J Delaleu, C Lepelletier, A Calugareanu, A De Masson, E Charvet, A Petit, I Giurgea, S Amselem, S Karabina, M Jachiet, T Mahevas, C Ram-Wolff, M-D Vignon-Pennamen, M Bagot, M Battistella, J-D Bouaziz
Neutrophilic dermatoses (ND) are a group of inflammatory skin conditions characterized by a neutrophilic infiltrate on histopathology with no evidence of infection. ND are classified based upon the localization of neutrophils within the skin and clinical features. Recent findings suggest that ND are due to two main mechanisms: i) a polyclonal hereditary activation of the innate immune system (polygenic or monogenic); or ii) a clonal somatic activation of myeloid cells such as encountered in myelodysplastic syndrome or VEXAS syndrome...
July 20, 2022: La Revue de Médecine Interne