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https://www.readbyqxmd.com/read/29790404/clinical-and-neurophysiological-changes-after-targeted-intrathecal-injections-of-bone-marrow-stem-cells-in-a-c3-tetraplegic-subject
#1
Andrea Jimena Santamaria, Francisco D Benavides, Darcy L DiFede, Aisha Khan, Marietsy V Pujol, W Dalton Dietrich, Antonio Marttos, Barth A Green, Joshua M Hare, James Guest
High-level quadriplegia is a devastating condition with limited treatment options. Bone marrow derived stem cells (BMSCs) are reported to have immunomodulatory and neurotrophic effects in spinal cord injury (SCI). We report a subject with complete C2 SCI who received 3 anatomically targeted intrathecal infusions of BMSCs under a single-patient expanded access IND. She underwent intensive physical therapy and was followed for over 2 years. At end-point, her AIS grade improved from A to B and she recovered focal pressure touch sensation over several body areas...
May 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29776736/trabecular-bone-score-at-the-distal-femur-and-proximal-tibia-in-individuals-with-spinal-cord-injury
#2
Stacey Lobos, Anne Cooke, Gillian Simonett, Chester Ho, Steven K Boyd, W Brent Edwards
Rapid declines in bone mineral density (BMD) at the knee after spinal cord injury (SCI) are associated with an increased risk of fracture. Evaluation of bone quality using the trabecular bone score (TBS) may provide a complimentary measure to BMD assessment to examine bone health and fracture risk after SCI. The purpose of this study was to assess bone mineral density (BMD) and trabecular bone score (TBS) at the knee in individuals with and without SCI. Nine individuals with complete SCI (mean time since SCI 2...
April 24, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29763918/comprehensive-effects-of-suppression-of-microrna-383-in-human-bone-marrow-derived-mesenchymal-stem-cells-on-treating-spinal-cord-injury
#3
Guo-Jun Wei, Ke-Wen Zheng, Gang An, Zuo-Wei Shi, Kai-Fu Wang, Ying Guan, Yan-Song Wang, Peng-Fei Li, Da-Ming Dong
BACKGROUND/AIMS: Transplantation of bone-marrow-derived mesenchymal stem cells (MSCs) promotes neural cell regeneration after spinal cord injury (SCI). Recently, we showed that suppression of microRNA-383 (miR-383) in MSCs increased the protein levels of glial cell line derived neurotrophic factor (GDNF), resulting in improved therapeutic effects on SCI. However, the overall effects of miR-383 suppression in MSCs on SCI therapy were not determined yet. Here, we addressed this question...
May 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29752089/hucmsc-derived-exosomes-promote-functional-recovery-in-spinal-cord-injury-mice-via-attenuating-inflammation
#4
Guodong Sun, Guangqiang Li, Dehai Li, Wanjun Huang, Renwen Zhang, Hua Zhang, Yuanyuan Duan, Baocheng Wang
The exploration of effective spinal cord injury (SCI) healing still remain a great challenge due to the high morbidity, complex pathology and unclear targets. Human umbilical cord mesenchymal stem cells (hucMSC) play an important role in tissue regeneration. However, transplanting stem cells has a potential risk of teratogenicity. Recent studies have suggested that exosomes secreted by stem cells may contribute to tissue injury repair. We hypothesized that the application of hucMSC derived exosomes may be a potential way for SCI treatment...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29729005/can-the-positive-association-of-osteocalcin-with-testosterone-be-unmasked-when-the-preeminent-hypothalamic-pituitary-regulation-of-testosterone-production-is-impaired-the-model-of-spinal-cord-injury
#5
A Barbonetti, S D'Andrea, J Samavat, A Martorella, G Felzani, S Francavilla, M Luconi, F Francavilla
PURPOSE: Osteocalcin (OCN), released from the bone matrix during the resorption phase, in its undercarboxylated form, stimulates testosterone (T) biosynthesis in mouse and a loss-of-function mutation of its receptor was associated with hypergonadotropic hypogonadism in humans. Nevertheless, when population-based studies have explored the OCN-T association, conflicting results have been reported. Hypothesizing that the evidence of a positive association between OCN and T could have been hindered by the preeminent role of a well-functioning hypothalamus-pituitary axis in promoting T biosynthesis, we explored this association in men with chronic spinal cord injury (SCI), exhibiting high prevalence of non-hypergonadotropic androgen deficiency...
May 4, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29676669/sequential-neurological-improvements-after-conservative-treatment-in-patients-with-complete-motor-paralysis-caused-by-cervical-spinal-cord-injury-without-bone-and-disc-injury
#6
Eiji Mori, Takayoshi Ueta, Takeshi Maeda, Ryousuke Ideta, Itaru Yugué, Osamu Kawano, Keiichiro Shiba
OBJECTIVE This study investigated neurological improvements after conservative treatment in patients with complete motor paralysis caused by acute cervical spinal cord injury (SCI) without bone and disc injury. METHODS This study was retrospective. The authors evaluated neurological outcomes after conservative treatment of 62 patients with complete motor paralysis caused by cervical SCI without bone and disc injury within 72 hours after trauma. The sequential changes in their American Spinal Injury Association Impairment Scale (AIS) grades were reviewed at follow-up 24-72 hours, 1 week, and 1, 3, and 6 months after treatment...
April 20, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29614703/potential-risk-of-clonally-expanded-amnion-mesenchymal-stem-cell-transplants-in-contused-spinal-cords
#7
Sankar Venkatachalam, Sridharan Neelamegan, Tetsuhito Okuda, Akiva Marcus, Dale Woodbury, Martin Grumet
OBJECTIVE: Mesenchymal stem/stromal cells (MSC) promote recovery after spinal cord injury (SCI) using adult bone marrow MSC (BM-MSC). Newborn tissues are a convenient source of MSC that does not involve an invasive procedure for cell collection. In this study the authors tested the effects of rat amnion MSC clone (rAM-MSC) in SCI. METHODS: We tested intra-parenchymal injection of a GFP+ rat rAM-MSC clone derived from E18.5 rats in rat SCI and measured behavioral recovery (BBB scores), histology and X-ray opacity...
March 25, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29603656/guiding-low-spatial-ability-individuals-through-visual-cueing-the-dual-importance-of-where-and-when-to-look
#8
Victoria A Roach, Graham M Fraser, James H Kryklywy, Derek G V Mitchell, Timothy D Wilson
Research suggests that spatial ability may predict success in complex disciplines including anatomy, where mastery requires a firm understanding of the intricate relationships occurring along the course of veins, arteries, and nerves, as they traverse through and around bones, muscles, and organs. Debate exists on the malleability of spatial ability, and some suggest that spatial ability can be enhanced through training. It is hypothesized that spatial ability can be trained in low-performing individuals through visual guidance...
March 30, 2018: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29581745/rat-vibrissa-dermal-papilla-cells-promote-healing-of-spinal-cord-injury-following-transplantation
#9
Meiying Li, Xianglin Mei, Shuang Lv, Zechuan Zhang, Jinying Xu, Dongjie Sun, Jiayi Xu, Xia He, Guangfan Chi, Yulin Li
Bone marrow mesenchymal stem cell (BMSC) transplantation is effective for repairing spinal cord injuries (SCIs); however, there are limitations of clinical BMSC applications. Previously, we reported that dermal papilla cells (DPCs) secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor more actively than BMSCs. To analyze the therapeutic function of DPCs in SCI, primary DPCs and BMSCs were cultured from the same green fluorescence protein-transgenic rat. The cells were suspended in rat-tail collagen I and transplanted separately into completely transected spinal cord lesion sites...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29579075/effects-of-pharmacologic-sclerostin-inhibition-or-testosterone-administration-on-soleus-muscle-atrophy-in-rodents-after-spinal-cord-injury
#10
Ean G Phillips, Luke A Beggs, Fan Ye, Christine F Conover, Darren T Beck, Dana M Otzel, Payal Ghosh, Anna C F Bassit, Stephen E Borst, Joshua F Yarrow
Sclerostin is a circulating osteocyte-derived glycoprotein that negatively regulates Wnt-signaling after binding the LRP5/LRP6 co-receptors. Pharmacologic sclerostin inhibition produces bone anabolic effects after spinal cord injury (SCI), however, the effects of sclerostin-antibody (Scl-Ab) on muscle morphology remain unknown. In comparison, androgen administration produces bone antiresorptive effects after SCI and some, but not all, studies have reported that testosterone treatment ameliorates skeletal muscle atrophy in this context...
2018: PloS One
https://www.readbyqxmd.com/read/29567290/effects-of-curcumin-on-bone-loss-and-biochemical-markers-of-bone-turnover-in-patients-with-spinal-cord-injury
#11
Masoud Hatefi, Mohammad Reza Hafezi Ahmadi, Asghar Rahmani, Masoud Moghadas Dastjerdi, Khairollah Asadollahi
BACKGROUND: Osteoporosis is one of the most common problems of patients with spinal cord injuries (SCIs). The current study aimed to evaluate the antiosteoporotic effects of curcumin on densitometry parameters and biomarkers of bone turnovers among patients with SCI. MATERIALS AND METHODS: The current controlled clinical trial was conducted among 100 patients with SCI referred to an outpatient clinic of rehabilitation in Ilam City, Iran, in 2013-2015. The intervention group received 110/mg/kg/day curcumin for 6 months and the control group received placebo...
June 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29564848/validation-of-anthropometric-muscle-cross-sectional-area-equation-after-spinal-cord-injury
#12
Rodney C Wade, Robert M Lester, Ashraf S Gorgey
The purposes of this study were to cross-validate a previously derived anthropometric estimation equation specific to the spinal cord injury population and determine the ratios of absolute skeletal muscle cross-sectional area (CSA) for the quadriceps, hamstrings, and adductor muscle groups based on magnetic resonance imaging. The validation cohort consisted of eleven men with chronic (>1 yr. post injury) spinal cord injury (SCI). Ten individuals were classified as AIS A or B and one participant was classified as an AIS C...
May 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29543759/localized-intrathecal-delivery-of-mesenchymal-stromal-cells-conditioned-medium-improves-functional-recovery-in-a-rat-model-of-spinal-cord-injury
#13
Dasa Cizkova, Veronika Cubinkova, Tomas Smolek, Adriana-Natalia Murgoci, Jan Danko, Katarina Vdoviakova, Filip Humenik, Milan Cizek, Jusal Quanico, Isabelle Fournier, Michel Salzet
It was recently shown that the conditioned medium (CM) of mesenchymal stem cells can enhance viability of neural and glial cell populations. In the present study, we have investigated a cell-free approach via CM from rat bone marrow stromal cells (MScCM) applied intrathecally (IT) for spinal cord injury (SCI) recovery in adult rats. Functional in vitro test on dorsal root ganglion (DRG) primary cultures confirmed biological properties of collected MScCM for production of neurosphere-like structures and axon outgrowth...
March 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29506530/the-effects-of-gait-training-using-powered-lower-limb-exoskeleton-robot-on-individuals-with-complete-spinal-cord-injury
#14
Cheng-Hua Wu, Hui-Fen Mao, Jwu-Sheng Hu, Ting-Yun Wang, Yi-Jeng Tsai, Wei-Li Hsu
BACKGROUND: Powered exoskeleton can improve the mobility for people with movement deficits by providing mechanical support and facilitate the gait training. This pilot study evaluated the effect of gait training using a newly developed powered lower limb exoskeleton robot for individuals with complete spinal cord injury (SCI). METHODS: Two participants with a complete SCI were recruited for this clinical study. The powered exoskeleton gait training was 8 weeks, 1 h per session, and 2 sessions per week...
March 5, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29497572/engraftment-neuroglial-transdifferentiation-and-behavioral-recovery-after-complete-spinal-cord-transection-in-rats
#15
Luzzi Sabino, Crovace Alberto Maria, Lacitignola Luca, Valentini Valerio, Francioso Edda, Rossi Giacomo, Invernici Gloria, Galzio Renato Juan, Crovace Antonio
Background: Proof of the efficacy and safety of a xenogeneic mesenchymal stem cell (MSCs) transplant for spinal cord injury (SCI) may theoretically widen the spectrum of possible grafts for neuroregeneration. Methods: Twenty rats were submitted to complete spinal cord transection. Ovine bone marrow MSCs, retrovirally transfected with red fluorescent protein and not previously induced for neuroglial differentiation, were applied in 10 study rats (MSCG). Fibrin glue was injected in 10 control rats (FGG)...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29462059/effects-of-ultra-early-hyperbaric-oxygen-therapy-on-femoral-calcitonin-gene-related-peptide-and-bone-metabolism-of-rats-with-complete-spinal-transection
#16
Min Liu, Huan Chen, Min Tong, Jinping Zhou, Xiyu Wu
STUDY DESIGN: Seventy-five Sprague-Dawley (SD)rats were randomly divided into sham, complete spinal cord transection (CSCT)and hyperbaric oxygen (HBO) groups. Among them, rats in HBO group were further divided into 3 h group (HBO1) and 12 h group (HBO2). OBJECTIVE: To study the effects of ultra-early HBO therapy on femoral calcitonin gene-related peptide (CGRP) and bone metabolism of rats with CSCT. SUMMARY OF BACKGROUND DATA: Complete SCI is still an unresolved problem in clinical practice...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29458076/bone-marrow-mesenchymal-stem-cells-bmscs-improved-functional-recovery-of-spinal-cord-injury-partly-by-promoting-axonal-regeneration
#17
REVIEW
Liya Lin, Hefeng Lin, Shi Bai, Lianshun Zheng, Xiaoming Zhang
Spinal cord injury (SCI) disrupts the spinal cord and results in the loss of sensory and motor function below the lesion site. The treatment of SCI became a challenge because the injured neurons fail to axon regenerate and repair after injury. Promoting axonal regeneration plays a key role in the treatment strategies for SCI. It would meet the goal of reconstruction the injured spinal cord and improving the functional recovery. Bone marrow mesenchymal stem cells (BMSCs) are attractive therapeutic potential cell sources for SCI, and it could rebuild the injured spinal cord through neuroprotection, neural regeneration and remyelinating...
May 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29453346/anti-inflammatory-effect-of-tauroursodeoxycholic-acid-in-raw-264-7-macrophages-bone-marrow-derived-macrophages-bv2-microglial-cells-and-spinal-cord-injury
#18
Seong Jun Kim, Wan-Kyu Ko, Min-Jae Jo, Yoshie Arai, Hyemin Choi, Hemant Kumar, In-Bo Han, Seil Sohn
This study aimed to investigate the anti-inflammatory effects of tauroursodeoxycholic acid (TUDCA) after spinal cord injury (SCI) in rats. We induced an inflammatory process in RAW 264.7 macrophages, BV2 microglial cells, and bone marrow-derived macrophages (BMM) using lipopolysaccharide (LPS). The anti-inflammatory effects of TUDCA on LPS-stimulated RAW 264.7 macrophages, BV2 microglial cells, and BMMs were analyzed using nitric oxide (NO) assays, quantitative real-time polymerase chain reactions (qRT-PCR), and enzyme-linked immunosorbent assays (ELISA)...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29424661/preventive-care-among-primary-care-patients-living-with-spinal-cord-injury
#19
Aisha Lofters, Maha Chaudhry, Morgan Slater, Andree Schuler, James Milligan, Joseph Lee, Sara J T Guilcher
OBJECTIVE: Context/Objective: Family physicians may lack the knowledge or resources to adequately support patients with spinal cord injury (SCI). Our objectives were to determine patterns of preventive care for patients with SCI in a primary care setting (i.e. cancer screening, influenza vaccinations, general physicals, bone mineral density tests), and determine physicians' level of comfort with providing primary care to patients with SCI. DESIGN: i) Retrospective chart review, ii) Survey of physicians in the family practice...
February 9, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29402167/differential-adaptations-of-the-musculoskeletal-system-after-spinal-cord-contusion-and-transection-in-rats
#20
Ching-Yi Lin, Charlie Androjna, Richard Rozic, Bichtram Nguyen, Brett Parsons, Ronald J Midura, Yu-Shang Lee
Spinal cord injury (SCI) causes impaired neuronal function with associated deficits in the musculoskeletal system, which can lead to permanent disability. Here, the impact of SCI on in vivo musculoskeletal adaptation was determined by studying deficits in locomotor function and analyzing changes that occur in the muscle and bone compartments within the rat hindlimb after contusion or transection SCI. Analyses of locomotor patterns, as assessed via the Basso, Beattie, and Bresnahan (BBB) rating scale, revealed that transection animals showed significant deficits, while the contusion group had moderate deficits, compared with naïve groups...
April 5, 2018: Journal of Neurotrauma
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