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Pain in Parkinson's disease

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https://www.readbyqxmd.com/read/29131336/molecular-function-of-%C3%AE-7-nicotinic-receptors-as-drug-targets
#1
Cecilia Bouzat, Matías Lasala, Beatriz Elizabeth Nielsen, Jeremías Corradi, María Del Carmen Esandi
Nicotinic acetylcholine receptors (nAChR) are pentameric ligand-gated ion channels involved in many physiological and pathological processes. In vertebrates, there are seventeen different nAChR subunits that combine to yield a variety of receptors with different pharmacology, function, and localization. The homomeric α7 receptor is one of the most abundant nAChRs in the nervous system and it is also present in non-neuronal cells. It plays important roles in cognition, memory, pain, neuroprotection, and inflammation...
November 13, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29127919/a-case-report-of-a-de-garengeot-hernia-in-a-nonagenarian-veteran
#2
Luis R Taveras, Sergio Huerta
INTRODUCTION: A hernia containing the vermiform appendix [de Garengeot hernia (DGH)] is an exceedingly rare event. Appendicitis occurring in this setting if further unusual. Most cases of DGH are made during inguinal exploration. In the present report, we discuss a patient who underwent an operation which revealed a DGH with appendicitis. PRESENTATION OF A CASE: A 94-year-old man with a past medical history significant for hypertension and Parkinson's disease was admitted to the hospital for the management of an event of CHF exacerbation...
November 3, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29119079/minimizing-nocebo-effect-pragmatic-approach
#3
REVIEW
Majed Chamsi-Pasha, Mohammed Ali Albar, Hassan Chamsi-Pasha
The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy. The frequency of adverse events can dramatically increase by informing patients about the possible side effects of the treatment, and by negative expectations on the part of the patient. Patients who were told that they might experience sexual side effects after treatment with β-blocker drugs reported these symptoms between three and four times more often than patients in a control group who were not informed about these symptoms...
October 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29103291/current-and-future-uses-of-transcranial-focused-ultrasound-in-neurosurgery
#4
David S Hersh, Howard M Eisenberg
Focused ultrasound (FUS) produces a region of high intensity at the focal zone of the beam but with minimal effects at adjacent areas, allowing the sonication of deep targets throughout the body. Despite early obstacles to transmitting ultrasound energy through the skull, recent advances in ultrasound technology, software, and real-time monitoring have resulted in a renewed interest in the clinical applications of transcranial FUS. Following extensive pre- clinical studies, ultrasound-induced thermal ablation has been approved by several countries for the treatment of essential tremor, Parkinson's disease, obsessive-compulsive disorder, depression, and neuropathic pain...
November 3, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29102441/incobotulinum-toxin-a-in-parkinson-s-disease-with-foot-dystonia-a%C3%A2-double-blind-randomized-trial
#5
Isabelle Rieu, Bertrand Degos, Giovanni Castelnovo, Christophe Vial, Elodie Durand, Bruno Pereira, Marion Simonetta-Moreau, Sophie Sangla, Frédérique Fluchère, Dominique Guehl, Pierre Burbaud, Christian Geny, Dominique Gayraud, Fabienne Ory-Magne, Françoise Bouhour, Elisabeth Llinares, Philippe Derost, Ana Marques, Franck Durif
INTRODUCTION: Plantar flexion of toe dystonia is very painful and leads to difficulties in walking. The objective of this study was to investigate the effect of incobotulinum toxin A (Xeomin) in the treatment of this type of dystonia in parkinsonian patients, using a randomized, double blind, placebo-controlled trial. METHODS: 45 parkinsonian patients with painful dystonic plantar flexion of toes were injected either with incobotulinum toxin A (Btx group), or with placebo in two muscle targets: the Flexor digitorum longus and the Flexor digitorum brevis...
October 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29090105/the-outcomes-of-total-hip-replacement-in-patients-with-parkinson-s-disease-comparison-of-the-elective-and-hip-fracture-groups
#6
Pavel Šponer, Tomáš Kučera, Michal Grinac, Aleš Bezrouk, Daniel Waciakowski
INTRODUCTION: The aim of the study was to compare the clinical outcomes following elective and traumatic total hip arthroplasty in Parkinson's disease patients. MATERIALS AND METHODS: Ten patients with osteoarthritis comprise the elective group (mean age at operation 74 years; mean follow-up 82 months). Thirteen patients with femoral fracture comprise the hip fracture group (mean age 76 years; mean follow-up 54 months). All patients were followed up at 6 and 36 months postoperatively and at the time of the latest follow-up...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29069985/neural-autoantibodies-in-patients-with-neurological-symptoms-and-histories-of-chemical-mold-exposures
#7
Mohamed Bahie Abou-Donia, Allan Lieberman, Luke Curtis
A number of studies have linked exposures to industrial and household chemicals and biological toxins to increased risk of autoimmunity in general and elevated levels of autoantibodies to neural antigens specifically. Elevated neural autoantibodies are biomarkers for many diseases such as multiple sclerosis and Parkinson's disease. Our study reports levels of six types of neural autoantibodies in a group of 24 toxicant-exposed patients. The patients were exposed to a variety of toxicants including contaminated drinking water (four patients), building water/mold damage (eight patients), pesticides (four patients), and other assorted toxic chemicals (eight patients)...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29059132/medical-cannabis-in-parkinson-disease-real-life-patients-experience
#8
Yacov Balash, Lihi Bar-Lev Schleider, Amos D Korczyn, Herzel Shabtai, Judith Knaani, Alina Rosenberg, Yehuda Baruch, Ruth Djaldetti, Nir Giladi, Tanya Gurevich
BACKGROUND: The use of medical cannabis (MC) is controversial. Support for its benefits is based on small clinical series. OBJECTIVE: The aim of this study was to report the results of a standardized interview study that retrospectively assessed the effects of MC on symptoms of Parkinson disease (PD) and its adverse effects in patients treated for at least 3 months. METHODS: The survey used telephone interviews using a structured questionnaire based on subjective global impressions of change for various parkinsonian symptoms and yes/no questions on adverse effects...
November 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29037787/the-relationship-between-spinal-pain-and-comorbidity-a-cross-sectional-analysis-of-579-community-dwelling-older-australian-women
#9
Katie E de Luca, Lynne Parkinson, Scott Haldeman, Julie E Byles, Fiona Blyth
OBJECTIVES: The aims of this study were to (1) report the prevalence and explore the influence of spinal pain on quality of life and (2) assess the relationship between spinal pain and the type and number of comorbidities. METHODS: This cross-sectional study comprised 579 community-dwelling, older Australian women. Women had "spinal pain" if they marked "yes" to neck pain, upper back pain, mid-back pain, and/or lower back pain. Descriptive statistics and binary logistic regression were performed to report the prevalence and explore the relationship between spinal pain and the type and number of comorbidities...
October 13, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29032408/the-natural-history-of-depressive-symptoms-in-patients-with-incident-parkinson-s-disease-a-prospective-cohort-study
#10
Jan Petter Larsen, Ingvild Dalen, Kenn Freddy Pedersen, Ole-Bjørn Tysnes
Depression is common in patients with Parkinson disease and causes suffering and increased caregiver burden. A better understanding of depressive symptoms in Parkinson disease, their progression, and risk factors may, therefore, benefit management of these patients. The present study included 187 drug-naïve patients with incident PD and 166 controls from the population-based Norwegian ParkWest project. Depressive symptoms were examined with the Montgomery and Aasberg Depression Rating Scale (MADRS) at time of diagnosis and inclusion in the study and after 1, 3, 5, and 7 years of follow-up...
October 14, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29031913/chronic-pain-and-pain-processing-in-parkinson-s-disease
#11
REVIEW
Pierre J Blanchet, Christine Brefel-Courbon
Pain is experienced by the vast majority of patients living with Parkinson's disease. It is most often of nociceptive origin, but may also be ascribed to neuropathic (radicular or central) or miscellaneous sources. The recently validated King's Parkinson's Disease Pain Scale is based on 7 domains including musculoskeletal pain, chronic body pain (central or visceral), fluctuation-related pain, nocturnal pain, oro-facial pain, pain with discolouration/oedema/swelling, and radicular pain. The basal ganglia integrate incoming nociceptive information and contribute to coordinated motor responses in pain avoidance and nocifensive behaviors...
October 12, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29020715/diagnosis-and-management-of-polymyalgia-rheumatica
#12
REVIEW
Olwyn Jones, Fraser Birrell
Polymyalgia rheumatica (PMR) is a common inflammatory condition of unknown aetiology with a prevalence of 1 in 133 in the over 50s, and a female to male ratio of 2:1. Symptoms develop over a matter of weeks; typically bilateral shoulder or pelvic girdle pain and stiffness, that is worse in the mornings. Associated symptoms include low-grade fever, malaise, fatigue, low mood, poor appetite, and weight loss. There is no specific diagnostic test for PMR but the usual pattern is a commensurate rise in CRP and ESR...
December 2016: Practitioner
https://www.readbyqxmd.com/read/28993732/purinergic-signalling-therapeutic-developments
#13
REVIEW
Geoffrey Burnstock
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990's when receptor subtypes for purines and pyrimidines were cloned and characterised, which includes four subtypes of the P1 (adenosine) receptor, seven subtypes of P2X ion channel receptors and 8 subtypes of the P2Y G protein-coupled receptor. Early studies were largely concerned with the physiology, pharmacology and biochemistry of purinergic signalling...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28988834/predictive-model-for-health-related-quality-of-life-in-patients-with-parkinson-s-disease
#14
Sook Ja Lee, Sung Reul Kim, Sun Ju Chung, Hyun Cheol Kang, Mi Sun Kim, Su-Jin Cho, Hye Kyung Kwon, Jungwon Kim, Sun Young Jung
This study was conducted to develop and test a prediction model that explains health-related quality of life (HRQoL) of patients with Parkinson's disease (PD). Participants were 248 patients with PD enrolled in the neurology clinic of a university hospital in Seoul, Korea. The data were collected through structured questionnaires from March 1 to July 5, 2013. Motor fluctuations, depression, sleep disturbances, fatigue, and activities of daily living had significant direct effects on the quality of life of PD patients...
October 5, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28949252/pharmacological-therapies-for-pain-in-parkinson-s-disease-a-review-paper
#15
Abdul Qayyum Rana, Danial Qureshi, Walid Sabeh, Abdullah Mosabbir, Eraad Rahman, Zainab Sarfraz, Ruqqiyah Rana
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopamine containing cells in the substantia nigra, with pain being one of the most common, yet frequently misunderstood symptoms. The prevalence of pain in PD populations ranges from 40-85% and is usually categorized under the following types: i) musculoskeletal pain ii) radicular and neuropathic pain iii) dystonia-related pain iv) akathitic pain and iv) central parkinsonian pain. Areas covered: The aim of this literature review was to document and present the common and uncommon pharmaceutical therapies that treat and/or alleviate these types of pain in PD...
October 4, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28948058/reverse-total-shoulder-arthroplasty-as-treatment-for-rotator-cuff-tear-arthropathy-and-shoulder-dislocations-in-an-elderly-male-with-parkinson-s-disease
#16
John G Skedros, James S Smith, Tanner D Langston, Micheal G Adondakis
We report the case of a 70-year-old male with Parkinson's disease (PD) and recurrent traumatic left shoulder dislocations. This case is rare because (1) he had a massive irreparable rotator cuff tear and end-stage arthritis (i.e., rotator cuff-tear arthropathy) of the same shoulder and (2) his shoulder was ultimately reconstructed with a reverse total shoulder arthroplasty (RTSA). His first dislocation occurred after a fall. Recurrent shoulder dislocations occurred despite successful closed reduction and physical therapy...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28946570/effects-of-postural-exercises-in-patients-with-parkinson-s-disease-and-pisa-syndrome-a-pilot-study
#17
Francesco Lena, Ennio Iezzi, Mohammad Etoom, Marco Santilli, Diego Centonze, Calogero Foti, Giovanni Grillea, Nicola Modugno
BACKGROUND: Pisa syndrome (PS) or lateral axial dystonia is often seen in patients with Parkinson's disease (PD). It is characterized by a marked and reversible lateral flexion of the trunk (LFT) more than 10°. OBJECTIVE: To assess the effectiveness of a program of postural exercises and assess the effectiveness in term of pattern of muscular hyperactivity. METHODS: A total of 6 patients with PD and PS enrolled in the program of 10 sessions of postural exercise (90 min/session)...
2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28944983/oral-prolonged-release-oxycodone-naloxone-for-managing-pain-and-opioid-induced-constipation-a-review-of-the-evidence
#18
REVIEW
Bart J Morlion, Stefan A Mueller-Lissner, Renato Vellucci, Wojciech Leppert, Benoît C Coffin, Sara L Dickerson, Tony O'Brien
BACKGROUND: Opioids provide effective relief from moderate-to-severe pain and should be prescribed as part of a multifaceted approach to pain management when other treatments have failed. Fixed-dose oxycodone/naloxone prolonged-release tablets (OXN PR) were designed to address the opioid class effect of opioid-induced constipation (OIC) by combining the analgesic efficacy of oxycodone with the opioid receptor antagonist, naloxone, which has negligible systemic availability when administered orally...
September 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28912900/open-label-trial-of-the-efficacy-and-safety-profile-of-rikkunshito-used-for-the-treatment-of-gastrointestinal-symptoms-in-patients-with-parkinson-s-disease-a-pilot-study
#19
Koji Yakabi, Naomi Yamaguchi, Shino Ono, Norihito Yoshida, Eriko Hosomi, Kenjiro Hayashi, Mitsuko Ochiai, Kosuke Maezawa, Kyoichi Nomura
BACKGROUND: Patients with Parkinson's disease (PD) usually experience distress related not only to motor dysfunction, but also to nonmotor symptoms, including gastrointestinal dysfunction. OBJECTIVE: The purpose of this pilot study was to evaluate the efficacy and safety profile of a traditional Japanese medicine, rikkunshito (RKT), used for the treatment of gastrointestinal symptoms, associated with anorexia and dyspepsia, in patients with PD. METHODS: Patients were randomly assigned to either Group A (4-week treatment period with 7...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28904969/sociodemographic-and-clinical-characteristics-of-centenarians-in-mexico-city
#20
Valdés-Corchado Pedro, Ruiz-Hernández Arturo, Pérez-Moreno Alejandro, Rosas-Carrasco Oscar
BACKGROUND: There is little evidence about the demography and health status of adults aged 100 years and over in Latin America and there are no studies in Mexico. OBJECTIVES: To describe the demographic characteristics and health status of centenarians residing in Mexico City. METHODS: This is a cross-sectional study using a population base of 393 community-dwelling centenarians in Mexico City. A comprehensive geriatric assessment was performed, including demographic information and health status...
2017: BioMed Research International
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