keyword
https://read.qxmd.com/read/38534046/the-late-effects-of-haematopoietic-stem-cell-transplants-in-paediatric-patients-a-25-year-review
#1
JOURNAL ARTICLE
Samantha Lai-Ka Lee, Quynh-Nhu Nguyen, Cindy Ho, Simon James, Amreeta Kaur, Angelina Lim, Karin Tiedemann, Margaret Zacharin
CONTEXT: A rare, large single centre study covering all long-term health outcomes of paediatric allogeneic HSCT survivors, to provide comprehensive local data, and identify gaps and future directions for improved care. OBJECTIVE: To document endocrine sequelae and other late effects of all HSCT recipients. DESIGN: Retrospective review. SETTING: Royal Children's Hospital Melbourne. PATIENTS: 384 children and adolescents received HSCT...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38533762/laryngeal-paraganglioma-the-analysis-of-misdiagnosed-cases-and-literature-review
#2
REVIEW
Yi-Jun Dong, Hong-Hui Zhang, Jia-Qiao Liang, Ya-Ya Gao, Ming Xiong, Hui Yang
Laryngeal paraganglioma (LP) is an exceptionally rare neuroendocrine tumor, underscoring importance of accurate identification to preclude misdiagnoses. In this review, we presented two typical misdiagnosed LPs, and offered reviews of LP cases reported over the preceding decade and all documented misdiagnosed LP cases. Furthermore, we systematically investigated the underlying causes of misdiagnosis and elucidated key points for effective differentiation. A retrospective analysis of 28 LP cases revealed a predominant occurrence in middle-aged women, with an average history of 25...
March 27, 2024: Head & Neck
https://read.qxmd.com/read/38532234/stigma-risks-and-benefits-of-medicinal-cannabis-use-among-australians-with-cancer
#3
JOURNAL ARTICLE
Julia N Morris, Jessica Loyer, Jason Blunt
PURPOSE: People with cancer who use medicinal cannabis do so despite risks associated with limited clinical evidence, legalities, and stigma. This study investigated how Australians with cancer rationalise their medicinal cannabis use despite its risks. METHODS: Ten adults (5 males and 5 females; mean age of 53.3) who used cannabis medicinally for their cancer were interviewed in 2021-2022 about how they used and accessed the substance, attitudes and beliefs underpinning their use, and conversations with others about medicinal cannabis...
March 27, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38528648/a-component-of-high-grade-fetal-lung-adenocarcinoma-diagnosed-as-the-cause-of-lymph-node-metastasis
#4
Daichi Ishii, Satoshi Aoyama, Wataru Arai, Masaru Hasegawa, Akihiko Tanaka, Motoki Sakuraba
High-grade fetal lung adenocarcinoma (H-FLAC) is a rare type of tumor. There have been no reports demonstrating the degree of metastatic susceptibility of this tumor type. In this report, we describe a case in which 15% of the adenocarcinoma components were H-FLAC diagnosed as the cause of lymph node metastasis. A 75-year-old man presented with suspected primary lung cancer (clinical stage IIA, T2bN0M0) and underwent left upper lobectomy and superior mediastinal lymph node dissection. Postoperative histopathology revealed lung cancer with only lobar bronchial lymph node (#11) metastasis...
March 25, 2024: Thoracic Cancer
https://read.qxmd.com/read/38527098/illness-perception-and-benefit-finding-of-thyroid-cancer-survivors-a-chain-mediating-model-of-sense-of-coherence-and-self-disclosure
#5
JOURNAL ARTICLE
Xu Zhang, Tingting Huang, Di Sun, Meishuo Liu, Zhiwen Wang
BACKGROUND: Benefit finding is gaining attention as a strong predictor of quality of life, but few studies have addressed the mechanisms of its development. OBJECTIVE: The purpose of this study was to determine the relationship between illness perception and benefit finding in female thyroid cancer survivors and to further elucidate the mechanisms by which illness perception contributes to benefit finding through sense of coherence and self-disclosure. METHODS: A total of 280 female thyroid cancer survivors completed the questionnaire between January and August 2023...
March 25, 2024: Cancer Nursing
https://read.qxmd.com/read/38522950/influence-of-cancer-in-pregnancy-on-obstetric-and-neonatal-outcomes-an-observational-retrospective-cohort-study
#6
JOURNAL ARTICLE
Xuan Huang, Chen Zhang, Jialei Zhu, Yueyan Li, Jing Tang
OBJECTIVE: The study aimed to review the oncological characteristics and treatment of pregnancy-associated cancers and analyze the obstetric and neonatal outcomes to provide evidence-based recommendations for reproductive function preservation, oncological treatment, and obstetric management. METHODS: We conducted an observational retrospective cohort study among pregnant patients with cancer in 7 Chinese tertiary A hospitals from 2003 to 2021. We conducted multiple logistic regression to determine the influence of various factors on preterm birth and small-for-gestational-age infants, log-binomial regression to analyze temporal changes, and χ² tests to explore the effects of cancer type/treatment...
March 11, 2024: Journal of Gynecologic Oncology
https://read.qxmd.com/read/38521968/the-effects-of-aurora-kinase-inhibition-on-thyroid-cancer-growth-and-sensitivity-to-mapk-directed-therapies
#7
JOURNAL ARTICLE
Hannah M Hicks, Veronica L Nassar, Jane Lund, Madison M Rose, Rebecca E Schweppe
Thyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in BRAF are common in thyroid cancer, advanced PTC patients currently lack therapeutic options targeting the MAPK pathway, and despite the approved combination of BRAF and MEK1/2 inhibition for BRAF- mutant ATC, resistance often occurs. Here, we assess growth and signaling responses to combined BRAF and MEK1/2 inhibition in a panel of BRAF- mutant thyroid cancer cell lines. We first showed that combined BRAF and MEK1/2 inhibition synergistically inhibits cell growth in four out of six of the - BRAF -mutant thyroid cancer cell lines tested...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38517462/cancer-screening-with-multicancer-detection-tests-a-translational-science-review
#8
REVIEW
Wendy S Rubinstein, Christos Patriotis, Anthony Dickherber, Paul K J Han, Hormuzd A Katki, Elyse LeeVan, Paul F Pinsky, Philip C Prorok, Amanda L Skarlupka, Sarah M Temkin, Philip E Castle, Lori M Minasian
Multicancer detection (MCD) tests use a single, easily obtainable biospecimen, such as blood, to screen for more than one cancer concurrently. MCD tests can potentially be used to improve early cancer detection, including cancers that currently lack effective screening methods. However, these tests have unknown and unquantified benefits and harms. MCD tests differ from conventional cancer screening tests in that the organ responsible for a positive test is unknown, and a broad diagnostic workup may be necessary to confirm the location and type of underlying cancer...
March 22, 2024: CA: a Cancer Journal for Clinicians
https://read.qxmd.com/read/38516681/association-between-different-regional-lymph-node-metastases-of-papillary-thyroid-carcinoma-in-adolescents-and-young-adults
#9
JOURNAL ARTICLE
Lili Wang, Yahua Zheng, Yingpeng Ye, Zhekang Jiang, Jinling Lu, Gaoxiang Chen
Adolescents and young adults (AYA) describe the demographic aged between 15-39 years diagnosed with cancer. This group is particularly at risk of papillary thyroid carcinoma (PTC) with a greater severity compared with other ages. Through comparative design, the present study aimed to quantify central lymph node metastasis (CLNM) risk in AYAs. A total of 463 AYA patients with PTC and 489 patients >39 years old with PTC from Ningbo Medical Center Lihuili Hospital (Ningbo, China) were enrolled. Details such as demographic data, serum indices and fine-needle aspiration from the Electronic Medical Records System were extracted and analyzed...
May 2024: Oncology Letters
https://read.qxmd.com/read/38515205/giant-cell-tumor-of-soft-tissue-involving-thyroid-gland-a-case-report-and-review-of-the%C3%A2-literature
#10
JOURNAL ARTICLE
Jianrong Chen, Haiyong Zhang, Xiufang Li, Mengjun Hu, Xiaomin Dai
BACKGROUND: Giant cell tumor of soft tissue is a low malignant uncommon neoplasm, with histologic features and immunophenotype similar to its bone counterpart. Primary giant cell tumor of soft tissue in the thyroid gland is considered an exceedingly rare entity. CASE PRESENTATION: We describe a case of primary thyroid giant cell tumor of soft tissue in a 69-year-old Chinese female patient. Neck ultrasonography showed a 19 mm × 12 mm × 5 mm nodule with heterogeneous echo and clear boundary located within the left thyroid...
March 22, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38511027/a-nationwide-survey-to-assess-the-practices-and-patterns-of-use-of-intraoperative-nerve-monitoring-during-thyroid-surgery-among-surgeons-in-india
#11
JOURNAL ARTICLE
Parthiban Velayutham, Shivakumar Thiagarajan, Harsh Dhar, Nithyanad Chidambaranathan, Abhishek Vaidya, Kantamani Teja
UNLABELLED: There is still equipoise for the routine use of intraoperative nerve monitoring (IONM) for thyroid surgeries; however, some surgeons tend to use it for various reasons. In our study, we did a national survey to assess the patterns and practice of the use of IONM among surgeons during thyroid surgery in India. A questionnaire survey was sent to surgeons (head and neck surgical oncologists, general surgical oncologists, endocrine surgeons and otolaryngologists) in different zones in India via email, and their responses were analysed...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38509603/the-potential-value-of-ultrasound-in-predicting-local-refractory-relapse-events-in-primary-thyroid-lymphoma-patients
#12
JOURNAL ARTICLE
Jiang Ji, Luying Gao, Ruifeng Liu, Xinlong Shi, Liyuan Ma, Aonan Pan, Naishi Li, Chunhao Liu, Xiaoyi Li, Meng Yang, Yu Xia, Yuxin Jiang
BACKGROUND: Primary thyroid lymphoma (PTL) is a rare malignant disorder, and ultrasound plays an important role in PTL diagnosis and follow-up surveillance. Prediction of refractory/relapse events in PTL patients is an essential issue, yet no ultrasonic PTL features have been discovered to be related to refractory/local relapse events. METHODS: From January 2008 to September 2022, newly diagnosed PTL patients in our center who underwent standard first-line treatment and received an ultrasound examination before treatment were enrolled...
March 20, 2024: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://read.qxmd.com/read/38509485/imprinted-gene-detection-effectively-improves-the-diagnostic-accuracy-for-papillary-thyroid-carcinoma
#13
JOURNAL ARTICLE
Yanwei Chen, Ming Yin, Yifeng Zhang, Ning Zhou, Shuangshuang Zhao, Hongqing Yin, Jun Shao, Xin Min, Baoding Chen
BACKGROUND: Papillary thyroid carcinoma (PTC) is the most frequent histological type of thyroid carcinoma. Although an increasing number of diagnostic methods have recently been developed, the diagnosis of a few nodules is still unsatisfactory. Therefore, the present study aimed to develop and validate a comprehensive prediction model to optimize the diagnosis of PTC. METHODS: A total of 152 thyroid nodules that were evaluated by postoperative pathological examination were included in the development and validation cohorts recruited from two centres between August 2019 and February 2022...
March 20, 2024: BMC Cancer
https://read.qxmd.com/read/38508395/cxcl9-mediating-the-effect-of-thyroid-disorders-on-oral-and-oropharyngeal-cancer-risk-a-mediation-mendelian-randomization-study
#14
JOURNAL ARTICLE
Tao Zheng, Chengyong Liu, Rong Zhou, Xuan Zhu, Zibing Zhu, Yisi Tan, Jin Tan, Keke Zhu
INTRODUCTION: The established association between thyroid disorders (TD) and its two main subtypes-hyperthyroidism and hypothyroidism-and the incidence of oral and oropharyngeal cancer (OCPC) has been substantiated. However, the direct causal relationship and potential intermediary mechanisms linking these conditions have not been clearly defined in prior studies. MATERIAL & METHODS: This study employed univariate Mendelian randomization (MR) analysis to explore those relationship...
March 18, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38501238/survival-predictors-of-radioiodine-refractory-differentiated-thyroid-cancer-treated-with-lenvatinib-in-the-real-life
#15
JOURNAL ARTICLE
Vincenzo Marotta, Domenico Rocco, Anna Crocco, Maria Grazia Deiana, Ruggero Martinelli, Francesca Di Gennaro, Mariafelicia Valeriani, Luca Valvano, Alessia Caleo, Luciano Pezzullo, Antongiulio Faggiano, Mario Vitale, Salvatore Monti
CONTEXT: Lenvatinib is approved for the treatment of radioiodine-refractory differentiated thyroid cancer (RR-DTC). The definition of predictive factors of survival is incomplete. OBJECTIVE: To identify pre- and post- treatment survival predictors in a real-life cohort of RR-DTC treated with lenvatinib. DESIGN: Multicenter, retrospective, cohort study. SETTING: Three Italian thyroid cancer referral centers. PARTECIPANTS: 55 RR-DTC treated with lenvatinib...
March 19, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38498126/somatostatin-receptor-imaging-of-thyroid-tissue-and-differentiated-thyroid-cancer-using-gallium-68-labeled-radiotracers-a-review-of-clinical-studies
#16
REVIEW
Reza Pishdad, Giorgio Treglia, Ami Mehta, Prasanna Santhanam
INTRODUCTION: The rise in thyroid cancer incidence, especially papillary thyroid cancer (PTC), has underscored the need for improved diagnostic methods and management strategies. Herein, we aim to comprehensively review the evolving landscape in thyroid cancer diagnosis and the potential utility of Gallium-68 (Ga-68) based somatostatin receptor imaging. METHODS: We reviewed the clinical studies involving Ga-68 based radiotracers by looking at the following literature databases -PUBMED, EMBASE, WEB OF SCIENCE and COCHRANE...
March 18, 2024: Endocrine
https://read.qxmd.com/read/38497372/modifiable-risk-factors-for-thyroid-cancer-lifestyle-and-residence-environment
#17
JOURNAL ARTICLE
Yi Shen, Xian Wang, Lu Wang, Dandan Xiong, Cailian Wu, Liting Cen, Lianguang Xie, Xiangzhi Li
In recent years, there has been a rapid increase in the prevalence of benign and malignant tumours of the thyroid gland worldwide, positioning it as one of the most prevalent neoplasms within the endocrine system. While the pathogenesis of thyroid tumours is still unclear, an increasing number of studies have found that certain lifestyle and residence environments are associated with their occurrence and development. This article endeavours to elucidate the correlation between lifestyle, residential environment, and the increased prevalence of thyroid cancer in recent years...
March 18, 2024: Endokrynologia Polska
https://read.qxmd.com/read/38496753/renal-cell-oncocytoma-tumor-evolutions-a-case-report
#18
Alaa Khalid Alduraibi, Noora Bin Essa, Jamshed Bomanji
This report delineates the clinical progression of a renal oncocytoma in a 38-year-old female, initially asymptomatic, over a three-year follow-up period following her treatment for papillary thyroid cancer. The timeline of this case is as follows: In 2016, the patient was treated with total thyroidectomy and I131 for thyroid cancer. During an annual follow-up, an incidental renal mass was detected via FDG PET/CT, initially characterized as a benign, non-FDG-avid renal oncocytoma. Over two years, this lesion demonstrated a remarkable increase in FDG uptake and a slight growth in size, coupled with new I131 uptake in subsequent scans...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38495495/prognostic-significance-of-kif-12-functioning-as-a-tumour-suppressor-in-papillary-thyroid-carcinoma
#19
JOURNAL ARTICLE
Luying Gao, Ruifeng Liu, Yu Xia, Aonan Pan, Xinlong Shi, Liyuan Ma, Jiang Ji, Ya Hu, Xiaoyi Li, Yuang An, Nengwen Luo, Zhiyong Liang, Liangrui Zhou, Yuxin Jiang
Objective: To explore the potential value of a novel marker, KIF-12, in the progression and prognosis of papillary thyroid carcinoma (PTC) through integrative bioinformatics analysis, and clinical sample validation of the prognostic value of KIF-12. Materials and Methods: We extracted the clinicopathological data of 502 PTC patients from The Cancer Genome Atlas-Thyroid Cancer (TCGA-THCA) dataset to identify reliable differentially expressed genes (DEGs) between high and low KIF12 expression groups. Functional enrichment analysis was performed on upregulated DEGs...
2024: Journal of Cancer
https://read.qxmd.com/read/38491836/cancer-incidence-among-armenians-in-california
#20
JOURNAL ARTICLE
Ani S Movsisyan Vernon, Jeffrey S Hoch, Laura Fejerman, Theresa H Keegan
INTRODUCTION: California is home to the largest population of Armenians in the United States. The historical categorization of Armenians as 'White' or 'Some Other Race' in population databases has likely masked cancer incidence patterns in this population. This is the first study considering cancer incidence among Armenians in California. METHODS: We used the Armenian Surname List and birthplace information in the California Cancer Registry to identify Armenians with cancer diagnosed during 1988-2019...
March 2024: Cancer Medicine
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