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https://www.readbyqxmd.com/read/28716262/new-genetic-causes-for-complex-hereditary-spastic-paraplegia
#1
Paulo Victor Sgobbi de Souza, Thiago Bortholin, Renan Braido Dias, Marco Antônio Troccoli Chieia, Stênio Burlin, Fernando George Monteiro Naylor, Wladimir Bocca Vieira de Rezende Pinto, Acary Souza Bulle Oliveira
INTRODUCTION: Hereditary Spastic Paraplegia (HSP) represents a complex and heterogeneous group of rare neurodegenerative disorders that share a common clinical feature of weakness and lower limb spasticity that can occur alone or in combination with a constellation of other neurological or systemic signs and symptoms. Although the core clinical feature of weakness and lower limb spasticity is virtually universal, the genetic heterogeneity is almost uncountable with more than 70 genetic forms described so far...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28714586/activation-of-autophagy-is-involved-in-the-protective-effect-of-17%C3%AE-oestradiol-on-endotoxaemia-induced-multiple-organ-dysfunction-in-ovariectomized-rats
#2
Ming-Tzeung Chung, Yen-Mei Lee, Hsin-Hsueh Shen, Pao-Yun Cheng, Yu-Chen Huang, Yu-Ju Lin, Yu-Yang Huang, Kwok-Keung Lam
Oestrogens have been reported to attenuate acute inflammation in sepsis. In this study, the effects of long-term oestrogen replacement with 17β-oestradiol (E2 ) on endotoxaemia-induced circulatory dysfunction and multiple organ dysfunction syndrome were evaluated in ovariectomized (Ovx) rats. E2 (50 μg/kg, s.c., 3 times/week) was administered for 8 weeks, followed by the induction of endotoxaemia by intravenous infusion of lipopolysaccharides (LPS; 30 mg/kg/4 hrs). Oestrogen deficiency induced by ovariectomy for 9 weeks augmented the LPS-induced damage, including endotoxic shock, myocardial contractile dysfunction, renal dysfunction and rhabdomyolysis...
July 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28702872/dietary-supplementation-of-selenium-enriched-probiotics-enhances-meat-quality-of-broiler-chickens-gallus-gallus-domesticus-raised-under-high-ambient-temperature
#3
Alam Zeb Khan, Shahnawaz Kumbhar, Yunhuan Liu, Mohammad Hamid, Cuiling Pan, Sonia Agostinho Nido, Fahmida Parveen, Kehe Huang
We investigated the effects of selenium-enriched probiotics (SP) on broiler meat quality under high ambient temperature and explore their underlying mechanisms. A total of 200 1-day-old male broiler chicks (Ross 308) were randomly allotted to four treatment groups, each with five replicates, in groups of ten birds. These birds were fed a corn-soybean basal diet (C), a basal diet plus probiotics supplementation (P), a basal diet plus Se supplementation in the form of sodium selenite (SS, 0.30 mg Se/kg), and a basal diet with the addition of selenium-enriched probiotics (SP, 0...
July 12, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28693241/the-novel-immunomodulator-immunepotent-crp-combined-with-chemotherapy-agent-increased-the-rate-of-immunogenic-cell-death-and-prevented-melanoma-growth
#4
Maria Del Carmen Rodríguez-Salazar, Moises Armides Franco-Molina, Edgar Mendoza-Gamboa, Ana Carolina Martínez-Torres, Pablo Zapata-Benavides, Jose Sullivan López-González, Erika Evangelina Coronado-Cerda, Juan Manuel Alcocer-González, Reyes Silvestre Tamez-Guerra, Cristina Rodríguez-Padilla
Immunogenic cell death is a cell death modality that stimulates the immune system to combat cancer cells. IMMUNEPOTENT CRP (ICRP) is a mixture of substances of low molecular weight obtained from bovine spleens that exhibits in vitro cytotoxic activity on different tumor cell lines and modulates the immune response in vivo. The aim of the present study was to determine whether the cytotoxic effect of ICRP and its combination with oxaliplatin (OXP) on murine melanoma B16F10 cells was due to immunogenic cell death...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28677812/alanyl%C3%A2-glutamine-prophylactically-protects-against-lipopolysaccharide%C3%A2-induced-acute-lung-injury-by-enhancing-the-expression-of-hsp70
#5
Haitang Wang, Yinv Dong, Yehua Cai
At present, the timing of glutamine administration remains controversial. The aim of the present study was to confirm the early protective mechanisms of alanyl‑glutamine (Ala‑Gln) against lipopolysaccharide (LPS)‑induced lung injury, as well as to detect the best time for Ala‑Gln usage. A total of 60 adult Wistar rats were randomly divided into 6 groups: The control group (C), the LPS‑induced shock group (LPS), the pre‑Ala‑Gln treated group (A1) and the pre‑Gln treated group (G1), which separately received 4...
June 30, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28676379/effects-of-nutrient-and-water-restriction-on-thermal-tolerance-a-test-of-mechanisms-and-hypotheses
#6
Katherine A Mitchell, Leigh Boardman, Susana Clusella-Trullas, John S Terblanche
Nutritional deprivation or desiccation can influence thermal tolerance by impacting the insects' ability to evaporatively cool, maintain cell membrane integrity and conduct protective or repair processes. Recovery from chilling is also linked to the re-establishment of iono- and osmo-regulatory homeostasis. Here, using Mediterranean fruit fly (Ceratitis capitata, Diptera: Tephritidae), we manipulated water and nutrient availability to test the mechanistic expectation that changes in whole organism lipid and water content can elicit variation in cold or heat tolerance (scored as chill coma recovery time and heat knockdown time)...
July 1, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28672889/pharmacological-postconditioning-with-atorvastatin-calcium-attenuates-myocardial-ischemia-reperfusion-injury-in-diabetic-rats-by-phosphorylating-gsk3%C3%AE
#7
Linyan Chen, Ping Cai, Zhendong Cheng, Zaibao Zhang, Jun Fang
Diabetes is an independent risk factor for myocardial ischemia, and many epidemiological data and laboratory studies have revealed that diabetes significantly exacerbated myocardial ischemia/reperfusion injury and ameliorated protective effects. The present study aimed to determine whether pharmacological postconditioning with atorvastatin calcium lessened diabetic myocardial ischemia/reperfusion injury, and investigated the role of glycogen synthase kinase (GSK3β) in this. A total of 72 streptozotocin-induced diabetic rats were randomly divided into six groups, and 24 age-matched male non-diabetic Sprague-Dawley rats were randomly divided into two groups...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28655348/the-carbon-monoxide-releasing-molecule-alf-186-mediates-anti-inflammatory-and-neuroprotective-effects-via-the-soluble-guanylate-cyclase-%C3%A3-1-in-rats-retinal-ganglion-cells-after-ischemia-and-reperfusion-injury
#8
Felix Ulbrich, Claus Hagmann, Hartmut Buerkle, Carlos C Romao, Nils Schallner, Ulrich Goebel, Julia Biermann
BACKGROUND: The endogenously produced gaseous molecule carbon monoxide is able to promote organ protection after ischemia-reperfusion injuries (IRI). The impact of carbon monoxide releasing molecules (CORM) regarding inflammation in neuronal tissues has not been studied in detail. In this investigation, we aimed to analyze the effects of the CORM ALF-186 on neuro-inflammation and hypothesized that the soluble guanylate cyclase (sGC) is playing a decisive role. METHODS: Retinal ischemia-reperfusion injury was performed for 60 min in Sprague-Dawley rats...
June 27, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28653583/warm-and-humidified-versus-cold-and-dry-co2-pneumoperitoneum-in-minimally-invasive-colon-resection-a-randomized-controlled-trial
#9
Elie Sutton, Geoffrey Bellini, Michael J Grieco, H M C Shantha Kumara, Xiaohong Yan, Vesna Cekic, Linda Njoh, Richard L Whelan
INTRODUCTION: Peritoneal insufflation with warm-humidified (WH) CO2 gas during minimally invasive surgical procedures is purported to prevent hypothermia and peritoneal desiccation and is associated with decreased postoperative IL-6 levels. This randomized study's purpose was to determine the clinical impact of WH versus cold-dry (CD) CO2 in minimally invasive colon resection (MICR), and to assess perioperative plasma levels of IL-6, TIMP-1, sVEGF-R1, and HSP-70 after MICR. METHODS: Operative and short-term clinical data plus perioperative blood samples were collected on MICR patients randomized to receive either WH (36...
June 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28646803/effects-of-balneotherapy-on-serum-levels-of-shingosine-1-phosphate-in-patients-with-osteoarthritis
#10
Esra Aycan Ustyol, Fatih Karaarslan, Seldag Bekpinar, Kagan Ozkuk, Nergis Erdogan
Context • Balneotherapy is one of the most commonly used nonpharmacological interventions for osteoarthritis (OA), but its mechanism of action in relieving pain and stiffness and in improving physical function is not well understood. Studies have found that therapy provokes a series of neuroendocrinal reactions with anti-inflammatory and analgesic effects. Sphingosine-1-phosphate (S1P), a bioactive lipid, has been implicated as an important mediator in the maintenance of physiological processes (eg, vascular barrier integrity) and in pathophysiologic processes such as inflammatory conditions...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28632265/3d-printed-conformal-microfluidics-for-isolation-and-profiling-of-biomarkers-from-whole-organs
#11
Manjot Singh, Yuxin Tong, Kelly Webster, Ellen Cesewski, Alexander P Haring, Sahil Laheri, Bill Carswell, Timothy J O'Brien, Charles H Aardema, Ryan S Senger, John L Robertson, Blake N Johnson
The ability to interface microfluidic devices with native complex biological architectures, such as whole organs, has the potential to shift the paradigm for the study and analysis of biological tissue. Here, we show 3D printing can be used to fabricate bio-inspired conformal microfluidic devices that directly interface with the surface of whole organs. Structured-light scanning techniques enabled the 3D topographical matching of microfluidic device geometry to porcine kidney anatomy. Our studies show molecular species are spontaneously transferred from the organ cortex to the conformal microfluidic device in the presence of fluid flow through the organ-conforming microchannel...
June 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28627586/hsp70-acetylation-prevents-caspase-dependent-independent-apoptosis-and-autophagic-cell-death-in-cancer-cells
#12
Yoo Hoi Park, Ji Hae Seo, Ji-Hyeon Park, Hye Shin Lee, Kyu-Won Kim
Cancer cells are continuously challenged by adverse environmental factors including hypoxia, metabolite restriction, and immune reactions, and must adopt diverse strategies to survive. Heat shock protein (Hsp) 70 plays a central role in protection against stress-induced cell death by maintaining protein homeostasis and interfering with the process of programmed cell death. Recent findings have suggested that Hsp70 acetylation is a key regulatory modification required for its chaperone activity, but its relevance in the process of programmed cell death and the underlying mechanisms involved are not well understood...
June 12, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28624469/effects-of-protein-sources-on-growth-immunity-and-antioxidant-capacity-of-juvenile-pearl-oyster-pinctada-fucata-martensii
#13
Chuangye Yang, Ruijuan Hao, Yuewen Deng, Yongshan Liao, Qingheng Wang, Ruijiao Sun, Yu Jiao, Xiaodong Du
In this study, we formulated five diets, namely, P1, P2, P3, P4 and P5, with Chlorella sp. powder, Spirulina platensis powder, yeast powder, soybean meal and corn gluten, respectively, as major protein sources. A feeding experiment was designed to evaluate the effects of formulated diets on the growth performance, immunity and antioxidant and biomineralization capacity of juvenile pearl oyster (Pinctada fucata martensii). In the experiments, the five groups were separately fed with P1, P2, P3, P4 and P5 diets...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28618124/pir-823-contributes-to-colorectal-tumorigenesis-by-enhancing-the-transcriptional-activity-of-hsf1
#14
Jie Yin, Xiao-Yu Jiang, Wei Qi, Chen-Guang Ji, Xiao-Li Xie, Dong-Xuan Zhang, Zi-Jin Cui, Cun-Kai Wang, Yun Bai, Jia Wang, Hui-Qing Jiang
Piwi-interacting RNAs (piRNAs), a novel class of small non-coding RNA, were first discovered in germline cells and are thought to silence transposons in spermatogenesis. Recently, piRNAs have also been identified in somatic tissues, and aberrant expression of piRNAs in tumor tissues may be implicated in carcinogenesis. However, the function of piR-823 in colorectal cancer (CRC) remains unclear. Here, we first found that piR-823 was significantly up-regulated in CRC tissues compared with its expression in the adjacent tissues...
June 15, 2017: Cancer Science
https://www.readbyqxmd.com/read/28600176/molecular-characterization-and-expression-analysis-of-heat-shock-protein-70-and-90-from-hermetia-illucens-reared-in-a-food-waste-bioconversion-pilot-plant
#15
Alessia Giannetto, Sabrina Oliva, Lorenzo Mazza, Giovanni Mondello, Domenico Savastano, Angela Mauceri, Salvatore Fasulo
Two full-length cDNAs of heat shock protein (HSP) genes (Hihsp70 and Hihsp90) were cloned from the black soldier fly (BSF) Hermetia illucens larvae reared in a food waste bioconversion pilot plant. The Hihsp70 and Hihsp90 transcripts were 2243 and 2507bp long, contained 1923 and 2166bp open reading frames encoding proteins of 640 and 721 amino acids with a molecular mass of 69.8 and 83kDa, respectively. Comparative analysis of protein sequences revealed the presence of the conserved HSP motifs in both proteins, showing high homology to their counterparts in other insect species from six different orders...
June 6, 2017: Gene
https://www.readbyqxmd.com/read/28587230/aronia-melanocarpa-black-chokeberry-reduces-ethanol-induced-gastric-damage-via-regulation-of-hsp-70-nf-%C3%AE%C2%BAb-and-mcp-1-signaling
#16
Antonisamy Paulrayer, Aravinthan Adithan, Jeong Ho Lee, Kwang Hyun Moon, Dae Geun Kim, So Yeon Im, Chang-Won Kang, Nam Soo Kim, Jong-Hoon Kim
Aronia melanocarpa (Michx.) Ell. belongs to the Rosaceae family. The purpose of this study is to explore the gastroprotective effect of the Aronia melanocarpa hydro-alcoholic extract (AMHAE) against ethanol-induced gastric ulcer in a rat model. Different concentrations (50, 100, and 200 mg/kg) of AMHAE, or 30 mg/kg of omeprazole, significantly inhibited the gastric injury formation. The ethanol-induced ulcer group showed significant increases of malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor (TNF)-α, nuclear factor-kappaB p65 (NF-κB p65), and monocyte chemoattractant protein (MCP)-1, and decreased activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), and interleukin (IL)-4...
June 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28567063/a-review-of-case-and-case-series-reports-on-hen%C3%A3-ch-sch%C3%A3-nlein-syndrome-related-pancreatitis
#17
REVIEW
Fei Xiong, Yuhong Tao, Hong Li
To summarize the experience of diagnosing and treating patients with Henoch-Schönlein purpura (HSP)-related pancreatitis, a systematic review of previously published cases was conducted. Among 13 reported cases, there were six males and seven females whose age from 3 to 70 years. The clinical features of these patients indicated that acute pancreatitis could be the initial manifestation of HSP, the radiological change was atypical, and most cases were alleviated with steroidal treatment. Good outcomes can be achieved in patients who are diagnosed early with HSP-related pancreatitis, and it is vital to begin timely treatment of HSP-related pancreatitis with corticosteroid...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28559049/attenuation-of-thioacetamide-induced-hepatocellular-injury-by-short-term-repeated-injections-associated-with-down-regulation-of-metabolic-enzymes-and-relationship-with-mhc-class-ii-presenting-cells
#18
Mizuki Kuramochi, Takeshi Izawa, Munmun Pervin, Alexandra Bondoc, Mitsuru Kuwamura, Jonathan LaMarre, Jyoji Yamate
The liver is the primary organ participating in the metabolism of xenobiotics and is therefore an important target in the safety assessment of drugs, chemicals and environmental toxins. Drug-induced liver injury (DILI) has recently become widely recognized in human medicine as an adverse event. The progression of DILI often involves "damage-associated molecular patterns" (DAMPs) of gene and protein expression such as high-mobility group boxes (HMGBs), S100 proteins and heat shock proteins (Hsp). DAMPs are released from injured or necrotic cells and are bound to Toll-like receptors (TLRs) and modulate inflammatory reactions...
May 27, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28521848/impacts-of-stocking-density-on-development-and-puberty-attainment-of-replacement-beef-heifers
#19
K M Schubach, R F Cooke, A P Brandão, K D Lippolis, L G T Silva, R S Marques, D W Bohnert
In all, 60 Angus×Hereford heifers were ranked by age and BW (210±2 days and 220±2 kg) on day 0, and assigned to: (a) one of three drylot pens (10×14 m pens; 10 heifers/pen) resulting in a stocking density of 14 m2/heifer (HIDENS; n=3), or (b) one of three pastures (25 ha pastures; 10 heifers/pasture), resulting in a stocking density of 25 000 m2/heifer (LOWDENS; n=3). Pastures were harvested for hay before the beginning of this experiment, and negligible forage was available for grazing to LOWDENS heifers during the experiment (days 0 to 182)...
May 19, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28495509/cloning-of-three-heat-shock-protein-genes-hsp70-hsp90%C3%AE-and-hsp90%C3%AE-and-their-expressions-in-response-to-thermal-stress-in-loach-misgurnus-anguillicaudatus-fed-with-different-levels-of-vitamin-c
#20
Jie Yan, Xiao Liang, Yin Zhang, Yang Li, Xiaojuan Cao, Jian Gao
Heat shock protein 70 (HSP70) and 90 (HSP90) are the most broadly studied proteins in HSP families. They play key roles in cells as molecular chaperones, in response to stress conditions such as thermal stress. In this study, full-length cDNA sequences of HSP70, HSP90α and HSP90β from loach Misgurnus anguillicaudatus were cloned. The full-length cDNA of HSP70 in loach was 2332bp encoding 644 amino acids, while HSP90α and HSP90β were 2586bp and 2678bp in length, encoding 729 and 727 amino acids, respectively...
May 8, 2017: Fish & Shellfish Immunology
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