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https://www.readbyqxmd.com/read/27905554/increased-plasma-vegf-levels-following-ischemic-preconditioning-are-associated-with-downregulation-of-mirna-762-and-mir-3072-5p
#1
Koji Ueno, Makoto Samura, Tamami Nakamura, Yuya Tanaka, Yuriko Takeuchi, Daichi Kawamura, Masaya Takahashi, Tohru Hosoyama, Noriyasu Morikage, Kimikazu Hamano
Ischemic preconditioning (IPC) has protective effects against ischemia-perfusion injury of organs. In the present study, we investigated the associated mechanisms after performing remote IPC (rIPC) of lower limbs by clamping abdominal aorta in mice. Subsequent experiments showed decreased damage and paralysis of lower limbs following spinal cord injury (SCI). Concomitantly, plasma vascular endothelial growth factor (VEGF) levels were increased 24 h after rIPC compared with those in sham-operated animals. In subsequent microRNA analyses, thirteen microRNAs were downregulated in exosomes 24 h after rIPC...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27885959/bone-marrow-stromal-cell-sheets-may-promote-axonal-regeneration-and-functional-recovery-with-suppression-of-glial-scar-formation-after-spinal-cord-transection-injury-in-rats
#2
Akinori Okuda, Noriko Horii-Hayashi, Takayo Sasagawa, Takamasa Shimizu, Hideki Shigematsu, Eiichiro Iwata, Yasuhiko Morimoto, Keisuke Masuda, Munehisa Koizumi, Manabu Akahane, Mayumi Nishi, Yasuhito Tanaka
OBJECTIVE Transplantation of bone marrow stromal cells (BMSCs) is a theoretical potential as a therapeutic strategy in the treatment of spinal cord injury (SCI). Although a scaffold is sometimes used for retaining transplanted cells in damaged tissue, it is also known to induce redundant immunoreactions during the degradation processes. In this study, the authors prepared cell sheets made of BMSCs, which are transplantable without a scaffold, and investigated their effects on axonal regeneration, glial scar formation, and functional recovery in a completely transected SCI model in rats...
November 25, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27865878/bone-marrow-mesenchymal-stem-cells-decrease-chop-expression-and-neuronal-apoptosis-after-spinal-cord-injury
#3
Chuanlong Gu, Heyangzi Li, Chao Wang, Xinghui Song, Yuemin Ding, Mingzhi Zheng, Wei Liu, Yingying Chen, Xiaoming Zhang, Linlin Wang
Spinal cord injury (SCI) leads to irreversible neuronal loss and ultimately leads to paralysis. Bone marrow derived mesenchymal stem cells (BMSCs) have been demonstrated to be an effective approach to treat SCI. The present study was designed to investigate the role of BMSCs in rats with spinal cord injury and in oxygen-glucose deprivation (OGD) treated motor neurons. The results demonstrated that BMSCs could improve locomotor function and decrease expression of pro-apoptotic transcription factor C/EBP homologous protein (CHOP) and apoptosis after SCI...
November 16, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27857906/current-concept-of-stem-cell-therapy-for-spinal-cord-injury-a-review
#4
REVIEW
Sun Kyu Oh, Sang Ryong Jeon
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, surgery, and rehabilitation therapy for SCI have been performed, but there were no definite treatment option to improve neurological function of patients with chronic SCI. Therefore, new treatment trials with stem cells have been studied to regenerate injured spinal cord. Among various types of stem cells, bone marrow derived mesenchymal stem cells is highly expected as candidates for the stem cell therapy...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27857727/cell-transplantation-for-the-treatment-of-spinal-cord-injury-bone-marrow-stromal-cells-and-choroid-plexus-epithelial-cells
#5
REVIEW
Chizuka Ide, Norihiko Nakano, Kenji Kanekiyo
Transplantation of bone marrow stromal cells (BMSCs) enhanced the outgrowth of regenerating axons and promoted locomotor improvements of rats with spinal cord injury (SCI). BMSCs did not survive long-term, disappearing from the spinal cord within 2-3 weeks after transplantation. Astrocyte-devoid areas, in which no astrocytes or oligodendrocytes were found, formed at the epicenter of the lesion. It was remarkable that numerous regenerating axons extended through such astrocyte-devoid areas. Regenerating axons were associated with Schwann cells embedded in extracellular matrices...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27764190/substance-p-promotes-the-proliferation-but-inhibits-differentiation-and-mineralization-of-osteoblasts-from-rats-with-spinal-cord-injury-via-rankl-opg-system
#6
Hai-Juan Liu, Hua Yan, Jun Yan, Hao Li, Liang Chen, Li-Ren Han, Xiao-Fei Yang
Spinal cord injury (SCI) causes a significant amount of bone loss, which results in osteoporosis (OP). The neuropeptide substance P (SP) and SP receptors may play important roles in the pathogenesis of OP after SCI. To identify the roles of SP in the bone marrow mesenchymal stem cell derived osteoblasts (BMSC-OB) in SCI rats, we investigated the expression of neurokinin-1 receptors (NK1R) in BMSC-OB and the effects of SP on bone formation by development of BMSC-OB cultures. Sixty young male Sprague-Dawley rats were randomized into two groups: SHAM and SCI...
2016: PloS One
https://www.readbyqxmd.com/read/27734100/meagre-effects-of-disuse-on-the-human-fibula-are-not-explained-by-bone-size-or-geometry
#7
A Ireland, R F Capozza, G R Cointry, L Nocciolino, J L Ferretti, J Rittweger
: Fibula response to disuse is unknown; we assessed fibula bone in spinal cord injury (SCI) patients and able-bodied counterparts. Group differences were smaller than in the neighbouring tibia which could not be explained by bone geometry. Differential adaptation of the shank bones may indicate previously unknown mechanoadaptive behaviours of bone. INTRODUCTION: The fibula supports only a small and highly variable proportion of shank compressive load (-8 to +19 %), and little is known about other kinds of stresses...
October 12, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27733220/short-and-long-term-therapeutic-efficacies-of-intravenous-transplantation-of-bone-marrow-stem-cells-on-cardiac-function-in-rats-with-acute-myocardial-infarction-a-meta-analysis-of-randomized-controlled-trials-%C3%A2
#8
Can Jiang, Dong Zheng, Yun-Lu Feng, Jun Guo, Hai-Rui Li, Ai-Dong Zhang
<strong>Objective</strong> To investigate the short- and long-term therapeutic efficacies of intravenous trans- plantation of bone marrow stem cells (MSCs) in rats with experimental myocardial infarction by meta- analysis. <strong>Methods</strong> Randomized controlled trials were systematically searched from PubMed, Science Citation Index (SCI), Chinese journal full-text database (CJFD) up to December 2014. While the experimental groups (MSCs groups) were injected MSCs intravenously, the control groups were injected Delubecco's minimum essential medium (DMEM) or phosphate buffered saline (PBS)...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/27665985/prenatal-alcohol-exposure-reduces-mandibular-calcium-and-phosphorus-concentrations-in-newborn-rats
#9
Isabel C S Carvalho, Carolina da S M Martinelli, Noala V M Milhan, Adriana M P da S Marchini, Tamires P Dutra, Daniela M de Souza, Rosilene F da Rocha
Previous studies suggest that prenatal alcohol exposure affects fetal bone development, including bone quality. This study evaluated the chemical composition of mandibles from newborn rats after maternal 20% alcohol consumption before and throughout gestation. Nine rats were initially distributed into three groups: an Alcohol group, Pair-fed group, and Control group. The groups were fed prespecified diets for 8 weeks before and the 3 weeks during pregnancy. At age 5 days, eight newborns from each group were euthanized (total, n = 24)...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27665982/effect-of-low-intensity-pulsed-ultrasound-lipus-on-mandibular-condyle-growth-in-rats-analyzed-with-micro-ct
#10
Kyozo Sasaki, Mitsuru Motoyoshi, Eri Horinuki, Yoshinori Arai, Noriyoshi Shimizu
This study examined the effects of a bite-jumping appliance combined with low-intensity pulsed ultrasound (LIPUS) stimulation on the mandibular condyle of growing rats using micro CT (mCT) and histological examinations. Twelve Wistar rats were divided into three groups of four individuals each: Group 1 was an untreated control group, Group 2 received bite-jumping appliances, and Group 3 received bite-jumping appliances and LIPUS stimulation (15 min/day, 2 weeks) to the temporomandibular region. We measured the length and three-dimensional bone volume of each rat's mandibular condyle using mCT...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27665970/high-dose-irradiation-of-bone-chips-preserves-the-in-vitro-activity-of-bone-conditioned-medium
#11
Kosaku Sawada, Richard J Miron, Dominic Leiser, Jordi Caballé-Serrano, Dieter D Bosshardt, Benoit Schaller, Daniel Buser, Reinhard Gruber
Extracorporeal irradiation sterilizes resected tumor bone used as autografts in reconstruction surgery. Therapeutic irradiation is a standard technique in head and neck cancer therapy that aims to preserve organ function. Bone irradiation has a complex, mostly inhibitory, effect on remodeling and regeneration, although the underlying mechanisms are still not fully understood. It remains unclear if extracorporeal irradiation affects the paracrine-like activity of the corresponding autografts. We recently reported that bone-conditioned medium from autogenous bone chips contains a number of factors that might affect cell activity...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27645263/vitamin-d-and-spinal-cord-injury-should-we-care
#12
REVIEW
J Lamarche, G Mailhot
STUDY DESIGN: Narrative review. OBJECTIVES: This review provides an overview of the etiological factors and consequences of vitamin D insufficiency in relation to spinal cord injury (SCI) as well as important considerations for vitamin D supplementation. SETTING: Montreal, Canada. METHODS: Literature search. RESULTS: Vitamin D insufficiency is common in SCI individuals owing to the presence of many contributing factors including limited sun exposure and intake, use of medication and endocrine perturbations...
September 20, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27618974/severe-spasticity-in-lower-extremities-is-associated-with-reduced-adiposity-and-lower-fasting-plasma-glucose-level-in-persons-with-spinal-cord-injury
#13
I-Y Jung, H-R Kim, S M Chun, J-H Leigh, H-I Shin
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To investigate the effects of severe lower extremity spasticity on anthropometric dimensions, body composition and metabolic profiles in persons with chronic motor complete spinal cord injury (SCI). SETTING: Outpatient clinic. METHODS: Fifty-five of the 61 participants were divided into two groups (no or mild spasticity group, 28; severe spasticity group, 27) based on the assessment of the extensor muscle spasticity according to the modified Ashworth scale...
September 13, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27591786/treatment-with-hydrogen-sulfide-attenuates-sublesional-skeletal-deterioration-following-motor-complete-spinal-cord-injury-in-rats
#14
X Yang, D Hao, H Zhang, B Liu, M Yang, B He
: Treatment with hydrogen sulfide mitigates spinal cord injury-induced sublesional bone loss, possibly through abating oxidative stress, suppressing MMP activity, and activating Wnt/β-catenin signaling. INTRODUCTION: Spinal cord injury (SCI)-induced sublesional bone loss represents the most severe osteoporosis and is resistant to available treatments to data. The present study was undertaken to explore the therapeutic potential of hydrogen sulfide (H2S) against osteoporosis in a rodent model of motor complete SCI...
September 3, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27586052/intravenous-infusion-of-mesenchymal-stem-cells-promotes-functional-recovery-in-a-model-of-chronic-spinal-cord-injury
#15
Tomonori Morita, Masanori Sasaki, Yuko Kataoka-Sasaki, Masahito Nakazaki, Hiroshi Nagahama, Shinichi Oka, Tsutomu Oshigiri, Tsuneo Takebayashi, Toshihiko Yamashita, Jeffery D Kocsis, Osamu Honmou
Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow improves behavioral function in rat models of spinal cord injury (SCI). However, most studies have focused on the acute or subacute phase of SCI. In the present study, MSCs derived from bone marrow of rats were intravenously infused 10weeks after the induction of a severe contusive SCI. Open field locomotor function was assessed weekly until 20weeks post-SCI. Motor recovery was greater in the MSC-treated group with rapid improvement beginning in earlier post-infusion times than in the vehicle-treated group...
October 29, 2016: Neuroscience
https://www.readbyqxmd.com/read/27563878/anti-inflammatory-mechanism-of-neural-stem-cell-transplantation-in-spinal-cord-injury
#16
Zhijian Cheng, Wen Zhu, Kai Cao, Fei Wu, Jin Li, Guoyu Wang, Haopen Li, Ming Lu, Yi Ren, Xijing He
Neural stem cell (NSC) transplantation has been proposed to promote functional recovery after spinal cord injury. However, a detailed understanding of the mechanisms of how NSCs exert their therapeutic plasticity is lacking. We transplanted mouse NSCs into the injured spinal cord seven days after SCI, and the Basso Mouse Scale (BMS) score was performed to assess locomotor function. The anti-inflammatory effects of NSC transplantation was analyzed by immunofluorescence staining of neutrophil and macrophages and the detection of mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-12 (IL-12)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27523920/it-takes-nerve-to-fight-back-the-significance-of-neural-innervation-of-the-bone-marrow-and-spleen-for-immune-function
#17
Won-Cheol Jung, Jean-Pierre Levesque, Marc J Ruitenberg
Inflammation is a natural part of wound healing but it can also cause secondary (bystander) damage and/or negatively interfere with endogenous repair mechanisms if non-resolving. Regulation of inflammation is traditionally looked at from the perspective of danger signals, cytokines and chemokines, and their respective receptors. A neuronal contribution to the regulation of inflammation is, however, increasingly appreciated, and this has important implications for the bodily response under conditions where the nervous system itself may be damaged...
August 11, 2016: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27510317/transplantation-of-human-skin-derived-mesenchymal-stromal-cells-improves-locomotor-recovery-after-spinal-cord-injury-in-rats
#18
Fernanda Rosene Melo, Raul Bardini Bressan, Stefânia Forner, Alessandra Cadete Martini, Michele Rode, Priscilla Barros Delben, Giles Alexander Rae, Claudia Pinto Figueiredo, Andrea Gonçalves Trentin
Spinal cord injury (SCI) is a devastating neurologic disorder with significant impacts on quality of life, life expectancy, and economic burden. Although there are no fully restorative treatments yet available, several animal and small-scale clinical studies have highlighted the therapeutic potential of cellular interventions for SCI. Mesenchymal stem cells (MSCs)-which are conventionally isolated from the bone marrow-recently emerged as promising candidates for treating SCI and have been shown to provide trophic support, ameliorate inflammatory responses, and reduce cell death following the mechanical trauma...
August 10, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27503121/temporal-and-spatial-evolution-of-raised-intraspinal-pressure-after-traumatic-spinal-cord-injury
#19
Zin Z Khaing, Lindsay N Cates, Amanda E Fischedick, Abbi M McClintic, Pierre D Mourad, Christoph P Hofstetter
Traumatic spinal cord injury (SCI) often leads to permanent neurological impairment. Currently, the only clinically effective intervention for patients with acute SCI is surgical decompression by removal of impinging bone fragments within 24 h after injury. Recent clinical studies suggest that elevated intraparenchymal spinal pressure (ISP) limits functional recovery following SCI. Here, we report on the temporal and spatial patterns of elevated ISP following a moderate rodent contusion SCI. Compared with physiological ISP in the intact cord (2...
September 27, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27473980/evaluation-of-the-survival-of-bone-marrow-derived-mononuclear-cells-and-the-growth-factors-produced-upon-intramedullary-transplantation-in-rat-models-of-acute-spinal-cord-injury
#20
Kiyotaka Arai, Yasuji Harada, Hiroyuki Tomiyama, Masaki Michishita, Nobuo Kanno, Takuya Yogo, Yoshihisa Suzuki, Yasushi Hara
Intramedullary bone marrow-derived mononuclear cell (BM-MNC) transplantation has demonstrated neuroprotective effects in the chronic stage of spinal cord injury (SCI). However, no previous study has evaluated its effects in the acute stage, even though cell death occurs mainly within 1week after injury in all neuronal cells. Moreover, the mechanism underlying these effects remains unclear. We aimed to investigate the survival of intramedullary transplanted allogeneic BM-MNCs and the production of growth factors after transplantation to clarify the therapeutic potential of intramedullary transplanted BM-MNCs and their protective effects in acute SCI...
August 2016: Research in Veterinary Science
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