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https://www.readbyqxmd.com/read/28635653/virtual-screening-against-phosphoglycerate-kinase-1-in-quest-of-novel-apoptosis-inhibitors
#1
Jie Xia, Bo Feng, Qianhang Shao, Yuhe Yuan, Xiang Simon Wang, Naihong Chen, Song Wu
Inhibition of apoptosis is a potential therapy to treat human diseases such as neurodegenerative disorders (e.g., Parkinson's disease), stroke, and sepsis. Due to the lack of druggable targets, it remains a major challenge to discover apoptosis inhibitors. The recent repositioning of a marketed drug (i.e., terazosin) as an anti-apoptotic agent uncovered a novel target (i.e., human phosphoglycerate kinase 1 (hPgk1)). In this study, we developed a virtual screening (VS) pipeline based on the X-ray structure of Pgk1/terazosin complex and applied it to a screening campaign for potential anti-apoptotic agents...
June 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28634729/analysis-of-gender-based-differences-among-surgeons-in-japan-results-of-a-survey-conducted-by-the-japan-surgical-society-part-1-working-style
#2
Kazumi Kawase, Kyoko Nomura, Ryuji Tominaga, Hirotaka Iwase, Tomoko Ogawa, Ikuko Shibasaki, Mitsuo Shimada, Tomoaki Taguchi, Emiko Takeshita, Yasuko Tomizawa, Sachiyo Nomura, Kazuhiro Hanazaki, Tomoko Hanashi, Hiroko Yamashita, Norihiro Kokudo, Kotaro Maeda
PURPOSE: To assess the working styles of men and women working as surgeons in Japan. METHODS: In July, 2014, the Japan Surgical Society invited all their members (n = 29,861), through an internet campaign, to participate in a nationwide survey of surgeons. The items investigated in this descriptive study included demographic information and working styles, based on a questionnaire. RESULTS: In total, 6211 surgeons participated (response rate 20...
June 20, 2017: Surgery Today
https://www.readbyqxmd.com/read/28634531/smallpox-vaccination-an-early-start-of-modern-medicine-in-america
#3
Dan Liebowitz
Smallpox was eradicated by the World Health Organization in 1980. Before its eradication thedisease had a mortality rate upwards of 50% and had a significant impact on society. During theAmerican Revolutionary war, smallpox outbreaks were impeding the American war effort until1777 when George Washington carried out a mass inoculation campaign in the ContinentalArmy that reduced the mortality from smallpox to less than 2%. Inoculation was an early formof vaccination that used live virus from active pustules to induce a milder, but still sometimesdeadly, case of disease...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28634153/beyond-basic-feedback-in-mobile-brief-interventions-designing-sms-message-content-for-delivery-to-young-adults-during-risky-drinking-events
#4
Cassandra J C Wright, Paul M Dietze, Megan S C Lim
BACKGROUND: Brief interventions can reduce alcohol consumption in young people through screening and delivery of personally relevant feedback. Recently, Web and mobile platforms have been harnessed to increase the reach of brief interventions. Existing literature on mobile-based alcohol brief interventions indicates mixed use of theory in developing interventions. There is no research available to guide the development of SMS text messaging (short message service, SMS) interventions delivered during risky drinking events...
June 20, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28633897/discovery-and-optimization-of-3-4-aryl-heteroarylsulfonyl-piperazin-1-yl-6-piperidin-1-yl-pyridazines-as-novel-cns-penetrant-pan-muscarinic-antagonists
#5
Aaron M Bender, Rebecca L Weiner, Vincent B Luscombe, Sonia Ajmera, Hyekyung P Cho, Sichen Chang, Xiaoyan Zhan, Alice L Rodriguez, Colleen M Niswender, Darren W Engers, Thomas M Bridges, P Jeffrey Conn, Craig W Lindsley
This letter describes the synthesis and structure activity relationship (SAR) studies of structurally novel M4 antagonists, based on a 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazine core, identified from a high-throughput screening campaign. A multi-dimensional optimization effort enhanced potency at human M4 (hM4 IC50s<200nM), with only moderate species differences noted, and with enantioselective inhibition. Moreover, CNS penetration proved attractive for this series (rat brain:plasma Kp=2...
May 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28633687/facilitators-and-barriers-experienced-by-federal-cross-sector-partners-during-the-implementation-of-a-healthy-eating-campaign
#6
Melissa Anne Fernandez, Sophie Desroches, Marie Marquis, Mylène Turcotte, Véronique Provencher
OBJECTIVE: To identify facilitators and barriers that Health Canada's (HC) cross-sector partners experienced while implementing the Eat Well Campaign: Food Skills (EWC; 2013-2014) and describe how these experiences might differ according to distinct partner types. DESIGN: A qualitative study using hour-long semi-structured telephone interviews conducted with HC partners that were transcribed verbatim. Facilitators and barriers were identified inductively and analysed according partner types...
June 21, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28633453/a-multifaceted-quality-improvement-strategy-reduces-the-risk-of-catheter-associated-urinary-tract-infection
#7
Cecelia N Theobald, Matthew J Resnick, Thomas Spain, Robert S Dittus, Christianne L Roumie
Objective: Catheter-associated urinary tract infections (CAUTIs) are common and preventable hospital-acquired infections, yet their rate continues to rise nationwide. We describe the implementation of a multifaceted program to reduce catheter use and CAUTI rates while simultaneously addressing barriers to long-term success. Design/Setting/Participants: Pre-post study of medical inpatient veterans between December 2012 and February 2015. Intervention: Five component intervention: (i) a bedside catheter reminder; (ii) multidisciplinary educational campaign; (iii) structured catheter order set with clinical decision support; (iv) automated catheter discontinuation orders; and (v) protocol for post-catheter removal care...
June 17, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28633372/farmer-suicides-a-qualitative-study-from-australia
#8
M Perceval, K Kõlves, P Reddy, D De Leo
Background: Farmers in Australia, in general, have poorer health outcomes, including higher rates of suicide. Aims: To investigate risk and protective factors and attitudes towards suicide and help-seeking among farmers living and working in New South Wales and Queensland in Australia. Methods: A qualitative study in which three farming sites were selected in each state to represent an area with a suicide rate equal to, below and above the state average...
June 14, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28631761/-management-of-outpatients-with-cardiac-disease-follow-up-timing-and-modalities
#9
Roberta Rossini, Daniela Lina, Marco Ferlini, Giuseppina Belotti, Salvatore Ivan Caico, Fabrizio Caravati, Pompilio Faggiano, Annamaria Iorio, Davide Lauri, Corrado Lettieri, Emanuela Teresa Locati, Antonio Maggi, Ferdinando Massari, Andrea Mortara, Luigi Moschini, Giuseppe Musumeci, Daniele Nassiacos, Fabrizio Negri, Domenico Pecora, Simona Pierini, Roberto Pedretti, Pierfranco Ravizza, Michele Romano, Fabrizio Oliva
The increasing rate of cardiovascular diseases, the improved survival after the acute phase, the aging of the population and the implementation of primary prevention caused an exponential increase in outpatient cardiac performance, thereby making it difficult to maintain a balance between the citizen-patient request and the economic sustainability of the healthcare system. On the other side, the prescription of many diagnostic tests with a view to defensive medicine and the related growth of patients' expectations, has led several scientific societies to educational campaigns highlighting the concept that "less is more"...
June 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28631594/human-picornaviruses-associated-with-neurological-diseases-and-their-neutralization-by-antibodies
#10
Maria Anastasina, Aušra Domanska, Kaia Palm, Sarah Butcher
Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s...
June 20, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28631171/qualitative-assessment-of-vaccination-hesitancy-among-members-of-the-apostolic-church-of-zimbabwe-a-case-study
#11
Z Machekanyanga, S Ndiaye, R Gerede, K Chindedza, C Chigodo, M E Shibeshi, J Goodson, F Daniel, L Zimmerman, R Kaiser
Vaccine hesitancy or lack of confidence in vaccines is considered a threat to the success of vaccination programs. The rise and spread of measles outbreaks in southern Africa in 2009-2010 were linked to objections among Apostolic Church members, estimated at about 3.5 million in Zimbabwe as of 2014. To inform planning of interventions for a measles-rubella vaccination campaign, we conducted an assessment of the factors contributing to vaccine hesitancy using data from various stakeholders. Among nine districts in three regions of Zimbabwe, we collected data on religious attitudes toward, and perceptions of, vaccines through focus group discussions with health workers serving Apostolic communities and members of the National Expanded Programme on Immunization; semi-structured interviews with religious leaders; and open-ended questions in structured interviews with Apostolic parents/caregivers...
June 19, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28629708/comparative-use-of-different-emission-measurement-approaches-to-determine-methane-emissions-from-a-biogas-plant
#12
Torsten Reinelt, Antonio Delre, Tanja Westerkamp, Magnus A Holmgren, Jan Liebetrau, Charlotte Scheutz
A sustainable anaerobic biowaste treatment has to mitigate methane emissions from the entire biogas production chain, but the exact quantification of these emissions remains a challenge. This study presents a comparative measurement campaign carried out with on-site and ground-based remote sensing measurement approaches conducted by six measuring teams at a Swedish biowaste treatment plant. The measured emissions showed high variations, amongst others caused by different periods of measurement performance in connection with varying operational states of the plant...
June 16, 2017: Waste Management
https://www.readbyqxmd.com/read/28629475/can-formalizing-links-among-community-health-workers-accredited-drug-dispensing-outlet-dispensers-and-health-facility-staff-increase-their-collaboration-to-improve-prompt-access-to-maternal-and-child-care-a-qualitative-study-in-tanzania
#13
Angel Dillip, Suleiman Kimatta, Martha Embrey, John C Chalker, Richard Valimba, Mariam Malliwah, John Meena, Rachel Lieber, Keith Johnson
BACKGROUND: In Tanzania, progress toward achieving the 2015 Millennium Development Goals for maternal and newborn health was slow. An intervention brought together community health workers, health facility staff, and accredited drug dispensing outlet (ADDO) dispensers to improve maternal and newborn health through a mechanism of collaboration and referral. This study explored barriers, successes, and promising approaches to increasing timely access to care by linking the three levels of health care provision...
June 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28629409/correlation-between-knowledge-on-transmission-and-prevention-of-hiv-sti-and-proficiency-in-condom-use-among-male-migrants-from-africa-and-middle-east-evaluated-by-a-condom-use-skills-score-using-a-wooden-penile-model
#14
Fabio Zoboli, Domenico Martinelli, Mariantonietta Di Stefano, Massimo Fasano, Rosa Prato, Teresa Antonia Santantonio, Jose' Ramòn Fiore
BACKGROUND: Migrants in Italy are prevalently young adults, with a higher risk of sexual transmitted infections (STI) and HIV infection. Promoting consistent as well as correct use of condoms could reduce failure rate due to their improper use. The aim of our study was to evaluate Condom Use Skills among a migrant population recently landed in Italy, hosted in a government center for asylum seekers. METHODS: The study sample was composed of 80 male migrants. Sanitary trained interviewers submitted a questionnaire to participants to investigate age, provenience, marital status, educational level and knowledge about transmission and prevention of HIV/STI...
June 19, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28626749/a-century-spent-combating-rabies-in-morocco-1911-2015-how-much-longer
#15
Sami Darkaoui, Florence Cliquet, Marine Wasniewski, Emmanuelle Robardet, Nadia Aboulfidaa, Mohammed Bouslikhane, Ouafaa Fassi-Fihri
Rabies has no known beginning in Morocco and to date, government control efforts and plans fail to eradicate the disease. A review and analysis of available epidemiological data are crucial to learn lessons from the past and to propose effective actions. Legally, animal rabies is a notifiable disease since 1913 and legislation has been updated periodically since. Dogs have always been considered as both the disease's vector and reservoir, while cattle, other herbivores, and humans are victims. Animal rabies cases evolution from 1942 to 2015 is characterized by ascending phase then decreasing one following structured rabies control plan implementation in 1980s...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28625701/one-needle-one-syringe-only-one-time-a-survey-of-physician-and-nurse-knowledge-attitudes-and-practices-around-injection-safety
#16
Rachel A Kossover-Smith, Katelyn Coutts, Kelly M Hatfield, Ronda Cochran, Hana Akselrod, Melissa K Schaefer, Joseph F Perz, Katherine Bruss
BACKGROUND: To inform development, targeting, and penetration of materials from a national injection safety campaign, an evaluation was conducted to assess provider knowledge, attitudes, and practices related to unsafe injection practices. METHODS: A panel of physicians (n = 370) and nurses (n = 320) were recruited from 8 states to complete an online survey. Questions, using 5-point Likert and Spector scales, addressed acceptability and frequency of unsafe practices (eg, reuse of a syringe on >1 patient)...
June 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28624983/how-to-increase-vaccination-acceptance-among-apostolic-communities-quantitative-results-from-an-assessment-in-three-provinces-in-zimbabwe
#17
Regina Gerede, Zorodzai Machekanyanga, Serigne Ndiaye, Kenneth Chindedza, Colline Chigodo, Messeret E Shibeshi, James Goodson, Fussum Daniel, Reinhard Kaiser
A worldwide increasing trend toward vaccine hesitancy has been reported. Measles outbreaks in southern Africa in 2009-2010 were linked to objections originating from Apostolic gatherings. Founded in Zimbabwe in the 1950s, the Apostolic church has built up a large number of followers with an estimated 3.5 million in Zimbabwe in 2014. To inform planning of interventions for the 2015 measles-rubella vaccination campaign, we assessed vaccination status and knowledge, attitudes and practices among purposive samples of Apostolic caregivers in three districts each in Harare City, Manicaland and Matabeleland South in Zimbabwe...
June 17, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28624305/durability-of-immunogenicity-and-strain-coverage-of-menbvac-a-meningococcal-vaccine-based-on-outer-membrane-vesicles-lessons-of-the-normandy-campaign
#18
Julien Sevestre, Eva Hong, Valérie Delbos, Aude Terrade, Eric Mallet, Ala-Eddine Deghmane, Ludovic Lemée, Muhamed-Kheir Taha, François Caron
OBJECTIVES: MenBvac® is an outer membrane vesicle (OMV)-based meningococcal vaccine. From 2006 to 2012, it was used to control a clonal B outbreak in Normandy (France). We aimed to analyse the durability of the response against the epidemic strain and coverage beyond the vaccine strain. These data should help to optimize the use of OMV-containing vaccines, such as the new 4CMenB/Bexsero® recombinant vaccine. METHODS: Serum bactericidal activity (SBA) was measured in two cohorts of children who received their first dose of MenBvac® at 1-5years of age and accepted to provide a blood sample either one or four years after a 2+1+1 schedule...
June 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28624072/violent-events-on-the-road-risk-perception-of-traffic-related-and-non-traffic-related-situations
#19
Lilian de Oliveira Vilela da Silva, Marilita Gnecco de Camargo Braga
This study aimed at identifying and comparing subjective risk perception regarding two different violent situations in urban roads: traffic accidents (i.e. crashes) and robberies. A robbery consists of subtracting something from someone, while seriously threatening the victim, or using violence. Robberies can be perpetrated either with or without the use of a weapon. This study was carried out in the city of Uberlândia, a medium size city in the state of Minas Gerais, south-east Brazil. A total of 383 people was interviewed at home in two boroughs of Uberlândia, using a questionnaire divided in five parts: a) personal information; b) description of crash involvement; c) description of robbery involvement; d) the chance of being involved in a crash and in a robbery within the next three years; e) willingness to pay for more safety in traffic or for more security against robberies; f) what causes more damage or harm to society, crashes or robberies...
June 14, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28624036/firearm-injuries-due-to-legal-intervention-in-children-and-adolescents-a-national-analysis
#20
Noor Joudi, Jun Tashiro, Samuel Golpanian, Sarah A Eidelson, Eduardo A Perez, Juan E Sola
BACKGROUND: Firearm injuries related to legal intervention have come under scrutiny because of recent events. METHODS: The Kids' Inpatient Database (1997-2012) was searched for firearm injuries due to legal interventions (International Classification of Diseases, ninth revision, Clinical Modification E970) requiring inpatient admission in children aged <20 y. Cases were weighted to provide national estimates. The Brady Campaign criteria were used to identify lenient versus strict gun law states...
June 15, 2017: Journal of Surgical Research
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