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https://www.readbyqxmd.com/read/29139556/delivery-outcomes-of-large-for-gestational-age-newborns-stratified-by-the-presence-or-absence-of-gestational-diabetes-mellitus
#1
Hadar Rosen, Anat Shmueli, Eran Ashwal, Liran Hiersch, Yariv Yogev, Amir Aviram
OBJECTIVE: To evaluate separate and combined contributions of gestational diabetes mellitus (GDM) and large-for-gestational age (LGA) on delivery outcomes. METHODS: In a retrospective cohort study of term singleton deliveries between 2007 and 2014 in Tel Aviv, Israel, outcomes were compared between non-GDM/AGA pregnancies (reference) and three study groups: non-GDM/LGA, GDM/appropriate for gestational age (AGA) and GDM/LGA. RESULTS: Overall, there were 62 102 deliveries, of which 53 201 (85...
November 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29138203/does-the-impact-of-a-plant-based-diet-during-pregnancy-on-birth-weight-differ-by-ethnicity-a-dietary-pattern-analysis-from-a-prospective-canadian-birth-cohort-alliance
#2
Michael A Zulyniak, Russell J de Souza, Mateen Shaikh, Dipika Desai, Diana L Lefebvre, Milan Gupta, Julie Wilson, Gita Wahi, Padmaja Subbarao, Allan B Becker, Piush Mandhane, Stuart E Turvey, Joseph Beyene, Stephanie Atkinson, Katherine M Morrison, Sarah McDonald, Koon K Teo, Malcolm R Sears, Sonia S Anand
OBJECTIVE: Birth weight is an indicator of newborn health and a strong predictor of health outcomes in later life. Significant variation in diet during pregnancy between ethnic groups in high-income countries provides an ideal opportunity to investigate the influence of maternal diet on birth weight. SETTING: Four multiethnic birth cohorts based in Canada (the NutriGen Alliance). PARTICIPANTS: 3997 full-term mother-infant pairs of diverse ethnic groups who had principal component analysis-derived diet pattern scores-plant-based, Western and health-conscious-and birth weight data...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29132221/2009-iom-guidelines-for-gestational-weight-gain-how-well-do-they-predict-outcomes-across-ethnic-groups
#3
Amal R Khanolkar, Gillian E Hanley, Ilona Koupil, Patricia A Janssen
OBJECTIVE: To determine whether the Institute Of Medicine's (IOM) 2009 guidelines for weight-gain during pregnancy are predictive of maternal and infant outcomes in ethnic minority populations. METHODS: We designed a population-based study using administrative data on 181,948 women who delivered live singleton births in Washington State between 2006-2008. We examined risks of gestational hypertension, preeclampsia/eclampsia, cesarean delivery, and extended hospital stay in White, Black, Native-American, East-Asian, Hispanic, South-Asian and Hawaiian/Pacific islander women according to whether they gained more or less weight during pregnancy than recommended by IOM guidelines...
November 13, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29121870/trends-in-newborn-umbilical-cord-care-practices-in-sokoto-and-bauchi-states-of-nigeria-the-where-who-how-what-and-the-ubiquitous-role-of-traditional-birth-attendants-a-lot-quality-assurance-sampling-survey
#4
Dele Abegunde, Nosa Orobaton, Katherine Beal, Amos Bassi, Moyosola Bamidele, Toyin Akomolafe, Francis Ohanyido, Olayinka Umar-Farouk, Saba'atu Danladi
BACKGROUND: Neonatal infections caused by unsafe umbilical cord practices account for the majority of neonatal deaths in Nigeria. We examined the trends in umbilical cord care practices between 2012 and 2015 that coincided with the introduction of chlorhexidine digluconate 7.1% gel in Bauchi and Sokoto States. METHODS: We obtained data from three rounds of lot quality assurance samples (LQAS) surveys conducted in 2012, 2013 and 2015. Households were randomly sampled in each round that totaled 1140 and 1311 households in Bauchi and Sokoto States respectively...
November 9, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29121112/fetal-overgrowth-in-women-with-type-1-and-type-2-diabetes-mellitus
#5
Linnea Ladfors, Nael Shaat, Nana Wiberg, Anastasia Katasarou, Kerstin Berntorp, Karl Kristensen
OBJECTIVES: Despite improved glycemic control, the rate of large-for-gestational-age (LGA) infants remains high in pregnancies complicated by diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Poor glycemic control, obesity, and excessive gestational weight gain are the main risk factors. The aim of this study was to determine the relative contribution of these risk factors for LGA in women with T1DM and T2DM, after controlling for important confounders such as age, smoking, and parity...
2017: PloS One
https://www.readbyqxmd.com/read/29111312/perinatal-outcomes-after-stimulated-versus-natural-cycle-ivf-a-systematic-review-and-meta-analysis
#6
REVIEW
Mohan Shashikant Kamath, Richard Kirubakaran, Mariano Mascarenhas, Sesh Kamal Sunkara
Pregnancies resulting from assisted reproductive techniques are at higher risk of adverse perinatal outcomes compared with spontaneous conceptions. Underlying infertility and IVF procedures have been linked to adverse perinatal outcomes. It is important to know if ovarian stimulation influences perinatal outcomes after IVF. A systematic search for relevant studies was conducted up to November 2016 on the following databases: PubMed, EMBASE, DARE and Cochrane Central Register of Controlled Trials. Perinatal outcomes included preterm birth (PTB), low birth weight (LBW), small for gestational age (SGA), large for gestational age (LGA) and congenital anomalies...
October 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29110097/geographic-region-socioeconomic-position-and-the-utilisation-of-primary-total-joint-replacement-for-hip-or-knee-osteoarthritis-across-western-victoria-a-cross-sectional-multilevel-study-of-the-australian-orthopaedic-association-national-joint-replacement-registry
#7
Sharon Brennan-Olsen, Sara Vogrin, Kara L Holloway, Richard S Page, Muhammad A Sajjad, Mark A Kotowicz, Patricia M Livingston, Mustafa Khasraw, Sharon Hakkennes, Trish L Dunning, Susan Brumby, Daryl Pedler, Alasdair Sutherland, Svetha Venkatesh, Lana J Williams, Gustavo Duque, Julie A Pasco
Compared to urban residents, those in rural/regional areas often experience inequitable healthcare from specialist service providers. Independent of small between-area differences in utilisation, socially advantaged groups had the greatest uptake of joint replacement. These data suggest low correlation between 'need' vs. 'uptake' of surgery in rural/regional areas. BACKGROUND AND PURPOSE: Compared to urban residents, those in rural and regional areas often experience inequitable healthcare from specialist service providers, often due to geographical issues...
November 6, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29104027/risk-of-abnormal-fetal-growth-in-women-with-early-and-late-onset-preeclampsia
#8
Tai-Ho Hung, T'sang-T'ang Hsieh, Szu-Fu Chen
OBJECTIVES: To investigate the risks of delivering small-for-gestational-age (SGA) and large-for-gestational-age (LGA) infants in women with early- (delivered before 34weeks of gestation) and late-onset (delivered at or after 34weeks of gestation) preeclampsia. STUDY DESIGN: We conducted a retrospective cohort study of 29,494 singleton deliveries after 24weeks' gestation, excluding pregnancies complicated by fetal anomalies, stillbirths, and prepregnancy diabetes mellitus...
September 11, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29094455/incidence-of-gastric-adenocarcinoma-among-lesions-diagnosed-as-low-grade-adenoma-dysplasia-on-endoscopic-biopsy-a-multi-center-prospective-observational-study
#9
Akira Maekawa, Motohiko Kato, Takeshi Nakamura, Masato Komori, Takuya Yamada, Katsumi Yamamoto, Hideharu Ogiyama, Masanori Nakahara, Naoki Kawai, Takamasa Yabuta, Akira Mukai, Yoshito Hayashi, Tsutomu Nishida, Hideki Iijima, Masahiko Tsujii, Eiichi Morii, Tetsuo Takehara
OBJECTIVES: Differentiation between gastric adenocarcinoma and low-grade adenoma/dysplasia (LGA) on endoscopic forceps biopsy is difficult. We aimed to clarify the incidence of carcinoma in specimens-obtained via endoscopic resection (ER)-from cases that had been diagnosed as LGA (Vienna category 3) on endoscopic biopsy. METHODS: In this multi-center, prospective, observational study, patients with gastric adenoma (Vienna category 3 or 4.1) diagnosed on endoscopic forceps biopsy were enrolled...
November 2, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29091765/low-grade-astrocytoma-mutations-in-idh1-p53-and-atrx-cooperate-to-block-differentiation-of-human-neural-stem-cells-via-repression-of-sox2
#10
Aram S Modrek, Danielle Golub, Themasap Khan, Devin Bready, Jod Prado, Christopher Bowman, Jingjing Deng, Guoan Zhang, Pedro P Rocha, Ramya Raviram, Charalampos Lazaris, James M Stafford, Gary LeRoy, Michael Kader, Joravar Dhaliwal, N Sumru Bayin, Joshua D Frenster, Jonathan Serrano, Luis Chiriboga, Rabaa Baitalmal, Gouri Nanjangud, Andrew S Chi, John G Golfinos, Jing Wang, Matthias A Karajannis, Richard A Bonneau, Danny Reinberg, Aristotelis Tsirigos, David Zagzag, Matija Snuderl, Jane A Skok, Thomas A Neubert, Dimitris G Placantonakis
Low-grade astrocytomas (LGAs) carry neomorphic mutations in isocitrate dehydrogenase (IDH) concurrently with P53 and ATRX loss. To model LGA formation, we introduced R132H IDH1, P53 shRNA, and ATRX shRNA into human neural stem cells (NSCs). These oncogenic hits blocked NSC differentiation, increased invasiveness in vivo, and led to a DNA methylation and transcriptional profile resembling IDH1 mutant human LGAs. The differentiation block was caused by transcriptional silencing of the transcription factor SOX2 secondary to disassociation of its promoter from a putative enhancer...
October 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/29089177/trajectories-of-maternal-leisure-time-physical-activity-and-sedentary-behavior-during-adolescence-to-young-adulthood-and-offspring-birthweight
#11
Sylvia E Badon, Alyson J Littman, Kwun Chuen Gary Chan, Michelle A Williams, Daniel A Enquobahrie
PURPOSE: The objectives of the study were to determine the extent to which trajectories of maternal preconception leisure-time physical activity (LTPA) and leisure-time sedentary behavior (LTSB) during adolescence and young adulthood are associated with offspring birth weight (BW) and to test if these associations differ by offspring sex or maternal pre-pregnancy overweight-obese status. METHODS: Participants with one or more birth (n = 1408) were identified from the National Longitudinal Study of Adolescent to Adult Health...
October 13, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29078890/novel-mouse-models-of-hepatic-artery-infusion
#12
Minhyung Kim, Daniel T Fisher, Colin A Powers, Emmanuel M Gabriel, Alexis M Korman, Sandra Sexton, Andrei V Gudkov, Joseph J Skitzki
BACKGROUND: The liver has unique anatomy in that most blood flow to normal hepatocytes is derived from the portal venous system, whereas liver tumors obtain their nutrient blood supply exclusively from the hepatic artery. The focused arterial delivery of anticancer agents to liver tumors has been performed for decades; however, preclinical models to standardize drug regimens and examine novel agents have been lacking. The purpose of this study was to establish preclinical hepatic artery infusion (HAI) models in a mouse and to evaluate the safety and delivery capability of the models...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29076569/assessing-the-impact-of-vulnerability-on-perceptions-of-social-cohesion-in-the-context-of-community-resilience-to-disaster-in-the-blue-mountains
#13
Sarah Redshaw, Valerie Ingham, Marion McCutcheon, John Hicks, Oliver Burmeister
OBJECTIVE: To assess the impact of network communications, community participation and elements of vulnerability on the perception of social cohesiveness in the Blue Mountains local government area (Blue Mountains LGA). DESIGN: A questionnaire was administered to residents of the Blue Mountains LGA. Econometric analysis of the resulting data was undertaken. SETTING: Blue Mountains LGA, Australia. PARTICIPANTS: One thousand one hundred and three residents of the Blue Mountains LGA responded to the questionnaire...
October 27, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29074472/external-validation-study-of-first-trimester-obstetric-prediction-models-expect-study-i-research-protocol-and-population-characteristics
#14
Linda Jacqueline Elisabeth Meertens, Hubertina Cj Scheepers, Raymond G De Vries, Carmen D Dirksen, Irene Korstjens, Antonius Lm Mulder, Marianne J Nieuwenhuijze, Jan G Nijhuis, Marc Ea Spaanderman, Luc Jm Smits
BACKGROUND: A number of first-trimester prediction models addressing important obstetric outcomes have been published. However, most models have not been externally validated. External validation is essential before implementing a prediction model in clinical practice. OBJECTIVE: The objective of this paper is to describe the design of a study to externally validate existing first trimester obstetric prediction models, based upon maternal characteristics and standard measurements (eg, blood pressure), for the risk of pre-eclampsia (PE), gestational diabetes mellitus (GDM), spontaneous preterm birth (PTB), small-for-gestational-age (SGA) infants, and large-for-gestational-age (LGA) infants among Dutch pregnant women (Expect Study I)...
October 26, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29072230/a-survey-of-the-perception-of-the-quality-of-and-preference-of-healthcare-services-amongst-residents-of-abeokuta-south-local-government-ogun-state-nigeria
#15
A S Oredola, O O Odusanya
BACKGROUND: The choice of healthcare facilities by individuals is determined in part by their taste, satisfaction with services, and the perceived quality of care provided. The aim of the study was to explore the healthcare preferences of residents of Abeokuta South Local Government Area (LGA) and their perception of quality of services received, and to determine the factors influencing their choice of healthcare facilities. MATERIALS AND METHODS: A descriptive cross-sectional study design was used to assess perception of clients regarding quality of healthcare received and their choice of healthcare service delivery...
September 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29071262/left-gastric-artery-reconstruction-after-distal-pancreatectomy-with-celiac-axis-en-bloc-resection-how-we-do-it
#16
Ken-Ichi Okada, Seiko Hirono, Manabu Kawai, Shinya Hayami, Shinichi Asamura, Yoshitaka Wada, Masaki Ueno, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Hiroki Yamaue
BACKGROUND/AIMS: Ischemic gastropathy remains as a persistent problem after left gastric artery (LGA) resection in distal pancreatectomy with celiac axis en-bloc resection (DP-CAR). The middle colic artery (MCA) was found to be a useful vessel for compromised collateral flow. However, intraoperative gross evaluation of gastric ischemia is technically difficult even after artery reconstruction. METHODS: We performed LGA reconstruction by MCA-LGA bypass after LGA-resecting DP-CAR assisted by intraoperative indocyanine green fluorescence imaging (ICG) blood flow evaluation in a clinical trial (UMIN000020414)...
September 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/29063494/bariatric-embolization-of-the-left-gastric-arteries-for-the-treatment-of-obesity-9-month-data-in-5-patients
#17
Zhi-Bin Bai, Yong-Lin Qin, Gang Deng, Guo-Feng Zhao, Bin-Yan Zhong, Gao-Jun Teng
PURPOSE: The purpose of this study is to investigate the safety and 9-month effectiveness of transcatheter left gastric artery embolization (LGAE) for treating patients with obesity. MATERIALS AND METHODS: The protocol of this study was approved by the Institutional Ethics Review Board. Five obese patients (3 men and 2 women) with mean weight of 102.0 ± 16.19 kg (range, 82.1-125.5 kg) and mean body mass index (BMI) of 38.1 kg/m(2) ± 3.8 (range, 32.9-42...
October 23, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29058576/lcs-ta-to-identify-similar-fragments-in-rna-3d-structures
#18
Jakub Wiedemann, Tomasz Zok, Maciej Milostan, Marta Szachniuk
BACKGROUND: In modern structural bioinformatics, comparison of molecular structures aimed to identify and assess similarities and differences between them is one of the most commonly performed procedures. It gives the basis for evaluation of in silico predicted models. It constitutes the preliminary step in searching for structural motifs. In particular, it supports tracing the molecular evolution. Faced with an ever-increasing amount of available structural data, researchers need a range of methods enabling comparative analysis of the structures from either global or local perspective...
October 23, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29049303/a-mediterranean-diet-with-additional-extra-virgin-olive-oil-and-pistachios-reduces-the-incidence-of-gestational-diabetes-mellitus-gdm-a-randomized-controlled-trial-the-st-carlos-gdm-prevention-study
#19
RANDOMIZED CONTROLLED TRIAL
Carla Assaf-Balut, Nuria García de la Torre, Alejandra Durán, Manuel Fuentes, Elena Bordiú, Laura Del Valle, Cristina Familiar, Ana Ortolá, Inés Jiménez, Miguel A Herraiz, Nuria Izquierdo, Noelia Perez, María J Torrejon, María I Ortega, Francisco J Illana, Isabelle Runkle, Maria P de Miguel, Carmen Montañez, Ana Barabash, Martín Cuesta, Miguel A Rubio, Alfonso L Calle-Pascual
BACKGROUND: Gestational diabetes mellitus (GDM) prevalence is increasing and becoming a major public health concern. Whether a Mediterranean diet can help prevent GDM in unselected pregnant women has yet to be studied. METHODS: We conducted a prospective, randomized controlled trial to evaluate the incidence of GDM with two different dietary models. All consecutive normoglycemic (<92 mg/dL) pregnant women at 8-12 gestational weeks (GW) were assigned to Intervention Group (IG, n = 500): MedDiet supplemented with extra virgin olive oil (EVOO) and pistachios; or Control Group (CG, n = 500): standard diet with limited fat intake...
2017: PloS One
https://www.readbyqxmd.com/read/29037224/maternal-and-fetal-blood-lipid-concentrations-during-pregnancy-differ-by-maternal-body-mass-index-findings-from-the-rolo-study
#20
Aisling A Geraghty, Goiuri Alberdi, Elizabeth J O'Sullivan, Eileen C O'Brien, Brenda Crosbie, Patrick J Twomey, Fionnuala M McAuliffe
BACKGROUND: Pregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations have been associated with adverse pregnancy outcomes such as gestational diabetes, pregnancy-induced hypertension and high birth weight. As blood lipids are not routinely measured during pregnancy, there is limited information on what is considered normal during pregnancy and in fetal blood...
October 16, 2017: BMC Pregnancy and Childbirth
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