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minimally invasive follicular thyroid cancer

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https://www.readbyqxmd.com/read/27494611/comprehensive-analysis-of-the-transcriptional-and-mutational-landscape-of-follicular-and-papillary-thyroid-cancers
#1
Seong-Keun Yoo, Seungbok Lee, Su-Jin Kim, Hyeon-Gun Jee, Byoung-Ae Kim, Hyesun Cho, Young Shin Song, Sun Wook Cho, Jae-Kyung Won, Jong-Yeon Shin, Do Joon Park, Jong-Il Kim, Kyu Eun Lee, Young Joo Park, Jeong-Sun Seo
Follicular thyroid carcinoma (FTC) and benign follicular adenoma (FA) are indistinguishable by preoperative diagnosis due to their similar histological features. Here we report the first RNA sequencing study of these tumors, with data for 30 minimally invasive FTCs (miFTCs) and 25 FAs. We also compared 77 classical papillary thyroid carcinomas (cPTCs) and 48 follicular variant of PTCs (FVPTCs) to observe the differences in their molecular properties. Mutations in H/K/NRAS, DICER1, EIF1AX, IDH1, PTEN, SOS1, and SPOP were identified in miFTC or FA...
August 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27350004/-procedure-guidelines-for-radioiodine-therapy-of-differentiated-thyroid-cancer-version-4
#2
Markus Dietlein, Wolfgang Eschner, Frank Grünwald, Michael Lassmann, Frederik A Verburg, Markus Luster
The procedure guideline for radioiodine therapy of differentiated thyroid cancer (version 4) was developed in the consensus of a representative expert group. This fulfils the level S1 (first step) within the AWMF classification of Clinical Practice Guidelines (AWMF, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, Germany). This procedure guideline completed the guideline for surgical management of thyroid cancer (level S2) with the aspects from nuclear medicine. Controversies over ablative radioiodine therapy in small papillary thyroid cancers and in minimally invasive follicular cancer without angioinvasion, over empirical standard doses for ablative radioiodine therapy, and over the kind of TSH-stimulation were described and the guideline formulated a corridor of good clinical practice...
June 28, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27277113/expression-of-serine-glycine-metabolism-related-proteins-is-different-according-to-the-thyroid-cancer-subtype
#3
Woo Young Sun, Hye Min Kim, Woo-Hee Jung, Ja Seung Koo
BACKGROUND: The aim of this study was to investigate the expression and clinical implications of proteins related to serine/glycine metabolism in different subtypes of thyroid cancer. METHODS: Tissue microarray (TMA) was constructed with tissues from 557 thyroid cancers, consisting of 244 papillary thyroid carcinomas (PTC), 112 follicular carcinomas (FC), 70 medullary carcinomas (MC), 23 poorly differentiated carcinomas (PDC), and 8 anaplastic carcinomas (AC). Immunohistochemical staining of the serine/glycine metabolism-related molecules phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase, (PSAT), phosphoserine phosphatase (PSPH), serine hydromethyl transferase (SHMT), and glycine decarboxylase (GLDC) was performed with the TMA blocks and the results were analyzed together with clinicopathologic parameters...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/26959760/repeat-ultrasound-guided-fine-needle-aspiration-for-thyroid-nodules-10-mm-or-larger-can-be-performed-10-7-months-after-initial-nondiagnostic-results
#4
Hee Jung Moon, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon
OBJECTIVE: The purpose of this study is to investigate when repeat ultrasound (US)-guided fine-needle aspiration (FNA) for thyroid nodules 10 mm or larger with initial nondiagnostic results due to inadequate or unsatisfactory specimen could be performed. MATERIALS AND METHODS: A total of 228 nodules 10 mm or larger with initial nondiagnostic results in 223 patients were classified into three groups according to the first follow-up US or US-guided FNA intervals after the initial US-guided FNA: within 3 months (group 1), 3-9 months (group 2), and more than 9 months (group 3)...
April 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/26300979/the-value-of-thyroperoxidase-as-a-prognostic-factor-for-differentiated-thyroid-cancer-a-long-term-follow-up-study
#5
Yurena Caballero, Eudaldo M López-Tomassetti, Julián Favre, José R Santana, Juan J Cabrera, Juan R Hernández
BACKGROUND: Thyroperoxidase (TPO) is a membrane-bound protein essential for the production of thyroid hormones; because of this, TPO expression may be impaired in selected thyroid diseases. The goal of this study is to analyze TPO immune expression in differentiated thyroid cancer, and to determine whether TPO has any prognostic value. METHODS: A total of 139 patients who required surgery due to a thyroid nodule with signs or symptoms suspicious for malignancy during their physical, ultrasound and/or cytology examination were consecutively selected for the study...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26199237/-surgical-treatment-of-thyroid-cancer
#6
Shinichi Suzuki, Satoshi Suzuki, Izumi Nakamura, Toshihiko Fukushima, Chiyo Ookouchi
The strategy for surgical treatment of thyroid cancer differs depending on the histopathological type. In papillary thyroid cancer, which accounts for most cases of thyroid cancer, total thyroidectomy is recommended in high-risk cases with tumors of more than 5 cm or with N1, EX2, or M1 tumors in Japan. On the other hand, ipsilateral lobectomy is performed for low-risk cases with T1N0M0. Our department has also added a treatment policy for the prognostic factor, age. Prophylactic lymph node dissection is performed in the central neck region but is not recommended in the lateral neck region...
June 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26166217/cutaneous-and-bone-metastasis-of-follicular-thyroid-carcinoma-a-case-report
#7
Anju Bansal, Manveen Kaur, Varsha Narula
Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer after papillary carcinoma. Based on the extent of invasion, it has been classified into minimally and widely invasive subtypes. The minimally invasive type usually grows slowly and is clinically indolent but in rare cases has an aggressive behavior with distant metastases. The lungs and bones are the most common sites of metastasis. The literature mentions very few cases of scalp metastases. We report an unusual case of minimally invasive FTC with multiple scalp and bone metastases as the initial presenting complaint...
July 8, 2015: Tumori
https://www.readbyqxmd.com/read/26148394/uncommon-presentation-of-follicular-thyroid-carcinoma-when-chronic-back-pain-should-raise-a-flag
#8
Milliette Alvarado, Margarita Ramirez, Liurka Lopez, Maria J Marcos-Martinez, Fanor M Saavedra, Juan C Negron-Rivei, Marielba Agosto, Meliza Martinez, Rafael Gonzalez, Myriam Allende-Vigo
Follicular thyroid carcinoma is the second most common type of thyroid cancer, and its incidence has increased dramatically in recent years. Although it typically presents as a thyroid nodule, it can spread to distant sites via hematogenous dissemination. Spinal cord compression complicating thyroid carcinoma is rare with only few cases reported in the literature. This case illustrates a minimally invasive follicular carcinoma that showed such an aggressive behavior, and thus the importance of considering metastatic thyroid carcinoma in the differential diagnosis of chronic back pain, which may possibly progress to spinal cord compression carrying severe morbidity...
2014: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/26132983/implementing-the-modified-2009-american-thyroid-association-risk-stratification-system-in-thyroid-cancer-patients-with-low-and-intermediate-risk-of-recurrence
#9
Fabián Pitoia, Fernando Jerkovich, Carolina Urciuoli, Angélica Schmidt, Erika Abelleira, Fernanda Bueno, Graciela Cross, R Michael Tuttle
OBJECTIVE: The primary purpose of this study was to validate the proposed modified 2009 American Thyroid Association Risk Stratification System (M-2009-RSS) in patients with thyroid cancer and to compare the findings with those of the 2009 ATA Risk of Recurrence (2009 ATA-RR) and the Ongoing Risk of recurrence system. The secondary purpose was to assess which risk stratification system had the best predictive value to foresee the probability of structural incomplete response or the no evidence of disease (NED) status at the end of follow-up...
November 2015: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/25572906/fine-needle-aspiration-cytology-of-the-solid-variant-of-papillary-thyroid-carcinoma-a-study-of-13-cases-with-clinical-histologic-and-ultrasound-correlations
#10
Tamar A Giorgadze, Theresa Scognamiglio, Grace C H Yang
BACKGROUND: The solid variant of papillary thyroid carcinoma (SVPTC) comprises approximately 3% of thyroid cancers, and there are conflicting reports about its behavior in the literature. The cytology of SVPTC is limited to 3 single case reports, a review article, and a monograph. We present the first cytologic study of SVPTC. METHODS: Fine-needle aspiration smears obtained with ultrasound guidance from 13 patients with histologically pure SVPTC were reviewed, and the cytologic features recorded...
February 2015: Cancer Cytopathology
https://www.readbyqxmd.com/read/25508535/an-uncommon-presentation-of-follicular-thyroid-carcinoma-when-chronic-back-pain-should-raise-a-flag
#11
Milliette Alvarado, Margarita Ramirez-Vick, Liurka Lopez, Maria J Marcos-Martinez, Fanor M Saavedra, Juan C Negron-Rivera, Marielba Agosto, Meliza Martinez, Rafael Gonzalez, Myriam Allende-Vigo
Follicular thyroid carcinoma is the second most common type of thyroid cancer, and its incidence has increased dramatically in recent years. Although it typically presents as a thyroid nodule, it can spread to distant sites via hematogenous dissemination. Bone metastasis is diagnosed clinically in 2%-13% of patients with differentiated thyroid cancer; nevertheless spinal cord compression complicating thyroid carcinoma is rare and only few cases has been reported in the literature. This case illustrates a strange case of a minimally invasive follicular carcinoma that showed an aggressive behavior, and thus the importance of considering metastatic thyroid carcinoma in the differential diagnosis of chronic back pain progressing to spinal cord compression carrying a severe morbidity...
2014: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/25470908/an-uncommon-presentation-of-follicular-thyroid-carcinoma-when-chronic-back-pain-should-raise-a-flag
#12
Milliette Alvarado, Margarita Ramirez-Vick, Liurka Lopez, Maria J Marcos-Martinez, Fanor M Saavedra, Juan C Negron-Rivera, Marielba Agosto, Meliza Martinez, Rafael Gonzalez, Myriam Allende-Vigo
Follicular thyroid carcinoma is the second most common type of thyroid cancer, and its incidence has increased dramatically in recent years. Although it typically presents as a thyroid nodule, it can spread to distant sites via hematogenous dissemination. Bone metastasis is diagnosed clinically in 2%-13% of patients with differentiated thyroid cancer; nevertheless spinal cord compression complicating thyroid carcinoma is rare and only few cases has been reported in the literature. This case illustrates a strange case of a minimally invasive follicular carcinoma that showed an aggressive behavior, and thus the importance of considering metastatic thyroid carcinoma in the differential diagnosis of chronic back pain progressing to spinal cord compression carrying a severe morbidity...
2014: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/25419375/minimally-invasive-surgery-using-mini-anterior-incision-for-thyroid-diseases-a-prospective-cohort-study
#13
Mehmet Zafer Sabuncuoglu, Aylin Sabuncuoglu, Isa Sozen, Mehmet Fatih Benzin, Tugrul Cakir, Recep Cetin
AIM: Minimally invasive surgical techniques have attracted interest in all surgical specialties since 1980. The thyroidectomy technique requires meticulous surgical dissection, absolute hemostasis, en bloc tumor resection and adequate visualization of the operative field, all of which can be accomplished with minimally invasive techniques. METHODS: The study group comprised all patients undergoing MITS from its introduction in 2010 until July 2012. All data were prospectively recorded in the Elbistan Hospital and Suleyman Demirel University in Turkey...
2014: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25259908/clinical-and-molecular-features-of-h%C3%A3-rthle-cell-carcinoma-of-the-thyroid
#14
Ana-Maria Chindris, John D Casler, Victor J Bernet, Michael Rivera, Colleen Thomas, Jennifer M Kachergus, Brian M Necela, Ian D Hay, Sydney A Westphal, Clive S Grant, Geoffrey B Thompson, Richard T Schlinkert, E Aubrey Thompson, Robert C Smallridge
CONTEXT: Hürthle cell cancer (HCC) of the thyroid remains the subject of controversy with respect to natural course, treatment, and follow-up. OBJECTIVE: The objective of the study was to evaluate the clinical and molecular features associated with outcome in HCC. DESIGN: The study was a review of 173 HCC cases treated at Mayo Clinic over 11 years with a median 5.8-year follow-up. RESULTS: None of the patients with minimally invasive histology had persistent disease, clinical recurrence, or disease-related death...
January 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24790388/thyroid-follicular-carcinoma-in-a-fourteen-year-old-girl-with-graves-disease
#15
Kanako Kojima-Ishii, Kenji Ihara, Kazuhiro Ohkubo, Terumichi Matsuo, Naoko Toda, Hiroyuki Yamashita, Shinji Kono, Toshiro Hara
Here we present the case of a 14-yr-old girl who developed thyroid follicular carcinoma accompanied by Graves' disease. She was diagnosed with Graves' disease at 10 yr of age and soon achieved a euthyroid state after starting treatment. When she was 13 yr of age, her hyperthyroidism and goiter worsened despite medical therapy. Multiple nodules were found in her enlarged thyroid gland by ultrasonography. Her serum Tg level seemed within the normal range. She underwent near-total thyroidectomy for control of thyroid function...
April 2014: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/24504672/the-european-society-of-endocrine-surgeons-perspective-of-thyroid-cancer-surgery-an-evidence-based-approach
#16
EDITORIAL
Kerstin Lorenz, Bruno Niederle, Thomas Steinmüller, Henning Dralle
No abstract text is available yet for this article.
February 2014: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/24233345/minimally-invasive-follicular-thyroid-cancer-miftc-a-consensus-report-of-the-european-society-of-endocrine-surgeons-eses
#17
Gianlorenzo Dionigi, Jean-Louis Kraimps, Kurt Werner Schmid, Michael Hermann, Sien-Yi Sheu-Grabellus, Pierre De Wailly, Anthony Beaulieu, Maria Laura Tanda, Fausto Sessa
BACKGROUND: This paper aims to review controversies in the management of minimally invasive follicular thyroid carcinoma (MIFTC) and to reach an evidence-based consensus. METHOD: MEDLINE search of the literature was conducted using keywords related to MIFTC. The search term was identified in the title, abstract, or medical subject heading. Available literature meeting the inclusion criteria were assigned the appropriate levels of evidence and recommendations in accordance with accepted international standards...
February 2014: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/23596352/laparoscopic-partial-nephrectomy-of-thyroid-cancer-metastasis-case-report-and-review-of-the-literature
#18
Giovanni Cochetti, Efisio Puxeddu, Michele Del Zingaro, Francesco D'Amico, Emanuele Cottini, Francesco Barillaro, Ettore Mearini
BACKGROUND: Follicular cell thyroid carcinoma is a quite aggressive form of thyroid cancer. About 10% of follicular thyroid carcinoma shows multiple metastases: lung and bone are the most common sites of metastasis. Renal involvement from thyroid primary cancer is very rare with incidence of 4.5%-5.9%. PURPOSE: We report the first laparoscopic conservative treatment of renal metastasis from thyroid cancer. This is a new and useful approach in order to delay malignant disease progression and to reduce the surgical discomfort of the patient...
2013: OncoTargets and Therapy
https://www.readbyqxmd.com/read/23543667/genomic-dissection-of-hurthle-cell-carcinoma-reveals-a-unique-class-of-thyroid-malignancy
#19
COMPARATIVE STUDY
Ian Ganly, Julio Ricarte Filho, Stephanie Eng, Ronald Ghossein, Luc G T Morris, Yupu Liang, Nicholas Socci, Kasthuri Kannan, Qianxing Mo, James A Fagin, Timothy A Chan
CONTEXT: Hurthle cell cancer (HCC) is an understudied cancer with poor prognosis. OBJECTIVE: Our objective was to elucidate the genomic foundations of HCC. DESIGN AND SETTING: We conducted a large-scale integrated analysis of mutations, gene expression profiles, and copy number alterations in HCC at a single tertiary-care cancer institution. METHODS: Mass spectrometry-based genotyping was used to interrogate hot spot point mutations in the most common thyroid oncogenes: BRAF, RET, NRAS, HRAS, KRAS, PIK3CA, MAP2K1, and AKT1...
May 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23264214/e-cadherin-expression-is-more-associated-with-histopathological-type-of-thyroid-cancer-than-with-the-metastatic-potential-of-tumors
#20
Dorota Slowinska-Klencka, Stanislaw Sporny, Olga Stasikowska-Kanicka, Bozena Popowicz, Mariusz Klencki
The aim of this study was to evaluate the relationship between abnormal expression of E-cadherin (E-CAD) and the extracapsular extension of tumors, lymph node involvement and the presence of metastasis in various types of thyroid cancers. Histopathological specimens of 35 benign thyroid lesions and 122 malignant tumors (papillary, follicular, poorly differentiated and undifferentiated cancers) were analyzed. E-CAD immunostaining intensity, its subcellular localization, homogeneity within lesion, and the relation of staining intensity between tumor and surrounding thyroid parenchyma were evaluated...
2012: Folia Histochemica et Cytobiologica
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