keyword
MENU ▼
Read by QxMD icon Read
search

Glycogen availability

keyword
https://www.readbyqxmd.com/read/29668480/the-6th-rare-disease-south-eastern-europe-see-meeting-skopje-macedonia-november-11th-2017
#1
Zoran Gucev, Velibor Tasic, Momir Polenakovic
The sixth SEE meeting on rare diseases (RDs) was held in MASA the November 10th, 2017. A block of lectures on rare renal diseases started the meeting: nephrotic syndrome, Alport syndrome, atypical HUS, hypophosphatemic rickets, CAKUT were presented in all complexities. Their molecular and genetic mechanisms were discussed. The discovery of a dozen of newly genes in CAKUT, congenital overgrowth, spodilocostal dysplasia, precocious puberty has been done with collaboration of Macedonian and foreign researchers...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/29663142/do-we-need-a-cool-down-after-exercise-a-narrative-review-of-the-psychophysiological-effects-and-the-effects-on-performance-injuries-and-the-long-term-adaptive-response
#2
REVIEW
Bas Van Hooren, Jonathan M Peake
It is widely believed that an active cool-down is more effective for promoting post-exercise recovery than a passive cool-down involving no activity. However, research on this topic has never been synthesized and it therefore remains largely unknown whether this belief is correct. This review compares the effects of various types of active cool-downs with passive cool-downs on sports performance, injuries, long-term adaptive responses, and psychophysiological markers of post-exercise recovery. An active cool-down is largely ineffective with respect to enhancing same-day and next-day(s) sports performance, but some beneficial effects on next-day(s) performance have been reported...
April 16, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29595915/dual-treatment-with-a-fixed-ratio-of-glucagon-and-insulin-increases-the-therapeutic-window-of-insulin-in-diabetic-rats
#3
Christina Pedersen, Stephan D Bouman, Trine Porsgaard, Mette M Rosenkilde, Nikolaj K Roed
The current available insulin therapies decrease blood glucose but are associated with the risk of developing hypoglycemia. Glucagon is a counter regulatory hormone and we hypothesize that a fixed ratio of insulin and a long-acting glucagon-analogue can reduce the risk of hypoglycemia. To define an appropriate ratio we tested two fixed glucagon doses (3.5 and 10 nmol/kg) in combination with increasing doses of insulin in diabetic rats. We observed a plateau in blood glucose at 15.2 mmol/L with 10 nmol/kg of the glucagon-analogue...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29578387/identifying-natural-compounds-as-multi-target-directed-ligands-against-alzheimer-s-disease-an-in-silico-approach
#4
Pravin Ambure, Jyotsna Bhat, Tomasz Puzyn, Kunal Roy
Alzheimer's disease (AD) is a multi-factorial disease, which can be simply outlined as an irreversible and progressive neurodegenerative disorder with an unclear root cause. It is a major cause of dementia in old aged people. In the present study, utilizing the structural and biological activity information of ligands for five important and mostly studied vital targets (i.e., cyclin-dependant kinase 5, β-secretase, monoamine oxidase B, glycogen synthase kinase 3β, and acetylcholinesterase) that are believed to be effective against Alzheimer's disease, we have developed five classification models using linear discriminant analysis (LDA) technique...
March 26, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29576889/recent-development-and-gene-therapy-for-glycogen-storage-disease-type-ia
#5
Janice Y Chou, Goo-Young Kim, Jun-Ho Cho
Glycogen storage disease type Ia (GSD-Ia) is an autosomal recessive metabolic disorder caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) that is expressed primarily in the liver, kidney, and intestine. G6Pase-α catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate in the terminal step of gluconeogenesis and glycogenolysis, and is a key enzyme for endogenous glucose production. The active site of G6Pase-α is inside the endoplasmic reticulum (ER) lumen. For catalysis, the substrate G6P must be translocated from the cytoplasm into the ER lumen by a G6P transporter (G6PT)...
September 2017: Liver Research
https://www.readbyqxmd.com/read/29566022/influence-of-vegetable-diets-on-physiological-and-immune-responses-to-thermal-stress-in-senegalese-sole-solea-senegalensis
#6
Marta Conde-Sieira, Manuel Gesto, Sónia Batista, Fátima Linares, José L R Villanueva, Jesús M Míguez, José L Soengas, Luísa M P Valente
The substitution of fish resources as ingredients for aquafeeds by those based on vegetable sources is needed to ensure aquaculture sustainability in the future. It is known that Senegalese sole (Solea senegalensis) accepts high dietary content of plant ingredients without altering growth or flesh quality parameters. However, scarce information is available regarding the long-term impact of vegetable diets (combining the inclusion of both vegetable protein and oils) on the stress response and immunity of this fish species...
2018: PloS One
https://www.readbyqxmd.com/read/29565424/efficacy-safety-profile-and-immunogenicity-of-alglucosidase-alfa-produced-at-the-4-000-liter-scale-in-us-children-and-adolescents-with-pompe-disease-advance-a-phase-iv-open-label-prospective-study
#7
Si Houn Hahn, David Kronn, Nancy D Leslie, Loren D M Pena, Pranoot Tanpaiboon, Michael J Gambello, James B Gibson, Richard Hillman, David W Stockton, John W Day, Raymond Y Wang, Kristina An Haack, Raheel Shafi, Susan Sparks, Yang Zhao, Catherine Wilson, Priya S Kishnani
PurposePompe disease results from lysosomal acid α-glucosidase (GAA) deficiency and its associated glycogen accumulation and muscle damage. Alglucosidase alfa (recombinant human GAA (rhGAA)) received approval in 2006 as a treatment for Pompe disease at the 160 L production scale. In 2010, larger-scale rhGAA was approved for patients up to 8 years old without cardiomyopathy. NCT01526785 evaluated 4,000 L rhGAA efficacy/safety in US infantile- or late-onset Pompe disease (IOPD, LOPD) patients up to 1 year old transitioned from 160 L rhGAA...
March 22, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29535334/organ-specific-responses-during-brain-death-increased-aerobic-metabolism-in-the-liver-and-anaerobic-metabolism-with-decreased-perfusion-in-the-kidneys
#8
A C Van Erp, R A Rebolledo, D Hoeksma, N R Jespersen, P J Ottens, R Nørregaard, M Pedersen, C Laustsen, J G M Burgerhof, J C Wolters, J Ciapaite, H E Bøtker, H G D Leuvenink, B Jespersen
Hepatic and renal energy status prior to transplantation correlates with graft survival. However, effects of brain death (BD) on organ-specific energy status are largely unknown. We studied metabolism, perfusion, oxygen consumption, and mitochondrial function in the liver and kidneys following BD. BD was induced in mechanically-ventilated rats, inflating an epidurally-placed Fogarty-catheter, with sham-operated rats as controls. A 9.4T-preclinical MRI system measured hourly oxygen availability (BOLD-related R2*) and perfusion (T1-weighted)...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29523196/2-deoxy-2-18-fluoro-d-glucose-pet-ct-18fdg-pet-ct-may-not-be-a-viable-biomarker-in-pompe-disease
#9
U Plöckinger, V Prasad, A Ziagaki, N Tiling, A Poellinger
BACKGROUND: Pompe disease (PD) is an autosomal recessive, lysosomal storage disease due to a mutation of the acid α-glucosidase (GAA) gene. In adult patients, PD is characterized by slowly progressive limb-girdle and trunk myopathy and restrictive respiratory insufficiency. Enzyme replacement therapy (ERT) is available, improving or stabilizing muscle-function in some and slowing deterioration in other patients. Unfortunately, there is no biomarker available to indicate therapeutic efficacy and/or disease activity...
March 9, 2018: Human Genomics
https://www.readbyqxmd.com/read/29509141/-fanconi-bickel-syndrom-a-novel-genetic-disease-in-original-braunvieh
#10
S Joller, M Stettler, I Locher, M Dettwiler, F Seefried, M Meylan, C Drögemüller
This case report describes a new genetic disease of the Braunvieh breed in Switzerland. The bovine disorder also occurs in German Fleckvieh, and corresponds to human Fanconi-Bickel syndrome which is an inherited glycogen storage disease caused by mutations of the SLC2A2 gene encoding the glucose transporter GLUT2. This case report describes a single affected Original Braunvieh calf genotyped as homozygous for the FH2-associated SLC2A2 frame shift mutation. The clinical examination showed stunted growth, polyuria and polydipsia, as well as poor claw horn and coat quality...
March 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29498691/regulation-of-muscle-glycogen-metabolism-during-exercise-implications-for-endurance-performance-and-training-adaptations
#11
REVIEW
Mark A Hearris, Kelly M Hammond, J Marc Fell, James P Morton
Since the introduction of the muscle biopsy technique in the late 1960s, our understanding of the regulation of muscle glycogen storage and metabolism has advanced considerably. Muscle glycogenolysis and rates of carbohydrate (CHO) oxidation are affected by factors such as exercise intensity, duration, training status and substrate availability. Such changes to the global exercise stimulus exert regulatory effects on key enzymes and transport proteins via both hormonal control and local allosteric regulation...
March 2, 2018: Nutrients
https://www.readbyqxmd.com/read/29485701/brain-alpha-amylase-a-novel-energy-regulator-important-in-alzheimer-disease
#12
Elin Byman, Nina Schultz, Malin Fex, Malin Wennström
Reduced glucose metabolism and formation of polyglucosan bodies (PGB) are, beside amyloid beta plaques and neurofibrillary tangles, well-known pathological findings associated with Alzheimer's disease (AD). Since both glucose availability and PGB are regulated by enzymatic degradation of glycogen, we hypothesize that dysfunctional glycogen degradation is a critical event in AD progression. We therefore investigated whether alpha (α)-amylase, an enzyme known to efficiently degrade polysaccharides in the gastrointestinal tract, is expressed in the hippocampal CA1/subiculum and if the expression is altered in AD patients...
February 27, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29484381/sitagliptin-ameliorates-diabetic-nephropathy-by-blocking-tgf-%C3%AE-1-smad-signaling-pathway
#13
Dongdong Wang, Guanying Zhang, Xiao Chen, Tong Wei, Chenxu Liu, Chun Chen, Yinhan Gong, Qunli Wei
Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidney, but the efficacy of current strategies available for the prevention of DN remains unsatisfactory. The purpose of this study was to assess whether sitagliptin (SIT) has therapeutic potential for prevention of DN and to investigate its possible mechanism. The effects of SIT on DN were investigated in rats with type 2 diabetes mellitus (T2DM) and rat mesangial cells (MCs) induced by high glucose. T2DM rats were administered at a dose of 10 mg/kg SIT...
February 16, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29480468/biochemical-measurement-of-glycogen-method-to-investigate-the-ampk-glycogen-relationship
#14
Elite Possik, Arnim Pause
Glycogen is a main carbohydrate energy storage primarily found in fungi and animals. It is a glucose polymer that comprises α(1-4) glycosidic linkages attaching UDP-glucose molecules linearly and α(1-6) linkages branching glucose chains every 8-10 molecules to the main backbone chain. Glycogen synthase, branching enzyme, and glycogen phosphorylase are key enzymes involved in glycogen synthesis and degradation. These enzymes are tightly regulated by upstream kinases and phosphatases that respond to hormonal cues in order to coordinate storage and degradation and meet the cellular and organismal metabolic needs...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29473893/restoration-of-muscle-glycogen-and-functional-capacity-role-of-post-exercise-carbohydrate-and-protein-co-ingestion
#15
Abdullah F Alghannam, Javier T Gonzalez, James A Betts
The importance of post-exercise recovery nutrition has been well described in recent years, leading to its incorporation as an integral part of training regimes in both athletes and active individuals. Muscle glycogen depletion during an initial prolonged exercise bout is a main factor in the onset of fatigue and so the replenishment of glycogen stores may be important for recovery of functional capacity. Nevertheless, nutritional considerations for optimal short-term (3-6 h) recovery remain incompletely elucidated, particularly surrounding the precise amount of specific types of nutrients required...
February 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29467247/fat-body-glycogen-serves-as-a-metabolic-safeguard-for-the-maintenance-of-sugar-levels-in-drosophila
#16
Takayuki Yamada, Okiko Habara, Hitomi Kubo, Takashi Nishimura
Adapting to changes in food availability is a central challenge for survival. Glucose is an important resource for energy production, and therefore, many organisms synthesize and retain sugar storage molecules. In insects, glucose is stored in two different forms: the disaccharide trehalose and the branched polymer glycogen. Glycogen is synthesized and stored in several tissues, including in muscle and the fat body. Despite the important role of the fat body as a center for energy metabolism, the importance of its glycogen content remains unclear...
February 21, 2018: Development
https://www.readbyqxmd.com/read/29453741/fuel-for-the-work-required-a-theoretical-framework-for-carbohydrate-periodization-and-the-glycogen-threshold-hypothesis
#17
Samuel G Impey, Mark A Hearris, Kelly M Hammond, Jonathan D Bartlett, Julien Louis, Graeme L Close, James P Morton
Deliberately training with reduced carbohydrate (CHO) availability to enhance endurance-training-induced metabolic adaptations of skeletal muscle (i.e. the 'train low, compete high' paradigm) is a hot topic within sport nutrition. Train-low studies involve periodically training (e.g., 30-50% of training sessions) with reduced CHO availability, where train-low models include twice per day training, fasted training, post-exercise CHO restriction and 'sleep low, train low'. When compared with high CHO availability, data suggest that augmented cell signalling (73% of 11 studies), gene expression (75% of 12 studies) and training-induced increases in oxidative enzyme activity/protein content (78% of 9 studies) associated with 'train low' are especially apparent when training sessions are commenced within a specific range of muscle glycogen concentrations...
February 16, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29435782/insulin-resistance-in-glycogen-storage-disease-type-ia-linking-carbohydrates-and-mitochondria
#18
Alessandro Rossi, Margherita Ruoppolo, Pietro Formisano, Guglielmo Villani, Lucia Albano, Giovanna Gallo, Daniela Crisci, Augusta Moccia, Giancarlo Parenti, Pietro Strisciuglio, Daniela Melis
BACKGROUND: Glycogen storage disease type I (GSDI) is an inborn error of carbohydrate metabolism caused by mutations of either the G6PC gene (GSDIa) or the SLC37A4 gene (GSDIb). GSDIa patients are at higher risk of developing insulin-resistance (IR). Mitochondrial dysfunction has been implicated in the development of IR. Mitochondrial dysfunction can demonstrate abnormalities in plama acylcarnitines (ACs) and urine organic acids (UOA). The aim of the study was to investigate the presence of mitochondrial impairment in GSDI patients and its possible connection with IR...
February 12, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29434731/correlation-between-ppar-%C3%AE-methylation-level-in-peripheral-blood-and-inflammatory-factors-of-nafld-patients-with-dm
#19
Jianghua Ju, Qingxian Huang, Jing Sun, Yongcheng Jin, Wenjie Ma, Xiaohui Song, Huibo Sun, Wenhui Wang
The correlation between the methylation levels of peroxisome proliferator-activated receptor-α (PPAR-α) in the peripheral blood and the inflammatory factors associated with non-alcoholic fatty liver disease (NAFLD) patients with diabetes mellitus (DM) was investigated. Thirty-two samples of normal liver tissues (group N) and 35 samples of liver tissues from NAFLD patients with DM (group M) were used for the present study. The levels of alanine transaminase (ALT) and aspartate transaminase (AST) were measured using commercially available kits...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434550/select-skeletal-muscle-mrnas-related-to-exercise-adaptation-are-minimally-affected-by-different-pre-exercise-meals-that-differ-in-macronutrient-profile
#20
Pim Knuiman, Maria T E Hopman, Jeroen A Wouters, Marco Mensink
Background: Substantial research has been done on the impact of carbohydrate and fat availability on endurance exercise adaptation, though its role in the acute adaptive response to resistance exercise has yet to be fully characterized. Purpose: We aimed to assess the effects of a pre-resistance exercise isocaloric mixed meal containing different amounts of carbohydrates and fat, on post-resistance exercise gene expression associated with muscle adaptation. Methods: Thirteen young (age 21.2 ± 1.6 year), recreationally trained (VO2max 51...
2018: Frontiers in Physiology
keyword
keyword
105811
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"