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https://www.readbyqxmd.com/read/29145236/protection-by-nitrite-against-the-ischemic-effects-induced-by-acute-myocardial-infarction-in-mice
#1
Yafei Wang, Xin Song, Xia Yue, Hong Su, Yuanliang Gu, Linda Bowman, Min Ding, Baobo Zou, Jinshun Zhao, Xialu Lin
OBJECTIVE: This research was aimed to investigate the correct dose of nitrite that would act as a protection against the ischemic effects induced by acute myocardial infarction (AMI). METHODS: Mice were randomly divided into a sham-operation group (sham), an AMI operation group (AMI), and a nitrite pretreatment+AMI operation group (N+AMI). Seven days before the AMI operation, mice in the N+AMI group were pretreated with sodium nitrite in drinking water. RESULTS: One week after the AMI operation, serum lactate dehydrogenase (LDH) and creatine kinase (CK) activities in both AMI and N+AMI group were significantly higher than those in the sham group, but there were no significant differences between AMI and N+AMI mice...
November 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29142970/cardiovascular-disease-biomarkers-and-supar-in-predicting-decline-in-renal-function-a-prospective-cohort-study
#2
Salim S Hayek, Yi-An Ko, Mosaab Awad, Hina Ahmed, Brandon Gray, Kareem Mohammed Hosny, Hiroshi Aida, Melissa J Tracy, Changli Wei, Sanja Sever, Jochen Reiser, Arshed A Quyyumi
Introduction: Soluble urokinase-type plasminogen activator receptor (suPAR) strongly predicts outcomes and incident chronic kidney disease (CKD) in patients with cardiovascular disease (CVD). Whether the association between suPAR and CKD is a reflection of its overall association with chronic inflammation and poor CVD outcomes is unclear. We examined whether CVD biomarkers, including high-sensitivity C-reactive protein (hs-CRP), fibrin-degradation products (FDPs), heat-shock protein 70 (HSP-70), and high-sensitivity troponin I (hs-TnI) were associated with a decline in kidney function in the Emory Cardiovascular Biobank cohort, in which suPAR levels were shown to be predictive of both incident CKD and CVD outcomes...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142172/change-in-redox-state-and-heat-shock-protein-expression-in-an-indian-major-carp-cirrhinus-cirrhosus-exposed-to-zinc-and-lead
#3
Mahammed Moniruzzaman, Puja Midday, Anindita Dhara, Debjit Das, Indranath Ghosal, Debosree Mukherjee, Suman Bhusan Chakraborty
Fish are exposed to different heavy metals that may induce numerous physiological changes. In the present study, we examined the redox state in response to a severe stress resulting from two heavy metals (Zinc and Lead) contamination in carp Cirrhinus cirrhosus. Fish were exposed to 1/10th of LC50 of the respective metals [zinc chloride (2.72 mg/L) and lead acetate (2.53 mg/L)] for 30 days and allowed to recover for another 30 days without any metal exposure. Concentration of metals, different enzymatic and non-enzymatic antioxidant agents and expression levels of heat shock protein (HSP) 70 and 90 were measured in the liver and the kidney of fish...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29131485/in-vitro-effects-of-serotonin-melatonin-and-other-related-indole-compounds-on-amyloid-%C3%AE-kinetics-and-neuroprotection
#4
Ruth Hornedo Ortega, Grégory Da Costa, Ana Belén Cerezo, Ana Mª Troncoso, Tristan Richard, Mª Carmen García Parrilla
SCOPE: Amyloid-β peptide (Aβ) is the main component of senile plaques in Alzheimer's disease (AD). The inhibition of Aβ assembly, the destabilisation of Aβ aggregates and the decrease of its cytotoxicity for the prevention of neuronal death are considered neuroprotective effects. In this work, the protective effects against Aβ aggregation and cytotoxicity of eight indolic compounds: tryptophan (Tryp), tryptamine (Trpa), serotonin (Ser), tryptophol (Phol), N-acetylserotonin (Nser), 3-indoleacetic acid (3IA), tryptophan ethyl ester (Tee) and melatonin (Mel) was evaluated...
November 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29128340/the-interaction-between-a-hsp-70-gene-variant-with-dietary-calories-in-determining-serum-markers-of-inflammation-and-cardiovascular-risk
#5
Mehrane Mehramiz, Seyed Mahdi Hassanian, Maryam Mardan-Nik, Alireza Pasdar, Khadijeh Jamialahmadi, Hamid Fiuji, Mehrdad Moetamani-Ahmadi, Seyed Mohammad Reza Parizadeh, Mohsen Moohebati, Alireza Heidari-Bakavoli, Mahmoud Ebrahimi, Gordon A Ferns, Majid Ghayour-Mobarhan, Amir Avan
BACKGROUND: The high prevalence of cardiovascular disease (CVD) globally is attributable to an interaction between environmental and genetic factors. Gene × diet interaction studies aim to explore how a modifiable factor interacts with genetic predispositions. Here we have explored the interaction of a heat shock protein (HSP70) gene polymorphism (+1267A > G) with dietary intake and their possible association with serum C-reactive protein (CRP), an inflammatory marker, that is a major component of CVD risk...
October 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29117212/quantitative-label-free-proteomic-analysis-of-human-urine-to-identify-novel-candidate-protein-biomarkers-for-schistosomiasis
#6
Olugbenga Samson Onile, Bridget Calder, Nelson C Soares, Chiaka I Anumudu, Jonathan M Blackburn
BACKGROUND: Schistosomiasis is a chronic neglected tropical disease that is characterized by continued inflammatory challenges to the exposed population and it has been established as a possible risk factor in the aetiology of bladder cancer. Improved diagnosis of schistosomiasis and its associated pathology is possible through mass spectrometry to identify biomarkers among the infected population, which will influence early detection of the disease and its subtle morbidity. METHODOLOGY: A high-throughput proteomic approach was used to analyse human urine samples for 49 volunteers from Eggua, a schistosomiasis endemic community in South-West, Nigeria...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29113061/effects-of-marine-oils-digested-with-human-fluids-on-cellular-viability-and-stress-protein-expression-in-human-intestinal-caco-2-cells
#7
Cecilia Tullberg, Gerd Vegarud, Ingrid Undeland, Nathalie Scheers
In vitro digestion of marine oils has been reported to promote lipid oxidation, including the formation of reactive aldehydes (e.g., malondialdehyde (MDA) and 4-hydroxy-2-hexenal (HHE)). We aimed to investigate if human in vitro digestion of supplemental levels of oils from algae, cod liver, and krill, in addition to pure MDA and HHE, affect intestinal Caco-2 cell survival and oxidative stress. Cell viability was not significantly affected by the digests of marine oils or by pure MDA and HHE (0-90 μM). Cellular levels of HSP-70, a chaperone involved in the prevention of stress-induced protein unfolding was significantly decreased (14%, 28%, and 14% of control for algae, cod and krill oil, respectively; p ≤ 0...
November 4, 2017: Nutrients
https://www.readbyqxmd.com/read/29107232/characterization-of-heat-shock-protein-70-transcript-from-nilaparvata-lugens-st%C3%A3-l-its-response-to-temperature-and-insecticide-stresses
#8
Kai Lu, Xia Chen, Wenting Liu, Zhichao Zhang, Ying Wang, Keke You, Yue Li, Rongbin Zhang, Qiang Zhou
The brown planthopper, Nilaparvata lugens, possesses a strong adaptability to extreme temperature and insecticide stresses. Heat shock proteins (Hsps) are highly conserved molecular chaperones and play a pivotal role in response to various environmental stresses in insects. However, little is known about the response of Hsps to stresses in N. lugens. In the present study, an inducible Hsp70 (NlHsp70) was isolated from this insect and transcriptional expression patterns of NlHsp70 under temperature and insecticide stresses were analyzed...
October 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29098576/toxicity-profile-of-organic-extracts-from-magdalena-river-sediments
#9
Lesly Tejeda-Benítez, Katia Noguera-Oviedo, Diana S Aga, Jesus Olivero-Verbel
The Magdalena River, the main river of Colombia, receives contaminated effluents from different anthropogenic activities along its path. However, the Magdalena River is used as drinking water source for approximately 30 million inhabitants, as well as a major source of fish for human consumption. Only a few studies have been conducted to evaluate the environmental and toxicological quality of the Magdalena River. To evaluate sediment toxicity, wild-type and GFP transgenic Caenorhabditis elegans were exposed to methanolic extracts, and effects on lethality, locomotion, growth, and gene expression were determined based on fluorescence spectroscopy...
November 2, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29089475/melatonin-and-or-rowatinex-attenuate-streptozotocin-induced-diabetic-renal-injury-in-rats
#10
Tarek K Motawi, Samia A Ahmed, Manal A Hamed, Shohda A El-Maraghy, Wessam M Aziz
The study aimed to explore the prophylactic effect of melatonin, rowatinex; a naturally occurring renal drug, and its combination on diabetic nephropathy in type 2 diabetic rats. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin (50 mg/g body weight). Three days before diabetes induction, rats were daily treated with melatonin, rowatinex and their combination continuously for 8 weeks. Evaluation was done through measuring blood urea nitrogen (BUN), serum uric acid, serum creatinine, urine creatinine, creatinine clearance, nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), total antioxidant capacity (TAC), kidney injury molecule-1 (KIM-1), heat shock protein-70 (HSP-70), caspase-3, transforming growth factor β1 (TGFβ1), DNA degradation by the comet assay and total protein contents...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29071995/-effects-of-electroacupuncture-and-moxibustion-pretreatment-on-expressions-of-hsp-27-hsp-70-hsp-90-at-different-time-points-in-rabbits-with-myocardial-ischemia-reperfusion-injury
#11
Cheng-Fu Tan, Jie Yan, Chao Wang, Xiao-Rong Chang, Wen-Juan Xie, Jing-Jing Yang, Mi Liu, Hai-Bo Lin, Xiang-Chang He
OBJECTIVE: To observe the effect of electroacupuncture (EA) and moxibustion (Moxi) pretreatment on expression of myocardial heat shock protein (HSP) in acute myocardial ischemia-reperfusion injury (MIRI) rabbits. METHODS: A total of 72 New Zealand rabbits were randomly divided into 4 groups:sham operation, MIRI model, EA pretreatment and Moxi pretreatment (n=18 rabbits in each group) which were further divided into 0, 24 and 48 h (time-point) subgroups (n=6 in each)...
February 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29056701/prevalence-of-selected-zoonotic-and-vector-borne-agents-in-dogs-and-cats-on-the-pine-ridge-reservation
#12
A Valeria Scorza, Michael R Lappin
The prevalence of intestinal parasites and vector-borne agents of dogs and cats in the Pine Ridge Reservation, South Dakota were determined. Fecal samples (84 dogs, 9 cats) were examined by centrifugal floatation and by immunofluorescence assay (FA) for Giardia and Cryptosporidium. PCR was performed on Giardia [beta-giardin (bg), triose phosphate isomerase (tpi), glutamate dehydrogenase genes (gdh)] and Cryptosporidium [heat shock protein-70 gene (hsp)] FA positive samples. Cat sera (n = 32) were tested for antibodies against Bartonella spp...
September 4, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29054323/human-kidney-stone-matrix-latent-potential-to-restrain-com-induced-cytotoxicity-and-inflammatory-response
#13
Shifa Narula, Simran Tandon, Prakash Baligar, Shrawan Kumar Singh, Chanderdeep Tandon
Kidney stone disease is a multi-factorial disorder resulting from the interplay of various risk factors including lifestyle, environment and genetics along with metabolic activities inside the body. However, it is difficult to determine how these factors converge to promote stone disease. Extensive investigations of kidney stone composition at the molecular level have been carried out however; its impact on the complex mechanism of stone formation is still obscure. Hence, an in vitro study was designed to investigate the attenuation of calcium oxalate toxicity by human kidney stone matrix proteins on NRK-52E cells using flowcytometry, Western blotting, RT-PCR and immunofluorescence assays...
October 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29048850/-stable-isotope-labeling-and-parallel-reaction-monitoring-based-proteomic-quantification-for-biomarker-screening-and-validation-of-hepatocellular-carcinoma
#14
Sulan Wang, Huaping Gao, Jing Zhang, Xiang Ye
Liver cancer is the fifth most common cancer with extremely low five year survival rate. Early diagnosis is of great importance for cancer therapy. In this work, stable isotope labeling-based relative quantitative proteomics and parallel reaction monitoring-based target proteomics were combined for cancer biomarker screening and validation. By using this strategy, 70 significantly changed proteins in hepatocellular carcinoma tissues were obtained, among which seven proteins were further validated. The validated proteins contain the clinically used hepatocellular carcinoma (HCC) biomarker alpha-fetoprotein (AFP) and the reported biomarker candidates Heat shock protein HSP 90-beta (HSP90), fatty acid-binding protein, epidermal (FABP5) and alcohol dehydrogenase 4 (ADH4), which demonstrated the robustness of the strategy...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29042071/influence-of-ginkgo-biloba-extract-egb-761-on-expression-of-il-1-beta-il-6-tnf-alfa-hsp-70-hsf-1-and-cox-2-after-noise-exposure-in-the-rat-cochlea
#15
Remzi Dogan, Alev Pektas Sjostrand, Alper Yenıgun, Ersin Karatas, Abdurrahim Kocyigit, Orhan Ozturan
OBJECTIVE: The objective of this study was to investigate the influence of Ginkgo Biloba in early treatment of noise induced hearing loss on expression of IL-6, IL-1 Beta, TNF-alfa, HSP-70, HSF-1 and COX-2 in the rat cochlea. METHODS: Thirty two female rats were randomly divided into four groups (Acoustic Trauma, Ginkgo Biloba, Acoustic Trauma+Ginkgo Biloba, Non Treatment). Auditory brainstem response (ABR) was applied in all the groups. At the end of the study, IL-1Beta, IL-6, TNF-alpha, HSP-70, HSF-1 and COX-2 were studied in cochlear tissue with ELISA and Western blot analysis...
October 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29040016/centella-asiatica-fraction-3-suppresses-the-nuclear-factor-erythroid-2-related-factor-2-anti-oxidant-pathway-and-enhances-reactive-oxygen-species-mediated-cell-death-in-cancerous-lung-a549-cells
#16
Dhaneshree Bestinee Naidoo, Alisa Phulukdaree, Krishnan Anand, Vikash Sewram, Anil Amichund Chuturgoon
Centella asiatica is a tropical medicinal plant that is commonly used in traditional medicine. Medicinal properties of C. asiatica include anti-oxidant, anti-inflammatory, and anti-cancer activity. We investigated the anti-oxidant and anti-proliferative/cytotoxic effects of a semi-purified fraction of C. asiatica ethanolic leaf extract (C3) in cancerous lung A549 cells. C3 was obtained by silica column fractionation and identified by using thin-layer chromatography and gas chromatography mass spectrometry. Cytotoxicity of C3 in A549 cells was evaluated (cell viability assay-WST-1; 24 h; [0...
October 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29034530/gene-expression-and-morphological-changes-in-the-intestinal-mucosa-associated-with-increased-permeability-induced-by-short-term-fasting-in-chickens
#17
S Gilani, G S Howarth, G Nattrass, S M Kitessa, R Barekatain, R E A Forder, C D Tran, R J Hughes
Short-term fasting for 4.5 and 9 hr has been demonstrated to increase intestinal permeability (IP) in chickens. This study aimed to investigate the effects of 0, 4.5, 9 and 19.5 hr fasting on intestinal gene expression and villus-crypt architecture of enterocytes in jejunal and ileal samples. On day 38, Ross-308 male birds were fasted according to their group and then euthanised. Two separate intestinal sections (each 2 cm long, jejunum and ileum) were collected. One section was utilised for villus height and crypt depth measurements...
October 16, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29034430/ultraviolet-filters-and-heat-shock-proteins-effects-in-chironomus-riparius-by-benzophenone-3-and-4-methylbenzylidene-camphor
#18
Raquel Martín-Folgar, Mónica Aquilino, Irene Ozáez, José-Luis Martínez-Guitarte
Benzophenone-3 (BP3) and 4-methylbenzylidene camphor (4MBC) are common ultraviolet filters (UV filters), compounds considered as emergent contaminants, used in different products like plastics and personal care products. The levels of these compounds are rising in the wild, but the effects they have on invertebrates are poorly understood. Chironomus riparius is a benthic insect widely used in toxicology, and several studies have been previously performed in our laboratory to determine the effects these compounds have on this organism at the molecular level...
October 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29017815/rna-polymerase-ii-pausing-and-transcriptional-regulation-of-the-hsp70-expression
#19
REVIEW
Heeyoun Bunch
Heat-shock proteins (HSPs) belong to the chaperone protein family whose expression is induced by different stresses including heat-shock. In response to the extracellular or intrinsic stimuli and stresses, HSPs play important roles in the maintenance of cellular homeostasis. HSP70, a major HSP protein (molecular weight, 70 KDa), regulates diverse cellular pathways including protein quality control, translation, immune response, and cancer survival. As a critical cellular defense system to minimize damages from cellular stresses, HSP70 expression and transcriptional activation are rapidly regulated, mainly through the action of a transcription activator, Heat shock factor 1 (HSF1)...
October 3, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28980718/identification-of-over-expressed-proteins-in-oral-submucous-fibrosis-by-proteomic-analysis
#20
Tapasi Das, Chandraday Prodhan, Santunu Patsa, Jay Gopal Ray, Keya Chaudhuri
Early detection and identification of oral pre-malignancy or malignancy help in management of the disease and improve survival rates. Oral submucous fibrosis (OSMF) is a major threat to public health worldwide and especially in Southeast Asian countries. Identification of biomarkers is a necessary step towards early diagnosis and treatment. In this study, differentially expressed proteins between oral submucous fibrotic tissue and normal control tissues were recorded by proteomic analysis using two dimensional electrophoresis (2DE) and MALDI TOF mass spectrometry...
October 5, 2017: Journal of Cellular Biochemistry
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