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SCI, Inflammation

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https://www.readbyqxmd.com/read/28722682/activation-of-the-nrf2-are-signaling-pathway-by-probucol-contributes-to-inhibiting-inflammation-and-neuronal-apoptosis-after-spinal-cord-injury
#1
Zipeng Zhou, Chang Liu, Shurui Chen, Haosen Zhao, Kang Zhou, Wei Wang, Yajiang Yuan, Zhuo Li, Yue Guo, Zhaoliang Shen, Xifan Mei
The nuclear erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway plays an essential role in the cellular antioxidant and anti-inflammatory responses. Spinal cord injury (SCI) results in a massive release of inflammatory factors and free radicals, which seriously compromise nerve recovery and axon regeneration. In this study, we examined the efficacy of probucol on anti-inflammatory responses and functional recovery after SCI by activating the Nrf2/ARE signaling pathway. We also investigated the mechanism by which inflammation is inhibited in this process...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28716590/lumbar-muscle-inflammation-alters-spinally-mediated-locomotor-recovery-induced-by-training-in-a-mouse-model-of-complete-spinal-cord-injury
#2
Renaud Jeffrey-Gauthier, Mathieu Piché, Hugues Leblond
Locomotor networks after spinal cord injury (SCI) are shaped by training-activated proprioceptive and cutaneous inputs. Nociception from injured tissues may alter these changes but has largely been overlooked. The objective of the present study was to ascertain whether lumbar muscle inflammation hinders locomotion recovery in a mouse model of complete SCI. Lower limb kinematics during treadmill training was assessed before and after complete SCI at T8 (2, 7, 14, 21 and 28days post-injury). Locomotor recovery was compared in 4 groups of CD1 mice: control spinal mice; spinal mice with daily locomotor training; spinal mice with lumbar muscle inflammation (Complete Freund's Adjuvant (CFA) injection); and spinal mice with locomotor training and CFA...
July 15, 2017: Neuroscience
https://www.readbyqxmd.com/read/28716393/combine-effect-of-chondroitinase-abc-and-low-level-laser-660nm-on-spinal-cord-injury-model-in-adult-male-rats
#3
Atousa Janzadeh, Arash Sarveazad, Mahmoud Yousefifard, Sima Dameni, Fazel Sahraneshin Samani, Kobra Mokhtarian, Farinaz Nasirinezhad
After spinal cord injury (SCI) there are many recoveries inhibiting factors such as chondroitin sulfate proteoglycan (CSPG) and inflammation. The present study investigated the combinational effect of low level laser therapy (LLLT) as anti-inflammatory agent and Chondroitinase ABC (ChABC) enzyme as CSPG digesting factor on spinal cord after injury. This study performed on 44 male Wistar rats, spinal cord injury induced by a clip compression injury. Animals received two-weeks treatment of 660nm low level laser (LLL) and intraspinal injection of 1μg ChABC...
July 14, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28696010/myelin-as-an-inflammatory-mediator-myelin-interactions-with-complement-macrophages-and-microglia-in-spinal-cord-injury
#4
REVIEW
Timothy J Kopper, John C Gensel
Spinal cord injury (SCI) triggers chronic intraspinal inflammation consisting of activated resident and infiltrating immune cells (especially microglia/macrophages). The environmental factors contributing to this protracted inflammation are not well understood; however, myelin lipid debris is a hallmark of SCI. Myelin is also a potent macrophage stimulus and target of complement-mediated clearance and inflammation. The downstream effects of these neuroimmune interactions have the potential to contribute to ongoing pathology or facilitate repair...
July 11, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28672950/tocotrienol-alleviates-inflammation-and-oxidative-stress-in-a-rat-model-of-spinal-cord-injury-via-suppression-of-transforming-growth-factor-%C3%AE
#5
Chuanhui Xun, Mardan Mamat, Hailong Guo, Pulat Mamati, Jun Sheng, Jian Zhang, Tao Xu, Weidong Liang, Rui Cao, Weibin Sheng
In recent years accumulating evidence has indicated that tocotrienol exhibits an oxidation resistance function, decreased cholesterol function, inhibits cancer function and has unique physiological functions, including anti-inflammatory, anti-apoptotic and anti-oxidative properties. The present study investigated the effect of tocotrienols on spinal cord injury (SCI) by evaluating oxidative stress, inflammation and inducible nitric oxide synthase (iNOS) in rats. A rat model of SCI was induced by operation. SCI rats were treated with 120 mg/kg/day tocotrienol once a day for eight consecutive weeks...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28665182/systemic-administration-of-exosomes-released-from-mesenchymal-stromal-cells-attenuates-apoptosis-inflammation-and-promotes-angiogenesis-after-contusion-spinal-cord-injury-in-rats
#6
Jiang-Hu Huang, Xiao-Ming Yin, Yang Xu, Chun-Cai Xu, Xi Lin, Fu-Biao Ye, Yong Cao, Fei-Yue Lin
Spinal cord injury (SCI) is one of the most common devastating injuries, which causes permanent disabilities such as paralysis and loss of movement or sensation. The precise pathogenic mechanisms of the disease remain unclear, and as of yet, there is no effective cure. Mesenchymal stem cells (MSCs) show promise as an effective therapy in the experimental models of SCI. MSCs secrete various factors which can modulate a hostile environment, which is called the paracrine effect. Among these paracrine molecules, exosome is considered to be the most valuable therapeutic factor...
June 30, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28598857/sdf-1-overexpression-by-mesenchymal-stem-cells-enhances-gap-43-positive-axonal-growth-following-spinal-cord-injury
#7
Andrew Nathaniel Stewart, Jessica Jane Matyas, Ryan Matthew Welchko, Alison Delanie Goldsmith, Sarah Elizabeth Zeiler, Ute Hochgeschwender, Ming Lu, Zhenhong Nan, Julien Rossignol, Gary Leo Dunbar
PURPOSE: Utilizing genetic overexpression of trophic molecules in cell populations has been a promising strategy to develop cell replacement therapies for spinal cord injury (SCI). Over-expressing the chemokine, stromal derived factor-1 (SDF-1α), which has chemotactic effects on many cells of the nervous system, offers a promising strategy to promote axonal regrowth following SCI. The purpose of this study was to explore the effects of human SDF-1α, when overexpressed by mesenchymal stem cells (MSCs), on axonal growth and motor behavior in a contusive rat model of SCI...
June 6, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28535416/the-role-of-timing-in-the-treatment-of-spinal-cord-injury
#8
REVIEW
Amene Saghazadeh, Nima Rezaei
Regeneration failure after primary spinal cord injury (SCI) leads to diverse clinical complications in a severity- and level of SCI-dependent manner. The cost of treating both of them (initial regeneration failure and following complications) would be prohibitive, particularly in less developed nations. The well-recognized circumstances arose from primary SCI include excitotoxicity and inflammation. SCI increases concentrations of extracellular amino acids (EAAs) in the severity-dependent manner and the maximum level of EAAs at the injury site will be reduced by distance from the injury site...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28508172/targeting-enolase-in-reducing-secondary-damage-in-acute-spinal-cord-injury-in-rats
#9
Azizul Haque, Mollie Capone, Denise Matzelle, April Cox, Naren L Banik
Spinal cord injury (SCI) is a complex debilitating condition leading to permanent life-long neurological deficits. The complexity of SCI suggests that a concerted multi-targeted therapeutic approach is warranted to optimally improve function. Damage to spinal cord is complicated by an increased detrimental response from secondary injury factors mediated by activated glial cells and infiltrating macrophages. While elevation of enolase especially neuron specific enolase (NSE) in glial and neuronal cells is believed to trigger inflammatory cascades in acute SCI, alteration of NSE and its subsequent effects in acute SCI remains unknown...
May 15, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28489776/is-c-reactive-protein-a-marker-of-obstructive-sleep-apnea-a-meta-analysis
#10
REVIEW
Kun Li, Peng Wei, Yanwen Qin, Yongxiang Wei
BACKGROUND: Obstructive sleep apnea (OSA) is a common disease, distinguished by recurrent episodes of upper airway obstruction during sleep, with an inflammatory component. C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP) are markers of systemic inflammation and may serve as biomarkers of OSA. METHODS: Scientific studies published from January 1, 2006, to January 1, 2016 were obtained via searches of PubMed, Embase, SCI, and China National Knowledge Internet (CNKI) using relevant terms...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28468657/hsya-alleviates-secondary-neuronal-death-through-attenuating-oxidative-stress-inflammatory-response-and-neural-apoptosis-in-sd-rat-spinal-cord-compression-injury
#11
Jun-Peng Pei, Li-Hong Fan, Kai Nan, Jia Li, Xiao-Qian Dang, Kun-Zheng Wang
BACKGROUND: Hydroxysafflor yellow A (HSYA) is a major active component of yellow pigment extracted from safflowers; this compound possesses potent neuroprotective effects both in vitro and in vivo. However, underlying mechanism of HSYA is not fully elucidated. The present study investigated the protective effects of HSYA in rat spinal cord compression injury model and related mechanisms involved. METHODS: Sprague-Dawley rats were divided as Sham, Control, and HSYA groups (n = 30 per group)...
May 3, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28450925/therapeutic-effect-of-apocynin-through-antioxidant-activity-and-suppression-of-apoptosis-and-inflammation-after-spinal-cord-injury
#12
Yijun Sun, Futai Gong, Jichao Yin, Xiaoyan Wang, Xiangyang Wang, Qing Sun, Zhiqiang Zhu, Xiaoqiang Su, Jie Zheng, Li Liu, Yang Li, Xinglv Hu, Jia Li
Spinal cord injury (SCI) is a devastating condition affecting hundreds of thousands of people worldwide annually. SCI results in activation of the inflammatory response and apoptosis, and generates oxidative stress, which has deleterious effects on the recovery of motor function. Apocynin, an inhibitor of NADPH oxidase, has been demonstrated to improve neuronal functional recovery in rat models of SCI. However, the efficacy of apocynin treatment post-SCI has not been investigated. The aim of this study was to observe the effects of apocynin on the repair of acute spinal cord damage in rats and to examine the potential beneficial effects...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28437223/exercise-and-peripheral-nerve-grafts-as-a-strategy-to-promote-regeneration-after-acute-or-chronic-spinal-cord-injury
#13
Catherine C Theisen, Rahul Sachdeva, Scarlett Austin, Danielle Kulich, Victoria Kranz, John D Houle
Therapeutic interventions after spinal cord injury (SCI) routinely are designed to address multiple aspects of the primary and/or secondary damage that occurs. Exercise has a demonstrated efficacy for post-SCI complications such as cardiovascular dysfunction, neuropathic pain, and chronic inflammation, yet there is little understanding of the mechanisms by which improvements might result from this non-invasive approach. Here we review several of our observations of molecular and cellular changes within the injured spinal cord following acute or delayed exercise regimens that illustrate the potential for positive effects on neuroprotection and rehabilitation...
May 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28436759/the-roles-of-micrornas-in-spinal-cord-injury
#14
Zhongju Shi, Hengxing Zhou, Lu Lu, Xueying Li, Zheng Fu, Jun Liu, Yi Kang, Zhijian Wei, Bin Pan, Lu Liu, Xiaohong Kong, Shiqing Feng
BACKGROUND AND PURPOSE: Spinal cord injury (SCI) involves serious damage that can result in abnormal or absent motor and sensory functions and a disruption of autonomic function, and a series of pathological reactions occur after the injury. As a type of small non-coding RNA, microRNAs (miRNAs) have been verified to inhibit gene expression via post-transcriptional regulation. This review mainly focuses on recent advances regarding the roles of miRNAs following SCI. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were adopted...
May 8, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28421532/matrix-metalloproteinase-8-inhibition-prevents-disruption-of-blood-spinal-cord-barrier-and-attenuates-inflammation-in-rat-model-of-spinal-cord-injury
#15
Hemant Kumar, Min-Jae Jo, Hyemin Choi, Manjunatha S Muttigi, Seil Shon, Byung-Joo Kim, Soo-Hong Lee, In-Bo Han
After spinal cord injury (SCI), tight junction (TJ) protein degradation increases permeability and disrupts the blood-spinal cord barrier (BSCB). The BSCB is primarily formed of endothelial cell, which forms a specialized tight seal due to the presence of TJs. BSCB disruption after SCI allows neutrophil infiltration. Matrix metalloproteinase (MMP)-8 is believed to be mainly expressed by neutrophils and is quickly released upon neutrophil activation. Here, we determined whether MMP-8 is involved in the TJ protein degradation in endothelial cells and also determined its role in the neuroinflammation after SCI...
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28409351/inflammation-and-fibrosis-in-polycystic-kidney-disease
#16
Cheng Jack Song, Kurt A Zimmerman, Scott J Henke, Bradley K Yoder
Polycystic kidney disease (PKD) is a commonly inherited disorder characterized by cyst formation and fibrosis (Wilson, N Engl J Med 350:151-164, 2004) and is caused by mutations in cilia or cilia-related proteins, such as polycystin 1 or 2 (Oh and Katsanis, Development 139:443-448, 2012; Kotsis et al., Nephrol Dial Transplant 28:518-526, 2013). A major pathological feature of PKD is the development of interstitial inflammation and fibrosis with an associated accumulation of inflammatory cells (Grantham, N Engl J Med 359:1477-1485, 2008; Zeier et al...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28381129/compression-decreases-anatomical-and-functional-recovery-and-alters-inflammation-after-contusive-spinal-cord-injury
#17
Michael B Orr, Jennifer Simkin, William M Bailey, Neha S Kadambi, Anna Leigh McVicar, Amy K Veldhorst, John C Gensel
Experimental models of spinal cord injury (SCI) typically utilize contusion or compression injuries. Clinically, however, SCI is heterogeneous and the primary injury mode may affect secondary injury progression and neuroprotective therapeutic efficacy. Specifically, immunomodulatory agents are of therapeutic interest because the activation state of SCI macrophages may facilitate pathology but also improve repair. It is unknown currently how the primary injury biomechanics affect macrophage activation. Therefore, to determine the effects of compression subsequent to spinal contusion, we examined recovery, secondary injury, and macrophage activation in C57/BL6 mice after SCI with or without a 20 sec compression at two contusion impact forces (50 and 75 kdyn)...
August 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28367421/coadministration-of-dexamethasone-and-melissa-officinalis-has-neuroprotective-effects-in-rat-animal-model-with-spinal-cord-injury
#18
Seyed Ruhollah Hosseini, Gholamreza Kaka, Mohammad Taghi Joghataei, Mehdi Hooshmandi, Seyed Homayoon Sadraie, Kayvan Yaghoobi, Korosh Mansoori, Alireza Mohammadi
OBJECTIVE: Spinal cord injury (SCI) causes inflammation, deformity and cell loss. It has been shown that Melissa officinalis (MO), as herbal medicine, and dexamethasone (DEX) are useful in the prevention of various neurological diseases. The present study evaluated combinational effects of DEX and MO on spinal cord injury. MATERIALS AND METHODS: Thirty six adult male Wistar rats were used in this experimental study. The weight-drop contusion method was employed to induce spinal cord injury in rats...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28363523/cordycepin-enriched-wib-801c-from-cordyceps-militaris-improves-functional-recovery-by-attenuating-blood-spinal-cord-barrier-disruption-after-spinal-cord-injury
#19
Jee Youn Lee, Hye Young Choi, Hyung Hwan Baik, Bong G Ju, Won-Ki Kim, Tae Young Yune
ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps militaris is an ingredient of traditional Chinese medicine and have been widely used for inflammatory diseases and cancer. Cordycepin is one of the major bioactive components of Cordyceps militaris, and has been known to have anti-inflammatory and anti-oxidant effects. AIM OF THIS STUDY: In the present study, we examined whether WIB-801C, a standardized and cordycepin-enriched extract of caterpillar fungus (Cordyceps militaris), would attenuate blood-spinal cord barrier (BSCB) disruption by inhibiting matrix metalloprotease (MMP)-9 activity, leading to improvement of functional outcomes after spinal cord injury (SCI)...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28346507/olive-oil-bioactives-protect-pigs-against-experimentally-induced-chronic-inflammation-independently-of-alterations-in-gut-microbiota
#20
Martin Liehr, Alessandro Mereu, Jose Javier Pastor, Jose Carlos Quintela, Stefanie Staats, Gerald Rimbach, Ignacio Rodolfo Ipharraguerre
Subclinical chronic inflammation (SCI) is associated with impaired animal growth. Previous work has demonstrated that olive-derived plant bioactives exhibit anti-inflammatory properties that could possibly counteract the growth-depressing effects of SCI. To test this hypothesis and define the underlying mechanism, we conducted a 30-day study in which piglets fed an olive-oil bioactive extract (OBE) and their control counterparts (C+) were injected repeatedly during the last 10 days of the study with increasing doses of Escherichia coli lipopolysaccharides (LPS) to induce SCI...
2017: PloS One
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