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https://www.readbyqxmd.com/read/29743976/cell-type-specific-mechanisms-in-the-pathogenesis-of-ischemic-stroke-the-role-of-apoptosis-signal-regulating-kinase-1
#1
REVIEW
So Yeong Cheon, Eun Jung Kim, Jeong Min Kim, Bon-Nyeo Koo
Stroke has become a more common disease worldwide. Despite great efforts to develop treatment, little is known about ischemic stroke. Cerebral ischemia activates multiple cascades of cell type-specific pathomechanisms. Ischemic brain injury consists of a complex series of cellular reactions in various cell types within the central nervous system (CNS) including platelets, endothelial cells, astrocytes, neutrophils, microglia/macrophages, and neurons. Diverse cellular changes after ischemic injury are likely to induce cell death and tissue damage in the brain...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29742502/sulfotanshinone-iia-sodium-ameliorates-glucose-peritoneal-dialysis-solution-induced-human-peritoneal-mesothelial-cell-injury-via-suppression-of-ask1-p38-mediated-oxidative-stress
#2
Yao Zhou, Weiming He, Wei Sun, Zhanwei Zhou, Minjie Sun, Ping Xia, Wei Li, Min Zheng, Lu Zhang, Jie Ni, Kun Gao
BACKGROUND/AIMS: Long-term use of high-glucose peritoneal dialysis solution (PDS) induces peritoneal mesothelial cell (PMC) injury, peritoneal dysfunction, and peritoneal dialysis (PD) failure in patients with end-stage renal disease. How to preserve PMCs in PD is a major challenge for nephrologists worldwide. In this study, we aimed to elucidate the efficacy and mechanisms of sulfotanshinone IIA sodium (Tan IIa) in ameliorating high-glucose PDS-induced human PMC injury. METHODS: The human PMC line HMrSV5 was incubated with 4...
May 4, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29732320/activation-of-host-ire1%C3%AE-dependent-signaling-axis-contributes-the-intracellular-parasitism-of-brucella-melitensis
#3
Aseem Pandey, Furong Lin, Ana L Cabello, Luciana F da Costa, Xuehuan Feng, Hui-Qiang Feng, Ming-Zhe Zhang, Takao Iwawaki, Allison Rice-Ficht, Thomas A Ficht, Paul de Figueiredo, Qing-Ming Qin
Brucella spp. are intracellular vacuolar pathogens that causes brucellosis, a worldwide zoonosis of profound importance. We previously demonstrated that the activity of host unfolded protein response (UPR) sensor IRE1α (inositol-requiring enzyme 1) and ER-associated autophagy confer susceptibility to Brucella melitensis and Brucella abortus intracellular replication. However, the mechanism by which host IRE1α regulates the pathogen intracellular lifestyle remains elusive. In this study, by employing a diverse array of molecular approaches, including biochemical analyses, fluorescence microscopy imaging, and infection assays using primary cells derived from Ern1 (encoding IRE1) conditional knockout mice, we address this gap in our understanding by demonstrating that a novel IRE1α to ULK1, an important component for autophagy initiation, signaling axis confers susceptibility to Brucella intracellular parasitism...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29729191/caspase-recruitment-domain-protein-6-protects-against-hepatic-steatosis-and-insulin-resistance-by-suppressing-ask1
#4
Peng Sun, Qiang Zeng, Daqing Cheng, Kuo Zhang, Jilin Zheng, Yupeng Liu, Yu-Feng Yuan, Yi-Da Tang
The rapidly increasing prevalence of metabolic disorders associated with non-alcoholic fatty liver disease (NAFLD) warrants further study of the underlying mechanism to identify key regulators as targets for the development of therapeutic interventions. Caspase recruitment domain protein 6 (Card6), as a member of the CARD family that regulates cell death and immunity, may potentially control this process. Indeed, Card6 downregulation was found to be closely associated with the fatty livers observed in NAFLD patients, obese mice and a palmitate-treated hepatocyte model...
May 5, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29707240/dual-function-of-peroxiredoxin-i-in-lipopolysaccharide-induced-osteoblast-apoptosis-via-reactive-oxygen-species-and-the-apoptosis-signal-regulating-kinase-1-signaling-pathway
#5
Hao Feng, Ziyu Li, Juan Du, Jing Sun, Wei Feng, Dongfang Li, Shanshan Liu, Wei Wang, Hongrui Liu, Norio Amizuka, Minqi Li
Lipopolysaccharide (LPS)-induced osteoblast apoptosis is a prominent factor to the defect in periodontal tissue repair in periodontal disease. LPS challenge contributes to the production of reactive oxygen species (ROS) in periodontitis, and peroxiredoxin 1 (Prx1) is an antioxidant protein that protect cells against oxidative damage from ROS. Without LPS stimulation, apoptotic rates were higher in both Prx1 knockout (Prx1KO ) and Prx1 overexpression (Prx1OE ) cells compared with wild type. After LPS stimulation, intracellular ROS in Prx1KO cells showed the highest level and Prx1OE cells showed the least...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29700281/smad-proteins-differentially-regulate-obesity-induced-glucose-and-lipid-abnormalities-and-inflammation-via-class-specific-control-of-ampk-related-kinase-mpk38-melk-activity
#6
Hyun-A Seong, Ravi Manoharan, Hyunjung Ha
Smad proteins have been implicated in metabolic processes, but little is known about how they regulate metabolism. Because Smad 2, 3, 4, and 7 have previously been shown to interact with murine protein serine-threonine kinase 38 (MPK38), an AMP-activated protein kinase (AMPK)-related kinase that has been implicated in obesity-associated metabolic defects, we investigated whether Smad proteins regulate metabolic processes via MPK38. Smads2/3/4 increased, but Smad7 decreased, MPK38-mediated apoptosis signal-regulating kinase-1 (ASK1)/transforming growth factor-β (TGF-β)/p53 signaling...
April 27, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29679557/acetaminophen-induced-liver-injury-is-attenuated-in-transgenic-fat-1-mice-endogenously-synthesizing-long-chain-n-3-fatty-acids
#7
Ruibing Feng, Yang Wang, Conghui Liu, Chunyan Yan, Hang Zhang, Huanxing Su, Jing X Kang, Chang-Zhen Shang, Jian-Bo Wan
Acetaminophen (APAP) overdose-induced hepatotoxicity is the most commonly cause of drug-induced liver failure characterized by oxidative stress, mitochondrial dysfunction, and cell damage. Therapeutic efficacy of omega-3 polyunsaturated fatty acids (n-3 PUFA) in several models of liver disease is well documented. However, the impacts of n-3 PUFA on APAP hepatotoxicity are not adequately addressed. In this study, the fat-1 transgenic mice that synthesize endogenous n-3 PUFA and wild type (WT) littermates were injected intraperitoneally with APAP at the dose of 400 mg/kg to induce liver injury, and euthanized at 0 h, 2 h, 4 h and 6 h post APAP injection for sampling...
April 18, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29677535/betulinic-acid-attenuates-dexamethasone-induced-oxidative-damage-through-the-jnk-p38-mapk-signaling-pathway-in-mice
#8
Lijuan Zhu, Xianglian Yi, Jing Zhao, Zhihang Yuan, Lixin Wen, Blazej Pozniak, Bozena Obminska-Mrukowicz, Yanan Tian, Zhuliang Tan, Jing Wu, Jine Yi
Dexamethasone (Dex), a potent anti-inflammatory/immunosuppressive agent, has been shown to induce oxidative stress. Betulinic acid (BA) is a pentacyclic lupane triterpene with a potent antioxidant activity. The aim of this study was to investigate the ameliorative effect and underlying mechanisms of BA on Dex-induced oxidative damage. Mice were pretreated with BA orally (0, 0.25, 0.5, and 1.0 mg/kg) daily for 14 days, and then a single dose of Dex (25 mg/kg body weight) was administered intraperitoneally 8 h after the last administration of BA to induce oxidative stress...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29665822/toxoplasma-gondii-dense-granule-protein-15-induces-apoptosis-in-choriocarcinoma-jeg-3-cells-through-endoplasmic-reticulum-stress
#9
Wei Wei, Fangfang Zhang, He Chen, Yuanyuan Tang, Tian Xing, Qingli Luo, Li Yu, Jian Du, Jilong Shen, Linjie Zhang
BACKGROUND: Toxoplasma gondii, a single-celled parasite commonly found in mammals, has been shown to induce trophoblast cell apoptosis and subsequently cause fetal damage and abortion. Although dense granule protein 15 (GRA15) has been identified as a key component in innate immunity to T. gondii infection and its pathogenesis, its role in host cell apoptosis remains unclarified. METHODS: Type II GRA15 (GRA15II ) cDNA was inserted into a plasmid encoding enhanced green fluorescent protein (pEGFP)...
April 17, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29657313/curcumin-attenuates-inflammation-in-a-severe-acute-pancreatitis-animal-model-by-regulating-traf1-ask1-signaling
#10
Shuo Yu, Min Wang, Xingjun Guo, Renyi Qin
BACKGROUND Inflammation plays an important role in initiation and development of severe acute pancreatitis (SAP). Curcumin exerts potent anti-inflammatory effects in many diseases, including acute pancreatitis. However, the specific molecular mechanisms are not clear. MATERIAL AND METHODS Intra-biliopancreatic duct injection of taurocholate was used to establish an animal model of SAP. Curcumin was administrated to animals as pre-treatments. Concentrations of cytokines in serum and ascites were measured by enzyme-linked immunosorbent assay (ELISA)...
April 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29629899/ask1-2-signaling-promotes-inflammation-in-a-mouse-model-of-neutrophilic-dermatosis
#11
Sarang Tartey, Prajwal Gurung, Tejasvi Krishna Dasari, Amanda Burton, Thirumala-Devi Kanneganti
Mice homozygous for the Tyr208Asn amino acid substitution in the carboxy terminus of Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1) (referred to as Ptpn6spin mice) spontaneously develop a severe inflammatory disease resembling neutrophilic dermatosis in humans. Disease in Ptpn6spin mice is characterized by persistent footpad swelling and suppurative inflammation. Recently, in addition to IL-1α and IL-1R signaling, we demonstrated a pivotal role for several kinases such as SYK, RIPK1, and TAK1 in promoting inflammatory disease in Ptpn6spin mice...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29627323/apoptosis-signal-regulating-kinase-1-and-nadph-oxidase-mediate-human-amylin-evoked-redox-stress-and-apoptosis-in-pancreatic-beta-cells
#12
Sanghamitra Singh, Diti Chatterjee Bhowmick, Satyabrata Pany, Myungkuk Joe, Noor Zaghlula, Aleksandar M Jeremic
Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). Studies show that hA accumulation is stressful to β-cells and that misfolding of human amylin evokes redox stress and activates mitogen activated protein (MAP) kinases, p38 MAPK and c-Jun N-terminal (JNK) kinase. However, the molecular link and causality between hA-evoked redox stress, NOX activity and MAP kinases signaling in pancreatic β-cells is incompletely understood...
April 5, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29625389/high-molecular-weight-hyaluronan-attenuates-fine-particulate-matter-induced-acute-lung-injury-through-inhibition-of-ros-ask1-p38-jnk-mediated-epithelial-apoptosis
#13
Chenming Xu, Qiwen Shi, Leifang Zhang, Hang Zhao
Inhalation of fine particulate matter (PM2.5 ) is asscoiated with lung injury. High molecular weight hyaluronan (HMW-HA) is an essential constituent of extracellular matrix (ECM), exhibiting anti-oxidative and anti-inflammatory properties when administered by injection, inhalation, nebulization or gene delivery of HA synthases. The aim of the present study is to determine whether HMW-HA alleviates PM2.5 -induced acute lung injury (ALI) and investigate the underlying mechanisms. We observed that HMW-HA suppressed pathological injury, inflammation, oxidative stress, edema and epithelial damage caused by PM2...
March 30, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29600430/targeting-incretin-hormones-and-the-ask-1-pathway-as-therapeutic-options-in-the-treatment-of-non-alcoholic-steatohepatitis
#14
REVIEW
Alexander J Kovalic, Sanjaya K Satapathy, Naga Chalasani
Non-alcoholic fatty liver disease (NAFLD) is currently one of the leading forms of chronic liver disease, and its rising frequency worldwide has reached epidemic proportions. NAFLD, particularly its progressive variant NASH (non-alcoholic steatohepatitis), can lead to advanced fibrosis, cirrhosis, and HCC. The pathophysiologic mechanisms that contribute to the development and progression of NAFLD and NASH are complex, and as such myriad therapies are under investigation targeting different pathophysiological mechanisms...
March 29, 2018: Hepatology International
https://www.readbyqxmd.com/read/29599892/thioredoxin-1-protects-bone-marrow-derived-mesenchymal-stromal-cells-from-hyperoxia-induced-injury-in-vitro
#15
Lei Zhang, Jin Wang, Yan Chen, Lingkong Zeng, Qiong Li, Yalan Liu, Lin Wang
Background: The poor survival rate of mesenchymal stromal cells (MSC) transplanted into recipient lungs greatly limits their therapeutic efficacy for diseases like bronchopulmonary dysplasia (BPD). The aim of this study is to evaluate the effect of thioredoxin-1 (Trx-1) overexpression on improving the potential for bone marrow-derived mesenchymal stromal cells (BMSCs) to confer resistance against hyperoxia-induced cell injury. Methods: 80% O2 was used to imitate the microenvironment surrounding-transplanted cells in the hyperoxia-induced lung injury in vitro ...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29592844/anti-oxidative-and-anti-apoptotic-effects-of-acupuncture-role-of-thioredoxin-1-in-the-hippocampus-of-vascular-dementia-rats
#16
Wen Zhu, Xue-Rui Wang, Si-Qi Du, Chao-Qun Yan, Na-Na Yang, Lu-Lu Lin, Guang-Xia Shi, Cun-Zhi Liu
Emerging evidence suggests that acupuncture treatment has anti-oxidative effects that effects cognitive impairment in vascular dementia (VD) rats. In the present study, we aimed to investigate whether thioredoxin-1 (Trx-1)/thioredoxin reductase-1 (TrxR-1) were involved in the beneficial effects of acupuncture. After 2-weeks of acupuncture treatment, Morris water maze (MWM), dihydroethidium (DHE) staining, Nissl staining and TdT-mediated dUTP nick end labeling (TUNEL) staining were used to assess the effects of acupuncture on cognitive function and hippocampal neuronal injury in two-vessel occlusion (2VO) model...
March 25, 2018: Neuroscience
https://www.readbyqxmd.com/read/29590425/mir-106a-increases-granulosa-cell-viability-and-is-down-regulated-in-women-with-diminished-ovarian-reserve
#17
Liming Hong, Sha Peng, Ying Li, Ying Fang, Qin Wang, Christian Klausen, Chenghong Yin, Shuyu Wang, Peter C K Leung, Xiaokui Yang
Context: Women with diminished ovarian reserve (DOR) suffer from reduced fertility, cardiovascular events and osteoporosis. Though differential microRNA (miRNA) expression has been described in several ovarian disorders, little is known about the role of miRNAs in the pathogenesis of DOR. Objective: Identify differentially expressed miRNAs in DOR and explore the role of miR-106a in human granulosa cell proliferation. Design: MiRNA microarray (n=3) and RT-qPCR (n=30) were used to examine miRNA expression in serum and granulosa cells from normal cycling and DOR women...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29568962/dickkopf%C3%A2-3-upregulation-mediates-the-cardioprotective-effects-of-curcumin-on-chronic-heart-failure
#18
Quan Cao, Junxia Zhang, Ling Gao, Yijie Zhang, Mingyan Dai, Mingwei Bao
Curcumin, isolated from rhizome of turmeric, has been widely studied as a potential therapeutic drug for cancer. However, protective effects of curcumin on chronic heart failure (CHF) have not been fully studied. In the present study, the effects of curcumin on CHF and the underlying mechanisms were investigated. A total of 40 rabbits were randomized into 4 groups: Control rabbits fed with placebo (Con) or curcumin (Con‑cur), CHF rabbits fed with placebo (CHF) or curcumin (CHF‑cur). CHF was induced by volume and pressure overload...
March 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29566310/dc-cik-cells-derived-from-ovarian-cancer-patient-menstrual-blood-activate-the-tnfr1-ask1-aip1-pathway-to-kill-autologous-ovarian-cancer-stem-cells
#19
Wenxing Qin, Ying Xiong, Juan Chen, Yongyi Huang, Te Liu
Ovarian cancer stem cells (OCSCs) are highly carcinogenic and have very strong resistance to traditional chemotherapeutic drugs; therefore, they are an important factor in ovarian cancer metastasis and recurrence. It has been reported that dendritic cell (DC)-cytokine-induced killer (CIK) cells have significant killing effects on all cancer cells across many systems including the blood, digestive, respiratory, urinary and reproductive systems. However, whether DC-CIK cells can selectively kill OCSCs is currently unclear...
March 22, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29555767/ask-family-kinases-mediate-cellular-stress-and-redox-signaling-to-circadian-clock
#20
Kiyomichi Imamura, Hikari Yoshitane, Kazuki Hattori, Mitsuo Yamaguchi, Kento Yoshida, Takenori Okubo, Isao Naguro, Hidenori Ichijo, Yoshitaka Fukada
Daily rhythms of behaviors and physiologies are generated by the circadian clock, which is composed of clock genes and the encoded proteins forming transcriptional/translational feedback loops (TTFLs). The circadian clock is a self-sustained oscillator and flexibly responds to various time cues to synchronize with environmental 24-h cycles. However, the key molecule that transmits cellular stress to the circadian clockwork is unknown. Here we identified apoptosis signal-regulating kinase (ASK), a member of the MAPKKK family, as an essential mediator determining the circadian period and phase of cultured cells in response to osmotic changes of the medium...
April 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
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