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Bioflavonoid

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https://www.readbyqxmd.com/read/29230268/an-alginate-cyclodextrin-spray-drying-matrix-to-improve-shelf-life-and-antioxidant-efficiency-of-a-blood-orange-by-product-extract-rich-in-polyphenols-mmps-inhibition-and-antiglycation-activity-in-dysmetabolic-diseases
#1
Maria Rosaria Lauro, Lucia Crascì, Virgilio Giannone, Gabriele Ballistreri, Simona Fabroni, Francesca Sansone, Paolo Rapisarda, Anna Maria Panico, Giovanni Puglisi
Alginate and β-cyclodextrin were used to produce easily dosable and spray-dried microsystems of a dried blood orange extract with antidysmetabolic properties, obtained from a by-product fluid extract. The spray-dried applied conditions were able to obtain a concentrate dried extract without the loss of AOA and with TPC and TMA values of 35-40% higher than that of the starting material. They were also effective in producing microparticles with 80-100% of encapsulation efficiency. The 2% sodium alginate was capable of improving the extract shelf life, while the beta-cyclodextrin (1 : 1 molar ratio with dried extract) prolonged the extract antioxidant efficiency by 6 hours...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29229355/effects-of-biflavonoids-from-garcinia-madruno-on-a-triple-transgenic-mouse-model-of-alzheimer-s-disease
#2
Angélica Maria Sabogal-Guáqueta, Luis Carrillo-Hormaza, Edison Osorio, Gloria Patricia Cardona-Gómez
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is pathologically characterized by the deposition of β-amyloid (βA) peptides in senile plaques and neurofibrillary tangles in the brain. Flavonoids have recently been used to prevent and treat a variety of neurodegenerative diseases, but little is known about bioflavonoids. In this study, we evaluate whether a biflavonoid fraction (BF) exerts neuroprotective effects on an aged triple transgenic mouse mode of AD (3xTg-AD). Then, 21-24-month-old 3xTg AD mice were i...
December 8, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29193444/morin-exerts-neuroprotection-via-attenuation-of-ros-induced-oxidative-damage-and-neuroinflammation-in-experimental-diabetic-neuropathy
#3
Pragna Bachewal, Chayanika Gundu, Veera Ganesh Yerra, Anil Kumar Kalvala, Aparna Areti, Ashutosh Kumar
Morin, a bioflavonoid with diverse pharmacological effects against various diseases; in most cases morin protective effects were attributed to its detoxifying effect against reactive oxygen species (ROS). Diabetic neuropathy (DN) is a chronic, debilitating neuronal pain associated with intense generation of free radicals and proinflammatory cytokine accumulation in peripheral neurons. We investigated the pharmacological effect of morin against metabolic excess mediated mitochondrial ROS generation and corresponding effect on Nrf2, NF-κB pathways in Streptozotocin (STZ)-induced diabetic rats and in high glucose insulted Mouse neuroblastoma cell line, Neuro 2A (N2A)...
November 28, 2017: BioFactors
https://www.readbyqxmd.com/read/29166540/statistical-optimization-of-an-rp-hplc-method-for-the-determination-of-selected-flavonoids-in-berry-juices-and-evaluation-of-their-antioxidant-activities
#4
Andrija Ciric, Milena Jelikic-Stankov, Milica Cvijovic, Predrag Djurdjevic
An isocratic RP-HPLC method for the separation and identification of selected flavonoids (quercetin, rutin, luteolin-7-O-glucoside, kaempferol, and kaempferol-3-O-glucoside) in commercial berries juices (blackcurrant, blueberry, red raspberry and cherry) was developed with the aid of central composite design and response surface methodology. The optimal separation conditions were a mobile phase of 85:15 (% v/v) water/acetonitrile, pH of 2.8 (adjusted with formic acid), flow rate 0.5 mL/min and column temperature of 35 °C...
November 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29137246/apigenin-sensitizes-bel-7402-adm-cells-to-doxorubicin-through-inhibiting-mir-101-nrf2-pathway
#5
Ai-Mei Gao, Xiao-Yu Zhang, Zun-Ping Ke
Chemo-resistance is one of the main obstacle in hepatocellular carcinoma therapy. Apigenin as a natural bioflavonoid has been exhibited anti-cancer properties in various malignant cancers. The aim of this study is to evaluate the potential chemo-sensitization effect of apigenin in doxorubicin-resistant hepatocellular carcinoma cell line BEL-7402/ADM and to investigate its possible mechanism. We found that apigenin significantly reversed doxorubicin sensitivity and induced caspase-dependent apoptosis in BEL-7402/ADM cells...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108086/anti-degenerative-effect-of-apigenin-luteolin-and-quercetin-on-human-keratinocyte-and-chondrocyte-cultures-sar-evaluation
#6
Lucia Crascì, Venera Cardile, Giusy Longhitano, Francesco Nanfitò, Annamaria Panico
Background Inflammation is a dynamic process that occur on vascularized tissue in response to different stimuli causing cell injury and tissue degeneration. Reactive oxygen and nitrogen species (ROS and RNS) and advanced glycation end products (AGEs) have a key mediatory role in the development and progression of degenerative tissue process. The bioflavonoids possess a broad-spectrum of pharmacological activities. Their capability is related to their chemical structure. Methods In this study we evaluated and compare antioxidant, anti-glycative and anti-degenerative actions of two flavones apigenin and luteolin and a flavonol quercetin, in function of their hydroxyl groups arrangement...
November 6, 2017: Drug Research
https://www.readbyqxmd.com/read/29091869/galangin-gg-combined-with-cisplatin-ddp-to-suppress-human-lung-cancer-by-inhibition-of-stat3-regulated-nf-%C3%AE%C2%BAb-and-bcl-2-bax-signaling-pathways
#7
Shuo Yu, Lian-Sheng Gong, Nian-Feng Li, Yi-Feng Pan, Lun Zhang
Lung cancer represents a significant problem for public health worldwide. Galangin (GG), a natural active compound 3, 5, 7-trihydroxyflavone, is a type of bioflavonoid, which is isolated from the Alpinia galangal root and suggested to induce apoptosis in various cancers. We investigated the ability of Galangin (GG) to attenuate the drug resistance of human lung cancer cells, resistant to treatment of cisplatin (DDP). DDP is a pyrimidine analog, widely used in cancer treatment. Galangin and DDP co-treatment resulted in a dose-dependent suppression of the cell proliferation...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29068268/structural-insights-into-the-binding-mode-of-flavonols-with-the-active-site-of-matrix-metalloproteinase-9-through-molecular-docking-and-molecular-dynamic-simulations-studies
#8
Dhinakararajan Pradiba, Murali Aarthy, Velu Shunmugapriya, Sanjeev Kumar Singh, Mani Vasanthi
Cartilage degradation in rheumatoid arthritis is mediated principally by the collagenases and gelatinases. Gelatinase B (also calledMatrix metalloproteinase 9-MMP-9),is a valid target molecule which is known to participate in cartilage degradation as well as angiogenesis associated with the disease and inhibition of its activity shall prevent cartilage damage and angiogenesis. The focus of this study is to investigate the possibilities of MMP-9 inhibition by flavonol class of bioflavonoids by studying their crucial binding interactions at the active site of MMP 9using molecular docking(Glide XP and QPLD) and further improvisation by post docking MM-GBSA and molecular dynamic (MD) simulations...
October 25, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29032208/chitosan-based-nano-formulation-enhanced-the-anticancer-efficacy-of-hesperetin
#9
Lizha Mary, Balaji Sadhasivam, Kanagaraj Palaniyandi, Thangavel Muthuswamy, Ilangovan Ramachandran, Anandhan Balakrishnan, Surajit Pathak, Shoba Narayan, Satish Ramalingam
Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. Hesperetin is a bioflavonoid from citrus fruits and its clinical use is restricted because of the poor water solubility. Folate receptor is over expressed in various cancer cells. In this regard, we have synthesized the Chitosan Folate Hesperetin nanoparticle (CFH) by covalently conjugating folic acid with chitosan molecules...
October 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29018874/flavocoxid-exerts-a-potent-antiviral-effect-against-hepatitis-b-virus
#10
Teresa Pollicino, Cristina Musolino, Natasha Irrera, Alessandra Bitto, Daniele Lombardo, Martina Timmoneri, Letteria Minutoli, Giovanni Raimondo, Giovanni Squadrito, Francesco Squadrito, Domenica Altavilla
INTRODUCTION: Flavocoxid is a proprietary blend of two flavonoids, baicalin and catechin, and recent evidence has shown that bioflavonoids may exert antiviral activities. The potential antiviral activity of Flavocoxid against hepatitis B virus (HBV) was evaluated. Additionally, it was investigated if Flavocoxid used in combination with Entecavir could potentiate its anti-HBV activity. MATERIALS AND METHODS: Hepatoma cells replicating HBV were treated with Flavocoxid, or Entecavir alone or in combination for up to 5 days...
October 10, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28943290/anti-inflammatory-and-anti-arthritic-properties-of-naringenin-via-attenuation-of-nf-%C3%AE%C2%BAb-and-activation-of-the-heme-oxygenase-%C3%AF-ho%C3%AF-1-related-factor-2-pathway
#11
Rong Fan, Tong Pan, An-Li Zhu, Mei-Hong Zhang
BACKGROUND: Naringenin, a bioflavonoid present in various species of citrus fruit, tomatoes and grapes, has been shown to have various pharmacological effects. We evaluated the anti-arthritic potential of naringenin in formaldehyde-induced inflammation and complete Freund's adjuvant (CFA)-induced arthritis. METHODS: For both evaluations, rats were divided into groups of six. Different doses of naringenin (5, 10 and 20mg/kg) were used in the models. Body weight and the arthritic index were assessed...
April 13, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28935427/hesperidin-protects-against-chemically-induced-hepatocarcinogenesis-via-modulation-of-nrf2-are-ho-1-ppar%C3%AE-and-tgf-%C3%AE-1-smad3-signaling-and-amelioration-of-oxidative-stress-and-inflammation
#12
Ayman M Mahmoud, Hanaa M Mohammed, Sally M Khadrawy, Sanaa R Galaly
Hesperidin is a plant-derived bioflavonoid with promising antitumor efficacy, though the underlying mechanisms of action remain poorly elucidated. Thus, we evaluated the in vivo chemopreventive effect of hesperidin against diethylnitrosamine (DEN)-induced hepatocarcinogenesis. We demonstrated the modulatory effect of hesperidin on Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling. Hepatocarcinogenesis was initiated with DEN and promoted with carbon tetrachloride (CCl4). DEN/CCl4-induced rats were treated with 50 and 100 mg/kg hesperidin throughout the experiment...
November 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28903082/hesperidin-a-citrus-bioflavonoid-alleviates-trichloroethylene-induced-oxidative-stress-in-drosophila-melanogaster
#13
Amos Olalekan Abolaji, Oluwatoyin Victoria Babalola, Abimbola Kehinde Adegoke, Ebenezer Olatunde Farombi
Trichloroethylene (TCE) is a chlorinated organic pollutant of groundwater with diverse toxic effects in animals and humans. Here, we investigated the ameliorative role of hesperidin, a citrus bioflavonoid on TCE-induced toxicity in Drosophila melanogaster. Four groups of D. melanogaster (50 flies/vial, with 5 vials/group) were exposed to ethanol (2.5%, control), HSP (400mg/10g diet), TCE (10μM/10g diet) and TCE (10μM/10g diet)+HSP (400mg/10g diet) respectively in the diet for 5days. Then, selected oxidative stress and antioxidant markers were evaluated...
September 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28899694/anti-atherosclerotic-effect-of-hesperidin-in-ldlr-mice-and-its-possible-mechanism
#14
Ye-Zi Sun, Jian-Fei Chen, Li-Min Shen, Ji Zhou, Cui-Fang Wang
Hesperidin, a citrus bioflavonoid, exerts numerous pharmacological activities. However, its protective effect against atherosclerosis in vivo remains poorly understood. In the present study, we aimed to observe the effects of hesperidin on high fat diet (HFD)-induced atherosclerosis using LDL receptor deficient (LDLr(-/-)) mice. After 12 weeks of treatment, the animals were sacrificed. The blood samples were collected for further analysis. Mouse peritoneal macrophages were collected. Hepatic lipid content, quantification of atherosclerosis, assessment of oxidative stress and inflammation, gene expressions were performed on liver and aorta samples...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28853026/folate-receptor-targeted-bioflavonoid-genistein-loaded-chitosan-nanoparticles-for-enhanced-anticancer-effect-in-cervical-cancers
#15
Limei Cai, Rufen Yu, Xi Hao, Xiangcui Ding
In this study, novel folic acid-conjugated chitosan nanoparticle was formulated for specific delivery of bioflavonoid, Genistein (GEN), to the cervical cancer cells. The prepared GEN-loaded chitosan nanoparticles (GCN) and folic acid-conjugated GCN (FGCN) showed smaller size with a controlled drug release profile. FGCN exhibited enhanced internalization potential in HeLa cells than that of GCN. The specific internalization of FGCN was mainly due to the affinity of folic acid (FA) with FRs-α which is present in large numbers in HeLa cells...
August 29, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28852397/neuroprotective-potential-of-quercetin-in-combination-with-piperine-against-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-induced-neurotoxicity
#16
Shamsher Singh, Sumit Jamwal, Puneet Kumar
1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that selectively damages dopaminergic neurons in the substantia nigra pars compacta and induces Parkinson's like symptoms in rodents. Quercetin (QC) is a natural polyphenolic bioflavonoid with potent antioxidant and anti-inflammatory properties but lacks of clinical attraction due to low oral bioavailability. Piperine is a well established bioavailability enhancer used pre-clinically to improve the bioavailability of antioxidants (e.g., Quercetin)...
July 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28832643/effect-of-naringin-on-gp120-induced-injury-mediated-by-p2x7-receptors-in-rat-primary-cultured-microglia
#17
Qiang Chen, Hui Wu, Jia Tao, Chenglong Liu, Zeyu Deng, Yang Liu, Guoqiao Chen, Baoyun Liu, Changshui Xu
Human immunodeficiency virus type-1 (HIV-1) envelope glycoprotein 120 has been shown to activate microglia, causing release of inflammatory and toxic factors. The P2X7 receptor, primarily expressed on microglia, is closely associated with inflammation. Naringin, a plant bioflavonoid, has anti-inflammatory and anti-oxidative properties. We hypothesized that P2X7 receptor mediated gp120-induced injury in primary cultured microglia, and that naringin would have a protective effect. We showed that HIV-1 gp120 peptide (V3 loop, fragment 308-331) appeared to induce apoptosis of primary cultured microglia...
2017: PloS One
https://www.readbyqxmd.com/read/28826911/rutin-alleviates-diabetic-cardiomyopathy-and-improves-cardiac-function-in-diabetic-apoeknockout-mice
#18
Ruo Huang, Zhendong Shi, Li Chen, Yanqun Zhang, Jing Li, Yi An
Rutin, a natural bioflavonoid, has demonstrated anti-diabetic and anti-oxidative bioactivity. Oxidative stress is a potential therapeutic target for diabetic cardiomyopathy. We investigated whether rutinadministration (60mg/kg body weight) reduces diabetic cardiomyopathy in a diabetic ApoE knock out mouse model. Diabetes was induced in ApoEknockout mice (male, C57BL/6 background) with a high fat diet combined with injection of streptozotocin. Cardiac function was evaluated by echocardiography and cardiac catheter hemodynamic analysis...
November 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28813782/urea-cycle-pathway-targeted-therapeutic-action-of-naringin-against-ammonium-chloride-induced-hyperammonemic-rats
#19
Arumugam Ramakrishnan, Natesan Vijayakumar
Ammonia is a well-known neurotoxin that causes liver disease and urea cycle disorder. Excessive ammonia content in the blood leads to hyperammonemic condition and affects both excitatory and inhibitory neurotransmission including brain edema and coma. Naringin, a plant bioflavonoid present in various citrus fruits and mainly extracted from the grape fruit. This study was designed to assess the protective effect of naringin on ammonium chloride (NH4Cl) induced hyperammonemic rats. Experimental hyperammonemia was induced by intraperitoneal injections (i...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28811686/influence-of-the-flavonoid-quercetin-on-antioxidant-status-lipid-peroxidation-and-histopathological-changes-in-hyperammonemic-rats
#20
Sivamani Kanimozhi, Pakkiri Bhavani, Perumal Subramanian
We have studied the ability of quercetin (a bioflavonoid) in tackling oxidative stress to alleviate the symptoms during ammonium chloride-induced hyperammonemia. Hyperammonemia was induced by the treatment of ammonium chloride (AC) 100 mg/kg b.w for 56 days. Hyperammonemic rats exhibited reduced urea (in plasma) and increased ammonia (in blood), uric acid (in plasma), creatinine (in serum), oxidative stress markers (thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HP) and decreased levels of antioxidants (enzymatic and non-enzymatic) superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) in plasma and tissues (liver and brain) vitamins E and C (in plasma))...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
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