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Thyroid neoplasms

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https://www.readbyqxmd.com/read/28525424/metastatic-melanoma-with-papillary-features-a-mimic-and-possible-diagnostic-pitfall
#1
Alberto Valero-Torres, Victor G Prieto, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Michael T Tetzlaff, Jonathan L Curry, Doina Ivan, Phyu P Aung
Papillary and pseudopapillary features are histopathologic findings typically associated with carcinomas (thyroid, pancreas, breast, prostate, bladder, kidney, or ovary) or mesothelioma. Melanoma is typically composed of nested and variably pigmented atypical cells. Here, we report a case of in-transit metastasis of melanoma presenting with prominent papillary features, and we discuss the differential diagnoses of neoplasms with papillary features. This case report suggests that the spectrum of neoplasms with papillary features should be expanded to include melanoma, a pattern that, to the best of our knowledge, is uncommon...
June 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28521439/arteriovenous-malformation-and-thyroid-metastasis-from-underlying-renal-cell-carcinoma-an-unusual-presentation-of-malignancy-a-case-report
#2
H J Albandar, E S Roberto, J R H See, J H Sabiers
Renal Clear Cell Carcinoma (RCC) comprises over 80% of renal malignancies in adults. Thyroid gland metastasis is rare in RCC. Few studies have described cases of RCC mistaken for benign arteriovenous malformation (AVM). To the best of our knowledge, an AVM arising from underlying RCC metastasis to the brain has not yet been reported. The current study presents a case of RCC metastasis to the thyroid gland, with an AVM identified to be a result of metastatic involvement in the brain. A 45-year-old African-American female presented with left-sided weakness, slurred speech, facial droop and seizure...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28507839/issues-in-managing-hurthle-cell-carcinoma-of-thyroid-a-case-report
#3
Patricia Tai, Martin Korzeniowski, Evgeny Sadikov, Kurian Joseph, Angus Kirby, Jon Tonita, Aamer Mahmud
A 61-year-old woman noticed a right neck lump in October 2001. Fine needle aspiration showed follicular neoplasm, adenoma versus carcinoma. The ultrasound scan showed a solid mass of maximum dimension of 3.7 cm. She had a right thyroid lobectomy and isthmectomy in January 2002 (first surgery). The tissue specimen showed a 4.5 cm Hurthle cell carcinoma (HCC) with vascular invasion. There were no capsular invasion, extra-thyroidal extension, or margin involvement. A completion left lobectomy (second surgery) was performed two weeks later...
April 14, 2017: Curēus
https://www.readbyqxmd.com/read/28506419/radioguided-thyroidectomy-for-follicular-tumors-multicentric-experience
#4
D Parmeggiani, C Gambardella, R Patrone, A Polistena, M De Falco, R Ruggiero, R Cirocchi, A Sanguinetti, V Cuccurullo, M Accardo, N Avenia, G Docimo, S Tolone, V Bassi, L Docimo, G Conzo
BACKGROUND: The diagnosis of thyroid nodular diseases requires an integrated approach that has been widely established over the past years. This strategy includes: ultrasonography (US) with; implemented Color-Power-Doppler, conventional scintigraphy also with positive indicators, specific pathological studies targeted by immunohistochemically-assays, and the fine needle; aspiration biopsy (FNAB), which, usually, in case of "Follicular Lesions" (10-20%) findings is; unable to distinguish carcinoma from follicular adenoma, then indicating the necessity of surgery to; obtain a correct diagnosis...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28498291/multi-level-3d-printing-implant-for-reconstructing-cervical-spine-with-metastatic-papillary-thyroid-carcinoma
#5
Xiucan Li, Yiguo Wang, Yongfei Zhao, Jianheng Liu, Songhua Xiao, Keya Mao
STUDY DESIGN: A unique case report. OBJECTIVE: A three-dimensional (3D) printing technology is proposed for reconstructing multi-level cervical spine (C2-C4) after resection of metastatic papillary thyroid carcinoma in a middle-age female patient. SUMMARY OF BACKGROUND DATA: Papillary thyroid carcinoma is a malignant neoplasm with a relatively favorable prognosis. A metastatic lesion in multi-level cervical spine (C2-C4) destroys neurological functions and causes local instability...
May 11, 2017: Spine
https://www.readbyqxmd.com/read/28494807/concordant-clear-cell-mesonephric-carcinoma-of-the-bladder-and-lung-adenocarcinoma-with-clear-cell-features-multiple-primaries-versus-metastatic-neoplasms-a-case-report
#6
Sarmad H Jassim, Amer Khiyami, Jane K Nguyen, Santhi Ganesan, Joseph Tomashefski, Joram Sawady
BACKGROUND: Clear cell carcinoma of the bladder is a rare variant of urinary bladder adenocarcinoma. We report a case of a patient with clear cell carcinoma of the bladder and a concordant right upper lobe pulmonary adenocarcinoma with clear cell features, and we address the role of immunohistochemistry and cytogenetic analysis in distinguishing the two primary malignancies. CASE PRESENTATION: Our patient was a 59-year-old African American woman who presented with hematuria...
May 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28494523/korean-thyroid-imaging-reporting-and-data-system-features-of-follicular-thyroid-adenoma-and-carcinoma-a-single-center-study
#7
Jung Won Park, Dong Wook Kim, Donghyun Kim, Jin Wook Baek, Yoo Jin Lee, Hye Jin Baek
Purpose: This study aimed to assess the diagnostic efficacy of Korean Thyroid Imaging Reporting and Data System (K-TIRADS) features for distinguishing follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC). Methods: From January 2013 to July 2016, 46 follicular neoplasms in 45 patients who underwent preoperative thyroid ultrasonography (US) and thyroid surgery were included. The US features of each thyroid nodule were retrospectively evaluated by a single radiologist using a picture archiving and communication system...
April 13, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28489874/tafazzin-taz-promotes-the-tumorigenicity-of-cervical-cancer-cells-and-inhibits-apoptosis
#8
Mei Chen, Yuan Zhang, Peng-Sheng Zheng
Tafazzin (TAZ) is often aberrantly expressed in some cancers, including rectal cancer and thyroid neoplasms. However, the function of TAZ in cervical cancer cells remains unknown. This study aims to explore the expression and function of TAZ in cervical cancer cells. Here, we determined the expression of TAZ protein in normal cervical tissue (NC, n = 27), high-grade squamous intraepithelial lesions (HSIL, n = 26) and squamous cervical carcinoma (SCC, n = 41) by immunohistochemistry, the expression of TAZ protein gradually increased from NC to HSIL to SCC...
2017: PloS One
https://www.readbyqxmd.com/read/28488195/differences-in-clinical-features-between-subcategories-of-atypia-follicular-lesion-of-undetermined-significance
#9
Seong Dong Kim, Seung Hoon Han, Woo-Jin Jeong, Hyojin Kim, Soon Hyun Ahn
Within the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), category III (atypia or follicular lesion of undetermined significance (AUS/FLUS)) comprises specimens with heterogeneous features and the need for subcategorization has been reported. We compared the clinical features of two subgroups from within the category of AUS/FLUS to determine precise guidelines for clinicians who explain the results of fine-needle aspiration (FNA) to patients. Retrospective review was performed including data from all patients who underwent FNA with results reported as AUS/FLUS at a single tertiary hospital from January 2010 to August 2014...
May 9, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28486057/low-rate-of-niftp-in-asian-practice
#10
Andrey Bychkov, Mitsuyoshi Hirokawa, Chan Kwon Jung, Zhiyan Liu, Yun Zhu, Soon Won Hong, Shinya Satoh, Chiung-Ru Lai, Lien Huynh, Kennichi Kakudo
Reclassification of non-invasive encapsulated follicular variant of papillary thyroid carcinoma (EFV-PTC) into non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has significant impact for patients and clinicians. It was estimated that this reclassification could potentially affect more than 45,000 patients worldwide annually (around 20% of thyroid carcinoma), who will not be labeled as having cancer. Our experience from Asian grounds indicates that NIFTP is extremely rare in local practice...
May 9, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28480631/incidence-and-significance-of-true-papillae-in-thyroid-fine-needle-aspiration
#11
Andrew A Renshaw, Edwin W Gould
INTRODUCTION: Whether true papillae without nuclear features of papillary carcinoma in thyroid fine needle aspirates should be diagnosed as atypia of undetermined significance (AUS) is unclear. METHODS: The results of all thyroid FNAs performed from 2014-2016 with corresponding resections as well as aspirates from 2000-2016 with a diagnosis of follicular variant of papillary carcinoma or Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) were reviewed...
May 7, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28476125/performance-of-claims-based-algorithms-for-identifying-incident-thyroid-cancer-in-commercial-health-plan-enrollees-receiving-antidiabetic-drug-therapies
#12
Donnie Funch, Douglas Ross, Betsey M Gardstein, Heather S Norman, Lauren A Sanders, Atheline Major-Pedersen, Helge Gydesen, David D Dore
BACKGROUND: Thyroid cancer incidence is increasing in the United States (US) and many other countries. The objective of this study was to develop and evaluate algorithms using administrative medical claims data for identification of incident thyroid cancer. METHODS: This effort was part of a prospective cohort study of adults initiating therapy on antidiabetic drugs and used administrative data from a large commercial health insurer in the US. Patients had at least 6 months of continuous enrollment prior to initiation during 2009-2013, with follow-up through March, 2014 or until disenrollment...
May 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28474256/pediatric-imaging-in-dicer1-syndrome
#13
Marta Tijerin Bueno, Claudia Martínez-Ríos, Alejandro De la Puente Gregorio, Rayan A Ahyad, Anita Villani, Harriet Druker, Kalene van Engelen, Bailey Gallinger, Laura Aronoff, Ronald Grant, David Malkin, Mary-Louise C Greer
BACKGROUND: DICER1 syndrome, arising from a mutation in the DICER1 gene mapped to chromosome 14q32, is associated with an increased risk of a range of benign and malignant neoplasms. OBJECTIVE: To determine the spectrum of abnormalities and imaging characteristics in patients with DICER1 syndrome at a tertiary pediatric hospital. MATERIALS AND METHODS: This retrospective analysis evaluated imaging in patients ≤18 years with DICER1 germline variants between January 2004 and July 2016...
May 4, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28470939/expression-of-p16-ink4a-in-mixed-squamous-cell-and-glandular-papilloma-of-the-lung
#14
Ryo Miyoshi, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date
Mixed squamous cell and glandular papilloma (mixed papilloma) of the lung is an extremely rare neoplasm, with only 21 cases reported in the English literature. Although the expression of p16(Ink4a) has been analyzed in only two cases of mixed papilloma, they were negative for p16(Ink4a) . Therefore, the significance of p16(Ink4a) overexpression in mixed papilloma remains unclear. This is the first case of mixed papilloma with positive p16(Ink4a) expression in a 72-year-old male smoker. The 20 mm sized tumor was histologically diagnosed as mixed papilloma following right upper lobectomy...
May 3, 2017: Pathology International
https://www.readbyqxmd.com/read/28470780/intra-institutional-second-opinion-diagnosis-can-reduce-unnecessary-surgery-for-indeterminate-thyroid-fna-a-preliminary-report-on-34-cases
#15
C Bellevicine, I Migliatico, E Vigliar, N Serra, G Troncone
INTRODUCTION: Indeterminate diagnoses are rendered on 15%-30% of thyroid fine-needle aspirates (FNA). Thus, a second diagnostic opinion given by an outside expert pathologist is a common practice that facilitates a more appropriate clinical management. Conversely, the role of an intra-institutional second opinion diagnosis (iSOD), which is usually informally performed in-house, has not been well established. METHODS: To assess the contribution of iSOD, a retrospective series of 34 thyroid FNA diagnosed as follicular neoplasm/suspicious follicular neoplasm (FN/SFN) with matched histological follow-up and a malignancy rate of 17...
May 3, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28469731/integrated-data-analysis-reveals-potential-drivers-and-pathways-disrupted-by-dna-methylation-in-papillary-thyroid-carcinomas
#16
Caroline Moraes Beltrami, Mariana Bisarro Dos Reis, Mateus Camargo Barros-Filho, Fabio Albuquerque Marchi, Hellen Kuasne, Clóvis Antônio Lopes Pinto, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski, Silvia Regina Rogatto
BACKGROUND: Papillary thyroid carcinoma (PTC) is a common endocrine neoplasm with a recent increase in incidence in many countries. Although PTC has been explored by gene expression and DNA methylation studies, the regulatory mechanisms of the methylation on the gene expression was poorly clarified. In this study, DNA methylation profile (Illumina HumanMethylation 450K) of 41 PTC paired with non-neoplastic adjacent tissues (NT) was carried out to identify and contribute to the elucidation of the role of novel genic and intergenic regions beyond those described in the promoter and CpG islands (CGI)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28455835/surgical-approaches-in-hereditary-endocrine-tumors
#17
REVIEW
Maurizio Iacobone, Marilisa Citton, Giovanni Viel, Donatella Schiavone, Francesca Torresan
Endocrine tumors of thyroid, adrenal and parathyroid glands may be due to germline and inheritable mutations in 5-30% of patients. Medullary Thyroid Carcinoma, Pheochromocytoma, Paraganglioma, and Familial Primary Hyperparathyroidism are the most frequent entity. Hereditary endocrine tumors usually have a suggestive familial history; they occur earlier than sporadic variants, are multifocal, and have increased recurrence rates. They may be present as isolated variant or associated to other neoplasms in a syndromic setting...
April 28, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28454345/high-il-17-expression-is-associated-with-an-unfavorable-prognosis-in-thyroid-cancer
#18
Denise Faria Galano Carvalho, Bruna Riedo Zanetti, Lydianne Miranda, Marcela Kazue Hassumi-Fukasawa, Fabiana Miranda-Camargo, Janaína Cristiana Oliveira Crispim, Edson Garcia Soares
Previous studies have indicated that cancer may be promoted and/or exacerbated by inflammation and infection. The cytokines produced by activated innate immune cells that stimulate tumor growth and progression are considered as important components in this process. The interleukin (IL)-23/T helper (Th)17 axis, which exerts marked pro-inflammatory effects, has emerged as an important mediator in inflammation-associated cancer. Increasing clinical evidence indicates that Th17 may promote or inhibit tumor progression, however, the function of Th17 in the pathogenesis of benign and malignant thyroid neoplasms remains unclear...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453434/follicular-morphological-characteristics-may-be-associated-with-invasion-in-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features
#19
Nuray Can, Mehmet Celik, Yavuz Atakan Sezer, Filiz Ozyilmaz, Semra Ayturk, Ebru Tastekin, Necdet Sut, Hakan Gurkan, Funda Ustun, Buket Yilmaz Bulbul, Sibel Guldiken, Fulya Oz Puyan
The newly proposed nomenclature and diagnostic criteria for encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), the noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), could improve the consistency and accuracy of diagnosing this entity. Diagnosis of NIFTP requires evaluation of the complete tumor border or capsule. The presence of tumor invasion in follicular thyroid neoplasms with papillary-like nuclear features has been recently discussed by many authors...
April 28, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28450435/zuckerkandl-tubercle-of-the-thyroid-gland-correlations-between-findings-of-anatomic-dissections-and-ct-imaging
#20
H-J Won, H-S Won, D-S Kwak, J Jang, S-L Jung, I-B Kim
BACKGROUND AND PURPOSE: The Zuckerkandl tubercle is located at the posteromedial border of the thyroid lobe, and it may be confused with a neoplasm or other mass. This study was performed to clarify the position and morphologic characteristics of the Zuckerkandl tubercle by dissecting cadavers and to compare the findings with the corresponding CT images obtained in the same cadavers. MATERIALS AND METHODS: One hundred thyroid lobes from 50 fresh cadavers were dissected for this study (20 males and 30 females; mean age at death, 77...
April 27, 2017: AJNR. American Journal of Neuroradiology
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