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https://www.readbyqxmd.com/read/27911105/associations-between-maternal-bmi-as-well-as-glucose-tolerance-and-adverse-pregnancy-outcomes-in-women-with-polycystic-ovary-syndrome
#1
Ying-Ying Li, Su-Qi Ye, Zhuo-Hui Zhong, Qiong Xu, Wei-Bi Mai, Cai-Xin Yin, Zhi-Qin Zhu, Xiao-Qian He, Qing Xiao
This retrospective, cohort study examined the association between maternal pre-pregnancy body mass index (BMI), independent of glucose tolerance and adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), for which there are few previous studies. Medical records from 2012 to 2015 at Guangzhou Women and Children's Medical Center, China were reviewed for women previously diagnosed with PCOS with normal 2-h 75-g oral glucose tolerance test (OGTT) results (n = 1249). The separate and joint effects of maternal BMI and glucose levels on pregnancy outcomes were assessed...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27909843/increased-risk-of-large-for-gestational-age-birthweight-in-singleton-siblings-conceived-with-in-vitro-fertilization-in-frozen-versus-fresh-cycles
#2
Barbara Luke, Morton B Brown, Ethan Wantman, Judy E Stern, James P Toner, Charles C Coddington
BACKGROUND: Children born from fresh in vitro fertilization (IVF) cycles are at greater risk of being born smaller and earlier, even when limited to singletons; those born from frozen cycles have an increased risk of large-for-gestational age (LGA) birthweight (z-score ≥1.28). This analysis sought to overcome limitations in other studies by using pairs of siblings, and accounting for prior cycle outcomes, maternal characteristics, and embryo state and stage. METHODS: Pairs of singleton births conceived with IVF and born between 2004 and 2013 were identified from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database, matched for embryo stage (blastocyst versus non-blastocyst) and infant gender, categorized by embryo state (fresh versus frozen) in 1st and 2nd births (four groups)...
December 1, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27901638/atlantic-dip-insulin-therapy-for-women-with-iadpsg-diagnosed-gestational-diabetes-mellitus-does-it-work
#3
D Bogdanet, A M Egan, C Reddin, O Kgosidialwa, B Kirwan, L Carmody, F P Dunne
INTRODUCTION: Approximately 40% of women with gestational diabetes mellitus (GDM) diagnosed using IADPSG criteria require insulin therapy. OBJECTIVE: To assess if the outcomes for women with GDM treated with insulin are comparable to women with normal glucose tolerance (NGT). MATERIALS AND METHODS: This retrospective cohort study included 752 women with insulin-treated GDM and 2496 women with NGT during pregnancy. Maternal and foetal outcomes were examined...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27888796/altered-dna-methylation-in-neonates-born-large-for-gestational-age-is-associated-with-cardiometabolic-risk-in-children
#4
Xian-Hua Lin, Dan-Dan Wu, Ling Gao, Jun-Yu Zhang, Hai-Tao Pan, Hui Wang, Cheng Li, Ping Zhang, Meng-Xi Guo, Yan-Ting Wu, Ya-Jing Tan, Li Jin, Yu-Qian Xiang, Ju-Xue Li, Jian-Zhong Sheng, He-Feng Huang
BACKGROUND: Infants being born Large-for-gestational-age (LGA) are prone to developing cardiometabolic disease. However, the underlying mechanisms remain unclear. RESULTS: Clinical investigation showed that children born LGA had significantly higher serum level of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and insulin, ratio of TC/high-density lipoprotein-cholesterol (HDL-c) compared to children born appropriate for gestational age (AGA)...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27883318/maternal-lipids-may-predict-fetal-growth-in-type-2-diabetes-mellitus-and-gestational-diabetes-mellitus-pregnancies
#5
Brankica Krstevska, Sasha Misevska Jovanovska, Slagjana Simeonova Krstevska, Valentina Velkoska Nakova, Vladimir Serafimoski
AIM: During diabetic pregnancy, complex metabolic changes occur in the lipid profile. The aim of the study was to determine the predictive values of maternal serum lipid levels on large-for-gestational age newborns during the third trimester in pregnancies of women with type 2 diabetes mellitus (DM2) and gestational diabetes mellitus (GDM). MATERIAL AND METHODS: Data of forty three pregnancies of women with DM2 and two hundred women with GDM were analyzed. The analysis encompassed the following parameters: age, body mass index (BMI), lipid parameters, HbA1c in first, second and third trimester of pregnancy, preeclampsia and baby birth weight...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27853747/can-magnifying-endoscopy-with-narrow-band-imaging-discriminate-between-carcinomas-and-low-grade-adenomas-in-gastric-superficial-elevated-lesions
#6
Takashi Nonaka, Masahiko Inamori, Yasushi Honda, Kenji Kanoshima, Yumi Inoh, Mizue Matsuura, Shiori Uchiyama, Eiji Sakai, Takuma Higurashi, Hidenori Ohkubo, Hiroshi Iida, Hiroki Endo, Koji Fujita, Akihiko Kusakabe, Kazuhiro Atsukawa, Hisao Takahashi, Yoko Tateishi, Shin Maeda, Kenichi Ohashi, Atsushi Nakajima
: Background and study aims: The aim of this study was to investigate the capability of magnifying endoscopy with narrow-band imaging (ME-NBI) to discriminate between early carcinomas (EC) and low grade adenomas (LGA) in gastric superficial elevated epithelial neoplasias. Patients and methods: We investigated 100 consecutive cases of gastric superficial elevated epithelial neoplasias that were removed using endoscopic submucosal dissection. The pathological diagnostic criteria were based on the revised Vienna classification; category 4 (mucosal high grade neoplasia) and category 5 (submucosal invasion by carcinoma) lesions were diagnosed as EC, whereas category 3 (mucosal low grade neoplasia) lesions were diagnosed as LGA...
November 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27846369/prevalence-of-trachoma-in-bauchi-state-nigeria-results-of-20-local-government-area-level-surveys
#7
Caleb Mpyet, Nasiru Muhammad, Mohammed Dantani Adamu, Habila Muazu, Murtala Muhammad Umar, Mohammed Abdull, Joel Alada, Musa Goyol, Uwaezuoke Onyebuchi, Francisca Olamiju, Sunday Isiyaku, Adamani William, Benjamin C Nwobi, Rebecca Willis, Rebecca Mann Flueckiger, Alex Pavluck, Brian K Chu, Nicholas Olobio, Anthony W Solomon
PURPOSE: To determine the prevalence of trachomatous inflammation - follicular (TF) and trichiasis in each of the 20 local government areas (LGAs) of Bauchi State, Nigeria. METHODS: We undertook a population-based prevalence survey in each LGA in Bauchi State, employing the Global Trachoma Mapping Project methodology. We used a 2-stage, systematic and quasi-random sampling strategy. Using probability proportional to size, we selected 25 clusters, in each of which 25 households were selected by random walk...
November 15, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27828938/growth-and-body-mass-index-during-the-first-14-years-of-life-in-offspring-from-women-with-type-1-or-type-2-diabetes-mellitus
#8
Nurah M Hammoud, Harold W de Valk, Lenie van Rossem, Douwe H Biesma, Jan M Wit, Gerard H A Visser
BACKGROUNDInfants of women with pregestational diabetes are at risk for developing obesity in later life. This study aimed to identify subgroups at highest risk, by studying growth profiles of offspring from women with type 1 or 2 diabetes mellitus (ODM1, ODM2) until the age of 14 years.METHODSInformation from infant welfare centers was received for 78 ODM1 and 44 ODM2. Mean BMI standard deviation scores (SDS) (based on 1980 nation-wide references) and height SDS (based on 2009 references) were calculated and included in a random-effects model...
November 9, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27823881/aliphatic-and-alicyclic-camphor-imines-as-effective-inhibitors-of-influenza-virus-h1n1
#9
Anastasiya S Sokolova, Оlga I Yarovaya, Dmitry S Baev, Аndrey V Shernyukov, Anna A Shtro, Vladimir V Zarubaev, Nariman F Salakhutdinov
A series of camphor derived imines was synthesised and evaluated in vitro for antiviral activity. Theoretical evaluations of ADME properties were also carried out. Most of these compounds exhibited significant activity against the drug-resistant strains of influenza A virus. Especially, compounds 2 (SI = 632) and 3 (SI = 417) presented high inhibition against influenza subtypes A/Puerto Rico/8/34 and A/California/07/09 of H1N1pdm09. Analysis of the structure-activity relationship showed that the activity was strongly dependent on the length of the aliphatic chain: derivatives with a shorter chain possessed higher activity, while the suppressing action of compounds with long aliphatic chains was lower...
October 19, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27819165/lipoxin-a4-lxa4-as-a-potential-first-trimester-biochemical-marker-of-intrauterine-growth-disorders
#10
Michał Lipa, Dorota Bomba-Opoń, Jacek Lipa, Paweł Bartnik, Zbigniew Bartoszewicz, Mirosław Wielgoś
OBJECTIVE: To evaluate first trimester maternal serum levels of lipoxin A4 (LXA4) in prediction of intrauterine fetal growth. METHODS: Study group of 185 patients in singleton pregnancy divided into 3 subgroups according to neonatal birthweight: ≤10 th percentile (SGA), 11- 89th percentile (AGA) and ≥90 percentile (LGA). RESULTS: We observed decreased values of LXA4 concentations, both in SGA- and LGA groups, when compared to AGA (68.91±33...
November 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27814763/scaling-up-the-use-of-sulfadoxine-pyrimethamine-for-the-preventive-treatment-of-malaria-in-pregnancy-results-and-lessons-on-scalability-costs-and-programme-impact-from-three-local-government-areas-in-sokoto-state-nigeria
#11
Nosa Orobaton, Anne M Austin, Dele Abegunde, Mohammed Ibrahim, Zainab Mohammed, Jumare Abdul-Azeez, Hakeem Ganiyu, Zwalle Nanbol, Bolaji Fapohunda, Katherine Beal
BACKGROUND: Intermittent preventive treatment of malaria in pregnancy with 3+ doses of sulfadoxine-pyrimethamine (IPTp-SP) reduces maternal mortality and stillbirths in malaria endemic areas. Between December 2014 and December 2015, a project to scale up IPTp-SP to all pregnant women was implemented in three local government areas (LGA) of Sokoto State, Nigeria. The intervention included community education and mobilization, household distribution of SP, and community health information systems that reminded mothers of upcoming SP doses...
November 4, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27802270/single-and-serial-fetal-biometry-to-detect-preterm-and-term-small-and-large-for-gestational-age-neonates-a-longitudinal-cohort-study
#12
Adi L Tarca, Edgar Hernandez-Andrade, Hyunyoung Ahn, Maynor Garcia, Zhonghui Xu, Steven J Korzeniewski, Homam Saker, Tinnakorn Chaiworapongsa, Sonia S Hassan, Lami Yeo, Roberto Romero
OBJECTIVES: To assess the value of single and serial fetal biometry for the prediction of small- (SGA) and large-for-gestational-age (LGA) neonates delivered preterm or at term. METHODS: A cohort study of 3,971 women with singleton pregnancies was conducted from the first trimester until delivery with 3,440 pregnancies (17,334 scans) meeting the following inclusion criteria: 1) delivery of a live neonate after 33 gestational weeks and 2) two or more ultrasound examinations with fetal biometry parameters obtained at ≤36 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27798635/platform-independent-genome-wide-pattern-of-dna-copy-number-alterations-predicting-astrocytoma-survival-and-response-to-treatment-revealed-by-the-gsvd-formulated-as-a-comparative-spectral-decomposition
#13
Katherine A Aiello, Orly Alter
We use the generalized singular value decomposition (GSVD), formulated as a comparative spectral decomposition, to model patient-matched grades III and II, i.e., lower-grade astrocytoma (LGA) brain tumor and normal DNA copy-number profiles. A genome-wide tumor-exclusive pattern of DNA copy-number alterations (CNAs) is revealed, encompassed in that previously uncovered in glioblastoma (GBM), i.e., grade IV astrocytoma, where GBM-specific CNAs encode for enhanced opportunities for transformation and proliferation via growth and developmental signaling pathways in GBM relative to LGA...
2016: PloS One
https://www.readbyqxmd.com/read/27797673/baseline-hba1c-to-identify-high-risk-gestational-diabetes-utility-in-early-versus-standard-gestational-diabetes
#14
Arianne Natasha Sweeting, Glynis P Ross, Jon Hyett, Lynda Molyneaux, Kris Tan, Maria Constantino, Anna Jane Harding, Jencia Wong
CONTEXT: The increasing prevalence of gestational diabetes (GDM) necessitates risk stratification measures directing limited antenatal resources to those at greatest risk. Recent evidence demonstrates that an early pregnancy HbA1c≥5.9% (41 mmol/mol) predicts adverse pregnancy outcomes. OBJECTIVE: Determine the optimal HbA1c threshold for adverse pregnancy outcomes in GDM in a treated multi-ethnic cohort and whether this differs in women diagnosed <24 versus ≥24 weeks' gestation (early versus standard GDM)...
October 31, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27795833/timing-and-cause-of-perinatal-mortality-for-small-for-gestational-age-babies-in-south-africa-critical-periods-and-challenges-with-detection
#15
Tina Lavin, David B Preen, Robert Pattinson
BACKGROUND: Little information exists on timing and cause of death for small-for-gestational-age (SGA) babies in low-and-middle-income-countries (LMICs), despite evidence from high-income countries suggesting critical periods for SGA babies. This study explored the timing and cause of stillbirth and early neonatal mortality (END, <7 days) by small-for-gestational age in three provinces in South Africa. In South Africa, the largest category of perinatal deaths is unexplained stillbirth, of which up to one-quarter have intra-uterine growth restriction...
2016: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/27791436/the-association-between-serum-ghrelin-levels-and-large-for-gestational-age-fetuses-in-patients-with-gestational-diabetes-mellitus
#16
Hülya Ayık Aydın, Aysel Derbent Uysal, Onur Erol, Hamit Yaşar Ellidağ, Aslı Bayındır, Necat Yılmaz
We aimed to determine the relationship between serum ghrelin levels and large-for-gestational-age (LGA) fetuses in patients with gestational diabetes mellitus (GDM). A case-control study was conducted in 32 women with GDM and LGA fetuses (GDM + LGA group), 35 women with GDM and appropriate-for-gestational-age (AGA) fetuses (GDM + AGA group), 32 women with normal glucose tolerance (NGT) and LGA fetuses (NGT + LGA group), and 31 women with NGT and AGA fetuses (NGT + AGA group). All participants were recruited at the time of GDM diagnosis between 24 and 30 weeks of pregnancy...
October 28, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27787507/the-associations-between-early-pregnancy-lipid-profiles-and-pregnancy-outcomes
#17
C Wang, W Zhu, Y Wei, R Su, H Feng, E Hadar, M Hod, H Yang
OBJECTIVE: To evaluate the association between early pregnancy lipid profiles and pregnancy outcomes. STUDY DESIGN: Retrospective 6 months analysis of 5218 singleton pregnant women. Each participant's demographic and medical data were collected by questionnaires and medical records. Total cholesterol (TC), triglycerides (TG), high-density lipid cholesterol (HDL-C) and low-density lipid cholesterol (LDL-C) levels were divided into quartiles, and the women were categorized as having low (<25th percentile), referent (25 to <75th percentile) or high (>75th percentile) TC, TG, HDL-C and LDL-C values...
October 27, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27775463/prevalence-of-trachoma-in-katsina-state-nigeria-results-of-34-district-level-surveys
#18
Caleb Mpyet, Nasiru Muhammad, Mohammed Dantani Adamu, Habila Muazu, Murtala Mohammad Umar, Musa Goyol, Uwazoeke Onyebuchi, Ima Chima, Haliru Idris, Adamani William, Sunday Isiyaku, Benjamin Nwobi, Rebecca Mann Flueckiger, Rebecca Willis, Alexandre Pavluck, Brian K Chu, Nicholas Olobio, Anthony W Solomon
PURPOSE: To determine the local government area (LGA)-level prevalence of trachoma in all 34 LGAs of Katsina State. METHODS: A population-based prevalence survey was conducted in each LGA of Katsina State, using the Global Trachoma Mapping Project methodology. We used a 3-stage cluster random sampling strategy to select 25 households from each of 25 clusters. We examined all residents of selected households aged 1 year and older for the clinical signs of trachomatous inflammation-follicular (TF), trachomatous inflammation-intense and trichiasis, using the World Health Organization (WHO) simplified grading scheme...
October 24, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27743496/being-born-large-for-gestational-age-is-associated-with-earlier-pubertal-take-off-and-longer-growth-duration-a-longitudinal-study
#19
Ilaria Di Giovanni, M Loredana Marcovecchio, Valentina Chiavaroli, Tommaso de Giorgis, Francesco Chiarelli, Angelika Mohn
AIM: Perinatal factors seem to influence the onset of puberty, but there is limited information on the potential effect of large size at birth on pubertal growth. This study evaluated pubertal growth in children born large for gestational age (LGA) compared to children born appropriate for gestational age (AGA). METHODS: Longitudinal growth data collected from 70 children - 40 AGA and 30 LGA - were analysed. The ages at take-off, peak height velocity, final height and pubertal growth spurts were calculated using the Preece-Baines model I...
October 15, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27735930/prenatal-visit-utilization-and-outcomes-in-pregnant-women-with-type-ii-and-gestational-diabetes
#20
E B Carter, M G Tuuli, A O Odibo, G A Macones, A G Cahill
OBJECTIVE: To investigate the association between the number of prenatal visits (PNVs) and pregnancy outcomes in women with gestational diabetes (GDM) and Type 2 diabetes mellitus (DM). STUDY DESIGN: A 4-year prospective cohort study of women with GDM and DM and was conducted. Patients ⩾75th percentile for number of PNVs were compared with those ⩽25th percentile. The primary outcomes were large for gestational age (LGA) with birth weight >90% and neonatal intensive care unit (NICU) admission for >24 h...
October 13, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
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