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Endogenous Testosterone

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https://www.readbyqxmd.com/read/28640164/associations-between-postmenopausal-endogenous-sex-hormones-and-c-reactive-protein-a-clearer-picture-with-regional-adiposity-adjustment
#1
Shannon M Conroy, Heather K Neilson, Rachel O'Reilly, Christy G Woolcott, Frank Z Stanczyk, Kerry S Courneya, Christine M Friedenreich
OBJECTIVE: To better understand the pathogenesis of inflammatory-related diseases after menopause, we studied the adiposity-independent association between endogenous sex hormones and C-reactive protein (CRP), a biomarker of inflammation. METHODS: We conducted a secondary, cross-sectional analysis of baseline data from the Alberta Physical Activity and Breast Cancer Prevention Trial (2003-2007), including 319 healthy, postmenopausal women not using hormone therapy...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28591185/selection-of-suitable-endogenous-reference-genes-for-qpcr-in-kidney-and-hypothalamus-of-rats-under-testosterone-influence
#2
Khadijeh Gholami, Su Yi Loh, Naguib Salleh, Sau Kuen Lam, See Ziau Hoe
Real-time quantitative PCR (qPCR) is the most reliable and accurate technique for analyses of gene expression. Endogenous reference genes are being used to normalize qPCR data even though their expression may vary under different conditions and in different tissues. Nonetheless, verification of expression of reference genes in selected studied tissue is essential in order to accurately assess the level of expression of target genes of interest. Therefore, in this study, we attempted to examine six commonly used reference genes in order to identify the gene being expressed most constantly under the influence of testosterone in the kidneys and hypothalamus...
2017: PloS One
https://www.readbyqxmd.com/read/28589993/photoperiodic-time-measurement-and-photoentrainment-of-a-circadian-locomotor-activity-rhythm-in-subtropical-tree-sparrows
#3
Anand S Dixit, Namram S Singh, Iadalangki Bamon
Experiments were performed on the subtropical tree sparrow (Passer montanus) to investigate the involvement of an endogenous circadian rhythm in photoperiodic time measurement during the initiation of gonadal growth and functions and also to study the photic entrainment of the circadian activity rhythm. Groups of photosensitive birds of both sexes were exposed to different "night-interruption" light-dark regimes of 24 h duration viz., G1 - 6L/5D/1L/12D, G2 - 6L/6D/1L/11D, G3 - 6L/7D/1L/10D, G4 - 6L/8D/1L/9D, G5 - 6L/10D/1L/7D, G6 - 6L/12D/1L/5D, G7 - 6L/14D/1L/3D and G8 - 6L/16D/1L/1D for 30 days in which 17 h long nights were interrupted by 1 h light pulse falling at different ZTs (i...
June 7, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28581652/adolescent-personality-as-risk-and-resiliency-in-the-testosterone-externalizing-association
#4
Kathleen W Reardon, Kathrin Herzhoff, Jennifer L Tackett
Previous investigations of testosterone and externalizing behavior have provided mixed findings. We tested the hypothesis that self-regulatory personality moderates the testosterone-externalizing behavior association in adolescence. Parents reported on their 13- to 18-year-old (N = 106, Mage = 16.01, SD = 1.29) children's personalities and psychopathology. Testosterone was measured via drool samples. As hypothesized, personality moderated the testosterone-externalizing behavior association. High testosterone predicted higher levels of externalizing behaviors, but only for adolescents low in Agreeableness and Conscientiousness...
September 2016: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28576650/steroid-metabolism-in-the-brain-from-bird-watching-to-molecular-biology-a-personal-journey
#5
REVIEW
Jacques Balthazart
Since Arnold Adolph Berthold established in 1849 the critical role of the testes in the activation of male sexual behavior, intensive research has identified many sophisticated neurochemical and molecular mechanisms mediating this action. Studies in Japanese quail demonstrated the critical role of testosterone action and of testosterone aromatization in the sexually dimorphic medial preoptic nucleus in the activation of male copulatory behavior. The development of an immunohistochemical visualization of brain aromatase in quail then allowed further refinement in the localization of the sites of neuroestrogens production...
June 4, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28576648/sex-differences-and-sex-hormones-in-anxiety-like-behavior-of-aging-rats
#6
Emese Domonkos, Veronika Borbélyová, Melinda Csongová, Martin Bosý, Mária Kačmárová, Daniela Ostatníková, Július Hodosy, Peter Celec
Sex differences in the prevalence of affective disorders might be attributable to different sex hormone milieu. The effects of short-term sex hormone deficiency on behavior, especially on anxiety have been studied in numerous animal experiments, mainly on young adult rats and mice. However, sex differences in aged animals and the effects of long-term hypogonadism are understudied. The aim of our study was to analyze sex differences in anxiety-like behavior in aged rats and to prove whether they can be attributed to endogenous sex hormone production in males...
June 8, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28575850/deletion-of-tumor-suppressors-adenomatous-polyposis-coli-and-smad4-in-murine-luminal-epithelial-cells-causes-invasive-prostate-cancer-and-loss-of-androgen-receptor-expression
#7
Kenneth C Valkenburg, Angelo M De Marzo, Bart O Williams
Prostate cancer is the most diagnosed non-skin cancer in the US and kills approximately 27,000 men per year in the US. Additional genetic mouse models are needed that recapitulate the heterogeneous nature of human prostate cancer. The Wnt/beta-catenin signaling pathway is important for human prostate tumorigenesis and metastasis, and also drives tumorigenesis in mouse models. Loss of Smad4 has also been found in human prostate cancer and drives tumorigenesis and metastasis when coupled with other genetic aberrations in mouse models...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28556379/role-of-serum-steroid-hormones-in-women-with-stress-urinary-incontinence-a-case-control-study
#8
Barbara Bodner-Adler, Klaus Bodner, Oliver Kimberger, Ksenia Halpern, Malte Rieken, Heinz Koelbl, Wolfgang Umek
OBJECTIVES: To investigate the potential relationship between endogenous sex steroids and presence of stress urinary incontinence (SUI). PATIENTS AND METHODS: A total of 47 peri- and postmenopausal women with SUI were matched 1:1 with 47 continent women based on age, menopausal status, body mass index (BMI) and parity. Blood samples were drawn from all the women for assessment of oestradiol (E2), follicle-stimulating hormone, luteinizing hormone, testosterone, androstendion (AEON), dehydroepiandrosterone sulphate and sex hormone-binding globulin with an electrochemiluminescence immunoassay...
May 29, 2017: BJU International
https://www.readbyqxmd.com/read/28527791/neural-substrates-of-male-parochial-altruism-are-modulated-by-testosterone-and-behavioral-strategy
#9
Luise Reimers, Christian Büchel, Esther K Diekhof
Parochial altruism refers to ingroup favoritism and outgroup hostility and has recently been linked to testosterone. Here, we investigated the neurobiological mechanism of parochial altruism in male soccer fans playing the ultimatum game (UG) against ingroup and outgroup members (i.e., fans of the favorite or of a rivalling team) using functional magnetic resonance imaging. Our results suggest that individual differences in altruistic tendency influence the tendency for parochialism. While altruistic subjects rejected unfair offers independent of team membership, the more self-oriented 'pro-selfs' displayed a stronger ingroup bias and rejected outgroup offers more often...
May 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28507119/regulation-of-the-sperm-calcium-channel-catsper-by-endogenous-steroids-and-plant-triterpenoids
#10
Nadja Mannowetz, Melissa R Miller, Polina V Lishko
The calcium channel of sperm (CatSper) is essential for sperm hyperactivated motility and fertility. The steroid hormone progesterone activates CatSper of human sperm via binding to the serine hydrolase ABHD2. However, steroid specificity of ABHD2 has not been evaluated. Here, we explored whether steroid hormones to which human spermatozoa are exposed in the male and female genital tract influence CatSper activation via modulation of ABHD2. The results show that testosterone, estrogen, and hydrocortisone did not alter basal CatSper currents, whereas the neurosteroid pregnenolone sulfate exerted similar effects as progesterone, likely binding to the same site...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28499525/consecutive-cyproterone-acetate-and-estradiol-treatment-in-late-pubertal-transgender-female-adolescents
#11
Lloyd J W Tack, Robin Heyse, Margarita Craen, Karlien Dhondt, Heidi Vanden Bossche, Jolien Laridaen, Martine Cools
BACKGROUND: Cyproterone acetate (CA) is an antiandrogenic progestin commonly used in adult transwomen to suppress endogenous androgens, often in combination with estrogens to induce feminization. AIM: To assess the (side) effects and biochemical changes of CA alone and in combination with estrogens in adolescent trans-girls. METHODS: This study was a retrospective analysis of clinical and biochemical data from 27 trans-girls who presented at Tanner stage G4 and were treated with CA monotherapy for at least 6 months (mean = 12 months) and then in combination with incremental doses of estrogens (CA + E; mean = 16 months)...
May 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28495861/testosterone-treatment-and-cardiovascular-and-venous-thromboembolism-risk-what-is-new
#12
G Corona, M Dicuio, G Rastrelli, E Maseroli, F Lotti, A Sforza, M Maggi
In men, testosterone (T) production declines as a function of ageing. Late-onset hypogonadism (LOH) is the most commonly used term to indicate this age-related condition. In LOH, the relative clinical significance and the potential benefit of testosterone treatment (TTh) are still the subject of strong criticisms in the scientific community. The debate is further complicated by the recent position statement of the US Food and Drug Administration (FDA) emphasizing that, in LOH, the benefits and safety of TTh have not been fully established...
May 10, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28464076/impact-of-a-timed-release-follicle-stimulating-hormone-treatment-from-one-to-three-months-of-age-on-endocrine-and-testicular-development-of-prepubertal-bulls
#13
B R Harstine, L H Cruppe, F M Abreu, M D Utt, R S Cipriano, A Lemes, C Premanandan, J M DeJarnette, M L Day
In prepubertal bulls, FSH facilitates testis maturation and a transient proliferation of Sertoli cells. Two experiments examined the effects of exogenous FSH on hormone secretion and testis development in Angus bulls. Exogenous FSH treatment consisted of an intramuscular injection (i.m.) of 30 mg FSH (Folltropin-V) in a 2% hyaluronic acid solution (FSH-HA). In Exp. 1, bulls (50 ± 6.5 d of age) received either FSH-HA ( = 5) or saline (control; = 5) on d 50 and 53.5. Blood samples were collected via jugular venipuncture to assess FSH concentrations every 6 h for 24 h after treatment and every 12 h until 84 h...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28439055/-calcium-and-bone-metabolism-across-women-s-life-stages-bone-metabolism-and-estrogen-androgen-balance-in-women
#14
Toshiyuki Yasui, Miwa Fukuoka
Androgen as well as estrogen has physical, psychological and sexual roles in women. The action of androgen on bone health in women is important. The androgen receptor is expressed in osteoblasts and osteocytes but the mechanism has not been clarified in women. It has been reported that endogenous testosterone level was positively correlated with bone mineral density and higher testosterone level might be associated with decrease in bone fractures. Also, it has been reported that bone mineral density in women who received testosterone with estrogen was higher than that in women who received estrogen alone...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28426945/testosterone-levels-in-healthy-men-correlate-negatively-with-serotonin-4-receptor-binding
#15
Erik Perfalk, Sofi da Cunha-Bang, Klaus K Holst, Sune Keller, Claus Svarer, Gitte M Knudsen, Vibe G Frokjaer
The serotonergic system integrates sex steroid information and plays a central role in mood and stress regulation, cognition, appetite and sleep. This interplay may be critical for likelihood of developing depressive episodes, at least in a subgroup of sensitive individuals. The serotonin 4 receptor (5-HT4R) indexes central serotonergic tonus, which may be related to endogenous sex-steroid levels in the mentally healthy state even though this remains elusive. Here we evaluate if peripheral levels of estradiol and testosterone are associated with 5-HT4R binding as imaged by [(11)C]SB207145 positron emission tomography in a group of 41 healthy men...
March 22, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28425408/testosterone-sex-hormone-binding-globulin-and-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#16
Veeravich Jaruvongvanich, Anawin Sanguankeo, Tanawan Riangwiwat, Sikarin Upala
INTRODUCTION AND AIM: Endogenous sex hormones are associated with the risk of diabetes and metabolic syndrome. Recent studies suggested the role of these hormones in nonalcoholic fatty liver disease (NAFLD). We conducted a systematic review and meta-analysis of observational studies investigating the association between sex hormones and NAFLD. MATERIAL AND METHODS: A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through April 2016...
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28423207/nanospray-liquid-chromatography-tandem-mass-spectrometry-analysis-of-steroids-from-gray-whale-blubber
#17
Mary Hayden, Ruchika Bhawal, John Escobedo, Clinton Harmon, Todd M O'Hara, David Klein, Susan San-Francisco, Masoud Zabet-Moghaddam, Céline A J Godard-Codding
RATIONALE: Analysis of steroids from precious blubber biopsies obtained from marine mammals, especially endangered species, can provide valuable information on their endocrine status. Challenges with currently used ELISA methodology include lack of absolute quantitation and incompatibility with multiple steroids analysis due to limited biopsy mass. Development of a sensitive, accurate analytical method for this purpose is critical. METHODS: A nanospray liquid chromatography/tandem mass spectrometry (nanoLC/MS/MS) method was validated for sensitive, specific and quantitative analysis of three steroid hormones, without derivatization, extracted from 50 mg blubber samples...
July 15, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28406697/how-do-we-love-romantic-love-style-in-men-is-related-to-lower-testosterone-levels
#18
J Babková Durdiaková, P Celec, I Koborová, T Sedláčková, G Minárik, D Ostatníková
Testosterone has been widely investigated in associations with many aspects of social interactions, emotions and behavior. No research has been conducted on its contribution to the variability of love styles in human. The aim of this paper was to uncover the possible relationship between not only the actual plasma testosterone levels, but also the prenatal testosterone level (expressed as 2D:4D ratio) and the sensitivity of androgen receptor and love typology in young heathy men. There are six love styles which are primary including Eros (passionate romantic love), Ludus (playful) and Storge (friendly) and secondary love consisting of Mania (obsessive), Pragma (practical realistic) and Agape (altruistic)...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28404691/exemestane-and-its-active-metabolite-17-hydroexemestane-induce-udp-glucuronosyltransferase-ugt-2b17-expression-in-breast-cancer-cells
#19
Apichaya Chanawong, Peter I Mackenzie, Ross A McKinnon, Dong Gui Hu, Robyn Meech
Exemestane (EXE) is an aromatase inhibitor indicated for endocrine therapy of breast cancer in postmenopausal women. The primary active metabolite of EXE, 17-hydroexemestane (17-HE), is inactivated via glucuronidation, mainly by UDP-glucuronosyltransferase 2B17 (UGT2B17). UGT2B17 also has a primary role in inactivation of endogenous androgens testosterone and dihydrotestosterone and may play an important role in regulation of breast and prostate tumor intracrinology. We recently reported that UGT2B17 could be induced by both estrogenic and androgenic ligands in breast cancer cells via binding of the estrogen receptor α (ERα) or the androgen receptor (AR) to a complex regulatory unit in the proximal UGT2B17 promoter...
June 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28386370/modifications-of-anxiety-like-behavior-in-prenatally-stressed-male-offspring-with-imbalance-of-androgens
#20
Julia Fedotova, Viktoria Akulova, Svetlana Pivina, Jozef Dragasek, Martin Caprnda, Peter Kruzliak
Gonadal hormones have been well-known to affect brain regions known to be involved in the modulation of mood and affective-related behavior. Prenatal stress might alter hypothalamic-pituitary-gonadal axis, it could be a target for development of affective-related disorders in male offspring. The present study was designed to examine an anxiety-like behavior in the adult male offspring with low levels of endogenous androgens delivered from pregnant dams exposed to prenatal stress from gestation day 15 to gestation day 19...
2017: American Journal of Translational Research
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