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https://www.readbyqxmd.com/read/29050317/microrna-542-3p-inhibits-oral-squamous-cell-carcinoma-progression-by-inhibiting-ilk-tgf-%C3%AE-1-smad2-3-signaling
#1
Bin Qiao, Jing-Hua Cai, Alfred King-Yin Lam, Bao-Xia He
In this study, we investigated the effects of microRNA-542-3p (miR-542-3p) on ILK/TGF-β1/Smad2/3 signaling and oral squamous cell carcinoma (OSCC) progression. Levels of miR-542-3p were lower in OSCC tissues (n=108) than adjacent normal tissues, whereas levels of ILK, TGF-β1 and Smad2/3 were higher. Patients with undifferentiated tumors, advanced TNM stage and lymph node metastasis showed low miR-542-3p levels. This was accompanied by high ILK expression and poor survival. Dual luciferase reporter assays of SCC-9 cells showed that miR-542-3p inhibited ILK gene expression by binding to its 3'UTR at 233-240 bp...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048352/effects-of-short-term-probiotic-ingestion-on-immune-profiles-and-microbial-translocation-among-hiv-1-infected-vietnamese-children
#2
Azumi Ishizaki, Xiuqiong Bi, Lam Van Nguyen, Kazunori Matsuda, Hung Viet Pham, Chung Thi Thu Phan, Dung Thi Khanh Khu, Hiroshi Ichimura
Here, we investigated the effects of the probiotic strain Lactobacillus casei Shirota (LcS) on immune profiles and intestinal microbial translocation among children infected with human immunodeficiency virus (HIV). This prospective study included 60 HIV-infected children-including 31 without antiretroviral therapy (ART) (HIV(+)) and 29 who received ART for a median of 3.5 years (ART(+)) and 20 children without HIV infection (HIV(-)). Participants were recruited in Vietnam. All children were given fermented milk containing LcS (6...
October 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29047964/laboratory-demonstration-of-a-cryogenic-deformable-mirror-for-wavefront-correction-of-space-borne-infrared-telescopes
#3
Aoi Takahashi, Keigo Enya, Kanae Haze, Hirokazu Kataza, Takayuki Kotani, Hideo Matsuhara, Tomohiro Kamiya, Tomoyasu Yamamuro, Paul Bierden, Steven Cornelissen, Charlie Lam, Michael Feinberg
This paper demonstrates a cryogenic deformable mirror (DM) with 1020 actuators based on micro-electrical mechanical systems (MEMS) technology. Cryogenic space-borne infrared telescopes can experience a wavefront error due to a figure error of their mirror surface, which makes the imaging performance worse. For on-orbit wavefront correction as one solution, we developed a MEMS-processed electro-static DM with a special surrounding structure for use under the cryogenic temperature. We conducted a laboratory demonstration of its operation in three cooling cycles between 5 K and 295 K...
August 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047228/organoiridium-photosensitizers-induce-specific-oxidative-attack-on-proteins-within-cancer-cells
#4
Pingyu Zhang, Cookson K C Chiu, Huaiyi Huang, Yuko P Y Lam, Abraha Habtemariam, Thomas Malcomson, Martin J Paterson, Guy J Clarkson, Peter B O'Connor, Hui Chao, Peter J Sadler
Strongly luminescent iridium(III) complexes, [Ir(C,N)2 (S,S)](+) (1) and [Ir(C,N)2 (O,O)] (2), containing C,N (phenylquinoline), O,O (diketonate), or S,S (dithione) chelating ligands, have been characterized by X-ray crystallography and DFT calculations. Their long phosphorescence lifetimes in living cancer cells give rise to high quantum yields for the generation of (1) O2 , with large 2-photon absorption cross-sections. 2 is nontoxic to cells, but potently cytotoxic to cancer cells upon brief irradiation with low doses of visible light, and potent at sub-micromolar doses towards 3D multicellular tumor spheroids with 2-photon red light...
October 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29047177/selected-hepatoprotective-herbal-medicines-evidence-from-ethnomedicinal-applications-animal-models-and-possible-mechanism-of-actions
#5
REVIEW
Muhammad Ali, Tariq Khan, Kaneez Fatima, Qurat Ul Ain Ali, Muhammad Ovais, Ali Talha Khalil, Ikram Ullah, Abida Raza, Zabta Khan Shinwari, Muhammad Idrees
Insight into the hepatoprotective effects of medicinally important plants is important, both for physicians and researchers. Main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants: Silybum marianum (L.) Gaertn., Glycyrrhiza glabra, Phyllanthus amarus Schumach...
October 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29047125/how-to-describe-your-data-the-devil-is-in-the-distribution
#6
S W Choi, D M H Lam
No abstract text is available yet for this article.
November 2017: Anaesthesia
https://www.readbyqxmd.com/read/29045533/liposuction-augmentation-mammaplasty
#7
Ryan Harris, Peter Raphael, Scott W Harris
Background: The female breast loses superior fullness and becomes more ptotic over time. Women often present to their plastic surgeon requesting reversal of this evolution. While liposuction alone has been proven to lift the breast, no solution combining augmentation and liposuction has been reported. Objectives: Herein, we introduce a technique called liposuction-augmentation mammaplasty (LAM) that can achieve "scarless" lifting or simply volume equalization prior to inserting same-sized implants...
October 16, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29044932/right-heart-dysfunction-and-failure-in-heart-failure-with-preserved-ejection-fraction-mechanisms-and-management-position-statement-on-behalf-of-the-heart-failure-association-of-the-european-society-of-cardiology
#8
REVIEW
Thomas M Gorter, Dirk J van Veldhuisen, Johann Bauersachs, Barry A Borlaug, Jelena Celutkiene, Andrew J S Coats, Marisa G Crespo-Leiro, Marco Guazzi, Veli-Pekka Harjola, Stephane Heymans, Loreena Hill, Mitja Lainscak, Carolyn S P Lam, Lars H Lund, Alexander R Lyon, Alexandre Mebazaa, Christian Mueller, Walter J Paulus, Burkert Pieske, Massimo F Piepoli, Frank Ruschitzka, Frans H Rutten, Petar M Seferovic, Scott D Solomon, Sanjiv J Shah, Filippos Triposkiadis, Rolf Wachter, Carsten Tschöpe, Rudolf A de Boer
There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients...
October 16, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29044875/consecutive-cases-of-thyrolipomatosis-and-thymolipoma-a-case-report
#9
Anne Stanaway, Tracey Lam
No abstract text is available yet for this article.
October 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29044736/multiscale-humidity-visualization-by-environmentally-sensitive-fluorescent-molecular-rotors
#10
Yanhua Cheng, Jianguo Wang, Zijie Qiu, Xiaoyan Zheng, Nelson L C Leung, Jacky W Y Lam, Ben Zhong Tang
Building humidity sensors possessing the features of diverse-configuration compatibility, and capability of measurement of spatial and temporal humidity gradients is of great interest for highly integrated electronics and wearable monitoring systems. Herein, a visual sensing approach based on fluorescent imaging is presented, by assembling aggregation-induced-emission (AIE)-active molecular rotors into a moisture-captured network; the resulting AIE humidity sensors are compatible with diverse applications, having tunable geometries and desirable architectures...
October 16, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29042670/from-est-to-novel-spider-silk-gene-identification-for-production-of-spidroin-based-biomaterials
#11
Weidong Huang, Yan Zhang, Yifan Chen, Yin Wang, Wensu Yuan, Ning Zhang, Toong Jin Lam, Zhiyuan Gong, Daiwen Yang, Zhi Lin
A cDNA library from a pool of all the seven silk glands from a tropical spider species was constructed. More than 1000 expressed sequence tag (EST) clones were created. Almost 65% of the EST clones were identified and around 50% were annotated. The cellular and functional distribution of the EST clones indicated high protein synthesis activity in spider silk glands. Novel clones with repetitive amino acid sequences, which is one of the most important characteristics of spider silk genes, were isolated. One of these clones, namely TuSp2 in current research, contains two almost identical fragments with one short C-terminal domain...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042472/technical-advances-in-image-guidance-of-radionuclide-therapy
#12
Casper Beijst, Britt Kunnen, Marnix Lam, Hugo de Jong
Internal radiation therapy with radionuclides (i.e. radionuclide therapy) owes its success to the many advantages over other, more conventional treatment options. One distinct advantage of radionuclide therapies is the potential to use (part of) the emitted radiation for imaging of the radionuclide distribution. The combination of diagnostic and therapeutic properties in a set of matched radiopharmaceuticals (sometimes combined in single a radiopharmaceutical) is often referred to as theranostics and allows accurate diagnostic imaging prior to therapy...
October 17, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29042313/the-hypothetical-protein-p47-of-clostridium-botulinum-e1-strain-beluga-has-a-structural-topology-similar-to-bactericidal-permeability-increasing-protein
#13
Kwok-Ho Lam, Ruifeng Qi, Shun Liu, Amelie Kroh, Guorui Yao, Kay Perry, Andreas Rummel, Rongsheng Jin
Botulinum neurotoxins (BoNTs) are causative agents of the life-threatening disease botulism. They are naturally produced by species of the bacteria Clostridium botulinum as stable and non-covalent complexes, in which the BoNT molecule is assembled with several auxiliary non-toxic proteins. Some BoNT serotypes, represented by the well-studied BoNT serotype A (BoNT/A), are produced by Clostridium strains that carry the ha gene cluster, which encodes four neurotoxin-associated proteins (NTNHA, HA17, HA33, and HA70) that play an important role to deliver and protect BoNTs in the gastrointestinal tract during oral intoxication...
October 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29042255/comparison-of-raw264-7-human-whole-blood-and-pbmc-assays-to-screen-for-immunomodulators
#14
Ingrid Elisia, Han Bee Pae, Vivian Lam, Rachel Cederberg, Elyse Hofs, Gerald Krystal
The RAW264.7 mouse macrophage cell line is used extensively to carry out in vitro screens for immunomodulators. Compounds that are effective at reducing the expression of pro-inflammatory cytokines or nitric oxide (NO) from lipopolysaccharide (LPS)-stimulated RAW264.7 cells are often considered candidate anti-inflammatory agents for humans. There is, however, very little data on the reliability of this screen to identify bona fide human immunomodulators. We compared the efficacy of 37 purported immunomodulators to modulate LPS or E...
October 14, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29041714/real-time-in-situ-study-of-femtosecond-laser-induced-periodic-structures-on-metals-by-linear-and-nonlinear-optics
#15
Jihua Zhang, Yizhuo He, Billy Lam, Chunlei Guo
Femtosecond-laser surface structuring on metals is investigated in real time by both fundamental and second harmonic generation (SHG) signals. The onset of surface modification and its progress can be monitored by both the fundamental and SHG probes. However, the dynamics of femtosecond-laser-induced periodic surface structures (FLIPSSs) formation can only be revealed by SHG but not fundamental because of the higher sensitivity of SHG to structural geometry on metal. Our technique provides a simple and effective way to monitor the surface modification and FLIPSS formation thresholds and allows us to obtain the optimal FLIPSS for SHG enhancement...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29040589/corifollitropin-alfa-followed-by-highly-purified-hmg-versus-recombinant-fsh-in-young-poor-ovarian-responders-a-multicentre-randomized-controlled-clinical-trial
#16
Panagiotis Drakopoulos, Thi Ngoc Lan Vuong, Ngoc Anh Vu Ho, Alberto Vaiarelli, Manh Tuong Ho, Christophe Blockeel, Michel Camus, Anh Tuan Lam, Arne van de Vijver, Peter Humaidan, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: Does administration of corifollitropin alfa followed by highly purified (hp) HMG result in higher ongoing pregnancy rates compared with daily recombinant FSH (rFSH) in young poor responders? SUMMARY ANSWER: Corifollitropin alfa followed by hp-HMG does not increase ongoing pregnancy rates compared with rFSH in young poor responders, although more supernumerary cryopreserved embryos were obtained with corifollitropin alfa and hp-HMG. WHAT IS KNOWN ALREADY: Poor ovarian response remains one of the main therapeutic challenges in women undergoing ovarian stimulation, given that very low live birth rates of 6% have been reported in this particular group of infertile patients...
September 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040211/altered-macular-microvasculature-in-mild-cognitive-impairment-and-alzheimer-disease
#17
Hong Jiang, Yantao Wei, Yingying Shi, Clinton B Wright, Xiaoyan Sun, Giovanni Gregori, Fang Zheng, Elizabeth A Vanner, Byron L Lam, Tatjana Rundek, Jianhua Wang
BACKGROUND: The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). METHODS: Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP)...
October 16, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29040205/spleen-preserving-distal-pancreatectomy-in-trauma
#18
Morgan Schellenberg, Kenji Inaba, Vincent Cheng, James M Bardes, Lydia Lam, Elizabeth Benjamin, Kazuhide Matsushima, Demetrios Demetriades
BACKGROUND: Traumatic injuries to the distal pancreas are infrequent. Universally accepted recommendations about the need for routine splenectomy with distal pancreatectomy do not exist. The aims of this study were to compare outcomes after distal pancreatectomy and splenectomy vs spleen-preserving distal pancreatectomy, and to define the appropriate patient population for splenic preservation. METHODS: All patients who underwent distal pancreatectomy (01/01/2007-12/31/2014) were identified from the NTDB...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29038204/do-we-need-a-patient-centered-target-for-systolic-blood-pressure-in-hypertensive-patients-with-type-2-diabetes-mellitus
#19
Eric Yuk Fai Wan, Esther Yee Tak Yu, Colman Siu Cheung Fung, Weng Yee Chin, Daniel Yee Tak Fong, Anca Ka Chun Chan, Cindy Lo Kuen Lam
The current trend on diabetes mellitus management advocates replacing the paradigm from a uniform to an individualized patient-centered systolic blood pressure (SBP), but there is no consensus on the achieved treatment goals of SBP level. The study aimed at evaluating the association between SBP and the risk of cardiovascular diseases (CVD) and all-cause mortality for diabetic patients to identify patient-centered treatment targets. A retrospective study was conducted on 95 086 Chinese adult primary care patients with type 2 diabetes mellitus and hypertension...
October 16, 2017: Hypertension
https://www.readbyqxmd.com/read/29037258/transplantation-of-isl1-cardiac-progenitor-cells-in-small-intestinal-submucosa-improves-infarcted-heart-function
#20
Lingjun Wang, Elizabeth M Meier, Shuo Tian, Ienglam Lei, Liu Liu, Shaoxiang Xian, Mai T Lam, Zhong Wang
BACKGROUND: Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. METHODS: In this study, we seeded Isl1(+) embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1(+) CPCs and the biocompatibility of SIS-ECM with these cells...
October 16, 2017: Stem Cell Research & Therapy
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