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https://www.readbyqxmd.com/read/28720378/a-novel-technique-carbon-dioxide-gas-assisted-total-peritonectomy-diaphragm-and-intestinal-meso-stripping-in-open-surgery-for-advanced-ovarian-cancer-%C3%A3-ukurova-technique
#1
Ghanim Khatib, Ahmet Baris Guzel, Umran Kucukgoz Gulec, Mehmet Ali Vardar
OBJECTIVE: Most of the ovarian cancers are diagnosed at advanced stages. As peritoneal carcinomatosis increases, especially when it extends to the diaphragm and intestinal mesos, probability of obtaining complete cytoreduction is reduced. Complete cytoreduction (residue zero: R0) is one of the main factors affecting survival [1-3]. Here we present a novel technique of stripping the peritoneal surfaces as a part of cytoreductive surgery in such cases. METHODS: A 55year-old woman diagnosed with peritoneal carcinomatosis was considered appropriate for primary cytoreduction after assessment of her thorax-abdominopelvic tomography, which revealed resectable intra-abdominal disease...
July 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28694132/inflammatory-bowel-disease-and-small-bowel-cancer-risk-clinical-characteristics-and-histopathology-a-population-based-study
#2
Rasmus Dahlin Bojesen, Lene Buhl Riis, Estrid Høgdall, Ole Haagen Nielsen, Tine Jess
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) may increase risk of small bowel cancer (SBC). However, little is known of the characteristics and features of IBD-SBC, due to a low number of cases worldwide. We performed a population-based study of IBD and SBC to calculate risk and increase our understanding of clinical characteristics and histopathological and molecular features. METHODS: The study population consisted of all individuals 16 years or older living in Denmark during 1978-2010...
July 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28693151/application-of-small-intestine-decompression-combined-with-oral-feeding-in-middle-and-late-period-of-malignant-small-bowel-obstruction
#3
Dechun Li, Hongtao Du, Guoqing Shao, Yongtuan Guo, Wan Lu, Ruihong Li
The application value of small intestine decompression combined with oral feeding in the middle and late period of malignant small bowel obstruction was examined. A total of 22 patients with advanced malignant small bowel obstruction were included in the present study. An ileus tube was inserted via the nose under fluoroscopy into the obstructed small intestine of each patient. At the same time, the insertion depth the of the catheter was adjusted. When the catheter was blocked, small bowel selective angiography was performed to determine the location and cause of the obstruction and the extent of the obstruction, and to determine the length of the small intestine in the site of obstruction, and to select the variety and tolerance of enteral nutrition...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28689230/the-extended-transnasal-transsphenoidal-approach-for-anterior-skull-base-meningioma-considerations-in-patient-selection
#4
Joseph P Castlen, David J Cote, Hasan A Zaidi, Edward R Laws
PURPOSE: In this study, we set out to define our institutional criteria for patient eligibility for transsphenoidal resection of parasellar meningiomas, and to report our experience with extended transnasal approaches for these lesions. We aimed to discuss the important considerations of patient selection and risk stratification to optimize outcomes for patients with these difficult lesions, and also include considerations that should be reviewed during surgical approach selection. METHODS: Medical records from Brigham and Women's Hospital were retrospectively reviewed for all patients who underwent transsphenoidal surgery for pituitary disease with the senior author from April 2008 to March 2017 (938 procedures)...
July 8, 2017: Pituitary
https://www.readbyqxmd.com/read/28677983/aronia-berry-extract-ameliorates-the-severity-of-dextran-sodium-sulfate-induced-ulcerative-colitis-in-mice
#5
Sa-Haeng Kang, Yong-Deok Jeon, Kwang-Hyun Moon, Jeong-Ho Lee, Dae-Geun Kim, Wook Kim, Hyun Myung, Jong-Sung Kim, Hyun-Ju Kim, Keuk-Soo Bang, Jong-Sik Jin
Inflammatory bowel disease, including Crohn's disease and ulcerative colitis (UC), is a group of inflammatory conditions of the colon and small intestine. UC is a chronic inflammatory disorder of the colon and rectum that includes intervals of acute exacerbation. Although recent studies have suggested that proinflammatory cytokines might have initiated the inflammatory responses in UC, its etiology remains unclear. Aronia berries are rich in dietary polyphenols such as phenolic acids, anthocyanins, flavonoids, and proanthocyanidins with various health benefits, including antioxidant, anti-inflammatory, and antiaging activities...
July 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28676999/gastrointestinal-tract-complications-after-hepatic-radiofrequency-ablation-ct-prediction-for-major-complications
#6
Yun Soo Jeong, Se Hyung Kim, Jeong Min Lee, Jae Young Lee, Jung Hoon Kim, Dong Ho Lee, Hyo-Jin Kang, Chang Jin Yoon, Joon Koo Han
PURPOSE: To analyze CT features that predict major gastrointestinal tract (GIT) complication after hepatic radiofrequency ablation (RFA). MATERIALS AND METHODS: Of 3933 patients who underwent RFA for hepatic malignancy from January 2005 to September 2016, 52 patients (1.32%) who had GIT complications were retrospectively enrolled. Electronic medical records and CT results were reviewed for location (left vs. right lobe, subcapsular vs. non-subcapsular) and tumor size, distance from the hepatic capsule, number and length of needles, ablation time, presence of artificial ascites, previous history of percutaneous treatment or operation, injured organs, length and thickness of injured GIT, presence of adjacent infiltration, ascites, mucosal discontinuity, and free air, and eccentricity...
July 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28673658/long-term-hepatotoxicity-of-yttrium-90-radioembolization-as-treatment-of-metastatic-neuroendocrine-tumor-to%C3%A2-the%C3%A2-liver
#7
Yu-Kai Su, Rosewell V Mackey, Ahsun Riaz, Vanessa L Gates, Al B Benson, Frank H Miller, Vahid Yaghmai, Ahmed Gabr, Riad Salem, Robert J Lewandowski
PURPOSE: To determine long-term hepatotoxicity of yttrium-90 ((90)Y) radioembolization in patients treated for metastatic neuroendocrine tumor (mNET) and evaluate if imaging and laboratory findings of cirrhosis-like morphology are associated with clinical symptoms. MATERIALS AND METHODS: Retrospective review from 2003 to 2016 was performed for patients with mNET treated with (90)Y glass microspheres. Fifty-four patients with > 2 year follow-up were stratified into unilobar (n = 15) vs whole-liver (n = 39) treatment...
June 30, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28670610/in-vivo-characterization-of-abnormalities-in-small-bowel-diseases-using-probe-based-confocal-laser-endomicroscopy
#8
Naoki Ohmiya, Noriyuki Horiguchi, Tomomitsu Tahara, Mitsuo Nagasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Makoto Kuroda
BACKGROUND AND STUDY AIMS:  Probe-based confocal laser endomicroscopy (pCLE) enables real-time optical biopsy. Little is known about pCLE imaging deep inside the small bowel, therefore the aim of this study was to determine its usefulness. PATIENTS AND METHODS:  Between April 2014 and January 2016, we performed 38 pCLE examinations during double-balloon enteroscopy with intravenous fluorescein in 37 patients with: tumors (n = 10), vascular disorders (n = 6), inflammatory diseases and drug injuries (n = 13), other disorders (n = 4), and normal findings (n = 4)...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28670597/solitary-polypoid-angiodysplastic-lesion-mimicking-a-tumor-in-the-jejunum
#9
Abhishek D Polavarapu, Mayurathan Kesavan, Vivek V Gumaste, Monika Wrzolek, Elias Purow
Small bowel bleeding should be considered in patients with overt or occult gastrointestinal hemorrhage after normal upper and lower endoscopic examination. Angiodysplasia appearing as multiple flat vascular tufts is the most common cause of small bowel bleeding in patients over 40 years old. Polypoid angiodysplasia, however, is extremely rare. This report illustrates a unique case of solitary polypoid angiodysplasia in the jejunum of an adult with chronic kidney disease, who presented with an occult gastrointestinal bleed...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28664941/small-bowel-carcinomas-in-celiac-or-crohn-s-disease-distinctive-histophenotypic-molecular-and-histogenetic-patterns
#10
Alessandro Vanoli, Antonio Di Sabatino, Michele Martino, Catherine Klersy, Federica Grillo, Claudia Mescoli, Gabriella Nesi, Umberto Volta, Daniele Fornino, Ombretta Luinetti, Paolo Fociani, Vincenzo Villanacci, Francesco P D'Armiento, Renato Cannizzaro, Giovanni Latella, Carolina Ciacci, Livia Biancone, Marco Paulli, Fausto Sessa, Massimo Rugge, Roberto Fiocca, Gino R Corazza, Enrico Solcia
Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Two small bowel carcinoma subsets may arise in distinct immune-inflammatory diseases (celiac disease and Crohn's disease) and have been recently suggested to differ in prognosis, celiac disease-associated carcinoma cases showing a better outcome, possibly due to their higher DNA microsatellite instability and tumor-infiltrating T lymphocytes. In this study, we investigated the histological structure (glandular vs diffuse/poorly cohesive, mixed or solid), cell phenotype (intestinal vs gastric/pancreatobiliary duct type) and Wnt signaling activation (β-catenin and/or SOX-9 nuclear expression) in a series of 26 celiac disease-associated small bowel carcinoma, 25 Crohn's disease-associated small bowel carcinoma and 25 sporadic small bowel carcinoma cases, searching for new prognostic parameters...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28664384/a-case-of-protein-losing-enteropathy-caused-by-sclerosing-mesenteritis-diagnosed-with-capsule-endoscopy-and-double-balloon-endoscopy
#11
Yasushi Saito, Katsushi Hiramatsu, Takuto Nosaka, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Tomoyuki Nemoto, Yoshiaki Imamura, Yasunari Nakamoto
A 75-year-old man presented with abdominal distension, hypoproteinemia, ascites and a 35-mm mass in the small bowel mesentery. Laparotomy was performed, and he was diagnosed with sclerosing mesenteritis. His clinical condition improved, with computed tomography (CT) showing tumor shrinkage and decreasing ascites after administration of prednisolone; however, on drug withdrawal, abdominal fullness recurred and CT revealed an enlarging tumor and increasing ascites. Capsule endoscopy (CE) and double-balloon enteroscopy (DBE) were performed to further investigate hypoalbuminemia, which revealed white villi, white nodules, white debris, and mucosal edema in the jejunum...
August 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28657157/cyberknife-with-integrated-ct-on-rails-system-description-and-first-clinical-application-for-pancreas-sbrt
#12
Chrysi Papalazarou, Gijsbert J Klop, Maaike T W Milder, Johannes P A Marijnissen, Vikas Gupta, Ben J M Heijmen, Joost J M E Nuyttens, Mischa S Hoogeman
PURPOSE: This paper reports on the integration of a sliding-gantry CT-on-rails with a robotic linear accelerator. METHODS: The system consists of a SOMATOM Definition AS CT scanner (Siemens Healthcare, Forchheim, Germany) and a CyberKnife M6 FIM (Accuray, Inc., Sunnyvale, CA, USA). Additional movement programs were implemented in the robotic treatment table (RoboCouch, Accuray Inc.) to move between CT and treatment position. Acceptance testing was performed on the CT scanner according to AAPM83 guidelines, as well as safety tests for collision avoidance and electromagnetic (EM) compatibility...
June 28, 2017: Medical Physics
https://www.readbyqxmd.com/read/28655067/fatal-ulcerative-enteritis-of-the-small-intestine-in-a-patient-with-ulcerative-colitis-treated-with-vedolizumab
#13
Carmen Monasterio, Annette Schmitt-Gräff, Matthias Pohl, Thomas Truschel, Klaus Warnatz, Wolfgang Kreisel, Robert Thimme, Peter Hasselblatt
Vedolizumab (VDZ) inhibits α4β7 integrins and is used to target intestinal immune responses in patients with inflammatory bowel disease, which is considered to be relatively safe. Here we report on a fatal complication following VDZ administration. A 64-year-old female patient with ulcerative colitis (UC) refractory to tumor necrosis factor inhibitors was treated with VDZ. One week after the second VDZ infusion, she was admitted to hospital with severe diarrhea and systemic inflammatory response syndrome (SIRS)...
June 27, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28653251/suggestion-of-added-value-by-bevacizumab-to-chemotherapy-in-patients-with-unresectable-or-recurrent-small-bowel-cancer
#14
Kotoe Takayoshi, Hitoshi Kusaba, Masato Uenomachi, Kenji Mitsugi, Chinatsu Makiyama, Akitaka Makiyama, Keita Uchino, Tsuyoshi Shirakawa, Yoshihiro Shibata, Yudai Shinohara, Kyoko Inadomi, Kenji Tsuchihashi, Shuji Arita, Hiroshi Ariyama, Taito Esaki, Koichi Akashi, Eishi Baba
PURPOSE: Standard therapy for advanced small bowel adenocarcinoma (SBA) has not yet been established. The present study assessed the efficacy and safety of chemotherapy (CT) in association with molecular targeting approaches for SBA. METHODS: The histories of 33 advanced SBA patients from six different institutions in Japan, who received CT from 2008 to 2016, were retrospectively examined for background, clinical course and outcome. RESULTS: Median patient age was 65 years (range 39-83)...
June 26, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28650564/the-impact-of-extrahepatic-disease-among-patients-undergoing-liver-directed-therapy-for-neuroendocrine-liver-metastasis
#15
Aslam Ejaz, Brad N Reames, Shishir Maithel, George A Poultsides, Todd W Bauer, Ryan C Fields, Matt Weiss, Hugo Pinto Marques, Luca Aldrighetti, Timothy M Pawlik
INTRODUCTION: Management of neuroendocrine liver metastasis (NELM) in the presence of extrahepatic disease (EHD) is controversial. We sought to examine outcomes of patients undergoing liver-directed therapy (resection, ablation, or both) for NELM in the presence of EHD using a large international cohort of patients. METHODS: 612 patients who underwent liver-directed therapy were identified from eight institutions. Postoperative outcomes, as well as and overall (OS) were compared among patients with and without EHD...
June 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28649123/extraovarian-primary-peritoneal-carcinomatosis-a-case-report
#16
Gregory Nicolas, Tony Kfoury, Hassan Fawaz, Mahdi Issa
BACKGROUND Extraovarian primary peritoneal carcinoma (EOPPC) is a rare malignant epithelial tumor with an age-adjusted incidence rate of 6.78 per million, which arises from the peritoneal lining with minimal or no ovarian involvement. EOPPC is a diagnosis of exclusion with the absence of other identifiable primary sites and after surgical assessment and consideration of the histological report to evaluate the extent of ovarian invasion. CASE REPORT A 66-year-old woman complained of mild postprandial epigastric pain...
June 26, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28639576/laparoscopic-versus-open-resection-of-small-bowel-gastrointestinal-stromal-tumors-systematic-review-and-meta-analysis
#17
Ke Chen, Bin Zhang, Yue-Long Liang, Lin Ji, Shun-Jie Xia, Yu Pan, Xue-Yong Zheng, Xian-Fa Wang, Xiu-Jun Cai
BACKGROUND: Laparoscopic resection (LAP) for small bowel gastrointestinal stromal tumors (GISTs) is not as common as for stomach. This study aimed to evaluate the safety and efficacy of LAP for small bowel GISTs with systematic review and meta-analysis. METHODS: The Web of Science, Cochrane Library, Embase, and PubMed databases before December 2016 were comprehensively searched to retrieve comparative trials of LAP and conventional open resection (OPEN) for GISTs of small bowel with a relevance of review object...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28617917/genomic-profiling-of-small-bowel-adenocarcinoma
#18
Alexa B Schrock, Craig E Devoe, Robert McWilliams, James Sun, Thomas Aparicio, Philip J Stephens, Jeffrey S Ross, Richard Wilson, Vincent A Miller, Siraj M Ali, Michael J Overman
Importance: Small-bowel adenocarcinomas (SBAs) are rare cancers with a significantly lower incidence, later stage at diagnosis, and worse overall survival than other intestinal-derived cancers. To date, comprehensive genomic analysis of SBA is lacking. Objective: To perform in-depth genomic characterization of a large series of SBAs and other gastrointestinal tumors to draw comparisons and identify potentially clinically actionable alterations. Design, Setting, and Participants: Prospective analysis was performed of clinical samples from patients with SBA (n = 317), colorectal cancer (n = 6353), and gastric carcinoma (n = 889) collected between August 24, 2012, and February 3, 2016, using hybrid-capture-based genomic profiling, at the request of the individual treating physicians in the course of clinical care for the purpose of making therapy decisions...
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28617885/the-role-of-wireless-capsule-endoscopy-wce-in-the-detection-of-occult-primary-neuroendocrine-tumors
#19
Manuele Furnari, Andrea Buda, Gabriele Delconte, Davide Citterio, Theodor Voiosu, Giovanni Ballardini, Flaminia Cavallaro, Edoardo Savarino, Vincenzo Mazzaferro, Emanuele Meroni
BACKGROUND AND AIMS: Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms with unclear etiology that may show functioning or non-functioning features. Primary tumor localization often requires integrated imaging. The European Neuroendocrine Tumors Society (ENETS) guidelines proposed wireless-capsule endoscopy (WCE) as a possible diagnostic tool for NETs, if intestinal origin is suspected. However, its impact on therapeutic management is debated. We aimed to evaluate the yield of WCE in detecting intestinal primary tumors in patients showing liver NET metastases when first-line investigations are inconclusive...
June 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28609828/congenital-jejunal-diverticular-bleeding-in-a-young-adult
#20
Ji-Yung Lee, Jae-Young Jang, Min-Je Kim, Tae-In Lee, Jung-Wook Kim, Young-Woon Chang
Diverticular bleeding of the small bowel is rare and occurs primarily in adults aged more than 60 years. In younger adults, Meckel's diverticulum, a true diverticulum that congenitally occurs in the distal ileum, is the most common cause of diverticular bleeding of the small bowel. Unlike Meckel's diverticula, other kinds of small bowel diverticula are not congenital and their incidence is related to age. Furthermore, congenital true diverticular bleeding of the jejunum in adults is very rare. We report the case of a 24-year-old man with subepithelial tumor-like lesion accompanied with obscure overt gastrointestinal bleeding (OOGIB)...
June 14, 2017: Clinical Endoscopy
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