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https://www.readbyqxmd.com/read/28346581/home-based-hypnotherapy-self-exercises-vs-individual-hypnotherapy-with-a-therapist-for-treatment-of-pediatric-irritable-bowel-syndrome-functional-abdominal-pain-or-functional-abdominal-pain-syndrome-a-randomized-clinical-trial
#1
Juliette M T M Rutten, Arine M Vlieger, Carla Frankenhuis, Elvira K George, Michael Groeneweg, Obbe F Norbruis, Walther Tjon A Ten, Herbert M van Wering, Marcel G W Dijkgraaf, Maruschka P Merkus, Marc A Benninga
Importance: Individual gut-directed hypnotherapy (HT) is effective in pediatric irritable bowel syndrome (IBS) and functional abdominal pain or functional abdominal pain syndrome (FAP[S]). It is, however, unavailable to many children. Objective: To compare the effectiveness of HT by means of home-based self-exercises using a CD with that of individual HT (iHT) performed by qualified therapists. Design, Setting, and Participants: This noninferiority randomized clinical trial with a follow-up of 1 year after the end of treatment was conducted from July 15, 2011, through June 24, 2013, at 9 secondary and tertiary care centers throughout the Netherlands...
March 27, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28346516/protective-immune-responses-against-schistosoma-mansoni-infection-by-immunization-with-functionally-active-gut-derived-cysteine-peptidases-alone-and-in-combination-with-glyceraldehyde-3-phosphate-dehydrogenase
#2
Hatem Tallima, Jan Dvořák, Sahira Kareem, Marwa Abou El Dahab, Nada Abdel Aziz, John Pius Dalton, Rashika El Ridi
BACKGROUND: Schistosomiasis, a severe disease caused by parasites of the genus Schistosoma, is prevalent in 74 countries, affecting more than 250 million people, particularly children. We have previously shown that the Schistosoma mansoni gut-derived cysteine peptidase, cathepsin B1 (SmCB1), administered without adjuvant, elicits protection (>60%) against challenge infection of S. mansoni or S. haematobium in outbred, CD-1 mice. Here we compare the immunogenicity and protective potential of another gut-derived cysteine peptidase, S...
March 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28346393/choerosponins-a-and-b-two-new-cytotoxic-bridged-ring-ketones-and-the-determination-of-their-absolute-configurations
#3
Chang-Wei Li, Bing Han, Bing Cai, Cheng-Bin Cui
Bioactivity-directed fractionation of antitumor compounds from the stem barks of Choerospondias axillaries (Roxb.) Burtt et Hill (Anacardiaceae) afforded two new cytotoxic bridged-ring ketones, choerosponins A (1) and B (2), and their structures were elucidated by spectroscopic methods; their stereochemistry was determined by NOE difference experiments, CD spectra and the modified Mosher's method. Compound 1 has a rare dioxatricyclo skeleton. Flow cytometry and SRB methods were employed to evaluate the antitumor activity of the two compounds against tsFT210, HCT-15, HeLa, A2780 and MCF-7 cell lines, and both of them showed strong cytotoxicity...
March 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28346084/is-there-a-role-for-pharmacogenetics-in-the-dosing-of-fentanyl
#4
Stijn Lw Koolen, Carin Cd Van der Rijt
No abstract text is available yet for this article.
March 27, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28346071/mineral-composition-and-toxic-element-levels-of-muscle-liver-and-kidney-of-intensive-swedish-landrace-and-extensive-mangulica-pigs-from-serbia
#5
Dragica Nikolic, Jasna Djinovic-Stojanovic, Sasa Jankovic, Nikola Stanisic, Cedomir Radovic, Lato Pezo, Mila Lausevic
Mineral composition (Fe, Zn, Cu, Mn, Se, Cr, Co, Ni, Na, K, Mg, Ca) and toxic element levels (Cd, Pb, Hg, As) of soil, feed and tissue (muscle, liver and kidney) from intensive (Swedish Landrace, housed indoors, fed a known diet, 4 years) and extensive (Mangulica, free-roaming, non-specified diet, 7-8 months) pigs was determined by inductively coupled plasma mass spectrometry (ICP-MS). Controlled nutrition produced pigs with higher concentrations of most minerals (muscle: Mn, Se, K, Mg; liver: Zn, Cu, Mn, Se, Cr, Ca; kidney: Zn, Cu, Mn, Se, K, Mg), but for Fe, the opposite trend was found...
March 27, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28346037/prognostic-significance-of-granulomas-in-children-with-crohn-s-disease
#6
Benjamin Rothschild, Firas Rinawi, Yonatan Herman, Osnat Nir, Raanan Shamir, Amit Assa
OBJECTIVES: Granulomas have long been considered the histological hallmark of Crohn's disease (CD). Currently, there is considerable dispute with regards to their prognostic implications. We aimed to determine the effect of granulomas on phenotypic features and disease's long-term outcomes in a large cohort of pediatric CD patients. MATERIALS AND METHODS: Medical records of pediatric CD patients diagnosed at the Schneider Children's Medical Center were reviewed retrospectively...
March 27, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28345963/accumulation-and-speciation-of-cd-in-avicennia-marina-tissues
#7
Li Jian, Yan Chongling, Du Daolin, Lu Haoliang, Liu Jingchun
Avicennia marina is a high Cd tolerant species in the mangrove wetlands. A hydroponic experiment was carried out to research the accumulation and chemical form distribution of Cd in the tissues of A. marina under different concentration and time of Cd stress. It was found that the concentrations of Cd in plant tissues followed the order of root> stem>leaf. The data suggested that root activity decreased, Cd accumulation ability weakened in roots and the Translocation Factor increased in stems and leaves with the increase of stress time...
March 27, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28345883/cluster-organic-frameworks-constructed-from-heterometallic-supertetrahedral-cluster-secondary-building-units
#8
Li-Dan Lin, Xin-Xiong Li, Yan-Jie Qi, Xiang Ma, Shou-Tian Zheng
The two novel cluster organic frameworks based on heterometallic supertetrahedral cluster secondary building units (SBUs) [Cd4Cu6(L)4(Ac)7(H2O)4](Ac)·7H2O (1) and [Mn4Cu6(L)4(Ac)4.5(H2O)9]CuCN(Ac)3.5·H2O (2), where H3L = 2-(hydroxymethyl)-2-(pyridin-4-yl)-1,3-propanediol and Ac = CH3COO(-), have been prepared under solvothermal conditions. 1 and 2 are the first cases of cluster organic frameworks containing Cd-Cu/Mn-Cu heterometallic supertetrahedral cluster SBUs. Furthermore, 1 and 2 show an integration of magnetic properties and adsorption properties from both the heterometallic cluster secondary building units and the framework in a porous material...
March 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28345827/polycyclic-aromatic-hydrocarbons-in-edible-mushrooms-from-niger-delta-nigeria-carcinogenic-and-non-carcinogenic-health-risk-assessment
#9
Sorbari Igbiri, Nnaemeka Arinze Udowelle, Osazuwa Clinton Ekhator, Rose Ngozi Asomugha, Zelinjo Nkeiruka Igweze, Orish Ebere Orisakwe
In the oil-rich Niger Delta, hydrocarbon pollution and oil spillages, gas flaring and sundry anthropogenic activities constitute sources of polycyclic aromatic hydrocarbons (PAHs), with food contamination playing a major role in human exposure. In this study we assessed PAH levels in wild and cultivated edible mushroom species consumed by the general population from the oil producing Niger Delta, Nigeria. The concentrations of USEPA-16 PAHs were determined by gas chromatography and carcinogenic and non-carcinogenic health risks were calculated...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345727/intrinsic-defects-and-their-effects-on-the-optical-properties-in-the-nonlinear-optical-crystal-cdsip2-a-first-principles-study
#10
Ci Wang, Jie Sun, Huiyang Gou, Shanpeng Wang, Jian Zhang, Xutang Tao
In view of their high nonlinear optical coefficients and good phase-matching properties, CdSiP2 (CSP) crystals are considered as one of the most promising materials in the field of nonlinear optical applications. However, the slight absorption losses around 1.34 μm and 1.78 μm under e-polarized light have been affecting its performance. In this study, first-principles calculations were performed to identify the effects of various charge defects on the absorption properties. Different intrinsic defects in the CSP crystal were calculated using the HSE method and compared according to the specific chemical environments in the experiments...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28345381/comparison-of-fenton-s-reagent-and-adsorption-for-treatment-of-industrial-container-and-drum-cleaning-industry-wastewater
#11
Elçin Güneş, Deniz İzlen Çifçi, Suna Özden Çelik
The present study is aimed to explore the characterization of Industrial Container and Drum Cleaning (ICDC) industry wastewater and treatment alternatives of this wastewater using Fenton and adsorption processes. Wastewater derived from ICDC industry is usually treated by chemical coagulation and biological treatment in Turkey and then discharged in a centralized wastewater treatment facility. It is required that the wastewater COD is below 1500 mg/L to treat in a centralized wastewater treatment facility The wastewater samples characterized for parameters of pH, conductivity, COD, BOD5, TSS, NH3-N, TN, TOC, TP, Cd, Cr, Cu, Fe, Ni, Pb, Zn, Hg...
March 27, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28345108/specific-contributions-of-age-of-onset-callous-unemotional-traits-and-impulsivity-to-reactive-and-proactive-aggression-in-youths-with-conduct-disorders
#12
Sébastien Urben, Stéphanie Habersaat, Sandrine Pihet, Maya Suter, Jill de Ridder, Philippe Stéphan
Youths with conduct disorders (CD) are particularly studied for their violent and aggressive behaviors. Many researchers considered aggressive behaviors as being either reactive or proactive. Moreover, factors such as age of CD onset, impulsivity, and callous-unemotional traits, separately, have been related to these different types of aggressive behaviors. However, very few studies addressed the combined contribution of these three factors on proactive and reactive aggression. This question was tested in a sample composed of 43 male adolescents with CD...
March 27, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28345062/secondary-structure-propensity-and-chirality-of-the-amyloidophilic-peptide-p5-and-its-analogues-impacts-ligand-binding-in-vitro-characterization
#13
Jonathan S Wall, Angela Williams, Craig Wooliver, Emily B Martin, Xiaolin Cheng, R Eric Heidel, Stephen J Kennel
BACKGROUND: Polybasic helical peptides, such as peptide p5, bind human amyloid extracts and synthetic amyloid fibrils. When radiolabeled, peptide p5 has been shown to specifically bind amyloid in vivo thereby allowing imaging of the disease. Structural requirements for heparin and amyloid binding have been studied using analogs of p5 that modify helicity and chirality. METHODS: Peptide-ligand interactions were studied using CD spectroscopy and solution-phase binding assays with radiolabeled p5 analogs...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28344795/validation-of-a-tool-predicting-important-findings-on-computed-tomography-among-crohn-s-disease-patients
#14
REVIEW
Shail M Govani, Akbar K Waljee, Keith E Kocher, Jason M Swoger, Melissa Saul, Peter Dr Higgins
BACKGROUND: Patients with Crohn's disease (CD) are frequently subjected to computed tomography (CT) in the emergency department (ED). This young population is at higher risk of malignancy from radiation exposure. OBJECTIVES: We aimed to validate a decision tool predicting complications (perforation, abscess or other serious finding) on imaging at two sites. METHODS: We conducted a retrospective review of CT outcomes among patients with CD with ED visits at two tertiary care centers...
March 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28344495/enantioselective-analysis-of-fluoxetine-in-pharmaceutical-formulations-by-capillary-zone-electrophoresis
#15
Melania Cârcu-Dobrin, Monica Budău, Gabriel Hancu, Laszlo Gagyi, Aura Rusu, Hajnal Kelemen
Fluoxetine is an antidepressant, a selective serotonin reuptake inhibitor (SSRI) used primarily in the treatment of major depression, panic disorder and obsessive compulsive disorder. Chiral separation of racemic fluoxetine is necessary due to its enantioselective metabolism. In order to develop a suitable method for chiral separation of fluoxetine, cyclodextrin (CD) modified capillary electrophoresis (CE) was employed. A large number of native and derivatized, neutral and ionized CD derivatives were screened to find the optimal chiral selector...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28344208/clinical-outcomes-of-repetition-of-drug-coated-balloon-for-femoropopliteal-restenosis-after-drug-coated-balloon-treatment
#16
Shih-Jung Jang, Hsin-Hua Chou, Jyh-Ming Jimmy Juang, Chien-An Hsieh, De-Min Duan, Hsuan-Li Huang, Yu-Lin Ko
BACKGROUND: To compare the clinical outcomes of patients undergoing repeated drug-coated balloon (DCB) treatment for femoropopliteal (FP) DCB restenosis with those of patients without repetition-DCB.Methods and Results:From March 2013 to September 2014, 102 patients (118 affected legs) underwent DCB for symptomatic FP disease; 47 patients had restenosis, and 37 underwent reintervention over a 45-month follow-up. We compared the outcomes of repetition-DCB for DCB restenosis with those of patients without repetition...
March 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28343956/effect-of-cd-2-and-cd-2-auxin-mixtures-on-lipid-monolayers-model-membrane-studies-on-the-role-of-auxins-in-phytoremediation-of-metal-ions-from-contaminated-environment
#17
Katarzyna Hąc-Wydro, Marzena Mach, Karolina Węder, Katarzyna Pająk, Paweł Wydro
In this work Langmuir monolayer experiments were performed to analyze the effect of Cd(2+) ions and their mixtures with synthetic auxin (1-naphthaleneacetic acid - NAA) on lipid films. These investigations were motivated by the fact that auxins act effectively as the agents improving the removal of metal ions from contaminated water and soil by plants (phytoextraction), and although their mechanism of action in this area is still unclear, it was suggested that it can be membrane-related. The experiments were done for one component (1,2-dipalmitoyl-sn-glycero-3-phosphocholine - DPPC; 1,2-dioleoyl-sn-glycero-3-phosphocholine - DOPC; 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) - DPPG) monolayers and mixed (DPPG/DOPC and DPPG/DPPC) films treated as model of plant leaves membranes...
March 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28343876/constituents-with-potent-%C3%AE-glucosidase-inhibitory-activity-from-pueraria-lobata-willd-ohwi
#18
Xiao-Ling Wang, Fu-Rong Jiao, Meng Yu, Li-Bin Lin, Jian Xiao, Qiang Zhang, Le Wang, Dong-Zhu Duan, Gang Xie
One new flavone hydrate named lobatflavate (1), one new chromone named lobatchrosin (2), and one new isoflavone named 3S,4R-tuberosin (3), along with four known isoflavone analogues (4-7), were isolated from the traditional Chinese medicinal plant of Pueraria lobata (Willd.) ohwi. Their structures were elucidated by extensive spectroscopic methods of IR, UV, HR-ESI-MS, 1D and 2D NMR. The absolute configuration of 3 was determined by CD spectrum associated with TD-DFT calculation analysis. All compounds except for 2 were assayed the inhibitory activity against α-glucosidase...
March 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28343753/limnothrix-sp-ko05-a-newly-characterized-cyanobacterial-biosorbent-for-cadmium-removal-the-enzymatic-and-non-enzymatic-antioxidant-reactions-to-cadmium-toxicity
#19
Omid Haghighi, Shahab Shahryari, Mojgan Ebadi, Sima Modiri, Hossein Shahbani Zahiri, Hadi Maleki, Kambiz Akbari Noghabi
In this study, we isolated five indigenous cyanobacterial strains from different aqueous environments, with heavy metals contamination, in East Azerbaijan Province (northwest portion of Iran). A strain was identified by morphological and 16S rRNA sequence analysis as Limnothrix sp. KO05 and selected for further studies as having the greatest potential for cadmium uptake. Scanning electron microscopy (SEM) demonstrated cyanobacterium Limnothrix sp. KO05 forms filamentous structures and is straight or curved to some extent...
March 18, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28343658/text-message-intervention-teach-improves-quality-of-life-and-patient-activation-in-celiac-disease-a-randomized-clinical-trial
#20
Kelly Haas, Andrew Martin, K T Park
OBJECTIVE: To determine the impact of the Text Message Educational Automated Compliance Help (TEACH) text message intervention as a pragmatic approach for patient engagement among adolescents with celiac disease (CD) as measured by gluten-free diet (GFD) adherence, patient activation, and quality of life (QOL). STUDY DESIGN: Randomized controlled trial with patient recruitment at a pediatric, university-based hospital and through social media; 61 participants ages 12-24 years with CD diagnosed at least 1 year were enrolled...
March 23, 2017: Journal of Pediatrics
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