Daheui Choi, Alan M Gonzalez-Suarez, Mihai G Dumbrava, Michael Medlyn, Jose M de Hoyos-Vega, Frank Cichocki, Jeffrey S Miller, Li Ding, Mojun Zhu, Gulnaz Stybayeva, Alexandre Gaspar-Maia, Daniel D Billadeau, Wen Wee Ma, Alexander Revzin
Patient-derived cancer organoids (PDOs) hold considerable promise for personalizing therapy selection and improving patient outcomes. However, it is challenging to generate PDOs in sufficient numbers to test therapies in standard culture platforms. This challenge is particularly acute for pancreatic ductal adenocarcinoma (PDAC) where most patients are diagnosed at an advanced stage with non-resectable tumors and where patient tissue is in the form of needle biopsies. Here the development and characterization of microfluidic devices for testing therapies using a limited amount of tissue or PDOs available from PDAC biopsies is described...
November 29, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)