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https://www.readbyqxmd.com/read/29453334/%C3%AE-catenin-independent-regulation-of-wnt-target-genes-by-ror2-and-atf2-atf4-in-colon-cancer-cells
#1
Oksana Voloshanenko, Uwe Schwartz, Dominique Kranz, Benedikt Rauscher, Michael Linnebacher, Iris Augustin, Michael Boutros
Wnt signaling is an evolutionarily conserved signaling route required for development and homeostasis. While canonical, β-catenin-dependent Wnt signaling is well studied and has been linked to many forms of cancer, much less is known about the role of non-canonical, β-catenin-independent Wnt signaling. Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. Gene expression profiling was performed after silencing of key components of Wnt signaling pathway and an iterative signature algorithm was applied to predict pathway-dependent gene signatures...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453044/micro-rna-1298-opposes-the-effects-of-chronic-oxidative-stress-on-human-trabecular-meshwork-cells-via-targeting-on-eif4e3
#2
Wu Ruibin, Xiaowei Zheng, Jiaying Chen, Xinyi Zhang, Xiayin Yang, Yuxian Lin
OBJECTIVE: This study aimed to investigate the effect and potential mechanism of miR-1298 in the progression of human trabecular meshwork (HTM) cells. MATERIAL AND METHODS: Expression of miR-1298 was assessed by quantitative real time PCR (qRT-PCR), as well as in HTM-1 and HTM-2 cells. Mature miR-1298 mimic, miR-1298 inhibitor, and si-EIF4E3 and their corresponding controls were transfected into HTM-1 and HTM-2 to obtain stable HTM cells. Luciferase reporter assay was used to verify regulation between miR-1298 and EIF4E3...
February 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29451203/a-growing-field-the-regulation-of-axonal-regeneration-by-wnt-signaling
#3
REVIEW
Armando L Garcia, Adanna Udeh, Karthik Kalahasty, Abigail S Hackam
The canonical Wnt/β-catenin pathway is a highly conserved signaling cascade that plays critical roles during embryogenesis. Wnt ligands regulate axonal extension, growth cone guidance and synaptogenesis throughout the developing central nervous system (CNS). Recently, studies in mammalian and fish model systems have demonstrated that Wnt/β-catenin signaling also promotes axonal regeneration in the adult optic nerve and spinal cord after injury, raising the possibility that Wnt could be developed as a therapeutic strategy...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29445990/time-dependent-lxr-rxr-pathway-modulation-characterizes-capillary-remodeling-in-inflammatory-corneal-neovascularization
#4
Anthony Mukwaya, Anton Lennikov, Maria Xeroudaki, Pierfrancesco Mirabelli, Mieszko Lachota, Lasse Jensen, Beatrice Peebo, Neil Lagali
Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex and are activated in a time-dependent manner. Effective resolution of inflammation and associated angiogenesis in the cornea requires knowledge of these pathways and their time dependence, which has, to date, remained largely unexplored. Here, using a model of endogenous resolution of inflammation-induced corneal angiogenesis, we investigate the time dependence of inflammatory genes in effecting capillary regression and the return of corneal transparency...
February 14, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29443926/the-pleiotropic-effects-of-the-canonical-wnt-pathway-in-early-development-and-pluripotency
#5
REVIEW
Anchel de Jaime-Soguero, Willy Antoni Abreu de Oliveira, Frederic Lluis
The technology to derive embryonic and induced pluripotent stem cells from early embryonic stages and adult somatic cells, respectively, emerged as a powerful resource to enable the establishment of new in vitro models, which recapitulate early developmental processes and disease. Additionally, pluripotent stem cells (PSCs) represent an invaluable source of relevant differentiated cell types with immense potential for regenerative medicine and cell replacement therapies. Pluripotent stem cells support self-renewal, potency and proliferation for extensive periods of culture in vitro...
February 14, 2018: Genes
https://www.readbyqxmd.com/read/29442329/deregulation-of-zic-family-members-in-oncogenesis
#6
Rob Houtmeyers, Jabob Souopgui, Sabine Tejpar
In the last decade, the amount of investigations on the involvement of ZIC genes in the cancer field have exponentially expanded. In most cancer types, promoter methylation leads to silenced ZIC family members, but specific subsets of patients clearly show increased expression of one or head-to-head located ZIC genes in the respective tumor tissue. It is unclear at this stage how these transcription factors contribute to tumorigenesis, but the potential implications in pathways that are most frequently mutated in cancer such as the canonical Wnt, TGF-beta, and STAT-3 pathway are evident...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29442320/amphibian-zic-genes
#7
Christa Merzdorf, Jennifer Forecki
Studies in Xenopus laevis have greatly contributed to understanding the roles that the Zic family of zinc finger transcription factors play as essential drivers of early development. Explant systems that are not readily available in other organisms give Xenopus embryos a unique place in these studies, facilitated by the recent sequencing of the Xenopus laevis genome. A number of upstream regulators of zic gene expression have been identified, such as inhibition of BMP signaling, as well as calcium, FGF, and canonical Wnt signaling...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29440377/efficient-derivation-of-stable-primed-pluripotent-embryonic-stem-cells-from-bovine-blastocysts
#8
Yanina Soledad Bogliotti, Jun Wu, Marcela Vilarino, Daiji Okamura, Delia Alba Soto, Cuiqing Zhong, Masahiro Sakurai, Rafael Vilar Sampaio, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte, Pablo Juan Ross
Embryonic stem cells (ESCs) are derived from the inner cell mass of preimplantation blastocysts. From agricultural and biomedical perspectives, the derivation of stable ESCs from domestic ungulates is important for genomic testing and selection, genome engineering, and modeling human diseases. Cattle are one of the most important domestic ungulates that are commonly used for food and bioreactors. To date, however, it remains a challenge to produce stable pluripotent bovine ESC lines. Employing a culture system containing fibroblast growth factor 2 and an inhibitor of the canonical Wnt-signaling pathway, we derived pluripotent bovine ESCs (bESCs) with stable morphology, transcriptome, karyotype, population-doubling time, pluripotency marker gene expression, and epigenetic features...
February 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29439617/low-density-lipoprotein-receptor-related-protein-6-is-essential-for-trophoblast-survival-and-invasion
#9
Lei Li, Jipeng Wan, Jing Xue, Hongyan Li, Shan Wang, Qian Zhou, Yu Zhou, Xietong Wang
Remodeling of maternal spiral artery after the implantation of embryo relies on tightly regulated trophoblast functions and is pivotal to ensure the success of pregnancy. Low-density lipoprotein receptor-related protein 6 (LRP6) is implicated in angiogenesis and several vascular diseases, but its function in trophoblast regulation is still not fully understood. We aimed to investigate the involvement of LRP6 in trophoblast functions during maternal spiral artery remodeling. HTR-8/SVneo cells, a trophoblast cell line, were employed to examine the impact of LRP6 knockdown on proliferation, apoptosis, and migration, as well as invasion and tube formation...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29437009/the-bhlh-protein-nulp1-is-essential-for-femur-development-via-acting-as-a-cofactor-in-wnt-signaling-in-drosophila
#10
Q Zeng, Y Wan, P Zhu, M Zhao, F Jiang, J Chen, M Tang, X Zhu, Y Li, H Zha, Y Wang, M Hu, X Mo, Y Zhang, Y Deng, Y Chen, X Fan, Y Chen, X Ye, R Bodmer, K Ocorr, Z Jiang, J Zhuang, W Yuan, X Wu
The basic helix-loop-helix (bHLH) protein families are a large class of transcription factors, which are associated with cell proliferation, tissue differentiation, and other important development process. We reported that the Nuclear localized protein-1 (Nulp1) might act as a novel bHLH transcriptional factor to mediate cellular functions. However, its role in development in vivo remains unknown. Here we show that Drosophila Nulp1 (dNulp1) mutants, generated by CRISPR/Cas9 targeting the Domain of Unknown Function (DUF654) in its C terminal, are partially homozygous lethal and the rare escapers have bent femurs, which are similar to the major manifestation of congenital bent-bone dysplasia in human Stuve-Weidemann syndrome...
February 12, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29435407/bmp3-expression-by-osteoblast-lineage-cells-is-regulated-by-canonical-wnt-signaling
#11
Shoichiro Kokabu, Vicki Rosen
Bone morphogenetic protein (BMP) and canonical Wnt (cWnt) signaling factors are both known to regulate bone mass, fracture risk, fracture repair, and osteoblastogenesis. BMP3 is the most abundant BMP and negatively regulates osteoblastogenesis and bone mass. Thus, identifying the mechanism by which BMP3 acts to depress bone formation may allow for the development of new therapeutics useful in the treatment for osteopenia and osteoporosis. Here, we report that cWnt signaling stimulates BMP3 expression in osteoblast (OB) lineage cells...
February 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29435196/exon-3-mutations-of-ctnnb1-drive-tumorigenesis-a-review
#12
REVIEW
Chao Gao, Yingmei Wang, Russell Broaddus, Longhao Sun, Fengxia Xue, Wei Zhang
The canonical Wnt/β-catenin signaling pathway, an important modulator of progenitor cell proliferation and differentiation, is highly regulated for the maintenance of critical biological homeostasis. Decades of studies in cancer genetics and genomics have demonstrated that multiple genes encoding key proteins in this signaling pathway serve as targets for recurrent mutational alterations. Among these proteins, β-catenin and adenomatosis polyposis coli (APC) are two key nodes. β-catenin contributes in transporting extracellular signals for nuclear programming...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435081/long-non-coding-rna-ccat2-promotes-epithelial-mesenchymal-transition-involving-wnt-%C3%AE-catenin-pathway-in-epithelial-ovarian-carcinoma-cells
#13
Beidi Wang, Meimei Liu, Rujin Zhuang, Jing Jiang, Jiayin Gao, Hao Wang, He Chen, Zongfeng Zhang, Ye Kuang, Peiling Li
Long non-coding RNA colon cancer-associated transcript 2 (CCAT2) is dysregulated in a variety of types of human cancer. However, the role of CCAT2 in epithelial ovarian carcinoma (EOC) remains largely unknown. The aim of this study is to investigate the effect of CCAT2 on epithelial-mesenchymal transition (EMT) and related molecular mechanisms in epithelial ovarian cancer cells. In the current paper, we found that CCAT2 was significantly upregulated in EOC SKOV3, A2780 and HO8910 cell lines compared with the normal ovarian epithelial HUM-CELL-0088 cell line...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29435043/wnt3a-expression-is-associated-with-poor-prognosis-of-esophageal-squamous-cell-carcinoma
#14
Junya Oguma, Soji Ozawa, Akihito Kazuno, Miho Nitta, Yamato Ninomiya, Hiroshi Kajiwara
The Wnt signaling pathway is widely implicated in various types of cancer. Canonical Wnt signaling, including Wnt3a, may be a key component of cancer progression or chemoresistance. Consequently, it was hypothesized that Wnt3a expression may be a prognostic factor of esophageal squamous cell carcinoma (ESCC) due to its roles in chemoresistance and tumor progression. The aim of the present study was to investigate the association between Wnt3a expression and prognosis in patients with ESCC. Wnt3a expression was evaluated in resected specimens from 139 patients with thoracic ESCC who were subjected to curative surgery without neoadjuvant therapy in Tokai University Hospital between 2007 and 2009...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29429993/the-non-canonical-wnt-pathway-leads-to-aged-dendritic-cell-differentiation
#15
Haibo Zhou, Li Wu
No abstract text is available yet for this article.
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29428231/bcl9-upregulation-in-adrenocortical-carcinoma-a-novel-wnt-%C3%AE-catenin-activating-event-driving-adrenocortical-malignancy
#16
Taylor C Brown, Norman G Nicolson, Reju Korah, Tobias Carling
BACKGROUND: B-Cell CLL/Lymphoma 9 (BCL9) is a recently described oncogene that promotes tumorigenesis via activation of the Wnt/β-Catenin signaling cascade. Though constitutively active Wnt/β-Catenin signaling is a molecular hallmark of adrenocortical carcinoma (ACC), a potential role for BCL9 to promote Wnt/β-Catenin pathway dysregulation in adrenocortical tumorigenesis remains to be elucidated. STUDY DESIGN: This study involved a retrospective analysis at a tertiary academic referral center of 27 patients with adrenocortical tumors, including in vitro investigation of BCL9...
February 8, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29427622/secreted-agr2-promotes-invasion-of-colorectal-cancer-cells-via-wnt11-mediated-non-canonical-wnt-signaling
#17
Shaobo Tian, Jia Hu, Kaixiong Tao, Jian Wang, Yanan Chu, Jing Li, Zhibo Liu, Xueliang Ding, Luming Xu, Qilin Li, Ming Cai, Jinbo Gao, Xiaoming Shuai, Guobin Wang, Lin Wang, Zheng Wang
Human anterior gradient-2 (AGR2), a member of protein disulfide isomerase (PDI) family, is present in both intracellular and extracellular compartments. Although AGR2 is overexpressed in various human cancers and reported to promote aggressive tumor features, little is known regarding AGR2's extracellular functions during tumorigenesis. Here, we demonstrate that secreted AGR2 promotes cell migration and metastasis of colorectal cancer (CRC) in vitro and in vivo. Mechanistically, secreted AGR2 elevated Wnt11 expression, triggering non-canonical Wnt signaling: the Ca2+/Calmodulin-dependent protein kinase II (CaMKII) and c-jun amino-terminal kinase (JNK) pathways...
February 7, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29426949/pp5-ppp5c-is-a-phosphatase-of-dvl2
#18
Jianlei Xie, Meng Han, Miaojun Zhang, Haiteng Deng, Wei Wu
Dishevelled (Dvl) family proteins are key mediators of Wnt signalling and function in both canonical and noncanonical branches. Dvl2, the most studied Dvl protein, is extensively regulated by phosphorylation. Several kinases were found to be critical for Dvl2 localisation, stability control and functional segregation. For example, S143-phosphorylated Dvl2 was detected, together with CK1δ/ε, at the centrosome and basal body of primary cilia and plays pivotal roles during ciliogenesis. However, relatively less is known about Dvl dephosphorylation and the phosphatases involved...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29423029/recombinant-frizzled1-protein-attenuated-cardiac-hypertrophy-after-myocardial-infarction-via-the-canonical-wnt-signaling-pathway
#19
Jingjing Fan, Lin Qiu, Hongyang Shu, Ben Ma, Marco Hagenmueller, Johannes H Riffel, Soeren Meryer, Min Zhang, Stefan E Hardt, Lin Wang, Dao Wen Wang, Hongyu Qiu, Ning Zhou
Postinfarct cardiac hypertrophy is an independent risk factor for heart failure and sudden death. Regression of cardiac hypertrophy has emerged as a promising strategy in the treatment of myocardial infarction (MI). Here we hypothesized that frizzled1 (FZD1), a receptor of the canonical Wnt signaling pathway, is a novel mediator of ischemia-associated cardiac hypertrophy. MI was induced in mice by left anterior descending (LAD) coronary occlusion. One week after MI, the expression of FZD1 was found to be notably increased in the left ventricles (LVs) of the MI-mice compared to shams...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415892/inhibition-of-wnt-%C3%AE-catenin-signaling-ameliorates-osteoarthritis-in-a-murine-model-of-experimental-osteoarthritis
#20
Caressa Lietman, Brian Wu, Sarah Lechner, Andrew Shinar, Madhur Sehgal, Evgeny Rossomacha, Poulami Datta, Anirudh Sharma, Rajiv Gandhi, Mohit Kapoor, Pampee P Young
Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium. The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important regulator of tissue repair and fibrosis. This study seeks to examine Wnt pathway effects on synovial fibroblasts and articular chondrocytes as well as the therapeutic effects of Wnt inhibition on OA disease severity. Mice underwent destabilization of the medial meniscus surgery and were treated by intra-articular injection with XAV-939, a small-molecule inhibitor of Wnt/β-catenin signaling...
February 8, 2018: JCI Insight
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