keyword
https://read.qxmd.com/read/38488360/lipidomics-reveals-the-significance-and-mechanism-of-the-cellular-ceramide-metabolism-for-rotavirus-replication
#1
JOURNAL ARTICLE
Ran Tao, Xi Cheng, Laqiang Gu, Jinzhu Zhou, Xuejiao Zhu, Xuehan Zhang, Rongli Guo, Wei Wang, Bin Li
As one of the most important causative agents of severe gastroenteritis in children, piglets, and other young animals, species A rotaviruses have adversely impacted both human health and the global swine industry. Vaccines against rotaviruses (RVs) are insufficiently effective, and no specific treatment is available. To understand the relationships between porcine RV (PoRV) infection and enterocytes in terms of the cellular lipid metabolism, we performed an untargeted liquid chromatography mass spectrometry (LC-MS) lipidomics analysis of PoRV-infected IPEC-J2 cells...
March 15, 2024: Journal of Virology
https://read.qxmd.com/read/38431645/the-effects-of-restraint-stress-on-ceramide-metabolism-disorders-in-the-rat-liver-the-role-of-cers6-in-hepatocyte-injury
#2
JOURNAL ARTICLE
Yichang Liu, Zhaoling Sun, Qiuli Sun, Li Wang, Chuan Wang, Yingmin Li, Chunling Ma, Weibo Shi, Guozhong Zhang, Yiming Dong, Xiaojing Zhang, Bin Cong
BACKGROUND: Stress is implicated in various pathological conditions leading to liver injury. Existing evidence suggests that excessive stress can induce mitochondrial damage in hepatocytes, yet the underlying mechanism remains unclear. Ceramide synthase 6 (CerS6)-derived C16:0 ceramide is recognised as a lipotoxic substance capable of causing mitochondrial damage. However, the role of CerS6 in stress has received insufficient attention. This study aimed to explore the involvement of CerS6 in stress-induced hepatic damage and its associated mechanisms...
March 2, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38430210/docosahexaenoic-acid-modulates-nonalcoholic-fatty-liver-disease-by-suppressing-endocannabinoid-system
#3
JOURNAL ARTICLE
Yan-Fang Chen, Ze-Kai Fan, Yin-Peng Wang, Peng Liu, Xiao-Fei Guo, Duo Li
SCOPE: Endocannabinoid signaling regulates energy homeostasis, and is tightly associated with nonalcoholic fatty liver disease (NAFLD). The study previously finds that supplementation of docosahexaenoic acid (DHA) has superior function to ameliorate NAFLD compared with eicosapentaenoic acid (EPA), however, the underlying mechanism remains elusive. The present study aims to investigate whether DHA intervention alleviates NAFLD via endocannabinoid system. METHODS AND RESULTS: In a case-control study, the serum endocannabinoid ligands in 60 NAFLD and 60 healthy subjects are measured...
March 2, 2024: Molecular Nutrition & Food Research
https://read.qxmd.com/read/38415528/secretion-of-sphinganine-by-drug-induced-cancer-cells-and-modified-mimetic-sphinganine-mms-as-c-src-kinase-inhibitor
#4
JOURNAL ARTICLE
Raskia Nandangiri, Seethamma T N, Ajay Kumar Raj, Kiran B Lokhande, Kratika Khunteta, Ameya Hebale, Haet Kothari, Vaidehi Patel, Sachin C Sarode, Nilesh Kumar Sharma
BACKGROUND: Cancer cells exhibit selective metabolic reprogramming to promote proliferation, invasiveness, and metastasis. Sphingolipids such as sphingosine and sphinganine have been reported to modulate cell death processes in cancer cells. However, the potential of extracellular sphinganine and its mimetic compounds as inducers of cancer cell death has not been thoroughly investigated. METHODS: We obtained extracellular conditioned medium from HCT-116 cells treated with the previously reported anticancer composition, goat urine DMSO fraction (GUDF)...
February 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38342586/the-association-between-c24-0-c16-0-ceramide-ratio-and-cardiorespiratory-fitness-is-robust-to-effect-modifications-by-age-and-sex
#5
JOURNAL ARTICLE
Jule Zatloukal, Stephanie Zylla, Marcello R P Markus, Ralf Ewert, Sven Gläser, Henry Völzke, Diana Albrecht, Nele Friedrich, Matthias Nauck, Linda R Peterson, Xuntian Jiang, Jean E Schaffer, Stephan B Felix, Marcus Dörr, Martin Bahls, Stefan Gross
Ceramides and cardiorespiratory (CR) fitness are both related to cardiovascular diseases. The associations of three blood plasma ceramides (C16:0, C22:0, and C24:0) with CR fitness in the population-based Study of Health in Pomerania (SHIP-START-1; n = 1,102; mean age 50.3 years, 51.5% women) are investigated. In addition, subgroup analysis according to age (</≥54 years) and sex (female/male) is performed. Ceramides are quantified by liquid chromatography/mass spectrometry (LC/MS). CR fitness is assessed by a cardiopulmonary exercise test...
February 11, 2024: Advanced biology
https://read.qxmd.com/read/38275624/dysregulation-of-ceramide-metabolism-is-linked-to-iron-deposition-and-activation-of-related-pathways-in-the-aorta-of-atherosclerotic-miniature-pigs
#6
JOURNAL ARTICLE
Zhaowei Cai, Liqun Deng, Yingying Fan, Yujie Ren, Yun Ling, Jue Tu, Yueqin Cai, Xiaoping Xu, Minli Chen
The miniature pig is a suitable animal model for investigating human cardiovascular diseases. Nevertheless, the alterations in lipid metabolism within atherosclerotic plaques of miniature pigs, along with the underlying mechanisms, remain to be comprehensively elucidated. In this study, we aim to examine the alterations in lipid composition and associated pathways in the abdominal aorta of atherosclerotic pigs induced by a high-fat, high-cholesterol, and high-fructose (HFCF) diet using lipidomics and RNA-Seq methods...
December 19, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38273290/circulating-metabolic-profile-in-idiopathic-pulmonary-fibrosis-data-from-the-ipf-pro-registry
#7
JOURNAL ARTICLE
Ross Summer, Jamie L Todd, Megan L Neely, L Jason Lobo, Andrew Namen, L Kristin Newby, Shirin Shafazand, Sally Suliman, Christian Hesslinger, Sascha Keller, Thomas B Leonard, Scott M Palmer, Olga Ilkayeva, Michael J Muehlbauer, Christopher B Newgard, Jesse Roman
BACKGROUND: The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis (IPF). We evaluated whether circulating levels of metabolites correlate with the presence of IPF, with the severity of IPF, or with the risk of clinically relevant outcomes among patients with IPF. METHODS: We analyzed enrollment plasma samples from 300 patients with IPF in the IPF-PRO Registry and 100 individuals without known lung disease using a set of targeted metabolomics and clinical analyte modules...
January 25, 2024: Respiratory Research
https://read.qxmd.com/read/38255295/circulating-lipoprotein-sphingolipids-in-chronic-kidney-disease-with-and-without-diabetes
#8
JOURNAL ARTICLE
Maria F Lopes-Virella, Samar M Hammad, Nathaniel L Baker, Richard L Klein, Kelly J Hunt
Abnormalities of sphingolipid metabolism play an important role in diabetes. We compared sphingolipid levels in plasma and in isolated lipoproteins between healthy control subjects and two groups of patients, one with chronic kidney disease without diabetes (ND-CKD), and the other with type 2 diabetes and macroalbuminuria (D-MA). Ceramides, sphingomyelins, and sphingoid bases and their phosphates in LDL were higher in ND-CKD and in D-MA patients compared to controls. However, ceramides and sphingoid bases in HDL2 and HDL3 were lower in ND-CKD and in D-MA patients than in controls...
January 15, 2024: Biomedicines
https://read.qxmd.com/read/38244710/identification-of-cers5-as-a-molecular-biomarker-in-pan-cancer-through-multiple-omics-integrative-analysis
#9
JOURNAL ARTICLE
Shengyu Wang, Jian Yang, Weijia Huang, Zhu Yu, Yuantian Mao, Yue Feng, Junqiang Chen
Cancer is a devastating disease that presents a major threat to human health. The protein CERS5 is responsible for synthesizing C16-ceramide, but its role in cancer is poorly understood. In this study, we examined the connection between CERS5 expression and pan-cancer prognosis, diagnosis, and the molecular mechanism involved. Kaplan-Meier survival analysis revealed variations among different cancer types. Functional enrichment analysis was conducted using gene set enrichment analysis (GSEA), and a network of protein-protein interaction (PPI) was constructed...
January 18, 2024: Cellular Signalling
https://read.qxmd.com/read/38182433/development-of-an-lc-ms-ms-method-to-measure-sphingolipids-in-csf-from-patients-with-multiple-sclerosis
#10
JOURNAL ARTICLE
Yadira X Perez-Paramo, Dawn Dufield, Rathna Veeramachaneni, Emily Parkhurst, Christopher Harp, Akshaya Ramesh, Ryan C Winger, Anne H Cross, Jeffrey M Gelfand, Amit Bar-Or, W Rodney Mathews, Veronica G Anania
Multiple sclerosis is an inflammatory and degenerative disease characterized by different clinical courses including relapsing multiple sclerosis (RMS) and primary-progressive-multiple sclerosis (PPMS). A hallmark of patients with multiple sclerosis(pwMS) includes a putative autoimmune response, which results in demyelination and neuroaxonal damage in the central nervous system. Sphingolipids in cerebrospinal fluid (CSF) have been proposed as potential biomarkers reflective of disease activity in pwMS. Hence, sensitive methods to accurately quantify sphingolipids in CSF are needed...
January 5, 2024: Molecular Pharmacology
https://read.qxmd.com/read/38161124/associations-of-plasma-sphingolipids-with-measures-of-insulin-sensitivity-%C3%AE-cell-function-and-incident-diabetes-in-japanese-americans
#11
JOURNAL ARTICLE
Ji Cheol Bae, Pandora L Wander, Rozenn N Lemaitre, Amanda M Fretts, Colleen M Sitlani, Hai H Bui, Melissa K Thomas, Donna Leonetti, Wilfred Y Fujimoto, Edward J Boyko, Kristina M Utzschneider
BACKGROUND AND AIMS: To prospectively investigate associations of plasma sphingolipids with insulin sensitivity, β-cell function, and incident diabetes in the Japanese American Community Diabetes Study. METHODS AND RESULTS: Baseline plasma samples from adults without diabetes (n = 349; mean age 56.7 years, 51 % men) were assayed for circulating ceramide and sphingomyelin species. Adjusted regression models examined cross-sectional and longitudinal associations with insulin sensitivity (HOMA2-%S), β-cell function (oral disposition index: DIo) and with incident diabetes over 5 years follow-up...
October 29, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/38077163/ceramides-in-peripheral-arterial-plaque-lead-to-endothelial-cell-dysfunction
#12
JOURNAL ARTICLE
Rodrigo Meade, Yang Chao, Nikolai Harroun, Chenglong Li, Shahab Hafezi, Fong-Fu Hsu, Clay F Semenkovich, Mohamed A Zayed
BACKGROUND: Peripheral arterial atheroprogression is increasingly prevalent, and is a risk factor for major limb amputations in individuals with risk factors such as diabetes. We previously demonstrated that bioactive lipids are significantly altered in arterial tissue of individuals with diabetes and advanced peripheral arterial disease. METHODS: Here we evaluated whether sphingolipid ceramide 18:1/16:0 (C16) is a cellular regulator in endothelial cells and peripheral tibial arterial tissue in individuals with diabetes...
2023: Journal of vascular surgery. Vascular science
https://read.qxmd.com/read/38037464/untargeted-metabolomics-identifies-metabolic-dysregulation-of-sphingolipids-associated-with-aggressive-chronic-lymphocytic-leukaemia-and-poor-survival
#13
JOURNAL ARTICLE
Flora Nguyen Van Long, Délya Valcourt-Gendron, Patrick Caron, Michèle Rouleau, Lyne Villeneuve, David Simonyan, Trang Le, Roxanne Sergerie, Isabelle Laverdière, Katrina Vanura, Chantal Guillemette
BACKGROUND: Metabolic dependencies of chronic lymphocytic leukaemia (CLL) cells may represent new personalized treatment approaches in patients harbouring unfavourable features. METHODS: Here, we used untargeted metabolomics and lipidomics analyses to isolate metabolomic features associated with aggressive CLL and poor survival outcomes. We initially focused on profiles associated with overexpression of the adverse metabolic marker glycosyltransferase (UGT2B17) associated with poor survival and drug resistance...
December 2023: Clinical and Translational Medicine
https://read.qxmd.com/read/38016943/cers6-dependent-ceramide-synthesis-in-hypothalamic-neurons-promotes-er-mitochondrial-stress-and-impairs-glucose-homeostasis-in-obese-mice
#14
JOURNAL ARTICLE
Philipp Hammerschmidt, Sophie M Steculorum, Cécile L Bandet, Almudena Del Río-Martín, Lukas Steuernagel, Vivien Kohlhaas, Marvin Feldmann, Luis Varela, Adam Majcher, Marta Quatorze Correia, Rhena F U Klar, Corinna A Bauder, Ecem Kaya, Marta Porniece, Nasim Biglari, Anna Sieben, Tamas L Horvath, Thorsten Hornemann, Susanne Brodesser, Jens C Brüning
Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscure. Here, we find increased expression of the C16:0 ceramide-producing ceramide synthase (CerS)6 in cultured hypothalamic neurons exposed to palmitate in vitro and in the hypothalamus of obese mice. Conditional deletion of CerS6 in hypothalamic neurons attenuates high-fat diet (HFD)-dependent weight gain and improves glucose metabolism...
November 29, 2023: Nature Communications
https://read.qxmd.com/read/37984003/lipidomics-reveals-lipid-changes-in-the-intramuscular-fat-of-geese-at-different-growth-stages
#15
JOURNAL ARTICLE
Zhi Cao, Maodou Xu, Shangzong Qi, Xinlei Xu, Wei Liu, Linyu Liu, Qiang Bao, Yang Zhang, Qi Xu, Wenming Zhao, Guohong Chen
The quality (color, tenderness, juiciness, protein content, and fat content) of poultry meat is closely linked to age, with older birds typically exhibiting increased intramuscular fat (IMF) deposition. However, specific lipid metabolic pathways involved in IMF deposition remain unknown. To elucidate the mechanisms underlying lipid changes, we conducted a study using meat geese at 2 distinct growth stages (70 and 300 d). Our findings regarding the approximate composition of the meat revealed that as the geese aged 300 d, their meat acquired a chewier texture and displayed higher levels of IMF...
October 12, 2023: Poultry Science
https://read.qxmd.com/read/37979349/targeted-sphingolipidomics-indicates-increased-c22-c24-16-ratios-of-virtually-all-assayed-classes-in-liver-kidney-and-plasma-of-fumonisin-fed-chickens
#16
JOURNAL ARTICLE
Elodie Lassallette, Pi Nyvall Collén, Philippe Guerre
The biological properties of sphinganine-(d18:0)-, sphingosine-(d18:1)-, deoxysphinganine-(m18: 0)-, deoxysphingosine-(m18:1)-, deoxymethylsphinganine-(m17:0)-, deoxymethylsphingosine-(m17:1)-, sphingadienine-(d18:2)-, and phytosphingosine-(t18:0)-sphingolipids have been reported to vary, but little is known about the effects of fumonisins, which are mycotoxins that inhibit ceramide synthase, on sphingolipids other than those containing d18:0 and d18:1. Thirty chickens divided into three groups received a control diet or a diet containing 14...
November 16, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/37968983/reduced-ceramides-are-associated-with-acute-rejection-in-liver-transplant-patients-and-skin-graft-and-hepatocyte-transplant-mice-reducing-tolerogenic-dendritic-cells
#17
JOURNAL ARTICLE
Hyun Ju Yoo, Yeogyeong Yi, Yoorha Kang, Su Jung Kim, Young-In Yoon, Phuc Huu Tran, Taewook Kang, Min Kyung Kim, Jaeseok Han, Eunyoung Tak, Chul-Soo Ahn, Gi-Won Song, Gil-Chun Park, Sung-Gyu Lee, Jae-Joong Kim, Dong-Hwan Jung, Shin Hwang, Nayoung Kim
We set up this study to understand the underlying mechanisms of reduced ceramides on immune cells in acute rejection (AR). The concentrations of ceramides and sphingomyelins were measured in the sera from hepatic transplant patients, skin graft mice and hepatocyte transplant mice by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Serum concentrations of C24 ceramide, C24:1 ceramide, C16:0 sphingomyelin, and C18:1 sphingomyelin were lower in liver transplantation (LT) recipients with than without AR...
November 30, 2023: Molecules and Cells
https://read.qxmd.com/read/37833312/ramadan-intermittent-fasting-is-associated-with-ameliorated-inflammatory-markers-and-improved-plasma-sphingolipids-ceramides-in-subjects-with-obesity-lipidomics-analysis
#18
JOURNAL ARTICLE
Mohamed Ibrahim Madkour, Md Torikul Islam, Trevor S Tippetts, Kamrul H Chowdhury, Lisa A Lesniewski, Scott A Summers, Falak Zeb, Dana N Abdelrahim, Refat AlKurd, Husam M Khraiwesh, Katia H AbuShihab, Asma AlBakri, Khaled Obaideen, MoezAlIslam E Faris
Intermittent fasting (IF) is associated with enormous metabolic alterations that underpin its diverse health effects. Changes in lipid metabolism, particularly ceramides, and other sphingolipids, are among the most notable of these alterations. This study investigated the lipidomic alterations associated with 29-30 days of Ramadan diurnal intermittent fasting (RIF) in metabolically healthy overweight and obese subjects. A prospective cohort of 57 overweight and obese adults (70% males, 38.4 ± 11...
October 13, 2023: Scientific Reports
https://read.qxmd.com/read/37816355/very-long-chain-fatty-acids-are-crucial-to-neuronal-polarity-by-providing-sphingolipids-to-lipid-rafts
#19
JOURNAL ARTICLE
Atsuko Honda, Motohiro Nozumi, Yasuyuki Ito, Rie Natsume, Asami Kawasaki, Fubito Nakatsu, Manabu Abe, Haruki Uchino, Natsuki Matsushita, Kazutaka Ikeda, Makoto Arita, Kenji Sakimura, Michihiro Igarashi
Fatty acids have long been considered essential to brain development; however, the involvement of their synthesis in nervous system formation is unclear. We generate mice with knockout of GPSN2, an enzyme for synthesis of very-long-chain fatty acids (VLCFAs) and investigate the effects. Both GPSN2-/- and GPSN2+/- mice show abnormal neuronal networks as a result of impaired neuronal polarity determination. Lipidomics of GPSN2-/- embryos reveal that ceramide synthesis is specifically inhibited depending on FA length; namely, VLCFA-containing ceramide is reduced...
October 2, 2023: Cell Reports
https://read.qxmd.com/read/37752566/ceramides-are-decreased-after-liraglutide-treatment-in-people-with-type-2-diabetes-a-post-hoc-analysis-of-two-randomized-clinical-trials
#20
JOURNAL ARTICLE
Asger Wretlind, Viktor Rotbain Curovic, Andressa de Zawadzki, Tommi Suvitaival, Jin Xu, Emilie Hein Zobel, Bernt Johan von Scholten, Rasmus Sejersten Ripa, Andreas Kjaer, Tine Willum Hansen, Tina Vilsbøll, Henrik Vestergaard, Peter Rossing, Cristina Legido-Quigley
BACKGROUND: Specific ceramides have been identified as risk markers for cardiovascular disease (CVD) years before onset of disease. Treatment with the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide has been shown to induce beneficial changes in the lipid profile and reduce the risk of CVD. Reducing lipotoxic lipids with an antidiabetic drug therapy could be a path towards precision medicine approaches for the treatment of complications to diabetes. In this post-hoc study, an investigation was carried out on the effect of liraglutide on CVD-risk associated ceramides in two randomized clinical trials including participants with type 2 diabetes (T2D)...
September 26, 2023: Lipids in Health and Disease
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