Fan Zhai, Yun Wang, Hanna Li, Yuqian Wang, Xiaohui Zhu, Ying Kuo, Shuo Guan, Jiacheng Li, Shi Song, Qilong He, Jianting An, Xu Zhi, Ying Lian, Jin Huang, Rong Li, Jie Qiao, Liying Yan, Zhiqiang Yan
RESEARCH QUESTION: Can preimplantation genetic testing for structural rearrangement (PGT-SR) based on low-coverage next-generation sequencing (NGS) accurately discriminate between normal and carrier embryos of reciprocal translocation (RecT) and Robertsonian translocation (RobT)? DESIGN: A total of 109 couples with RecT or RobT were included in this study. The ages, bad obsteric histories (BOH), blood karyotype and IVF cycle information, including the number of cumulus-oocyte complexes, metaphase II oocytes, two pronuclei oocytes and blastocysts were recorded...
May 21, 2022: Reproductive Biomedicine Online