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https://www.readbyqxmd.com/read/29772049/mild-bilateral-hemorrhagic-occlusive-retinal-vasculitis-following-intracameral-vancomycin-administration-in-cataract-surgery
#1
Sruthi Arepalli, Yasha S Modi, Ryan Deasy, Sunil K Srivastava
A patient underwent cataract surgery with prophylactic intracameral vancomycin (Vancocin; Pfizer, New York City, NY) in each eye, 2 weeks apart. Four weeks after, the patient presented with a mild bilateral hemorrhagic occlusive retinal vasculitis (HORV). A systemic work-up was negative for syphilis, toxoplasmosis, Bartonella, tuberculosis, and sarcoidosis. The patient was treated with oral steroids and one intravitreal steroid injection in the left eye. Ten months after presentation, the patient's vasculitis was quiescent...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29765355/tuberculosis-the-disrupted-immune-endocrine-response-and-the-potential-thymic-repercussion-as-a-contributing-factor-to-disease-physiopathology
#2
REVIEW
Luciano D'Attilio, Natalia Santucci, Bettina Bongiovanni, María L Bay, Oscar Bottasso
Upon the pathogen encounter, the host seeks to ensure an adequate inflammatory reaction to combat infection but at the same time tries to prevent collateral damage, through several regulatory mechanisms, like an endocrine response involving the production of adrenal steroid hormones. Our studies show that active tuberculosis (TB) patients present an immune-endocrine imbalance characterized by an impaired cellular immunity together with increased plasma levels of cortisol, pro-inflammatory cytokines, and decreased amounts of dehydroepiandrosterone...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29764751/needle-wash-solution-cultures-following-ebus-tbna-with-or-without-endobronchial-intubation
#3
Daisuke Minami, Nagio Takigawa, Masahide Oki, Hideo Saka, Takuo Shibayama, Katsuyuki Kiura
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high diagnostic yield in lesions adjacent to the airways. However, complications associated with EBUS-TBNA, such as mediastinitis, have recently been reported. Oral bacteria contamination in punctured lymph nodes can cause severe infections. In the current study, we investigated whether endobronchial intubation using EBUS-TBNA can prevent oral bacterial contamination of punctured lymph nodes...
May 10, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29740435/a-beneficial-effect-of-low-dose-aspirin-in-a-murine-model-of-active-tuberculosis
#4
Vera Marie Kroesen, Paula Rodríguez-Martínez, Eric García, Yaiza Rosales, Jorge Díaz, Montse Martín-Céspedes, Gustavo Tapia, Maria Rosa Sarrias, Pere-Joan Cardona, Cristina Vilaplana
An excessive, non-productive host-immune response is detrimental in active, chronic tuberculosis (TB) disease as it typically leads to tissue damage. Given their anti-inflammatory effect, non-steroidal anti-inflammatory drugs can potentially attenuate excessive inflammation in active TB disease. As such, we investigated the prophylactic and therapeutic effect of low-dose aspirin (LDA) (3 mg/kg/day), either alone or in combination with common anti-TB treatment or BCG vaccination, on disease outcome in an experimental murine model of active TB...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29721825/cure-of-tuberculosis-using-nanotechnology-an-overview
#5
REVIEW
Rout George Kerry, Sushanto Gouda, Bikram Sil, Gitishree Das, Han-Seung Shin, Gajanan Ghodake, Jayanta Kumar Patra
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), a major health issue of the present era. The bacterium inhabits the host macrophage and other immune cells where it modulates the lysosome trafficking protein, hinders the formation of phagolysosome, and blocks the TNF receptor-dependent apoptosis of host macrophage/monocytes. Other limitations such as resistance to and low bioavailability and bio-distribution of conventional drugs aid to their high virulence and human mortality. This review highlights the use of nanotechnology-based approaches for drug formulation and delivery which could open new avenues to limit the pathogenicity of tuberculosis...
May 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29707591/miliary-tuberculosis-presenting-with-meningitis-in-a-patient-treated-with-mycophenolate-for-lupus-nephritis-challenges-in-diagnosis-and-review-of-the-literature
#6
Precious Macauley, Mark Rapp, Sarah Park, Olaoluwatomi Lamikanra, Pratibha Sharma, Michael Marcelin, Kavita Sharma
Tuberculosis is one of the top 10 causes of death worldwide according to the World Health Organization. Central nervous system involvement is usually the least common presentation of tuberculosis occurring in about 1% of all cases but yet can have very devastating outcomes. Lupus nephritis is one of the most common complications of systemic lupus erythematosus with up to two thirds of patients presenting with some degree of renal dysfunction. The mainstay of treatment is glucocorticoids; however, to sustain remission, steroid sparing agents such as cyclophosphamide, azathioprine and mycophenolate mofetil are used...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29692453/controversies-in-the-management-of-cutaneous-adverse-drug-reactions
#7
Yashpal Manchanda, Sudip Das, Aarti Sarda, Projna Biswas
Some cutaneous adverse drug reactions (CADRs) are severe life-threatening conditions due to multisystem involvements with a high morbidity and mortality rates ranging from 25 - 70% and require immediate medical care. But there are huge controversies regarding the management because large clinical trials are lacking. Most frequent discussion and division occur regarding the use of systemic corticosteroid as early intervention with corticosteroids controls inflammation. Corticosteroids are potent agents that target several intracellular processes to modify almost all components of inflammatory and immune responses but their impact on the long term disease course is not known...
March 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29680795/monomac-syndrome-with-associated-neurological-deficits-and-longitudinally-extensive-cord-lesion
#8
Mastura Monif, Aamira Huq, Lynette Chee, Trevor Kilpatrick
We present a case of monocytopaenia and mycobacteria-related infection (MonoMac) syndrome in a 30-year-old man of Indian origin. The clinical diagnosis of GATA2 haploinsufficiency was suspected after an unusual neurological presentation on a background of myelodysplastic syndrome and childhood pulmonary tuberculosis. The patient had a longitudinally extensive spinal cord lesion and a lesion in the medulla. No obvious infective cause for the spinal cord MRI abnormality was found, and the lesions were presumed to be inflammatory in nature...
April 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29622703/immune-stromal-keratitis-a-rare-ocular-presentation-of-tuberculosis
#9
Deepali Singhal, Prafulla Kumar Maharana, Namrata Sharma, Jeewan S Titiyal
An 11-year-old female patient presented with diminution of vision in both the eyes for the last 4 days. She had redness, watering and photophobia for the past 11 days. Slit lamp examination revealed multiple disc-shaped corneal stromal infiltrates with an overlying epithelial defect and hypopyon in both the eyes. A provisional diagnosis of infective keratitis was made. The patient was started on empirical antimicrobial therapy. However, no improvement was noted over the next 72 hours. Microbiological examination of the corneal scraping from both the eyes was negative...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29599802/tuberculosis-induced-autoimmune-haemolytic-anaemia-a-systematic-review-to-find-out-common-clinical-presentations-investigation-findings-and-the-treatment-options
#10
REVIEW
Devarajan Rathish, Sisira Siribaddana
Background: Tuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports. Methods: PubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29581275/ipdab-a-virulence-factor-in-mycobacterium-tuberculosis-is-a-cholesterol-ring-cleaving-hydrolase
#11
Adam M Crowe, Sean D Workman, Nobuhiko Watanabe, Liam J Worrall, Natalie C J Strynadka, Lindsay D Eltis
Mycobacterium tuberculosis ( Mtb ) grows on host-derived cholesterol during infection. IpdAB, found in all steroid-degrading bacteria and a determinant of pathogenicity, has been implicated in the hydrolysis of the last steroid ring. Phylogenetic analyses revealed that IpdAB orthologs form a clade of CoA transferases (CoTs). In a coupled assay with a thiolase, IpdAB transformed the cholesterol catabolite ( R )-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA (COCHEA-CoA) and CoASH to 4-methyl-5-oxo-octanedioyl-CoA (MOODA-CoA) and acetyl-CoA with high specificity ( k cat / K m = 5...
March 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29560861/can-aspirin-help
#12
Ashwini Kalantri, Shriprakash Kalantri
Using a combination of aspirin, anti-tuberculosis drugs and steroids may help to reduce the number of strokes and deaths in patients with tuberculous meningitis.
March 21, 2018: ELife
https://www.readbyqxmd.com/read/29541156/coptidis-rhizoma-and-its-main-bioactive-components-recent-advances-in-chemical-investigation-quality-evaluation-and-pharmacological-activity
#13
REVIEW
Fan-Cheng Meng, Zheng-Feng Wu, Zhi-Qi Yin, Li-Gen Lin, Ruibing Wang, Qing-Wen Zhang
Background: Coptidis rhizoma (CR) is the dried rhizome of Coptis chinensis Franch., C. deltoidea C. Y. Cheng et Hsiao or C. teeta Wall. (Ranunculaceae) and is commonly used in Traditional Chinese Medicine for the treatment of various diseases including bacillary dysentery, typhoid, tuberculosis, epidemic cerebrospinal meningitis, empyrosis, pertussis, and other illnesses. Methods: A literature survey was conducted via SciFinder, ScieneDirect, PubMed, Springer, and Wiley databases...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29471911/the-neuro-endocrine-immune-relationship-in-pulmonary-and-pleural-tuberculosis-a-better-local-profile-in-pleural-fluid
#14
L D'Attilio, A Díaz, R D V Fernández, B Bongiovanni, N Santucci, G Dídoli, S Lioi, W Gardeñez, J L Naninni, A Del Rey, H Besedovsky, O Bottasso, M L Bay
BACKGROUND: Tuberculosis (TB) is a major health problem worldwide. In TB, the immune and central nervous systems modulate each other. The two main components of this network are the hypothalamic-pituitary-adrenal axis (HPA) and autonomic nervous system (ANS). OBJECTIVE: To elucidate neuro-endocrine-immune (NEI) interactions in pulmonary (PTB) or pleural (PLTB) TB, we analysed the relationship among compounds from these systems. METHODS: We quantified levels of catecholamines, hormones and cytokines in plasma from patients with PTB (n = 46) or PLTB (n = 12) and controls (n = 32), and in the pleural fluid from PLTB patients...
March 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29450389/unilateral-eales-disease-a-case-report
#15
Andreea Nicolcescu, Carmen Mocanu, Loredana Dinu, Andrei Olaru, Mara Ionete, Dima Alin Stefanescu
Introduction. Eales disease is an idiopathic peripheral vascular occlusive disease characterized by inflammation, ischemia, and retinal neovascularization and is hallmarked by recurrent vitreous hemorrhages and vision loss. Case report. We present a case of a 48-year-old female with recurrent floaters and decreased vision in her right eye. The onset of symptoms was in 2007 when a diagnose of retinal vasculitis was made. She had no accompanying systemic signs and symptoms and no history of ocular trauma or previous tuberculosis infection...
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29447988/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-agents-targeting-lymphoid-cells-surface-antigens-i-cd19-cd20-and-cd52
#16
REVIEW
M Mikulska, S Lanini, C Gudiol, L Drgona, G Ippolito, M Fernández-Ruiz, B Salzberger
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of agents targeting CD19, CD20 and CD52 and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29424965/prevalence-and-risk-factors-of-drug-resistant-extrapulmonary-tuberculosis
#17
Viboon Boonsarngsuk, Khattiya Mangkang, Pitak Santanirand
BACKGROUND: Physicians are usually aware of the occurrence of drug-resistant (DR) pulmonary tuberculosis (PTB), but lack concern about DR-extrapulmonary TB (EPTB). Data regarding the prevalence and risk factors of DR-EPTB remain limited. OBJECTIVES: To determine the prevalence and risk factors of DR-EPTB. METHODS: A retrospective study was performed in patients who had culture-proven Mycobacterium tuberculosis (MTB) from various specimens between January 2013 and December 2015...
February 9, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29422802/efficacy-and-safety-of-the-adalimumab-biosimilar-exemptia-as-induction-therapy-in-moderate-to-severe-ulcerative-colitis
#18
Vandana Midha, Ramit Mahajan, Varun Mehta, Vikram Narang, Arshdeep Singh, Kirandeep Kaur, Ajit Sood
Background/Aims: Data on the efficacy and safety of the adalimumab biosimilar Exemptia are limited. Methods: Patients with moderate-to-severe active steroid-refractory ulcerative colitis (UC) treated at Dayanand Medical College and Hospital, India were offered cyclosporine A, biologicals or biosimilars, or surgery. A retrospective analysis was conducted on patients who were treated with the adalimumab biosimilar, Exemptia. These patients were administered an induction dosing schedule of 160 mg Exemptia at week 0, 80 mg at week 2, and then 40 mg every other week from week 4 to 8...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29417038/miliary-tuberculosis-with-pulmonary-and-extrapulmonary-component-complicated-with-acute-respiratory-distress-syndrome
#19
Bhupen Barman, Iadarilang Tiewsoh, Kyrshanlang G Lynrah, Baphira Wankhar, Taso Beyong, Neel Kanth Issar
Miliary tuberculosis results from the lymphohematogenous spread of the tubercle bacilli to the vascular beds in the lungs and other organs. Diagnosis is made by clinical judgment and chest X-ray showing miliary mottling of the lung fields. Another imaging study like computed tomography imaging of the lungs and abdomen can also be supportive in diagnosing miliary tuberculosis. We present a case of miliary tuberculosis in an immunocompetent young male with atypical manifestation of a left-sided pleural effusion and a life-threatening complication of acute respiratory distress syndrome during hospital stay which required noninvasive mechanical ventilation and steroids therapy, along with antitubercular medication...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29386209/when-a-wound-is-the-harbinger-of-a-serious-underlying-systemic-illness
#20
Shweta Kishore, Varun Mittal, Shradha Ahuja, Vikas Majithia
A 55-year-old woman presented with progressive enlarging and painful non-healing ulcers on her bilateral lower extremities; biopsy was consistent with pyoderma gangrenosum. Workup for an underlying illness revealed a cavitary lung nodule and an ulcerating mass in the anal canal. Patient did not have any respiratory or gastrointestinal symptoms. Differential diagnosis included inflammatory bowel disease, rectal carcinoma or infection such as tuberculosis, fungal process. Histopathology did not reveal any malignancy, inflammatory bowel disease or infection...
January 31, 2018: BMJ Case Reports
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