keyword
MENU ▼
Read by QxMD icon Read
search

SCI, Immunity

keyword
https://www.readbyqxmd.com/read/29610439/soluble-tnf%C3%AE-signaling-within-the-spinal-cord-contributes-to-the-development-of-autonomic-dysreflexia-and-ensuing-vascular-and-immune-dysfunction-after-spinal-cord-injury
#1
Eugene Mironets, Patrick Osei-Owusu, Valerie Bracchi-Ricard, Roman Fischer, Elizabeth A Owens, Jerome Ricard, Di Wu, Tatiana Saltos, Eileen Collyer, Shaoping Hou, John R Bethea, Veronica J Tom
Cardiovascular disease and susceptibility to infection are leading causes of morbidity and mortality for individuals with spinal cord injury (SCI). A major contributor to these is autonomic dysreflexia (AD), an amplified reaction of the autonomic nervous system (hallmarked by severe hypertension) in response to sensory stimuli below the injury. Maladaptive plasticity of the spinal sympathetic reflex circuit below the SCI results in AD intensification over time. Mechanisms underlying this maladaptive plasticity are poorly understood, restricting the identification of treatments...
April 2, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29558941/perturbing-chondroitin-sulfate-proteoglycan-signaling-through-lar-and-ptp%C3%AF-receptors-promotes-a-beneficial-inflammatory-response-following-spinal-cord-injury
#2
Scott Dyck, Hardeep Kataria, Arsalan Alizadeh, Kallivalappil T Santhosh, Bradley Lang, Jerry Silver, Soheila Karimi-Abdolrezaee
BACKGROUND: Traumatic spinal cord injury (SCI) results in upregulation of chondroitin sulfate proteoglycans (CSPGs) by reactive glia that impedes repair and regeneration in the spinal cord. Degradation of CSPGs is known to be beneficial in promoting endogenous repair mechanisms including axonal sprouting/regeneration, oligodendrocyte replacement, and remyelination, and is associated with improvements in functional outcomes after SCI. Recent evidence suggests that CSPGs may regulate secondary injury mechanisms by modulating neuroinflammation after SCI...
March 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29554835/cervical-spinal-cord-injury-shows-markedly-lower-than-predicted-mortality-72-hours-after-multiple-trauma-from-sepsis-and-multiple-organ-failure
#3
Oliver Kamp, Oliver Jansen, Rolf Lefering, Renate Meindl, Christian Waydhas, Thomas A Schildhauer, Ume Hamsen
BACKGROUND: Sepsis and multiple organ failure (MOF) remain one of the main causes of death after multiple trauma. Trauma- and infection-associated immune reactions play an important role in the pathomechanism of MOF, but the exact pathways remain unknown. Spinal cord injury (SCI) may lead to an altered immune response, and some studies suggest a prognostic advantage for such patients having sepsis or multiple trauma. Yet these findings need to be evaluated in larger cohorts of trauma patients...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29540148/a-protocol-for-custom-crispr-cas9-donor-vector-construction-to-truncate-genes-in-mammalian-cells-using-pcdna3-backbone
#4
Neftali Vazquez, Lilia Sanchez, Rebecca Marks, Eduardo Martinez, Victor Fanniel, Alma Lopez, Andrea Salinas, Itzel Flores, Jesse Hirschmann, Robert Gilkerson, Erin Schuenzel, Robert Dearth, Reginald Halaby, Wendy Innis-Whitehouse, Megan Keniry
BACKGROUND: Clustered regularly interspaced short palindromic repeat (CRISPR) RNA-guided adaptive immune systems are found in prokaryotes to defend cells from foreign DNA. CRISPR Cas9 systems have been modified and employed as genome editing tools in wide ranging organisms. Here, we provide a detailed protocol to truncate genes in mammalian cells using CRISPR Cas9 editing. We describe custom donor vector construction using Gibson assembly with the commonly utilized pcDNA3 vector as the backbone...
March 14, 2018: BMC Molecular Biology
https://www.readbyqxmd.com/read/29500933/treatment-with-interleukin-19-improves-locomotor-functional-recovery-after-contusion-spinal-cord-trauma
#5
Jidong Guo, Huadong Wang, Li Li, Yanli Yuan, Xiuxiu Shi, Shuxun Hou
BACKGROUND AND PURPOSE: Interleukin-19 (IL-19) skews the immune response towards a Th2 type and appears to stimulate angiogenesis. In the current study, we tested if IL-19 treatment could reduce secondary injury and improve functional recovery after contusion spinal cord injury (SCI). EXPERIMENTAL APPROACH: Firstly, mice were given a moderate-severe thoracic SCI at the T9-10 level and expression of IL-19 and its receptor was measured in the injured spinal cord. Then, SCI mice were treated with mouse recombinant IL-19 and its blocking antibody to investigate the therapeutic effect of IL-19...
March 3, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29475438/selective-killing-of-spinal-cord-neural-stem-cells-impairs-locomotor-recovery-in-a-mouse-model-of-spinal-cord-injury
#6
Melania Cusimano, Elena Brambilla, Alessia Capotondo, Donatella De Feo, Antonio Tomasso, Giancarlo Comi, Patrizia D'Adamo, Luca Muzio, Gianvito Martino
BACKGROUND: Spinal cord injury (SCI) is a devastating condition mainly deriving from a traumatic damage of the spinal cord (SC). Immune cells and endogenous SC-neural stem cells (SC-NSCs) play a critical role in wound healing processes, although both are ineffective to completely restore tissue functioning. The role of SC-NSCs in SCI and, in particular, whether such cells can interplay with the immune response are poorly investigated issues, although mechanisms governing such interactions might open new avenues to develop novel therapeutic approaches...
February 23, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29467001/neuregulin-1-elicits-a-regulatory-immune-response-following-traumatic-spinal-cord-injury
#7
Arsalan Alizadeh, Kallivalappil T Santhosh, Hardeep Kataria, Abdelilah S Gounni, Soheila Karimi-Abdolrezaee
BACKGROUND: Spinal cord injury (SCI) triggers a robust neuroinflammatory response that governs secondary injury mechanisms with both degenerative and pro-regenerative effects. Identifying new immunomodulatory therapies to promote the supportive aspect of immune response is critically needed for the treatment of SCI. We previously demonstrated that SCI results in acute and permanent depletion of the neuronally derived Neuregulin-1 (Nrg-1) in the spinal cord. Increasing the dysregulated level of Nrg-1 through acute intrathecal Nrg-1 treatment enhanced endogenous cell replacement and promoted white matter preservation and functional recovery in rat SCI...
February 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29465433/emerging-targets-for-reprograming-the-immune-response-to-promote-repair-and-recovery-of-function-after-spinal-cord-injury
#8
Faith H Brennan, Phillip G Popovich
PURPOSE OF REVIEW: In adult mammals, a traumatic spinal cord injury (SCI) elicits a chronic unregulated neuroinflammatory response accompanied by seemingly paradoxical suppression of systemic immunity. These SCI-induced changes in immune function contribute to poor neurological outcomes and enhanced morbidity or mortality. Nonspecific anti-inflammatory or proinflammatory therapies are ineffective and can even worsen outcomes. Therefore, recent experimental SCI research has advanced the understanding of how neuroimmune cross-talk contributes to spinal cord and systemic pathology...
February 19, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29451216/does-combined-therapy-of-curcumin-and-epigallocatechin-gallate-have-a-synergistic-neuroprotective-effect-against-spinal-cord-injury
#9
Jiri Ruzicka, Lucia Machova Urdzikova, Barbora Svobodova, Anubhav G Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal, Pavla Jendelova
Systematic inflammatory response after spinal cord injury (SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate (EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses (curcumin, 6 mg/kg; EGCG 17 mg/kg)] and weekly intramuscular doses (curcumin, 60 mg/kg; EGCG 17 mg/kg)] for 28 days...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29372458/1h-15n-and-13c-resonance-assignments-of-the-third-domain-from-the-s-aureus-innate-immune-evasion-protein-eap
#10
Alvaro I Herrera, Nicoleta T Ploscariu, Brian V Geisbrecht, Om Prakash
Staphylococcus aureus is a widespread and persistent pathogen of humans and livestock. The bacterium expresses a wide variety of virulence proteins, many of which serve to disrupt the host's innate immune system from recognizing and clearing bacteria with optimal efficiency. The extracellular adherence protein (Eap) is a multidomain protein that participates in various protein-protein interactions that inhibit the innate immune response, including both the complement system (Woehl et al in J Immunol 193:6161-6171, 2014) and Neutrophil Serine Proteases (NSPs) (Stapels et al in Proc Natl Acad Sci USA 111:13187-13192, 2014)...
January 25, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29355694/mechanical-ventilation-modulates-pro-inflammatory-cytokine-expression-in-spinal-cord-tissue-after-injury-in-rats
#11
Karine Truflandier, Eric Beaumont, Emmanuel Charbonney, Karim Maghni, Michel de Marchie, Jadranka Spahija
RATIONALE: Spinal cord injury (SCI) may induce significant respiratory muscle weakness and paralysis, which in turn may cause a patient to require ventilator support. Central nervous system alterations can also exacerbate local inflammatory responses with immune cell infiltration leading to additional risk of inflammation at the injury site. Although mechanical ventilation is the traditional treatment for respiratory insufficiency, evidence has shown that it may directly affect distant organs through systemic inflammation...
April 3, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29317311/concomitant-use-of-mesenchymal-stem-cells-and-neural-stem-cells-for-treatment-of-spinal-cord-injury-a-combo-cell-therapy-approach
#12
Seyed Mojtaba Hosseini, Mahsa Sani, Kh Husnanin Haider, Mohammadreza Dorvash, Seyyed Mohyeddin Ziaee, Aliasghar Karimi, Mohmmad Reza Namavar
with neural stem cells (NSCs) provides a hope to recover the neural damage and compensate for the lost neural structures for restoration of interrupted neural communications above and below the site of injury. However, cell-based therapy approach suffers from many biological barriers and technical caveats which severely hamper the prognosis. The biochemically-rich microenvironment at the site of spinal cord injury (SCI), the continuing neuro-degenerative process and infiltrating immune cells offer a serious barrier to the donor cells...
March 6, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29310515/persons-with-chronic-spinal-cord-injury-have-decreased-natural-killer-cell-and-increased-toll-like-receptor-inflammatory-gene-expression
#13
Paige Herman, Adam Stein, Katie Gibbs, Ilya Korsunsky, Peter Gregersen, Ona Bloom
Infections are the leading cause of death for individuals with traumatic spinal cord injury (SCI). Along with increased infection rates, inflammation is often also observed in persons with chronic SCI. Together, immunological changes post-SCI are also poised to impede neurological recovery and mediate common medical consequences of SCI, including atherogenesis and neuropathic pain. The molecular mechanisms contributing to increased infection susceptibility and inflammation in persons living with SCI are poorly understood...
April 5, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29282251/%C3%AE-%C3%AE-t-cells-provide-the-early-source-of-ifn-%C3%AE-to-aggravate-lesions-in-spinal-cord-injury
#14
Guodong Sun, Shuxian Yang, Guangchao Cao, Qianghua Wang, Jianlei Hao, Qiong Wen, Zhizhong Li, Kwok-Fai So, Zonghua Liu, Sufang Zhou, Yongxiang Zhao, Hengwen Yang, Libing Zhou, Zhinan Yin
Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). γδ T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in γδ T cells ( TCRδ-/- ) showed improved functional recovery after SCI. γδ T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the Vγ4 subtype and express the inflammatory cytokine IFN-γ...
February 5, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29190648/anterior-chamber-associated-immune-deviation-used-as-a-neuroprotective-strategy-in-rats-with-spinal-cord-injury
#15
Beatriz Pineda-Rodriguez, Diana Toscano-Tejeida, Elisa García-Vences, Roxana Rodriguez-Barrera, Adrian Flores-Romero, Daniela Castellanos-Canales, Gabriel Gutierrez-Ospina, Laura Castillo-Carvajal, Esperanza Meléndez-Herrera, Antonio Ibarra
The inflammatory response is probably one of the main destructive events occurring after spinal cord injury (SCI). Its progression depends mostly on the autoimmune response developed against neural constituents. Therefore, modulation or inhibition of this self-reactive reaction could help to reduce tissue destruction. Anterior chamber associated immune deviation (ACAID) is a phenomenon that induces immune-tolerance to antigens injected into the eye´s anterior chamber, provoking the reduction of such immune response...
2017: PloS One
https://www.readbyqxmd.com/read/29176992/immunosenescence-in-persons-with-spinal-cord-injury-in-relation-to-urinary-tract-infections-a-cross-sectional-study
#16
David Pavlicek, Jörg Krebs, Simona Capossela, Alessandro Bertolo, Britta Engelhardt, Jürgen Pannek, Jivko Stoyanov
Background: Individuals with a spinal cord injury (SCI), despite specialized rehabilitation and good health care, have a reduced life expectancy. Infectious diseases, such as pneumonias, infected pressure sores and urinary tract infections (UTI) have been identified as the leading causes of mortality. We hypothesise that a premature onset of immune frailty occurs in SCI, possibly caused also by recurrent urinary tract infections.A cross sectional study was performed comparing blood and urine samples between able bodied controls ( n  = 84) and persons with spinal cord injury ( n  = 85)...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29175543/high-mobility-group-box-1-hmgb1-is-increased-in-injured-mouse-spinal-cord-and-can-elicit-neurotoxic-inflammation
#17
Kristina A Kigerl, Wenmin Lai, Lindsay M Wallace, Huan Yang, Phillip G Popovich
Inflammation is a ubiquitous but poorly understood consequence of spinal cord injury (SCI). The mechanisms controlling this response are unclear but culminate in the sequential activation of resident and recruited immune cells. Collectively, these cells can exert divergent effects on cell survival and tissue repair. HMGB1 is a ubiquitously expressed DNA binding protein and also a potent inflammatory stimulus. Necrotic cells release HGMB1, but HMGB1 also is actively secreted by inflammatory macrophages. A goal of this study was to quantify spatio-temporal patterns of cellular HMGB1 expression in a controlled mouse model of experimental SCI then determine the effects of HMGB1 on post-SCI neuroinflammation and recovery of function...
November 23, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29173165/exploring-promising-immunomodulatory-potential-of-natural-and-synthetic-1-3-diphenyl-2-propen-1-one-analogs-a-review-of-mechanistic-insight
#18
Muhammad Hassan Safdar, Humna Hasan, Sajal Afzal, Zahid Hussain
The immune system is an intricate and coordinated nexus serving as a natural defense to preclude internal and external pathogenic insults. The deregulation in the natural balance of immunological functions as a consequence of either over expression or under expression of immune cells tends to cause disruption of homeostasis in the body and may lead to development of numerous immune system disorders. Chalcone moieties (1,3-diphenyl-2-propen-1-one) have been well-documented as ideal lead compounds or precursors to design a wide range of pharmacologically active agents to down-regulate various immune disorders...
November 23, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29101668/gut-microbiota-are-disease-modifying-factors-after-traumatic-spinal-cord-injury
#19
REVIEW
Kristina A Kigerl, Klauss Mostacada, Phillip G Popovich
Spinal cord injury (SCI) disrupts the autonomic nervous system (ANS), impairing its ability to coordinate organ function throughout the body. Emerging data indicate that the systemic pathology that manifests from ANS dysfunction exacerbates intraspinal pathology and neurological impairment. Precisely how this happens is unknown, although new data, in both humans and in rodent models, implicate changes in the composition of bacteria in the gut (i.e., the gut microbiota) as disease-modifying factors that are capable of affecting systemic physiology and pathophysiology...
January 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29065765/rolipram-loaded-polymeric-micelle-nanoparticle-reduces-secondary-injury-after-rat-compression-spinal-cord-injury
#20
Christian Macks, So-Jung Gwak, Michael Lynn, Jeoung Soo Lee
Among the complex pathophysiological events following spinal cord injury (SCI), one of the most important molecular level consequences is a dramatic reduction in neuronal cyclic adenosine monophosphate (cAMP) levels. Many studies shown that rolipram (Rm), a phosphodiesterase IV inhibitor, can protect against secondary cell death, reduce inflammatory cytokine levels and immune cell infiltration, and increase white matter sparing and functional improvement. Previously, we developed a polymeric micelle nanoparticle, poly(lactide-co-glycolide)-graft-polyethylenimine (PgP), for combinatorial delivery of therapeutic nucleic acids and drugs for SCI repair...
February 1, 2018: Journal of Neurotrauma
keyword
keyword
105793
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"