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https://www.readbyqxmd.com/read/28324040/cord-blood-adipocyte-fatty-acid-binding-protein-levels-correlate-with-gestational-age-and-birth-weight-in-neonates
#1
Kyoung Eun Joung, Sule Umit Cataltepe, Zoe Michael, Helen Christou, Christos S Mantzoros
Context: Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndrome in future life, but the underlying mechanisms are not fully elucidated. Adipocyte fatty acid binding protein, is an adipokine that has been implicated in modulation of insulin sensitivity and lipid metabolism. Higher plasma AFABP levels are associated with increased risk of metabolic syndrome and cardiovascular morbidity in adults. Alterations in AFABP levels during fetal growth have not been characterized...
January 31, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28319949/the-impact-of-kidney-development-on-the-life-course-a-consensus-document-for-action
#2
(no author information available yet)
Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future...
March 21, 2017: Nephron
https://www.readbyqxmd.com/read/28319175/preeclampsia-in-kidney-transplanted-women-outcomes-and-a-simple-prognostic-risk-score-system
#3
Guri Baardstu Majak, Anna Varberg Reisæter, Manuela Zucknick, Bjørg Lorentzen, Siri Vangen, Tore Henriksen, Trond Melbye Michelsen
Women pregnant following kidney transplantation are at high risk of preeclampsia. Identifying the effects of preeclampsia on pregnancy outcome and allograft function in kidney transplanted women, and predicting which women will require more targeted follow-up and possible therapeutic intervention, could improve both maternal and neonatal outcome. In this retrospective cohort study of all pregnancies following kidney transplantation in Norway between 1969 and 2013, we used medical records to identify clinical characteristics predictive of preeclampsia...
2017: PloS One
https://www.readbyqxmd.com/read/28318530/oxygen-targeting-in-infants-born-extremely-preterm-who-are-small-for-gestational-age-a-need-for-heightened-vigilance
#4
EDITORIAL
Barbara Schmidt, Robin K Whyte, Robin S Roberts
No abstract text is available yet for this article.
March 15, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28317131/association-of-shorter-height-with-increased-risk-of-ischaemic-placental-disease
#5
Kohei Ogawa, Naho Morisaki, Shigeru Saito, Shoji Sato, Takeo Fujiwara, Haruhiko Sago
BACKGROUND: Although adult height is inversely related with the risk of chronic disease, the association between maternal height and ischaemic placental disease remains unclear. METHODS: We used the national, multicentre Japan Society of Obstetrics and Gynecology perinatal database to assess the risk of preeclampsia, placental abruption, and small for gestational age (SGA) births (birthweight < 10th percentile), which together constitute the syndrome 'ischaemic placental disease', in relation to self-reported height in 218 412 women with no underlying diseases before pregnancy, who delivered singletons in 2005-11...
March 20, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28315895/healthy-growth-and-development
#6
Ken K Ong
Observational and experimental studies indicate a remarkably consistent association between rapid growth and weight gain during infancy and higher risks for obesity in later childhood and adult life. This association appears to be equally relevant to breastfed and formula milk-fed infants, and infants small for gestational age and with normal birth weight. The type of infant milk feeding, energy intake, and milk nutrient composition are important determinants of infant growth and weight gain. There is also accumulating evidence that genetic factors related to adult obesity susceptibility act in the central nervous system to regulate intrinsic levels of infant appetite and satiety, and they impact on infant dietary behaviors to influence growth and weight gain...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28306521/reference-ranges-of-thromboelastometry-in-healthy-full-term-and-pre-term-neonates
#7
Rozeta Sokou, Leontini Foudoulaki-Paparizos, Theodore Lytras, Aikaterini Konstantinidi, Martha Theodoraki, Ioannis Lambadaridis, Antonis Gounaris, Serena Valsami, Marianna Politou, Argyri Gialeraki, Georgios K Nikolopoulos, Nicoletta Iacovidou, Stefanos Bonovas, Argirios E Tsantes
BACKGROUND: Rotational thromboelastometry (ROTEM) is an attractive method for rapid evaluation of hemostasis in neonates. Currently, no reference values exist for ROTEM assays in full-term and pre-term neonates. Our aim was to establish reference ranges for standard extrinsically activated ROTEM assay (EXTEM) in arterial blood samples of healthy full-term and pre-term neonates. METHODS: In the present study, EXTEM assay was performed in 198 full-term (≥37 weeks' gestation) and 84 pre-term infants (<37 weeks' gestation) using peripheral arterial whole blood samples...
March 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28304325/early-feeding-tolerance-in-small-for-gestational-age-infants-with-normal-versus-abnormal-antenatal-doppler-characteristics
#8
M F Ahamed, Pe'er Dar, M Vega, Mimi Kim, Q Gao, T Havranek
OBJECTIVES: To determine differences in feeding tolerance amongst preterm small for gestational age (SGA) infants with normal versus abnormal umbilical artery Doppler flow defined as absent or reversed end diastolic flow (AREDF). METHODS: This was a retrospective cohort study of infants <35 weeks gestational age (GA) and birth weight (BW) <10th percentile. Day of initiation of feeds, days to full feeds and CRIB II scores were the primary outcomes. Clinical characteristics were compared between the groups of SGA infants with normal and AREDF...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28304324/assessment-of-serum-apolipoprotien-b-and-apolipoprotein-a-1-and-their-ratio-in-healthy-full-term-small-for-gestational-age-newborns
#9
A Agrawal, J Shrivastava, R Dwivedi, M Siddiqui
BACKGROUND: Programmed changes in growth restricted fetuses can increase the risk of adulthood diseases due to elevated serum cholesterol and apolipoprotein-B (Apo-B) concentrations. Increasing evidence demonstrated the role of apoB/apoA-I ratio as a strong risk factor for cardiovascular diseases. OBJECTIVE: To determine the concentration of cord blood lipoproteins and apolipoproteins as well as their correlation with birth weight. METHODS: This cross-sectional study was conducted in a teaching institution of central India...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28302957/relationship-between-asymmetric-dimethylarginine-in-umbilical-cord-plasma-and-birth-weight-follows-a-u-shaped-curve
#10
Junji Takaya, Yuko Tanabe, Yuichi Kuroyanagi, Kazunari Kaneko
Asymmetric dimethylarginine (ADMA) is a nonselective nitric oxide (NO) synthase inhibitor associated with cardiovascular and metabolic disorders. NO regulates placental blood flow, which plays an important role in fetal growth. Many epidemiological studies have disclosed that restricted fetal growth is associated with an increased risk of insulin resistance in adult life. We studied the relationship between ADMA in cord blood and birth size. Nine small for gestational age (SGA) and 32 appropriate for gestational age (AGA) infants were studied...
March 7, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28301893/congenital-diaphragmatic-hernia-the-side-of-diaphragmatic-defect-and-associated-nondiaphragmatic-malformations
#11
Ruža Grizelj, Katarina Bojanić, Jurica Vuković, Toby N Weingarten, Darrell R Schroeder, Juraj Sprung
Background Congenital diaphragmatic hernia (CDH) has different clinical presentations depending on whether it is right sided (R-CDH) or left sided (L-CDH). Some have suggested that L-CDH and R-CDH may represent different syndromic phenotypes. This theory would be indirectly supported if different nondiaphragmatic anomalies were associated with laterality. We assessed whether CDH laterality is associated with specific types of nondiaphragmatic anomalies. Methods Cases of CDH were retrospectively identified from five centers, and associated congenital anomalies, prenatal diagnosis, demographics, birth characteristics, and side of the CDH were analyzed...
March 16, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28299992/developmental-programming
#12
Muraly Puttabyatappa, Ashleigh Irwin, Jacob D Martin, Makeda Mesquitta, Almudena Veiga-Lopez, Vasantha Padmanabhan
Prenatal testosterone (T)-treated sheep, similar to women with polycystic ovary syndrome (PCOS), manifests reproductive defects that include multifollicular ovarian phenotype. Women with PCOS manifest increased ovarian matrix metalloproteinases (MMPs) activity. We tested the hypothesis that gestational T excess in sheep would alter ovarian expression of MMPs, tissue inhibitors of MMP (TIMP) and their target proteins laminin B (LAMB), collagen, tumor necrosis factor alpha (TNF), and connexin 43 (GJA1) consistent with increased MMP activity and that these changes are developmentally regulated...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28298861/retinopathy-of-prematurity-revisiting-incidence-and-risk-factors-from-oman-compared-to-other-countries
#13
Zenaida Soriano Reyes, Sharef Waadallah Al-Mulaabed, Flordeliz Bataclan, Cheryl Montemayor, Anuradha Ganesh, Sanaa Al-Zuhaibi, Huda Al-Waili, Fatma Al-Wahibi
PURPOSE: The purpose of this study is to determine the incidence of retinopathy of prematurity (ROP) and the maternal/neonatal risk factors at a tertiary care hospital in Oman, compared to other countries. PATIENTS AND METHODS: A retrospective analysis of premature neonates born with gestational age (GA) 24-32 weeks at Sultan Qaboos University Hospital, Oman, from January 2007 to December 2010. Maternal and neonatal in-hospital course was retrieved. The incidence of ROP was reported...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28295742/prognosis-of-isolated-congenital-diaphragmatic-hernia-using-lung-to-head-circumference-ratio-variability-across-centers-in-a-national-perinatal-network
#14
Marie-Victoire Senat, Hanane Bouchghoul, Julien Stirnemann, Pascal Vaast, Julia Boubnova, Laetitia Begue, Elizabeth Carricaburu, Agnes Sartor, Jacques Jani, Alexandra Benachi, Jean Bouyer
BACKGROUND: Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly. The observed to expected lung area-to-head circumference ratio (o/e-LHR) has been shown to provide a useful prediction of subsequent survival in fetuses with CDH in reference centers with expertise and a large caseload. However, the accuracy of o/e-LHR measurements in unselected fetal medicine units or in centers with less expertise is not well known. OBJECTIVE: To evaluate o/e-LHR measurement in prognostic evaluation of postnatal survival when the measurement is performed in fetal medicine units with different levels of expertise...
March 13, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28295227/mild-perinatal-adversities-moderate-the-association-between-maternal-harsh-parenting-and-hair-cortisol-evidence-for-differential-susceptibility
#15
Dafna A Windhorst, Ralph C A Rippe, Viara R Mileva-Seitz, Frank C Verhulst, Vincent W V Jaddoe, Gerard Noppe, Elisabeth F C van Rossum, Erica L T van den Akker, Henning Tiemeier, Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg
It has been shown that following exposure to mild perinatal adversity, children have greater susceptibility to both the negative and positive aspects of their subsequent environment. In a large population-based cohort study (N = 1,776), we investigated whether mild perinatal adversity moderated the association between maternal harsh parenting and children's hair cortisol levels, a biomarker of chronic stress. Mild perinatal adversity was defined as late preterm birth (gestational age at birth of 34-37 weeks, 6 days) or small for gestational age (birth weight between the 2...
March 13, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28295159/first-and-second-trimester-serum-tests-with-and-without-first-trimester-ultrasound-tests-for-down-s-syndrome-screening
#16
REVIEW
S Kate Alldred, Yemisi Takwoingi, Boliang Guo, Mary Pennant, Jonathan J Deeks, James P Neilson, Zarko Alfirevic
BACKGROUND: Down's syndrome occurs when a person has three copies of chromosome 21 (or the specific area of chromosome 21 implicated in causing Down's syndrome) rather than two. It is the commonest congenital cause of mental disability. Non-invasive screening based on biochemical analysis of maternal serum or urine, or fetal ultrasound measurements, allows estimates of the risk of a pregnancy being affected and provides information to guide decisions about definitive testing.  Before agreeing to screening tests, parents need to be fully informed about the risks, benefits and possible consequences of such a test...
March 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28294442/prediction-of-adverse-perinatal-outcome-by-cerebroplacental-ratio-adjusted-for-estimated-fetal-weight
#17
Angelo Sirico, Anke Diemert, Peter Glosemeyer, Kurt Hecher
OBJECTIVES: The aim of our study was to evaluate the relationship between the cerebroplacental ratio (CPR) and estimated fetal weight (EFW). Furthermore, we evaluated the role of CPR in the prediction of adverse perinatal outcome and whether CPR measurements adjusted for EFW improve its predictive value. METHODS: This is a retrospective cohort study including pregnancies, where Doppler investigations of umbilical artery (UA) and middle cerebral artery (MCA) were performed after 30 weeks...
March 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28294428/probiotics-and-antimicrobial-protein-and-peptide-levels-in-preterm-infants
#18
Tobias Strunk, Julie Hibbert, Dorota Doherty, Caitlyn Granland, Stephanie Trend, Karen Simmer, David Burgner, Sanjay Patole, Andrew Currie
AIM: To characterise the secreted and inducible antimicrobial protein and peptide (APP) levels in a prospective cohort of preterm infants (<30 weeks gestational age) with or without Bifidobacterium breve M16V supplementation during the first month of life. METHODS: We analysed serial biosamples of infants who did (n=13) or did not receive (n=62) B. breve (3×10(9) cfu/day). Peripheral blood was obtained on days 1, 14 and 28, and infant stool prior to commencement of probiotic supplementation and on day 21...
March 12, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28292964/longitudinal-evaluation-of-growth-in-oesophageal-atresia-patients-up-to-12%C3%A2-years
#19
Floor W T Vergouwe, Marjolein Spoel, Nicole W G van Beelen, Saskia J Gischler, René M H Wijnen, Joost van Rosmalen, Hanneke IJsselstijn
OBJECTIVE: Previous studies reported diminished growth after oesophageal atresia (OA) repair. We evaluated long-term follow-up data on growth. METHODS: Longitudinal cohort study up to 12 years. Patients with OA, born 1999-2013, who participated in a longitudinal follow-up programme were included. Children with genetic syndromes associated with growth disorders were excluded. SD scores (SDS) for height-for-age (HFA), weight-for-height (WFH) and distance-to-target-height were calculated for routine visits (0...
March 14, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28292615/perinatal-outcomes-among-singletons-after-assisted-reproductive-technology-with-single-embryo-or-double-embryo-transfer-versus-no-assisted-reproductive-technology
#20
Angela S Martin, Jeani Chang, Yujia Zhang, Jennifer F Kawwass, Sheree L Boulet, Patricia McKane, Dana Bernson, Dmitry M Kissin, Denise J Jamieson
OBJECTIVE: To examine outcomes of singleton pregnancies conceived without assisted reproductive technology (non-ART) compared with singletons conceived with ART by elective single-embryo transfer (eSET), nonelective single-embryo transfer (non-eSET), and double-embryo transfer with the establishment of 1 (DET -1) or ≥2 (DET ≥2) early fetal heartbeats. DESIGN: Retrospective cohort using linked ART surveillance data and vital records from Florida, Massachusetts, Michigan, and Connecticut...
March 11, 2017: Fertility and Sterility
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