Margaret Meagher, Harris Krause, Andrew Elliott, Alex Farrell, Emmanuel S Antonarakis, Bruno Bastos, Elisabeth I Heath, Christina Jamieson, Tyler F Stewart, Aditya Bagrodia, Chadi Nabhan, Matt Oberley, Rana R McKay, Amirali Salmasi
BACKGROUND: Non-canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC) tumors to characterize non-canonical WNT signaling through WNT5A, ROR1, ROR2, or FZD2 expression. METHODS: NextGen Sequencing of DNA (592 genes or WES)/RNA (WTS) was performed for 4125 UC tumors submitted to Caris Life Sciences...
April 2024: Cancer Medicine