Gemma Serra-Bardenys, Enrique Blanco, Carmen Escudero-Iriarte, Queralt Serra-Camprubí, Jessica Querol, Laura Pascual-Reguant, Beatriz Morancho, Marta Escorihuela, Natalia Soledad Tissera, Anna Sabé, Luna Martín, Sandra Segura-Bayona, Gaetano Verde, Riccardo Aiese Cigliano, Alba Millanes-Romero, Celia Jerónimo, Joan Pau Cebrià-Costa, Paolo Nuciforo, Sara Simonetti, Cristina Viaplana, Rodrigo Dienstmann, Mafalda Oliveira, Vicente Peg, Travis H Stracker, Joaquín Arribas, Francesc Canals, Josep Villanueva, Luciano Di Croce, Antonio García de Herreros, Tian V Tian, Sandra Peiró
Oxidation of histone H3 at lysine 4 (H3K4ox) is catalyzed by lysyl oxidase homolog 2 (LOXL2). This histone modification is enriched in heterochromatin in triple-negative breast cancer (TNBC) cells and has been linked to the maintenance of compacted chromatin. However, the molecular mechanism underlying this maintenance is still unknown. Here, we show that LOXL2 interacts with RuvB-Like 1 (RUVBL1), RuvB-Like 2 (RUVBL2), Actin-like protein 6A (ACTL6A), and DNA methyltransferase 1associated protein 1 (DMAP1), a complex involved in the incorporation of the histone variant H2A...
March 7, 2024: FEBS Journal