during exercise. While often applied in clinical practice, the clinical relevance of oxygen therapy was not clear in these patients. A recent randomized controlled trial has now revealed no additional value for long-term oxygen therapy in subjects with mild oxygen desaturation or exercise-induced oxygen desaturation only...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28344354/hdac1-3-inhibitor-ms-275-enhances-il10-expression-in-raw264-7-macrophages-and-reduces-cigarette-smoke-induced-airway-inflammation-in-mice
#17
Niek G J Leus, Thea van den Bosch, Petra E van der Wouden, Kim Krist, Maria E Ourailidou, Nikolaos Eleftheriadis, Loes E M Kistemaker, Sophie Bos, Rutger A F Gjaltema, Solomon A Mekonnen, Rainer Bischoff, Reinoud Gosens, Hidde J Haisma, Frank J Dekker
Chronic obstructive pulmonary disease (COPD) constitutes a major health burden. Studying underlying molecular mechanisms could lead to new therapeutic targets. Macrophages are orchestrators of COPD, by releasing pro-inflammatory cytokines. This process relies on transcription factors such as NF-κB, among others. NF-κB is regulated by lysine acetylation; a post-translational modification installed by histone acetyltransferases and removed by histone deacetylases (HDACs). We hypothesized that small molecule HDAC inhibitors (HDACi) targeting class I HDACs members that can regulate NF-κB could attenuate inflammatory responses in COPD via modulation of the NF-κB signaling output...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28342778/-the-burden-of-fungal-infections-in-algeria
#18
REVIEW
M Chekiri-Talbi, D W Denning
In Algeria, superficial mycoses are very commonly diagnosed. Deep fungal infections are less often observed. Few data from Algeria are found in the literature. We report for the first time the main causes of these diseases in our country and provide burden estimates. We searched for existing data and estimated the incidence and prevalence of fungal diseases based on the population at risk and available epidemiological data. Demographic data were derived from the Service (Office) of the Statistics (ONES), World Health Organization (WHO), The Joint Nations Programme on HIV/AIDS (UNAIDS) and national published reports...
March 22, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28341500/effect-of-2-chlorhexidine-gluconate-impregnated-cloth-on-surgical-site-infections-in-vascular-surgery
#19
John Bak, Jason Le, Toshio Takayama, Angela Gibson, Sara Zerbel, Nasia Safdar, Jon Matsumura
OBJECTIVE: Surgical site infections (SSI) are a significant burden to patients and healthcare systems. This retrospective study evaluates the observed rates of SSI after our institution implemented chlorhexidine gluconate-impregnated (CHG) cloth as a preoperative antiseptic preparation in elective vascular surgery. METHODS: Between March 2011 and January 2012, we reviewed 250 patients who underwent elective vascular surgery who used the CHG cloth preoperatively...
March 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28340856/changes-in-the-prevalence-of-copd-in-korea-between-2001-and-2011-in-the-knhanes-data
#20
Ji Young Hong, Ji Ye Jung, Myung Goo Lee, Se Kyu Kim, Joon Chang, Chang Youl Lee, Young Sam Kim
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a serious public health problem. Understanding the longitudinal trend in prevalence is important for characterizing the burden of COPD and planning health services. METHODS: We analyzed the prevalence of airflow obstruction between 2001 and 2011 using data from Korean National Health and Nutritional Examination Surveys (2001, n = 2217; 2011, n = 3101). Participants >40 years of age with an FEV1/FVC <0...
April 2017: Respiratory Medicine
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