keyword
https://read.qxmd.com/read/38535586/unveiling-the-dual-threat-how-microbial-infections-and-healthcare-deficiencies-fuel-cervical-and-prostate-cancer-deaths-in-africa
#1
REVIEW
Sofian Abdul-Nasir, Hyungdon Lee, Md Habibur Rahman, Johny Bajgai, Kyu-Jae Lee, Cheol-Su Kim, Soo-Ki Kim
Cervical and prostate cancer account for 7.1 and 7.3 deaths per 100,000 people globally in 2022. These rates increased significantly to 17.6 and 17.3 in Africa, respectively, making them the second and third leading cause of cancer deaths in Africa, only surpassed by breast cancer. The human papillomavirus is the prime risk factor for cervical cancer infection. On the other hand, prostate cancer risks include ageing, genetics, race, geography, and family history. However, these factors alone cannot account for the high mortality rate in Africa, which is more than twice the global mortality rate for the two cancers...
March 10, 2024: Pathogens
https://read.qxmd.com/read/38534919/review-on-the-role-of-brca-mutations-in-genomic-screening-and-risk-stratification-of-prostate-cancer
#2
REVIEW
Nikolaos Kalampokis, Christos Zabaftis, Theodoros Spinos, Markos Karavitakis, Ioannis Leotsakos, Ioannis Katafigiotis, Henk van der Poel, Nikolaos Grivas, Dionysios Mitropoulos
(1) Background: Somatic and germline alterations can be commonly found in prostate cancer (PCa) patients. The aim of our present study was to perform a comprehensive review of the current literature in order to examine the impact of BRCA mutations in the context of PCa as well as their significance as genetic biomarkers. (2) Methods: A narrative review of all the available literature was performed. Only "landmark" publications were included. (3) Results: Overall, the number of PCa patients who harbor a BRCA2 mutation range between 1...
February 22, 2024: Current Oncology
https://read.qxmd.com/read/38534493/a-comprehensive-review-on-synergy-of-multi-modal-data-and-ai-technologies-in-medical-diagnosis
#3
REVIEW
Xi Xu, Jianqiang Li, Zhichao Zhu, Linna Zhao, Huina Wang, Changwei Song, Yining Chen, Qing Zhao, Jijiang Yang, Yan Pei
Disease diagnosis represents a critical and arduous endeavor within the medical field. Artificial intelligence (AI) techniques, spanning from machine learning and deep learning to large model paradigms, stand poised to significantly augment physicians in rendering more evidence-based decisions, thus presenting a pioneering solution for clinical practice. Traditionally, the amalgamation of diverse medical data modalities (e.g., image, text, speech, genetic data, physiological signals) is imperative to facilitate a comprehensive disease analysis, a topic of burgeoning interest among both researchers and clinicians in recent times...
February 25, 2024: Bioengineering
https://read.qxmd.com/read/38534368/unique-spatial-transcriptomic-profiling-of-the-murine-femoral-fracture-callus-a-preliminary-report
#4
JOURNAL ARTICLE
Will Jiang, Dennis L Caruana, Jungho Back, Francis Y Lee
Fracture callus formation is a dynamic stage of bone activity and repair with precise, spatially localized gene expression. Metastatic breast cancer impairs fracture healing by disrupting bone homeostasis and imparting an altered genomic profile. Previous sequencing techniques such as single-cell RNA and in situ hybridization are limited by missing spatial context and low throughput, respectively. We present a preliminary approach using the Visium CytAssist spatial transcriptomics platform to provide the first spatially intact characterization of genetic expression changes within an orthopedic model of impaired fracture healing...
March 16, 2024: Cells
https://read.qxmd.com/read/38533706/establishment-of-patient-derived-organoids-for-guiding-personalized-therapies-in-breast-cancer-patients
#5
JOURNAL ARTICLE
Huizi Wu, Weiwei Wang, Yinbin Zhang, Yinxi Chen, Changyou Shan, Jia Li, Yiwei Jia, Chaofan Li, Chong Du, Yifan Cai, Yu Zhang, Shuqun Zhang, Fei Wu
Breast cancer has become the most commonly diagnosed cancer. The intra- and interpatient heterogeneity induced a considerable variation in treatment efficacy. There is an urgent requirement for preclinical models to anticipate the effectiveness of individualized drug responses. Patient-derived organoids (PDOs) can accurately recapitulate the architecture and biological characteristics of the origin tumor, making them a promising model that can overtake many limitations of cell lines and PDXs. However, it is still unclear whether PDOs-based drug testing can benefit breast cancer patients, particularly those with tumor recurrence or treatment resistance...
March 27, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38533207/integrative-analysis-identifies-cancer-cell-intrinsic-rarres1-as-a-predictor-of-prognosis-and-immune-response-in-triple-negative-breast-cancer
#6
JOURNAL ARTICLE
Zhengheng Yu, Hongjin Liu, Jingming Ye, Yinhua Liu, Ling Xin, Qian Liu, Yuanjia Cheng, Lu Yin, Ling Xu
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and limited treatment options. Although immune checkpoint inhibitors (ICIs) have been proven to improve outcomes in TNBC patients, the potential mechanisms and markers that determine the therapeutic response to ICIs remains uncertain. Revealing the relationship and interaction between cancer cells and tumor microenvironment (TME) could be helpful in predicting treatment efficacy and developing novel therapeutic agents. By analyzing single-cell RNA sequencing dataset, we comprehensively profiled cell types and subpopulations as well as identified their signatures in the TME of TNBC...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38531482/dipeptidyl-peptidase-9-regulates-the-dynamics-of-tumorigenesis-and-metastasis-in-breast-cancer
#7
JOURNAL ARTICLE
Lisa Heß, Kazeera Aliar, Barbara T Grünwald, Ricarda Griffin, Alina Lozan, Mariel Knöller, Rama Khokha, Tilman Brummer, Thomas Reinheckel
The cytosolic dipeptidyl-aminopeptidase 9 (DPP9) cleaves protein N-termini post-proline or -alanine. Our analysis of DPP9 mRNA expression from the TCGA 'breast cancer' data set revealed that low/intermediate DPP9 levels are associated with poor overall survival of breast cancer patients. To unravel the impact of DPP9 on breast cancer development and progression, the transgenic MMTV-PyMT mouse model of metastasizing breast cancer was used. In addition, tissue- and time-controlled genetic deletion of DPP9 by the Cre-loxP recombination system was done...
March 24, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38530139/fenretinide-in-young-women-at-genetic-or-familial-risk-of-breast-cancer-a-placebo-controlled-biomarker-trial
#8
JOURNAL ARTICLE
Valentina Aristarco, Davide Serrano, Patrick Maisonneuve, Aliana Guerrieri-Gonzaga, Matteo Lazzeroni, Irene Feroce, Debora Macis, Elena Cavadini, Elena Albertazzi, Costantino Jemos, Emanuela Omodeo Salè, Laura Cortesi, Samuele Massarut, Marcella Gulisano, Maria Grazia Daidone, Harriet Johansson, Bernardo Bonanni
Fenretinide, a retinoid with a low toxicity profile that accumulates in the breast, has been shown to prevent second breast cancer in young women. Fenretinide exhibits apoptotic and anti-invasive properties and it improves insulin sensitivity in overweight premenopausal women with insulin resistance. The present study aimed to further characterize its role in cancer prevention by measuring circulating biomarkers related to insulin sensitivity and breast cancer risk. Sixty-two women, aged 20 to 46 years, healthy or who had already undergone breast cancer surgery, with a known BRCA1/2 mutation or a likelihood of mutation ≥ 20% according to the BRCAPRO model, were randomly assigned to receive fenretinide (200 mg/day) or placebo for 5 years (trial registration: EudraCT Number: 2009-010260-41)...
March 26, 2024: Cancer Prevention Research
https://read.qxmd.com/read/38529831/the-ameliorative-effect-of-rosmarinic-acid-and-epigallocatechin-gallate-against-doxorubicin-induced-genotoxicity
#9
JOURNAL ARTICLE
Sinem Helvacioglu, Mohammad Charehsaz, Ezgi Eyluel Bankoglu, Helga Stopper, Ahmet Aydin
Doxorubicin (Dox), an effective anticancer agent, is known for its genotoxic effects on normal cells. Phenolic compounds, renowned for their antitumor, antioxidant, and antigenotoxic properties, have gained prominence in recent years. This study investigates the individual and combined protective effects of rosmarinic acid (RA) and epigallocatechin gallate (EGCG) against Dox-induced genotoxicity using various in vitro test systems. The synergistic/antagonistic interaction of these combinations on Dox's chemotherapeutic effect is explored in breast cancer cell lines...
March 26, 2024: Drug and Chemical Toxicology
https://read.qxmd.com/read/38527495/long-term-multimodal-recording-reveals-epigenetic-adaptation-routes-in-dormant-breast-cancer-cells
#10
JOURNAL ARTICLE
Dalia Rosano, Emre Sofyali, Heena Dhiman, Chiara Ghirardi, Diana Ivanoiu, Timon Heide, Andrea Vingiani, Alessia Bertolotti, Giancarlo Pruneri, Eleonora Canale, Hannah F Dewhurst, Debjani Saha, Neil Slaven, Iros Barozzi, Tong Li, Grigory Zemlyanskiy, Henry Phillips, Chela James, Balázs Győrffy, Claire Lynn, George D Cresswell, Farah Rehman, Roberta Noberini, Tiziana Bonaldi, Andrea Sottoriva, Luca Magnani
UNLABELLED: Patients with estrogen receptor-positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients relapse even decades after surgery through unknown mechanisms likely involving dormancy. To investigate genetic and transcriptional changes underlying tumor awakening, we analyzed late relapse patients and longitudinally profiled a rare cohort treated with long-term neoadjuvant ETs until progression...
March 21, 2024: Cancer Discovery
https://read.qxmd.com/read/38527110/genetic-analysis-of-palb2-gene-wd40-domain-in-canine-mammary-tumour-patients
#11
JOURNAL ARTICLE
Özge Şebnem Çıldır, Özge Özmen, Selim Kul, Ali Rişvanlı, Gözde Özalp, Ahmet Sabuncu, Oğuz Kul
BACKGROUND: DNA repair mechanisms are essential for tumorigenesis and disruption of HR mechanism is an important predisposing factor of human breast cancers (BC). PALB2 is an important part of the HR. There are similarities between canine mammary tumours (CMT) and BCs. As its human counterpart, PALB2 mutations could be a predisposing factor of CMT. OBJECTIVES: In this study, we aimed to investigate the impacts of PALB2 variants on tumorigenesis and canine mammary tumor (CMT) malignancy...
May 2024: Veterinary Medicine and Science
https://read.qxmd.com/read/38526855/genetic-determinants-of-taxane-induced-peripheral-neuropathy
#12
JOURNAL ARTICLE
Beata Mladosievicova, Magdalena Nemcokova Jablonicka, Lucia Tatayova, Michal Bernadic
The efficacy of taxane‑containing regimens has been demonstrated for various cancers, particularly ovarian, endometrial, breast, lung, and prostate cancers. However, extensive taxane-induced toxicities limit their use. Prediction and management of many toxic complications in cancer patients have evolved significantly over the last decade. Peripheral neuropathy is the most typical non-hematological taxane-related complication, and it has a multifactorial pathogenesis. It is often dose-dependent and progressive during therapy and sometimes even after treatment...
2024: Bratislavské Lekárske Listy
https://read.qxmd.com/read/38525814/withaferin-a-alters-the-expression-of-micrornas-146a-5p-and-34a-5p-and-associated-hub-genes-in-mda-mb-231-cells
#13
JOURNAL ARTICLE
Mohd Shuaib, Smriti Chaudhri, Shashank Kumar
Triple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer. Due to the absence of obvious therapeutic targets, microRNAs (miRNAs) provide possible hope to treat TNBC. Withaferin A (WA), a steroidal lactone, possesses potential anticancer activity with lesser side effects. The present study identifies hub genes ( CDKN3 , TRAF6 , CCND1 , JAK1 , MET , AXIN2 , JAG1 , VEGFA , BRCA1 , E2F3 , WNT1 , CDK6 , KRAS , MYB , MYCN , TGFβR2 , NOTCH1 , SIRT1 , MYCN , NOTCH2 , WNT3A ) from the list of predicted targets of the differentially expressed miRNAs (DEMs) in WA-treated MDA-MB-231 cells using in silico protein-protein interaction network analysis...
January 1, 2024: Biomolecular Concepts
https://read.qxmd.com/read/38525245/fibroblast-heterogeneity-and-functions-insights-from-single-cell-sequencing-in-wound-healing-breast-cancer-ovarian-cancer-and-melanoma
#14
REVIEW
Omar Lujano Olazaba, Jeffrey Farrow, Teresa Monkkonen
Cancer has been described as the wound that does not heal, in large part due to fibroblast involvement. Activation of cancer-associated fibroblasts (CAFs) contributes to critical features of the tumor microenvironment, including upregulation of key marker proteins, recruitment of immune cells, and deposition of extracellular matrix (ECM)-similar to fibroblast activation in injury-induced wound healing. Prior to the widespread availability of single-cell RNA sequencing (scRNA seq), studies of CAFs or fibroblasts in wound healing largely relied on models guided by individual fibroblast markers, or methods with less resolution to unravel the heterogeneous nature of CAFs and wound healing fibroblasts (especially regarding scarring outcome)...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38524848/artificially-sweetened-beverages-consumption-and-risk-of-obesity-related-cancers-a-wide-angled-mendelian-randomization-study
#15
JOURNAL ARTICLE
Xing Jin, Mengyue Wu, Shuangshuang Dong, Hui Liu, Haochuan Ma
BACKGROUND: The impact of artificially sweetened beverages (ASBs) consumption on obesity-related cancers (ORCs) risk remains controversial. To address this challenging issue, this study employed wide-angle mendelian randomization (MR) analyses to explore the genetic causality between ASB consumption and the risk of ORCs, thereby effectively minimizing the impact of external confounders. METHODS: We conducted a suite of analyses encompassing univariable, multivariable, and two-step MR to evaluate causal associations between ASB consumption (samples = 85,852) and risk of ORCs (total samples = 2,974,770) using summary statistics from genome-wide association studies (GWAS)...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38524651/a-case-of-hereditary-breast-and-ovarian-cancer-syndrome-of-initially-presented-as-cancer-of-unknown-primary-with-lymph-node-metastases-unveiled-by-genetic-analysis
#16
JOURNAL ARTICLE
Juri Yamada, Koji Fukuda, Tae Sugawara, Kenichi Makino, Kazuhiro Shimazu, Taichi Yoshida, Daiki Taguchi, Hanae Shinozaki, Yukihiro Terada, Hiroshi Nanjo, Hiroyuki Shibata
Cancer of unknown primary (CUP) is a heterogeneous disease concept involving various malignant tumors. Understanding its pathophysiology is often difficult, together with its treatment. Here, we present a case of CUP with abdominal lymph node enlargement and elevated carbohydrate antigen 125 levels. It initially resembled a favorable prognosis type similar to ovarian cancer, but metastases were observed in cervical lymph nodes, indicating a somewhat atypical CUP compared to the typical ovarian cancer-like CUP...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524061/paget-s-presentation-of-high-grade-ductal-carcinoma-in-situ-dcis-in-a-very-young-female-with-breast-cancer-2-brca2-mutation
#17
Sneha Butala, Chancée Forestier, Sugeetha Nithiananthan, Asilis J Defran, Nafisa K Kuwajerwala
This is a case of a previously healthy 29-year-old female with erythema and skin excoriations of the left breast nipple-areolar complex (NAC). After a repeat trial and failure of topical hydrocortisone, a diagnostic mammogram and nipple biopsy revealed Paget's disease (PD) of the nipple with ductal carcinoma in situ (DCIS). A subsequent genetic analysis found a breast cancer 2 ( BRCA2 ) gene mutation. Treatment consisted of a left breast skin-sparing simple mastectomy with sentinel lymph node (SLN) biopsy and immediate tissue expander placement for implant reconstruction...
February 2024: Curēus
https://read.qxmd.com/read/38524002/mutation-of-pten-loss-and-likelihood-of-being-a-non-responder-to-trastuzumab-in-a-sample-of-iraqi-her2-breast-cancer-patients
#18
JOURNAL ARTICLE
Alyaa H Hammadi, Shatha H Ali
INTRODUCTION: PTEN controls upstream PI3K relatives, such as AKT. PTEN gene mutations have been documented to affect outcomes in main or distant malignancies, including breast cancer (BC). PTEN gene deletions are common in a variety of human cancers. A key factor in the response to this kind of therapy is genetic diversity. The purpose of this research is to determine whether a PTEN loss mutation influences a patient's propensity to not respond to trastuzumab (TRS) in cases of Her2+ BC...
February 2024: Curēus
https://read.qxmd.com/read/38520597/germline-pathogenic-variants-associated-with-triple-negative-breast-cancer-in-us-hispanic-and-guatemalan-women-using-hospital-and-community-based-recruitment-strategies
#19
JOURNAL ARTICLE
Jesica M Godinez Paredes, Isabel Rodriguez, Megan Ren, Anali Orozco, Jeremy Ortiz, Anaseidy Albanez, Catherine Jones, Zeina Nahleh, Lilian Barreda, Lisa Garland, Edmundo Torres-Gonzalez, Dongjing Wu, Wen Luo, Jia Liu, Victor Argueta, Roberto Orozco, Eduardo Gharzouzi, Michael Dean
PURPOSE: Recruit and sequence breast cancer subjects in Guatemalan and US Hispanic populations. Identify optimum strategies to recruit Latin American and Hispanic women into genetic studies of breast cancer. METHODS: We used targeted gene sequencing to identify pathogenic variants in 19 familial breast cancer susceptibility genes in DNA from unselected Hispanic breast cancer cases in the US and Guatemala. Recruitment across the US was achieved through community-based strategies...
March 23, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38519482/proteomic-profiling-reveals-that-esr1-mutations-enhance-cyclin-dependent-kinase-signaling
#20
JOURNAL ARTICLE
Tommaso De Marchi, Chun-Fui Lai, Georgia M Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H Saal, Johan Malmström, Simak Ali, Emma Niméus
Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibitors. ESR1 mutations promote constitutive ER activity and affect other signaling pathways, allowing cancer cells to proliferate by employing mechanisms within and without direct regulation by the ER. Although subjected to extensive genetic and transcriptomic analyses, understanding of protein alterations remains poorly investigated...
March 22, 2024: Scientific Reports
keyword
keyword
105820
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.