keyword
https://read.qxmd.com/read/37741450/spermidine-suppresses-oral-carcinogenesis-through-autophagy-induction-dna-damage-repair-and-oxidative-stress-reduction
#21
JOURNAL ARTICLE
Fernanda Borchers Coeli-Lacchini, Gabriel da Silva, Monica Belentani, Jovelina Samara Ferreira Alves, Tatiane Resende Ushida, Glauce Trevisan Lunardelli, Cristiana Bernadelli Garcia, Tarcília Aparecida Silva, Norberto Peporine Lopes, Andréia Machado Leopoldino
In cancer, autophagy has been proposed to play a dual role. In this study, we investigated the role of autophagy in oral carcinogenesis using the model of oral squamous cell carcinoma (OSCC) induced by carcinogen 4-nitroquinoline 1-oxide (4NQO), mimicking molecular and histopathologic aspects of human OSCC. The induction of autophagy by spermidine (SPD) treatment reduced the severity of lesions and the incidence of OSCC in mice exposed to 4NQO. On the other hand, autophagy inhibition by chloroquine treatment had no protection...
September 21, 2023: American Journal of Pathology
https://read.qxmd.com/read/37741047/decreased-plasma-levels-of-sphingolipids-and-total-cholesterol-in-adult-cystic-fibrosis-patients
#22
JOURNAL ARTICLE
Dilara Bal Topcu, Berrin Er, Filiz Ozcan, Mutay Aslan, Lutfi Coplu, Incilay Lay, Yesim Oztas
BACKGROUND: Sphingolipid species in the lung epithelium have a critical role for continuity of membrane structure, vesicular transport, and cell survival. Sphingolipid species were reported to have a role in the inflammatory etiology of cystic fibrosis by previous work. The aim of the study was to investigate the levels of plasma sphingomyelin and ceramide in adult cystic fibrosis (CF) patients and compared with healthy controls. MATERIALS AND METHODS: Blood samples were obtained from CF patients at exacerbation (n = 15), discharge (n = 13) and stable periods (n = 11)...
September 16, 2023: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://read.qxmd.com/read/37736098/immunometabolic-capacities-of-nutritional-fatty-acids-in-regulation-of-inflammatory-bone-cell-interaction-and-systemic-impact-of-periodontal-infection
#23
JOURNAL ARTICLE
Annika Döding, Svenja Zimmermann, Ahmed Maghames, Michael Reimann, Judit Symmank, Maria Thürmer, Markus H Gräler, Michael Wolf, Collin Jacobs, Andreas Koeberle, Bernd Sigusch, Ulrike Schulze-Späte
INTRODUCTION: Novel preventive strategies in periodontal disease target the bacterial-induced inflammatory host response to reduce associated tissue destruction. Strategies focus on the modulation of tissue-destroying inflammatory host response, particularly the reduction of inflammation and promotion of resolution. Thereby, nutrition is a potent immunometabolic non-pharmacological intervention. Human studies have demonstrated the benefit of olive oil-containing Mediterranean-style diets (MDs), the main component of which being mono-unsaturated fatty acid (FA) oleic acid (OA (C18:1))...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37734910/disruption-of-cers6-mediated-sphingolipid-metabolism-by-fto-deficiency-aggravates-ulcerative-colitis
#24
JOURNAL ARTICLE
Yanru Ma, Xinyu Zhang, Baoqin Xuan, Danjie Li, Nan Yin, Lijun Ning, Yi-Lu Zhou, Yuqing Yan, Tianying Tong, Xiaoqiang Zhu, Xiaowen Huang, Muni Hu, Zhenhua Wang, Zhe Cui, Huabin Li, Jiqiu Wang, Jing-Yuan Fang, Ruixin Liu, Haoyan Chen, Jie Hong
BACKGROUND AND AIMS: Deregulation of RNA N6-methyladenosine (m6 A) modification in intestinal epithelial cells (IECs) influences intestinal immune cells and leads to intestinal inflammation. We studied the function of fat mass-and obesity-associated protein (FTO), one of the m6 A demethylases, in patients with ulcerative colitis (UC). METHODS: We analysed colon tissues of Ftoflox/flox ; Villin-cre mice and their Ftoflox/flox littermates with dextran sulfate sodium (DSS) using real-time PCR and 16s rRNA sequencing...
January 5, 2024: Gut
https://read.qxmd.com/read/37714377/ceramide-synthase-6-cers6-is-upregulated-in-alcohol-associated-liver-disease-and-exhibits-sex-based-differences-in-the-regulation-of-energy-homeostasis-and-lipid-droplet-accumulation
#25
JOURNAL ARTICLE
Sookyoung Jeon, Eleonora Scorletti, Joseph Dempsey, Delfin Buyco, Chelsea Lin, Yedidya Saiman, Susovon Bayen, Julia Harkin, Jasmin Martin, Royce Hooks, Besim Ogretmen, Josepmaria Argemi, Luma Melo, Ramon Bataller, Rotonya M Carr
OBJECTIVE: Alcohol-associated liver disease (ALD) is the leading cause of liver-related mortality worldwide. Current strategies to manage ALD focus largely on advanced stage disease, however, metabolic changes such as glucose intolerance are apparent at the earliest stage of alcoholic steatosis and increase the risk of disease progression. Ceramides impair insulin signaling and accumulate in ALD, and metabolic pathways involving ceramide synthase 6 (CerS6) are perturbed in ALD during hepatic steatosis...
September 14, 2023: Molecular Metabolism
https://read.qxmd.com/read/37579172/ceramide-as-an-endothelial-cell-surface-receptor-and-a-lung-specific-lipid-vascular-target-for-circulating-ligands
#26
JOURNAL ARTICLE
Daniela I Staquicini, Marina Cardó-Vila, Jimmy A Rotolo, Fernanda I Staquicini, Fenny H F Tang, Tracey L Smith, Aditya Ganju, Carmine Schiavone, Prashant Dogra, Zhihui Wang, Vittorio Cristini, Ricardo J Giordano, Michael G Ozawa, Wouter H P Driessen, Bettina Proneth, Glauco R Souza, Lina M Brinker, Achraf Noureddine, Ashley J Snider, Daniel Canals, Juri G Gelovani, Irina Petrache, Rubin M Tuder, Lina M Obeid, Yusuf A Hannun, Richard N Kolesnick, C Jeffrey Brinker, Renata Pasqualini, Wadih Arap
The vascular endothelium from individual organs is functionally specialized, and it displays a unique set of accessible molecular targets. These serve as endothelial cell receptors to affinity ligands. To date, all identified vascular receptors have been proteins. Here, we show that an endothelial lung-homing peptide (CGSPGWVRC) interacts with C16-ceramide, a bioactive sphingolipid that mediates several biological functions. Upon binding to cell surfaces, CGSPGWVRC triggers ceramide-rich platform formation, activates acid sphingomyelinase and ceramide production, without the associated downstream apoptotic signaling...
August 22, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/37557964/metabolomic-profiles-of-chronic-distress-are-associated-with-cardiovascular-disease-risk-and-inflammation-related-risk-factors
#27
JOURNAL ARTICLE
Raji Balasubramanian, Katherine H Shutta, Marta Guasch-Ferre, Tianyi Huang, Shaili C Jha, Yiwen Zhu, Aladdin H Shadyab, JoAnn E Manson, Dolores Corella, Montserrat Fitó, Frank B Hu, Kathryn M Rexrode, Clary B Clish, Susan E Hankinson, Laura D Kubzansky
BACKGROUND: Chronic psychological distress is associated with increased risk of cardiovascular disease (CVD) and investigators have posited inflammatory factors may be centrally involved in these relationships. However, mechanistic evidence and molecular underpinnings of these processes remain unclear, and data are particularly sparse among women. This study examined if a metabolite profile linked with distress would be associated with increased CVD risk and inflammation-related risk factors...
August 7, 2023: Brain, Behavior, and Immunity
https://read.qxmd.com/read/37446046/diverse-sphingolipid-profiles-in-rectal-and-colon-cancer
#28
JOURNAL ARTICLE
Adam R Markowski, Agnieszka U Błachnio-Zabielska, Karolina Pogodzińska, Anna J Markowska, Piotr Zabielski
Colorectal cancer is a heterogenous group of neoplasms showing a variety of clinical and pathological features depending on their anatomical location. Sphingolipids are involved in the formation and progression of cancers, and their changes are an important part of the abnormalities observed during carcinogenesis. Because the course of rectal and colonic cancer differs, the aim of the study was to assess whether the sphingolipid profile is also different in tumors of these two regions. Using a combination of ultra-high-performance liquid chromatography combined with triple quadrupole mass spectrometry, differences in the amounts of cellular sphingolipids were found in colorectal cancer...
June 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37420217/autologous-hematopoietic-stem-cell-transplantation-significantly-alters-circulating-ceramides-in-peripheral-blood-of-relapsing-remitting-multiple-sclerosis-patients
#29
JOURNAL ARTICLE
Aina Vaivade, Anna Wiberg, Payam Emami Khoonsari, Henrik Carlsson, Stephanie Herman, Asma Al-Grety, Eva Freyhult, Ulla Olsson-Strömberg, Joachim Burman, Kim Kultima
BACKGROUND: The common inflammatory disease multiple sclerosis (MS) is a disease of the central nervous system. For more than 25 years autologous hematopoietic stem cell transplantation (AHSCT) has been used to treat MS. It has been shown to be highly effective in suppressing inflammatory activity in relapsing-remitting MS (RRMS) patients. This treatment is thought to lead to an immune system reset, inducing a new, more tolerant system; however, the precise mechanism behind the treatment effect in MS patients is unknown...
July 7, 2023: Lipids in Health and Disease
https://read.qxmd.com/read/37345118/lasp1-cers6-and-actin-form-a-ternary-complex-that-promotes-cancer-cell-migration
#30
JOURNAL ARTICLE
Atsuko Niimi, Siripan Limsirichaikul, Keiko Kano, Yasuyoshi Mizutani, Toshiyuki Takeuchi, Patinya Sawangsri, Dat Quoc Tran, Yoshiyuki Kawamoto, Motoshi Suzuki
CERS6 is associated with metastasis and poor prognosis in non-small cell lung cancer (NSCLC) patients through d18:1/C16:0 ceramide (C16 ceramide)-mediated cell migration, though the detailed mechanism has not been elucidated. In the present study, examinations including co-immunoprecipitation, liquid chromatography, and tandem mass spectrometry analysis were performed to identify a novel binding partner of CERS6. Among the examined candidates, LASP1 was a top-ranked binding partner, with the LIM domain possibly required for direct interaction...
May 16, 2023: Cancers
https://read.qxmd.com/read/37340831/an-exploratory-study-of-plasma-ceramides-in-comorbidities-in-down-syndrome
#31
JOURNAL ARTICLE
Gordon Worley, Seul Kee Byeon, P Brian Smith, Sarah J Hart, Sarah P Young, Akhilesh Pandey, Priya S Kishnani
Plasma ceramide levels (henceforth, "ceramides") are biomarkers of some diseases that are comorbidities of Down syndrome (DS). We sought to determine if comorbidities in DS were associated with ceramides, studying a convenience cohort of 35 study participants, all ≥12 months old. To identify comorbidities, we reviewed the problem lists in electronic health records that were concurrent with sample collection. We placed clinically related comorbidities into one of five categories of comorbidities, henceforth, categories: obesity/overweight; autoimmune disease; congenital heart disease; bacterial infection; and central nervous system (CNS) condition...
June 21, 2023: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/37335416/solid-tumor-treatment-via-augmentation-of-bioactive-c6-ceramide-levels-with-thermally-ablative-focused-ultrasound
#32
JOURNAL ARTICLE
E Andrew Thim, Todd Fox, Tye Deering, Luke R Vass, Natasha D Sheybani, Mark Kester, Richard J Price
Sparse scan partial thermal ablation (TA) with focused ultrasound (FUS) may be deployed to treat solid tumors and increase delivery of systemically administered therapeutics. Furthermore, C6-ceramide-loaded nanoliposomes (CNLs), which rely upon the enhanced-permeation and retention (EPR) effect for delivery, have shown promise for treating solid tumors and are being tested in clinical trials. Here, our objective was to determine whether CNLs synergize with TA in the control of 4T1 breast tumors. CNL monotherapy of 4T1 tumors yielded significant intratumoral bioactive C6 accumulation by the EPR effect, but tumor growth was not controlled...
June 19, 2023: Drug Delivery and Translational Research
https://read.qxmd.com/read/37234408/alkaline-ceramidase-clac-inhibition-enhances-heat-stress-response-in-cyrtorhinus-lividipennis-reuter
#33
JOURNAL ARTICLE
Min Chen, Xiao-Xiao Shi, Ni Wang, Chao Zhang, Zhe-Yi Shi, Wen-Wu Zhou, Zeng-Rong Zhu
Ceramidases (CDases) are vital sphingolipid enzymes involved in organismal growth and development. They have been reported as key mediators of thermal stress response. However, whether and how CDase responds to heat stress in insects remain unclear. Herein, we identified two CDase genes, C. lividipennis alkaline ceramidase ( ClAC ) and neutral ceramidase ( ClNC ), by searching the transcriptome and genome databases of the mirid bug, Cyrtorhinus lividipennis , an important natural predator of planthoppers. Quantitative PCR (qPCR) analysis showed that both ClNC and ClAC were highly expressed in nymphs than in adults...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37212278/marked-elevations-in-lung-and-plasma-ceramide-in-covid-19-linked-to-microvascular-injury
#34
JOURNAL ARTICLE
Irina Petrache, Elisabet Pujadas, Aditya Ganju, Karina A Serban, Alexander Borowiec, Beatrice Babbs, Irina A Bronova, Nicholas Egersdorf, Patrick S Hume, Khushboo Goel, William J Janssen, Evgeny V Berdyshev, Carlos Cordon-Cardo, Richard Kolesnick
The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear. Implicated in the pathophysiology of diverse diseases characterized by endothelial damage, including ARDS and ischemic cardiovascular disease, ceramide and in particular palmitoyl ceramide (C16:0-ceramide) may be involved in the microvascular injury in COVID-19. Using deidentified plasma and lung samples from COVID-19 patients, ceramide profiling by mass spectrometry was performed...
May 22, 2023: JCI Insight
https://read.qxmd.com/read/37209771/metabolism-of-sphingadiene-and-characterization-of-the-sphingadiene-producing-enzyme-fads3
#35
JOURNAL ARTICLE
Keisuke Jojima, Akio Kihara
Of the long-chain bases (LCBs) that comprise the ceramides (CERs) present in mammals, only 4,14-sphingadiene (sphingadiene; SPD) has a cis double bond (at C14). Because of this unique structure, the metabolism of SPD may differ from that of other LCBs, but whether this is the case remains unclear. FADS3 is responsible for introducing the cis double bond in SPD. However, the substrate specificity of FADS3 and cofactors involved in the FADS3-catalyzed reaction are also unknown. In the present study, a cell-based assay using a ceramide synthase inhibitor and an in vitro experiment showed that FADS3 is active toward sphingosine (SPH)-containing CERs (SPH-CERs) but not toward free SPH...
May 18, 2023: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
https://read.qxmd.com/read/37189799/covid-19-blood-lipid-changes-and-thrombosis
#36
REVIEW
Akhlaq A Farooqui, Tahira Farooqui, Grace Y Sun, Teng-Nan Lin, Daniel B L Teh, Wei-Yi Ong
Although there is increasing evidence that oxidative stress and inflammation induced by COVID-19 may contribute to increased risk and severity of thromboses, the underlying mechanism(s) remain to be understood. The purpose of this review is to highlight the role of blood lipids in association with thrombosis events observed in COVID-19 patients. Among different types of phospholipases A2 that target cell membrane phospholipids, there is increasing focus on the inflammatory secretory phospholipase A2 IIA (sPLA2 -IIA), which is associated with the severity of COVID-19...
April 15, 2023: Biomedicines
https://read.qxmd.com/read/37164358/association-of-healthy-dietary-patterns-and-cardiorespiratory-fitness-in-the-community
#37
JOURNAL ARTICLE
Michael Y Mi, Priya Gajjar, Maura E Walker, Patricia Miller, Vanessa Xanthakis, Venkatesh L Murthy, Martin G Larson, Ramachandran S Vasan, Ravi V Shah, Gregory D Lewis, Matthew Nayor
AIMS: To evaluate the associations of dietary indices and quantitative cardiorespiratory fitness (CRF) measures in a large, community-based sample harnessing metabolomic profiling to interrogate shared biology. METHODS AND RESULTS: Framingham Heart Study (FHS) participants underwent maximum effort cardiopulmonary exercise tests for CRF quantification (via peak VO2) and completed semi-quantitative food frequency questionnaires. Dietary quality was assessed by the Alternative Healthy Eating Index (AHEI) and Mediterranean-style Diet Score (MDS), and fasting blood concentrations of 201 metabolites were quantified...
October 10, 2023: European Journal of Preventive Cardiology
https://read.qxmd.com/read/37158660/plasma-c18-0-ceramide-is-a-novel-potential-biomarker-for-disease-severity-in-myasthenia-gravis
#38
JOURNAL ARTICLE
Zhouao Zhang, Xiaoyu Huang, Xue Du, Zhouyi Wang, Yingying Wang, Mingming Xu, Xiao Chen, Qian Yao, Lisha Yan, Yong Zhang
Myasthenia gravis (MG) is an antibody-mediated autoimmune disorder characterized by fluctuation of fatigue and weakness of muscle. Due to the heterogeneity of the course of MG, available biomarkers for prognostic prediction are urgently needed. Ceramide (Cer) was reported to participate in immune regulation and many autoimmune diseases, but its effects on MG remain undefined. This study aimed to investigate the ceramides expression levels in MG patients and their potential as novel biomarkers of disease severity...
May 9, 2023: Journal of Neurochemistry
https://read.qxmd.com/read/37108361/the-effect-of-silencing-the-genes-responsible-for-the-level-of-sphingosine-1-phosphate-on-the-apoptosis-of-colon-cancer-cells
#39
JOURNAL ARTICLE
Adam R Markowski, Arkadiusz Żbikowski, Piotr Zabielski, Urszula Chlabicz, Patrycja Sadowska, Karolina Pogodzińska, Agnieszka U Błachnio-Zabielska
Sphingosine-1-phosphate (S1P) and ceramides (Cer) are engaged in key events of signal transduction, but their involvement in the pathogenesis of colorectal cancer is not conclusive. The aim of our study was to investigate how the modulation of sphingolipid metabolism through the silencing of the genes involved in the formation ( SPHK1 ) and degradation ( SGPL1 ) of sphingosine-1-phosphate would affect the sphingolipid profile and apoptosis of HCT-116 human colorectal cancer cells. Silencing of SPHK1 expression decreased S1P content in HCT-116 cells, which was accompanied by an elevation in sphingosine, C18:0-Cer, and C18:1-Cer, increase in the expression and activation of Caspase-3 and -9, and augmentation of apoptosis...
April 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37081501/long-and-very-long-chain-ceramides-are-predictors-of-acute-kidney-injury-in-patients-with-acute-coronary-syndrome-the-peacp-study
#40
JOURNAL ARTICLE
Lianjing Liang, Dongze Li, Rui Zeng, Haihong Zhang, Lin Lv, Wei Wei, Zhi Wan
BACKGROUND: Acute kidney injury (AKI) can be caused by multiple factors/events, including acute coronary syndrome (ACS). Ceramides are involved in atherosclerosis progression, cardiovascular events, and renal damage. Almost no studies have been conducted on the relationship between ceramide concentrations and AKI events. Therefore, we evaluated the association between plasma ceramide level at admission and AKI in patients with ACS undergoing percutaneous coronary intervention. METHODS: We enrolled 842 ACS patients from the Prospective Multicenter Study for Early Evaluation of Acute Chest Pain...
April 20, 2023: Cardiovascular Diabetology
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