keyword
https://read.qxmd.com/read/38546147/increased-matrix-metalloproteinase-2-in-ligamentum-flavum-hypertrophy-and-the-regulation-of-mmp-2-timps-by-elastin-derived-peptides
#1
JOURNAL ARTICLE
Wen-Hai Zhuo, Hwee Weng Dennis Hey, Wing Moon Raymond Lam, Xiaoyun Chloe Chan, Loo Hoey Lit, Yong Soon Chiong, Hee-Kit Wong
The study aimed to examine matrix metalloproteinase-2 (MMP-2) expression in a rat ligamentum flavum (LF) hypertrophy model in vivo, and the effect of elastin-derived peptides (EDPs) on MMP-2 and tissue inhibitors of metalloproteinases (TIMPs) in rat LF cells in vitro. Surgical destabilization was performed at the rat spinal L3/4 level to induce increased mechanical stress. Rats were killed at 6- and 12-weeks postsurgery for histological staining, immunohistochemical staining, RT-qPCR and western blot. 100 µg/mL EDPs were applied to isolated normal rat LF cells, with or without pretreatment of elastin receptor complex (ERC) inhibitors, to assess the expression of MMP-2, TIMP-1, and TIMP-2...
March 28, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38543987/hardware-schemes-for-smarter-indoor-robotics-to-prevent-the-backing-crash-framework-using-field-programmable-gate-array-based-multi-robots
#2
JOURNAL ARTICLE
Mudasar Basha, Munuswamy Siva Kumar, Mangali Chinna Chinnaiah, Siew-Kei Lam, Thambipillai Srikanthan, Janardhan Narambhatla, Hari Krishna Dodde, Sanjay Dubey
The use of smart indoor robotics services is gradually increasing in real-time scenarios. This paper presents a versatile approach to multi-robot backing crash prevention in indoor environments, using hardware schemes to achieve greater competence. Here, sensor fusion was initially used to analyze the state of multi-robots and their orientation within a static or dynamic scenario. The proposed novel hardware scheme-based framework integrates both static and dynamic scenarios for the execution of backing crash prevention...
March 7, 2024: Sensors
https://read.qxmd.com/read/38543928/design-and-preclinical-evaluation-of-a-nanoparticle-vaccine-against-respiratory-syncytial-virus-based-on-the-attachment-protein-g
#3
JOURNAL ARTICLE
Richard Voorzaat, Freek Cox, Daan van Overveld, Lam Le, Lisanne Tettero, Joost Vaneman, Mark J G Bakkers, Johannes P M Langedijk
Human respiratory syncytial virus (RSV) poses a significant human health threat, particularly to infants and the elderly. While efficacious vaccines based on the F protein have recently received market authorization, uncertainties remain regarding the future need for vaccine updates to counteract potential viral drift. The attachment protein G has long been ignored as a vaccine target due to perceived non-essentiality and ineffective neutralization on immortalized cells. Here, we show strong G-based neutralization in fully differentiated human airway epithelial cell (hAEC) cultures that is comparable to F-based neutralization...
March 12, 2024: Vaccines
https://read.qxmd.com/read/38543689/preclinical-antiviral-and-safety-profiling-of-the-hbv-rna-destabilizer-ab-161
#4
JOURNAL ARTICLE
Angela M Lam, Ravi R Dugyala, Muhammed Sheraz, Fei Liu, Emily P Thi, Ingrid E Graves, Andrea Cuconati, Holly Micolochick Steuer, Andrzej Ardzinski, Nathan Overholt, Jeremy D Mason, Dimitar Gotchev, Andrew G Cole, Troy O Harasym, Michael J Sofia
HBV RNA destabilizers are a class of small-molecule compounds that target the noncanonical poly(A) RNA polymerases PAPD5 and PAPD7, resulting in HBV RNA degradation and the suppression of viral proteins including the hepatitis B surface antigen (HBsAg). AB-161 is a next-generation HBV RNA destabilizer with potent antiviral activity, inhibiting HBsAg expressed from cccDNA and integrated HBV DNA in HBV cell-based models. AB-161 exhibits broad HBV genotype coverage, maintains activity against variants resistant to nucleoside analogs, and shows additive effects on HBV replication when combined with other classes of HBV inhibitors...
February 21, 2024: Viruses
https://read.qxmd.com/read/38543016/phytochemical-profiling-by-uhplc-q-tof-ms-and-chemopreventive-effect-of-aqueous-extract-of-moringa-oleifera-leaves-and-benzyl-isothiocyanate-on-murine-mammary-carcinogenesis
#5
JOURNAL ARTICLE
Juan Pedro Rojas-Armas, Miriam Palomino-Pacheco, Jorge Luis Arroyo-Acevedo, José Manuel Ortiz-Sánchez, Hugo Jesús Justil-Guerrero, Jaime Teodocio Martínez-Heredia, Américo Castro-Luna, Crescencio Rodríguez Flores, Aldo Javier Guzmán Duxtan
Moringa oleifera Lam, commonly known as moringa, is a plant widely used both as a human food and for medicinal purposes around the world. This research aimed to evaluate the efficacy of the aqueous extract of Moringa oleifera leaves (MoAE) and benzyl isothiocyanate (BIT) in rats with induced breast cancer. Cancer was induced with 7,12-dimethylbenz[a]anthracene (DMBA) at a dose of 60 mg/kg by orogastric gavage once only. Forty-eight rats were randomly assigned to eight groups, each consisting of six individuals...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38539871/phytonutritional-composition-and-antioxidant-properties-of-southern-african-purple-fleshed-sweet-potato-ipomoea-batatas-l-lam-storage-roots
#6
JOURNAL ARTICLE
Ayanda Ngcobo, Sephora Mutombo Mianda, Faith Seke, Laurie M Sunette, Dharini Sivakumar
Purple sweet potatoes ( Ipomoea batatas (L.) genotype) in Southern Africa have a phytonutritional composition and antioxidant properties that can increase incomes and improve nutrition. This study compared the phytonutrient composition and antioxidant properties of four purple-colour sweet potato genotypes (local Purple-purple, '2019-1-1', and USA genotypes, '08-21P' and '16-283P'). These purple sweet potato genotypes were characterised by UPLC/QTOF/MS and 16 phenolic compounds were identified. Purple-purple (very dark purple) showed the highest concentration of cyanidins and peonidin derivatives...
March 11, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539858/characterization-of-azorean-plant-leaves-for-sustainable-valorization-and-future-advanced-applications-in-the-food-cosmetic-and-pharmaceutical-industries
#7
JOURNAL ARTICLE
Jorge Gomes Lopes Barros, Raquel Fernandes, Ana Abraão, Rui Dias Costa, Alfredo Aires, Irene Gouvinhas, Daniel Granato, Ana Novo Barros
The historical use of plants as sources of natural compounds has persisted over time. Increasing the intake of bioactive substances shows significant potential for promoting overall well-being and health. This study delves into the pigments, phenolic composition, and profile, along with antioxidant properties, of leaf extracts rich in bioactives from plants in the Azores region, contributing to sustainable primary food production. Analyses encompassed chlorophylls, carotenoids, total phenols, ortho -diphenols, and flavonoids, as well as antioxidant capacity assessment, polyphenolic profiling, and quantification...
March 6, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539335/pediatric-patients-with-osteomyelitis-and-or-septic-joint-undergoing-surgical-debridement-have-equivalent-short-term-outcomes-with-or-without-preoperative-mri
#8
JOURNAL ARTICLE
E Graham Englert, Collin L Braithwaite, Maria E Aguirre-Flores, Aaron W Lam, Mohamed Sarraj, Abigail Kumagai, E Dimitra Bednar, Adam M Gordon, Ibrahim Salama, Jacob Keeley, Indu Pathak, Waleed Kishta, Ahmed M Thabet, Amr Abdelgawad, Ehab Saleh
The purpose of this study was to determine if short-term outcomes differed for pediatric patients with suspected musculoskeletal infection with or without a preoperative MRI. This was a multicenter, retrospective review of patients aged 0-16 years who presented with atraumatic extremity pain, underwent irrigation and debridement (I&D), and received at least one preoperative or postoperative MRI over a 10-year period. Primary outcomes were time to OR, total I&Ds, readmission rate, time from OR to discharge, and total number of MRIs...
March 2, 2024: Children
https://read.qxmd.com/read/38539280/executive-function-perceived-stress-and-eating-behaviours-among-chinese-young-adults
#9
JOURNAL ARTICLE
Meijun Chen, Wendy Wing Tak Lam, Jiehu Yuan, Meihong Dong, Lin Yang, Derwin King Chung Chan, Qiuyan Liao
Young adults in a transitional period may experience more stress and, hence, suffer from an increased risk of unhealthy eating. Executive function (EF) involves not only inhibitory control and mental flexibility (the 'cool' facet) to facilitate resistance to immediate temptations, but also affective decision making (the 'hot' facet) that helps to regulate emotional eating. The effects of different facets of EF and their interactions with perceived stress on eating behaviours remained underexplored. In this study, 594 young adults in their graduation year of post-secondary education were included...
March 27, 2024: Stress and Health: Journal of the International Society for the Investigation of Stress
https://read.qxmd.com/read/38539253/liver-specific-adiponectin-gene-therapy-suppresses-microglial-nlrp3-inflammasome-activation-for-treating-alzheimer-s-disease
#10
JOURNAL ARTICLE
Roy Chun-Laam Ng, Min Jian, Oscar Ka-Fai Ma, Ariya Weiman Xiang, Myriam Bunting, Jason Shing-Cheong Kwan, Curtis Wai-Kin Wong, Leung-Wah Yick, Sookja Kim Chung, Karen Siu-Ling Lam, Ian E Alexander, Aimin Xu, Koon-Ho Chan
Adiponectin (APN) is an adipokine which predominantly expresses in adipocytes with neuroprotective and anti-inflammatory effects. We have recently indicated that circulatory trimeric APN can enter the brain by crossing the blood-brain barrier (BBB) and modulate microglia-mediated neuroinflammation. Here, we found that the microglial NLR family pyrin domain containing 3 (NLRP3)-inflammasome activation was exacerbated in APN-/- 5xFAD mice in age-dependent manner. The focus of this study was to develop a new and tractable therapeutic approach for treating Alzheimer's disease (AD)-related pathology in 5xFAD mice using peripheral APN gene therapy...
March 27, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38538660/phylogenomics-of-tetraopes-longhorn-beetles-unravels-their-evolutionary-history-and-biogeographic-origins
#11
JOURNAL ARTICLE
Nayeli Gutiérrez-Trejo, Matthew H Van Dam, Athena W Lam, Gonzalo Martínez-Herrera, Felipe A Noguera, Thomas Weissling, Jessica L Ware, Víctor H Toledo-Hernández, Frederick W Skillman, Brian D Farrell, Oscar Pérez-Flores, Lorenzo Prendini, James M Carpenter
Tetraopes longhorn beetles are known for their resistance to milkweed plant toxins and their coevolutionary dynamics with milkweed plants (Asclepias). This association is considered a textbook example of coevolution, in which each species of Tetraopes is specialized to feed on one or a few species of Asclepias. A major challenge to investigating coevolutionary hypotheses and conducting molecular ecology studies lies in the limited understanding of the evolutionary history and biogeographical patterns of Tetraopes...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38538436/billroth-ii-modified-with-hinged-anti-peristaltic-afferent-loop-versus-roux-en-y-reconstruction-after-distal-gastrectomy-for-gastric-cancer-a-propensity-score-match-analysis
#12
JOURNAL ARTICLE
Dang Quang Thong, Ho Le Minh Quoc, Tran Quang Dat, Nguyen Viet Hai, Doan Thuy Nguyen, Nguyen Vu Tuan Anh, Nguyen Lam Vuong, Nguyen Hoang Bac, Vo Duy Long
BACKGROUND: This study aimed to evaluate the effectiveness of modified Billroth-II with a hinged anti-peristaltic afferent loop by comparing it with the Roux-en-Y method. METHODS: We retrospectively analyzed 344 patients with gastric cancer who underwent distal gastrectomy between 2016 and 2021. Propensity score matching was conducted to balance baseline characteristics. RESULTS: After propensity score matching, there were 117 patients in each group...
March 26, 2024: Surgery
https://read.qxmd.com/read/38537362/climatic-oceanic-freshwater-and-local-environmental-drivers-of-new-zealand-estuarine-macroinvertebrates
#13
JOURNAL ARTICLE
Orlando Lam-Gordillo, Judi E Hewitt, Emily J Douglas, Bruce D Dudley, Steven J Holmes, Sarah Hailes, Kelly Carter, Barry Greenfield, Tarn Drylie, Andrew M Lohrer
Understanding the responses of organisms to different environmental drivers is critical for improving ecosystem management and conservation. Estuarine ecosystems are under pressure from multiple anthropogenic stressors (e.g. increasing sediment and nutrient loads, pollution, climate change) that are affecting the functions and services these ecosystems provide. Here, we used long-term estuarine benthic invertebrate monitoring data (∼30 year time-series) to evaluate the responses of macrobenthic invertebrate communities and indicator species to climatic, oceanic, freshwater, and local environmental drivers in New Zealand estuaries...
March 21, 2024: Marine Environmental Research
https://read.qxmd.com/read/38536887/endothelial-and-inflammatory-pathophysiology-in-dengue-shock-new-insights-from-a-prospective-cohort-study-in-vietnam
#14
JOURNAL ARTICLE
Angela McBride, Huynh Thi Le Duyen, Nguyen Lam Vuong, Phan Vinh Tho, Luong Thi Hue Tai, Nguyen Thanh Phong, Nguyen Thanh Ngoc, Lam Minh Yen, Phung Tran Huy Nhat, Tran Thuy Vi, Martin J Llewelyn, Louise Thwaites, Nguyen Van Hao, Sophie Yacoub
Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536198/fulbright-as-opportunity-for-u-s-nursing-educators-and-international-nursing-schools
#15
JOURNAL ARTICLE
Lynda Boyer-Chu, Thu H T Huynh, Ngoan T N Nguyen, Tuyen K T Bui, Giang H L Ngo, Dao T Vu, Hieu H T Lam, Uyen B T Truong
BACKGROUND: Nursing education across the globe is rapidly evolving in terms of curricular expectations and professional preparation. While there is a plethora of curricular resources and graduate programs in the United States, in some countries, these resources are limited. METHODS: The Fulbright Specialist program, the application process, and challenges as well as the benefits of the role are described. The deliverables by the Fulbright Specialist, e.g. demonstrating classroom pedagogical methods, providing access to an online doctoral program, and explaining publication strategies, are noted...
March 25, 2024: Journal of Nursing Education
https://read.qxmd.com/read/38536153/prognostic-models-for-mortality-and-morbidity-in-heart-failure-with-preserved-ejection-fraction
#16
JOURNAL ARTICLE
Kirsty McDowell, Toru Kondo, Atefeh Talebi, Ken Teh, Erasmus Bachus, Rudolf A de Boer, Ross T Campbell, Brian Claggett, Ashkay S Desai, Kieran F Docherty, Adrian F Hernandez, Silvio E Inzucchi, Mikhail N Kosiborod, Carolyn S P Lam, Felipe Martinez, Joanne Simpson, Muthiah Vaduganathan, Pardeep S Jhund, Scott D Solomon, John J V McMurray
IMPORTANCE: Accurate risk prediction of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) may help clinicians risk stratify and inform care decisions. OBJECTIVE: To develop and validate a novel prediction model for clinical outcomes in patients with HFpEF using routinely collected variables and to compare it with a biomarker-driven approach. DESIGN, SETTING, AND PARTICIPANTS: Data were used from the Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure (DELIVER) trial to derive the prediction model, and data from the Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction (PARAGON-HF) and the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-PRESERVE) trials were used to validate it...
March 27, 2024: JAMA Cardiology
https://read.qxmd.com/read/38536017/effects-of-empagliflozin-on-liver-fat-in-metabolic-dysfunction-associated-steatotic-liver-disease-patients-without-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#17
JOURNAL ARTICLE
Ka Shing Cheung, Ho Yu Ng, Rex Wan Hin Hui, Lok Ka Lam, Lung Yi Mak, Yuen Chi Ho, Jing Tong Tan, Esther W Chan, Wai Kay Seto, Man Fung Yuen, Wai K Leung
BACKGROUND AND AIMS: We investigated whether empagliflozin reduces hepatic steatosis in metabolic-dysfunction associated steatotic liver disease (MASLD) patients without diabetes mellitus (DM). APPROACH AND RESULTS: This was an investigator-initiated, double-blind, randomized, placebo-controlled trial recruiting adult subjects from the community. Eligible subjects without DM (fasting plasma glucose <7 mmol/L and HbA1c <6.5%) who had magnetic resonance imaging-proton density fat fraction [MRI-PDFF] ≥5% were randomly allocated to receive empagliflozin 10 mg daily or placebo (1:1 ratio) for 52 weeks (end of treatment, EOT)...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38535617/identifying-drivers-of-cost-in-pediatric-liver-transplantation
#18
JOURNAL ARTICLE
Divya Sabapathy, Kathleen Hosek, Fong W Lam, Moreshwar S Desai, Eric Williams, John Goss, Jean L Raphael, Michelle A Lopez
BACKGROUND & AIMS: Understanding the economics of pediatric liver transplantation (LT) is central to high-value care initiatives. We examined cost and resource utilization in pediatric LT nationally to identify drivers of cost and hospital factors associated with greater total cost of care. APPROACH & RESULTS: We reviewed 3295 children (<21 y) receiving a LT from 2010-2020 in the Pediatric Health Information System to study cost, both per LT and service-line, and associated mortality, complications and resource utilization...
March 27, 2024: Liver Transplantation
https://read.qxmd.com/read/38535127/expanded-newborn-screening-for-inborn-errors-of-metabolism-in-hong-kong-results-and-outcome-of-a-7-year-journey
#19
JOURNAL ARTICLE
Kiran Moti Belaramani, Toby Chun Hei Chan, Edgar Wai Lok Hau, Matthew Chun Wing Yeung, Anne Mei Kwun Kwok, Ivan Fai Man Lo, Terry Hiu Fung Law, Helen Wu, Sheila Suet Na Wong, Shirley Wai Lam, Gladys Ha Yin Ha, Toby Pui Yee Lau, Tsz Ki Wong, Venus Wai Ching Or, Rosanna Ming Sum Wong, Wong Lap Ming, Jasmine Chi Kwan Chow, Eric Kin Cheong Yau, Antony Fu, Josephine Shuk Ching Chong, Ho Chung Yau, Grace Wing Kit Poon, Kwok Leung Ng, Kwong Tat Chan, Yuen Yu Lam, Joannie Hui, Chloe Miu Mak, Cheuk Wing Fung
Newborn screening (NBS) is an important public health program that aims to identify pre-symptomatic healthy babies that will develop significant disease if left undiagnosed and untreated. The number of conditions being screened globally is expanding rapidly in parallel with advances in technology, diagnosis, and treatment availability for these conditions. In Hong Kong, NBS for inborn errors of metabolism (NBSIEM) began as a pilot program in October 2015 and was implemented to all birthing hospitals within the public healthcare system in phases, with completion in October 2020...
March 11, 2024: International Journal of Neonatal Screening
https://read.qxmd.com/read/38535053/a-web-based-dynamic-nomogram-to-predict-the-risk-of-methicillin-resistant-staphylococcal-infection-in-patients-with-pneumonia
#20
JOURNAL ARTICLE
Van Duong-Thi-Thanh, Binh Truong-Quang, Phu Tran-Nguyen-Trong, Mai Le-Phuong, Phu Truong-Thien, Dung Lam-Quoc, Thong Dang-Vu, Minh-Loi Nguyen, Vu Le-Thuong
The aim of this study was to create a dynamic web-based tool to predict the risks of methicillin-resistant Staphylococcus spp. (MRS) infection in patients with pneumonia. We conducted an observational study of patients with pneumonia at Cho Ray Hospital from March 2021 to March 2023. The Bayesian model averaging method and stepwise selection were applied to identify different sets of independent predictors. The final model was internally validated using the bootstrap method. We used receiver operator characteristic (ROC) curve, calibration, and decision curve analyses to assess the nomogram model's predictive performance...
March 16, 2024: Diagnostics
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