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https://www.readbyqxmd.com/read/29656476/topiramate-induced-secondary-angle-closure-salient-points-in-management
#1
Lewis Lam, Nancy Wang, Sue Ormonde, Michael Merriman
No abstract text is available yet for this article.
April 15, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29656437/structural-correlates-of-openness-and-intellect-implications-for-the-contribution-of-personality-to-creativity
#2
Oshin Vartanian, Christopher J Wertz, Ranee A Flores, Erin L Beatty, Ingrid Smith, Kristen Blackler, Quan Lam, Rex E Jung
Openness/Intellect (i.e., openness to experience) is the Big Five personality factor most consistently associated with individual differences in creativity. Recent psychometric evidence has demonstrated that this factor consists of two distinct aspects-Intellect and Openness. Whereas Intellect reflects perceived intelligence and intellectual engagement, Openness reflects engagement with fantasy, perception, and aesthetics. We investigated the extent to which Openness and Intellect are associated with variations in brain structure as measured by cortical thickness, area, and volume (N = 185)...
April 15, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29656330/risk-factors-for-anatomic-pelvic-organ-prolapse-at-6-weeks-postpartum-a-prospective-observational-study
#3
Cathrine Reimers, Franziska Siafarikas, Jette Stær-Jensen, Milada Cvancarova Småstuen, Kari Bø, Marie Ellström Engh
INTRODUCTION AND HYPOTHESIS: The objective was to identify risk factors for postpartum anatomic pelvic organ prolapse (aPOP) by comparing women with and without aPOP at 6 weeks postpartum with regard to pelvic floor measurements antepartum and obstetrical characteristics. METHODS: We carried out a prospective observational cohort study including nulliparous pregnant women in a Norwegian university hospital. Participants underwent clinical examinations, including pelvic organ prolapse quantification system (POP-Q) and transperineal ultrasound at gestational week 21 and at 6 weeks postpartum...
April 14, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29656048/trunk-muscle-quality-assessed-by-computed-tomography-association-with-adiposity-indices-and-glucose-tolerance-in-men
#4
Alexandre Maltais, Natalie Alméras, Isabelle Lemieux, Angelo Tremblay, Jean Bergeron, Paul Poirier, Jean-Pierre Després
BACKGROUND/OBJECTIVES: Thigh muscle attenuation measured by computed tomography (CT) has been shown to be a reliable and useful index of skeletal muscle fat infiltration. Thigh muscle fat content assessed by CT has been linked to obesity and type 2 diabetes and is a correlate of insulin resistance in sedentary individuals. However, as measurement of mid-thigh fat content requires the assessment of another region of interest beyond the usual abdominal scan required to measure levels of visceral and subcutaneous abdominal adipose tissue, this study aimed at testing the hypothesis that skeletal muscle fat measured from a single abdominal scan (L4 -L5 ) would also provide information relevant to the estimation of muscle fat infiltration as it relates to cardiometabolic risk...
April 12, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29655704/a-library-of-phosphoproteomic-and-chromatin-signatures-for-characterizing-cellular-responses-to-drug-perturbations
#5
Lev Litichevskiy, Ryan Peckner, Jennifer G Abelin, Jacob K Asiedu, Amanda L Creech, John F Davis, Desiree Davison, Caitlin M Dunning, Jarrett D Egertson, Shawn Egri, Joshua Gould, Tak Ko, Sarah A Johnson, David L Lahr, Daniel Lam, Zihan Liu, Nicholas J Lyons, Xiaodong Lu, Brendan X MacLean, Alison E Mungenast, Adam Officer, Ted E Natoli, Malvina Papanastasiou, Jinal Patel, Vagisha Sharma, Courtney Toder, Andrew A Tubelli, Jennie Z Young, Steven A Carr, Todd R Golub, Aravind Subramanian, Michael J MacCoss, Li-Huei Tsai, Jacob D Jaffe
Although the value of proteomics has been demonstrated, cost and scale are typically prohibitive, and gene expression profiling remains dominant for characterizing cellular responses to perturbations. However, high-throughput sentinel assays provide an opportunity for proteomics to contribute at a meaningful scale. We present a systematic library resource (90 drugs × 6 cell lines) of proteomic signatures that measure changes in the reduced-representation phosphoproteome (P100) and changes in epigenetic marks on histones (GCP)...
April 10, 2018: Cell Systems
https://www.readbyqxmd.com/read/29655445/risk-management-in-port-and-maritime-logistics
#6
EDITORIAL
Jasmine Siu Lee Lam, Y H Venus Lun, Michael G H Bell
No abstract text is available yet for this article.
April 11, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29653181/zh-1-enhances-the-anticancer-activity-of-gemcitabine-via-deoxyribonucleotide-synthesis-and-apoptotic-pathway-against-a549-cells
#7
Jianru Guo, Yan Li, Christopher Wai Kei Lam, Caiyun Wang, Meicun Yao, Wei Zhang
The purpose of this study was to investigate the inhibitory effect of ZH-1 ((6S,9aS,6aR,9bR)-6-(phenylcarbonyl)-6,6a,9a,9b-tetrahydro-8H-azolidino[3,4-a]b enzo [e]indolizine-7,9-dione) and its potential interactions with gemcitabine in A549 cells. MTT assay showed that the combined use of gemcitabine and ZH-1 presented a significant inhibition effect on A549 cell growth with the cell viability from 82.3 ± 5.6% to 51.0 ± 6.6%. The CI value was 0.60 suggesting a synergistic effect between these two drugs...
April 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29652753/hybrid-extracorporeal-therapies-as-a-bridge-to-pediatric-liver-transplantation
#8
Ayse Akcan Arikan, Poyyapakkam Srivaths, Ryan W Himes, Naile Tufan Pekkucuksen, Fong Lam, Trung Nguyen, Tamir Miloh, Michael Braun, John Goss, Moreshwar S Desai
OBJECTIVES: Standard intensive care treatment is inadequate to keep children with liver failure alive without catastrophic complications to ensure successful transplant, as accumulation of endogenous protein-bound toxins often lead to hepatic encephalopathy, hepatorenal syndrome, cardiovascular instability, and multiple organ failure. Given paucity of proven treatment modalities for liver failure, blood purification using different extracorporeal treatments as a bridge to transplantation is used, but studies evaluating the safety and efficacy of combination of these therapies, especially in pediatric liver failure, are lacking...
April 12, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29652628/salience-and-impact-of-health-warning-label-on-cigarette-packs-in-vietnam-findings-from-the-global-adult-tobacco-survey-2015
#9
Nguyen Ngoc Bich, Tran Thu Ngan, Kim Bao Giang, Phan Thi Hai, Doan Thi Thu Huyen, Luong Ngoc Khue, Nguyen Tuan Lam, Hoang Van Minh, Pham Thi Quynh Nga, Nguyen The Quan, Vu Hoang Loan
Viet Nam is among the countries having highest rate of male smokers in the world. The country has joined the Global Tobacco Surveillance System since 2010. Under this system, two rounds of Global Adult Tobacco Survey (GATS) were conducted in 2010 and 2015. Those two surveys provide excellent comparable data on tobacco usage and its related aspects in Vietnam. This study using the data from GATS 2015 to examine the salience and impact of cigarette pack health warnings on quitting intention in Vietnam. The Vietnam GATS 2015 was a nationally representative survey in which 9,513 households were selected using two-stage random systematic sampling method...
April 13, 2018: Behavioral Medicine
https://www.readbyqxmd.com/read/29652081/eight-year-follow-up-of-a-randomized-clinical-trial-comparing-ultrasound-guided-foam-sclerotherapy-with-surgical-stripping-of-the-great-saphenous-vein
#10
Y L Lam, J A Lawson, I M Toonder, N H Shadid, A Sommer, M Veenstra, A M J van der Kleij, R P Ceulen, E de Haan, F Ibrahim, T van Dooren, F H Nieman, C H A Wittens
BACKGROUND: This was an 8-year follow-up of an RCT comparing ultrasound-guided foam sclerotherapy (UGFS) with high ligation and surgical stripping (HL/S) of the great saphenous vein (GSV). METHODS: Patients were randomized to UGFS or HL/S of the GSV. The primary outcome was the recurrence of symptomatic GSV reflux. Secondary outcomes were patterns of reflux according to recurrent varices after surgery, Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification, Venous Clinical Severity Score (VCSS) and EuroQol Five Dimensions (EQ-5D™) quality-of-life scores...
May 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29651878/in-vivo-hypoglycemic-effect-of-kigelia-africana-lam-studies-with-alloxan-induced-diabetic-mice
#11
Stephen M Njogu, Wycliffe M Arika, Alex K Machocho, Joseph J N Ngeranwa, Eliud N M Njagi
The claims by the traditional herbal medicine practitioners that Kigelia africana has bioactivity against several diseases, including diabetes mellitus, were investigated in this study. Type I diabetes mellitus was induced in mice by intraperitoneal administration of alloxan monohydrate followed by treatment with the therapeutic doses of the aqueous and ethyl acetate leaf extract of K africana to the experimentally diabetic mice. The treatment effects were compared with the normal control, diabetic control, and diabetic control rats treated with a standard antidiabetic drugs (insulin administered intraperitoneally at 1 IU/kg body weight in 0...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29651590/effect-of-long-term-acclimatization-on-summer-thermal-comfort-in-outdoor-spaces-a-comparative-study-between-melbourne-and-hong-kong
#12
Cho Kwong Charlie Lam, Kevin Ka-Lun Lau
The Universal Thermal Climate Index (UTCI) is an index for assessing outdoor thermal environment which aims to be applicable universally to different climates. However, the scale of UTCI thermal stress classification can be interpreted depending on the context. Previous studies validated the UTCI in individual cities, but comparative studies between different cities are scarce. This study examines the differences in thermal perception and clothing choices between residents from two climate zones over similar UTCI ranges in summer...
April 12, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29650368/protein-corona-in-response-to-flow-effect-on-protein-concentration-and-structure
#13
Dhanya T Jayaram, Samantha M Pustulka, Robert G Mannino, Wilbur A Lam, Christine K Payne
Nanoparticles used in cellular applications encounter free serum proteins that adsorb onto the surface of the nanoparticle, forming a protein corona. This protein layer controls the interaction of nanoparticles with cells. For nanomedicine applications, it is important to consider how intravenous injection and the subsequent shear flow will affect the protein corona. Our goal was to determine if shear flow changed the composition of the protein corona and if these changes affected cellular binding. Colorimetric assays of protein concentration and gel electrophoresis demonstrate that polystyrene nanoparticles subjected to flow have a greater concentration of serum proteins adsorbed on the surface, especially plasminogen...
April 9, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29645347/does-the-introduction-of-prostate-multiparametric-mri-into-active-surveillance-of-localised-prostate-cancer-improve-patient-re-classification
#14
R J Bryant, B Yang, Y Philippou, K Lam, M Obiakor, J Ayers, V Chiocchia, F Gleeson, R MacPherson, C Verrill, P Sooriakumaran, F C Hamdy, S F Brewster
OBJECTIVES: To determine whether replacement of protocol-driven repeat prostate biopsy (PB) with multiparametric magnetic resonance imaging (mpMRI) +/- targeted repeat prostate biopsy (TB) in evaluating men on active surveillance (AS) for low-volume low- to intermediate-risk prostate cancer (PCa) altered the likelihood or time to treatment, or reduced the number of repeat biopsies required to trigger treatment. PATIENTS AND METHODS: 445 patients underwent AS from 2010-2016 at our institution with median follow-up of 2...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29645309/hydrazo-cest-hydrazone-dependent-chemical-exchange-saturation-transfer-magnetic-resonance-imaging-contrast-agents
#15
Trina Dang, Mojmir Suchy, Yen Truong, Wendy Oakden, Wilfred Lam, Caitlin Lazurko, Glenn Facey, Greg Stanisz, Adam Shuhendler
The rapid formation of hydrazones under physiological conditions was exploited for the detection of aldehydes through chemical exchange saturation transfer magnetic resonance imaging (CEST-MRI). A metal-free, diamagnetic contrast agent derived from N-amino anthranilic acid was introduced, which selectively 'turned-on' upon hydrazone formation through an effect termed Hydrazo-CEST. While the hydrazine form of the probe produced no CEST-MRI signal enhancement, the formation of the aryl hydrazone resulted in >20% intensity decrease in the bulk water signal through the CEST effect, as measured by 300 MHz 1H NMR, 3T and 7T MRI...
April 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29644094/insufficiency-of-dna-repair-enzyme-atm-promotes-naive-cd4-t-cell-loss-in-chronic-hepatitis-c-virus-infection
#16
Juan Zhao, Xindi Dang, Peixin Zhang, Lam Nhat Nguyen, Dechao Cao, Lin Wang, Xiaoyuan Wu, Zheng D Morrison, Ying Zhang, Zhansheng Jia, Qian Xie, Ling Wang, Shunbin Ning, Mohamed El Gazzar, Jonathan P Moorman, Zhi Q Yao
T cells have a crucial role in viral clearance and vaccine response; however, the mechanisms regulating their responses to viral infections or vaccinations remain elusive. In this study, we investigated T-cell homeostasis, apoptosis, DNA damage, and repair machineries in a large cohort of subjects with hepatitis C virus (HCV) infection. We found that naive CD4 T cells in chronically HCV-infected individuals (HCV T cells) were significantly reduced compared with age-matched healthy subjects. In addition, HCV T cells were prone to apoptosis and DNA damage, as evidenced by increased 8-oxoguanine expression and γH2AX/53BP1-formed DNA damage foci-hallmarks of DNA damage responses...
2018: Cell Discovery
https://www.readbyqxmd.com/read/29643798/rapid-capsular-contraction-with-secondary-intraocular-lens-dislocation-associated-with-unspecified-rod-cone-dystrophy-a-case-report
#17
Jocelyn Lam, Bradley Sifrig, Hoon Jung
Purpose: We report an unusual case of rapid and severe anterior capsular contraction associated with secondary intraocular lens (IOL) dislocation following cataract surgery in a patient with unspecified rod-cone dystrophy. Case Report: A 68-year-old woman with a history of uncharacterized bilateral rod-cone dystrophy presented with blurry vision 1 month after cataract surgery. Best corrected visual acuity was 20/40 in the operative eye. Slit-lamp exam showed severe anterior capsular phimosis limiting view of the fundus...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29642916/longitudinal-measurement-invariance-and-explanatory-irt-models-for-adolescents-oral-health-related-quality-of-life
#18
David T W Yau, May C M Wong, K F Lam, Colman McGrath
BACKGROUND: Longitudinal invariance is a perquisite for a valid comparison of oral health-related quality of life (OHRQoL) scores over time. Item response theory (IRT) models can assess measurement invariance and allow better estimation of the associations between predictors and latent construct. By extending IRT models, this study aimed to investigate the longitudinal invariance of the two 8-item short forms of the Child Perception Questionnaire (CPQ11-14 ) regression short form (RSF:8) and item-impact short form (ISF:8) and identify factors associated with adolescents' OHRQoL and its change...
April 11, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29642589/the-molecular-targets-and-anti-invasive-effects-of-2-6-bis-4-hydroxyl-3methoxybenzylidine-cyclohexanone-or-bhmc-in-mda-mb-231-human-breast-cancer-cells
#19
Siti Nor Aini Harun, Daud Ahmad Israf, Chau Ling Tham, Kok Wai Lam, Manraj Singh Cheema, Nur Fariesha Md Hashim
In order to metastasize, tumor cells need to migrate and invade the surrounding tissues. It is important to identify compound(s) capable of disrupting the metastasis of invasive cancer cells, especially for hindering invadopodia formation, so as to provide anti-metastasis targeted therapy. Invadopodia are thought to be specialized actin-rich protrusions formed by highly invasive cancer cells to degrade the extracellular matrix (ECM). A curcuminoid analogue known as 2,6-bis-(4-hydroxy-3-methoxybenzylidine)cyclohexanone or BHMC has shown good potential in inhibiting inflammation and hyperalgesia...
April 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29642405/transcriptome-analysis-of-acute-phase-liver-graft-injury-in-liver-transplantation
#20
Nikki P Lee, Haiyang Wu, Kevin T P Ng, Ruibang Luo, Tak-Wah Lam, Chung-Mau Lo, Kwan Man
BACKGROUND: Liver transplantation remains the treatment of choice for a selected group of hepatocellular carcinoma (HCC) patients. However, the long-term benefit is greatly hampered by post-transplant HCC recurrence. Our previous studies have identified liver graft injury as an acute phase event leading to post-transplant tumor recurrence. METHODS: To re-examine this acute phase event at the molecular level and in an unbiased way, RNA sequencing (RNA-Seq) was performed on liver graft biopsies obtained from the transplant recipients two hours after portal vein reperfusion with an aim to capture frequently altered pathways that account for post-transplant tumor recurrence...
April 6, 2018: Biomedicines
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