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JOURNAL ARTICLE
Yan Guo, Jiatian Guo, Yifeng Li, Xiaoying Zheng, Yu Wu
Wolbachia is being developed as a biological tool to suppress mosquito populations and/or interfere with their transmitted viruses. Adult males with an artificial Wolbachia infection have been released, successfully yielding population suppression in multiple field trials. The main characteristic of the artificial Wolbachia -infected mosquitoes used in the suppression program is the lower vector competence than that in native infected/uninfected mosquitoes in horizontal and vertical transmission. Our previous studies have demonstrated that the Aedes albopictus HC line infected with a trio of Wolbachia strains exhibited almost complete blockade of dengue virus (DENV) and Zika virus (ZIKV) in horizontal and vertical transmission...
July 27, 2022: Microbiology Spectrum
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JOURNAL ARTICLE
Bernadette M Cortese, Thomas W Uhde, Aicko Y Schumann, Lisa M McTeague, Christopher T Sege, Casey D Calhoun, Carla Kmett Danielson
Anxious adults show changes in smell function that are consistent with a durable shift in sensitivity toward particular odorants and away from others. Little is known regarding the development of these changes, including whether they exist in youth, are stable during the transition from childhood to adolescence, and whether odorant properties (e.g. trigeminal features, hedonic valence) affect anxiety-related differences in detection. To address this, we measured smell detection thresholds to phenyl ethyl alanine (PEA), a rose-like odorant with little trigeminal properties, and guaiacol (GUA), a smoke-like odorant with high trigeminal properties...
January 1, 2021: Chemical Senses
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REVIEW
Ana Sofia Moreira, David Guia Cavaco, Tiago Q Faria, Paula M Alves, Manuel J T Carrondo, Cristina Peixoto
Lentiviral vectors (LVs) have been increasingly used as a tool for gene and cell therapies since they can stably integrate the genome in dividing and nondividing cells. LV production and purification processes have evolved substantially over the last decades. However, the increasing demands for higher quantities with more restrictive purity requirements are stimulating the development of novel materials and strategies to supply the market with LV in a cost-effective manner. A detailed review of each downstream process unit operation is performed, limitations, strengths, and potential outcomes being covered...
January 2021: Biotechnology Journal
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JOURNAL ARTICLE
Joaquín Martínez-López, María-Victoria Mateos, Cristina Encinas, Anna Sureda, José Ángel Hernández-Rivas, Ana Lopez de la Guía, Diego Conde, Isabel Krsnik, Elena Prieto, Rosalía Riaza Grau, Mercedes Gironella, María Jesús Blanchard, Nerea Caminos, Carlos Fernández de Larrea, María Alicia Senin, Fernando Escalante, José Enrique de la Puerta, Eugenio Giménez, Pilar Martínez-Barranco, Juan José Mateos, Luis Felipe Casado, Joan Bladé, Juan José Lahuerta, Javier de la Cruz, Jesús San-Miguel
There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes were compared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admitted at six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients were male; 75 and 77% of patients, respectively, had at least one comorbidity...
October 19, 2020: Blood Cancer Journal
#5
JOURNAL ARTICLE
Davi Felipe Farias, Terezinha Souza, Juliana Alves Costa Ribeiro Souza, Leonardo Rogério Vieira, Marta Silva Muniz, Rafael Xavier Martins, Íris Flávia Sousa Gonçalves, Eduardo Afonso Silva Pereira, Maria Eduarda Souza Maia, Marília Guia Flor Silva
No abstract text is available yet for this article.
December 2020: Environmental Toxicology and Chemistry
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JOURNAL ARTICLE
Jaime Monserrat Villatoro, Irene García García, David Bueno, Rafael de la Cámara, Miriam Estébanez, Ana López de la Guía, Francisco Abad-Santos, Cristina Antón, Gina Mejía, María José Otero, Elena Ramírez García, Jesús Frías Iniesta, Antonio Carcas, Alberto M Borobia
INTRODUCTION: Invasive aspergillosis is the most important cause of morbidity and mortality in patients with haematological diseases. At present, voriconazole is the first-line treatment for invasive fungal disease. The pharmacokinetic interindividual variability of voriconazole depends on genetic factors. CYP450 is involved in 70%-75% of total metabolism of voriconazole, mainly CYP3A4 and CYP2C19, with the remaining 25%-30% of metabolism conducted by monooxygenase flavins. CYP2C19 single nucleotide polymorphisms could explain 50%-55% of variability in voriconazole metabolism...
October 1, 2020: BMJ Open
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JOURNAL ARTICLE
Anahi Ordoñez-Torres, Cristian Torres-León, Ayerim Hernández-Almanza, Tirso Flores-Guía, Diana Luque-Contreras, Cristóbal N Aguilar, Juan Ascacio-Valdés
INTRODUCTION: Mango is used in traditional medicine in many countries. However, the processing by-products are not currently used and generate large pollution problems and high handling costs. OBJECTIVE: To study the effect of different parameters in the extraction of polyphenolic compounds from mango peels using modern and ecological ultrasound-microwave-assisted extraction technology. METHODOLOGY: Various parameters of these processes were studied: the extract was recovered by liquid chromatography using Ambetlite XAD-16...
October 1, 2020: Phytochemical Analysis: PCA
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REVIEW
Denise Mafra, Ludmila F M F Cardozo, Cristiane Moraes, Lais S G Moreira, Karla T R Teixeira, Drielly C M V Reis, Susane Fanton, Roberta Salarolli, Kamyar Kalantar-Zadeh, Jerrilynn D Burrowe
Considering the Covid-19 pandemic and that patients with CKD are included in a high-risk group, a quick nutrition guide for patients with CKD in all stages was developed, and it is available in Portuguese at https://bit.ly/2zfSjl0, in English at https://bit.ly/covid19ckd, in Spanish at https://bit.ly/guia enfermedad renal and in French at https://bit.ly/covid19maladierenale.
January 2021: Journal of Renal Nutrition
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JOURNAL ARTICLE
Irene Campi, Nicola Currò, Guia Vannucchi, Danila Covelli, Simona Simonetta, Laura Fugazzola, Lorenzo Pignataro, Davide Dazzi, Claudio Guastella, Elisa Lazzaroni, Giacinta Pirola, Mario Salvi
BACKGROUND: The overall changes of ocular motility in Graves' Orbitopathy (GO), are not easily quantifiable with the methods currently available, especially in clinical studies. The aim of the present study was to calculate parameters that quantify the changes of ocular motility in GO, in relation to the Gorman score for diplopia. METHODS: We studied 100 GO patients (Group 1) and 100 controls (Group 2). We also included 30 patients treated with intravenous methylprednisolone (iv-MP) and assessed at baseline, after 12 and 24 weeks (Group 3) and 66 patients submitted to squint surgery, assessed at baseline and after 12 weeks (Group 4)...
September 17, 2020: Thyroid: Official Journal of the American Thyroid Association
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Jürgen G Okun, Sean Conway, Kathrin V Schmidt, Jonas Schumacher, Xiaoyue Wang, Roldan de Guia, Annika Zota, Johanna Klement, Oksana Seibert, Achim Peters, Adriano Maida, Stephan Herzig, Adam J Rose
No abstract text is available yet for this article.
September 4, 2020: Molecular Metabolism
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JOURNAL ARTICLE
Habib M Fardoun, Daniyal M Alghazzawi, M Elena De la Guia
No abstract text is available yet for this article.
September 7, 2020: Methods of Information in Medicine
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JOURNAL ARTICLE
Ferdinando Draghi, Chandra Bortolotto, Guia Ferrozzi
Different ultrasound approaches have been proposed to evaluate the distal biceps brachii tendon, such as lateral, posterior, medial, and anterior, all allowing good visualization of the distal biceps tendon and its pathologic appearances. Here we describe a new method of ultrasound evaluation of the distal biceps tendon insertion with the patient in the so-called crab position. The crab position is used to evaluate the posterior compartment of the elbow but also the lateral and medial compartments. This position allows for coverage of 75% the elbow in a single position, with less discomfort for the patient and a fair amount of saved time...
April 2021: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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REVIEW
Xavier Vallès, Nils Chr Stenseth, Christian Demeure, Peter Horby, Paul S Mead, Oswaldo Cabanillas, Mahery Ratsitorahina, Minoarisoa Rajerison, Voahangy Andrianaivoarimanana, Beza Ramasindrazana, Javier Pizarro-Cerda, Holger C Scholz, Romain Girod, B Joseph Hinnebusch, Ines Vigan-Womas, Arnaud Fontanet, David M Wagner, Sandra Telfer, Yazdan Yazdanpanah, Pablo Tortosa, Guia Carrara, Jane Deuve, Steven R Belmain, Eric D'Ortenzio, Laurence Baril
Yersinia pestis, the bacterial causative agent of plague, remains an important threat to human health. Plague is a rodent-borne disease that has historically shown an outstanding ability to colonize and persist across different species, habitats, and environments while provoking sporadic cases, outbreaks, and deadly global epidemics among humans. Between September and November 2017, an outbreak of urban pneumonic plague was declared in Madagascar, which refocused the attention of the scientific community on this ancient human scourge...
August 2020: PLoS Neglected Tropical Diseases
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JOURNAL ARTICLE
Jaume Guia, Tazim Jamal
Posthumanistic inquiry is young and offers new ways to understand critical and ethical relationships, bringing new axiological perspectives to current debates around travel, mobilities and (post)modernist conceptualizations of tourism. This research note introduces a Deleuzian posthumanism paradigm with ontological, epistemological and methodological directions to approach tourism research from a non-dualist perspective. French philosopher Gilles Deleuze offers a postdualist, process-oriented ontology of difference that is vital to create radical new tourism knowledge, and avoid indefensible 'either-or' binaries in research and praxis...
September 2020: Annals of tourism research
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JOURNAL ARTICLE
Andrés Carrillo, Antonia Lopez, Luna Carrillo, Vania Caldeira, Miguel Guia, Nuria Alonso, Ana Renedo, Maria E Quintana, Juan M Sanchez, Antonio Esquinas
INTRODUCTION: The HACOR scale is a clinical score that can predict early failure of NIV in hypoxemic acute respiratory failure (ARF) The aim of this study is to analyze the validity of the HACOR scale. METHODS: A retrospective study of a cohort of over 2749 episodes on 2711 consecutive patients requiring NIV for hypoxemic ARF in a polyvalent intensive care unit. The scale was measured before starting NIV and at 1, 6, 12, 24 and 48 h after the initiation of NIV...
December 2020: Journal of Critical Care
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JOURNAL ARTICLE
Anna Sala-Cunill, José L Pérez-Formoso, Carla Torán-Barona, Zulay M Almeida-Sánchez, José A Álvarez-Fernández, Ignacio García-Núñez, Juan J Linana-Santafé, Juan A Martínez-Tadeo, Anna Boronat-Barado, José L Justicia
Aim: To assess the safety and effectiveness of an allergen immunotherapy (AIT) with a microcrystalline tyrosine-associated mite allergoid in real-world patients with allergic rhinitis (AR). Materials & methods: Retrospective, multicenter study assessing the safety of AIT in patients aged 5 to 65 years with AR, with or without asthma, sensitized to mites. Secondary objective was effectiveness, measured as unscheduled visits to healthcare centers and emergency rooms, rhinitis and asthma evolution, medication use and patients' and physicians' disease perception 12 months before and after treatment...
August 19, 2020: Immunotherapy
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JOURNAL ARTICLE
Jaqueline Goes de Jesus, Tiago Gräf, Marta Giovanetti, Maria Angélica Mares-Guia, Joilson Xavier, Maricelia Lima Maia, Vagner Fonseca, Allison Fabri, Roberto Fonseca Dos Santos, Felicidade Mota Pereira, Leandro Ferraz Oliveira Santos, Luciana Reboredo de Oliveira da Silva, Zuinara Pereira Gusmão Maia, Jananci Xavier Gomes Cerqueira, Julien Thèze, Leandro Abade, Mirza de Carvalho Santana Cordeiro, Sintia Sacramento Cerqueira Torquato, Eloisa Bahia Santana, Neuza Santos de Jesus Silva, Rosemary Sarmento Oitiçica Dourado, Ademilson Brás Alves, Adeilde do Socorro Guedes, Pedro Macedo da Silva Filho, Nuno Rodrigues Faria, Carlos F Campelo de Albuquerque, André Luiz de Abreu, Alessandro Pecego Martins Romano, Julio Croda, Rodrigo Fabiano do Carmo Said, Gabriel Muricy Cunha, Jeane Magnavita da Fonseca Cerqueira, Arabela Leal E Silva de Mello, Ana Maria Bispo de Filippis, Luiz Carlos Junior Alcantara
Yellow fever virus (YFV) causes a clinical syndrome of acute hemorrhagic hepatitis. YFV transmission involves non-human primates (NHP), mosquitoes and humans. By late 2016, Brazil experienced the largest YFV outbreak of the last 100 years, with 2050 human confirmed cases, with 681 cases ending in death and 764 confirmed epizootic cases in NHP. Among affected areas, Bahia state in Northeastern was the only region with no autochthonous human cases. By using next generation sequence approach, we investigated the molecular epidemiology of YFV in NHP in Bahia and discuss what factors might have prevented human cases...
August 2020: PLoS Neglected Tropical Diseases
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JOURNAL ARTICLE
Beatriz de la Cruz-Benito, Paula Lázaro-Del Campo, Andrés Ramírez-López, Teresa de Soto-Álvarez, Irene Sánchez-Vadillo, Eduardo García-Pérez, Abel Dos Santos-Ortas, Karem Humala-Barbier, Ana López-de la Guía, Gema Casado-Abad, Victor Jiménez-Yuste, Miguel Canales-Albendea
The COVID-19 pandemic has dramatically challenged care for cancer patients, especially those with active treatment who represent a vulnerable population for SARS-CoV-2 infection. Aggressive lymphoid neoplasms, such as diffuse large B cell lymphoma and high-grade B cell lymphoma, need to be treated without delay in order to get the best disease outcome. Because of that, our clinical practice was changed to minimise the risk of SARS-CoV-2 infection while continuing haematological treatment. In this report, we analyse the management of front-line therapy in 18 patients during the COVID-19 outbreak, as well as the results of the implemented measures in their outcome...
November 2020: British Journal of Haematology
#19
REVIEW
Roldan M de Guia
BACKGROUND AND AIMS: Glucocorticoids and the GR serve as an essential molecular mediator of stress and different physiologic processes. This review summarizes main findings from studies on the role of the GC/GR signaling in the modulation of genes for nutrient processing by the different organs involved in metabolic diseases. METHODS: Descriptive review of relevant papers known to the author was conducted. RESULTS: Several high-throughput screenings in the past 15 years have identified potential GR DNA-binding regions in different cell types with genes that are annotated to be important for the control of metabolism...
September 2020: Diabetes & Metabolic Syndrome
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REVIEW
Miguel Guia, Laura D Ciobanu, Jithin K Sreedharan, Mohamed E Abdelrahim, Gil Gonçalves, Bruno Cabrita, Jaber S Alqahtani, Jun Duan, Mohamad El-Khatib, Montserrat Diaz-Abad, Jakob Wittenstein, Habib M R Karim, Pradipta Bhakta, Paolo Ruggeri, Giancarlo Garuti, Karen E A Burns, Guy W Soo Hoo, Raffaele Scala, Antonio Esquinas
INTRODUCTION: Invasive mechanical ventilation (IMV) is associated with several complications. Placement of a long-term airway (tracheostomy) is also associated with short and long-term risks for patients. Nevertheless, tracheostomies are placed to help reduce the duration of IMV, facilitate weaning and eventually undergo successful decannulation. METHODS: We performed a narrative review by searching PubMed, Embase and Medline databases to identify relevant citations using the search terms (with synonyms and closely related words) "non-invasive ventilation", "tracheostomy" and "weaning"...
2021: Pulmonology
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