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https://www.readbyqxmd.com/read/29033786/wnt5a-promotes-cortical-neuron-survival-by-inhibiting-cell-cycle-activation
#1
Li Zhou, Di Chen, Xu-Ming Huang, Fei Long, Hua Cai, Wen-Xia Yao, Zhong-Cheng Chen, Zhi-Jian Liao, Zhe-Zhi Deng, Sha Tan, Yi-Long Shan, Wei Cai, Yu-Ge Wang, Ri-Hong Yang, Nan Jiang, Tao Peng, Ming-Fan Hong, Zheng-Qi Lu
β-Amyloid protein (Aβ) is thought to cause neuronal loss in Alzheimer's disease (AD). Aβ treatment promotes the re-activation of a mitotic cycle and induces rapid apoptotic death of neurons. However, the signaling pathways mediating cell-cycle activation during neuron apoptosis have not been determined. We find that Wnt5a acts as a mediator of cortical neuron survival, and Aβ42 promotes cortical neuron apoptosis by downregulating the expression of Wnt5a. Cell-cycle activation is mediated by the reduced inhibitory effect of Wnt5a in Aβ42 treated cortical neurons...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29030569/active-gsk3%C3%AE-and-an-intact-%C3%AE-catenin-tcf-complex-are-essential-for-the-differentiation-of-human-myogenic-progenitor-cells
#2
C C Agley, F C Lewis, O Jaka, N R Lazarus, C Velloso, P Francis-West, G M Ellison-Hughes, S D R Harridge
Wnt-β-catenin signalling is essential for skeletal muscle myogenesis during development, but its role in adult human skeletal muscle remains unknown. Here we have used human primary CD56(Pos) satellite cell-derived myogenic progenitors obtained from healthy individuals to study the role of Wnt-β-catenin signalling in myogenic differentiation. We show that dephosphorylated β-catenin (active-β-catenin), the central effector of the canonical Wnt cascade, is strongly upregulated at the onset of differentiation and undergoes nuclear translocation as differentiation progresses...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29029059/canonical-wnt-%C3%AE-catenin-signaling-regulates-postnatal-mouse-epididymal-development-but-does-not-affect-epithelial-cell-differentiation
#3
Manish Kumar, Pradeep S Tanwar
The epithelial lining of epididymis establishes an optimal environment in which spermatozoa acquire the ability to fertilize an oocyte. This highly specialized organ develops from a simple embryonic tube known as the Wolffian duct (WD). How the simple columnar epithelium of WD acquires the complex features of the adult epididymal epithelium is currently unclear. During these first few weeks after birth, the epididymal epithelium undergoes significant changes and by five weeks, consists of four different cell types...
October 5, 2017: Endocrinology
https://www.readbyqxmd.com/read/29028954/1-benzyl-indole-3-carbinol-is-a-highly-potent-new-small-molecule-inhibitor-of-wnt-%C3%AE-catenin-signaling-in-melanoma-cells-that-coordinately-inhibits-cell-proliferation-and-disrupts-expression-of-microphthalmia-associated-transcription-factor-isoform-m
#4
Aishwarya Kundu, Michelle G Khouri, Sheila Aryana, Gary L Firestone
1-Benzyl-indole-3-carbinol (1-benzyl-I3C), a synthetic analogue of the crucifer derived natural phytochemical I3C, displayed significantly wider sensitivity and anti-proliferative potency in melanoma cells than the natural compound. Unlike I3C, which targets mainly oncogenic BRAF-expressing cells, 1-benzyl I3C effectively inhibited proliferation of melanoma cells with a more extensive range of mutational profiles, including those expressing wild type BRAF. In both cultured melanoma cell lines and in vivo in melanoma cell-derived tumor xenografts, 1-benzyl-I3C disrupted canonical Wnt/β-catenin signaling that resulted in the down regulation of β-catenin protein levels with a concomitant increase in levels of the β-catenin destruction complex components GSK3β and Axin...
September 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29026640/directing-the-osteoblastic-and-chondrocytic-differentiations-of-mesenchymal-stem-cells-matrix-vs-induction-media
#5
Jing He, Jianglong Guo, Bo Jiang, Ruijuan Yao, Yao Wu, Fang Wu
While both induction culture media and matrix have been reported to regulate the stem cell fate, little is known about which factor plays a more decisive role in directing the MSC differentiation lineage as well as the underlying mechanisms. To this aim, we seeded MSCs on HA-collagen and HA-synthetic hydrogel matrixes, which had demonstrated highly different potentials toward osteoblastic and chondrocytic differentiation lineages, respectively, and cultured them with osteogenic, chondrogenic and normal culture media, respectively...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29026198/ctbp2-mediated-%C3%AE-catenin-regulation-is-required-for-exit-from-pluripotency
#6
Tae Wan Kim, Sojung Kwak, Jihoon Shin, Byung-Hee Kang, Sang-Eun Lee, Min Young Suh, Jae-Hwan Kim, In-Young Hwang, Jong-Hyuk Lee, Jinmi Choi, Eun-Jung Cho, Hong-Duk Youn
The canonical Wnt pathway is critical for embryonic stem cell (ESC) pluripotency and aberrant control of β-catenin leads to failure of exit from pluripotency and lineage commitments. Hence, maintaining the appropriate level of β-catenin is important for the decision to commit to the appropriate lineage. However, how β-catenin links to core transcription factors in ESCs remains elusive. C-terminal-binding protein (CtBP) in Drosophila is essential for Wnt-mediated target gene expression. In addition, Ctbp acts as an antagonist of β-catenin/TCF activation in mammals...
October 13, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29021569/cushioning-the-cartilage-a-canonical-wnt-restricting-matter
#7
REVIEW
Silvia Monteagudo, Rik J Lories
Wnt signalling pathways have key roles in joint development, homeostasis and disease, particularly in osteoarthritis. New data is starting to reveal the importance of tightly regulating canonical Wnt signalling pathway activation to maintain homeostasis and health in articular cartilage. In addition to the presence of different Wnt antagonists that limit pathway activation in articular cartilage, the reciprocal crosstalk between the canonical and non-canonical cascades and competitive antagonism between different Wnt ligands seem to be critical in restraining excessive Wnt pathway activation...
October 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29021340/downregulation-of-the-wnt-%C3%AE-catenin-signaling-pathway-by-cacnb4
#8
Mohamad Rima, Marwa Daghsni, Anaïs Lopez, Ziad Fajloun, Lydie Lefrancois, Mireia Dunach, Yasuo Mori, Philippe Merle, Juan L Brusés, Michel de Waard, Michel Ronjat
The β4 isoform of the β-subunits of Voltage-Gated Calcium Channel regulates cell proliferation and cell cycle progression. Herein we show that co-expression of the β4-subunit with actors of the canonical Wnt/β-catenin signaling pathway in a hepatoma cell line inhibits Wnt responsive gene transcription and decreases cell division, in agreement with the role of the Wnt pathway in cell proliferation. β4-subunit-mediated inhibition of Wnt signaling is observed in the presence of LiCl, an inhibitor of GSK3 that promotes β-catenin translocation to the nucleus...
October 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29021338/a-daple-akt-feed-forward-loop-enhances-non-canonical-wnt-signals-by-compartmentalizing-%C3%AE-catenin
#9
Nicolas Aznar, Nina Sun, Ying Dunkel, Jason Ear, Matthew D Buschman, Pradipta Ghosh
Cellular proliferation is antagonistically regulated by canonical and non-canonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the non-canonical Wnt signaling pathway and antagonistically inhibits canonical Wnt responses. Here we demonstrate that the PI3-K→Akt pathway serves as a positive feedback loop that further enhances non-canonical Wnt signals by compartmentalizing β-catenin. By phosphorylating the phosphoinositide(PI)-binding domain of Daple, Akt abolishes Daple's ability to bind PI3-P-enriched endosomes that engage dynein motor complex for long-distance trafficking of β-catenin/E-cadherin complexes to pericentriolar recycling endosomes (PCREs)...
October 11, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28982588/low-1-level-mechanical-vibration-improves-bone-microstructure-tissue-mechanical-properties-and-porous-titanium-implant-osseointegration-by-promoting-anabolic-response-in-type-1-diabetic-rabbits
#10
Da Jing, Zedong Yan, Jing Cai, Shichao Tong, Xiaokang Li, Zheng Guo, Erping Luo
Type 1 diabetes mellitus (T1DM) is associated with reduced bone mass, increased fracture risk, and impaired bone defect regeneration potential. These skeletal complications are becoming important clinical challenges due to the rapidly increasing T1DM population, which necessitates developing effective treatment for T1DM-associated osteopenia/osteoporosis and bone trauma. This study aims to investigate the effects of whole-body vibration (WBV), an easy and non-invasive biophysical method, on bone microstructure, tissue-level mechanical properties and porous titanium (pTi) osseointegration in alloxan-diabetic rabbits...
October 2, 2017: Bone
https://www.readbyqxmd.com/read/28981597/effects-of-cannabidiol-interactions-with-wnt-%C3%AE-catenin-pathway-and-ppar%C3%AE-on-oxidative-stress-and-neuroinflammation-in-alzheimer-s-disease
#11
Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée
Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary plaque deposits. AD shows oxidative stress and chronic inflammation. In AD, canonical Wingless-Int (Wnt)/β-catenin pathway is downregulated, whereas peroxisome proliferator-activated receptor γ (PPARγ) is increased. Downregulation of Wnt/β-catenin, through activation of glycogen synthase kinase-3β (GSK-3β) by Aβ, and inactivation of phosphatidylinositol 3-kinase/Akt signaling involve oxidative stress in AD...
October 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28973524/liver-cyst-gene-knockout-in-cholangiocytes-inhibits-cilium-formation-and-wnt-signaling
#12
Edgar S Wills, René H M Te Morsche, Jeroen van Reeuwijk, Nicola Horn, Iris Geomini, Liyanne F M van de Laarschot, Dorus A Mans, Marius Ueffing, Karsten Boldt, Joost P H Drenth, Ronald Roepman
Mutations in the PRKCSH, SEC63, and LRP5 genes cause autosomal dominant polycystic liver disease (ADPLD). The proteins products of PRKCSH (alias GIIB) and SEC63 function in protein quality control and processing in the endoplasmic reticulum (ER), while LRP5 is implicated in Wnt/β-catenin signaling. To identify common denominators in the PLD pathogenesis, we mapped the PLD interactome by affinity proteomics, employing both HEK293T cells and H69 cholangiocytes. Identification of known complex members, such as glucosidase IIA (GIIA) for PRKCSH, and SEC61A1 and SEC61B for SEC63, confirmed the specificity of the analysis...
August 14, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28966723/extracellular-ldlr-repeats-modulate-wnt-signaling-activity-by-promoting-lrp6-receptor-endocytosis-mediated-by-the-itch-e3-ubiquitin-ligase
#13
Sapna Vijayakumar, Guizhong Liu, Huei-Chi Wen, Yaa Abu, Robert Chong, Horacio Nastri, Gadi G Bornstein, Zhen-Qiang Pan, Stuart A Aaronson
The LOW-density lipoprotein related protein 6 (LRP6) receptor is an important effector of canonical Wnt signaling, a developmental pathway, whose dysregulation has been implicated in various diseases including cancer. The membrane proximal low-density lipoprotein (LDL) receptor repeats in LRP6 exhibit homology to ligand binding repeats in the LDL receptor (LDLR), but lack known function. We generated single amino acid substitutions of LRP6-LDLR repeat residues, which are highly conserved in the human LDLR and mutated in patients with Familial Hypercholesteremia (FH)...
July 2017: Genes & Cancer
https://www.readbyqxmd.com/read/28960852/novel-mutation-of-lrp6-identified-in-chinese-han-population-links-canonical-wnt-signaling-to-neural-tube-defects
#14
Zhiwen Shi, Xueyan Yang, Bin-Bin Li, Shuxia Chen, Luming Yang, Liangping Cheng, Ting Zhang, Hongyan Wang, Yufang Zheng
BACKGROUND: Neural tube defects (NTDs), the second most frequent cause of human congenital abnormalities, are debilitating birth defects due to failure of neural tube closure. It has been shown that noncanonical WNT/planar cell polarity (PCP) signaling is required for convergent extension (CE), the initiation step of neural tube closure (NTC). But the effect of canonical WNT//β-catenin signaling during NTC is still elusive. LRP6 (low density lipoprotein receptor related proteins 6) was identified as a co-receptor for WNT/β-catenin signaling, but recent studies showed that it also can mediate WNT/PCP signaling...
September 29, 2017: Birth defects research
https://www.readbyqxmd.com/read/28960204/what-dkktates-where-to-metastasize
#15
Wei Zheng, Jeffrey W Pollard
Cancer cells preferentially metastasize to certain organs. A study in mouse models of breast cancer shows that the DKK1 negative regulator of WNT signalling inhibits tropism to the lung, but enhances tropism to the bone due to the differential regulation of canonical and non-canonical WNT signalling in the two microenvironments.
September 29, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28958934/cinnamaldehyde-induces-cell-apoptosis-mediated-by-a-novel-circular-rna-hsa_circ_0043256-in-non-small-cell-lung-cancer
#16
Fang Tian, C T Yu, W D Ye, Qian Wang
Cinnamaldehyde (CA), the primary chemical component of the Chinese traditional herb Cinnamomum cassia, is an effective cytotoxic agent against various human cancers. Our previous study indicated that CA could trigger apoptosis in three kinds of non-small cell lung cancer (NSCLC) cells. However, CA mechanism of action in NSCLC has not been unveiled completely. Herein, we showed that a novel circular RNA hsa_circ_0043256 was upregulated in NSCLC cells in response to CA treatment, as detected by microarray and real-time PCR...
September 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28952290/study-of-gsk3b-inhibitors-sb415286-and-sb216763-to-improve-osteoblastic-differentiation-on-microstructured-titanium
#17
S Lumetti, E Calciolari, L Parisi, A Toffoli, S Mazzotta, S Ferrillo, G Ierardo, G M Macaluso, C Galli, E Manfredi
Rough titanium surfaces enhance cell response to activation of Wnt canonical signalling, a pathway required for osteoblast differentiation. The present study investigated the effects of GSK3β-inhibitors SB216763 and SB415286 on osteoblastic differentiation on titanium surfaces with different topography and wettability. Osteoblastic MC3T3 cells were plated on smooth (Pickled), sand-blasted/acid-etched (SLA) or hyper hydrophilic SLA (modSLA) titanium discs and transfected with a reporter vector sys-tem for Wnt canonical signalling...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28943452/long-non-coding-rna-hnf1a-as1-mediated-repression-of-mir-34a-sirt1-p53-feedback-loop-promotes-the-metastatic-progression-of-colon-cancer-by-functioning-as-a-competing-endogenous-rna
#18
Changyi Fang, Shenglong Qiu, Feng Sun, Wei Li, Ziqi Wang, Ben Yue, Xuesong Wu, Dongwang Yan
In recent years, accumulating evidence indicates that long noncoding RNAs (lncRNAs) have emerged as powerful influence factors in the progression of multiple malignancies. Dysregulation of lncRNA HNF1A-antisense 1 (HNF1A-AS1) has been reported in many types of human cancers, and studies on HNF1A-AS1 function in cancers revealed that HNF1A-AS1could act as either oncogene or tumor suppressor. Nevertheless, the functional involvement of HNF1A-AS1 in colon cancer remains unknown. In this study, we reported that HNF1A-AS1 was frequently upregulated in colon cancer tissues and associated with poor prognosis...
September 21, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28943432/highly-expressed-lncrna-loc730101-promotes-lung-cancer-cell-growth-through-wnt-canonical-pathway
#19
Lei Liu, Yongxue Zhang, Wangkai Cao
Many long non-coding RNA (lncRNA) has recently been reported to be dysregulated and involved in the progression of non-small-cell lung cancer. However, the biological role of LOC730101 in NSCLC carcinogenesis remains unclear. In the present study, we found that LOC730101 was up-regulated in TCGA and GEO database, so were in NSCLC tissues and cell lines. Overexpression of LOC730101 prompted the proliferation of NSCLC both in vitro and in vivo while Silencing observed opposite phenomenon. Furthermore, we found that LOC730101 enhances the activity of Wnt/β-catenin signaling to promote the progression of cell cycle and ultimate promotes cell proliferation and growth...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28941461/nigericin-inhibits-epithelial-ovarian-cancer-metastasis-by-suppressing-the-cell-cycle-and-epithelial-mesenchymal-transition
#20
Wen Wang, Yan Zhao, Shujuan Yao, Xiujuan Cui, Wenying Pan, Wenqian Huang, Jiangang Gao, Taotao Dong, Shiqian Zhang
Epithelial ovarian cancer (EOC) has the highest mortality among various types of gynecological malignancies. Most patients die of metastasis and recurrence due to cisplatin resistance. Thus, it is urgent to develop novel therapies to cure this disease. CCK-8 assay showed that nigericin exhibited strong cytotoxicity on A2780 and SKOV3 cell lines. Flow cytometry indicated that nigericin could induce cell cycle arrest at G0/G1 phase and promote cell apoptosis. Boyden chamber assay revealed that nigericin could inhibit migration and invasion in a dose-dependent manner by suppressing epithelial-mesenchymal transition (EMT) in EOC cells...
August 2017: Biochemistry. Biokhimii︠a︡
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