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https://www.readbyqxmd.com/read/29040977/gene-microarray-integrated-with-high-throughput-proteomics-for-the-discovery-of-transthyretin-in-rhabdomyolysis-induced-acute-kidney-injury
#1
Ou Li, Xiaodong Geng, Qian Ma, Weiwei Wang, Ran Liu, Zhong Yin, Siyang Wang, Guangyan Cai, Xiangmei Chen, Quan Hong
BACKGROUND/AIMS: Rhabdomyolysis, one of the leading causes of acute kidney injury (AKI), develops after trauma, drug toxicity, infections, burns, and physical exertion. The aim of this study was to investigate differences in gene and protein expression to elucidate the pathogenesis of rhabdomyolysis (RM)-induced AKI. METHODS: In this study, we used glycerol induced renal injury as a model of RM-induced AKI. Affymetrix U133 plus 2.0 microarrays were used to perform gene microarray analysis...
October 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29040943/liquid-chromatography-tandem-mass-spectrometry-direct-injection-analysis-of-organophosphorus-flame-retardants-in-ontario-surface-water-and-wastewater-effluent
#2
Chunyan Hao, Paul A Helm, David Morse, Eric J Reiner
Organophosphorus flame retardants (OPFRs) started to be used in plastics, electronics and furnishings back in the 1960s and became popular again last decade. They are now widely present in the environment and regarded as "new" emerging organic pollutants. An effective liquid chromatography-tandem mass spectrometry (LC-MS/MS) direct injection analysis (DIA) method was developed to monitor OPFR levels in aquatic environment. The removal of sample extraction and concentration steps not only improved operation efficiency, but also reduced the potential contamination commonly observed during the sample preparation process before...
October 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29040937/a-sensitive-hplc-ms-method-for-simultaneous-determination-of-thirteen-components-in-rat-plasma-and-its-application-to-pharmacokinetic-study-of-tanreqing-injection
#3
Su-Xiang Feng, Xian-He Li, Meng-Meng Wang, Rui Hao, Meng-Meng Li, Lei Zhang, Zhe Wang
A rapid, sensitive and selective method based on high-performance liquid chromatography coupled with Q-Exactive mass spectrometry was developed and validated for simultaneous quantification of thirteen components in rat plasma, including chlorogenic acid, 5-caffeoylquinic acid, 4-caffeoylquinic acid, luteoloside, isochlorogenic acid A, B and C, scutellarin, baicalin, wogonin, baicalein, phillyrin and forsythoside A. After precipitating proteins from the plasma samples with methanol, chromatographic separation of the thirteen components was achieved by using an XBridge™ C18 column (2...
October 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29040936/chemical-profiling-and-quantification-of-dan-deng-tong-nao-capsule-using-ultra-high-performance-liquid-chromatography-coupled-with-high-resolution-hybrid-quadruple-orbitrap-mass-spectrometry
#4
Xiao-Jing Lv, Zhi Sun, Pei-Le Wang, Jing Yang, Tan-Ye Xu, Qing-Quan Jia, Da-Wei Li, Fang-Yi Su, Zhen-Feng Zhu, Jian Kang, Xiao-Jian Zhang
Dan-Deng-Tong-Nao capsule (DDTN) was a traditional Chinese medicine (TCM) formula, and has been widely used for the treatment of stroke clinically which caused by blood stasis. However, the bioactive substances and mechanism are unclear because of the complex compositions in DDTN. In this research, An ultra high-performance liquid chromatography (UHPLC) coupled with hybrid quadruple-orbitrap mass spectrometry (Q-Orbitrap MS) method was utilized to identify the chemical constituents of DDTN. In total, 102 compounds including diterpenes, lactones, flavonoids, and phenolic acids were identified by the accurate masses and fragmentation pathways, and 18 of them were unambiguously determined by comparison of reference standards...
October 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29040932/fabrication-of-porous-covalent-organic-frameworks-as-selective-and-advanced-adsorbents-for-the-on-line-preconcentration-of-trace-elements-against-the-complex-sample-matrix
#5
Jing-Min Liu, Xing-Zhi Wang, Chao-Yue Zhao, Jia-Li Hao, Guo-Zhen Fang, Shuo Wang
Herein, for the first time, the typical porous Covalent Organic Frameworks (COFs) CTpBD with superior chemical stability and large surface area were applied as sorbents for solid phase extraction of trace ions via flow injection followed by inductively coupled plasma mass spectrometry (ICP-MS) detection. The well-prepared and fully-characterized CTpBD COFs were filled in solid phase extraction cartridge as novel and robust adsorbents for element analysis. Separation and enrichment of Cr (III), Mn (II), Co (II), Ni (II), Cd (II), V (V), Cu (II), As (III), Se (IV), and Mo (VI) was then carried out, and the contents were measured by ICP-MS...
October 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29040839/effects-of-the-dietary-carbohydrate-fat-ratio-on-plasma-phosphatidylcholine-profiles-in-human-and-mouse
#6
Mizuki Inoue, Nanami Senoo, Tomoki Sato, Yuri Nishimura, Takumi Nakagawa, Noriyuki Miyoshi, Toshinao Goda, Akihito Morita, Shinji Miura
Phosphatidylcholines (PCs), a major class of human plasma phospholipids, are composed of highly diverse fatty acids. Because the dietary carbohydrate-fat ratio alters the hepatic fatty acid metabolism, plasma fatty acids that bind PCs, which are secreted as lipoproteins from the liver, may be affected by long-term consumption of a high-carbohydrate diet or a high-fat diet. Therefore, in this study, we profiled the plasma PC species comprehensively in formulated dieting conditions to identify those phospholipid molecules that reflect the dietary carbohydrate-fat ratio...
September 15, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29040821/dietary-intake-and-omega-3-dha-status-in-pregnant-women-who-are-overweight
#7
Adriana V Gaitán, Merritt L Drewery, Carly A Thaxton, Kennet M Carabante, Ericka Seidemann, Karen Elkind-Hirsch, Carol J Lammi-Keefe
OBJECTIVE: To estimate dietary intake of pregnant women who are overweight, assess their omega-3 docosahexaenoic acid (DHA) status, and compare results between Black and White women. DESIGN: Cross-sectional study with a longitudinal component (dietary assessment). SETTING: Outpatient clinics at Woman's Hospital, Baton Rouge, Louisiana and telephone calls. PARTICIPANTS: Pregnant women (N = 21) who were overweight (body mass index = 25...
October 14, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29040801/molecular-level-insight-into-the-interaction-of-phospholipid-bilayers-with-cellulose
#8
Andrei Yu Kostritskii, Dmitry Alekseevich Tolmachev, Natalia Viacheslavovna Lukasheva, Andrey A Gurtovenko
A molecular-level insight into the interactions of phospholipid molecules with cellulose is crucial for the development of novel cellulose-based materials for wound dressing. Here we employ the state-of-the-art computer simulations to unlock for a first time the molecular mechanisms behind such interactions. To this end, we performed a series of atomic-scale molecular dynamics simulations of phospholipid bilayers on a crystalline cellulose support at various hydration levels of the bilayer leaflets next to the cellulose surface...
October 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29040688/the-online-tabloid-proteome-an-annotated-database-of-protein-associations
#9
Surya Gupta, Demet Turan, Jan Tavernier, Lennart Martens
A complete knowledge of the proteome can only be attained by determining the associations between proteins, along with the nature of these associations (e.g. physical contact in protein-protein interactions, participation in complex formation or different roles in the same pathway). Despite extensive efforts in elucidating direct protein interactions, our knowledge on the complete spectrum of protein associations remains limited. We therefore developed a new approach that detects protein associations from identifications obtained after re-processing of large-scale, public mass spectrometry-based proteomics data...
October 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040685/a-pooled-analysis-of-dietary-sugar-carbohydrate-intake-and-esophageal-and-gastric-cardia-adenocarcinoma-incidence-and-survival-in-the-usa
#10
Nan Li, Jessica L Petrick, Susan E Steck, Patrick T Bradshaw, Kathleen M McClain, Nicole M Niehoff, Lawrence S Engel, Nicholas J Shaheen, Harvey A Risch, Thomas L Vaughan, Anna H Wu, Marilie D Gammon
Background: During the past 40 years, esophageal/gastric cardia adenocarcinoma (EA/GCA) incidence increased in Westernized countries, but survival remained low. A parallel increase in sugar intake, which may facilitate carcinogenesis by promoting hyperglycaemia, led us to examine sugar/carbohydrate intake in association with EA/GCA incidence and survival. Methods: We pooled 500 EA cases, 529 GCA cases and 2027 controls from two US population-based case-control studies with cases followed for vital status...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040631/longevity-fertility-and-fecundity-of-adult-blow-flies-diptera-calliphoridae-held-at-varying-densities-implications-for-use-in-bioconversion-of-waste
#11
Nina Jennifer Parry, Elsje Pieterse, Christopher William Weldon
Large numbers of flies are needed to produce the quantity of larvae required for insect bioconversion of waste. However, this 'mass-rearing' may negatively affect adult survival and reproductive output. This study assessed the suitability for mass-rearing of four blow fly species, Chrysomya chloropyga, Chrysomya chloropyga (Wiedemann), Chrysomya megacephala (F.), Chrysomya putoria (Wiedemann) and Lucilia sericata (Meigen). Flies were kept at densities of 20, 50, 100, 250, 500, and 1,000 flies per 30 × 30 × 30 cm cage with an even sex ratio...
October 11, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29040630/assessment-of-beta-cell-mass-and-function-by-airmax-and-ivgtt-in-high-risk-subjects-for-type-1-diabetes
#12
Wei Hao, Alyssa Wookwyk, Craig Beam, Tee Bahnson, Jerry P Palmer, Carla J Greenbaum
Context: There is little information regarding beta cell mass in individuals at early stages of type 1 diabetes (T1D). Objective: To investigate both AIRmax, as a correlate of beta cell mass, and beta cell function by IVGTT in subjects at early stages of T1D. Design/Setting/Participants: Forty subjects were enrolled: (1) low risk group: relatives of patients with T1D with 0-1 antibody (n=21) and (2) high risk group: relatives with > 2 antibodies (n=19)...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29040623/socio-economic-trajectories-and-cardiovascular-disease-mortality-in-older-people-the-english-longitudinal-study-of-ageing
#13
Silvia Stringhini, Paola Zaninotto, Meena Kumari, Mika Kivimäki, Camille Lassale, G David Batty
Background: Socio-economic status from early life has been linked to cardiovascular disease risk, but the impact of life-course socio-economic trajectories, as well as the mechanisms underlying social inequalities in cardiovascular disease risk, is uncertain. Objectives: We assessed the role of behavioural, psychosocial and physiological (including inflammatory) factors in the association between life-course socio-economic status and cardiovascular disease mortality in older adults...
July 28, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040620/fitness-of-mass-reared-males-of-anastrepha-obliqua-diptera-tephritidae-resulting-from-mating-competition-tests-in-field-cages
#14
Emilio Hernández, Pablo Liedo, Jorge Toledo, Pablo Montoya, Hugo Perales, Lorena Ruiz-Montoya
The sterile insect technique uses males that have been mass-reared in a controlled environment. The insects, once released in the field, must compete to mate. However, the mass-rearing condition supposes a loss of fitness that will be noticeable by wild females. To compare the fitness of wild males and mass-reared males, three competition settings were established. In setting 1, wild males, mass-reared males and wild females were released in field cages. In setting 2, wild females and wild males were released without competition, and in setting 3, mass-reared males and mass-reared females were also released without competition...
October 11, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29040598/effect-of-metformin-on-vascular-function-in-children-with-type-1-diabetes-a-12-month-randomized-controlled-trial
#15
Jemma J A Anderson, Jennifer J Couper, Lynne C Giles, Catherine E Leggett, Roger Gent, Brian Coppin, Alexia S Peña
Context: Children with type 1 diabetes have vascular dysfunction preceding atherosclerosis. Early interventions are needed to reduce cardiovascular disease. Objective: To evaluate the effect of metformin on vascular function in type 1 diabetes children. Design: 12 month double blind, randomized, placebo-controlled trial. Setting: Tertiary pediatric diabetes clinic. Participants: 90 type 1 diabetes children(8-18 years), above 50th percentile body mass index (BMI)...
October 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29040586/plasma-nervonic-acid-is-a-potential-biomarker-for-major-depressive-disorder-a-pilot-study
#16
Yuki Kageyama, Takaoki Kasahara, Takemichi Nakamura, Kotaro Hattori, Yasuhiko Deguchi, Munehide Tani, Kenji Kuroda, Sumiko Yoshida, Yu-Ichi Goto, Koki Inoue, Tadafumi Kato
Background: Diagnostic biomarkers of major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ) are urgently needed because none are currently available. Methods: We performed a comprehensive metabolome analysis of plasma samples from drug-free patients with MDD (n = 9), BD (n = 6), SZ (n = 17), and matched healthy controls (n = 19) (cohort 1), using liquid chromatography time-of-flight mass spectrometry. A significant effect of diagnosis was found for two metabolites: nervonic acid and cortisone, with nervonic acid being the most significantly altered...
October 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29040554/frailty-syndrome-an-emerging-clinical-problem-in-the-everyday-management-of-clinical-arrhythmias-the-results-of-the-european-heart-rhythm-association-survey
#17
Stefano Fumagalli, Tatjana S Potpara, Torben Bjerregaard Larsen, Kristina H Haugaa, Dan Dobreanu, Alessandro Proclemer, Nikolaos Dagres
The age of patients presenting with complex arrhythmias is increasing. Frailty is a multifaceted syndrome characterized by an increased vulnerability to stressors and a decreased ability to maintain homeostasis. The prevalence of frailty is associated with age. The aims of this European Heart Rhythm Association (EHRA) EP Wire survey were to evaluate the proportion of patients with frailty and its influence on the clinical management of arrhythmias. A total of 41 centres-members of the EHRA Electrophysiology Research Network-in 14 European countries completed the web-based questionnaire in June 2017...
October 10, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29040513/targeted-metabolomics-reveals-reduced-levels-of-polyunsaturated-choline-plasmalogens-and-a-smaller-dimethylarginine-arginine-ratio-in-the-follicular-fluid-of-patients-with-a-diminished-ovarian-reserve
#18
J M Chao de la Barca, T Boueilh, G Simard, L Boucret, V Ferré-L'Hotellier, L Tessier, C Gadras, P E Bouet, P Descamps, V Procaccio, P Reynier, P May-Panloup
STUDY QUESTION: Does the metabolomic profile of the follicular fluid (FF) of patients with a diminished ovarian reserve (DOR) differ from that of patients with a normal ovarian reserve (NOR)? SUMMARY ANSWER: The metabolomic signature of the FF reveals a significant decrease in polyunsaturated choline plasmalogens and methyl arginine transferase activity in DOR patients compared to NOR patients. WHAT IS KNOWN ALREADY: The composition of the FF reflects the exchanges between the oocyte and its microenvironment during its acquisition of gametic competence...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040503/the-role-of-early-life-growth-development-the-fto-gene-and-exclusive-breastfeeding-on-child-bmi-trajectories
#19
Yan Yan Wu, Stephen Lye, Laurent Briollais
Background: Recent studies have implicated the FTO gene in child and adult obesity. A longer duration of exclusive breastfeeding (EXBF) has been shown to reduce body mass index (BMI) and the risk of being overweight in the general population and among FTO gene carriers. However, it remains unclear whether the preventive effect of EXBF could be explained by its impact on early life growth development, e.g. ages at adiposity peak (AP) and adiposity rebound (AR) and BMI velocities in the first years of life, which are major determinants of overweight and obesity later in life...
June 20, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040488/tuberculosis-of-the-esophagus
#20
J A Perdomo, Y Naomoto, M Haisa, T Yamatsuji, Y Kamikawa, N Tanaka
We report a case of a patient with esophageal tuberculosis, a very uncommon form of extrapulrhonar tuberculosis. Initially, because of constitutional symptomatology and radiological findings of mediastinal lymph node enlargement, lymphoma was considered. However, the endoscopic findings of ulcerative masses and a sinus tract revealed by esophagram were suspicious of tuberculous origin. Diagnosis was achieved after bacterial examination of smear samples from esophageal ulcers that revealed bacillus tuberculous and histological demonstration of caseating granulomas in cervical lymph nodes...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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