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Bioflavonoid

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https://www.readbyqxmd.com/read/27889148/surface-attachment-of-active-antimicrobial-coatings-onto-conventional-plastic-based-laminates-and-performance-assessment-of-these-materials-on-the-storage-life-of-vacuum-packaged-beef-sub-primals
#1
David Clarke, Andrey A Tyuftin, Malco C Cruz-Romero, Declan Bolton, Seamus Fanning, Shashi K Pankaj, Carmen Bueno-Ferrer, Patrick J Cullen, Joe P Kerry
Two antimicrobial coatings, namely Sodium octanoate and Auranta FV (a commercial antimicrobial composed of bioflavonoids, citric, malic, lactic, and caprylic acids) were used. These two antimicrobials were surface coated onto the inner polyethylene layer of cold plasma treated polyamide films using beef gelatin as a carrier and coating polymer. This packaging material was then used to vacuum pack beef sub-primal cuts and stored at 4 °C. A control was prepared using the non-coated commercial laminate and the same vacuum packaged sub-primal beef cuts...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27864057/inhibitory-effects-of-the-dietary-flavonoid-quercetin-on-the-enzyme-activity-of-zinc-ii-dependent-yeast-alcohol-dehydrogenase-spectroscopic-and-molecular-docking-studies
#2
Sutanwi Bhuiya, Lucy Haque, Ankur Bikash Pradhan, Suman Das
A multispectroscopic exploration was employed to investigate the interaction between the metallo-enzyme alcohol dehydrogenase (ADH) from yeast with bioflavonoid quercetin (QTN). Here, we have characterized the complex formation between QTN and Zn(2+) in aqueous solution and then examined the effect of such complex formation on the enzymatic activity of a zinc(II)-dependent enzyme alcohol dehydrogenase from yeast. We have observed an inhibition of enzymatic activity of ADH in presence of QTN. Enzyme inhibition kinetic experiments revealed QTN as a non-competitive inhibitor of yeast ADH...
November 15, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27853388/efficacy-tolerability-and-safety-of-an-oral-enzyme-combination-vs-diclofenac-in-osteoarthritis-of-the-knee-results-of-an-individual-patient-level-pooled-reanalysis-of-data-from-six-randomized-controlled-trials
#3
Michael A Ueberall, Gerhard Hh Mueller-Schwefe, Rainer Wigand, Ute Essner
OBJECTIVE: To compare efficacy, safety, and tolerability of an oral enzyme combination (OEC) containing proteolytic enzymes and bioflavonoid vs diclofenac (DIC), a nonselective nonsteroidal anti-inflammatory drug in the treatment of osteoarthritis of the knee. MATERIALS AND METHODS: This was an individual patient-level pooled reanalysis of patient-reported data from prospective, randomized, double-blind, parallel-group studies in adult patients with moderate-to-severe osteoarthritis of the knee treated for at least 3 weeks with OEC or DIC...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27836465/naringin-regulates-glutamate-nitric-oxide-cgmp-pathway-in-ammonium-chloride-induced-neurotoxicity
#4
Arumugam Ramakrishnan, Natesan Vijayakumar, Mani Renuka
Naringin, plant bioflavonoid extracted mainly from grapefruit and other related citrus species. This study was designed to assess the neuroprotective effect of naringin on ammonium chloride (NH4Cl) induced hyperammonemic rats. Experimental hyperammonemia was induced by intraperitonial injection (i.p) of NH4Cl (100mg/kg body weight (b.w.)) thrice a week for 8 consecutive weeks. Hyperammonemic rats were treated with naringin (80mg/kg b.w.) via oral gavage. Naringin administration drastically restored the levels of blood ammonia, plasma urea, nitric oxide (NO), glutamate, glutamine, lipid peroxidation, lipid profile, activities of liver marker enzymes, antioxidant status and sodium/potassium-ATPase (Na(+)/K(+)-ATPase)...
November 8, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27823559/biological-and-chemical-aspects-of-natural-biflavonoids-from-plants-a-brief-review
#5
Vanessa Silva Gontijo, Marcelo Henrique Dos Santos, Claudio Viegas
Biflavonoids belong to a subclass of the plant flavonoids family and are limited to several species in the plant kingdom. In the literature, biflavonoids are extensively reported for their pharmacological properties including anti-inflammatory, antioxidant, inhibitory activity against phospholipase A2 (PLA2) and antiprotozoal activity. These activities have been discovered from the small number of biflavonoid structures that have been investigated, although the natural biflavonoids library is likely to be large...
November 4, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27812412/in-silico-study-on-anti-chikungunya-virus-activity-of-hesperetin
#6
Adrian Oo, Pouya Hassandarvish, Sek Peng Chin, Vannajan Sanghiran Lee, Sazaly Abu Bakar, Keivan Zandi
BACKGROUND: The re-emerging, Aedes spp. transmitted Chikungunya virus (CHIKV) has recently caused large outbreaks in a wide geographical distribution of the world including countries in Europe and America. Though fatalities associated with this self-remitting disease were rarely reported, quality of patients' lives have been severely diminished by polyarthralgia recurrence. Neither effective antiviral treatment nor vaccines are available for CHIKV. Our previous in vitro screening showed that hesperetin, a bioflavonoid exhibits inhibitory effect on the virus intracellular replication...
2016: PeerJ
https://www.readbyqxmd.com/read/27761071/inhibitory-and-cytotoxic-activities-of-chrysin-on-human-breast-adenocarcinoma-cells-by-induction-of-apoptosis
#7
Saeed Samarghandian, Mohsen Azimi-Nezhad, Abasalt Borji, Malihe Hasanzadeh, Farahzad Jabbari, Tahereh Farkhondeh, Mohammad Samini
OBJECTIVES: Chrysin, an active natural bioflavonoid found in honey and many plant extracts, was first known for its antioxidant and anti-inflammatory effects. The fact that antioxidants have several inhibitory effects against different diseases, such as cancer, led to search for food rich in antioxidants. In this study, we investigated the antiproliferative and apoptotic effects of chrysin on the cultured human breast cancer cells (MCF-7). MATERIALS AND METHODS: Cells were cultured in Roswell Park Memorial Institute medium and treated with different chrysin concentrations for three consecutive days...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27710596/the-effect-of-quercetin-on-inflammatory-factors-and-clinical-symptoms-in-women-with-rheumatoid-arthritis-a-double-blind-randomized-controlled-trial
#8
Fatemeh Javadi, Arman Ahmadzadeh, Shahryar Eghtesadi, Naheed Aryaeian, Mozhdeh Zabihiyeganeh, Abbas Rahimi Foroushani, Shima Jazayeri
OBJECTIVE: Previous studies have shown that the bioflavonoid quercetin has anti-inflammatory and anti-nociceptive effects. We investigated the effect of quercetin supplementation on inflammation, disease severity, and clinical symptoms in women with rheumatoid arthritis (RA). METHODS: The present study was a randomized, double-blind, placebo-controlled clinical trial in which 50 women with RA were allocated into a quercetin (500 mg/day) or placebo group for 8 weeks...
October 6, 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27694007/morin-inhibits-cell-proliferation-and-fibronectin-accumulation-in-rat-glomerular-mesangial-cells-cultured-under-high-glucose-condition
#9
Ya-Qiong Ke, Chao Liu, Jian-Bo Hao, Ling Lu, Nan-Nan Lu, Zhao-Ke Wu, Shen-Shen Zhu, Xi-Ling Chen
Morin, is a natural bioflavonoid isolated from Chinese herbs of the Moraceae family, has been reported to possess antidiabetic activity. However, the role of morin on glomerular mesangial cells (MCs) proliferation and extracellular matrix (ECM) accumulation in diabetic condition is still unclear. Therefore, in this study, we investigated the role of morin on cell proliferation and ECM accumulation in rat glomerular MCs cultured under high glucose (HG) condition. Our results showed that morin inhibited HG-induced MC proliferation, arrested HG-induced cell-cycle progression, reversed HG-inhibited expression of p21(Waf1/Cip1) and p27(Kip1)...
September 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27693741/apigenin-protects-mice-from-pneumococcal-pneumonia-by-inhibiting-the-cytolytic-activity-of-pneumolysin
#10
Meng Song, Li Li, Meng Li, Yonghong Cha, Xuming Deng, Jianfeng Wang
Streptococcus pneumoniae is an important human pathogenic bacterium that can cause various life-threatening infections. Pneumolysin (PLY), the pore-forming toxin that forms large pores in the cell membrane, is a key virulence factor secreted by S. pneumoniae that penetrates the physical defenses of the host and plays an important role in the pathogenesis of pneumococcal diseases, such as pneumonia, meningitis, bacteremia and otitis media. This study showed that apigenin, one of the bioflavonoids widely found in herbs, inhibits PLY-induced hemolysis by inhibiting the oligomerization of PLY and has no anti-S...
September 28, 2016: Fitoterapia
https://www.readbyqxmd.com/read/27690015/gspe-inhibits-hmgb1-release-attenuating-renal-ir-induced-acute-renal-injury-and-chronic-renal-fibrosis
#11
Juan Zhan, Kun Wang, Conghui Zhang, Chunxiu Zhang, Yueqiang Li, Ying Zhang, Xiaoyan Chang, Qiaodan Zhou, Ying Yao, Yanyan Liu, Gang Xu
Grape seed proanthocyanindin extract (GSPE) is a polyphenolic bioflavonoid derived from grape seeds and has been widely studied for its potent antioxidant, anti-inflammatory and antitumor activities. HMGB1 is a newly discovered danger-associated molecular pattern (DAMP) that has potent proinflammatory effects once released by necrotic cells. However, the effect of GSPE on the HMGB1, and the relationship of those two with acute kidney injury and chronic kidney fibrosis are unknown. This study aimed to investigate the impact of GSPE on acute kidney injury and chronic fibrosis...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27652191/natural-flavonoids-silymarin-and-quercetin-improve-the-brain-distribution-of-co-administered-p-gp-substrate-drugs
#12
D Ravikumar Reddy, Amit Khurana, Swarna Bale, Ramu Ravirala, V Samba Siva Reddy, M Mohankumar, Chandraiah Godugu
P-glycoprotein (P-gp), a well known efflux transporter in the blood brain barrier inhibits the uptake of substrate drugs into brain. The main aim of this study is to evaluate the effect of natural product based P-gp inhibitors on brain penetration of various CNS drugs which are P-gp substrates. In this study, we have evaluated the inhibitory effects of natural bioflavonoids (quercetin and silymarin) on P-gp by using digoxin and quinidine as model P-gp model substrate drugs. In vitro inhibitory effects were evaluated in Caco-2 cell lines using digoxin as a model drug and in vivo P-gp inhibiting effect was evaluated in mice model using quinidine as model drug...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27626494/quercetin-ameliorates-a%C3%AE-toxicity-in-drosophila-ad-model-by-modulating-cell-cycle-related-protein-expression
#13
Yan Kong, Ke Li, Tingting Fu, Chao Wan, Dongdong Zhang, Hang Song, Yao Zhang, Na Liu, Zhenji Gan, Liudi Yuan
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by β amyloid (Aβ) deposition and neurofibril tangles. It has been reported that a bioflavonoid, quercetin, could ameliorate AD phenotypes in C. elegans and mice. However, the mechanism underlying the ameliorative effect of quercetin is not fully understood yet. Drosophila models could recapitulate AD-like phenotypes, such as shortened lifespan, impaired locomotive ability as well as defects in learning and memory. So in this study, we investigated the effects of quercetin on AD in Drosophila model and explored the underlying mechanisms...
September 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27626051/3d-qsar-modelling-dataset-of-bioflavonoids-for-predicting-the-potential-modulatory-effect-on-p-glycoprotein-activity
#14
Pathomwat Wongrattanakamon, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Supat Jiranusornkul
The data is obtained from exploring the modulatory activities of bioflavonoids on P-glycoprotein function by ligand-based approaches. Multivariate Linear-QSAR models for predicting the induced/inhibitory activities of the flavonoids were created. Molecular descriptors were initially used as independent variables and a dependent variable was expressed as pFAR. The variables were then used in MLR analysis by stepwise regression calculation to build the linear QSAR data. The entire dataset consisted of 23 bioflavonoids was used as a training set...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27620077/concomitant-reduction-of-c-myc-expression-and-pi3k-akt-mtor-signaling-by-quercetin-induces-a-strong-cytotoxic-effect-against-burkitt-s-lymphoma
#15
Marisa Granato, Celeste Rizzello, Maria Anele Romeo, Shivangi Yadav, Roberta Santarelli, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone
Burkitt's lymphoma is an aggressive B cell lymphoma whose pathogenesis involves mainly c-Myc translocation and hyperexpression, in addition to antigen-independent BCR signaling and, in some cases, EBV infection. As result of BCR signaling activation, the PI3K/AKT/mTOR pathway results constitutively activated also in the absence of EBV, promoting cell survival and counterbalancing the pro-apoptotic function that c-Myc may also exert. In this study we found that quercetin, a bioflavonoid widely distributed in plant kingdom, reduced c-Myc expression and inhibited the PI3K/AKT/mTOR activity in BL, leading to an apoptotic cell death...
October 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27509965/induction-of-human-hepatocellular-carcinoma-hepg2-cell-apoptosis-by-naringin
#16
Ratana Banjerdpongchai, Benjawan Wudtiwai, Patompong Khawon
Naringin, a bioflavonoid found in Citrus seeds, inhibits proliferation of cancer cells. The objectives of this study were to investigate the mode and mechanism(s) of hepatocellular carcinoma HepG2 cell death induced by naringin. The cytotoxicity of naringin towards HepG2 cells proved dosedependent, measured by MTT assay. Naringintreated HepG2 cells underwent apoptosis also in a concentration related manner, determined by annexin Vfluorescein isothiocyanate (FITC) and propidium iodide (PI) employing flow cytometry...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27496028/antiproliferative-effects-of-modified-bioflavonoid-in-ex-vivo-model
#17
D Z Albegova, O V Kamkina, S I Pavlova, Zh K Albegova, O S Laptev, I G Kozlov
We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by their explantation and in vitro activation with T- and B-cell mitogens in cell culture. Intraperitoneal injection of modified bioflavonoid and quercetin dihydrate produced a dose-dependent inhibition of proliferation of the in vitroactivated splenocytes; modified bioflavonoid demonstrated higher antiproliferative activity...
July 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27488610/the-in-vivo-antineoplastic-and-therapeutic-efficacy-of-troxerutin-on-rat-preneoplastic-liver-biochemical-histological-and-cellular-aspects
#18
Nisha Susan Thomas, Kiran George, Sivaranjani Arivalagan, Vijay Mani, Aktarul Islam Siddique, Nalini Namasivayam
PURPOSE: Troxerutin (TXER), a trihydroxyethylated derivative of the natural bioflavonoid rutin, abundantly found in tea, various fruits and vegetables, is known to exhibit ample pharmacological properties. In the present investigation, we examined the antineoplastic, therapeutic efficacy and furthermore the possible mechanisms of action of TXER against NAFLD/NASH progression to hepatocarcinogenesis. METHODS: The effect of TXER (12.5, 25 or 50 mg/kg b.w/day) was evaluated on the nitrosodiethylamine (NDEA) model of hepatocarcinogenesis in rats, after 16 weeks of oral treatment, with special focus on liver specific enzymes, xenobiotic metabolizing enzymes, antioxidant status, lipid peroxidation profile, DNA damage, fibrosis, cell proliferation and inflammatory status...
August 3, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27435287/the-effects-of-astilbin-on-cognitive-impairments-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#19
Dongmei Wang, Sanqiang Li, Jing Chen, Ling Liu, Xiaoying Zhu
Bioflavonoids are being utilised as neuroprotectants in the treatment of various neurological disorders, including Alzheimer's disease (AD). Astilbin, a bioflavanoid, has been reported to have potent neuroprotective effects, but its preventive effects on amyloid-β (Aβ)-induced, Alzheimer's disease-related, cognitive impairment, and the underlying mechanisms of these effects have not been well characterised. Five-month-old APPswe/PS1dE9 transgenic mice were randomly assigned to a vehicle group and two astilbin (either 20 or 40 mg/kg per day, intraperitoneally) groups...
July 19, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27423764/gardenin-b-induced-cell-death-in-human-leukemia-cells-involves-multiple-caspases-but-is-independent-of-the-generation-of-reactive-oxygen-species
#20
Javier Cabrera, Ester Saavedra, Henoc Del Rosario, Juan Perdomo, Juan F Loro, Diego A Cifuente, Carlos E Tonn, Celina García, José Quintana, Francisco Estévez
Flavonoids have attracted great interest due to their possible anticancer activities. Here we investigated the antiproliferative activity of the flavonoids isolated from Baccharis scandens against human leukemia cell lines and found that the methoxyflavonoid gardenin B was the most cytotoxic compound against HL-60 and U-937 cells, showing IC50 values between 1.6 and 3.0 μM, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. These effects on viability were accompanied by the concentration- and time-dependent appearance of apoptosis as evidenced by DNA fragmentation, formation of apoptotic bodies and a sub-G1 ratio increase...
August 25, 2016: Chemico-biological Interactions
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