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https://www.readbyqxmd.com/read/28614059/apigenin-sensitizes-bel-7402-adm-cells-to-doxorubicin-through-inhibiting-mir-101-nrf2-pathway
#1
Ai-Mei Gao, Xiao-Yu Zhang, Zun-Ping Ke
Chemo-resistance is one of the main obstacle in hepatocellular carcinoma therapy. Apigenin as a natural bioflavonoid has been exhibited anti-cancer properties in various malignant cancers. The aim of this study is to evaluate the potential chemo-sensitization effect of apigenin in doxorubicin-resistant hepatocellular carcinoma cell line BEL-7402/ADM and to investigate its possible mechanism. We found that apigenin significantly reversed doxorubicin sensitivity and induced caspase-dependent apoptosis in BEL-7402/ADM cells...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28606468/protective-effect-of-rutin-on-humoral-and-cell-mediated-immunity-in-rat-model
#2
Aditya Ganeshpurkar, Ajay K Salujaa
Diet and dietary intake can persuade the development, safeguard and proper functioning of immune system. Ruin, an important bioflavonoid, is abundantly found in various foodstuffs. Rutin has been acknowledged for its protective and beneficial effects on various aspects of the biological system. The present study was aimed to examine the effect of rutin on the regulation of the immune response in experimental animal models. Effect of rutin of cellular immunity was determined by delayed-type hypersensitivity (DTH) response, carbon clearance assay, leucocyte mobilization test, and cyclophosphamide-induced myelosuppression, whereas humoral immunity was analysed by the haemagglutinating antibody (HA) titre assay...
June 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28577870/mitochondria-as-the-target-for-the-modulatory-effect-of-curcumin-in-oxaliplatin-induced-toxicity-in-isolated-rat-liver-mitochondria
#3
Mohammad Waseem, Suhel Parvez, Heena Tabassum
BACKGROUND AND AIMS: To explore hepatoprotective action of curcumin (CMN, a bioflavonoid) on oxaliplatin (Oxa)-triggered mitochondrial oxidative stress and respiratory chain complexes in liver of rats. Oxa is a ubiquitously utilized platinum-based chemotherapeutic agent commonly used for the treatment of colorectal cancer. Mitochondria have recently emerged as targets for anticancer drugs in several kinds of toxicity including hepatotoxicity that can lead to neoplastic disease. There is a dearth of evidence involving the role of mitochondria in mediating Oxa-evoked hepatotoxicity and its underlying mechanism is still debatable...
January 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28559218/argpyrimidine-tagged-rutin-encapsulated-biocompatible-ethylene-glycol-dimers-nanoparticles-application-for-targeted-drug-delivery-in-experimental-diabetes-part-2
#4
Abhishek Bhattacherjee, Abhay Sankar Chakraborti
Diabetes mellitus is characterized by hyperglycemia and associated complications. However, long-term diabetes control is not often sustained by currently available therapeutic approaches. Research on nanoparticle-mediated drug delivery systems is in progress. Here we have tested a ligand (argpyrimidine)-tagged drug (rutin)-encapsulated biocompatible (ethylene glycol dimers) nanoparticle for targeted drug delivery in streptozotocin-induced diabetic rats. Argpyrimidine, being an advanced glycation end product (AGE), directs the nanoparticles to interact with cell surface receptors of AGEs (RAGE) and delivers the drug into the cells...
May 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28512407/severe-rhabdomyolysis-during-treatment-with-trabectedin-in-combination-with-a-herbal-drug-in-a-patient-with-metastatic-synovial-sarcoma-a-case-report
#5
Angela Damato, Mario Larocca, Ermanno Rondini, Massimo Menga, Carmine Pinto, Annibale Versari
Rhabdomyolysis is defined as dissolution of striped muscle characterized by leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome. This is an uncommon side effect of trabectedin which is used in second-line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. Here, we describe a case of reversible rhabdomyolysis in a male patient with recurrent metastatic synovial sarcoma of the hand, with marked (18)F-FDG uptake into his skeletal muscles, after 4 cycles of trabectedin, and who at the same time was taking an alternative medicine (bioflavonoids) suspected of triggering this adverse event...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28507483/effects-of-hesperidin-on-formaldehyde-induced-toxicity-in-pregnant-rats
#6
Sameha Merzoug, Mohamed Lamine Toumi
This experimental study aimed to investigate the protective effect of a bioflavonoid, hesperidin (HP), on formaldehyde (FA)-related pathophysiological and behavioral outcomes in pregnant rats and developmental aspects in their offspring. Female Wistar rats were subjected to perigestational exposure to FA (2 mg/kg/day per os) with a concomitant treatment with HP (50 mg/kg/day per os). Pregnant rats were weighed throughout gestation and tested in two behavioral paradigms (elevated plus-maze and open field) at gestational days (GD) 1, 10 and 19 to evaluate the anxiety-like behavior and locomotive alterations...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28498848/modulation-of-the-growth-and-metabolic-response-of-cyanobacteria-by-the-multifaceted-activity-of-naringenin
#7
Beata Żyszka, Mirosław Anioł, Jacek Lipok
The interactions between the plant-derived bioflavonoid, naringenin, and prokaryotic microalgae representatives (cyanobacteria), were investigated with respect to its influence on the growth and metabolic response of these microorganisms. To achieve reliable results, the growth of cyanobacteria was determined based on measurements of chlorophyll content, morphological changes were assessed through microscopic observations, and the chemical response of cells was determined using liquid and gas chromatography (HPLC; GC-FID)...
2017: PloS One
https://www.readbyqxmd.com/read/28440404/troxerutin-protects-against-diabetic-cardiomyopathy-through-nf%C3%A2-%C3%AE%C2%BAb-akt-irs1-in-a-rat-model-of-type-2-diabetes
#8
Yongzhi Yu, Guanzhong Zheng
Troxerutin is a bioflavonoid, which can be used to treat venous disorders, thrombosis and cerebrovascular diseases. Recent studies have demonstrated that it may also be used to prevent edemas. However, it is not known whether troxerutin protects against the cardiomyopathic complications of diabetes. In the present study, a rat model of type 2 diabetes was used to investigate the potential for troxerutin to protect against diabetic cardiomyopathy, through changes to nuclear factor‑κB (NF‑κB) expression...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28395574/naringenin-a-bioflavonoid-impairs-the-reproductive-potential-of-male-mice
#9
Pavitra Ranawat, Nikita Bakshi
Present study analyzed the effect of naringenin, a bioflavonoid, on male reproductive function in adult mouse, after intraperitoneal treatment with varying concentrations of naringenin (2, 8 and 20 mg/kg b.wt.) for two weeks. Naringenin increased the generation of reactive oxygen species and lipid peroxidation in the testis with concomitant decrease in sperm count and motility in a dose-dependent manner. Activities of antioxidant enzymes catalase, superoxide dismutase, glutathione peroxidase and levels of reduced glutathione were found to be decreased in a dose-dependent manner...
April 10, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28387736/optimization-of-ionic-liquid-assisted-extraction-of-biflavonoids-from-selaginella-doederleinii-and-evaluation-of-its-antioxidant-and-antitumor-activity
#10
Dan Li, Yan Qian, Yu-Jia Tian, Shi-Meng Yuan, Wei Wei, Gang Wang
As new green solvents, ionic liquids (ILs) have been generally applied in the extraction and separation of natural product. In this study, microwave assisted extraction based on IL (IL-MAE) was firstly employed to extract total biflavonoids from Selaginella doederleinii. Based on single-factor experiment, microwave power (300-700 W), extract time (30-50 min) and extract temperature (40-60 °C) on total bioflavonoids and antioxidant activities of the extracts were further investigated by a Box-Behnken design of response surface methodology (RSM) selecting total bioflavonoids yields and IC50 of radical scavenging as index...
April 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28366538/morin-impedes-yap-nuclear-translocation-and-fosters-apoptosis-through-suppression-of-wnt-%C3%AE-catenin-and-nf-%C3%AE%C2%BAb-signaling-in-mst1-overexpressed-hepg2-cells
#11
NaveenKumar Perumal, MadanKumar Perumal, Anbarasu Kannan, Kumar Subramani, Devaraj Halagowder, NiranjaliDevaraj Sivasithamparam
Recent clinical and experimental evidences strongly acclaim Yes-associated protein (Yap), a key oncogenic driver in liver carcinogenesis, as a therapeutic target. Of the known multiple schemes to inhibit Yap activity, activation of Mammalian Sterile 20-like Kinase 1 (Mst1), an upstream regulator of Yap, appears to be a promising one. In this study, we hypothesize that morin, a bioflavonoid, mediates its anti-cancer effect through the activation of Mst1/hippo signaling in liver cancer cells. To test this hypothesis, both full length Mst1 (F-Mst1) and kinase active N-terminal Mst1 (N-Mst1)-overexpressed HepG2 cells were used...
March 31, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28362543/a-botanical-composition-mitigates-cartilage-degradations-and-pain-sensitivity-in-osteoarthritis-disease-model
#12
Mesfin Yimam, Young-Chul Lee, Laura Wright, Ping Jiao, Teresa Horm, Mei Hong, Lidia Brownell, Qi Jia
Osteoarthritis (OA) is a degenerative joint disease characterized by a progressive articular cartilage degradation manifested with significant functional impairment in consort with signs and symptoms of inflammation, stiffness, and loss of mobility. Current OA management is inadequate due to the lack of nominal therapies proven to be effective in hampering disease progression where symptomatic therapy focused intervention masks the primary etiology leading to irreversible structural damage. In this study, we describe the effect of UP1306, a composition containing a proprietary blend of two standardized extracts from the heartwood of Acacia catechu and the root bark of Morus alba, in maintaining joint structural integrity and alleviating OA associated symptoms in monosodium-iodoacetate (MIA)-induced rat OA disease model...
June 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28337019/apigenin-induced-lysosomal-degradation-of-%C3%AE-catenin-in-wnt-%C3%AE-catenin-signaling
#13
Chung-Ming Lin, Hsin-Han Chen, Chun-An Lin, Hui-Chung Wu, Jim Jinn-Chyuan Sheu, Hui-Jye Chen
The bioflavonoid apigenin has been shown to possess cancer-preventive and anti-cancer activities. In a drug screening, we found that apigenin can inhibit Wnt/β-catenin signaling, a pathway that participates in pivotal biological functions, which dis-regulation results in various human diseases including cancers. However, the underlying mechanism of apigenin in this pathway and its link to anti-cancer activities remain largely unknown. Here we showed that apigenin reduced the amount of total, cytoplasmic, and nuclear β-catenin, leading to the suppression in the β-catenin/TCF-mediated transcriptional activity, the expression of Wnt target genes, and cell proliferation of Wnt-stimulated P19 cells and Wnt-driven colorectal cancer cells...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28320087/the-renoprotective-activity-of-hesperetin-in-cisplatin-induced-nephrotoxicity-in-rats-molecular-and-biochemical-evidence
#14
Mukesh Kumar, Vicky Dahiya, Eshvendar Reddy Kasala, Lakshmi Narendra Bodduluru, Mangala Lahkar
Nephrotoxicity remain a major life-threatening complication in cancer patients on cisplatin chemotherapy. In this study, we investigated the protective effect and possible cellular mechanism of the hesperetin, a naturally-occurring bioflavonoid against cisplatin-induced renal injury in rats. Hesperetin was administered at a dose of 50mg/kg and 100mg/kg orally for 10days and cisplatin (7.5mg/kg, ip) was administered on the 5th day of experiment. Cisplatin induced nephrotoxicity was evidenced by alteration in the level of markers such as blood urea nitrogen, creatinine, serum albumin and severe histopathological changes in kidney...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28284752/troxerutin-exerts-neuroprotection-in-6-hydroxydopamine-lesion-rat-model-of-parkinson-s-disease-possible-involvement-of-pi3k-er%C3%AE-signaling
#15
Tourandokht Baluchnejadmojarad, Nida Jamali-Raeufy, Sedigheh Zabihnejad, Nafiseh Rabiee, Mehrdad Roghani
Parkinson's disease (PD) is a neurodegenerative disease with progressive loss of mesencephalic dopaminergic neurons of the substantia nigra and with multiple incapacitating motor and non-motor symptoms. Troxerutin is a natural bioflavonoid with nephro- and hepato-protective, antioxidant, and anti-inflammatory properties. In this study, we evaluated its possible neuroprotective effect in 6-hydroxydopamine (6-OHDA) rat model of PD. Intrastriatal 6-OHDA-lesioned rats were pretreated with troxerutin at a dose of 150mg/kg/day for 1 week...
April 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28282786/galangin-potentiates-human-breast-cancer-to-apoptosis-induced-by-trail-through-activating-ampk
#16
Wei Song, Chong-Yang Yan, Qian-Qian Zhou, Lin-Lin Zhen
Breast cancer is reported as the most frequent tumor with limited treatments among the female worldwide. Galangin, a natural active compound 3, 5, 7-trihydroxyflavone, is a type of bioflavonoid isolated from the Alpinia galangal root and suggested to induce apoptosis in various cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an effective anti-tumor agent for human breast cancer. Promoted expression of CHOP, a down-streaming transcription factor for endoplasmic reticulum stress (ER stress), enhanced death factor 4 (DR4) activity and accelerated reactive oxygen species (ROS) as well as cell death...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28263808/structural-characterization-and-bioavailability-of-ternary-nanoparticles-consisting-of-amylose-%C3%AE-linoleic-acid-and-%C3%AE-lactoglobulin-complexed-with-naringin
#17
Tao Feng, Ke Wang, Fangfang Liu, Ran Ye, Xiao Zhu, Haining Zhuang, Zhimin Xu
Naringin is a bioflavonoid that is rich in citrus plants and possesses enormous health benefits. However, the use of naringin as a nutraceutical is significantly limited by its low bioavailability. In this study, a novel water-soluble ternary nanoparticle material consisting of amylose, α-linoleic acid and β-lactoglobulin was developed to encapsulate naringin to improve its bioavailability. The physicochemical characteristics of the ternary nanoparticle-naringin inclusion complex were analysed by ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), high-resolution transmission electron microscopy (TEM), X-ray diffractometry (XRD) and particle size distribution...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28251795/quercetin-simultaneously-induces-g0-g1-phase-arrest-and-caspase-mediated-crosstalk-between-apoptosis-and-autophagy-in-human-leukemia-hl-60-cells
#18
Junn-Liang Chang, Jyh-Ming Chow, Jer-Hwa Chang, Yu-Ching Wen, Yung-Wei Lin, Shun-Fa Yang, Wei-Jiunn Lee, Ming-Hsien Chien
Quercetin is a plant-derived bioflavonoid with high anticancer activity in various tumors. Herein, the molecular mechanisms by which quercetin exerts its anticancer effects against HL-60 acute myeloid leukemia (AML) cells were investigated. Results showed that quercetin suppressed cell proliferation in the HL-60 cell line in vitro and in vivo. Quercetin-induced G0 /G1 -phase arrest occurred when expressions of cyclin-dependent kinase (CDK)2/4 were inhibited and the CDK inhibitors, p16 and p21, were induced...
March 2, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28177765/diosmin-attenuates-radiation-induced-hepatic-fibrosis-by-boosting-ppar-%C3%AE-expression-and-hampering-mir-17-5p-activated-canonical-wnt-%C3%AE-catenin-signaling
#19
Hesham Farouk Hasan, Mohamed Khairy Abdel-Rafei, Shereen Mohamed Galal
BACKGROUND: Liver fibrosis is one of the major complications from upper right quadrant radiotherapy. MicroRNA-17-5p (miR-17-5p) is hypothesized to act as a regulator of hepatic stellate cell (HSCs) activation by activation of the canonical Wnt-β-catenin pathway. Diosmin (Dios), a citrus bioflavonoid, is known to possess potent antioxidant, anti-inflammatory, and anti-apoptotic properties. PURPOSE: To explore the molecular mechanisms that underlie radiation-induced liver fibrosis, and to evaluate the possible influence of Dios on the miR-17-5p-Wnt-β-catenin signaling axis during fibrogenesis provoked by irradiation (IRR) in rats...
June 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28152319/evaluation-of-plasma-oxidative-stress-with-or-without-antioxidant-supplementation-in-superficial-partial-thickness-burn-patients-a-pilot-study
#20
Edoardo Raposio, Michele P Grieco, Edoardo Caleffi
BACKGROUND: Oxidative stress is one of the main causes of pathophysiological alterations observed during burn injury. The present pilot study aimed to determine whether a specific oral antioxidant supplementation could in any way influence free radical blood values in patients affected by superficial partial thickness burns. MATERIALS AND METHODS: Plasma oxidants and plasma antioxidant capacity were analysed in 20 superficial partial thickness burn patients for a 2-week period; patients were randomly divided into two groups, one of which was supported with a specifically designed oral antioxidant formula (Squalene 100 mg, Vitamin C 30 mg, Coenzyme Q10 10 mg, Zinc 5 mg, Beta Carotene 3...
February 2, 2017: Journal of Plastic Surgery and Hand Surgery
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