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Endogenous Testosterone

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https://www.readbyqxmd.com/read/29145418/testosterone-is-protective-against-impaired-glucose-metabolism-in-male-intrauterine-growth-restricted-offspring
#1
Suttira Intapad, John Henry Dasinger, Joel M Fahling, Miles A Backstrom, Barbara T Alexander
Placental insufficiency alters the intrauterine environment leading to increased risk for chronic disease including impaired glucose metabolism in low birth weight infants. Using a rat model of low birth weight, we previously reported that placental insufficiency induces a significant increase in circulating testosterone in male intrauterine growth-restricted offspring (mIUGR) in early adulthood that is lost by 12 months of age. Numerous studies indicate testosterone has a positive effect on glucose metabolism in men...
2017: PloS One
https://www.readbyqxmd.com/read/29132837/prepubertal-chrysin-exposure-upregulates-either-ar-in-male-ventral-prostate-or-ar-and-er%C3%AE-in-skene-s-paraurethral-gland-of-pubertal-and-adult-gerbils
#2
Naiara C S Ribeiro, Mônica S Campos, Mariana B Santos, Gabriela M Ayusso, Patrícia S L Vilamaior, Luis O Regasini, Sebastião R Taboga, Manoel F Biancardi, Ana P S Perez, Fernanda C A Santos
Chrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown, especially during its development and functional maturation. Thus, the aim of this study was to evaluate the effects of chrysin prepubertal exposure on the male and female prostates of both pubertal and adult gerbils. To evaluate the possible androgenic responses of chrysin, gerbils were also exposed to testosterone...
November 10, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29128547/associations-between-asymmetric-dimethylarginine-adma-nitrite-dependent-renal-carbonic-anhydrase-activity-and-plasma-testosterone-levels-in-hypogonadal-men
#3
Dimitrios Tsikas, Manfred Kinzel
BACKGROUND: Circulating inorganic nitrite (NO2(-)) is an abundant nitric oxide (NO) reservoir. Renal carbonic anhydrase (CA) mediates the absorption of urinary nitrite. The urinary nitrate-to-nitrite molar ratio UNOxR is a measure of nitrite-dependent renal CA activity. The CA family is also involved in the bioactivation of nitrite to S-nitrosothiols and NO. Thus, CA isoforms may combat atherosclerosis. METHODS: In plasma and urine of ten hypogonadal men we measured the major NO metabolites nitrite and nitrate, and the endogenous inhibitor of NO synthase (NOS) asymmetric dimethylarginine (ADMA) before and after a 24-weeks testosterone treatment to normalize plasma testosterone levels...
November 8, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29113300/deletion-of-tumor-suppressors-adenomatous-polyposis-coli-and-smad4-in-murine-luminal-epithelial-cells-causes-invasive-prostate-cancer-and-loss-of-androgen-receptor-expression
#4
Kenneth C Valkenburg, Angelo M De Marzo, Bart O Williams
Prostate cancer is the most diagnosed non-skin cancer in the US and kills approximately 27,000 men per year in the US. Additional genetic mouse models are needed that recapitulate the heterogeneous nature of human prostate cancer. The Wnt/beta-catenin signaling pathway is important for human prostate tumorigenesis and metastasis, and also drives tumorigenesis in mouse models. Loss of Smad4 has also been found in human prostate cancer and drives tumorigenesis and metastasis when coupled with other genetic aberrations in mouse models...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103172/does-constant-photoperiod-inhibit-the-onset-of-the-reproductive-cycle-in-northern-pike-esox-lucius-males
#5
I Ben Ammar, S Milla, H Missaoui, Y Ledoré, F Teletchea, P Fontaine
For most temperate and arctic fish species, photoperiod is the key abiotic factor determining the onset of the reproductive cycle, and, for many species, constant long photoperiod seems to have an inhibitory effect. Yet, there is no knowledge about the effect of photoperiod on the onset of the reproductive cycle in northern pike males. The aim of this work was to investigate the potential inhibitory effect of constant long photoperiod on pike males. Batches of fish were reared in triplicate under natural simulated photoperiod (NSP) or constant long photoperiod (CP; 16L:8D) from 14 October 2013 to 14 March 2014...
November 4, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29101011/fast-furious-and-enduring-sensitive-versus-critical-periods-in-sexual-differentiation-of-the-brain
#6
Margaret M McCarthy, Kevin Herold, Sara L Stockman
Understanding critical periods in brain development and how they impact adult functioning is a primary goal of neuroscience. The sexual differentiation of the brain is a unique critical period in that it is initiated by endogenous production of a critical signaling molecule in only one sex, testosterone in fetal males. Females, by contrast, do not produce testosterone but are highly responsive to it and remain sensitive to its masculinizing effects well past the close of the critical period in males. Compared to other well characterized critical periods, such as those for the visual system or barrel cortex, the masculinization of the brain is telescoped into a few short days and initiated prenatally...
October 31, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29097437/associations-of-endogenous-estradiol-and-testosterone-levels-with-plaque-composition-and-risk-of-stroke-in-subjects-with-carotid-atherosclerosis
#7
Marija Glisic, Blerim Mujaj, Oscar L Rueda-Ochoa, Eralda Asllanaj, Joop S Laven, Maryam Kavousi, M Kamran Ikram, Meike W Vernooij, M Arfan Ikram, Oscar H Franco, Daniel Bos, Taulant Muka
Rationale: Sex steroids may play a role in plaque composition and in stroke incidence. Objective: To study the associations of endogenous estradiol and testosterone with carotid plaque composition in elderly men and postmenopausal women with carotid atherosclerosis, as well as with risk of stroke in this population. Methods and Results: Data of 1023 postmenopausal women and 1124 men (≥45 years) with carotid atherosclerosis, from prospective population-based Rotterdam Study, were available. At baseline, total estradiol (TE) and total testosterone (TT) were measured...
November 2, 2017: Circulation Research
https://www.readbyqxmd.com/read/29067698/double-trouble-co-occurrence-of-testosterone-deficiency-and-body-fatness-associated-with-all-cause-mortality-in-us-men
#8
D S Lopez, X Qiu, S Advani, K K Tsilidis, M Khera, J Kim, A Morgentaler, R Wang, S Canfield
BACKGROUND: Testosterone deficiency (TD, total testosterone ≤ 350 ng/dL [12.15 nmol/L]) and obesity epidemic are growing in parallel in the United States. Yet the sequelae of TD and obesity on the risk of mortality remains unclear. OBJECTIVE: To investigate whether the co-occurrence of TD and overall obesity (body mass index ≥ 30 kg/m(2) ), and abdominal obesity (waist circumference ≥ 102 cm), is associated with a risk of all-cause mortality in American men...
October 25, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29065927/the-protective-role-of-estrogen-and-estrogen-receptors-in-cardiovascular-disease-and-the-controversial-use-of-estrogen-therapy
#9
REVIEW
Andrea Iorga, Christine M Cunningham, Shayan Moazeni, Gregoire Ruffenach, Soban Umar, Mansoureh Eghbali
Epidemiologic studies have previously suggested that premenopausal females have reduced incidence of cardiovascular disease (CVD) when compared to age-matched males, and the incidence and severity of CVD increases postmenopause. The lower incidence of cardiovascular disease in women during reproductive age is attributed at least in part to estrogen (E2). E2 binds to the traditional E2 receptors (ERs), estrogen receptor alpha (ERα), and estrogen receptor beta (ERβ), as well as the more recently identified G-protein-coupled ER (GPR30), and can exert both genomic and non-genomic actions...
October 24, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/29064078/defective-wnt3-expression-by-testicular-sertoli-cells-compromise-male-fertility
#10
Sayon Basu, Satya Pal Arya, Abul Usmani, Bhola Shankar Pradhan, Rajesh Kumar Sarkar, Nirmalya Ganguli, Mansi Shukla, Kamal Mandal, Surendra Singh, Kanchan Sarda, Subeer S Majumdar
Testicular Sertoli cells make a niche for the division and differentiation of germ cells. Sertoli cells respond to increased follicle-stimulating hormone (FSH) and testosterone (T) levels at the onset of puberty by producing paracrine factors which affect germ cells and trigger robust onset of spermatogenesis. Such paracrine support to germ cells is absent during infancy, despite Sertoli cells being exposed to high FSH and T within the infant testis. This situation is similar to certain cases of male idiopathic infertility where post-pubertal Sertoli cells fail to support germ cell division and differentiation in spite of endogenous or exogenous hormonal support...
October 24, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29058169/chronic-exercise-reduces-cetp-and-mesterolone-treatment-counteracts-exercise-benefits-on-plasma-lipoproteins-profile-studies-in-transgenic-mice
#11
Andrea Camargo Casquero, Jairo Augusto Berti, Laura Lauand Sampaio Teixeira, Helena Coutinho Franco de Oliveira
Regular exercise and anabolic androgenic steroids have opposing effects on the plasma lipoprotein profile and risk of cardio-metabolic diseases in humans. Studies in humans and animal models show conflicting results. Here, we used a mice model genetically modified to mimic human lipoprotein profile and metabolism. They under-express the endogenous LDL receptor gene (R1) and express a human transgene encoding the cholesteryl ester transfer protein (CETP), normally absent in mice. The present study was designed to evaluate the independent and interactive effects of testosterone supplementation, exercise training and CETP expression on the plasma lipoprotein profile and CETP activity...
October 20, 2017: Lipids
https://www.readbyqxmd.com/read/29037971/to-fight-or-mate-hormonal-control-of-sex-recognition-male-sexual-behavior-and-aggression-in-the-gecko-lizard
#12
Tereza Schořálková, Lukáš Kratochvíl, Lukáš Kubička
Squamate reptiles are a highly diversified vertebrate group with extensive variability in social behavior and sexual dimorphism. However, hormonal control of these traits has not previously been investigated in sufficient depth in many squamate lineages. Here, we studied the hormonal control of male sexual behavior, aggressiveness, copulatory organ (hemipenis) size and sex recognition in the gecko Paroedura picta, comparing ovariectomized females, ovariectomized females treated with exogenous dihydrotestosterone (DHT), ovariectomized females treated with exogenous testosterone (T), control females and males...
October 23, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29034815/association-of-the-vitamin-d-receptor-foki-gene-polymorphism-with-sex-and-non-sex-associated-cancers-a-meta-analysis
#13
Lukasz Laczmanski, Felicja Lwow, Anna Osina, Martyna Kepska, Izabela Laczmanska, Wojciech Witkiewicz
Currently higher morbidity and mortality rates are observed in cancer diseases, especially sex-dependent cancers. A positive role of endogenous vitamin D concentration in cancer diseases has been reported in many publications. Furthermore, there has been observed a relationship between serum vitamin D and testosterone concentrations in an elderly Caucasian population carrying the vitamin D receptor FokI gene polymorphism. The aim of this study was to investigate whether the vitamin D receptor FokI polymorphism is associated with cancerogenesis in sex-dependent cancers...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28975673/influence-of-dutasteride-treatment-on-serum-hormone-levels-and-aging-male-symptoms-in-patients-with-benign-prostatic-enlargement
#14
Takahiro Maeda, Eiji Kikuchi, Masanori Hasegawa, Keiko Homma, Toshiyuki Ando, Kenjiro Suzuki, Gou Kaneko, Ryuichi Mizuno, Akira Miyajima, Mototsugu Oya
OBJECTIVES: To clarify the effects of dutasteride on serum hormone levels and aging male symptoms in patients with benign prostatic enlargement. METHODS: The present prospective study was carried out in 110 symptomatic benign prostatic enlargement patients treated with daily administration of 0.5 mg dutasteride. We analyzed serum hormonal levels and aging related symptoms using a validated Aging Male Symptom questionnaire at baseline and after 3 months of dutasteride treatment...
October 3, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28974500/sex-differences-in-circulating-progenitor-cells
#15
Matthew L Topel, Salim S Hayek, Yi-An Ko, Pratik B Sandesara, Ayman Samman Tahhan, Iraj Hesaroieh, Ernestine Mahar, Greg S Martin, Edmund K Waller, Arshed A Quyyumi
BACKGROUND: Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. Whether biologic sex and sex hormones influence PC numbers remains a subject of controversy. We sought to determine sex differences in circulating PCs in both healthy persons and patients with coronary artery disease, and to determine their association with sex hormone levels. METHODS AND RESULTS: In 642 participants (mean age 48 years, 69% women, 23% black) free from cardiovascular disease, we measured circulating PC counts as CD45(med+) mononuclear cells coexpressing CD34 and its subsets expressing CD133, chemokine (C-X-C motif) receptor 4, and vascular endothelial growth factor receptor 2 epitopes using flow cytometry...
October 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28965026/impact-of-a-timed-release-fsh-treatment-from-2-to-6-months-of-age-in-bulls-i-endocrine-and-testicular-development-of-beef-bulls
#16
B R Harstine, L H Cruppe, F M Abreu, A D Rodrigues, C Premanandan, J M DeJarnette, M L Day
In prepubertal males, FSH facilitates Sertoli cell proliferation and testis maturation. The study aimed to determine the effect of an exogenous FSH treatment on hormone secretion and testis development in Angus bulls. Bulls (n = 22) weaned at 53 ± 3.8 days of age were randomized into two treatment groups based on age and pedigree. Beginning at Day 59, bulls were injected im every 3.5 days with either 30 mg FSH (Folltropin-V; NIH-FSH-P1 units) in a 2% hyaluronan solution (FSH-HA, n = 11) or saline (control, n = 11) until Day 167...
January 1, 2018: Theriogenology
https://www.readbyqxmd.com/read/28961951/the-polycystic-ovary-syndrome-associated-gene-yap1-is-regulated-by-gonadotropins-and-sex-steroid-hormones-in-hyperandrogenism-induced-oligo-ovulation-in-mouse
#17
Shu-Yan Ji, Xiao-Man Liu, Bo-Tai Li, Yin-Li Zhang, Hong-Bin Liu, Yu-Chao Zhang, Zi-Jiang Chen, Junping Liu, Heng-Yu Fan
STUDY QUESTION: What is the physiological function of Yes-associated protein-1 (Yap1), a susceptibility gene for polycystic ovary syndrome (PCOS), in ovarian granulosa cells (GCs)? SUMMARY ANSWER: Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1; however, the preovulatory inhibition of YAP1 activity in GCs is a prerequisite of LH actions. WHAT IS KNOWN ALREADY: PCOS is a common gynecologic and endocrine disease with multiple short and long-term consequences...
October 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28960904/high-volume-steroid-isotopic-standards-developed-as-working-standards-for-gas-chromatography-combustion-isotope-ratio-mass-spectrometry
#18
Herbert J Tobias, J Thomas Brenna
High precision carbon isotope ratio analysis of urinary steroids by gas chromatography combustion isotope ratio mass spectrometry (GCC-IRMS) is the official test to detect illicit doping of synthetic versions of endogenous steroids such as testosterone. Our group created the first steroid isotopic standards (SIS) specifically for the World Anti-Doping Agency (WADA) accredited laboratories. The standards contain mixtures of steroids as acetates or free steroids at ~400 μg each per ampoule and have been widely distributed to anti-doping laboratories to facilitate comparability of inter-laboratory results...
September 28, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28954502/clinical-and-hormonal-features-of-women-with-polycystic-ovary-syndrome-living-in-rural-and-urban-areas
#19
Krzysztof Katulski, Adam Czyzyk, Natalia Podkowa, Agnieszka Podfigurna-Stopa, Natalia Ignaszak, Katarzyna Paczkowska, Sylwia Slawek, Dariusz Szpurek, Blazej Meczekalski
INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies among women at reproductive age, but its pathology remains unknown. From epidemiological studies it is known that endogenous, mainly genetic and exogenous, environmental factors are of importance. OBJECTIVE: The aim of the study was to compare the phenotype of women diagnosed with PCOS from urban and rural areas of Poland. According to the knowledge of the authors, this is first such study...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28946965/testosterone-deficiency-in-dialysis-patients-difference-between-dialysis-techniques
#20
Secundino Cigarrán, Francisco Coronel, Enrique Florit, Jesús Calviño, Juan Villa, Lourdes Gonzalez Tabares, José Antonio Herrero, Juan Jesús Carrero
Testosterone deficiency is a prevalent condition in male patients with chronic kidney disease. However, it is not known whether the type of renal replacement therapy has an impact on testosterone deficiency that accompanies loss of renal function. METHODS: The cross-sectional study enrolled 79 prevalent male patients on dialysis; 43 on haemodialysis (HD) and 36 on peritoneal dialysis (PD). The median age was 69 years and 31.6% were diabetics. Endogenous testosterone levels were measured by immunoluminescence assay (normal range 3-10...
September 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
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