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https://www.readbyqxmd.com/read/28913327/in-vivo-evaluation-of-the-acute-pulmonary-response-to-poractant-alfa-and-bovactant-treatments-in-lung-lavaged-adult-rabbits-and-in-preterm-lambs-with-respiratory-distress-syndrome
#1
Francesca Ricci, Fabrizio Salomone, Elke Kuypers, Daan Ophelders, Maria Nikiforou, Monique Willems, Tobias Krieger, Xabier Murgia, Matthias Hütten, Boris W Kramer, Federico Bianco
BACKGROUND: Poractant alfa (Curosurf(®)) and Bovactant (Alveofact(®)) are two animal-derived pulmonary surfactants preparations approved for the treatment of neonatal respiratory distress syndrome (nRDS). They differ in their source, composition, pharmaceutical form, and clinical dose. How much these differences affect the acute pulmonary response to treatment is unknown. OBJECTIVES: Comparing these two surfactant preparations in two different animal models of respiratory distress focusing on the short-term response to treatment...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28871620/oropharyngeal-surfactant-can-improve-initial-stabilisation-and-reduce-rescue-intubation-in-infants-born-below-25-weeks-of-gestation
#2
Tereza Lamberska, Eva Settelmayerova, Jan Smisek, Marketa Luksova, Gabriela Maloskova, Richard Plavka
AIM: Minimally aggressive and easily performed techniques that facilitate spontaneous respiratory stabilisation are required to reduce rescue intubation in extremely premature infants. This study evaluated the feasibility and safety of administering surfactant into the pharynx of infants born at less than 25 weeks immediately after birth. METHODS: This study of 19 infants was conducted from January 2013 to July 2014 in a tertiary perinatal centre in Prague. We administered 1...
September 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28839101/hyperoxia-treatment-of-trek-1-trek-2-traak-deficient-mice-is-associated-with-a-reduction-in-surfactant-proteins
#3
Andreas Schwingshackl, Benjamin Lopez, Bin Teng, Charlean L Luellen, Florian Lesage, John Belperio, Riccardo Olcese, Christopher M Waters
We previously proposed a role for the 2-pore domain potassium (K2P) channel TREK-1 in hyperoxia (HO)-induced lung injury. To determine whether redundancy between the 3 TREK isoforms (TREK-1, TREK-2, TRAAK) could protect from HO-induced injury, we now examined the effect of deletion of all 3 TREK isoforms in a clinically relevant scenario of prolonged HO exposure and mechanical ventilation (MV). We exposed WT and TREK-1/TREK-2/TRAAK-deficient (triple ko) mice to either room air, 72 hours HO, MV (high and low tidal volume), or a combination of HO+MV, and measured quasi-static lung compliance, BAL protein concentration, histologic lung injury scores (LIS), cellular apoptosis, and cytokine levels...
August 24, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28778052/interaction-of-levofloxacin-with-lung-surfactant-at-the-air-water-interface
#4
Stephanie Ortiz-Collazos, Evelina D Estrada-López, Alline A Pedreira, Paulo H S Picciani, Osvaldo N Oliveira, Andre S Pimentel
The molecular-level interaction of levofloxacin with lung surfactant was investigated using Langmuir monolayers and atomistic molecular dynamics (MD) simulations. In the simulation, the DPPC/POPC mixed monolayer was used as a lung surfactant model and the molecules of levofloxacin were placed at the air-lipid interface to mimic the adsorption process on the lung surfactant model. The simulation results indicate that amphoteric levofloxacin expands the lung surfactant, also stabilizing the film for levofloxacin fractions until 10% w/w at least...
July 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28742723/supraglottic-atomization-of-surfactant-in-spontaneously-breathing-lambs-receiving-continuous-positive-airway-pressure
#5
Ilaria Milesi, David G Tingay, Anna Lavizzari, Federico Bianco, Emanuela Zannin, Paolo Tagliabue, Fabio Mosca, Maria Luisa Ventura, Anushi Rajapaksa, Elizabeth J Perkins, Don Black, Marco Di Castri, Magdy Sourial, Gerhard Pohlmann, Raffaele L Dellaca'
OBJECTIVES: To determine the short-term tolerance, efficacy, and lung deposition of supraglottic atomized surfactant in spontaneously breathing lambs receiving continuous positive airway pressure. DESIGN: Prospective, randomized animal study. SETTING: Animal research laboratory. SUBJECTS: Twenty-two preterm lambs on continuous positive airway pressure (132 ± 1 d gestational age). INTERVENTIONS: Animals receiving continuous positive airway pressure via binasal prongs at 8 cm H2O were randomized to receive atomized surfactant at approximately 60-minute of life (atom; n = 15) or not (control; n = 7)...
September 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28450283/surfactant-replacement-therapy-reduces-acute-lung-injury-and-collapse-induration-related-lung-remodeling-in-the-bleomycin-model
#6
Lilian Steffen, Clemens Ruppert, Heinz-Gerd Hoymann, Manuela Funke, Simone Ebener, Christina Kloth, Christian Mühlfeld, Matthias Ochs, Lars Knudsen, Elena Lopez-Rodriguez
Bleomycin-induced lung injury leads to surfactant dysfunction and permanent loss of alveoli due to a remodeling process called collapse induration. Collapse induration also occurs in acute interstitial lung disease and idiopathic pulmonary fibrosis in humans. We hypothesized that surfactant dysfunction aggravates lung injury and early remodeling resulting in collapse induration within 7 days after lung injury. Rats received bleomycin to induce lung injury and either repetitive surfactant replacement therapy (SRT: 100 mg Curosurf/kg BW = surf group) or saline (0...
August 1, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28221717/cerebral-and-lung-effects-of-a-new-generation-synthetic-surfactant-with-sp-b-and-sp-c-analogs-in-preterm-lambs
#7
Carmen Rey-Santano, Victoria E Mielgo, Xabier Murgia, Miguel Angel Gomez-Solaetxe, Fabrizio Salomone, Federico Bianco, Nicola Pelizzi, Begoña Loureiro, Jon López de Heredia Y Goya
BACKGROUND: Though natural surfactants (SF) are clinically superior to protein-free synthetic preparations, CHF-5633, a synthetic SF containing SP-B and SP-C analog peptides is a potential alternative to natural SF for treating neonatal respiratory distress syndrome (RDS). Nevertheless, information is lacking regarding the safety of this new treatment for the neonatal brain. We sought to compare the cerebral and pulmonary effects of this new synthetic surfactant (CHF5633) with those of natural porcine surfactant (Cursosurf) in premature lambs with RDS...
February 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28203337/comparison-of-the-efficacy-of-three-natural-surfactants-curosurf-survanta-and-alveofact-in-the-treatment-of-respiratory-distress-syndrome-among-neonates-a-randomized-controlled-trial
#8
Mirhadi Mussavi, Keyvan Mirnia, Khairollah Asadollahi
BACKGROUND: Although several different types of natural surfactants are available, including Alveofact, Curosurf, and Survanta, the preferred type and the magnitude of their effects are unknown. OBJECTIVES: This study was designed to compare the effects of these three surfactants on the gas exchange and clinical outcomes of neonates with respiratory distress syndrome (RDS). METHODS: This triple-blind randomized clinical trial studied all preterm neonates ≤ 37 weeks with RDS who were admitted to the neonatal intensive care unit (NICU) of Taleghani hospital (Tabriz, Iran) between 2012 and 2013...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28006947/lung-inflammatory-and-oxidative-alterations-after-exogenous-surfactant-therapy-fortified-with-budesonide-in-rabbit-model-of-meconium-aspiration-syndrome
#9
P Mikolka, J Kopincová, P Košútová, D Čierny, A Čalkovská, D Mokrá
Meconium aspiration syndrome (MAS) triggers inflammatory and oxidative pathways which can inactivate both pulmonary surfactant and therapeutically given exogenous surfactant. Glucocorticoid budesonide added to exogenous surfactant can inhibit inflammation and thereby enhance treatment efficacy. Neonatal meconium (25 mg/ml, 4 ml/kg) was administered intratracheally (i.t.) to rabbits. When the MAS model was prepared, animals were treated with budesonide i.t. (Pulmicort, 0.25 mg/kg, M+B); with surfactant lung lavage (Curosurf®, 10 ml/kg, 5 mg phospholipids/ml, M+S) followed by undiluted Curosurf® i...
December 22, 2016: Physiological Research
https://www.readbyqxmd.com/read/27834732/oxidant-generation-dna-damage-and-cytotoxicity-by-a-panel-of-engineered-nanomaterials-in-three-different-human-epithelial-cell-lines
#10
Waluree Thongkam, Kirsten Gerloff, Damien van Berlo, Catrin Albrecht, Roel P F Schins
Due to the steeply increased use of nanomaterials (NMs) for commercial and industrial applications, toxicological assessment of their potential harmful effects is urgently needed. In this study, we compared the DNA-damaging properties and concurrent cytotoxicity of a panel of 10 engineered NMs in three different cell lines in relation to their intrinsic oxidant generating properties. The human epithelial cell lines A549, HK-2 and HepG2 were chosen to represent relevant target organs for NMs in the lung, kidney and liver...
January 2017: Mutagenesis
https://www.readbyqxmd.com/read/27641633/biophysical-activity-of-impaired-lung-surfactant-upon-exposure-to-polymer-nanoparticles
#11
Moritz Beck-Broichsitter
Colloidal drug carriers could improve the therapy of numerous airway diseases. However, it remains unclear to what extent nanoscale particulate matter affects the biophysical function of the essential surface-active lining layer of the lungs, especially under predisposed conditions of airway diseases. Accordingly, the current study investigated the impact of defined polymer nanoparticles on impaired lung surfactants. Admixtures of plasma proteins (albumin and fibrinogen) to Curosurf led to a controllable decrease in surface activity (i...
October 11, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27441789/effect-of-pulmonary-surfactant-on-the-dissolution-stability-and-uptake-of-zinc-oxide-nanowires-by-human-respiratory-epithelial-cells
#12
Ioannis G Theodorou, Pakatip Ruenraroengsak, Andrew Gow, Stephan Schwander, Junfeng Jim Zhang, Kian Fan Chung, Teresa D Tetley, Mary P Ryan, Alexandra E Porter
Inhaled nanoparticles (NPs) have high-deposition rates in the alveolar region of the lung but the effects of pulmonary surfactant (PS) on nanoparticle bioreactivity are unclear. Here, the impact of PS on the stability and dissolution of ZnO nanowires (ZnONWs) was investigated, and linked with their bioreactivity in vitro with human alveolar epithelial type 1-like cells (TT1). Pre-incubation of ZnONWs with Curosurf® (a natural porcine PS) decreased their dissolution at acidic pH, through the formation of a phospholipid corona...
November 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27283193/antiinflammatory-effect-of-n-acetylcysteine-combined-with-exogenous-surfactant-in-meconium-induced-lung-injury
#13
P Mikolka, J Kopincova, L Tomcikova Mikusiakova, P Kosutova, A Calkovska, D Mokra
Neonatal meconium aspiration syndrome (MAS) can be treated by exogenous surfactant (S). However, aspirated meconium initiates local inflammation and oxidation which may inactivate surfactant and reduce its action. This experimental study estimated whether combined use of surfactant and the antioxidant N-acetylcysteine (NAC) can enhance effectiveness of therapy. Meconium-instilled rabbits were non-treated (M), treated with monotherapies (M + S, M + NAC), combined therapy (M + S + NAC), or received saline instead of meconium (controls, C)...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27182651/pulmonary-surfactant-mitigates-silver-nanoparticle-toxicity-in-human-alveolar-type-i-like-epithelial-cells
#14
Sinbad Sweeney, Bey Fen Leo, Shu Chen, Nisha Abraham-Thomas, Andrew J Thorley, Andrew Gow, Stephan Schwander, Junfeng Jim Zhang, Milo S P Shaffer, Kian Fan Chung, Mary P Ryan, Alexandra E Porter, Teresa D Tetley
Accompanying increased commercial applications and production of silver nanomaterials is an increased probability of human exposure, with inhalation a key route. Nanomaterials that deposit in the pulmonary alveolar region following inhalation will interact firstly with pulmonary surfactant before they interact with the alveolar epithelium. It is therefore critical to understand the effects of human pulmonary surfactant when evaluating the inhalation toxicity of silver nanoparticles. In this study, we evaluated the toxicity of AgNPs on human alveolar type-I-like epithelial (TT1) cells in the absence and presence of Curosurf(®) (a natural pulmonary surfactant substitute), hypothesising that the pulmonary surfactant would act to modify toxicity...
September 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27077658/impact-of-the-new-generation-reconstituted-surfactant-chf5633-on-human-cd4-lymphocytes
#15
Markus Fehrholz, Kirsten Glaser, Silvia Seidenspinner, Barbara Ottensmeier, Tore Curstedt, Christian P Speer, Steffen Kunzmann
BACKGROUND: Natural surfactant preparations, commonly isolated from porcine or bovine lungs, are used to treat respiratory distress syndrome in preterm infants. Besides biophysical effectiveness, several studies have documented additional immunomodulatory properties. Within the near future, synthetic surfactant preparations may be a promising alternative. CHF5633 is a new generation reconstituted synthetic surfactant preparation with defined composition, containing dipalmitoyl-phosphatidylcholine, palmitoyl-oleoyl-phosphatidylglycerol and synthetic analogs of surfactant protein (SP-) B and SP-C...
2016: PloS One
https://www.readbyqxmd.com/read/27010895/effects-of-surfactant-budesonide-therapy-on-oxidative-modifications-in-the-lung-in-experimental-meconium-induced-lung-injury
#16
P Mikolka, J Kopincova, L Tomcikova Mikusiakova, P Kosutova, M Antosova, A Calkovska, D Mokra
Meconium aspiration syndrome (MAS) is a serious condition, which can be treated with exogenous surfactant and mechanical ventilation. However, meconium-induced inflammation, lung edema and oxidative damage may inactivate delivered surfactant and thereby reduce effectiveness of the therapy. As we presumed that addition of anti-inflammatory agent into the surfactant may alleviate inflammation and enhance efficiency of the therapy, this study was performed to evaluate effects of surfactant therapy enriched with budesonide versus surfactant-only therapy on markers of oxidative stress in experimental model of MAS...
February 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/26984182/influence-of-agglomeration-and-specific-lung-lining-lipid-protein-interaction-on-short-term-inhalation-toxicity
#17
Wendel Wohlleben, Marc D Driessen, Simon Raesch, Ulrich F Schaefer, Christine Schulze, Bernhard von Vacano, Antje Vennemann, Martin Wiemann, Christian A Ruge, Herbert Platsch, Sarah Mues, Rainer Ossig, Janina M Tomm, Jürgen Schnekenburger, Thomas A J Kuhlbusch, Andreas Luch, Claus-Michael Lehr, Andrea Haase
Lung lining fluid is the first biological barrier nanoparticles (NPs) encounter during inhalation. As previous inhalation studies revealed considerable differences between surface functionalized NPs with respect to deposition and toxicity, our aim was to investigate the influence of lipid and/or protein binding on these processes. Thus, we analyzed a set of surface functionalized NPs including different SiO2 and ZrO2 in pure phospholipids, CuroSurf(TM) and purified native porcine pulmonary surfactant (nS). Lipid binding was surprisingly low for pure phospholipids and only few NPs attracted a minimal lipid corona...
September 2016: Nanotoxicology
https://www.readbyqxmd.com/read/26954481/intratracheal-atomized-surfactant-provides-similar-outcomes-as-bolus-surfactant-in-preterm-lambs-with-respiratory-distress-syndrome
#18
Ilaria Milesi, David G Tingay, Emanuela Zannin, Federico Bianco, Paolo Tagliabue, Fabio Mosca, Anna Lavizzari, Maria Luisa Ventura, C Elroy Zonneveld, Elizabeth J Perkins, Don Black, Magdy Sourial, Raffaele L Dellacá
BACKGROUND: Aerosolization of exogenous surfactant remains a challenge. This study is aimed to evaluate the efficacy of atomized poractant alfa (Curosurf) administered with a novel atomizer in preterm lambs with respiratory distress syndrome. METHODS: Twenty anaesthetized lambs, 127 ± 1 d gestational age, (mean ± SD) were instrumented before birth and randomized to receive either (i) positive pressure ventilation without surfactant (Control group), (ii) 200 mg/kg of bolus instilled surfactant (Bolus group) at 10 min of life or (iii) 200 mg/kg of atomized surfactant (Atomizer group) over 60 min from 10 min of life...
July 2016: Pediatric Research
https://www.readbyqxmd.com/read/26884641/in-vitro-evaluation-of-a-device-for-intra-pulmonary-aerosol-generation-and-delivery
#19
Zeeshan H Syedain, Amir A Naqwi, Myrna Dolovich, Arif Somani
For infants born with respiratory distress syndrome (RDS), liquid bolus delivery of surfactant administered through an endotracheal tube is common practice. While this method is generally effective, complications such as transient hypoxia, hypercapnia, and altered cerebral blood flow may occur. Aerosolized surfactant therapy has been explored as an alternative. Unfortunately, past efforts have led to disappointing results as aerosols were generated outside the lungs with significant pharyngeal deposition and minimal intrapulmonary instillation...
September 1, 2015: Aerosol Science and Technology: the Journal of the American Association for Aerosol Research
https://www.readbyqxmd.com/read/26790130/effects-of-the-new-generation-synthetic-reconstituted-surfactant-chf5633-on-pro-and-anti-inflammatory-cytokine-expression-in-native-and-lps-stimulated-adult-cd14-monocytes
#20
Kirsten Glaser, Markus Fehrholz, Tore Curstedt, Steffen Kunzmann, Christian P Speer
BACKGROUND: Surfactant replacement therapy is the standard of care for the prevention and treatment of neonatal respiratory distress syndrome. New generation synthetic surfactants represent a promising alternative to animal-derived surfactants. CHF5633, a new generation reconstituted synthetic surfactant containing SP-B and SP-C analogs and two synthetic phospholipids has demonstrated biophysical effectiveness in vitro and in vivo. While several surfactant preparations have previously been ascribed immunomodulatory capacities, in vitro data on immunomodulation by CHF5633 are limited, so far...
2016: PloS One
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