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https://www.readbyqxmd.com/read/27890558/ask1-regulates-the-survival-of-neuroblastoma-cells-by-interacting-with-tlx-and-stabilizing-hif-1%C3%AE
#1
Praveen K Sobhan, Qiwei Zhai, Lydia C Green, Loen M Hansford, Keiko Funa
Elevated expression of TLX (also called as NR2E1) in neuroblastoma (NB) correlates with unfavorable prognosis, and TLX is required for self-renewal of NB cells. Knockdown of TLX has been shown to reduce the NB sphere-forming ability. ASK1 (MAP3K5) and TLX expression are both enhanced in SP (side population) NB and patient-derived primary NB sphere cell lines, but the majority of non-SP NB lines express lower ASK1 expression. We found that ASK1 phosphorylated and stabilized TLX, which led induction of HIF-1α, and its downstream VEGF-A in an Akt dependent manner...
November 23, 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27869172/a-redox-state-dictated-signalling-pathway-deciphers-the-malignant-cell-specificity-of-cd40-mediated-apoptosis
#2
C J Dunnill, K Ibraheem, A Mohamed, J Southgate, N T Georgopoulos
CD40, a member of the tumour necrosis factor receptor (TNFR) superfamily, has the capacity to cause extensive apoptosis in carcinoma cells, while sparing normal epithelial cells. Yet, apoptosis is only achieved by membrane-presented CD40 ligand (mCD40L), as soluble receptor agonists are but weakly pro-apoptotic. Here, for the first time we have identified the precise signalling cascade underpinning mCD40L-mediated death as involving sequential TRAF3 stabilisation, ASK1 phosphorylation, MKK4 (but not MKK7) activation and JNK/AP-1 induction, leading to a Bak- and Bax-dependent mitochondrial apoptosis pathway...
November 21, 2016: Oncogene
https://www.readbyqxmd.com/read/27858941/block-one-unleash-a-hundred-mechanisms-of-dab2ip-inactivation-in-cancer
#3
REVIEW
Arianna Bellazzo, Giulio Di Minin, Licio Collavin
One of the most defining features of cancer is aberrant cell communication; therefore, a molecular understanding of the intricate network established among tumor cells and their microenvironment could significantly improve comprehension and clinical management of cancer. The tumor suppressor DAB2IP (Disabled homolog 2 interacting protein), also known as AIP1 (ASK1 interacting protein), has an important role in this context, as it modulates signal transduction by multiple inflammatory cytokines and growth factors...
November 18, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27826954/critical-and-diverse-in-vivo-roles-of-apoptosis-signal-regulating-kinase-1-in-animal-models-of-atherosclerosis-and-cholestatic-liver-injury
#4
REVIEW
Sohsuke Yamada, Hirotsugu Noguchi, Akihide Tanimoto
Apoptosis plays pivotal in vivo roles in not only vital processes, such as cell turnover and embryonic development, but also various inflammatory disorders. However, the role of apoptosis by vascular and hepatic cells in the respective progression of atherosclerosis and liver injury remains controversial. Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase family member that is activated through distinct mechanisms in response to various cytotoxic stressors. ASK1, ubiquitously expressed, is situated in an important upstream position for many signal transduction pathways, which subsequently induce inflammation and/or apoptosis...
November 9, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27825085/akt2-inhibition-of-cisplatin-induced-jnk-p38-and-bax-activation-by-phosphorylation-of-ask1-implication-of-akt2-in-chemoresistance
#5
Zeng-Qiang Yuan, Richard I Feldman, Gene E Sussman, Domenico Coppola, Santo V Nicosia, Jin Q Cheng
No abstract text is available yet for this article.
October 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27787596/overexpression-of-psk1-a-skp1-like-gene-homologue-from-paeonia-suffruticosa-confers-salinity-tolerance-in-arabidopsis
#6
Qing Hao, Hongxu Ren, Jin Zhu, Liangsheng Wang, Shouchen Huang, Zheng'an Liu, Zhimin Gao, Qingyan Shu
Our study is the first to demonstrate that PSK1 , a SKP1 -like gene homologue, is involved in salinity tolerance. Our functional characterization of PSK1 provides new insights into tree peony development. A homologous gene of S-phase kinase-associated protein1 (SKP1) was cloned from tree peony (Paeonia suffruticosa) and denoted as PSK1. The 462-bp open reading frame of PSK1 was predicted to encode a protein comprising 153 amino acids, with a molecular mass of 17 kDa. The full-length gene was 1,634 bp long and included a large 904-bp intron...
October 27, 2016: Plant Cell Reports
https://www.readbyqxmd.com/read/27785931/role-of-glutathione-s-transferases-in-neurological-problems
#7
Anil Kumar, Dinesh K Dhull, Varun Gupta, Priyanka Channana, Arti Singh, Manveen Bhardwaj, Poonam Ruhal, Ruchika Mittal
Role of Glutathione-S-transferases (GSTs) has been well explored in the cellular detoxification process, regulation of redox homeostasis and S-glutothionylation of target proteins like JNK, ASK1 etc. However, altered levels or functions of this enzyme or their subtypes have emerged in the development of several pathologies diseases such as Alzheimer's disease, Parkinson's disease, cancer and related conditions. Oxidative stress is one of the possible pathological events that contributes significantly to activation of degenerating cascades inside neuronal cells...
October 27, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27775615/microrna-mediated-down-regulation-of-apoptosis-signal-regulating-kinase-1-ask1-attenuates-the-apoptosis-of-human-mesenchymal-stem-cells-mscs-transplanted-into-infarcted-heart
#8
Chang Youn Lee, Sunhye Shin, Jiyun Lee, Hyang-Hee Seo, Kyu Hee Lim, Hyemin Kim, Jung-Won Choi, Sang Woo Kim, Seahyung Lee, Soyeon Lim, Ki-Chul Hwang
Stem cell therapy using adult stem cells, such as mesenchymal stem cells (MSCs) has produced some promising results in treating the damaged heart. However, the low survival rate of MSCs after transplantation is still one of the crucial factors that limit the therapeutic effect of stem cells. In the damaged heart, oxidative stress due to reactive oxygen species (ROS) production can cause the death of transplanted MSCs. Apoptosis signal-regulating kinase 1 (ASK1) has been implicated in the development of oxidative stress-related pathologic conditions...
October 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27762484/-non-haemolytic-enterotoxin-nhe-of-bacillus-cereus-induces-apoptosis-in-vero-cells
#9
Xiaoye Liu, Shuangyang Ding, Peijie Shi, Richard Dietrich, Erwin Märtlbauer, Kui Zhu
Bacillus cereus is an opportunistic pathogen that often causes foodborne infectious diseases and food poisoning. Non-haemolytic enterotoxin (Nhe) is the major toxin found in almost all enteropathogenic B. cereus and B. thuringiensis isolates. However, little is known about the cellular response after Nhe triggered pore formation on cell membrane. Here we demonstrate that Nhe induced cell cycle arrest at G0 /G1 phase and provoked apoptosis in Vero cells, most likely associated with mitogen-activated protein kinase (MAPK) and death receptor pathways...
October 20, 2016: Cellular Microbiology
https://www.readbyqxmd.com/read/27746696/induction-of-nrf2-are-mediated-cytoprotective-genes-by-red-ginseng-oil-through-ask1-mkk4-7-jnk-and-p38-mapk-signaling-pathways-in-hepg2-cells
#10
Min Ji Bak, Van-Long Truong, Se-Yeon Ko, Xuan Ngan Giang Nguyen, Mira Jun, Soon-Gi Hong, Jong-Won Lee, Woo-Sik Jeong
BACKGROUND: The induction of cellular defensive genes such as phase II detoxifying and antioxidant enzymes is a highly effective strategy for protection against carcinogenesis as well as slowing cancer development. Transcription factor Nrf2 (nuclear factor E2-related factor 2) is responsible for activation of phase II enzymes induced by natural chemopreventive compounds. METHODS: Red ginseng oil (RGO) was extracted using a supercritical CO2 extraction system and chemical profile of RGO was investigated by GC/MS...
October 2016: Journal of Ginseng Research
https://www.readbyqxmd.com/read/27741419/endophilin-a2-mediated-increase-in-scavenger-receptor-expression-contributes-to-macrophage-derived-foam-cell-formation
#11
Er-Wen Huang, Can-Zhao Liu, Si-Jia Liang, Zheng Zhang, Xiao-Fei Lv, Jie Liu, Jia-Guo Zhou, Yong-Bo Tang, Yong-Yuan Guan
BACKGROUND AND AIMS: Macrophage-derived foam cell formation (MFCF) is a crucial step in the pathogenesis of atherosclerosis. Uptake of oxidized low-density lipoprotein (oxLDL) by scavenger receptors is indispensable for MFCF. Endophilin-A2 has been reported to regulate clathrin-mediated endocytosis (CME). In this study, we tested the hypothesis that endophilin-A2 regulates oxLDL uptake and MFCF by mediating CME of oxLDL-scavenger receptor complexes. METHODS: In vitro MFCF was induced by oxLDL treatment...
October 6, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27721984/ask1-controls-spindle-orientation-and-positioning-by-phosphorylating-eb1-and-stabilizing-astral-microtubules
#12
Youguang Luo, Jie Ran, Songbo Xie, Yunfan Yang, Jie Chen, Shanshan Li, Wenqing Shui, Dengwen Li, Min Liu, Jun Zhou
Orientation and positioning of the mitotic spindle are involved in dictating cell division axis and cleavage site, and play important roles in cell fate determination and tissue morphogenesis. However, how spindle movement is controlled to achieve a defined alignment within the dividing cell is not fully understood. Here, we describe an unexpected role for apoptosis signal-regulating kinase 1 (ASK1) in regulating spindle behavior. We find that ASK1 is required for proper mitotic progression and daughter cell adhesion to the substratum...
2016: Cell Discovery
https://www.readbyqxmd.com/read/27711255/scaffold-role-of-dusp22-in-ask1-mkk7-jnk-signaling-pathway
#13
Anna Ju, Young-Chang Cho, Ba Reum Kim, Sung Goo Park, Jeong-Hoon Kim, Kwonseop Kim, Jaehwi Lee, Byoung Chul Park, Sayeon Cho
Mitogen-activated protein kinases (MAPKs) are involved in a variety of intracellular events such as gene expression, cell proliferation, and programmed cell death. MAPKs are activated by dual phosphorylation on threonine and tyrosine residues through sequential activation of protein kinases. Recent studies have shown that the protein kinases involved in MAPK signal transductions might be organized into signaling complexes by scaffold proteins. These scaffold proteins are essential regulators that function by assembling the relevant molecular components in mammalian cells...
2016: PloS One
https://www.readbyqxmd.com/read/27693599/pleiotropic-properties-of-ask1
#14
REVIEW
Chihiro Sakauchi, Hiroaki Wakatsuki, Hidenori Ichijo, Kazuki Hattori
BACKGROUND: Apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), has the potential to induce cellular apoptosis under various physiological conditions. It has long been suggested that ASK1 is highly sensitive to oxidative stress and contributes substantially to apoptosis. However, recent studies have indicated that ASK1 has pleiotropic roles in living organisms through other mechanisms in addition to apoptosis. SCOPE OF THE REVIEW: This review describes the physiological functions of ASK1 in living organisms, focusing on the regulatory mechanisms of ASK1 activity and its importance in the pathogenesis of various diseases...
September 30, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27642277/blockade-of-apoptosis-signal-regulating-kinase-1-attenuates-matrix-metalloproteinase-9-activity-in-brain-endothelial-cells-and-the-subsequent-apoptosis-in-neurons-after-ischemic-injury
#15
So Y Cheon, Kyoung J Cho, So Y Kim, Eun H Kam, Jong E Lee, Bon-Nyeo Koo
Conditions of increased oxidative stress including cerebral ischemia can lead to blood-brain barrier dysfunction via matrix metalloproteinase (MMP). It is known that MMP-9 in particular is released from brain endothelial cells is involved in the neuronal cell death that occurs after cerebral ischemia. In the intracellular signaling network, apoptosis signal-regulating kinase 1 (ASK1) is the main activator of the oxidative stress that is part of the pathogenesis of cerebral ischemia. ASK1 also promotes apoptotic cell death and brain infarction after ischemia and is associated with vascular permeability and the formation of brain edema...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27631783/klhdc10-deficiency-protects-mice-against-tnf%C3%AE-induced-systemic-inflammation
#16
Namiko Yamaguchi, Shiori Sekine, Isao Naguro, Yusuke Sekine, Hidenori Ichijo
Systemic inflammatory response syndrome (SIRS) is a form of fatal acute inflammation for which there is no effective treatment. Here, we revealed that the ablation of Kelch domain containing 10 (KLHDC10), which we had originally identified as an activator of Apoptosis Signal-regulating Kinase 1 (ASK1), protects mice against TNFα-induced SIRS. The disease development of SIRS is mainly divided into two stages. The early stage is characterized by TNFα-induced systemic necroptosis, a regulated form of necrosis mediated by Receptor-interacting protein (RIP) 1/3 kinases...
2016: PloS One
https://www.readbyqxmd.com/read/27615513/dock3-nmda-receptor-interaction-as-a-target-for-glaucoma-therapy
#17
Atsuko Kimura, Kazuhiko Namekata, Xiaoli Guo, Chikako Harada, Takayuki Harada
Glaucoma is a neurodegenerative disease of the eye and it is one of the major causes of blindness. Glaucoma is usually associated with elevated intraocular pressure (IOP) and the current therapy focuses on reduction of IOP. However, neuroprotective strategies could also be beneficial for treatment of glaucoma because the pathology of the disease involves retinal ganglion cell (RGC) death and damage to the optic nerve. Dedicator of cytokinesis 3 (Dock3) is an atypical guanine exchange factor (GEF) that belongs to a family of Dock proteins, Dock1-11...
September 9, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27600583/oxidative-stress-impairs-the-stimulatory-effect-of-s100-proteins-on-protein-phosphatase-5-activity
#18
Fuminori Yamaguchi, Mitsumasa Tsuchiya, Seiko Shimamoto, Tomohito Fujimoto, Hiroshi Tokumitsu, Masaaki Tokuda, Ryoji Kobayashi
Oxidative stress is the consequence of an imbalance between the production of harmful reactive oxygen species and the cellular antioxidant system for neutralization, and it activates multiple intracellular signaling pathways, including apoptosis signal-regulating kinase 1 (ASK1). Protein phosphatase 5 (PP5) is a serine/threonine phosphatase involved in oxidative stress responses. Previously, we reported that S100 proteins activate PP5 in a calcium-dependent manner. S100 proteins belong to a family of small EF-hand calcium-binding proteins involved in many processes such as cell proliferation, differentiation, apoptosis, and inflammation...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27588831/cysteine-residues-mediate-high-affinity-binding-of-thioredoxin-to-ask1
#19
Salome Kylarova, Dalibor Kosek, Olivia Petrvalska, Katarina Psenakova, Petr Man, Jaroslav Vecer, Petr Herman, Veronika Obsilova, Tomas Obsil
Apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) activates p38 mitogen-activated protein kinase and the c-Jun N-terminal kinase in response to proinflammatory and stress signals. In non-stress conditions, ASK1 is inhibited by association with thioredoxin (TRX) which binds to the TRX-binding domain (ASK1-TBD) at the N-terminus of ASK1. TRX dissociates in response to oxidative stress allowing the ASK1 activation. However, the molecular basis for the ASK1:TRX1 complex dissociation is still not fully understood...
September 2, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27514745/structural-insight-into-the-14-3-3-protein-dependent-inhibition-of-protein-kinase-ask1-apoptosis-signal-regulating-kinase-1
#20
Olivia Petrvalska, Dalibor Kosek, Zdenek Kukacka, Zdenek Tosner, Petr Man, Jaroslav Vecer, Petr Herman, Veronika Obsilova, Tomas Obsil
Apoptosis signal-regulating kinase 1 (ASK1, also known as MAP3K5), a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, regulates diverse physiological processes. The activity of ASK1 is triggered by various stress stimuli and is involved in the pathogenesis of cancer, neurodegeneration, inflammation, and diabetes. ASK1 forms a high molecular mass complex whose activity is, under non-stress conditions, suppressed through interaction with thioredoxin and the scaffolding protein 14-3-3...
September 23, 2016: Journal of Biological Chemistry
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