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https://www.readbyqxmd.com/read/28433727/superficial-swab-versus-deep-tissue-biopsy-for-the-microbiological-diagnosis-of-local-infection-in-advanced-stage-pressure-ulcers-of-spinal-cord-injured-patients-a-prospective-study
#1
Sara Tedeschi, Luca Negosanti, Rossella Sgarzani, Filippo Trapani, Salvatore Pignanelli, Micaela Battilana, Rita Capirossi, Donatella Brillanti Ventura, Maddalena Giannella, Michele Bartoletti, Fabio Tumietto, Francesco Cristini, Pierluigi Viale
OBJECTIVE: To assess the predictive value of superficial ulcer swab culture to make a microbiological diagnosis of deep wound infections in spinal cord injury (SCI) patients with advanced-stage pressure ulcers (PU). METHODS: From July 2011 to February 2014, we performed a prospective, single-centre study on adult SCI patients undergoing scheduled surgical debridement and reconstruction for advanced-stage PU, at Montecatone Rehabilitation Institute, a 150-bed hospital dedicated to SCI care...
April 19, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28423232/a-psychometric-evaluation-of-the-anatomy-learning-experiences-questionnaire-and-correlations-with-learning-outcomes
#2
Derek L Choi-Lundberg, Anne-Marie M Williams, Craig Zimitat
The Anatomy Learning Experiences Questionnaire (ALEQ) was designed by Smith and Mathias to explore students' perceptions and experiences of learning anatomy. In this study, the psychometric properties of a slightly altered 34-item ALEQ (ALEQ-34) were evaluated, and correlations with learning outcomes investigated, by surveying first- and second-year undergraduate medical students; 181 usable responses were obtained (75% response rate). Psychometric analysis demonstrated overall good reliability (Cronbach's alpha of 0...
April 17, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28408732/glial-cell-line-derived-neurotrophic-factor-transfected-placenta-derived-versus-bone-marrow-derived-mesenchymal-cells-for-treating-spinal-cord-injury
#3
Yao Lu, Hui Gao, Man Zhang, Bing Chen, Huilin Yang
BACKGROUND Placenta-derived mesenchymal stem cells (PMSCs) were isolated from placenta and had differentiation and self-renewal potential. We transfected PMSCs with glial cell line-derived neurotrophic factor (GDNF) and compared their effect for repairing spinal cord injury (SCI) with that of GDNF-transfected bone marrow-derived mesenchymal stem cell (BMSC). MATERIAL AND METHODS The PMSCs were isolated from Sprague-Dawley rat placenta; BMSCs were isolated from Sprague-Dawley rat thigh bone marrow. Primary cultured BMSCs and PMSCs were uniformly spindle-shaped...
April 14, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28392569/multichannel-polymer-scaffold-seeded-with-activated-schwann-cells-and-bone-mesenchymal-stem-cells-improves-axonal-regeneration-and-functional-recovery-after-rat-spinal-cord-injury
#4
Er-Zhu Yang, Guo-Wang Zhang, Jian-Guang Xu, Shuai Chen, Hua Wang, Liang-Liang Cao, Bo Liang, Xiao-Feng Lian
The adult mammalian CNS has a limited capacity to regenerate after traumatic injury. In this study, a combinatorial strategy to promote axonal regeneration and functional recovery after spinal cord injury (SCI) was evaluated in adult rats. The rats were subjected to a complete transection in the thoracic spinal cord, and multichannel scaffolds seeded with activated Schwann cells (ASCs) and/or rat bone marrow-derived mesenchymal stem cells (MSCs) were acutely grafted into the 3-mm-wide transection gap. At 4 weeks post-transplantation and thereafter, the rats receiving scaffolds seeded with ASCs and MSCs exhibited significant recovery of nerve function as shown by the Basso, Beattie and Bresnahan (BBB) score and electrophysiological test results...
April 10, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28365701/suppression-of-microrna-383-enhances-therapeutic-potential-of-human-bone-marrow-derived-mesenchymal-stem-cells-in-treating-spinal-cord-injury-via-gdnf
#5
Guo-Jun Wei, Gang An, Zuo-Wei Shi, Kai-Fu Wang, Ying Guan, Yan-Song Wang, Bo Han, En-Ming Yu, Peng-Fei Li, Da-Ming Dong, Li-Ping Wang, Zhao-Wei Teng, De-Lai Zhao
BACKGROUND/AIMS: Transplantation of bone-marrow-derived mesenchymal stem cells (MSCs) has been used to treat spinal cord injury (SCI) to enhance tissue repair and neural cell regeneration. Glial cell line derived neurotrophic factor (GDNF) is an identified neural growth and survival factor. Here, we examined whether modification of GDNF levels in MSCs may further increase the potential of MSCs in promoting neural cell regeneration and subsequently the therapeutic outcome. METHODS: We examined the mRNA and protein levels of GDNF in human MSCs by RT-qPCR and Western blot, respectively...
March 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28351209/effects-of-multiple-injection-of-bone-marrow-mononuclear-cells-on-spinal-cord-injury-of-rats
#6
Kenji Kanekiyo, Norihiko Nakano, Tamami Homma, Yoshihiro Yamada, Masahiro Tamachi, Yoshihisa Suzuki, Masanori Fukushima, Fukuki Saito, Chizuka Ide
The effects of multiple-injection of bone marrow mononuclear cells (BMNCs) on spinal cord injury (SCI) were compared with those of single-injection in rats. BMNCs separated by density-gradient centrifugation from a bone marrow perfusate were injected 3 times (once weekly) through the cerebrospinal fluid (CSF) via the 4th ventricle, and the locomotor improvement and tissue recovery, including axonal regeneration, were compared with those of single-injection. While the single-injection group showed a steep elevation of the BBB (Basso-Beattie-Bresnahan) score 1 week after transplantation, the multiple-injection group maintained a similar steep elevation for 2 weeks after transplantation, and the BBB scores of the multiple-injection group remained thereafter at a level around 2-3 points higher than those of the single-injection group until the end of the experiment...
March 28, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28338402/testosterone-plus-finasteride-prevents-bone-loss-without-prostate-growth-in-a-rodent-spinal-cord-injury-model
#7
Joshua F Yarrow, Ean G Phillips, Christine F Conover, Taylor E Bassett, Cong Chen, Tyler Teurlings, Andrea Vasconez, Jonathan Alerte, Hannah M Prock, Jessica M Jiron, Micah Flores, J Ignacio Aguirre, Stephen E Borst, Fan Ye
We have reported that testosterone-enanthate (TE) prevents the musculoskeletal decline occurring acutely after spinal cord injury (SCI), but results in a near doubling of prostate mass. Our purpose was to test the hypothesis that administration of TE plus finasteride (FIN, type II 5α-reductase inhibitor) would prevent the chronic musculoskeletal deficits in our rodent severe contusion SCI model, without inducing prostate enlargement. Forty-three 16-week old male Sprague-Dawley rats received: (1) SHAM surgery (T9 laminectomy), (2) severe (250 kdyne) contusion SCI, (3) SCI+TE (7...
March 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28322240/international-spinal-cord-injury-endocrine-and-metabolic-extended-data-set
#8
W A Bauman, J M Wecht, F Biering-Sørensen
OBJECTIVE: The objective of this study was to develop the International Spinal Cord Injury (SCI) Endocrine and Metabolic Extended Data Set (ISCIEMEDS) within the framework of the International SCI Data Sets that would facilitate consistent collection and reporting of endocrine and metabolic findings in the SCI population. SETTING: This study was conducted in an international setting. METHODS: The ISCIEMEDS was developed by a working group...
March 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28290190/disruption-in-bone-marrow-fat-may-attenuate-testosterone-action-on-muscle-size-after-spinal-cord-injury-a-case-report
#9
Ashraf S Gorgey, Pamela D Moore, Rodney C Wade, Ranjodh S Gill, Timothy Lavis, Robert A Adler
BACKGROUND: Mesenchymal stem cells can be differentiated into muscle satellite cells. Testosterone replacement therapy (TRT) promotes the differentiation of satellite cells into muscle cells. CASE REPORT: A 31 year old male with a T4 complete chronic spinal cord injury (SCI) had fixation for a mid-shaft fracture of the left femur. The participant received transdermal testosterone patches (4mg/day) daily for 16 weeks. Skeletal muscle and yellow bone marrow adiposity cross-sectional areas (CSAs) of both thighs were measured using magnetic resonance imaging...
March 13, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28284666/anthropometric-and-biomechanical-characteristics-of-body-segments-in-persons-with-spinal-cord-injury
#10
Y Fang, L R Morse, N Nguyen, N G Tsantes, K L Troy
People with spinal cord injury (SCI) experience bone and muscle loss in their paralyzed limbs that is most rapid and severe in the first 3years after injury. Restoration of mechanical loading through therapeutic physical activity may potentially slow or reverse post-SCI bone loss, however, therapeutic targets cannot be developed without accurate biomechanical models. Obesity is prevalent among SCI population, and it alters body composition and further affects parameters of these models. Here, clinical whole body dual-energy X-ray absorptiometry data from people with acute (n=39) and chronic (n=61) SCI were analyzed to obtain anthropometric parameters including segment masses, center of mass location, and radius of gyration for both obese and non-obese individuals...
April 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28255089/anthropometric-prediction-of-skeletal-muscle-cross-sectional-area-in-persons-with-spinal-cord-injury
#11
Rodney C Wade, Ashraf S Gorgey
Finding an accurate and affordable method to quantify muscle size following spinal cord injury (SCI) could provide benefits clinically and in research settings. The purpose of this study was to validate the use of anthropometric measurements versus magnetic resonance imaging (MRI) to evaluate muscle cross-sectional area (CSA) and develop a field equation to predict muscle CSA specific to the SCI population. Twenty-two men with chronic (>1yr) motor complete SCI participated in the current study. Anthropometric measurements, including mid-thigh circumference and anterior skinfold thickness (SFT), were taken on the right thigh...
March 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28254121/corrigendum-to-evaluation-of-mechanical-strengths-of-three-types-of-mini-implants-in-artificial-bones-kaohsiung-j-med-sci%C3%A2-33-2-2017-96-101
#12
Yu-Chuan Tseng, Ju-Hui Wu, Chun-Chan Ting, Hong-Sen Chen, Chun-Ming Chen
No abstract text is available yet for this article.
March 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28231405/three-dimensional-printing-of-x-ray-computed-tomography-datasets-with-multiple-materials-using-open-source-data-processing
#13
Ian M Sander, Matthew T McGoldrick, My N Helms, Aislinn Betts, Anthony van Avermaete, Elizabeth Owers, Evan Doney, Taimi Liepert, Glen Niebur, Douglas Liepert, W Matthew Leevy
Advances in three-dimensional (3D) printing allow for digital files to be turned into a "printed" physical product. For example, complex anatomical models derived from clinical or pre-clinical X-ray computed tomography (CT) data of patients or research specimens can be constructed using various printable materials. Although 3D printing has the potential to advance learning, many academic programs have been slow to adopt its use in the classroom despite increased availability of the equipment and digital databases already established for educational use...
February 23, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28173736/the-alternative-receptor-for-complement-component-5a-c5ar2-conveys-neuroprotection-in-traumatic-spinal-cord-injury
#14
Patrick Biggins, Faith Brennan, Stephen Taylor, Trent Woodruff, Marc Ruitenberg
This study investigated the role of the secondary receptor for complement activation fragment C5a, C5aR2, in secondary inflammatory pathology following contusive spinal cord injury (SCI) in mice. <i>C5ar2<sup>-/-</sup></i> mice exhibited decreased intraparenchymal TNFα and IL-6 acutely after injury but these reductions did not translate into improved outcomes. We show that loss of C5aR2 leads to increased lesion volumes, reduced myelin sparing and significantly worsened recovery from SCI in <i>C5ar2<sup>-/-</sup></i> animals compared to wild-type (WT) controls...
February 7, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28123490/reduced-inflammatory-cell-recruitment-and-tissue-damage-in-spinal-cord-injury-by-acellular-spinal-cord-scaffold-seeded-with-mesenchymal-stem-cells
#15
Yu-Hai Wang, Jian Chen, Jing Zhou, Feng Nong, Jin-Han Lv, Jia Liu
Therapy using acellular spinal cord (ASC) scaffolds seeded with bone marrow stromal cells (BMSCs) has previously been shown to restore function of the damaged spinal cord and improve functional recovery in a rat model of acute hemisected spinal cord injury (SCI). The aim of the present study was to determine whether BMSCs and ASC scaffolds promote the functional recovery of the damaged spinal cord in a rat SCI model through regulation of apoptosis and immune responses. Whether this strategy regulates secondary inflammation, which is characterized by the infiltration of immune cells and inflammatory mediators to the lesion site, in SCI repair was investigated...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28121340/research-on-the-effect-and-mechanism-of-the-cxcr-4-overexpressing-bmscs-combined-with-sdf-1%C3%AE-for-the-cure-of-acute-sci-in-rats
#16
B-W Sun, H-M Shen, B-C Liu, H-L Fang
OBJECTIVE: To evaluate the effect and mechanism of bone marrow stem cells (BMSCs) modified with CXCR-4 gene combined with stromal derived factor-1α (SDF-1α) in the treatment of acute spinal cord injury (SCI) in rats. MATERIALS AND METHODS: CXCR-4 gene was transfected by a virus. Spinal cord injury rats were randomly divided into four groups: control group, SDF-1α group, CXCR-4/BMSC group and combined group. The motor function was evaluated with Blood Brain Barrier (BBB) score and the RNA expression of CXCR-4 were measured by PCR...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28115072/complications-of-spinal-cord-injury-over-the-first-year-after-discharge-from-inpatient-rehabilitation
#17
Michael D Stillman, Jason Barber, Steve Burns, Steve Williams, Jeanne M Hoffman
OBJECTIVES: To describe the prevalence and cumulative incidence (CI) of secondary complications of spinal cord injury (SCI) in the first year after discharge from inpatient rehabilitation (IR). To evaluate potential associations between risk of complications and socio-demographic and injury-specific factors. DESIGN: Secondary analysis of data collected for a single-site, single-blind, randomized controlled trial comparing telephone follow up to usual care. SETTING: Two inpatient rehabilitation units comprising the Northwest Regional SCI System in Seattle, Washington...
January 20, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28112873/transplantation-of-human-bone-marrow-derived-clonal-mesenchymal-stem-cells-reduces-ffibrotic-sscar-fformation-in-a-rat-spinal-cord-injury-model
#18
Moonhang Kim, Kil Hwan Kim, Sun U Song, Tac Ghee Yi, Seung Hwan Yoon, So Ra Park, Byung Hyune Choi
This study aimed at evaluating the therapeutic effect on tissue repair and scar formation of human bone marrow-derived clonal mesenchymal stem cells (hcMSCs) homogeneously isolated by using a subfractionation culturing method, in comparison with the non-clonal MSCs (hMSCs), in a rat spinal cord injury (SCI) model. The SCI was made using a vascular clip at the T9 level. Cells were transplanted into the lesion site 3 days after injury. A functional test was performed over 4 weeks employing a BBB score. Rats were killed for histological analysis at 3 days, 1 week and 4 weeks after injury...
January 23, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28104245/assessing-kinematics-and-kinetics-of-functional-electrical-stimulation-rowing
#19
Adina E Draghici, Glen Picard, J Andrew Taylor, Sandra J Shefelbine
Hybrid functional electrical stimulation (FES) rowing has positive effects on cardiovascular fitness, producing significantly greater aerobic power than either upper body or FES exercise alone. However, there is minimal information on the kinematics, kinetics, and mechanical efficiency of FES-rowing in the spinal cord injured (SCI) population. This study examined the biomechanics of FES-rowing to determine how motions, forces, and aerobic demand change with increasing intensity. Six individuals with SCI and six able-bodied subjects performed a progressive aerobic capacity rowing test...
February 28, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28099928/the-sdf-1-cxcr4-axis-promotes-recovery-after-spinal-cord-injury-by-mediating-bone-marrow-derived-from-mesenchymal-stem-cells
#20
Guo-Dong Wang, Yi-Xun Liu, Xiao Wang, Yong-Le Zhang, Ya-Dong Zhang, Feng Xue
This study aims to explore the role of the SDF-1/CXCR4 axis in mediating BMSCs and SCI recovery. BMSCs were collected and SCI rat models were established. Wistar rats were assigned into the blank control, sham, SCI, SCI + BMSCs, SCI + BMSCs + SDF-1, SCI + BMSCs + AMD3100 (an inhibitor of SDF-1/CXCR4 axis) and SCI + BMSCs + SDF-1 + AMD3100 groups. Hind limb motor function was measured 7, 14, 21 and 28 days after operation. qRT-PCR, western blotting and ELISA was performed to determine the expressions of SDF-1, CXCR4, NGF, BDNF, GFAP and GAP-43, TNF-α, IL-1β, L-6 and IFN-γ...
February 14, 2017: Oncotarget
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