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Opioids and HIV

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https://www.readbyqxmd.com/read/29774442/integrated-models-of-care-for-individuals-with-opioid-use-disorder-how-do-we-prevent-hiv-and-hcv
#1
REVIEW
Katherine M Rich, Joshua Bia, Frederick L Altice, Judith Feinberg
PURPOSE OF REVIEW: To describe models of integrated and co-located care for opioid use disorder (OUD), hepatitis C (HCV), and HIV. RECENT FINDINGS: The design and scale-up of multidisciplinary care models that engage, retain, and treat individuals with HIV, HCV, and OUD are critical to preventing continued spread of HIV and HCV. We identified 17 models within primary care (N = 3), HIV specialty care (N = 5), opioid treatment programs (N = 6), transitional clinics (N = 2), and community-based harm reduction programs (N = 1), as well as two emerging models...
May 17, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29771793/the-association-of-chronic-pain-and-long-term-opioid-therapy-with-hiv-treatment-outcomes
#2
Jessica S Merlin, Dustin Long, William C Becker, Edward R Cachay, Katerina A Christopolous, Kasey Claborn, Heidi M Crane, E Jennifer Edelman, Richard Harding, Stefan G Kertesz, Jane M Liebschutz, W Christopher Mathews, Michael J Mugavero, Sonia Napravnik, Connall O'Cleirigh, Michael S Saag, Joanna L Starrels, Robert Gross
BACKGROUND: Chronic pain occurs in up to 85% of persons living with HIV (PLWH) and is commonly treated with long-term opioid therapy (LTOT). We investigated the impact of chronic pain and LTOT on HIV outcomes. METHODS: This was prospective cohort study conducted between 7/2015-7/2016 in five HIV primary care clinics. Chronic pain was defined as ≥moderate pain for ≥3 months on the Brief Chronic Pain Questionnaire and ≥4/10 on the Pain Enjoyment of life and General activity (PEG) questionnaire...
May 4, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29752698/opioid-use-among-those-who-have-criminal-justice-experience-harm-reduction-strategies-to-lessen-hiv-risk
#3
REVIEW
Lauren Brinkley-Rubinstein, David Cloud, Ernest Drucker, Nickolas Zaller
PURPOSE OF REVIEW: We reviewed the HIV and opioid literature relevant to harm reduction strategies for those with criminal justice experience. RECENT FINDINGS: Opioid use in the United States has risen at an alarming rate recently. This has led to increased numbers of people who inject drugs, placing new populations at risk for HIV, including those who have criminal justice experience. In recent years, there has been a gradual decrease in the number of individuals under the supervision of the criminal justice system...
May 11, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29752639/prevalence-of-hiv-viral-load-suppression-among-psychiatric-inpatients-with-comorbid-substance-use-disorders
#4
D M Coviello, R Lovato, K Apostol, M M Eisenberg, D S Metzger, R Szucs-Reed, N Kiryankova-Dalseth, D Kelly, A Jackson, M Plano, M B Blank
A consistently suppressed viral load enables HIV (+) patients to live longer, healthier lives and reduces the probability of transmitting the virus. Since the prevalence of HIV is four times higher among those with psychiatric disorders than in the general population, it is likely that this group would also have greater difficulty remaining in care and achieving viral suppression. A secondary data analysis utilizing screening data from the Preventing AIDS Through Health (PATH) for Triples (PFT) Study were examined to assess HIV load suppression among 254 psychiatric inpatients with comorbid substance use disorders in Philadelphia...
May 11, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29751763/harm-reduction-and-viral-hepatitis-c-in-european-prisons-a-cross-sectional-survey-of-25-countries
#5
Rob Bielen, Samya R Stumo, Rachel Halford, Klára Werling, Tatjana Reic, Heino Stöver, Geert Robaeys, Jeffrey V Lazarus
BACKGROUND: Current estimates suggest that 15% of all prisoners worldwide are chronically infected with the hepatitis C virus (HCV), and this number is even higher in regions with high rates of injecting drug use. Although harm reduction services such as opioid substitution therapy (OST) and needle and syringe programs (NSPs) are effective in preventing the further spread of HCV and HIV, the extent to which these are available in prisons varies significantly across countries. METHODS: The Hep-CORE study surveyed liver patient groups from 25 European countries in 2016 and mid-2017 on national policies related to harm reduction, testing/screening, and treatment for HCV in prison settings...
May 11, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29743682/preoperative-screening-for-illicit-drug-use-in-patients-undergoing-emergency-surgery-a-prospective-observational-study
#6
Jingyi Li, He Ma, Ren Liao, Yanjuan Huang, Guiyong Chen
Knowledge of illicit drug users (IDUs) is important because of the comorbidity related to drug use. In this prospective, observational study, we screened 1007 patients undergoing emergency surgery and found that 75 of them (7.5%) were IDUs The results of preoperative screening showed that the rates of HIV and syphilis infection were significantly higher in IDUs (HIV (+) 2.6%, syphilis (+) 10.7%) than in non-IDUs (HIV (+) 0, syphilis (+) 0.5%). Intraoperative consumption of remifentanil (IDUs: 1.85 ± 1...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740734/syringe-decriminalization-advocacy-in-red-states-lessons-from-the-north-carolina-harm-reduction-coalition
#7
REVIEW
David H Cloud, Tessie Castillo, Lauren Brinkley-Rubinstein, Manisha Dubey, Robert Childs
PURPOSE OF REVIEW: Syringe access programs (SAPs) are cornerstone harm reduction interventions for combatting the national opioid epidemic. The goal of this paper is to describe effective advocacy strategies for enacting syringe decriminalization legislation to foster the expansion of SAPs in high-need areas amidst political opposition. RECENT FINDINGS: Decades or research shows that SAPs prevent the transmission of HIV among people who inject drugs (PWID) and are a cost-effective tool for linking PWID to medical care, health education, and social services...
May 8, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29730586/overlap-between-harm-reduction-and-hiv-service-utilisation-among-pwid-in-india-implications-for-hiv-combination-prevention
#8
M Kumi Smith, Sunil S Solomon, Derek A T Cummings, Aylur K Srikrishnan, M Suresh Kumar, C K Vasudevan, Allison M McFall, Gregory M Lucas, David D Celentano, Shruti H Mehta
BACKGROUND: In some regions, HIV incidence is rising among people who inject drugs (PWID). Combination prevention approaches are well suited to PWID who face multiple sources of HIV risk. This analysis investigates patterns of utilisation to basic HIV services (HIV counselling and testing [HCT], antiretroviral therapy [ART]) as well as harm reduction programs (needle and syringe exchange programs [NSEP] and opioid agonist therapy [OAT]) among PWID and how utilisation of harm reduction services is associated with HIV-related care seeking behaviours...
May 3, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29708450/associations-between-pain-related-anxiety-gender-and-prescription-opioid-misuse-among-tobacco-smokers-living-with-hiv-aids
#9
Lisa R LaRowe, Lauren N Chilcott, Michael J Zvolensky, Peter A Vanable, Kelley Flood, Joseph W Ditre
BACKGROUND: People living with HIV/AIDS (PLWHA) who smoke cigarettes are vulnerable to greater pain and aberrant use of prescription pain medications. Prescription opioid misuse is highly prevalent among PLWHA and can lead to a variety of adverse outcomes. Pain-related anxiety, which has been implicated in the maintenance of both pain and tobacco dependence, may also play a role in prescription pain medication misuse. OBJECTIVES: This study aimed to test associations between pain-related anxiety and prescription opioid misuse...
April 30, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29689538/opioids-and-hiv-infection-from-pain-management-to-addiction-treatment
#10
Chinazo O Cunningham
HIV-infected persons are more likely to have chronic pain, receive opioid analgesic treatment, receive higher doses of opioids, and to have substance use disorders and mental illness compared with the general population, putting them at increased risk for opioid use disorder. Management of opioid use in HIV-infected individuals can be complex, and the limited data on opioid treatment in this population are conflicting with regard to its effect on HIV outcomes. Buprenorphine treatment for opioid use disorder improves HIV outcomes and other outcomes...
April 2018: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/29687402/verbal-and-spatial-working-memory-among-drug-using-hiv-infected-men-and-women
#11
Eileen Martin, M K Keutmann, J S Fogel, P M Maki, R Gonzalez, J Vassileva, L H Rubin, D Hardy
Working memory (WM) is a critical component of many neurocognitive functions. The literature has demonstrated consistently that WM impairment is more frequent and severe among substance-dependent individuals (SDIs) infected with HIV compared with uninfected SDIs; however, the SDIs who participated in these previous studies were primarily male. There are few published data on WM performance among HIV+ women with or without substance use disorders, and essentially no direct comparisons of WM performance between HIV+ men and women, regardless of substance use...
April 23, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29672222/macrophage-derived-extracellular-vesicles-mediates-smooth-muscle-hyperplasia-role-of-altered-mirna-cargo-in-response-to-hiv-infection-and-substance-abuse
#12
Himanshu Sharma, Mahendran Chinnappan, Stuti Agarwal, Pranjali Dalvi, Sumedha Gunewardena, Amy O'Brien-Ladner, Navneet K Dhillon
Our previous studies consistently demonstrate enhanced pulmonary vascular remodeling in HIV-infected intravenous drug users, and in simian immunodeficiency virus-infected macaques or HIV-transgenic rats exposed to opioids or cocaine. Although we reported an associated increase in perivascular inflammation, the exact role of inflammatory cells in the development of pulmonary vascular remodeling remains unknown. In this study, HIV-infected and cocaine (H+C)-treated human monocyte derived macrophages released a higher number of extracellular vesicles (EVs), compared to HIV-infected or uninfected cocaine-treated macrophages, with a significant increase in the particle size range to 100-150 nm...
April 19, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29671203/the-policy-driven-hiv-epidemic-among-opioid-users-in-the-russian-federation
#13
REVIEW
Robert Heimer
PURPOSE OF REVIEW: To explore the consequences of policies implemented in the Russian Federation in response to syndemic of HIV-1 and opioid use disorder and compare the responses to the concomitant syndemic in rural America. RECENT FINDINGS: The syndemic spread has not been reduced by policies implemented by the Russian government, which continues to underfund harm reduction efforts to reduce HIV transmission, refuses to approve evidence-based opioid agonist treatments for opioid use disorder, and relies on criminal justice and abstinence approaches to control illicit opioids...
April 18, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29662723/hiv-and-chronic-pain-part-2-addressing-the-opioid-public-health-crisis
#14
Sara D Pullen
No abstract text is available yet for this article.
October 2017: Rehabilitation Oncology
https://www.readbyqxmd.com/read/29649914/positive-affect-skills-may-improve-pain-management-in-people-with-hiv
#15
Elizabeth L Addington, Elaine O Cheung, Judith T Moskowitz
Non-opioid pain management strategies are critically needed for people with HIV. We therefore conducted a secondary analysis of pain-related outcomes in a randomized controlled trial of a positive affect skills intervention for adults newly diagnosed with HIV ( N = 159). Results suggest that, even if pain prevalence rises, positive affect skills may reduce pain interference and prevent increased use of opioid analgesics by people living with HIV. Future research should replicate and extend these findings by conducting trials that are specifically designed to target pain outcomes...
April 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29605540/the-management-of-methamphetamine-use-in-sexual-settings-among-men-who-have-sex-with-men-in-malaysia
#16
Sin How Lim, Mohd Akbar, Jeffrey A Wickersham, Adeeba Kamarulzaman, Frederick L Altice
BACKGROUND: The intentional use of illicit drugs for sexual purposes (also known as 'chemsex') is well known within the MSM communities in Malaysia although research in this population is scarce primarily because both drug use and homosexuality are illegal and stigmatised in Malaysia. METHODS: From April to December 2014, interviews were conducted with twenty men (age range 21-43) living in Greater Kuala Lumpur who had sexual intercourse with other men in the past 6 months and who used illicit drugs at least monthly in the past 3 months...
March 28, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29601405/high-risk-prescription-opioid-use-among-people-living-with-hiv
#17
Chelsea E Canan, Geetanjali Chander, Anne K Monroe, Kelly A Gebo, Richard D Moore, Allison L Agwu, G Caleb Alexander, Bryan Lau
BACKGROUND: Prescription opioid use is greater among people living with HIV (PLWH), yet little is known about the prevalence of specific types of high-risk use among these individuals. SETTING: We analyzed clinical and demographic data from the HIV Research Network (HIVRN) and prescribing data from Medicaid for non-cancer patients seeking HIV treatment at four urban clinics between 2006-2010. METHODS: HIVRN patients were included in the analytic sample if they received at least one incident opioid prescription...
March 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29596464/potential-geographic-hotspots-for-drug-injection-related-transmission-of-hiv-and-hcv-and-for-initiation-into-injecting-drug-use-in-new-york-city-2011-2015-with-implications-for-the-current-opioid-epidemic-in-the-us
#18
D C Des Jarlais, H L F Cooper, K Arasteh, J Feelemyer, C McKnight, Z Ross
OBJECTIVE: We identified potential geographic "hotspots" for drug-injecting transmission of HIV and hepatitis C virus (HCV) among persons who inject drugs (PWID) in New York City. The HIV epidemic among PWID is currently in an "end of the epidemic" stage, while HCV is in a continuing, high prevalence (> 50%) stage. METHODS: We recruited 910 PWID entering Mount Sinai Beth Israel substance use treatment programs from 2011-2015. Structured interviews and HIV/ HCV testing were conducted...
2018: PloS One
https://www.readbyqxmd.com/read/29594179/intervention-packages-to-reduce-the-impact-of-hiv-and-hcv-infections-among-people-who-inject-drugs-in-eastern-europe-and-central-asia-a-modeling-and-cost-effectiveness-study
#19
Guillaume Mabileau, Otilia Scutelniciuc, Maia Tsereteli, Ivan Konorazov, Alla Yelizaryeva, Svetlana Popovici, Karimov Saifuddin, Elena Losina, Manoela Manova, Vinay Saldanha, Jean-Elie Malkin, Yazdan Yazdanpanah
Background: We evaluated the effectiveness and cost-effectiveness of interventions targeting hepatitis C virus (HCV) and HIV infections among people who inject drugs (PWID) in Eastern Europe/Central Asia. We specifically considered the needle-syringe program (NSP), opioid substitution therapy (OST), HCV and HIV diagnosis, antiretroviral therapy (ART), and/or new HCV treatment (direct acting antiviral [DAA]) in Belarus, Georgia, Kazakhstan, Republic of Moldova, and Tajikistan. Methods: We developed a deterministic dynamic compartmental model and evaluated the number of infections averted, costs, and incremental cost-effectiveness ratios (ICERs) of interventions...
March 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29579073/the-impact-of-methadone-maintenance-therapy-on-access-to-regular-physician-care-regarding-hepatitis-c-among-people-who-inject-drugs
#20
Lianping Ti, María Eugenia Socías, Evan Wood, M-J Milloy, Ekaterina Nosova, Kora DeBeck, Thomas Kerr, Kanna Hayashi
BACKGROUND & AIMS: People who inject drugs (PWID) living with hepatitis C virus (HCV) infection often experience barriers to accessing HCV treatment and care. New, safer and more effective direct-acting antiviral-based therapies offer an opportunity to scale-up HCV-related services. Methadone maintenance therapy (MMT) programs have been shown to be effective in linking PWID to health and support services, largely in the context of HIV. The objective of the study was to examine the relationship between being enrolled in MMT and having access to regular physician care regarding HCV among HCV antibody-positive PWID in Vancouver, Canada...
2018: PloS One
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