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Pain in Parkinson's disease

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https://www.readbyqxmd.com/read/28056455/the-association-of-musculoskeletal-pain-with-bone-mineral-density-in-patients-with-parkinson-s-disease
#1
Seong-Min Choi, Byeong C Kim, Hyun-Jung Jung, Geum-Jin Yoon, Kyung Wook Kang, Kang-Ho Choi, Seung-Han Lee, Man-Seok Park, Myeong-Kyu Kim, Ki-Hyun Cho
BACKGROUND: Pain and osteoporosis are common in Parkinson's disease (PD), and lower bone mineral density (BMD) or osteoporosis may be associated with an increased risk of reporting to have pain in the general population. The aim of this study was to determine whether there is an association between the pain subtypes and the BMD in patients with PD. METHODS: We included 162 PD patients. Pain was assessed using the patients' descriptions, a structured interview, a detailed neurologic examination, and the Visual Analogue Scale...
January 5, 2017: European Neurology
https://www.readbyqxmd.com/read/28018168/what-mechanisms-are-responsible-for-the-reuptake-of-levodopa-derived-dopamine-in-parkinsonian-striatum
#2
REVIEW
Haruo Nishijima, Masahiko Tomiyama
Levodopa is the most effective medication for motor symptoms in Parkinson's disease. However, various motor and non-motor complications are associated with levodopa treatment, resulting from altered levodopa-dopamine metabolism with disease progression and long-term use of the drug. The present review emphasizes the role of monoamine transporters other than the dopamine transporter in uptake of extracellular dopamine in the dopamine-denervated striatum. When dopaminergic neurons are lost and dopamine transporters decreased, serotonin and norepinephrine transporters compensate by increasing uptake of excessive extracellular dopamine in the striatum...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28001292/predictors-for-unplanned-hospitalization-of-new-home-care-clients
#3
Jukka K Rönneikkö, Matti Mäkelä, Esa R Jämsen, Heini Huhtala, Harriet Finne-Soveri, Anja Noro, Jaakko N Valvanne
OBJECTIVES: To identify factors predicting unplanned hospitalization of new home care clients using the Resident Assessment Instrument for Home Care (RAI-HC). DESIGN: A register-based study based on RAI-HC assessments and nationwide hospital discharge records. SETTING: Municipal home care services in Finland. PARTICIPANTS: New Finnish home care clients aged 63 and older (N = 15,700). MEASUREMENTS: Information from home care clients' first RAI-HC assessment was connected to information regarding their first hospitalization over 1 year of follow-up...
December 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27994829/severe-cold-lower-limbs-in-patients-with-parkinson-s-disease-during-the-summer
#4
Hiroshi Kataoka, Satoshi Ueno
Parkinson's disease (PD) is frequently associated with vasomotor symptoms such as distal cold limbs or sensitivity to cold. Coldness of the lower limbs (COL) usually occurs in winter and is often accompanied by pain, potentially causing difficulty in walking or standing. A standard dopaminergic treatment for such symptoms is yet to be established. We describe two patients with PD, who had severe COL during summer. For example, the patients wore many pairs of socks or used heating appliances in the summer. Severe COL can occur in summertime and can be intolerable or unpleasant, since it can worsen disability...
November 2, 2016: Neurology International
https://www.readbyqxmd.com/read/27993522/non-motor-symptoms-and-the-quality-of-life-in-multiple-system-atrophy-with-different-subtypes
#5
LingYu Zhang, Bei Cao, RuWei Ou, Qian-Qian Wei, Bi Zhao, Jing Yang, Ying Wu, HuiFang Shang
BACKGROUND: The differences in non-motor symptoms (NMS) and quality of life (QOL) between MSA patients with different subtypes remain unknown, so do the determinants of poor QOL in both subtypes. METHODS: A total of 172 MSA patients were enrolled in the study. NMS of patients with MSA were assessed using the non-motor symptoms scale (NMSS) and Parkinson's Disease Questionnaire-39 item version (PDQ-39) was used to evaluate the QOL of patients with MSA. RESULTS: The most prevalent NMS domain was urinary (91...
December 13, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27984022/effects-of-subthalamic-deep-brain-stimulation-with-duloxetine-on-mechanical-and-thermal-thresholds-in-6ohda-lesioned-rats
#6
Brian C Kaszuba, Ian Walling, Lucy E Gee, Damian S Shin, Julie G Pilitsis
Chronic pain is the most common non-motor symptom of Parkinson's disease (PD) and is often overlooked. Unilateral 6-hydroxydopamine (6-OHDA) medial forebrain bundle lesioned rats used as models for PD exhibit decreased sensory thresholds in the left hindpaw. Subthalamic deep brain stimulation (STN DBS) increases mechanical thresholds and offers improvements with chronic pain in PD patients. However, individual responses to STN high frequency stimulation (HFS) in parkinsonian rats vary with 58% showing over 100% improvement, 25% showing 30-55% improvement, and 17% showing no improvement...
January 15, 2017: Brain Research
https://www.readbyqxmd.com/read/27964875/characteristics-of-spinopelvic-alignment-in-parkinson-s-disease-comparison-with-adult-spinal-deformity
#7
Kei Watanabe, Toru Hirano, Keiichi Katsumi, Masayuki Ohashi, Hirokazu Shoji, Kazuhiro Hasegawa, Akiyoshi Yamazaki, Atsushi Ishikawa, Ryoko Koike, Naoto Endo, Masatoyo Nishizawa, Takayoshi Shimohata
PURPOSE: The characteristics and pathogenesis of spinopelvic alignment in Parkinsons's disease (PD) patients-including differences compared to non-PD subjects and their relationships with the severity of PD-have not been clarified. The aim of this study was to investigate the characteristics of spinopelvic alignment in patients with PD. METHODS: Forty-eight PD patients complaining of chronic low back pain were included (PD group). The PD condition, determined using the Hoehn and Yahr (H&Y) stage and Unified Parkinson Disease Rating Scale (UPDRS) score; radiographic spinopelvic alignment; lumbar range of motion (ROM); and low back pain-related quality of life assessments were evaluated...
December 10, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27959284/the-proposed-use-of-cervical-spinal-cord-stimulation-for-the-treatment-and-prevention-of-cognitive-decline-in-dementias-and-neurodegenerative-disorders
#8
Nestor D Tomycz
Cervical spinal cord stimulation is a well-established treatment for intractable neuropathic upper extremity pain. More than 20years ago it was demonstrated that cervical spinal cord stimulation could engender an increase in cerebral blood flow. Cerebral blood flow has been shown to be decreased in many patients with dementia and in various neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Furthermore, there is evidence that reduced cerebral blood flow worsens neurodegenerative disease and may also predict which patients progress from mild cognitive impairment to full blown Alzheimer's disease...
November 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27956826/nonmotor-gastrointestinal-disorders-in-older-patients-with-parkinson-s-disease-is-there-hope
#9
Doina Georgescu, Oana Elena Ancusa, Liviu Andrei Georgescu, Ioana Ionita, Daniela Reisz
Despite the fact that nonmotor symptoms (NMS) like gastrointestinal (GI) complaints are frequently reported in Parkinson's disease (PD), no therapeutic guidelines are available. This study aimed to manage some lower GI-NMS in a group of patients with PD. A total of 40 patients (17 males, 23 females; mean age 76.05±2.09 years) were randomly selected for this study. Patients were confirmed to have PD (modified Hoehn-Yars scale: 2.075±0.4) who had undergone levodopa or dopamine agonist treatment. In the non-motor symptoms questionnaire (NMS-Quest), regarding GI complaints, the following were recorded: abdominal pain, bloating, and constipation of mild-to-moderate severity...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27939325/the-efficacy-of-apomorphine-a-non-motor-perspective
#10
Miguel Rosa-Grilo, Mubasher A Qamar, Andrew Evans, K Ray Chaudhuri
Non-motor features have a great impact on progression and quality of life in individuals with Parkinson's disease. Current treatments for PD are limited and apomorphine is one of the advanced therapies available with advantageous effects on motor complications. Several studies have suggested that apomorphine has potential benefits in PD patients beyond its established role in the treatment of motor fluctuations and levodopa-induced dyskinesia. This review examines the efficacy of apomorphine in the treatment of non-motor symptoms (NMS), describing recent studies that highlight its possible effect on cognition...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27938485/neuroprotection-of-granulocyte-colony-stimulating-factor-for-early-stage-parkinson%C3%A2-s-disease
#11
Sheng-Tzung Tsai, Sung-Chao Chu, Shu-Hsin Liu, Cheng-Yoong Pang, TingWen Hou, Shinn-Zong Lin, Shin-Yuan Chen
Parkinson’s disease (PD) is a slowly progressive neurodegenerative disease. Both medical and surgical choicesprovide symptomatic treatment. Granulocyte colonystimulating factor (G-CSF), a conventional treatment for hematological diseases, has demonstrated its effectiveness in acute and chronic neurological diseases through its anti-inflammatory and anti-apoptosis mechanisms. Based on previous <em>in vitro</em> and <em>in vivo</em> studies, we administered a lower-dose (3.3 µg/kg) G-CSF injection for five days and six courses during one year in early stage PD patients as a phase I trial...
7, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27902448/rasgrp1-promotes-amphetamine-induced-motor-behavior-through-a-rhes-interaction-network-rhesactome-in-the-striatum
#12
Neelam Shahani, Supriya Swarnkar, Vincenzo Giovinazzo, Jenny Morgenweck, Laura M Bohn, Catherina Scharager-Tapia, Bruce Pascal, Pablo Martinez-Acedo, Kshitij Khare, Srinivasa Subramaniam
The striatum of the brain coordinates motor function. Dopamine-related drugs may be therapeutic to patients with striatal neurodegeneration, such as Huntington's disease (HD) and Parkinson's disease (PD), but these drugs have unwanted side effects. In addition to stimulating the release of norepinephrine, amphetamines, which are used for narcolepsy and attention-deficit/hyperactivity disorder (ADHD), trigger dopamine release in the striatum. The guanosine triphosphatase Ras homolog enriched in the striatum (Rhes) inhibits dopaminergic signaling in the striatum, is implicated in HD and L-dopa-induced dyskinesia, and has a role in striatal motor control...
November 15, 2016: Science Signaling
https://www.readbyqxmd.com/read/27883297/patients-perception-of-parkinson-s-disease-associated-pain-following-initiation-of-rotigotine-a-multicenter-non-interventional-study
#13
Lars Timmermann, Christian Oehlwein, Gerhard Ransmayr, Holger Fröhlich, Edgar Will, Hanna Schroeder, Thomas Lauterbach, Lars Bauer, Jan Kassubek
OBJECTIVES: To evaluate Parkinson's disease (PD)-associated pain as perceived by the patients (subjective characterization), and how this may change following initiation of rotigotine transdermal patch. METHODS: SP1058 was a non-interventional study conducted in routine clinical practice in Germany and Austria in patients experiencing PD-associated pain (per the physician's assessment). Data were collected at baseline (ie, before rotigotine initiation) and at a routine visit after ≥25 days (-3 days allowed) of treatment on a maintenance dose of rotigotine (end of study [EoS])...
November 24, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27879550/successful-treatment-of-brachial-plexopathy-due-to-herpes-zoster-infection-with-intravenous-immunoglobulin
#14
Michel Sáenz-Farret, Valeria Sandoval-Rodríguez, Claudia Esther Paz-Navarro, Carlos Zúñiga-Ramírez
OBJECTIVE: The aim of this study was to report the case of a male patient with Parkinson disease who developed brachial plexopathy (BP) due to varicella-zoster virus, which was successfully treated with human immunoglobulin. METHOD: We report the case of a 75-year-old male subject with a diagnosis of Parkinson disease who came to our hospital complaining of pain, skin lesions, and strength loss in his right arm during the past 2 months. Physical examination revealed vesicular rash compatible with varicella-zoster virus lesions...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27874939/health-status-correlates-of-malnutrition-in-the-polish-elderly-population-results-of-the-polsenior-study
#15
R Krzyminska-Siemaszko, J Chudek, A Suwalska, M Lewandowicz, M Mossakowska, R Kroll-Balcerzak, B Wizner, S Tobis, K Mehr, K Wieczorowska-Tobis
OBJECTIVE: The aim of the study was to analyze health-related factors associated with poor nutritional status (PNS) of a representative group of Polish older people, based on data from the PolSenior project (the first nation-wide study of Polish senior citizens). PATIENTS AND METHODS: Nutritional status was assessed in 3751 community-dwelling older people (1770 females, mean age: 77.4±8.0 years) using the Mini Nutritional Assessment - Short Form. Elements of comprehensive geriatric assessment (cognitive and mood screening), selected medical data were analyzed in relation to the nutritional status...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27871509/a-cross-sectional-study-of-preoperative-medication-adherence-and-early-postoperative-recovery
#16
Anthony P Notaras, Elisabeth Demetriou, Jessica Galvin, Erez Ben-Menachem
STUDY OBJECTIVE: To quantify the impact of preoperative medication adherence on recovery length of stays and complication rates. DESIGN: Cross-sectional analytical study. SETTING: Postanesthetic care unit (PACU) of a single-center tertiary hospital. PATIENTS: Surgical patients admitted for surgery at our institution over a 4-month period. INTERVENTION: A data collection tool was used to collect demographic data, length of stay in recovery, prespecified conditions likely to impact on PACU recovery (chronic pain, insulin-dependent diabetes, epilepsy, hypertension, on a methadone program, and Parkinson disease), medication compliance, and complications in PACU...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27866120/evidence-based-guidelines-on-the-therapeutic-use-of-transcranial-direct-current-stimulation-tdcs
#17
REVIEW
Jean-Pascal Lefaucheur, Andrea Antal, Samar S Ayache, David H Benninger, Jérôme Brunelin, Filippo Cogiamanian, Maria Cotelli, Dirk De Ridder, Roberta Ferrucci, Berthold Langguth, Paola Marangolo, Veit Mylius, Michael A Nitsche, Frank Padberg, Ulrich Palm, Emmanuel Poulet, Alberto Priori, Simone Rossi, Martin Schecklmann, Sven Vanneste, Ulf Ziemann, Luis Garcia-Larrea, Walter Paulus
A group of European experts was commissioned by the European Chapter of the International Federation of Clinical Neurophysiology to gather knowledge about the state of the art of the therapeutic use of transcranial direct current stimulation (tDCS) from studies published up until September 2016, regarding pain, Parkinson's disease, other movement disorders, motor stroke, poststroke aphasia, multiple sclerosis, epilepsy, consciousness disorders, Alzheimer's disease, tinnitus, depression, schizophrenia, and craving/addiction...
January 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27865707/a-comprehensive-database-of-published-tdcs-clinical-trials-2005-2016
#18
REVIEW
Jean-Pascal Lefaucheur
Transcranial direct current stimulation (tDCS) is a technique of noninvasive cortical stimulation allowing significant modification of brain functions. Clinical application of this technique was reported for the first time in March 2005. This paper presents a detailed list of the 340 articles (excluding single case reports) which have assessed the clinical effect of tDCS in patients, at least when delivered to cortical targets. The reviewed conditions were: pain syndromes, Parkinson's disease, dystonia, cerebral palsy, post-stroke limb motor impairment, post-stroke neglect, post-stroke dysphagia, post-stroke aphasia, primary progressive aphasia, multiple sclerosis, epilepsy, consciousness disorders, Alzheimer's disease and other types of dementia, tinnitus, depression, auditory hallucinations and negative symptoms of schizophrenia, addiction and craving, autism, and attention disorders...
December 2016: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/27855635/prevalence-and-incidence-of-neurological-disorders-among-adult-ugandans-in-rural-and-urban-mukono-district-a-cross-sectional-study
#19
Mark Kaddumukasa, Leviticus Mugenyi, Martin N Kaddumukasa, Edward Ddumba, Michael Devereaux, Anthony Furlan, Martha Sajatovic, Elly Katabira
BACKGROUND: The burden of neurological diseases is increasing in developing countries. However, there is a prominent scarcity of literature on the incidence of neurological diseases in sub-Saharan Africa. This study was therefore undertaken to determine the prevalence and incidence of neurological diseases in this setting to serve as a baseline for planning and care for neurological disorders in Uganda. METHODS: The study was conducted within rural and urban Mukono district, east of Kampala city of Uganda, central region...
November 17, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27836714/abnormal-nociceptive-processing-occurs-centrally-and-not-peripherally-in-pain-free-parkinson-disease-patients-a-study-with-laser-evoked-potentials
#20
Sandro Zambito-Marsala, Roberto Erro, Ruggero Bacchin, Annalisa Fornasier, Federico Fabris, Cecilia Lo Cascio, Franco Ferracci, Francesca Morgante, Michele Tinazzi
BACKGROUND: Several studies documented abnormal nociceptive processing in PD patients. Pain central pathways are accessible by laser-evoked potentials (LEPs). LEPs recording show a N2/P2 complex mostly generated by the anterior cingulate cortex, preceded by an earlier negative component (N1), originating from the opercular cortex. Previous work demonstrated N2/P2 amplitude reduction in PD patients and suggested a centrally-acting pathomechanism for the genesis of pain. However, since a peripheral deafferentation has been recently demonstrated in PD, it is not clear if such LEP abnormalities reflect a mechanism acting centrally or not...
January 2017: Parkinsonism & related Disorders
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