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https://www.readbyqxmd.com/read/28929919/evaluating-the-efficacy-of-functional-electrical-stimulation-therapy-assisted-walking-after-chronic-motor-incomplete-spinal-cord-injury-effects-on-bone-biomarkers-and-bone-strength
#1
B Catharine Craven, Lora M Giangregorio, S Mohammad Alavinia, Lindsie A Blencowe, Naaz Desai, Sander L Hitzig, Kei Masani, Milos R Popovic
To determine the efficacy of functional electrical stimulation therapy assisted walking (FES-T) compared to a conventional aerobic and resistance training (CONV) with respect to bone biomarkers and lower extremity bone strength outcomes among adults with chronic motor incomplete spinal cord injury (SCI). Design Parallel group randomized controlled trial ( www.clinicaltrials.gov - NCT0020196819). Site Tertiary academic rehabilitation centre in Canada. Methods Adults with chronic (≥18 months) motor incomplete SCI (C2-T12 AIS C-D) were consented and randomized to FES-T or CONV training for 45 minutes thrice-weekly for 4 months...
September 20, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28914982/production-of-accurate-skeletal-models-of-domestic-animals-using-three-dimensional-scanning-and-printing-technology
#2
Fangzheng Li, Chunying Liu, Xuexiong Song, Yanjun Huan, Shansong Gao, Zhongling Jiang
Access to adequate anatomical specimens can be an important aspect in learning the anatomy of domestic animals. In this study, the authors utilized a structured light scanner and fused deposition modeling (FDM) printer to produce highly accurate animal skeletal models. First, various components of the bovine skeleton, including the femur, the fifth rib, and the sixth cervical (C6) vertebra were used to produce digital models. These were then used to produce 1:1 scale physical models with the FDM printer. The anatomical features of the digital models and three-dimensional (3D) printed models were then compared with those of the original skeletal specimens...
September 15, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28906599/dual-extrusion-3d-printing-of-anatomical-models-for-education
#3
Michelle L Smith, James F X Jones
Two material 3D printing is becoming increasingly popular, inexpensive and accessible. In this paper, freely available printable files and dual extrusion fused deposition modelling were combined to create a number of functional anatomical models. To represent muscle and bone FilaFlex(3D) flexible filament and polylactic acid (PLA) filament were extruded respectively via a single 0.4 mm nozzle using a Big Builder printer. For each filament, cubes (5 mm(3) ) were printed and analyzed for X, Y, and Z accuracy...
September 14, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28901182/effects-of-bone-marrow-derived-msc-transplantation-on-functional-recovery-in-a-rat-model-of-spinal-cord-injury-comparisons-of-transplant-locations-and-cell-concentrations
#4
Jessica J Matyas, Andrew N Stewart, Alison Goldsmith, Zhenhong Nan, Reid L Skeel, Julien Rossignol, Gary L Dunbar
Spinal cord injury (SCI) is a widely disabling condition, constraining those affected by it to wheelchairs and requiring intense daily care and assistance. Cell replacement therapies, targeting regeneration of cells in the injured cord, are currently gaining momentum in the field of SCI research. Previous studies indicate that mesenchymal stem cells (MSCs) can reduce functional deficits through immunomodulation and production of trophic factors in a variety of neurological disorders. The present study assessed the efficacy of transplanted bone marrow-derived MSCs at different concentrations and locations for promoting functional recovery following SCI...
August 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28854256/peripheral-denervation-participates-in-heterotopic-ossification-in-a-spinal-cord-injury-model
#5
Charlotte Debaud, Marjorie Salga, Laurent Begot, Xavier Holy, Malha Chedik, Nicolas de l'Escalopier, Fréderic Torossian, Jean-Pierre Levesque, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdilès, François Genêt
We previously reported the development of a new acquired neurogenic HO (NHO) mouse model, combining spinal cord transection (SCI) and chemical muscle injury. Pathological mechanisms responsible for ectopic osteogenesis after central neurological damage are still to be elucidated. In this study, we first hypothesized that peripheral nervous system (PNS) might convey pathological signals from injured spinal cord to muscles in NHO mouse model. Secondly, we sought to determine whether SCI could lead to intramuscular modifications of BMP2 signaling pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28851622/improved-stem-cell-therapy-of-spinal-cord-injury-using-gdnf-overexpressed-bone-marrow-stem-cells-in-a-rat-model
#6
Mostafa Shahrezaie, Reyhaneh Nassiri Mansour, Bahare Nazari, Hadi Hassannia, Fatemeh Hosseini, Hossein Mahboudi, Mohamad Eftekhary, Mousa Kehtari, Arash Veshkini, Abbas Ahmadi Vasmehjani, Seyed Ehsan Enderami
The use of stem cell base therapy as an effective strategy for the treatment of spinal cord injury (SCI) is very promising. Although some strategy has been made to generate neural-like cells using bone marrow mesenchymal stem cells (BMSCs), the differentiation strategies are still inefficiently. For this purpose, we improved the therapeutic outcome with utilize both of N-neurotrophic factor derived Gelial cells (GDNF) gene and differentiation medium that induce the BMSCs into the neural-like cells. The differentiated GDNF overexpressed BMSCs (BMSCs-GDNF) were injected on the third day of post-SCI...
August 26, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28842819/musculoskeletal-health-in-the-context-of-spinal-cord-injury
#7
REVIEW
Jillian M Clark, David M Findlay
PURPOSE OF REVIEW: This review assembles recent understanding of the profound loss of muscle and bone in spinal cord injury (SCI). It is important to try to understand these changes, and the context in which they occur, because of their impact on the wellbeing of SC-injured individuals, and the urgent need for viable preventative therapies. RECENT FINDINGS: Recent research provides new understanding of the effects of age and systemic factors on the response of bone to loading, of relevance to attempts to provide load therapy for bone in SCI...
August 25, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28804041/cell-therapy-as-a-new-approach-to-the-treatment-of-posttraumatic-syringomyelia
#8
Jesús Vaquero, Rasha Hassan, Cecilia Fernández, Gregorio Rodríguez-Boto, Mercedes Zurita
BACKGROUND: Cell transplantation with autologous bone marrow-derived mesenchymal stromal cells (MSCs) seems to be a therapeutic promise for patients with established spinal cord injury (SCI), achieving improvement in their quality of life, but there is no experience about the application of this type of cell therapy in patients suffering posttraumatic syringomyelia. OBJECTIVE: To study the possible utility of cell therapy with autologous MSCs in posttraumatic syringomyelia...
August 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28803602/short-and-long-term-therapeutic-efficacies-of-intravenous-transplantation-of-bone-marrow-stem-cells-on-cardiac-function-in-rats-with-acute-myocardial-infarction-a-meta-analysis-of-randomized-controlled-trials
#9
Can Jiang, Dong Zheng, Yun-Lu Feng, Jun Guo, Hai-Rui Li, Ai-Dong Zhang
Objective To investigate the short- and long-term therapeutic efficacies of intravenous trans- plantation of bone marrow stem cells (MSCs) in rats with experimental myocardial infarction by meta- analysis. Methods Randomized controlled trials were systematically searched from PubMed, Science Citation Index (SCI), Chinese journal full-text database (CJFD) up to December 2014. While the experimental groups (MSCs groups) were injected MSCs intravenously, the control groups were injected Delubecco's minimum essential medium (DMEM) or phosphate buffered saline (PBS)...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28776131/pure-distraction-injury-of-t1-2-with-quad-fever
#10
Jun-Yeong Seo, Chae-Moon Lim, Young-Hoon Kim, Kee-Yong Ha
INTRODUCTION: We report a pure distraction injury of the upper thoracic spine and uncontrolled hyperthermia without an infectious cause. Quad fever appears in the first several weeks to months after a cervical or upper thoracic SCI and is characterized by an extreme elevation in body core temperature beyond 40 °C without an infectious cause. Discriminating between infectious and noninfectious causes is important, and a thorough clinical assessment is required. MATERIALS AND METHODS: A 52-year-old male visited the emergency room complaining of back pain with complete paralysis [American Spinal Injury Association (ASIA) A] of both lower extremities after a pedestrian-motor vehicle accident...
August 3, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28770686/body-composition-changes-with-testosterone-replacement-therapy-following-spinal-cord-injury-and-aging-a-mini-review
#11
Tom E Nightingale, Pamela Moore, Joshua Harman, Refka Khalil, Ranjodh S Gill, Teodoro Castillo, Robert A Adler, Ashraf S Gorgey
Context Hypogonadism is a male clinical condition in which the body does not produce enough testosterone. Testosterone plays a key role in maintaining body composition, bone mineral density, sexual function, mood, erythropoiesis, cognition and quality of life. Hypogonadism can occur due to several underlying pathologies during aging and in men with physical disabilities, such as spinal cord injury (SCI). This condition is often under diagnosed and as a result, symptoms undertreated. Methods In this mini-review, we propose that testosterone replacement therapy (TRT) may be a viable strategy to improve lean body mass (LBM) and fat mass (FM) in men with SCI...
August 3, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28760352/image-guided-percutaneous-intralesional-administration-of-mesenchymal-stromal-cells-in-subjects-with-chronic-complete-spinal-cord-injury-a-pilot-study
#12
Ticiana Ferreira Larocca, Carolina Thé Macêdo, Bruno Solano de Freitas Souza, Yuri M Andrade-Souza, Cristiane Flora Villarreal, André Costa Matos, Daniela Nascimento Silva, Kátia Nunes da Silva, Clarissa Lima E Moura de Souza, Daniela da Silva Paixão, Milena da Rocha Bezerra, Rodrigo Leal Alves, Milena Botelho Pereira Soares, Ricardo Ribeiro Dos Santos
BACKGROUND AIMS: The potential of cell therapies to improve neurological function in subjects with spinal cord injury (SCI) is currently under investigation. In this context, the choice of cell type, dose, route and administration regimen are key factors. Mesenchymal stromal cells (MSCs) can be easily obtained, expanded and are suitable for autologous transplantation. Here we conducted a pilot study that evaluated safety, feasibility and potential efficacy of intralesional MSCs transplantation performed through image-guided percutaneous injection, in subjects with chronic complete SCI...
July 28, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28733344/effects-of-exercise-on-fitness-and-health-of-adults-with-spinal-cord-injury-a-systematic-review
#13
REVIEW
Jan W van der Scheer, Kathleen A Martin Ginis, David S Ditor, Victoria L Goosey-Tolfrey, Audrey L Hicks, Christopher R West, Dalton L Wolfe
OBJECTIVE: To synthesize and appraise research testing the effects of exercise interventions on fitness, cardiometabolic health, and bone health among adults with spinal cord injury (SCI). METHODS: Electronic databases were searched (1980-2016). Included studies employed exercise interventions for a period ≥2 weeks, involved adults with acute or chronic SCI, and measured fitness (cardiorespiratory fitness, power output, or muscle strength), cardiometabolic health (body composition or cardiovascular risk factors), or bone health outcomes...
July 21, 2017: Neurology
https://www.readbyqxmd.com/read/28702437/treadmill-exercise-with-bone-marrow-stromal-cells-transplantation-potentiates-recovery-of-locomotor-function-after-spinal-cord-injury-in-rats
#14
You-Mi Kim, Tae-Beom Seo, Chang-Ju Kim, Eun-Sang Ji
Transplantation of bone marrow stromal cells (BMSCs) is regarded as a promising candidate for the spinal cord injury (SCI). In the present study, we investigated whether treadmill exercise potentiate the effect of BM-SCs transplantation on the functional recovery in the SCI rats. The spinal cord contusion injury applied at the T9-T10 level using the impactor. Cultured BMSCs were transplanted into the lesion at 1 week after SCI induction. Treadmill exercise was conducted for 6 weeks. Basso-Beattie-Bresnahan (BBB) scale for locomotor function was determined...
June 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28663095/meta-analysis-of-stem-cell-transplantation-for-reflex-hypersensitivity-after-spinal-cord-injury
#15
Xuemei Chen, Bohan Xue, Yuping Li, Chunhua Song, Peijun Jia, Xiuhua Ren, Weidong Zang, Jian Wang
Stem cells have been used in novel therapeutic strategies for spinal cord injury (SCI), but the effect of stem cell transplantation on neuropathic pain after SCI is unclear. The current meta-analysis evaluates the effects of stem cell transplantation on neuropathic pain after SCI. We first conducted online searches of PubMed, Web of Science, China Academic Journals Full-text Database, and Wanfang Data for randomized controlled trials that compared stem cell transplantation and vehicle treatments in rodent models of neuropathic pain after SCI...
June 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/28662973/assessment-of-bone-mineral-density-at-the-distal-femur-and-the-proximal-tibia-by-dual-energy-x-ray-absorptiometry-in-individualswith-spinal-cord-injury-precision-of-protocol-and-relation-to-injury-duration
#16
Stacey Lobos, Anne Cooke, Gillian Simonett, Chester Ho, Steven K Boyd, W Brent Edwards
Spinal cord injury (SCI) is characterized by marked bone loss at the knee, and there is a need for established dual-energy X-ray absorptiometry (DXA) protocols to examine bone mineral density (BMD) at this location to track therapeutic progress and to monitor fracture risk. The purpose of this study was to quantify the precision and reliability of a DXA protocol for BMD assessment at the distal femur and the proximal tibia in individuals with SCI. The protocol was subsequently used to investigate the relationship between BMD and duration of SCI...
June 26, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28624824/effect-of-tnf-%C3%AE-inhibition-on-bone-marrow-derived-mesenchymal-stem-cells-in-neurological-function-recovery-after-spinal-cord-injury-via-the-wnt-signaling-pathway-in-a-rat-model
#17
Ren-Jun Peng, Bing Jiang, Xi-Ping Ding, He Huang, Yi-Wei Liao, Gang Peng, Quan Cheng, Jian Xi
AIM: The present study aimed to examine the effect of tumor necrosis factor-α (TNF-α) inhibition on bone marrow-derived mesenchymal stem cells (BMSCs) in neurological function recovery after spinal cord injury (SCI) via the Wnt signaling pathway in a rat model. METHODS: The rat model of SCI was established using Allen's method. Seventy-two adult male Sprague Dawley (SD) rats were randomly assigned into 4 groups (18 rats in each group): the sham control group, saline control group, BMSCs group (injection with BMSCs at the injured site) and BMSCs + TNF-α group (injection with BMSCs under TNF-α treatment at the injured site)...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28616259/hyperphosphatemia-in-a-patient-with-spinal-cord-injury-who-received-etidronate-for-the-treatment-of-heterotopic-ossification
#18
Sahil Taravati, Ece Cinar, Yesim Akkoc
INTRODUCTION: Heterotopic ossification (HO) is defined as ectopic bone formation around peripheral joints and in soft tissues. HO is a common complication of diseases of the central nervous system, such as spinal cord injury (SCI) and traumatic brain injury. HO is seen in up to 50% of patients with SCI and typically occurs in the first 12 weeks after onset of injury. Although no treatment method is proven to be curative, nonsteroidal anti-inflammatory drugs, irradiation of the involved body part and bisphosphonates are commonly used in the management of HO...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28616021/mri-analysis-and-clinical-significance-of-lower-extremity-muscle-cross-sectional-area-after-spinal-cord-injury
#19
REVIEW
Robert M Lester, Kori Johnson, Refka E Khalil, Rehan Khan, Ashraf S Gorgey
Shortly after spinal cord injury (SCI), the musculoskeletal system undergoes detrimental changes in size and composition, predominantly below the level of injury. The loss of muscle size and strength, along with increased immobility, predisposes persons with SCI to rapid and severe loss in bone mineral density and other health related consequences. Previous studies have highlighted the significance of measuring thigh muscle cross-sectional area, however, measuring the size and composition of muscles of the lower leg may provide insights on how to decrease the risk of various comorbidities...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28607522/agreement-between-fragility-fracture-risk-assessment-algorithms-as-applied-to-adults-with-chronic-spinal-cord-injury
#20
T Cervinka, C L Lynch, L Giangregorio, J D Adachi, A Papaioannou, L Thabane, B C Craven
STUDY DESIGN: Cross-sectional. OBJECTIVES: The objective of the study was to determine and report agreement in fracture risk stratification of adults with spinal cord injury (SCI) using (1) Canadian Association of Radiologists and Osteoporosis Canada (CAROC) and Canadian Fracture Risk Assessment (FRAX) tools with and without areal bone mineral density (aBMD) and (2) SCI-specific fracture thresholds. SETTING: Tertiary rehabilitation center, Ontario, Canada...
June 13, 2017: Spinal Cord
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