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https://www.readbyqxmd.com/read/29783727/prognosis-of-dermatitis-herpetiformis-patients-with-and-without-villous-atrophy-at-diagnosis
#1
Eriika Mansikka, Kaisa Hervonen, Katri Kaukinen, Pekka Collin, Heini Huhtala, Timo Reunala, Teea Salmi
Dermatitis herpetiformis (DH) is a cutaneous manifestation of coeliac disease. At diagnosis, the majority of patients have villous atrophy in the small bowel mucosa. The objective of this study was to investigate whether the presence or absence of villous atrophy at diagnosis affects the long-term prognosis of DH. Data were gathered from the patient records of 352 DH and 248 coeliac disease patients, and follow-up data via questionnaires from 181 DH and 128 coeliac disease patients on a gluten-free diet (GFD)...
May 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29781259/a-rare-case-of-pemphigus-herpetiformis-in-a-young-woman
#2
Rocco De Pasquale, Laura Scuderi, Rosario Caltabiano, Guido Russo, Dario F D'urso, Alessandra G Condorelli
No abstract text is available yet for this article.
May 16, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29763478/a-case-of-pustular-psoriasis-of-pregnancy-with-positive-maternal-fetal-outcomes
#3
Michelle Pitch, Kathryn Somers, Glynis Scott, Francisco Tausk, Mary G Mercurio
Pustular psoriasis of pregnancy (PPP), also known as impetigo herpetiformis, is a rare condition that affects women in the third trimester of pregnancy through the postpartum period. The relative infrequency of PPP presents both clinical and pathologic challenges in the diagnosis and management of this condition. We report a case of a woman who presented at 32 weeks' gestation with a generalized rash demonstrating clinicopathologic features consistent with PPP. Based on prior reports of adverse maternal-fetal outcomes in PPP, coordinated efforts from our patient's dermatologic and obstetric teams ensured positive outcomes for the patient and the neonate...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29757210/dermatitis-herpetiformis-a-common-extraintestinal-manifestation-of-coeliac-disease
#4
REVIEW
Timo Reunala, Teea T Salmi, Kaisa Hervonen, Katri Kaukinen, Pekka Collin
Dermatitis herpetiformis (DH) is a common extraintestinal manifestation of coeliac disease presenting with itchy papules and vesicles on the elbows, knees, and buttocks. Overt gastrointestinal symptoms are rare. Diagnosis of DH is easily confirmed by immunofluorescence biopsy showing pathognomonic granular immunoglobulin A (IgA) deposits in the papillary dermis. A valid hypothesis for the immunopathogenesis of DH is that it starts from latent or manifest coeliac disease in the gut and evolves into an immune complex deposition of high avidity IgA epidermal transglutaminase (TG3) antibodies, together with the TG3 enzyme, in the papillary dermis...
May 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29752728/a-retrospective-study-of-dermatitis-herpetiformis-from-an-immunobullous-disease-clinic-in-north-india
#5
Sanjeev Handa, Garima Dabas, Dipankar De, Rahul Mahajan, Debajyoti Chatterjee, Uma N Saika, Bishan D Radotra
BACKGROUND: Indian data on dermatitis herpetiformis (DH) is not available. The aim of this study was to investigate the demographic and clinicopathological characteristics of patients with DH and to study its association with other autoimmune diseases. METHODS: All data were collected from case record forms of patients registered in immunobullous disease clinic of our institute. The diagnosis was based on characteristic clinical and immuno/histopathological features...
May 11, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29664108/novel-association-of-a-papuloerythroderma-of-ofuji-phenotype-with-dermatitis-herpetiformis
#6
Harumi Ochi, Chia-Chun Ang
No abstract text is available yet for this article.
April 17, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29662290/extra-intestinal-manifestations-of-non-celiac-gluten-sensitivity-an-expanding-paradigm
#7
REVIEW
Giuseppe Losurdo, Mariabeatrice Principi, Andrea Iannone, Annacinzia Amoruso, Enzo Ierardi, Alfredo Di Leo, Michele Barone
Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most cases they are characterized by vague symptoms such as 'foggy mind', headache, fatigue, joint and muscle pain, leg or arm numbness even if more specific complaints have been described. NCGS has an immune-related background...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29577349/natural-history-and-clinical-detection-of-undiagnosed-coeliac-disease-in-a-north-american-community
#8
I A Hujoel, C T Van Dyke, T Brantner, J Larson, K S King, A Sharma, J A Murray, A Rubio-Tapia
BACKGROUND: Coeliac disease is a substantially underdiagnosed disorder, with clinical testing currently guided by case finding. AIM: To determine the presence of indications for diagnostic testing and frequency of clinical testing in undiagnosed coeliac disease. METHODS: This was a case-control study of adults without prior diagnosis of coeliac disease. Undiagnosed cases were identified through sequential serology, and unaffected age- and gender-matched controls were selected...
March 25, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29573491/generalized-pustular-psoriasis-a-review-and-update-on-treatment
#9
REVIEW
K M Hoegler, A M John, M Z Handler, R A Schwartz
Generalized pustular psoriasis (GPP) is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. The interleukin family and caspase recruitment domain family have been implicated in its pathogenesis. Other forms of pustular psoriasis include impetigo herpetiformis, palmoplantar pustular psoriasis, annular pustular psoriasis and acrodermatitis continua of Hallopeau...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29571943/sensitivity-of-transglutaminase-3-in-the-iga-aggregates-in-dermatitis-herpetiformis-skin-to-potassium-iodide
#10
Ted B Taylor, John J Zone
No abstract text is available yet for this article.
March 20, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29566927/blistering-diseases-in-the-mature-patient
#11
Ines Lakoš Jukić, Sandra Jerković Gulin, Branka Marinović
Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29538319/self-reported-fractures-in-dermatitis-herpetiformis-compared-to-coeliac-disease
#12
Camilla Pasternack, Eriika Mansikka, Katri Kaukinen, Kaisa Hervonen, Timo Reunala, Pekka Collin, Heini Huhtala, Ville M Mattila, Teea Salmi
Dermatitis herpetiformis (DH) is a cutaneous manifestation of coeliac disease. Increased bone fracture risk is known to associate with coeliac disease, but this has been only scantly studied in DH. In this study, self-reported fractures and fracture-associated factors in DH were investigated and compared to coeliac disease. Altogether, 222 DH patients and 129 coeliac disease-suffering controls were enrolled in this study. The Disease Related Questionnaire and the Gastrointestinal Symptom Rating Scale and Psychological General Well-Being questionnaires were mailed to participants; 45 out of 222 (20%) DH patients and 35 out of 129 (27%) of the coeliac disease controls had experienced at least one fracture ( p = 0...
March 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29531885/translational-chemistry-meets-gluten-related-disorders
#13
REVIEW
Karen M Lammers, Maria G Herrera, Veronica I Dodero
Gluten-related disorders are a complex group of diseases that involve the activation of the immune system triggered by the ingestion of gluten. Among these, celiac disease, with a prevalence of 1 %, is the most investigated, but recently, a new pathology, named nonceliac gluten sensitivity, was reported with a general prevalence of 7 %. Finally, there other less-prevalent gluten-related diseases such as wheat allergy, gluten ataxia, and dermatitis herpetiformis (with an overall prevalence of less than 0...
March 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29492350/scabies-surrepticius-scabies-masquerading-as-pityriasis-rosea
#14
Katherine M Stiff, Philip R Cohen
Scabies, a mite infestation caused by 'Sarcoptes scabiei', most commonly presents as pruritic linear burrows where the mite has invaded the skin. Scabies variant such as bullous, crusted, hidden, incognito, nodular and scalp-mimic the other conditions. In addition, atypical presentations of scabies can masquerade as dermatitis herpetiformis, ecchymosis, Langerhans cell histiocytosis, systemic lupus erythematosus, urticaria, and urticaria pigmentosa. A 59-year-old male presented with non-pruritic papulosquamous plaques on his chest, abdomen, and back resembling lesions of pityriasis rosea in morphology and distribution...
December 19, 2017: Curēus
https://www.readbyqxmd.com/read/29479654/pemphigus-group-overview-epidemiology-mortality-and-comorbidities
#15
REVIEW
Khalaf Kridin
Pemphigus forms a group of rare autoimmune bullous diseases that affect the skin and mucous membranes. This group has a chronic course leading to high morbidity and mortality. It is characterized by the production of pathogenic autoantibodies directed against different proteins of the desmosome, leading histologically to intraepidermal cleavage, and clinically to vesicles and erosions on the epithelium of the mucous membranes and/or the skin. The diagnosis of the subtype of pemphigus is based on clinical features, the level of histologic cleavage, and the identification of the antigens recognized by circulating autoantibodies by immunoserological analyses...
April 2018: Immunologic Research
https://www.readbyqxmd.com/read/29422292/autoinflammatory-keratinization-diseases-an-emerging-concept-encompassing-various-inflammatory-keratinization-disorders-of-the-skin
#16
REVIEW
Masashi Akiyama, Takuya Takeichi, John A McGrath, Kazumitsu Sugiura
Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC)...
May 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29417981/immunoexpression-of-iga-receptors-cd89-cd71-in-dermatitis-herpetiformis
#17
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Monika Bowszyc-Dmochowska, Elzbieta Kaczmarek, Marian Dmochowski
INTRODUCTION: The role of IgA receptors in dermatitis herpetiformis (DH) pathogenesis is still unknown. CD89 and CD71 may be associated with immune response during DH development. The purpose of this study was to perform semiquantitative analysis of simultaneous immunoexpression of CD89 and CD71 in DH and IgA/neutrophil-mediated non-DH dermatoses (IgAN) in relation to specific IgA autoantibodies/antibodies (tissue and epidermal transglutaminases, nonapeptides of gliadin - eTG/tTG/npG) as well neutrophil activation via the release of neutrophil elastase (NE)...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29368854/pemphigus-herpetiformis-resistant-to-first-line-therapy-a-rare-case-in-childhood
#18
Rosario Maggiore, Gianmaria Viglizzo, Corrado Occella, Dario Bleidl, Maria C Coccia, Francesca Manunza
No abstract text is available yet for this article.
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29333762/pemphigus-herpetiformis-with-autoantibodies-to-desmocollins-1-2-and-3
#19
Y E Tay, S S J Lee, Y L Lim
No abstract text is available yet for this article.
April 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29301808/skin-and-coeliac-disease-a-lot-to-think-about-a-case-series
#20
Sara O Vaz, Catarina Franco, Patrícia Santos, Raquel Amaral
Coeliac disease (CD) is an autoimmune disease, characterised by a permanent sensitivity to gluten. It is being progressively recognised as a multisystemic disease, with multiple extraintestinal manifestations. Skin conditions (eg, dermatitis herpetiformis) are an example of its manifestations; however, its underlying mechanisms are still not well understood. This article presents three cases of uncommon skin conditions in patients with a history of CD. Two of them concern linear IgA bullous dermatosis and erythema nodosum, which have been described in the literature as having potential associations with CD, though only a few cases were reported...
January 4, 2018: BMJ Case Reports
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