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Shannon R Sweeney, Arthur Kavanaugh, Alessia Lodi, Bo Wang, David Boyle, Stefano Tiziani, Monica Guma
To determine whether characterisation of patients' metabolic profiles, utilising nuclear magnetic resonance (NMR) and mass spectrometry (MS), could predict response to rituximab therapy. 23 patients with active, seropositive rheumatoid arthritis (RA) on concomitant methotrexate were treated with rituximab. Patients were grouped into responders and non-responders according to the American College of Rheumatology improvement criteria, at a 20% level at 6 months. A Bruker Avance 700 MHz spectrometer and a Thermo Scientific Q Exactive Hybrid Quadrupole-Orbitrap mass spectrometer were used to acquire (1)H-NMR and ultra high pressure liquid chromatography (UPLC)-MS/MS spectra, respectively, of serum samples before and after rituximab therapy...
2016: RMD Open
Rosangela Barbiani, Carlise Rigon Dalla Nora, Rafaela Schaefer
OBJECTIVE: to identify and categorize the practices performed by nurses working in Primary Health Care and Family Health Strategy Units in light of responsibilities established by the profession's legal and programmatic frameworks and by the Brazilian Unified Health System. METHOD: a scoping review was conducted in the following databases: LILACS, IBECS, BDENF, CINAHL and MEDLINE, and the Cochrane and SciELO libraries. Original research papers written by nurses addressing nursing practices in the primary health care context were included...
2016: Revista Latino-americana de Enfermagem
Cristina V Torres Díaz, Gonzalo Martín Peña, Elena Ezquiaga, Marta Navas García, Rafael García de Sola
Gracias a los avances técnicos en técnicas neuroquirúrgicas, y debido a que el diagnóstico y la clasificación de las enfermedades psiquiátricas han evolucionado significativamente a lo largo de las últimas décadas, se están desarrollando tratamientos a nivel experimental para aquellos pacientes resistentes al manejo conservador.La anorexia nerviosa es una enfermedad de prevalencia creciente, con la tasa de mortalidad más elevada dentro de los trastornos psiquiátricos, y con aproximadamente un 20% de pacientes que presentan una evolución tórpida...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Carmen Flores Navarro-Pérez, Emilio González-Jiménez, Jacqueline Schmidt-RioVilla, José Francisco Meneses-Echávez, Jorge Enrique Correa-Bautista, María Correa-Rodríguez, Robinson Ramírez-Vélez
Objetivos: los objetivos de este estudio fueron analizar el nivel nutricional en una población de niños y adolescentes colombianos y determinar la posible relación entre el nivel nutricional y el estado nutricional según el índice de masa corporal (IMC) y la circunferencia de cintura (CC).Material y métodos: estudio transversal en 6.383 niños y adolescentes de entre 9 y 17,9 años de edad, de Bogotá, Colombia. Se aplicó de manera autodiligenciada el cuestionario Krece Plus validado en el estudio enKid como indicador del nivel nutricional con las categorías alto (test ≥ 9), medio (test 6-8) y bajo (test ≤ 5)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Marta Germán Díaz, José Manuel Moreno Villares, Pilar Gomis Muñoz
Introducción: la nutrición parenteral domiciliaria se ha convertido en un punto clave en el tratamiento de pacientes con fracaso intestinal crónico. A pesar de los importantes avances que se han producido en las últimas décadas, tanto en los accesos vasculares, como en las soluciones empleadas, las infecciones asociadas a catéter venoso central siguen constituyendo una de las complicaciones más importantes. Dentro de las estrategias para la prevención o el tratamiento de estas infecciones se encuentra el empleo de sellados con antisépticos, como el etanol o la taurolidina, o de antibióticos...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Fernanda Capella Rugno, Marysia Mara Rodrigues do Prado De Carlo
OBJECTIVE: to identify and evaluate the evidence found in the international scientific literature on the application of the Palliative Outcome Scale (POS) in clinical practice and research in Palliative Care (PC). METHOD: integrative literature review, through the search of publications in journals indexed in PubMed / MEDLINE, LILACS, SciELO and CINAHL databases, between the years 1999 and 2014. RESULTS: the final sample consisted of 11 articles...
2016: Revista Latino-americana de Enfermagem
Victoria Gómez-Murcia, Alejandro Torrecillas, Ana M deGodos, Senena Corbalán-García, Juan C Gómez-Fernández
Here we present some of our data about the interaction of idebenone and idebenol with dipalmitoyl-phosphatidylcholine (DPPC). In particular, we include data of small angle X-ray diffraction (SAXD) and wide angle X-ray diffraction experiments, obtention of electronic profiles of the membranes, (2)H-NMR and (31)P-NMR, as part of the research article: "Both idebenone and idebenol are localized near the lipid-water interface of the membrane and increase its fluidity" (Gomez-Murcia et al., 2016) [1]. These data were obtained from model membranes that included different proportions of idebenone and idebenol, at temperatures both above and below of the gel to fluid phase...
June 2016: Data in Brief
David Salomon, Michael Miloro, Antonia Kolokythas
PURPOSE: Contemporary management of ablative jaw defects includes not only hard and soft tissue reconstruction but also restoration of neurosensory function. The goal of this study was to determine the outcomes of immediate reconstruction of long-span defects (≥50 mm) of the inferior alveolar nerve (IAN) after ablative mandibular resection using allogeneic nerve grafts. MATERIALS AND METHODS: A retrospective cohort study of patients who underwent immediate reconstruction of IAN gaps of at least 50 mm with allogeneic nerve graft (AxoGen Avance, Alachua, FL) at a single academic medical center by a single surgeon (M...
June 14, 2016: Journal of Oral and Maxillofacial Surgery
Thiago Pires, Simone Gonçalves de Assis, Joviana Quintes Avanci, Renata Pires Pesce
OBJECTIVE: To describe the process of cross-cultural adaptation of the General Functioning Scale of the Family, a subscale of the McMaster Family Assessment Device, for the Brazilian population. METHODS: The General Functioning Scale of the Family was translated into Portuguese and administered to 500 guardians of children in the second grade of elementary school in public schools of Sao Gonçalo, Rio de Janeiro, Southeastern Brazil. The types of equivalences investigated were: conceptual and of items, semantic, operational, and measurement...
June 27, 2016: Revista de Saúde Pública
Nara Sibério Pinho Silveira, Camila Teixeira Moreira Vasconcelos, Ana Izabel Oliveira Nicolau, Mônica Oliveira Batista Oriá, Patricia Neyva da Costa Pinheiro, Ana Karina Bezerra Pinheiro
OBJECTIVE: to verify the association among the knowledge attitude and practice of women in relation to the smear test and the age range. METHOD: a cross-sectional research was undertaken, associated with the knowledge, attitude and practice survey at a Primary Health Care service. The sample consisted of 775 women, distributed in three age ranges: adolescent, young and elderly. RESULTS: although high rates of inappropriate knowledge were found in all age ranges, it was significantly higher among the adolescents (p=0...
June 14, 2016: Revista Latino-americana de Enfermagem
Julio Benitez Lopez, Sripad P Rao, Richard R McNeer, Roman Dudaryk
Oscillations from cardiac pulsations are normally transmitted to mediastinal structures without any consequence. Autotriggering (AT) of mechanical ventilation occurs when an inspiratory trigger, typically negative inspiratory flow in anesthesia ventilators, is met in the absence of patient effort. AT can lead to respiratory alkalosis, opioid overdose, prolonged mechanical ventilation, and lung hyperinflation. This entity has been reported in both critical care and operating room environments. Increasing the flow trigger usually resolves AT in all cases...
July 1, 2016: A & A Case Reports
Oana Carmen Drăgan, Alexandru Ştefan Fărcăşanu, Radu Septimiu Câmpian, Romulus Valeriu Flaviu Turcu
BACKGROUND AND AIMS: Visualization of the internal and external root canal morphology is very important for a successful endodontic treatment; however, it seems to be difficult considering the small size of the tooth and the complexity of the root canal system. Film-based or digital conventional radiographic techniques as well as cone beam computed tomography provide limited information on the dental pulp anatomy or have harmful effects. A new non-invasive diagnosis tool is magnetic resonance imaging, due to its ability of imaging both hard and soft tissues...
2016: Clujul Medical (1957)
Dhruvin H Hirpara, Michelle C Cleghorn, Sanjeev Sockalingam, Fayez A Quereshy
BACKGROUND: Decisions leading up to surgery are fraught with uncertainty owing to trade-offs between treatment effectiveness and quality of life. Past studies on shared decision-making (SDM) have focused on the physician-patient encounter, with little emphasis on familial and cultural factors. The literature is scarce in surgical oncology, with few studies using qualitative interviews. Our objective was to explore the complexities of SDM within the setting of colorectal cancer (CRC) surgery...
June 2016: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Tonje H Haukaas, Siver A Moestue, Riyas Vettukattil, Beathe Sitter, Santosh Lamichhane, Remedios Segura, Guro F Giskeødegård, Tone F Bathen
INTRODUCTION: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development of novel treatment strategies. However, generation of high-quality data requires that sample handling from surgical resection until analysis is performed using systematically validated procedures. In this study, we investigated the effect of postsurgical freezing delay time on global metabolic profiles and stability of individual metabolites in intact tumor tissue...
2016: Frontiers in Oncology
E Subramani, M Jothiramajayam, M Dutta, D Chakravorty, M Joshi, S Srivastava, A Mukherjee, C Datta Ray, B N Chakravarty, K Chaudhury
STUDY QUESTION: Does investigation of metabolic perturbations in endometrial tissue of women with dormant genital tuberculosis (GTB) during the window of implantation (WOI) assist in improving the understanding of endometrial receptivity? SUMMARY ANSWER: In dormant GTB cases significant alterations in endometrial tissue metabolites occur, largely related to energy metabolism and amino acid biosynthesis in dormant GTB cases. WHAT IS KNOWN ALREADY: As an intracellular pathogen, Mycobacterium tuberculosis strongly influences the metabolism of host cells causing metabolic dysregulation...
April 2016: Human Reproduction
Amit Khairnar, Jana Ruda-Kucerova, Eva Drazanova, Nikoletta Szabó, Peter Latta, Anas Arab, Birgit Hutter-Paier, Daniel Havas, Manfred Windisch, Alexandra Sulcova, Zenon Starcuk, András Király, Irena Rektorova
Diffusion kurtosis imaging (DKI) by measuring non-Gaussian diffusion allows an accurate estimation of the distribution of water molecule displacement and may correctly characterize microstructural brain changes caused by neurodegeneration. The aim of the present study was to evaluate the ability of DKI to detect changes induced by α-synuclein (α-Syn) accumulation in α-Syn overexpressing transgenic mice (TNWT-61) in both gray matter (GM) and white matter (WM) using region of interest (ROI) and tract-based spatial statistics (TBSS) analyses respectively and to explore the relationship between α-Syn accumulation and DKI metrics in our regions of interest...
December 19, 2015: Journal of Neurochemistry
Simone Gonçalves Assis, Joviana Quintas Avanci, Cristiane S Duarte
No abstract text is available yet for this article.
November 2015: Ciência & Saúde Coletiva
Natalia Aristizábal, Alex Ramírez, Jaime Hincapié-García, Estefany Laiton, Carolina Aristizábal, Diana Cuesta, Claudia Monsalve, Gloria Hincapié, Eliana Zapata, Verónica Abad, Maria-Rocio Delgado, José-Luis Torres, Andrés Palacio, José Botero
OBJECTIVE: To describe baseline characteristics of diabetic patients who were started on insulin pump and real time continuous glucose monitor (CSII-rtCGM) in a specialized center in Medellin, Colombia. MATERIALS AND METHODS: All patients with diabetes with complete data who were started on CSII-rtCGM between February 2010 and May 2014 were included. This is a descriptive analysis of the sociodemographic and clinical characteristics. RESULTS: 141 of 174 patients attending the clinic were included...
November 2015: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Stéphane Bonnet, F Gonzalez, L Mathieu, G Boddaert, E Hornez, A Bertani, J-P Avaro, X Durand, F Rongieras, P Balandraud, S Rigal, F Pons
INTRODUCTION: The composition of a French Forward Surgical Team (FST) has remained constant since its creation in the early 1950s: 12 personnel, including a general and an orthopaedic surgeon. The training of military surgeons, however, has had to evolve to adapt to the growing complexities of modern warfare injuries in the context of increasing subspecialisation within surgery. The Advanced Course for Deployment Surgery (ACDS)-called Cours Avancé de Chirurgie en Mission Extérieure (CACHIRMEX)-has been designed to extend, reinforce and adapt the surgical skill set of the FST that will be deployed...
October 13, 2015: Journal of the Royal Army Medical Corps
T Murez, X Durand, M Rivoire, G Fournier, C Dariane, M Rouprêt, J Lugagne, P Bosset, G Pignot, J Hetet, J Rigaud, R Safsaf, C Pfister, A Daste, P Sèbe, B Malavaud, J Bossavy, A Houlgatte, C Avances, P Camparo, A Flechon, S Culine, F Iborra, N Mottet, P Coloby, M Soulié
No abstract text is available yet for this article.
November 2014: Progrès en Urologie
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