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https://www.readbyqxmd.com/read/29332272/comparative-study-of-selenium-and-selenium-nanoparticles-with-reference-to-acute-toxicity-biochemical-attributes-and-histopathological-response-in-fish
#1
Neeraj Kumar, Kishore Kumar Krishnani, Narendra Pratap Singh
Recent studies have demonstrated that selenium (Se) and selenium nanoparticles (Se-NPs) exhibited toxicity at a higher concentration. The lethal concentration of Se and Se-NPs was estimated as 5.29 and 3.97 mg/L at 96 h in Pangasius hypophthalmus. However, the effect of different definite concentration of Se (4.5, 5.0, 5.5, and 6.0 mg/L) and Se-NPs (2.5, 3.0, 3.5, and 4.0 mg/L) was decided for acute experiment. Selenium and Se-NPs alter the biochemical attributes such as anti-oxidative status [catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST) activities], neurotransmitter enzyme, cellular metabolic enzymes, stress marker, and histopathology of P...
January 13, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29307045/a-comparison-of-cell-survival-and-heat-shock-protein-expression-after-radiation-in-normal-dermal-fibroblasts-microvascular-endothelial-cells-and-different-head-and-neck-squamous-carcinoma-cell-lines
#2
Dominique Muschter, Fabian Geyer, Richard Bauer, Tobias Ettl, Stephan Schreml, Frank Haubner
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) shows increased radioresistance due to the manipulation of homeostatic mechanisms like the heat shock response. This study intended to comparatively analyze effects of ionizing radiation on different HNSCC cell lines (PCI) and normal human dermal fibroblasts (NHFs) and human dermal microvascular endothelial cells (HDMECs) to uncover differences in radiation coping strategies. MATERIALS AND METHODS: Proliferation (BrdU assay), apoptosis (caspase 3/7) and intracellular protein expression of heat shock protein (HSP)-70, and phosphorylated and total HSP27, determined by enzyme-linked immunosorbent assay (ELISA), were analyzed after exposure to increasing doses of ionizing radiation (2, 6, and 12 Gray, Gy)...
January 6, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29285052/suppression-of-alzheimer-s-disease-related-phenotypes-by-the-heat-shock-protein-70-inducer-geranylgeranylacetone-in-app-ps1-transgenic-mice-via-the-erk-p38-mapk-signaling-pathway
#3
Yuan Sun, Jiang-Rong Zhang, Shuyan Chen
HSP70 overexpression has a remedying effect in neurodegenerative diseases. In Alzheimer's disease (AD), the suppressive effects of HSP70 overexpression on AD-related phenotypes and the underlying mechanisms are unknown. In the current study, the effect of geranylgeranylacetone (GGA), a non-toxic inducer of heat shock protein (HSP)-70 expression, on cognitive function and other pathological phenotypes were evaluated in APP/PS1 mice. It was observed that all doses of orally administered GGA (200, 400, and 800 mg/kg/day) improved cognitive deficit (P<0...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29247830/brief-report-phase-2-study-of-the-hsp-90-inhibitor-auy922-in-previously-treated-and-molecularly-defined-patients-with-advanced-non-small-cell-lung-cancer
#4
Enriqueta Felip, Fabrice Barlesi, Benjamin Besse, Quincy Chu, Leena Gandhi, Sang-We Kim, Enric Carcereny, Lecia V Sequist, Paal Brunsvig, Christos Chouaid, Egbert F Smit, Harry J M Groen, Dong-Wan Kim, Keunchil Park, Emin Avsar, Sebastian Szpakowski, Mikhail Akimov, Edward B Garon
INTRODUCTION: In this phase 2 study, we evaluated the activity of AUY922 in pretreated stage IV NSCLC patients. METHODS: Patients with advanced NSCLC were divided into molecularly defined strata based on mutations in EGFR, ALK, KRAS, or wild-type for all three. All patients must have received > 2 prior lines of therapy, except a fifth stratum for less pretreated EGFR cohort (EGFR < 2). In EGFR mutant and ALK-rearranged strata, prior platinum therapy was not required...
December 13, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29227447/heat-shock-proteins-in-human-perilymph-implications-for-cochlear-implantation
#5
Heike Schmitt, Ariane Roemer, Carsten Zeilinger, Rolf Salcher, Martin Durisin, Hinrich Staecker, Thomas Lenarz, Athanasia Warnecke
OBJECTIVE: Biomarkers reflecting the etiology and pathophysiology of inner ear diseases are limited. Evaluation of proteins in the perilymph may improve our understanding of inner ear disease. Heat shock proteins (HSP) belong to a superfamily of stress proteins and promote refolding of denatured proteins. The aim of the study was to analyze HSP in human perilymph and to identify possible correlation with audiological and etiologic data. METHODS: Sampling of the perilymph was performed during cochlear implantation and vestibular schwannoma removal...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29214191/vascular-mechanotransduction-data-in-a-rodent-model-of-diabetes-pressure-induced-regulation-of-shp2-and-associated-signaling-in-the-rat-inferior-vena-cava
#6
Kevin M Rice, Nandini D P K Manne, Ravikumar Arvapalli, Gautam K Ginjupalli, Eric R Blough
The effect of diabetes on vascular mechano-transductive response is of great concern. Given the higher rate of vein graft failures associated with diabetes, understanding the multiple cellular and molecular events associated with vascular remodeling is of vital importance. This article represents data related to a study published in Cardiovascular Diabetology [1] (Rice et al., 2006) and Open Journal of Endocrine and Metabolic Diseases [2] (Rice et al., 2015) evaluating the effect of pressurization on rat inferior venae cavae (IVC)...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29212841/hyperbaric-oxygen-pretreatment-benefits-on-decompression-sickness-in-bama-pigs
#7
Long Qing, Hong-Jie Yi, Ye-Wei Wang, Quan Zhou, Dinesh K Ariyadewa, Wei-Gang Xu
Decompression sickness (DCS) occurs when ambient pressure severely reduces during diving and aviation. Hyperbaric oxygen (HBO) pretreatment has been proven to exert beneficial effects on DCS in rats via heat-shock proteins (HSPs). We hypothesize that HBO pretreatment will also reduce DCS via HSPs in swine models. In part 1, six swine were subjected to a session of HBO treatment. HSP 32, 60, 70 and 90 were detected, before and at 6, 12, 18, 24 and 30 h following exposure in lymphocytes. In part 2, another ten swine were randomly assigned into 2 groups, 5 in each...
December 6, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29209126/intestinal-parameters-of-oxidative-imbalance-in-celiac-adults-with-extraintestinal-manifestations
#8
Agnieszka Piatek-Guziewicz, Agata Ptak-Belowska, Magdalena Przybylska-Felus, Pawel Pasko, Pawel Zagrodzki, Tomasz Brzozowski, Tomasz Mach, Malgorzata Zwolinska-Wcislo
AIM: To evaluate selected intestinal parameters of oxidative stress, and antioxidant capacity in adult celiac disease patients with extraintestinal manifestations. METHODS: The study involved 85 adult patients divided into the following subgroups: (1) patients with newly diagnosed celiac disease (CD) (n = 7); (2) celiac patients not adhering to a gluten-free diet (GFD) (n = 22); (3) patients with CD on the GFD (n = 31); and (4) patients with functional disorders of the gastrointestinal tract, serving as controls (n = 25)...
November 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29208684/central-npy-y5-sub-receptor-partially-functions-as-a-mediator-of-npy-induced-hypothermia-and-affords-thermotolerance-in-heat-exposed-fasted-chicks
#9
Hatem M Eltahan, Mohammad A Bahry, Hui Yang, Guofeng Han, Linh T N Nguyen, Hiromi Ikeda, Mohamed N Ali, Khairy A Amber, Mitsuhiro Furuse, Vishwajit S Chowdhury
Exposure of chicks to a high ambient temperature (HT) has previously been shown to increase neuropeptide Y (NPY) mRNA expression in the brain. Furthermore, it was found that NPY has anti-stress functions in heat-exposed fasted chicks. The aim of the study was to reveal the role of central administration of NPY on thermotolerance ability and the induction of heat-shock protein (HSP) and NPY sub-receptors (NPYSRs) in fasted chicks with the contribution of plasma metabolite changes. Six- or seven-day-old chicks were centrally injected with 0 or 375 pmol of NPY and exposed to either HT (35 ± 1°C) or control thermoneutral temperature (CT: 30 ± 1°C) for 60 min while fasted...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29203952/effect-of-intra-tumoral-magnetic-nanoparticle-hyperthermia-and-viral-nanoparticle-immunogenicity-on-primary-and-metastatic-cancer
#10
P Jack Hoopes, Courtney M Mazur, Bjorn Osterberg, Ailin Song, David J Gladstone, Nicole F Steinmetz, Frank A Veliz, Alicea A Bursey, Robert J Wagner, Steven N Fiering
Although there is long association of medical hyperthermia and immune stimulation, the relative lack of a quantifiable and reproducible effect has limited the utility and advancement of this relationship in preclinical/clinical cancer and non-cancer settings. Recent cancer-based immune findings (immune checkpoint modulators etc.) including improved mechanistic understanding and biological tools now make it possible to modify and exploit the immune system to benefit conventional cancer treatments such as radiation and hyperthermia...
January 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29203951/hypo-fractionated-radiation-magnetic-nanoparticle-hyperthermia-and-a-viral-immunotherapy-treatment-of-spontaneous-canine-cancer
#11
P Jack Hoopes, Karen L Moodie, Alicia A Petryk, James D Petryk, Shawntel Sechrist, David J Gladstone, Nicole F Steinmetz, Frank A Veliz, Alicea A Bursey, Robert J Wagner, Ashish Rajan, Danielle Dugat, Margaret Crary-Burney, Steven N Fiering
It has recently been shown that cancer treatments such as radiation and hyperthermia, which have conventionally been viewed to have modest immune based anti-cancer effects, may, if used appropriately stimulate a significant and potentially effective local and systemic anti-cancer immune effect (abscopal effect) and improved prognosis. Using eight spontaneous canine cancers (2 oral melanoma, 3 oral amelioblastomas and 1 carcinomas), we have shown that hypofractionated radiation (6 x 6 Gy) and/or magnetic nanoparticle hyperthermia (2 X 43°C / 45 minutes) and/or an immunogenic virus-like nanoparticle (VLP, 2 x 200 μg) are capable of delivering a highly effective cancer treatment that includes an immunogenic component...
January 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29197065/exosomes-from-heat-stressed-tumor-cells-inhibit-tumor-growth-by-converting-regulatory-t-cells-to-th17-cells-via-il-6
#12
Danfeng Guo, Yinghu Chen, Shoujie Wang, Lei Yu, Yingying Shen, Haijun Zhong, Yunshan Yang
Exosomes derived from heat-stressed tumor cells (HS-TEXs), which contain abundant heat shock protein (HSP) 70, strongly induce antitumor immune responses. HSP70-induced interleukin-6 (IL-6) promotes IL-17 expression and causes rejection of established prostate tumors. However, it remains unclear whether HS-TEXs exhibit antitumor effects by converting regulatory T cells (Tregs) into Th17 cells. In this study, we found that compared with TEXs, HS-TEXs were more potent in stimulating secretion of IL-6 from dendritic cells...
December 2, 2017: Immunology
https://www.readbyqxmd.com/read/29192359/a-field-and-laboratory-study-of-the-responses-of-cytoprotection-and-osmoregulation-to-salinity-stress-in-mosquitofish-gambusia-affinis
#13
Jeng-Wei Tsai, Hon-Jung Liew, Jyun-Jiang Jhang, Shiou-Han Hung, Pei-Jie Meng, Ming-Yih Leu, Christopher Lim, Cheng-Hao Tang
The mosquitofish (Gambusia affinis) naturally inhabits freshwater (FW; 1-3‰) and seawater (SW; 28-33‰) ponds in constructed wetland. To explore the physiological status and molecular mechanisms for salinity adaptation of the mosquitofish, cytoprotective responses and osmoregulation were examined. In the field study, activation of protein quality control (PQC) mechanism through upregulation of the abundance of heat shock protein (HSP) 90 and 70 and ubiquitin-conjugated proteins was found in the mosquitofish gills from SW pond compared to the individuals of FW pond...
December 1, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29182760/expression-patterns-of-tnf%C3%AE-madcam1-and-stat3-in-intestinal-and-skin-manifestations-of-inflammatory-bowel-disease
#14
Stephan R Vavricka, Jose A Galván, Heather Dawson, Alex Soltermann, Luc Biedermann, Michael Scharl, Alain M Schoepfer, Gerhard Rogler, Mareike B Prinz Vavricka, Luigi Terracciano, Alexander Navarini, Inti Zlobec, Alessandro Lugli, Thomas Greuter
Background: Pathogenesis of cutaneous extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) remains elusive. Efficacy of anti-TNF agents suggests TNF-dependent mechanisms. The role of other biologics such as anti-integrins or JAK-inhibitors is not yet clear. Methods: We performed immunohistochemistry for TNFα, NFκB, STAT1/STAT3, MAdCAM1, CD20/68, caspase 3/9, IFNγ, Hsp-27/70 on 240 intestinal (55 controls, 185 IBD) and 64 skin biopsies (11 controls, 18 Erythema nodosum (EN), 13 Pyoderma gangenosum (PG), 22 psoriasis)...
November 22, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29175859/investigating-trehalose-synthesis-genes-after-cold-acclimation-in-the-antarctic-nematode-panagrolaimus-sp-daw1
#15
Anna C Seybold, David A Wharton, Michael A S Thorne, Craig J Marshall
Panagrolaimus sp. DAW1 is a freeze-tolerant Antarctic nematode which survives extensive intracellular ice formation. The molecular mechanisms of this extreme adaptation are still poorly understood. We recently showed that desiccation-enhanced RNAi-soaking can be used - in conjunction with qPCR - to screen for phenotypes associated with reduced expression of candidate genes in Panagrolaimus sp. DAW1. Here we present the use of this approach to investigate the role of trehalose synthesis genes in this remarkable organism...
November 24, 2017: Biology Open
https://www.readbyqxmd.com/read/29166568/camel-whey-protein-protects-lymphocytes-from-apoptosis-via-the-pi3k-akt-nf-%C3%AE%C2%BAb-atf-3-and-hsp-70-signaling-pathways-in-heat-stressed-male-mice
#16
Gamal Badr, Nancy K Ramadan, Hanem S Abdel-Tawab, Samia F Ahmed, Mohamed H Mahmoud
Heat stress (HS) is an environmental factor that depresses the immune systems mediating dysfunctional immune cells. Camel whey protein (CWP) can scavenge free radicals and enhance immunity. The present study investigated the impact of dietary supplementation with CWP on immune dysfunction induced by exposure to HS. Male mice (n = 45) were divided into three groups: control group; HS group; and HS mice that were orally administered CWP (HS+CWP group). The HS group exhibited elevated levels of reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) as well as a significant reduction in the IL-2 and IL-4 levels...
November 22, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29157281/identification-of-immunogenic-proteins-of-the-cysticercoid-of-hymenolepis-diminuta
#17
Anna Sulima, Justyna Bień, Kirsi Savijoki, Anu Näreaho, Rusłan Sałamatin, David Bruce Conn, Daniel Młocicki
BACKGROUND: A wide range of molecules are used by tapeworm metacestodes to establish successful infection in the hostile environment of the host. Reports indicating the proteins in the cestode-host interactions are limited predominantly to taeniids, with no previous data available for non-taeniid species. A non-taeniid, Hymenolepis diminuta, represents one of the most important model species in cestode biology and exhibits an exceptional developmental plasticity in its life-cycle, which involves two phylogenetically distant hosts, arthropod and vertebrate...
November 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29145236/protection-by-nitrite-against-the-ischemic-effects-induced-by-acute-myocardial-infarction-in-mice
#18
Yafei Wang, Xin Song, Xia Yue, Hong Su, Yuanliang Gu, Linda Bowman, Min Ding, Baobo Zou, Jinshun Zhao, Xialu Lin
OBJECTIVE: This research was aimed to investigate the correct dose of nitrite that would act as a protection against the ischemic effects induced by acute myocardial infarction (AMI). METHODS: Mice were randomly divided into a sham-operation group (sham), an AMI operation group (AMI), and a nitrite pretreatment+AMI operation group (N+AMI). Seven days before the AMI operation, mice in the N+AMI group were pretreated with sodium nitrite in drinking water. RESULTS: One week after the AMI operation, serum lactate dehydrogenase (LDH) and creatine kinase (CK) activities in both AMI and N+AMI group were significantly higher than those in the sham group, but there were no significant differences between AMI and N+AMI mice...
November 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29142970/cardiovascular-disease-biomarkers-and-supar-in-predicting-decline-in-renal-function-a-prospective-cohort-study
#19
Salim S Hayek, Yi-An Ko, Mosaab Awad, Hina Ahmed, Brandon Gray, Kareem Mohammed Hosny, Hiroshi Aida, Melissa J Tracy, Changli Wei, Sanja Sever, Jochen Reiser, Arshed A Quyyumi
Introduction: Soluble urokinase-type plasminogen activator receptor (suPAR) strongly predicts outcomes and incident chronic kidney disease (CKD) in patients with cardiovascular disease (CVD). Whether the association between suPAR and CKD is a reflection of its overall association with chronic inflammation and poor CVD outcomes is unclear. We examined whether CVD biomarkers, including high-sensitivity C-reactive protein (hs-CRP), fibrin-degradation products (FDPs), heat-shock protein 70 (HSP-70), and high-sensitivity troponin I (hs-TnI) were associated with a decline in kidney function in the Emory Cardiovascular Biobank cohort, in which suPAR levels were shown to be predictive of both incident CKD and CVD outcomes...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142172/change-in-redox-state-and-heat-shock-protein-expression-in-an-indian-major-carp-cirrhinus-cirrhosus-exposed-to-zinc-and-lead
#20
Mahammed Moniruzzaman, Puja Midday, Anindita Dhara, Debjit Das, Indranath Ghosal, Debosree Mukherjee, Suman Bhusan Chakraborty
Fish are exposed to different heavy metals that may induce numerous physiological changes. In the present study, we examined the redox state in response to a severe stress resulting from two heavy metals (Zinc and Lead) contamination in carp Cirrhinus cirrhosus. Fish were exposed to 1/10th of LC50 of the respective metals [zinc chloride (2.72 mg/L) and lead acetate (2.53 mg/L)] for 30 days and allowed to recover for another 30 days without any metal exposure. Concentration of metals, different enzymatic and non-enzymatic antioxidant agents and expression levels of heat shock protein (HSP) 70 and 90 were measured in the liver and the kidney of fish...
2017: Journal of Toxicological Sciences
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